Aliases for FOXB2 Gene
External Ids for FOXB2 Gene
- HGNC: 23315
- Entrez Gene: 442425
- Ensembl: ENSG00000204612
- UniProtKB: Q5VYV0
Previous GeneCards Identifiers for FOXB2 Gene
- GC09P078824
- GC09P079634
- GC09P049465
Summaries for FOXB2 Gene
GeneCards Summary for FOXB2 Gene
FOXB2 (Forkhead Box B2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXB1.
UniProtKB/Swiss-Prot for FOXB2 Gene
-
Transcription factor.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXB2 Gene
Genomics for FOXB2 Gene
GeneHancer (GH) Regulatory Elements for FOXB2 Gene
Promoters and enhancers for FOXB2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH09I077019 | Promoter | 0.7 | EPDnew | 550.8 | -0.1 | -67 | 0.1 | SUZ12 EZH2 | FOXB2 ENSG00000229857 | |
| GH09I077018 | Enhancer | 0.6 | ENCODE | 550.8 | -0.9 | -885 | 0 | USF1 L3MBTL2 SUZ12 USF2 ZBTB8A ZFHX2 GLIS2 GLIS1 CTBP2 ZBTB26 | FOXB2 ENSG00000229857 | |
| GH09I077021 | Enhancer | 0.6 | ENCODE | 550.8 | -0.8 | -775 | 0.1 | L3MBTL2 SUZ12 ZBTB8A CTBP2 PRDM4 ZBTB26 ZBTB17 EZH2 ZBTB20 | FOXB2 ENSG00000229857 | |
| GH09I077020 | Enhancer | 0.5 | ENCODE | 550.8 | -0.5 | -485 | 0.1 | SUZ12 CTBP2 PRDM4 EZH2 | FOXB2 ENSG00000229857 | |
| GH09I077016 | Enhancer | 0.5 | ENCODE | 0.8 | -3.4 | -3415 | 0.2 | E2F1 SUZ12 CTBP2 EZH2 | FOXB2 ENSG00000229857 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around FOXB2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for FOXB2 Gene
Genomic Locations for FOXB2 Gene
- chr9:77,019,655-77,020,953
- (GRCh38/hg38)
- Size:
- 1,299 bases
- Orientation:
- Plus strand
- chr9:79,634,571-79,635,869
- (GRCh37/hg19)
Genomic View for FOXB2 Gene
Genes around FOXB2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q21.2 by Ensembl
- 9q21.2 by Entrez Gene
- 9q21.2 by HGNC
FOXB2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FOXB2 Gene
Proteins for FOXB2 Gene
-
Protein details for FOXB2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5VYV0-FOXB2_HUMAN
- Recommended name:
- Forkhead box protein B2
- Protein Accession:
- Q5VYV0
Protein attributes for FOXB2 Gene
- Size:
- 432 amino acids
- Molecular mass:
- 45581 Da
- Quaternary structure:
- No Data Available
Protein Expression for FOXB2 Gene
Post-translational modifications for FOXB2 Gene
No Post-translational modifications
Other Protein References for FOXB2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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- Novus Biologicals Antibodies for FOXB2
-
Abcam antibodies for FOXB2
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Protein Products
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- Novus Biologicals proteins for FOXB2
- antibodies-online: Search results for 3 available FOXB2 Proteins ranked by validation data
- Compare Top FOXB2 Proteins
-
Quality Products:
- Search GeneTex for Proteins for FOXB2
Assay Products
- antibodies-online: Search results for 1 available FOXB2 Elisa Kits ranked by validation data
- Compare Top FOXB2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for FOXB2 Gene
Domains & Families for FOXB2 Gene
Gene Families for FOXB2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for FOXB2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FOXB2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FOXB2 Gene
Function for FOXB2 Gene
Molecular function for FOXB2 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor.
Phenotypes From GWAS Catalog for FOXB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | IBA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | IEA | -- |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for FOXB2 Gene
- GenomeRNAi human phenotypes for FOXB2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for FOXB2 gene
-
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- Search ViGene Biosciences for FOXB2
CRISPR Products
-
OriGene CRISPR knockouts for FOXB2
- genomics-online: gRNA clones - Search results for available FOXB2 gene related products
- Applied Biological Materials CRISPR for FOXB2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXB2
- GenScript: Design CRISPR guide RNA sequences for FOXB2
miRNA Products
- Search ViGene Biosciences for FOXB2
Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for available FOXB2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for FOXB2 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for FOXB2
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available FOXB2 gene related products
- orf clones - Search results for available FOXB2 gene related products
- Applied Biological Materials Clones for FOXB2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for FOXB2
-
ViGene Biosciences adenoviral particle packaged cDNA for FOXB2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FOXB2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FOXB2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FOXB2 Gene
Localization for FOXB2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FOXB2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FOXB2 Gene
Pathways & Interactions for FOXB2 Gene
No Data Available
Interacting Proteins for FOXB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0009653 | anatomical structure morphogenesis | IBA | -- |
| GO:0030154 | cell differentiation | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for FOXB2 Gene
Transcripts for FOXB2 Gene
mRNA/cDNA for FOXB2 Gene
- (1) REFSEQ mRNAs :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FOXB2
- genomics-online: gRNA clones - Search results for available FOXB2 gene related products
- Applied Biological Materials CRISPR for FOXB2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXB2
- GenScript: Design CRISPR guide RNA sequences for FOXB2
miRNA Products
- Search ViGene Biosciences for FOXB2
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXB2
- Browse OriGene Inhibitory RNA Products For FOXB2
- genomics-online: shRNA clones - Search results for available FOXB2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for FOXB2 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for FOXB2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FOXB2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available FOXB2 gene related products
- orf clones - Search results for available FOXB2 gene related products
- Applied Biological Materials Clones for FOXB2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for FOXB2 Gene
mRNA differential expression in normal tissues according to GTEx for FOXB2 Gene
This gene is overexpressed in Brain - Hypothalamus (x46.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FOXB2 Gene
NURSA nuclear receptor signaling pathways regulating expression of FOXB2 Gene:
FOXB2SOURCE GeneReport for Unigene cluster for FOXB2 Gene:
Hs.553843Primer Products
-
OriGene qPCR primer pairs for FOXB2
- genomics-online: primer clones - Search results for available FOXB2 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXB2 Gene
Orthologs for FOXB2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FOXB2 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FOXB2 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FOXB2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Foxb2 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FOXB2 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FOXB2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FOXB2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FOXB2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | foxb2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC559714 33 |
|
||
| foxb2 34 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | fd96Cb 34 |
|
ManyToMany | |
| fd96Ca 34 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | lin-31 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany |
- Species where no ortholog for FOXB2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FOXB2 Gene
Paralogs for FOXB2 Gene
(3) SIMAP similar genes for FOXB2 Gene using alignment to 1 proteins:
Variants for FOXB2 Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000768752 | -- | 77,018,059(+) | T/C | upstream_transcript_variant | |
| rs1000832934 | -- | 77,019,254(+) | G/C | upstream_transcript_variant | |
| rs1001222334 | -- | 77,017,691(+) | C/G | upstream_transcript_variant | |
| rs1001448810 | -- | 77,018,491(+) | A/C | upstream_transcript_variant | |
| rs1002597769 | -- | 77,020,857(+) | C/G/T | coding_sequence_variant, synonymous_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759697 | CNV | loss | 17122850 |
| nsv1040363 | CNV | gain | 25217958 |
| nsv1075657 | CNV | deletion | 25765185 |
| nsv831628 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
50.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.75;
33.11% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FOXB2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FOXB2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXB2 Gene
Disorders for FOXB2 Gene
Additional Disease Information for FOXB2
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for FOXB2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXB2 Gene
Publications for FOXB2 Gene
- DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
- A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S … Cupples LA (BMC medical genetics 2007) 44 58
Products for FOXB2 Gene
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- Custom Antibody ServicesOriGene Antibodies for FOXB2
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- Invitrogen Antibodies for FOXB2
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- VectorBuilder custom plasmid, inducible vectors for FOXB2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FOXB2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 41 available FOXB2 Antibodies ranked by validation data
- Compare Top FOXB2 Antibodies
- antibodies-online: Search results for 1 available FOXB2 Elisa Kits ranked by validation data
- Compare Top FOXB2 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 3 available FOXB2 Proteins ranked by validation data
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- Quality Products:
- Search GeneTex for Antibodies for FOXB2
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- ViGene Biosciences adenoviral particle packaged cDNA for FOXB2 gene
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Sources for FOXB2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
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- (128) ViGene Biosciences
- (129) HPO
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- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew