Aliases for FOXB2 Gene
External Ids for FOXB2 Gene
- HGNC: 23315
- Entrez Gene: 442425
- Ensembl: ENSG00000204612
- UniProtKB: Q5VYV0
Previous GeneCards Identifiers for FOXB2 Gene
- GC09P078824
- GC09P079634
- GC09P049465
Summaries for FOXB2 Gene
GeneCards Summary for FOXB2 Gene
FOXB2 (Forkhead Box B2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXE3.
UniProtKB/Swiss-Prot for FOXB2 Gene
-
Transcription factor.
No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXB2 Gene
Genomics for FOXB2 Gene
Regulatory Elements for FOXB2 Gene
Enhancers for FOXB2 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around FOXB2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FOXB2 Gene
- Chromosome:
- 9
- Start:
- 77,019,655 bp from pter
- End:
- 77,020,953 bp from pter
- Size:
- 1,299 bases
- Orientation:
- Plus strand
Genomic View for FOXB2 Gene
Genes around FOXB2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q21.2 by Ensembl
- 9q21.2 by Entrez Gene
- 9q21.2 by HGNC
FOXB2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FOXB2 Gene
Proteins for FOXB2 Gene
-
Protein details for FOXB2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5VYV0-FOXB2_HUMAN
- Recommended name:
- Forkhead box protein B2
- Protein Accession:
- Q5VYV0
Protein attributes for FOXB2 Gene
- Size:
- 432 amino acids
- Molecular mass:
- 45581 Da
- Quaternary structure:
- No Data Available
Protein Expression for FOXB2 Gene
Post-translational modifications for FOXB2 Gene
Other Protein References for FOXB2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FOXB2
- Abcam antibodies for FOXB2
- Invitrogen Antibodies for FOXB2
- antibodies-online Antibodies for FOXB2: See all 38
- GeneTex FOXB2 antibody for FOXB2
-
Santa Cruz Biotechnology (SCBT) Antibodies for FOXB2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FOXB2
- Origene Custom Protein Services for FOXB2
- Novus Biologicals proteins for FOXB2
- antibodies-online Proteins for FOXB2: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FOXB2
Assay Products
- antibodies-online Kits for FOXB2: See all 1
No data available for DME Specific Peptides for FOXB2 Gene
Domains & Families for FOXB2 Gene
Gene Families for FOXB2 Gene
- HGNC:
Protein Domains for FOXB2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FOXB2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q5VYV0- Domain:
-
- Contains 1 fork-head DNA-binding domain.
Function for FOXB2 Gene
Molecular function for FOXB2 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | IBA | -- |
Phenotypes for FOXB2 Gene
- GenomeRNAi human phenotypes for FOXB2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FOXB2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FOXB2 gene
- Search ViGene Biosciences for FOXB2
CRISPR Products
-
OriGene CRISPR knockouts for FOXB2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXB2
- GenScript: Design CRISPR guide RNA sequences for FOXB2
miRNA Products
- Search ViGene Biosciences for FOXB2
Inhibitory RNA Products
- Origene RNAi, siRNA, shRNA, and mouse_rna products in human, mouse, rat for FOXB2
- Browse OriGene Inhibitory RNA Products For FOXB2
-
ViGene Biosciences ready-to-package AAV shRNAs for FOXB2 gene
Clone Products
- OriGene clones in human for FOXB2
- OriGene ORF clones in human,mouse,rat for FOXB2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for FOXB2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FOXB2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FOXB2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FOXB2 Gene
Localization for FOXB2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FOXB2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
No data available for Gene Ontology (GO) - Cellular Components for FOXB2 Gene
Pathways & Interactions for FOXB2 Gene
More details on SuperPathways for FOXB2
No Data Available
Interacting Proteins for FOXB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0030154 | cell differentiation | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for FOXB2 Gene
Transcripts for FOXB2 Gene
mRNA/cDNA for FOXB2 Gene
- (1) REFSEQ mRNAs :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FOXB2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXB2
- GenScript: Design CRISPR guide RNA sequences for FOXB2
miRNA Products
- Search ViGene Biosciences for FOXB2
Inhibitory RNA Products
- Origene RNAi, siRNA, shRNA, and mouse_rna products in human, mouse, rat for FOXB2
- Browse OriGene Inhibitory RNA Products For FOXB2
-
ViGene Biosciences ready-to-package AAV shRNAs for FOXB2 gene
Clone Products
- OriGene clones in human for FOXB2
- OriGene ORF clones in human,mouse,rat for FOXB2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
Flow Cytometry Products
Expression for FOXB2 Gene
mRNA differential expression in normal tissues according to GTEx for FOXB2 Gene
This gene is overexpressed in Brain - Hypothalamus (x46.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FOXB2 Gene
SOURCE GeneReport for Unigene cluster for FOXB2 Gene Hs.553843
Primer Products
-
OriGene qPCR primer pairs for FOXB2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FOXB2 Gene
Orthologs for FOXB2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | FOXB2 35 |
|
||
| FOXB2 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | FOXB2 35 |
|
||
| FOXB2 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | FOXB2 35 |
|
||
| FOXB2 36 |
|
OneToOne | |||
| oppossum (Monodelphis domestica) |
Mammalia | FOXB2 36 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Foxb2 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FOXB2 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FOXB2 35 |
|
||
| FOXB2 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | FOXB2 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | foxb2 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC559714 35 |
|
||
| foxb2 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | fd96Ca 36 |
|
ManyToMany | |
| fd96Cb 36 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | lin-31 36 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
ManyToMany | |
| -- 36 |
|
ManyToMany |
- Species with no ortholog for FOXB2:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FOXB2 Gene
Paralogs for FOXB2 Gene
(3) SIMAP similar genes for FOXB2 Gene using alignment to 1 proteins:
Variants for FOXB2 Gene
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs113067836 | -- | 77,021,139(+) | GTCTG(A/C)ATAAA | downstream-variant-500B | |
| rs113100485 | -- | 77,018,752(+) | CTGCC(G/T)TCGCC | upstream-variant-2KB | |
| rs138048942 | -- | 77,019,777(+) | TACAA(G/T)TTCAT | reference, missense | |
| rs138621722 | -- | 77,019,723(+) | ACCGC(C/T)ATGGC | reference, synonymous-codon | |
| rs193270070 | -- | 77,018,476(+) | CCCGG(C/T)GAACA | upstream-variant-2KB |
Residual Variation Intolerance Score:
50.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.75;
33.11% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FOXB2 Gene
Disorders for FOXB2 Gene
Relevant External Links for FOXB2
No disorders were found for FOXB2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXB2 Gene
Publications for FOXB2 Gene
- DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 67
Products for FOXB2 Gene
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- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FOXB2
- Origene Custom Protein Services for FOXB2
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for FOXB2
- Browse OriGene Inhibitory RNA Products For FOXB2
- OriGene qPCR primer pairs for FOXB2
- OriGene CRISPR knockouts for FOXB2
- OriGene clones in human for FOXB2
- OriGene ORF clones in human,mouse,rat for FOXB2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for FOXB2
- GenScript Custom Assay Services for FOXB2
- GenScript Custom overexpressing Cell Line Services for FOXB2
- GenScript: Design CRISPR guide RNA sequences for FOXB2
- Design optimal peptide antigens
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- Gene Mutant Library, Variants up to 10^11
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- GenScript Custom Peptide Services for FOXB2
- Novus Biologicals Antibodies for FOXB2
- Novus Biologicals proteins for FOXB2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Invitrogen Antibodies for FOXB2
- antibodies-online Antibodies for FOXB2: See all 38
- antibodies-online Kits for FOXB2: See all 1
- antibodies-online Proteins for FOXB2: See all 3
- Search antibodies-online for peptides
- GeneTex FOXB2 antibody for FOXB2
- Search GeneTex for Proteins for FOXB2
- ViGene Biosciences adenoviral particle packaged cDNA for FOXB2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FOXB2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FOXB2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FOXB2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FOXB2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FOXB2 gene
- Search ViGene Biosciences for FOXB2
- Search ViGene Biosciences for FOXB2
- Santa Cruz Biotechnology (SCBT) Antibodies for FOXB2
- Search Santa Cruz Biotechnology (SCBT) for FOXB2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FOXB2
Sources for FOXB2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon