FOXB2 Gene

Aliases
for FOXB2 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC09P078824 GC09P049465

Summaries
for FOXB2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for FOXB2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000009.11  NC_018920.2  NT_008470.20  

Browse SwitchGear Promoter luciferase reporter plasmids

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOXB2

FOXB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P079634:  view genomic region     (about GC identifiers)

Proteins
for FOXB2 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for FOXB2: NX_Q5VYV0

Explore proteomics data for FOXB2 at MOPED


See FOXB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

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	antibodies-online proteins for FOXB2 (3 products)
	antibodies-online peptides for FOXB2

FOXB2 Antibody Products:

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FOXB2 Assay Products:

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	antibodies-online kits for FOXB2 (4 products)

Domains /
Families
for FOXB2 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q5VYV0

Find genes that share domains with FOXB2           About GenesLikeMe

Function
for FOXB2 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

genOway: Develop your customized and physiologically relevant rodent model for FOXB2

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		Predesigned siRNA for gene silencing in human, mouse, rat FOXB2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for FOXB2

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXB2

Localization
for FOXB2 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	4

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for FOXB2 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

Drugs & Compounds
for FOXB2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for FOXB2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for FOXB2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FOXB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CCGGTGCCCA

About this image

Neural Tube (Nervous System)    fully expand to see all 2 entries
Metencephalon
Brain (Nervous System)    fully expand to see all 2 entries
Medulla Oblongata

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXB2

Orthologs
for FOXB2 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for FOXB2 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for FOXB2 gene

FOXA2²  FOXD4L1²  FOXC2²  FOXI2²  FOXB1²  FOXE3²  FOXC1²  FOXD4L2²  

FOXD4L3²  FOXA3²  FOXD4L5²  FOXD1²  FOXD3²  FOXD4L4²  FOXA1²  FOXE1²  

FOXL1²  FOXI1²  FOXD4L6²  FOXS1²  FOXD2²  FOXL2²  FOXD4²  

3 SIMAP similar genes for FOXB2 using alignment to 1 protein entry:     FOXB2_HUMAN:

FOXA3    FOXA2    FOXB1

Find genes that share paralogs with FOXB2           About GenesLikeMe

Genomic Variants
for FOXB2 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FOXB2 (see all 81)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1837853501,2		--	79633025(+)	TCACAG/TGCAGT	1	--	us2k1		0	--	--	--	--
rs734683371,2	C,F	--	79633057(+)	TGAATT/CTGGCA	1	--	us2k1		2		WA	120
rs1495084751,2		--	79633066(+)	CATTTC/GGTGAA	1	--	us2k1		0	--	--	--	--
rs625681431,2	C,F	--	79633088(+)	CTTTCC/TTCCCC	1	--	us2k1		1		NA	2
rs734683391,2	C,F	--	79633099(+)	ATGAGT/GTTTTC	1	--	us2k1		2		WA	120
rs793670041,2	C	--	79633213(+)	AAGGAG/TAGAGA	1	--	us2k1		4		CSA WA NA EA	360
rs734683411,2	C,F	--	79633225(+)	GCTCAC/GAGCGA	1	--	us2k1		7		WA CSA NA EA	365
rs1883255401,2		--	79633358(+)	AGCTGA/CGGGAA	1	--	us2k1		0	--	--	--	--
rs1932700701,2		--	79633392(+)	CCCGGC/TGAACA	1	--	us2k1		0	--	--	--	--
rs123392791,2	C,F,H	--	79633464(+)	TGGGTG/TGAGAG	1	--	us2k1		11		NS EA NA WA	1386

HapMap Linkage Disequilibrium report for FOXB2 (79634571 - 79635869 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for FOXB2:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv831628	CNV	Gain	17160897
nsv893483	CNV	Gain	21882294
essv5453	CNV	CNV	17122850
dgv2390e1	CNV	Complex	17122850

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing FOXB2

DNA2.0 Custom Variant and Variant Library Synthesis for FOXB2

Disorders / Diseases
for FOXB2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for FOXB2 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (Nature 2004)
2. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)⁴ Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)

External Searches for FOXB2 gene

Genome Databases showing FOXB2 gene

Other Databases showing FOXB2 gene

Specialized Databases showing FOXB2 gene

Products
for FOXB2 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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