Aliases for FOXB2 Gene
External Ids for FOXB2 Gene
- HGNC: 23315
- Entrez Gene: 442425
- Ensembl: ENSG00000204612
- UniProtKB: Q5VYV0
Previous GeneCards Identifiers for FOXB2 Gene
- GC09P078824
- GC09P079634
- GC09P049465
Summaries for FOXB2 Gene
GeneCards Summary for FOXB2 Gene
FOXB2 (Forkhead Box B2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXB1.
UniProtKB/Swiss-Prot for FOXB2 Gene
-
Transcription factor.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXB2 Gene
Genomics for FOXB2 Gene
GeneHancer (GH) Regulatory Elements for FOXB2 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH09I077019 | Promoter | 0.7 | EPDnew | 550.8 | -0.1 | -67 | 0.1 | SUZ12 EZH2 | FOXB2 ENSG00000229857 | |
GH09I077018 | Enhancer | 0.6 | ENCODE | 550.8 | -0.9 | -885 | 0 | USF1 L3MBTL2 SUZ12 USF2 ZBTB8A ZFHX2 GLIS2 GLIS1 CTBP2 ZBTB26 | FOXB2 ENSG00000229857 | |
GH09I077021 | Enhancer | 0.6 | ENCODE | 550.8 | -0.8 | -775 | 0.1 | L3MBTL2 SUZ12 ZBTB8A CTBP2 PRDM4 ZBTB26 ZBTB17 EZH2 ZBTB20 | FOXB2 ENSG00000229857 | |
GH09I077020 | Enhancer | 0.5 | ENCODE | 550.8 | -0.5 | -485 | 0.1 | SUZ12 CTBP2 PRDM4 EZH2 | FOXB2 ENSG00000229857 | |
GH09I077016 | Enhancer | 0.5 | ENCODE | 0.8 | -3.4 | -3415 | 0.2 | E2F1 SUZ12 CTBP2 EZH2 | FOXB2 ENSG00000229857 |
Regulatory Element Products
Genomic Locations for FOXB2 Gene
- chr9:77,019,655-77,020,953
- (GRCh38/hg38)
- Size:
- 1,299 bases
- Orientation:
- Plus strand
- chr9:79,634,571-79,635,869
- (GRCh37/hg19)
Genomic View for FOXB2 Gene
- Cytogenetic band:
-
- 9q21.2 by Ensembl
- 9q21.2 by Entrez Gene
- 9q21.2 by HGNC


RefSeq DNA sequence for FOXB2 Gene
Proteins for FOXB2 Gene
-
Protein details for FOXB2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5VYV0-FOXB2_HUMAN
- Recommended name:
- Forkhead box protein B2
- Protein Accession:
- Q5VYV0
Protein attributes for FOXB2 Gene
- Size:
- 432 amino acids
- Molecular mass:
- 45581 Da
- Quaternary structure:
- No Data Available
Protein Expression for FOXB2 Gene
Post-translational modifications for FOXB2 Gene
Other Protein References for FOXB2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
Abcam antibodies for FOXB2
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- antibodies-online: Search results for 3 available FOXB2 Proteins ranked by validation data
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Assay Products
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-
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No data available for DME Specific Peptides for FOXB2 Gene
Domains & Families for FOXB2 Gene
Gene Families for FOXB2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for FOXB2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FOXB2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FOXB2 Gene
Function for FOXB2 Gene
Molecular function for FOXB2 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor.
Phenotypes From GWAS Catalog for FOXB2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | IBA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA binding transcription factor activity | IEA | -- |
GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for FOXB2 Gene
- GenomeRNAi human phenotypes for FOXB2:
Animal Model Products
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-
-
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-
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-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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Clone Products
- VectorBuilder custom plasmid, inducible vectors for FOXB2
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available FOXB2 gene related products
- orf clones - Search results for available FOXB2 gene related products
- Applied Biological Materials Clones for FOXB2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for FOXB2
-
ViGene Biosciences adenoviral particle packaged cDNA for FOXB2 gene
-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FOXB2 Gene
Localization for FOXB2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FOXB2 Gene
- Nucleus.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FOXB2 Gene
Pathways & Interactions for FOXB2 Gene
Interacting Proteins for FOXB2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006351 | transcription, DNA-templated | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
GO:0009653 | anatomical structure morphogenesis | IBA | -- |
GO:0030154 | cell differentiation | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for FOXB2 Gene
Transcripts for FOXB2 Gene
mRNA/cDNA for FOXB2 Gene
- (1) REFSEQ mRNAs :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FOXB2
- genomics-online: gRNA clones - Search results for available FOXB2 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXB2
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miRNA Products
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Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for available FOXB2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for FOXB2 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for FOXB2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FOXB2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available FOXB2 gene related products
- orf clones - Search results for available FOXB2 gene related products
- Applied Biological Materials Clones for FOXB2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for FOXB2 Gene
mRNA differential expression in normal tissues according to GTEx for FOXB2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FOXB2 Gene
NURSA nuclear receptor signaling pathways regulating expression of FOXB2 Gene:
FOXB2SOURCE GeneReport for Unigene cluster for FOXB2 Gene:
Hs.553843Primer Products
-
OriGene qPCR primer pairs for FOXB2
- genomics-online: primer clones - Search results for available FOXB2 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXB2 Gene
Orthologs for FOXB2 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | FOXB2 34 33 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | FOXB2 34 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | FOXB2 34 33 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Foxb2 34 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | FOXB2 34 33 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | FOXB2 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | FOXB2 34 33 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | FOXB2 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | foxb2 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | LOC559714 33 |
|
||
foxb2 34 |
|
OneToOne | |||
fruit fly (Drosophila melanogaster) |
Insecta | fd96Cb 34 |
|
ManyToMany | |
fd96Ca 34 |
|
ManyToMany | |||
worm (Caenorhabditis elegans) |
Secernentea | lin-31 34 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
-- 34 |
|
ManyToMany |
- Species where no ortholog for FOXB2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FOXB2 Gene
Paralogs for FOXB2 Gene
(3) SIMAP similar genes for FOXB2 Gene using alignment to 1 proteins:
Variants for FOXB2 Gene
SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000768752 | -- | 77,018,059(+) | T/C | upstream_transcript_variant | |
rs1000832934 | -- | 77,019,254(+) | G/C | upstream_transcript_variant | |
rs1001222334 | -- | 77,017,691(+) | C/G | upstream_transcript_variant | |
rs1001448810 | -- | 77,018,491(+) | A/C | upstream_transcript_variant | |
rs1002597769 | -- | 77,020,857(+) | C/G/T | coding_sequence_variant, synonymous_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759697 | CNV | loss | 17122850 |
nsv1040363 | CNV | gain | 25217958 |
nsv1075657 | CNV | deletion | 25765185 |
nsv831628 | CNV | gain | 17160897 |
Additional Variant Information for FOXB2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FOXB2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXB2 Gene
Disorders for FOXB2 Gene
Additional Disease Information for FOXB2
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for FOXB2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXB2 Gene
Publications for FOXB2 Gene
- DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
- A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S … Cupples LA (BMC medical genetics 2007) 44 58
Products for FOXB2 Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 41 available FOXB2 Antibodies ranked by validation data
- Compare Top FOXB2 Antibodies
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Sources for FOXB2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
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- (84) Vector BioLabs
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- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
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- (114) diseasecard
- (115) NIH Rare Diseases
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- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew