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Aliases for FOXB2 Gene

Aliases for FOXB2 Gene

  • Forkhead Box B2 2 3
  • Forkhead Box Protein B2 3
  • BA159H20.4 3

External Ids for FOXB2 Gene

Previous GeneCards Identifiers for FOXB2 Gene

  • GC09P078824
  • GC09P079634
  • GC09P049465

Summaries for FOXB2 Gene

GeneCards Summary for FOXB2 Gene

FOXB2 (Forkhead Box B2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and double-stranded DNA binding. An important paralog of this gene is FOXE3.

UniProtKB/Swiss-Prot for FOXB2 Gene

  • Transcription factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXB2 Gene

Genomics for FOXB2 Gene

Regulatory Elements for FOXB2 Gene

Genomic Location for FOXB2 Gene

77,019,655 bp from pter
77,020,953 bp from pter
1,299 bases
Plus strand

Genomic View for FOXB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXB2 Gene

Proteins for FOXB2 Gene

  • Protein details for FOXB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Forkhead box protein B2
    Protein Accession:
    Secondary Accessions:

    Protein attributes for FOXB2 Gene

    432 amino acids
    Molecular mass:
    45581 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXB2 Gene

Proteomics data for FOXB2 Gene at MOPED

Post-translational modifications for FOXB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXB2 Gene

Domains for FOXB2 Gene

Gene Families for FOXB2 Gene

  • FOX :Forkhead boxes

Protein Domains for FOXB2 Gene

Suggested Antigen Peptide Sequences for FOXB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q5VYV0
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXB2: view

Function for FOXB2 Gene

Molecular function for FOXB2 Gene

UniProtKB/Swiss-Prot Function: Transcription factor.

Gene Ontology (GO) - Molecular Function for FOXB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXB2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FOXB2 Gene

Localization for FOXB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXB2 Gene

Subcellular locations from

Jensen Localization Image for FOXB2 Gene COMPARTMENTS Subcellular localization image for FOXB2 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for FOXB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with FOXB2: view

Pathways for FOXB2 Gene

SuperPathways for FOXB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0009653 anatomical structure morphogenesis IBA --
genes like me logo Genes that share ontologies with FOXB2: view

No data available for Pathways by source for FOXB2 Gene

Transcripts for FOXB2 Gene

mRNA/cDNA for FOXB2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for FOXB2 Gene

No ASD Table

Relevant External Links for FOXB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FOXB2 Gene

mRNA expression in normal human tissues for FOXB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXB2 Gene

This gene is overexpressed in Brain - Hypothalamus (46.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FOXB2 Gene

SOURCE GeneReport for Unigene cluster for FOXB2 Gene Hs.553843

genes like me logo Genes that share expressions with FOXB2: view

No data available for mRNA Expression by UniProt/SwissProt for FOXB2 Gene

Orthologs for FOXB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FOXB2 35
  • 99.31 (n)
  • 99.07 (a)
FOXB2 36
  • 99 (a)
(Bos Taurus)
Mammalia FOXB2 35
  • 88.05 (n)
  • 94.27 (a)
FOXB2 36
  • 95 (a)
(Canis familiaris)
Mammalia FOXB2 35
  • 94.61 (n)
  • 98.53 (a)
FOXB2 36
  • 88 (a)
(Mus musculus)
Mammalia Foxb2 16
Foxb2 36
  • 91 (a)
(Monodelphis domestica)
Mammalia FOXB2 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia FOXB2 36
  • 99 (a)
(Gallus gallus)
Aves FOXB2 35
  • 80.58 (n)
  • 84.89 (a)
FOXB2 36
  • 76 (a)
(Anolis carolinensis)
Reptilia FOXB2 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia foxb2 35
  • 69.24 (n)
  • 76.14 (a)
(Danio rerio)
Actinopterygii foxb2 36
  • 65 (a)
LOC559714 35
  • 67.53 (n)
  • 71.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta fd96Ca 36
  • 33 (a)
fd96Cb 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea lin-31 36
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
-- 36
  • 46 (a)
Species with no ortholog for FOXB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXB2 Gene

Gene Tree for FOXB2 (if available)
Gene Tree for FOXB2 (if available)

Paralogs for FOXB2 Gene

Selected SIMAP similar genes for FOXB2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXB2: view

Variants for FOXB2 Gene

Sequence variations from dbSNP and Humsavar for FOXB2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs12339279 -- 77,018,548(+) TGGGT(G/T)GAGAG upstream-variant-2KB
rs58636254 -- 77,019,598(+) CGGAG(-/TGCGGAG)AGATT upstream-variant-2KB
rs62568143 -- 77,018,172(+) CTTTC(C/T)TCCCC upstream-variant-2KB
rs72209201 -- 77,019,593(+) AGGAA(-/CGGAGTG)CGGAG upstream-variant-2KB
rs73468337 -- 77,018,141(+) TGAAT(C/T)TGGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FOXB2 Gene

Variant ID Type Subtype PubMed ID
dgv2390e1 CNV Complex 17122850
essv5453 CNV CNV 17122850
nsv831628 CNV Gain 17160897
nsv893483 CNV Gain 21882294

Relevant External Links for FOXB2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXB2 Gene

Disorders for FOXB2 Gene

Relevant External Links for FOXB2

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with FOXB2: view

No data available for UniProtKB/Swiss-Prot for FOXB2 Gene

Publications for FOXB2 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  2. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S. … Cupples L.A. (BMC Med. Genet. 2007) 48

Products for FOXB2 Gene

Sources for FOXB2 Gene

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