Aliases for FOXB2 Gene
External Ids for FOXB2 Gene
- HGNC: 23315
- Entrez Gene: 442425
- Ensembl: ENSG00000204612
- UniProtKB: Q5VYV0
Previous GeneCards Identifiers for FOXB2 Gene
- GC09P078824
- GC09P079634
- GC09P049465
Summaries for FOXB2 Gene
GeneCards Summary for FOXB2 Gene
FOXB2 (Forkhead Box B2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXB1.
UniProtKB/Swiss-Prot for FOXB2 Gene
-
Transcription factor.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXB2 Gene
Genomics for FOXB2 Gene
Regulatory Elements for FOXB2 Gene
Enhancers for FOXB2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH09G077016 | 0.8 | ENCODE | 0.7 | -3.4 | -3416 | 0.2 | SUZ12 BACH1 BMI1 E2F1 ARID3A EED ZNF207 ETV6 RELB IKZF2 | FOXB2 ENSG00000229857 |
| GH09G077018 | 0.7 | ENCODE | 0.7 | -0.9 | -886 | 0.0 | RNF2 L3MBTL2 SUZ12 CBX2 ZBTB8A ZFHX2 GLIS2 GLIS1 CTBP2 ZBTB26 | FOXB2 ENSG00000229857 |
| GH09G077020 | 0.7 | ENCODE | 0.7 | -0.8 | -776 | 0.1 | RNF2 L3MBTL2 SUZ12 CBX2 ZBTB8A CTBP2 ZBTB26 PRDM4 ZBTB20 EZH2 | FOXB2 ENSG00000229857 |
| GH09G077022 | 0.6 | ENCODE | 0.7 | +3.3 | 3305 | 0.2 | CTCF HDAC2 SUZ12 CBX2 TRIM28 EZH2 | FOXB2 ATP5J2P3 |
| GH09G077019 | 0.6 | ENCODE | 0.7 | -0.5 | -486 | 0.1 | RNF2 SUZ12 CBX2 CBX8 CTBP2 PRDM4 EZH2 TRIM28 | FOXB2 ENSG00000229857 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FOXB2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FOXB2 Gene
- Chromosome:
- 9
- Start:
- 77,019,655 bp from pter
- End:
- 77,020,953 bp from pter
- Size:
- 1,299 bases
- Orientation:
- Plus strand
Genomic View for FOXB2 Gene
Genes around FOXB2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q21.2 by Ensembl
- 9q21.2 by Entrez Gene
- 9q21.2 by HGNC
FOXB2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FOXB2 Gene
Proteins for FOXB2 Gene
-
Protein details for FOXB2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5VYV0-FOXB2_HUMAN
- Recommended name:
- Forkhead box protein B2
- Protein Accession:
- Q5VYV0
Protein attributes for FOXB2 Gene
- Size:
- 432 amino acids
- Molecular mass:
- 45581 Da
- Quaternary structure:
- No Data Available
Protein Expression for FOXB2 Gene
Post-translational modifications for FOXB2 Gene
Other Protein References for FOXB2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FOXB2
- Novus Biologicals Antibodies for FOXB2
-
Abcam antibodies for FOXB2
- Invitrogen Antibodies for FOXB2
- antibodies-online Antibodies for FOXB2: See all 38
- GeneTex FOXB2 antibody for FOXB2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FOXB2
- Origene Custom Protein Services for FOXB2
- Novus Biologicals proteins for FOXB2
- antibodies-online Proteins for FOXB2: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FOXB2
Assay Products
- antibodies-online Kits for FOXB2: See all 1
No data available for DME Specific Peptides for FOXB2 Gene
Domains & Families for FOXB2 Gene
Gene Families for FOXB2 Gene
- HGNC:
Protein Domains for FOXB2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FOXB2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FOXB2 Gene
Function for FOXB2 Gene
Molecular function for FOXB2 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | IBA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IEA | -- |
| GO:0043565 | sequence-specific DNA binding | IBA | -- |
Phenotypes for FOXB2 Gene
- GenomeRNAi human phenotypes for FOXB2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for FOXB2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for FOXB2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FOXB2 gene
- Search ViGene Biosciences for FOXB2
CRISPR Products
-
OriGene CRISPR knockouts for FOXB2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXB2
- GenScript: Design CRISPR guide RNA sequences for FOXB2
miRNA Products
- Search ViGene Biosciences for FOXB2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FOXB2
- Browse OriGene Inhibitory RNA Products For FOXB2
-
ViGene Biosciences ready-to-package AAV shRNAs for FOXB2 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for FOXB2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FOXB2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for FOXB2
-
ViGene Biosciences adenoviral particle packaged cDNA for FOXB2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FOXB2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FOXB2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FOXB2 Gene
Localization for FOXB2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FOXB2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IBA | -- |
Pathways & Interactions for FOXB2 Gene
No Data Available
Interacting Proteins for FOXB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for FOXB2 Gene
Transcripts for FOXB2 Gene
mRNA/cDNA for FOXB2 Gene
- (1) REFSEQ mRNAs :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FOXB2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXB2
- GenScript: Design CRISPR guide RNA sequences for FOXB2
miRNA Products
- Search ViGene Biosciences for FOXB2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FOXB2
- Browse OriGene Inhibitory RNA Products For FOXB2
-
ViGene Biosciences ready-to-package AAV shRNAs for FOXB2 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for FOXB2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FOXB2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for FOXB2 Gene
mRNA differential expression in normal tissues according to GTEx for FOXB2 Gene
This gene is overexpressed in Brain - Hypothalamus (x46.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FOXB2 Gene
NURSA nuclear receptor signaling pathways regulating expression of FOXB2 Gene:
FOXB2SOURCE GeneReport for Unigene cluster for FOXB2 Gene:
Hs.553843Primer Products
-
OriGene qPCR primer pairs for FOXB2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXB2 Gene
Orthologs for FOXB2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FOXB2 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FOXB2 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FOXB2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Foxb2 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FOXB2 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FOXB2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FOXB2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FOXB2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | foxb2 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC559714 34 |
|
||
| foxb2 35 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | fd96Cb 35 |
|
ManyToMany | |
| fd96Ca 35 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | lin-31 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany |
- Species where no ortholog for FOXB2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FOXB2 Gene
Paralogs for FOXB2 Gene
(3) SIMAP similar genes for FOXB2 Gene using alignment to 1 proteins:
Variants for FOXB2 Gene
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000768752 | -- | 77,018,059(+) | CGCGA(C/T)GGTGG | upstream-variant-2KB | |
| rs1000832934 | -- | 77,019,254(+) | ACCTA(C/G)AAAAA | upstream-variant-2KB | |
| rs1001222334 | -- | 77,017,691(+) | AGGAA(C/G)CTCCA | upstream-variant-2KB | |
| rs1001448810 | -- | 77,018,491(+) | GCGCC(A/C)CCCGC | upstream-variant-2KB | |
| rs1002597769 | -- | 77,020,857(+) | GCGGC(C/T)GCGGC | reference, synonymous-codon |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759697 | CNV | loss | 17122850 |
| nsv1040363 | CNV | gain | 25217958 |
| nsv1075657 | CNV | deletion | 25765185 |
| nsv831628 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
50.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.75;
33.11% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FOXB2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FOXB2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXB2 Gene
Disorders for FOXB2 Gene
Relevant External Links for FOXB2
No disorders were found for FOXB2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXB2 Gene
Publications for FOXB2 Gene
- DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
- A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S. … Cupples L.A. (BMC Med. Genet. 2007) 46 64
Products for FOXB2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse Immunoprecipitation Assays
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for FOXB2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FOXB2
- Origene Custom Protein Services for FOXB2
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FOXB2
- Browse OriGene Inhibitory RNA Products For FOXB2
- OriGene qPCR primer pairs for FOXB2
- OriGene CRISPR knockouts for FOXB2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FOXB2
- GenScript: Next-day shipping cDNA ORF clone for FOXB2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for FOXB2
- GenScript Custom Assay Services for FOXB2
- GenScript Custom overexpressing Cell Line Services for FOXB2
- GenScript: Design CRISPR guide RNA sequences for FOXB2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Novus Biologicals Antibodies for FOXB2
- Novus Biologicals proteins for FOXB2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for FOXB2
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Invitrogen Antibodies for FOXB2
- antibodies-online Antibodies for FOXB2: See all 38
- antibodies-online Kits for FOXB2: See all 1
- antibodies-online Proteins for FOXB2: See all 3
- Search antibodies-online for peptides
- GeneTex FOXB2 antibody for FOXB2
- Search GeneTex for Proteins for FOXB2
- ViGene Biosciences adenoviral particle packaged cDNA for FOXB2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FOXB2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FOXB2 gene
- Search ViGene Biosciences for FOXB2
- Horizon Cell Lines for FOXB2
- Cyagen custom Knockout/knockin (KOKI) mouse models for FOXB2
- VectorBuilder custom plasmid, inducible vectors for FOXB2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FOXB2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FOXB2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer