Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FOXB2 Gene

Aliases for FOXB2 Gene

  • Forkhead Box B2 2 3 5
  • BA159H20.4 3

External Ids for FOXB2 Gene

Previous GeneCards Identifiers for FOXB2 Gene

  • GC09P078824
  • GC09P079634
  • GC09P049465

Summaries for FOXB2 Gene

GeneCards Summary for FOXB2 Gene

FOXB2 (Forkhead Box B2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXE3.

UniProtKB/Swiss-Prot for FOXB2 Gene

  • Transcription factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXB2 Gene

Genomics for FOXB2 Gene

Regulatory Elements for FOXB2 Gene

Genomic Location for FOXB2 Gene

Chromosome:
9
Start:
77,019,655 bp from pter
End:
77,020,953 bp from pter
Size:
1,299 bases
Orientation:
Plus strand

Genomic View for FOXB2 Gene

Genes around FOXB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXB2 Gene

Proteins for FOXB2 Gene

  • Protein details for FOXB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VYV0-FOXB2_HUMAN
    Recommended name:
    Forkhead box protein B2
    Protein Accession:
    Q5VYV0

    Protein attributes for FOXB2 Gene

    Size:
    432 amino acids
    Molecular mass:
    45581 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXB2 Gene

Proteomics data for FOXB2 Gene at MOPED

Post-translational modifications for FOXB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXB2 Gene

Domains & Families for FOXB2 Gene

Gene Families for FOXB2 Gene

Protein Domains for FOXB2 Gene

Suggested Antigen Peptide Sequences for FOXB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VYV0

UniProtKB/Swiss-Prot:

FOXB2_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXB2: view

Function for FOXB2 Gene

Molecular function for FOXB2 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor.

Gene Ontology (GO) - Molecular Function for FOXB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with FOXB2: view

Phenotypes for FOXB2 Gene

genes like me logo Genes that share phenotypes with FOXB2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FOXB2 Gene

Localization for FOXB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXB2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXB2 Gene COMPARTMENTS Subcellular localization image for FOXB2 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for FOXB2 Gene

Pathways & Interactions for FOXB2 Gene

SuperPathways for FOXB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with FOXB2: view

No data available for Pathways by source and SIGNOR curated interactions for FOXB2 Gene

Drugs & Compounds for FOXB2 Gene

No Compound Related Data Available

Transcripts for FOXB2 Gene

mRNA/cDNA for FOXB2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for FOXB2 Gene

No ASD Table

Relevant External Links for FOXB2 Gene

GeneLoc Exon Structure for
FOXB2
ECgene alternative splicing isoforms for
FOXB2

Expression for FOXB2 Gene

mRNA expression in normal human tissues for FOXB2 Gene

mRNA differential expression in normal tissues according to GTEx for FOXB2 Gene

This gene is overexpressed in Brain - Hypothalamus (x46.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FOXB2 Gene



SOURCE GeneReport for Unigene cluster for FOXB2 Gene Hs.553843

genes like me logo Genes that share expression patterns with FOXB2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FOXB2 Gene

Orthologs for FOXB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOXB2 35
  • 88.05 (n)
  • 94.27 (a)
FOXB2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXB2 35
  • 94.61 (n)
  • 98.53 (a)
FOXB2 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOXB2 35
  • 99.31 (n)
  • 99.07 (a)
FOXB2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOXB2 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxb2 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXB2 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXB2 35
  • 80.58 (n)
  • 84.89 (a)
FOXB2 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXB2 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxb2 35
  • 69.24 (n)
  • 76.14 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC559714 35
  • 67.53 (n)
  • 71.22 (a)
foxb2 36
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta fd96Ca 36
  • 33 (a)
ManyToMany
fd96Cb 36
  • 37 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lin-31 36
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
Species with no ortholog for FOXB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXB2 Gene

ENSEMBL:
Gene Tree for FOXB2 (if available)
TreeFam:
Gene Tree for FOXB2 (if available)

Paralogs for FOXB2 Gene

(3) SIMAP similar genes for FOXB2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXB2: view

Variants for FOXB2 Gene

Sequence variations from dbSNP and Humsavar for FOXB2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs12339279 -- 77,018,548(+) TGGGT(G/T)GAGAG upstream-variant-2KB
rs58636254 -- 77,019,598(+) CGGAG(-/TGCGGAG)AGATT upstream-variant-2KB
rs72209201 -- 77,019,593(+) AGGAA(-/CGGAGTG)CGGAG upstream-variant-2KB
rs62568143 -- 77,018,172(+) CTTTC(C/T)TCCCC upstream-variant-2KB
rs73651434 -- 77,019,915(+) TTCTG(C/G)GCGCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FOXB2 Gene

Variant ID Type Subtype PubMed ID
dgv2390e1 CNV Complex 17122850
essv5453 CNV CNV 17122850
nsv831628 CNV Gain 17160897
nsv893483 CNV Gain 21882294

Variation tolerance for FOXB2 Gene

Residual Variation Intolerance Score: 50.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.75; 33.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXB2 Gene

HapMap Linkage Disequilibrium report
FOXB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXB2 Gene

Disorders for FOXB2 Gene

Relevant External Links for FOXB2

Genetic Association Database (GAD)
FOXB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXB2

No disorders were found for FOXB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXB2 Gene

Publications for FOXB2 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 67

Products for FOXB2 Gene

Sources for FOXB2 Gene

Back to Top

Content