FOXB2 Gene
protein-coding GIFtS: 31
GCID: GC09P079634
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forkhead box B2
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Aliases
for FOXB2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Forkhead Box B21 2 | | BA159H20.41 | | Forkhead Box Protein B22 |
Export aliases for FOXB2 gene to outside databasesPrevious GC identifers: GC09P078824 GC09P049465 |
Summaries
for FOXB2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FOXB2_HUMAN, Q5VYV0Function: Transcription factor (Probable)
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Genomic Views
for FOXB2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FOXB2 gene promoter:
Sox5 HTF FOXL1 Nkx6-1 POU2F1 POU2F1b POU2F1a Chx10 POU2F1c Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for FOXB2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXB2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q21.2 Ensembl cytogenetic band: 9q21.2 HGNC cytogenetic band: 9q21.2FOXB2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P079634: view genomic region
(about GC identifiers)
Start:
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79,634,571 bp from pter |
End:
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79,635,869 bp from pter |
Size:
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1,299 bases |
Orientation:
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plus strand |
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Proteins
for FOXB2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FOXB2_HUMAN, Q5VYV0 (See
protein sequence)Recommended Name: Forkhead box protein B2 Size: 432 amino acids; 45581 Da
Subcellular location: Nucleus (Probable)Explore the universe of human proteins at neXtProt for FOXB2: NX_Q5VYV0
FOXB2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001013757.1
ENSEMBL proteins: ENSP00000365898
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005667 | transcription factor complex |
IBA | -- |
FOXB2 for ontologies About GeneDecksing
FOXB2 Antibody Products:
Assay Products for FOXB2: |
Protein
Domains /
Families
for FOXB2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FOXB2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5VYV0ProtoNet protein and cluster: Q5VYV0 UniProtKB/Swiss-Prot: FOXB2_HUMAN, Q5VYV0Similarity: Contains 1 fork-head DNA-binding domain |
Function
for FOXB2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FOXB2_HUMAN, Q5VYV0Function: Transcription factor (Probable)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXB2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXB2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FOXB2 (NM_001013735) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOXB2 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FOXB2 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003690 | double-stranded DNA binding |
IBA | -- | | GO:0003705 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
IBA | -- | | GO:0008134 | transcription factor binding |
IBA | -- | | GO:0008301 | DNA binding, bending |
IBA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
FOXB2 for ontologies About GeneDecksing
|
Pathways & Interactions
for FOXB2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXB2
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007389 | pattern specification process |
IBA | -- | | GO:0007420 | brain development |
IBA | -- | | GO:0009790 | embryo development |
IBA | -- | | GO:0009888 | tissue development |
IBA | -- | | GO:0051090 | regulation of sequence-specific DNA binding transcription factor activity |
IBA | -- |
FOXB2 for ontologies About GeneDecksing
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Drugs & Compounds
for FOXB2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FOXB2
Search CenterWatch for drugs/clinical trials and news about FOXB2
|
Transcripts
for FOXB2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FOXB2 gene: NM_001013735.1 Unigene Cluster for FOXB2: Forkhead box B2 Hs.553843 Unigene Representative Sequence: NM_0010137351 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000376708(uc004ako.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXB2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXB2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FOXB2 (NM_001013735) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOXB2 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FOXB2 |
GeneLoc Exon Structure
|
Expression
for FOXB2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FOXB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCGGTGCCCA
About this image
See FOXB2 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.553843
SABiosciences Custom PCR Arrays for FOXB2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXB2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FOXB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXB2 |
Orthologs
for FOXB2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FOXB2 gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for FOXB2 (if available)
TreeFam Gene Tree for FOXB2 (if available) |
Paralogs
for FOXB2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FOXB2 gene
- FOXF12 FOXA22 FOXD4L12 FOXF22 FOXC22 FOXB12 FOXI22 FOXE32
- FOXC12 FOXD4L22 FOXQ12 FOXD4L32 FOXA32 FOXD12 FOXD32 FOXD4L52
- FOXD4L42 FOXE12 FOXL12 FOXA12 FOXI12 FOXD4L62 FOXS12 FOXD22
- FOXL22 FOXD42
3 SIMAP similar genes for FOXB2 using alignment to 1 protein entry: FOXB2_HUMAN:FOXA3 FOXA2 FOXB1
FOXB2 for paralogs About GeneDecksing
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Genomic Variants
for FOXB2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FOXB2 (79634571 - 79635869 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FOXB2
1 CNV: 3771 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOXB2 |
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Disorders
/ Diseases
for FOXB2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FOXB2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed article for FOXB2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FOXB2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
|
External Searches for FOXB2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing FOXB2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FOXB2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FOXB2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FOXB2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FOXB2 gene:
Search GeneIP for patents involving FOXB2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FOXB2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FOXB2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOXB2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOXB2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FOXB2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOXB2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOXB2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FOXB2 | | OriGene Custom Protein Services for FOXB2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FOXB2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOXB2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXB2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXB2 |
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| | | | Search Tocris compounds for FOXB2 |
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 | | | FOXB2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for FOXB2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FOXB2 |
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