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Aliases for FOXB1 Gene

Aliases for FOXB1 Gene

  • Forkhead Box B1 2 3
  • Transcription Factor FKH-5 3 4
  • FKH5 3 4
  • Forkhead Box Protein B1 3
  • HFKH-5 3

External Ids for FOXB1 Gene

Summaries for FOXB1 Gene

GeneCards Summary for FOXB1 Gene

FOXB1 (Forkhead Box B1) is a Protein Coding gene. Diseases associated with FOXB1 include wernicke-korsakoff syndrome. GO annotations related to this gene include sequence-specific DNA binding and double-stranded DNA binding. An important paralog of this gene is FOXE3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXB1 Gene

Genomics for FOXB1 Gene

Genomic Location for FOXB1 Gene

Start:
60,004,222 bp from pter
End:
60,061,730 bp from pter
Size:
57,509 bases
Orientation:
Plus strand

Genomic View for FOXB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXB1 Gene

Regulatory Elements for FOXB1 Gene

Proteins for FOXB1 Gene

  • Protein details for FOXB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99853-FOXB1_HUMAN
    Recommended name:
    Forkhead box protein B1
    Protein Accession:
    Q99853
    Secondary Accessions:
    • O60652
    • O75917
    • Q14CL2

    Protein attributes for FOXB1 Gene

    Size:
    325 amino acids
    Molecular mass:
    34978 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXB1 Gene

Proteomics data for FOXB1 Gene at MOPED

Post-translational modifications for FOXB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXB1 Gene

Domains for FOXB1 Gene

Gene Families for FOXB1 Gene

HGNC:
  • FOX :Forkhead boxes

Protein Domains for FOXB1 Gene

UniProtKB/Swiss-Prot:

FOXB1_HUMAN
Domain:
  • Contains 1 fork-head DNA-binding domain.:
    • Q99853
genes like me logo Genes that share domains with FOXB1: view

Function for FOXB1 Gene

Molecular function for FOXB1 Gene

GENATLAS Biochemistry: transcription factor-like 5,with a Drosophila homeo forkhead DNA binding domain homolog

Gene Ontology (GO) - Molecular Function for FOXB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding ISS --
genes like me logo Genes that share ontologies with FOXB1: view
genes like me logo Genes that share phenotypes with FOXB1: view

Animal Models for FOXB1 Gene

MGI Knock Outs for FOXB1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FOXB1 Gene

Localization for FOXB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXB1 Gene COMPARTMENTS Subcellular localization image for FOXB1 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for FOXB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with FOXB1: view

Pathways for FOXB1 Gene

SuperPathways for FOXB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001655 urogenital system development IEA --
GO:0001756 somitogenesis ISS --
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with FOXB1: view

No data available for Pathways by source for FOXB1 Gene

Transcripts for FOXB1 Gene

mRNA/cDNA for FOXB1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXB1 Gene

Forkhead box B1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXB1 Gene

No ASD Table

Relevant External Links for FOXB1 Gene

GeneLoc Exon Structure for
FOXB1
ECgene alternative splicing isoforms for
FOXB1

Expression for FOXB1 Gene

mRNA expression in normal human tissues for FOXB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXB1 Gene

This gene is overexpressed in Brain - Hypothalamus (16.0), Brain - Substantia nigra (14.8), Testis (8.3), and Brain - Spinal cord (cervical c-1) (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FOXB1 Gene

SOURCE GeneReport for Unigene cluster for FOXB1 Gene Hs.734475

genes like me logo Genes that share expressions with FOXB1: view

Orthologs for FOXB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXB1 36
  • 100 (n)
  • 100 (a)
FOXB1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FOXB1 36
  • 92.51 (n)
  • 99.69 (a)
FOXB1 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXB1 36
  • 94.46 (n)
  • 99.69 (a)
FOXB1 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxb1 36
  • 92 (n)
  • 99.69 (a)
Foxb1 16
Foxb1 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOXB1 37
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXB1 36
  • 89.58 (n)
  • 94.37 (a)
FOXB1 37
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia fkh-5 36
tropical clawed frog
(Silurana tropicalis)
Amphibia foxb1 36
  • 76.98 (n)
  • 88.12 (a)
zebrafish
(Danio rerio)
Actinopterygii foxb1.2 36
foxb1a 36
  • 79.69 (n)
  • 88.22 (a)
foxb1a 37
  • 88 (a)
OneToMany
foxb1a 37
  • 88 (a)
OneToMany
foxb1b 37
  • 80 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta fd96Ca 37
  • 34 (a)
ManyToMany
fd96Cb 37
  • 39 (a)
ManyToMany
fd96Cb 38
  • 73 (a)
fd96Ca 38
  • 84 (a)
fd64A 38
  • 60 (a)
worm
(Caenorhabditis elegans)
Secernentea lin-31 37
  • 42 (a)
OneToMany
lin-31 38
  • 77 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.376 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
ManyToMany
-- 37
  • 48 (a)
ManyToMany
Species with no ortholog for FOXB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXB1 Gene

ENSEMBL:
Gene Tree for FOXB1 (if available)
TreeFam:
Gene Tree for FOXB1 (if available)

Paralogs for FOXB1 Gene

Selected SIMAP similar genes for FOXB1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXB1: view

Variants for FOXB1 Gene

Sequence variations from dbSNP and Humsavar for FOXB1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs3943910 -- 60,003,811(+) TAGTG(C/T)TAAGC upstream-variant-2KB
rs7169031 -- 60,003,578(+) ATTTT(A/T)AAAAA upstream-variant-2KB
rs8024930 -- 60,006,376(+) CCCCC(A/C)CACCC downstream-variant-500B
rs8024933 -- 60,006,378(+) CCCAC(A/C)CCCCC downstream-variant-500B
rs8040887 -- 60,006,022(+) GCCCC(A/C)ACCTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FOXB1 Gene

Variant ID Type Subtype PubMed ID
nsv7266 OTHER Inversion 18451855
nsv904280 CNV Gain 21882294
nsv833028 CNV Gain 17160897
nsv1554 CNV Loss 18451855

Relevant External Links for FOXB1 Gene

HapMap Linkage Disequilibrium report
FOXB1

Disorders for FOXB1 Gene

(1) University of Copenhagen DISEASES for FOXB1 Gene

Relevant External Links for FOXB1

Genetic Association Database (GAD)
FOXB1
genes like me logo Genes that share disorders with FOXB1: view

No data available for UniProtKB/Swiss-Prot for FOXB1 Gene

Publications for FOXB1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PMID: 17903292) Hwang S.J. … Fox C.S. (BMC Med. Genet. 2007) 49

Products for FOXB1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate FOXB1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for FOXB1
    • Block miRNA regulation of FOXB1 using miScript Target Protectors

    Sources for FOXB1 Gene

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