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Aliases for FOXB1 Gene

Aliases for FOXB1 Gene

  • Forkhead Box B1 2 3 5
  • Transcription Factor FKH-5 3 4
  • FKH5 3 4
  • Forkhead Box Protein B1 3
  • HFKH-5 3

External Ids for FOXB1 Gene

Previous GeneCards Identifiers for FOXB1 Gene

  • GC15P055855
  • GC15P053345
  • GC15P057876
  • GC15P058013
  • GC15P058084
  • GC15P060296
  • GC15P037118

Summaries for FOXB1 Gene

GeneCards Summary for FOXB1 Gene

FOXB1 (Forkhead Box B1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXB2.

Additional gene information for FOXB1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXB1 Gene

Genomics for FOXB1 Gene

Regulatory Elements for FOXB1 Gene

Enhancers for FOXB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H059976 0.8 Ensembl ENCODE 12.2 -27.5 -27538 0.6 POLR2A MAX CEBPG MYC GABPA FOXB1 NMNAT1P5
GH15H059918 0.8 ENCODE 12.2 -84.5 -84523 1.5 PKNOX1 EBF1 BATF ZNF324 HIC1 EED PATZ1 FOS ATF7 PRDM10 FOXB1 GC15P059937 DDX18P2
GH15H059886 0.9 ENCODE 10.3 -118.1 -118126 0.2 PKNOX1 INSM2 ZNF76 KLF17 FEZF1 ZNF2 ZSCAN5C KLF7 ZNF391 OVOL3 FOXB1 DDX18P2 GC15P059937
GH15H059917 0.7 ENCODE 12.2 -86.5 -86506 0.2 CTCF MAX ZNF2 RAD21 ZFHX2 GLIS2 PATZ1 SMC3 ZNF143 KLF7 FOXB1 GC15P059937 DDX18P2
GH15H060026 0.5 ENCODE 11.8 +22.5 22495 0.2 ZFHX2 PRDM6 GFI1B FOXB1 LOC105370838
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FOXB1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for FOXB1 Gene

Genomic Locations for FOXB1 Gene
57,509 bases
Plus strand

Genomic View for FOXB1 Gene

Genes around FOXB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXB1 Gene

Proteins for FOXB1 Gene

  • Protein details for FOXB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Forkhead box protein B1
    Protein Accession:
    Secondary Accessions:
    • O60652
    • O75917
    • Q14CL2

    Protein attributes for FOXB1 Gene

    325 amino acids
    Molecular mass:
    34978 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXB1 Gene

Post-translational modifications for FOXB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXB1 Gene

Domains & Families for FOXB1 Gene

Gene Families for FOXB1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOXB1 Gene

Suggested Antigen Peptide Sequences for FOXB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FOXB1: view

No data available for UniProtKB/Swiss-Prot for FOXB1 Gene

Function for FOXB1 Gene

Molecular function for FOXB1 Gene

GENATLAS Biochemistry:
transcription factor-like 5,with a Drosophila homeo forkhead DNA binding domain homolog

Phenotypes From GWAS Catalog for FOXB1 Gene

Gene Ontology (GO) - Molecular Function for FOXB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding ISS --
genes like me logo Genes that share ontologies with FOXB1: view
genes like me logo Genes that share phenotypes with FOXB1: view

Animal Models for FOXB1 Gene

MGI Knock Outs for FOXB1:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXB1 Gene

Localization for FOXB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXB1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXB1 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FOXB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IBA --
genes like me logo Genes that share ontologies with FOXB1: view

Pathways & Interactions for FOXB1 Gene

SuperPathways for FOXB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001655 urogenital system development IEA --
GO:0001756 somitogenesis IEA,ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with FOXB1: view

No data available for Pathways by source and SIGNOR curated interactions for FOXB1 Gene

Drugs & Compounds for FOXB1 Gene

No Compound Related Data Available

Transcripts for FOXB1 Gene

mRNA/cDNA for FOXB1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXB1 Gene

Forkhead box B1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXB1 Gene

No ASD Table

Relevant External Links for FOXB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FOXB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOXB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXB1 Gene

This gene is overexpressed in Brain - Hypothalamus (x16.0), Brain - Substantia nigra (x14.8), Testis (x8.3), and Brain - Spinal cord (cervical c-1) (x7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FOXB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FOXB1 Gene:


SOURCE GeneReport for Unigene cluster for FOXB1 Gene:


Evidence on tissue expression from TISSUES for FOXB1 Gene

  • Lung(4.4)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with FOXB1: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXB1 Gene

Orthologs for FOXB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FOXB1 34 33
  • 100 (n)
(Monodelphis domestica)
Mammalia FOXB1 34
  • 99 (a)
(Canis familiaris)
Mammalia FOXB1 33 34
  • 94.46 (n)
(Bos Taurus)
Mammalia FOXB1 33 34
  • 92.51 (n)
(Mus musculus)
Mammalia Foxb1 34 16 33
  • 92 (n)
(Gallus gallus)
Aves FOXB1 34 33
  • 89.58 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia foxb1 33
  • 76.98 (n)
African clawed frog
(Xenopus laevis)
Amphibia fkh-5 33
(Danio rerio)
Actinopterygii foxb1a 34 34
  • 88 (a)
foxb1b 34
  • 80 (a)
LOC100535158 33
  • 79.69 (n)
foxb1.2 33
fruit fly
(Drosophila melanogaster)
Insecta fd96Ca 35 34
  • 84 (a)
fd96Cb 35 34
  • 73 (a)
fd64A 35
  • 60 (a)
(Caenorhabditis elegans)
Secernentea lin-31 35 34
  • 77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
-- 34
  • 30 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.376 33
Species where no ortholog for FOXB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXB1 Gene

Gene Tree for FOXB1 (if available)
Gene Tree for FOXB1 (if available)

Paralogs for FOXB1 Gene

(11) SIMAP similar genes for FOXB1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXB1: view

Variants for FOXB1 Gene

Sequence variations from dbSNP and Humsavar for FOXB1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000437452 -- 60,004,590(+) GAAGC(G/T)GCGCG utr-variant-5-prime
rs1000888710 -- 60,006,155(+) TGTCC(C/T)CGCCC downstream-variant-500B
rs1001502824 -- 60,003,940(+) TCCGC(G/T)CGGCT upstream-variant-2KB
rs1002710625 -- 60,006,429(+) TCTTT(A/G)CGTCT downstream-variant-500B
rs1002856261 -- 60,003,313(+) GGTGG(A/G)AGGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FOXB1 Gene

Variant ID Type Subtype PubMed ID
nsv951968 CNV deletion 24416366
nsv833028 CNV gain 17160897
nsv7266 OTHER inversion 18451855
nsv1554 CNV deletion 18451855

Variation tolerance for FOXB1 Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXB1 Gene

Disorders for FOXB1 Gene

Relevant External Links for FOXB1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FOXB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXB1 Gene

Publications for FOXB1 Gene

  1. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X … Chen J (Molecular systems biology 2015) 3 60
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 60
  4. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PMID: 17903292) Hwang SJ … Fox CS (BMC medical genetics 2007) 45 60
  5. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S … Cupples LA (BMC medical genetics 2007) 45 60

Products for FOXB1 Gene

Sources for FOXB1 Gene

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