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Aliases for FOXB1 Gene

Aliases for FOXB1 Gene

  • Forkhead Box B1 2 3 5
  • Transcription Factor FKH-5 3 4
  • FKH5 3 4
  • HFKH-5 3

External Ids for FOXB1 Gene

Previous GeneCards Identifiers for FOXB1 Gene

  • GC15P055855
  • GC15P053345
  • GC15P057876
  • GC15P058013
  • GC15P058084
  • GC15P060296
  • GC15P037118

Summaries for FOXB1 Gene

GeneCards Summary for FOXB1 Gene

FOXB1 (Forkhead Box B1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXE3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXB1 Gene

Genomics for FOXB1 Gene

Regulatory Elements for FOXB1 Gene

Enhancers for FOXB1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FOXB1 on UCSC Golden Path with GeneCards custom track

Promoters for FOXB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FOXB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOXB1 Gene

60,004,222 bp from pter
60,061,730 bp from pter
57,509 bases
Plus strand

Genomic View for FOXB1 Gene

Genes around FOXB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXB1 Gene

Proteins for FOXB1 Gene

  • Protein details for FOXB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Forkhead box protein B1
    Protein Accession:
    Secondary Accessions:
    • O60652
    • O75917
    • Q14CL2

    Protein attributes for FOXB1 Gene

    325 amino acids
    Molecular mass:
    34978 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXB1 Gene

Proteomics data for FOXB1 Gene at MOPED

Post-translational modifications for FOXB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FOXB1 Gene

Domains & Families for FOXB1 Gene

Gene Families for FOXB1 Gene

Protein Domains for FOXB1 Gene

Suggested Antigen Peptide Sequences for FOXB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 fork-head DNA-binding domain.
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXB1: view

Function for FOXB1 Gene

Molecular function for FOXB1 Gene

GENATLAS Biochemistry:
transcription factor-like 5,with a Drosophila homeo forkhead DNA binding domain homolog

Gene Ontology (GO) - Molecular Function for FOXB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FOXB1: view
genes like me logo Genes that share phenotypes with FOXB1: view

Animal Models for FOXB1 Gene

MGI Knock Outs for FOXB1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXB1 Gene

Localization for FOXB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXB1 Gene

Subcellular locations from

Jensen Localization Image for FOXB1 Gene COMPARTMENTS Subcellular localization image for FOXB1 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for FOXB1 Gene

Pathways & Interactions for FOXB1 Gene

SuperPathways for FOXB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001655 urogenital system development IEA --
GO:0001756 somitogenesis IEA,ISS --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007412 axon target recognition IEA,ISS --
GO:0007595 lactation IEA,ISS --
genes like me logo Genes that share ontologies with FOXB1: view

No data available for Pathways by source and SIGNOR curated interactions for FOXB1 Gene

Drugs & Compounds for FOXB1 Gene

No Compound Related Data Available

Transcripts for FOXB1 Gene

mRNA/cDNA for FOXB1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXB1 Gene

Forkhead box B1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOXB1 Gene

No ASD Table

Relevant External Links for FOXB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FOXB1 Gene

mRNA expression in normal human tissues for FOXB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXB1 Gene

This gene is overexpressed in Brain - Hypothalamus (x16.0), Brain - Substantia nigra (x14.8), Testis (x8.3), and Brain - Spinal cord (cervical c-1) (x7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FOXB1 Gene

SOURCE GeneReport for Unigene cluster for FOXB1 Gene Hs.734475

genes like me logo Genes that share expression patterns with FOXB1: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FOXB1 Gene

Orthologs for FOXB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FOXB1 35
  • 92.51 (n)
  • 99.69 (a)
FOXB1 36
  • 100 (a)
(Canis familiaris)
Mammalia FOXB1 35
  • 94.46 (n)
  • 99.69 (a)
FOXB1 36
  • 100 (a)
(Mus musculus)
Mammalia Foxb1 35
  • 92 (n)
  • 99.69 (a)
Foxb1 16
Foxb1 36
  • 100 (a)
(Pan troglodytes)
Mammalia FOXB1 35
  • 100 (n)
  • 100 (a)
FOXB1 36
  • 100 (a)
(Monodelphis domestica)
Mammalia FOXB1 36
  • 99 (a)
(Gallus gallus)
Aves FOXB1 35
  • 89.58 (n)
  • 94.37 (a)
FOXB1 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia foxb1 35
  • 76.98 (n)
  • 88.12 (a)
African clawed frog
(Xenopus laevis)
Amphibia fkh-5 35
(Danio rerio)
Actinopterygii foxb1.2 35
foxb1a 35
  • 79.69 (n)
  • 88.22 (a)
foxb1a 36
  • 88 (a)
foxb1a 36
  • 88 (a)
foxb1b 36
  • 80 (a)
fruit fly
(Drosophila melanogaster)
Insecta fd64A 37
  • 60 (a)
fd96Ca 37
  • 84 (a)
fd96Cb 37
  • 73 (a)
fd96Ca 36
  • 34 (a)
fd96Cb 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea lin-31 37
  • 77 (a)
lin-31 36
  • 42 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.376 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
-- 36
  • 48 (a)
Species with no ortholog for FOXB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXB1 Gene

Gene Tree for FOXB1 (if available)
Gene Tree for FOXB1 (if available)

Paralogs for FOXB1 Gene

(11) SIMAP similar genes for FOXB1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXB1: view

Variants for FOXB1 Gene

Sequence variations from dbSNP and Humsavar for FOXB1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs7169031 -- 60,003,578(+) ATTTT(A/T)AAAAA upstream-variant-2KB
rs8024930 -- 60,006,376(+) CCCCC(A/C)CACCC downstream-variant-500B
rs8024933 -- 60,006,378(+) CCCAC(A/C)CCCCC downstream-variant-500B
rs61757398 -- 60,005,735(+) TGCCC(A/G)CCATC reference, missense
rs61758961 -- 60,005,791(+) GCGCT(A/G)CCAGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for FOXB1 Gene

Variant ID Type Subtype PubMed ID
nsv7266 OTHER Inversion 18451855
nsv904280 CNV Gain 21882294
nsv833028 CNV Gain 17160897
nsv1554 CNV Loss 18451855

Variation tolerance for FOXB1 Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FOXB1 Gene

Disorders for FOXB1 Gene

Relevant External Links for FOXB1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FOXB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXB1 Gene

Publications for FOXB1 Gene

  1. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FOXB1 Gene

Sources for FOXB1 Gene