FOXB1 Gene
protein-coding GIFtS : 47
GCID: GC15 P060296
forkhead box B1
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Aliasesfor FOXB1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Forkhead Box B1 1 2 FKH51 2 3 HFKH-51 2 Transcription Factor FKH-52 3 Forkhead Box Protein B12
Export aliases for FOXB1 gene to outside databases Previous GC identifers: GC15P055855 GC15P053345 GC15P057876 GC15P058013 GC15P058084 GC15P037118
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Summariesfor FOXB1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor FOXB1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000015.9 NC_018926.1 NT_010194.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FOXB1 gene promoter: E2F-4 E2F-3a E2F-5 E2F-2 Max S8 POU2F1 E2F-1 E2F HFH-1 Other transcription factors Search SABiosciences Chromatin IP Primers for FOXB1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FOXB1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 15q22 Ensembl cytogenetic band: 15q22.2 HGNC cytogenetic band: 15q22 FOXB1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 15 GeneLoc Exon Structure
GeneLoc location for GC15P060296: view genomic region
(about GC identifiers )
Start:
60,296,421 bp from pter
End:
60,353,929 bp from pter
Size:
57,509 bases
Orientation:
plus strand
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Proteinsfor FOXB1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: FOXB1_HUMAN, Q99853 (See
protein sequence )Recommended Name: Forkhead box protein B1 Size : 325 amino acids; 34978 Da
Subcellular location : Nucleus (By similarity)
Secondary accessions : O60652 O75917 Q14CL2Explore the universe of human proteins at neXtProt for FOXB1: NX_Q99853 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q99853 FOXB1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_036314.2 ENSEMBL proteins: ENSP00000379369 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
ISS -- GO:0005667 transcription factor complex
IBA --
FOXB1 for ontologies About GeneDecksing FOXB1 Antibody Products: Assay Products for FOXB1:
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Protein
Domains / Familiesfor FOXB1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
FOXB1 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q99853 ProtoNet protein and cluster: Q99853
UniProtKB/Swiss-Prot: FOXB1_HUMAN, Q99853 Similarity : Contains 1 fork-head DNA-binding domain
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Functionfor FOXB1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: Genatlas biochemistry entry for FOXB1 : transcription factor-like 5,with a Drosophila homeo forkhead DNA binding domain homolog Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FOXB1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FOXB1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FOXB1 (NM_012182 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOXB1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FOXB1
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003690 double-stranded DNA binding
IBA -- GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
IBA -- GO:0008134 transcription factor binding
IBA -- GO:0008301 DNA binding, bending
IBA -- GO:0043565 sequence-specific DNA binding
ISS --
FOXB1 for ontologies About GeneDecksing 2 GenomeRNAi human phenotypes for FOXB1 :Animal Models: Mouse knock-outs for FOXB1: Foxb1 tm1Blh Foxb1 tm1Pgr 9 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Foxb1) :
FOXB1 for phenotypes About GeneDecksing
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Pathways & Interactionsfor FOXB1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXB1 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)3 Interacting proteins for FOXB1 (Q99853 3 ENSP00000379369 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23 ): About this table
FOXB1 for ontologies About GeneDecksing
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Drugs & Compoundsfor FOXB1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for FOXB1 Search CenterWatch for drugs/clinical trials and news about FOXB1
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Transcriptsfor FOXB1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
OriGene ,
QIAGEN ,
shRNA from
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microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
GenScript ,
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Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for FOXB1 gene: NM_012182.2 Unigene Cluster for FOXB1:
Forkhead box B1 Hs.734475 [show with all ESTs ] Unigene Representative Sequence: AK290944 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000396057 (uc002agj.1 ) ENST00000560857 (uc010bgh.1 ) ENST00000558693 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FOXB1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FOXB1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FOXB1 (NM_012182 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOXB1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FOXB1
Additional cDNA sequence: AF071554.1 AK290944.1 AK314075.1 BC113710.1 EF565104.1 U87393.1
2 DOTS entries : DT.91709583 DT.95255594
3 AceView cDNA sequences :
NM_012182 AF071554 U87393 GeneLoc Exon Structure
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Expression for FOXB1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section FOXB1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCGAGTGGCG
About this image FOXB1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See FOXB1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FOXB1 SOURCE GeneReport for Unigene cluster: Hs.734475 SABiosciences Custom PCR Arrays for FOXB1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FOXB1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat FOXB1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FOXB1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FOXB1
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Orthologsfor FOXB1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for FOXB1 gene from 5/17 species (see all 17 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
LOC1008590301
forkhead box protein B1-like
89.58(n) 94.37(a)
 
100859030 XM_003641816.1 XP_003641864.1
African clawed frog (Xenopus laevis)
Amphibia
fkh-52
forkhead-domain-containing protein 5
77.45(n)
 
AF064810.1
zebrafish (Danio rerio)
Actinopterygii
foxb1.22
forkhead box B1.2
79.45(n)
 
30542 AF052246.1
fruit fly (Drosophila melanogaster)
Insecta
fd96Ca3
embryonic morphogenesis transcription factor
84(a) (best of 3)
 
96B20 --
worm (Caenorhabditis elegans)
Secernentea
lin-313
Expression: VPC, L1 larva, L2 larva, L3 larva
77(a)
 
II(3982653-3986466) --
ENSEMBL Gene Tree for FOXB1 (if available)TreeFam Gene Tree for FOXB1 (if available)
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Paralogsfor FOXB1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for FOXB1 gene FOXF1 2 FOXA2 2 FOXD4L1 2 FOXF2 2 FOXC2 2 FOXI2 2 FOXE3 2 FOXC1 2 FOXD4L2 2 FOXQ1 2 FOXD4L3 2 FOXA3 2 FOXD1 2 FOXD3 2 FOXD4L5 2 FOXD4L4 2 FOXE1 2 FOXL1 2 FOXA1 2 FOXB2 2 FOXI1 2 FOXD4L6 2 FOXS1 2 FOXL2 2 FOXD2 2 FOXD4 2 14 SIMAP similar genes for FOXB1 using alignment to 1 protein entry: FOXB1_HUMAN :FOXA3 FOXC1 FOXL1 FOXA2 FOXI2 FOXI3 FOXD1 FOXB2 FOXS1 FOXF1 FOXI1 FOXD4 FOXA1 FOXG1
FOXB1 for paralogs About GeneDecksing
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Genomic Variantsfor FOXB1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 15 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for FOXB1 (60296421 - 60353929 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for FOXB1: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FOXB1
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Disorders
/ Diseasesfor FOXB1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
FOXB1 for disorders About GeneDecksing 2 diseases for FOXB1 : About MalaCards wernicke-korsakoff syndrome neuronitis 1 disease from the University of Copenhagen DISEASES database for FOXB1 :Wernicke-Korsakoff syndrome Export disorders for FOXB1 gene to outside databases
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Publicationsfor FOXB1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for FOXB1 gene integrated from 9 sources : (articles sorted by number of sources associating them with FOXB1) Utopia : connect your pdf to the dynamic world of online information
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000)
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External Searches for FOXB1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FOXB1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FOXB1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing FOXB1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for FOXB1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for FOXB1 gene: Search GeneIP for patents involving FOXB1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FOXB1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for FOXB1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for FOXB1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FOXB1 OriGene Protein Over-expression Lysate for FOXB1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for FOXB1 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FOXB1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FOXB1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for FOXB1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for FOXB1 OriGene Custom Protein Services for FOXB1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FOXB1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FOXB1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FOXB1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat FOXB1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FOXB1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FOXB1
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FOXB1 Proteins, Antibodies, CLIAs, and ELISAs
ThermoFisher Antibodies for FOXB1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FOXB1
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