Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FOXA3 Gene

Aliases for FOXA3 Gene

  • Forkhead Box A3 2 3
  • HNF3G 3 4 6
  • Hepatocyte Nuclear Factor 3, Gamma 2 3
  • Fork Head-Related Protein FKH H3 3 4
  • Forkhead Box Protein A3 3 4
  • Transcription Factor 3G 3 4
  • HNF-3-Gamma 3 4
  • HNF-3G 3 4
  • TCF-3G 3 4
  • TCF3G 3 4
  • Hepatocyte Nuclear Factor 3-Gamma 3
  • FKHH3 3

External Ids for FOXA3 Gene

Previous HGNC Symbols for FOXA3 Gene

  • HNF3G

Previous GeneCards Identifiers for FOXA3 Gene

  • GC19P047011
  • GC19P046758
  • GC19P051043
  • GC19P051059
  • GC19P046368
  • GC19P042796

Summaries for FOXA3 Gene

Entrez Gene Summary for FOXA3 Gene

  • This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXA3 Gene

FOXA3 (Forkhead Box A3) is a Protein Coding gene. Among its related pathways are L1CAM interactions and Regulation of beta-cell development. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is FOXE3.

UniProtKB/Swiss-Prot for FOXA3 Gene

  • Transcription factor that is thought to act as a pioneer factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis.

Gene Wiki entry for FOXA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXA3 Gene

Genomics for FOXA3 Gene

Regulatory Elements for FOXA3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FOXA3 Gene

Start:
45,863,989 bp from pter
End:
45,873,797 bp from pter
Size:
9,809 bases
Orientation:
Plus strand

Genomic View for FOXA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXA3 Gene

Proteins for FOXA3 Gene

  • Protein details for FOXA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55318-FOXA3_HUMAN
    Recommended name:
    Hepatocyte nuclear factor 3-gamma
    Protein Accession:
    P55318
    Secondary Accessions:
    • A9LYI5
    • Q53F16
    • Q9UMW9

    Protein attributes for FOXA3 Gene

    Size:
    350 amino acids
    Molecular mass:
    37140 Da
    Quaternary structure:
    • Interacts with FOXA2.

    Three dimensional structures from OCA and Proteopedia for FOXA3 Gene

neXtProt entry for FOXA3 Gene

Proteomics data for FOXA3 Gene at MOPED

Post-translational modifications for FOXA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXA3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXA3 Gene

Domains for FOXA3 Gene

Gene Families for FOXA3 Gene

HGNC:
  • FOX :Forkhead boxes

Protein Domains for FOXA3 Gene

Suggested Antigen Peptide Sequences for FOXA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55318

UniProtKB/Swiss-Prot:

FOXA3_HUMAN :
  • P55318
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXA3: view

Function for FOXA3 Gene

Molecular function for FOXA3 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that is thought to act as a pioneer factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis.

Gene Ontology (GO) - Molecular Function for FOXA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 9369482
GO:0008134 transcription factor binding IEA --
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with FOXA3: view

Phenotypes for FOXA3 Gene

genes like me logo Genes that share phenotypes with FOXA3: view

Animal Model Products

miRNA for FOXA3 Gene

miRTarBase miRNAs that target FOXA3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXA3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FOXA3 Gene

Localization for FOXA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXA3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXA3 Gene COMPARTMENTS Subcellular localization image for FOXA3 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for FOXA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FOXA3: view

Pathways for FOXA3 Gene

genes like me logo Genes that share pathways with FOXA3: view

Gene Ontology (GO) - Biological Process for FOXA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001678 cellular glucose homeostasis TAS 9369482
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0006366 transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with FOXA3: view

Transcripts for FOXA3 Gene

mRNA/cDNA for FOXA3 Gene

(41) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXA3 Gene

Forkhead box A3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXA3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXA3 Gene

No ASD Table

Relevant External Links for FOXA3 Gene

GeneLoc Exon Structure for
FOXA3
ECgene alternative splicing isoforms for
FOXA3

Expression for FOXA3 Gene

mRNA expression in normal human tissues for FOXA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXA3 Gene

This gene is overexpressed in Liver (20.2), Pancreas (12.7), Stomach (8.3), and Colon - Transverse (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FOXA3 Gene

SOURCE GeneReport for Unigene cluster for FOXA3 Gene Hs.36137

mRNA Expression by UniProt/SwissProt for FOXA3 Gene

P55318-FOXA3_HUMAN
Tissue specificity: Expressed in erythroleukemia and hepatoma cell lines and in liver and pancreas. Not expressed in any other cell lines or tissues examined.
genes like me logo Genes that share expressions with FOXA3: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Expression partners for FOXA3 Gene

Orthologs for FOXA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOXA3 35
  • 87.11 (n)
  • 90.54 (a)
FOXA3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXA3 35
  • 88.54 (n)
  • 91.4 (a)
FOXA3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxa3 35
  • 81.95 (n)
  • 83.95 (a)
Foxa3 16
Foxa3 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOXA3 35
  • 99.05 (n)
  • 100 (a)
FOXA3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxa3 35
  • 83.09 (n)
  • 85.39 (a)
oppossum
(Monodelphis domestica)
Mammalia FOXA3 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXA3 36
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii foxa3 35
  • 59.81 (n)
  • 55.43 (a)
foxa3 36
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta fkh 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
ManyToMany
CSA.7421 36
  • 23 (a)
ManyToMany
Species with no ortholog for FOXA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXA3 Gene

ENSEMBL:
Gene Tree for FOXA3 (if available)
TreeFam:
Gene Tree for FOXA3 (if available)

Paralogs for FOXA3 Gene

Selected SIMAP similar genes for FOXA3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FOXA3: view

Variants for FOXA3 Gene

Sequence variations from dbSNP and Humsavar for FOXA3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3810327 -- 45,872,959(-) AGTTT(G/T)GGAGG synonymous-codon, reference
rs4803867 -- 45,866,042(+) TCTAG(A/G/T)CAGGA intron-variant
rs7254364 -- 45,869,960(+) tttgt(A/G)ttttt intron-variant
rs7254848 -- 45,869,795(+) tattt(A/T)ttttt intron-variant
rs8103278 -- 45,867,123(+) CTTCC(A/G)GGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOXA3 Gene

Variant ID Type Subtype PubMed ID
dgv3956n71 CNV Loss 21882294
nsv912172 CNV Loss 21882294
nsv510770 CNV Loss 20534489
nsv523029 CNV Loss 19592680

Relevant External Links for FOXA3 Gene

HapMap Linkage Disequilibrium report
FOXA3
Human Gene Mutation Database (HGMD)
FOXA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXA3 Gene

Disorders for FOXA3 Gene

Relevant External Links for FOXA3

Genetic Association Database (GAD)
FOXA3
Human Genome Epidemiology (HuGE) Navigator
FOXA3

No disorders were found for FOXA3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FOXA3 Gene

Publications for FOXA3 Gene

  1. Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma. (PMID: 12695546) Rodriguez-Antona C. … Castell J.V. (Mol. Pharmacol. 2003) 3 4 23
  2. Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq. (PMID: 19919681) Motallebipour M. … Wadelius C. (Genome Biol. 2009) 3 4 23
  3. Genetic predictors of interindividual variability in hepatic CYP3A4 expression. (PMID: 19934400) Lamba V. … Schuetz E.G. (J. Pharmacol. Exp. Ther. 2010) 3 48
  4. Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. (PMID: 8332212) Clark K.L. … Burley S.K. (Nature 1993) 3 4
  5. Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells. (PMID: 8499623) Hromas R. … Klemsz M. (Blood 1993) 3 4

Products for FOXA3 Gene

Sources for FOXA3 Gene

Back to Top

Content