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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FOXA3 Gene

protein-coding   GIFtS: 54
GCID: GC19P046368

forkhead box A3

(Previous names: hepatocyte nuclear factor 3, gamma )
(Previous symbol: HNF3G)
 Explore 4 diseases affiliated with
FOXA3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FOXA3    

Aliases
for FOXA3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Forkhead Box A31 2     HNF-3-Gamma1
HNF3G1 2 3 5     HNF-3G2 3
Hepatocyte Nuclear Factor 3, Gamma1 2     TCF-3G2 3
Fork Head-Related Protein FKH H32 3     TCF3G2 3
Forkhead Box Protein A32 3     FKHH32
Transcription Factor 3G2 3     Hepatocyte Nuclear Factor 3-Gamma2

External Ids:    HGNC: 50231   Entrez Gene: 31712   Ensembl: ENSG000001706087   OMIM: 6022955   UniProtKB: P553183   

Export aliases for FOXA3 gene to outside databases

Previous GC identifers: GC19P047011 GC19P046758 GC19P051043 GC19P051059 GC19P042796


Summaries
for FOXA3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FOXA3:
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are
transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact
with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation
of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: FOXA3_HUMAN, P55318
Function: Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other
proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer
and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes
such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these
genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the
CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with
members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in
regulation of spermatogenesis

Gene Wiki entry for FOXA3


Genomic Views
for FOXA3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FOXA3 gene promoter:
         NF-1/L   NF-1   USF1   Olf-1   Ik-3   E2F-1   E2F   USF-1   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FOXA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FOXA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2-q13.4   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.2-q13.4

FOXA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXA3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P046368:  view genomic region     (about GC identifiers)

Start:
 46,367,518 bp from pter      End:
 46,377,055 bp from pter
Size:
 9,538 bases      Orientation:
 plus strand

Proteins
for FOXA3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FOXA3_HUMAN, P55318 (See protein sequence)
Recommended Name: Hepatocyte nuclear factor 3-gamma  
Size: 350 amino acids; 37140 Da
Subunit: Interacts with FOXA2
Subcellular location: Nucleus
Developmental stage: Detected in prenatal liver nuclear extracts (12.4-27 weeks estimated gestational age). Not
detected in postnatal liver samples
1 PDB 3D structure from and Proteopedia for FOXA3:
1VTN (3D)    
Secondary accessions: A9LYI5 Q53F16 Q9UMW9

Explore the universe of human proteins at neXtProt for FOXA3: NX_P55318

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P55318

    • FOXA3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004488.2  
    ENSEMBL proteins: 
     ENSP00000304004  
    Reactome Protein details: P55318
    Human Recombinant Protein Products: 
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    Uscn Proteins for FOXA3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS7739897
    GO:0005667transcription factor complex IBA--
    GO:0044428nuclear part ----


    FOXA3 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for FOXA3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FOXA3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR018533 Forkhead_box_C
     IPR018122 TF_fork_head_CS
     IPR013638 Fork-head_N
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry P55318

    ProtoNet protein and cluster: P55318

    1 Blocks protein family: IPB013638 Fork-head N-terminal

    UniProtKB/Swiss-Prot: FOXA3_HUMAN, P55318
    Similarity: Contains 1 fork-head DNA-binding domain


    Function
    for FOXA3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FOXA3_HUMAN, P55318
    Function: Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other
    proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer
    and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes
    such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these
    genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the
    CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with
    members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in
    regulation of spermatogenesis

    miRNA
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    hsa-miR-3926 hsa-miR-4286 hsa-miR-222* hsa-miR-936 hsa-miR-575 hsa-miR-3919 hsa-miR-548s
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9369482
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IBA--
    GO:0008134transcription factor binding IBA--


    FOXA3 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for FOXA3:
     Increased circadian period len  Increased homologous recombina 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Foxa3):
     normal 

    FOXA3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FOXA3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of beta-cell development
    		Regulation of beta-cell development1.00
    		Regulation of gene expression in beta cells0.56
    		Maturity onset diabetes of the young0.56
    2HNF1A-dependent synthesis of FOXA3
    		HNF1A-dependent synthesis of FOXA31.00
    		FOXA transcription factor networks0.33
    3FOXA1 transcription factor network
    		FOXA1 transcription factor network1.00
    4FOXA2 and FOXA3 transcription factor networks
    		FOXA2 and FOXA3 transcription factor networks1.00
    5Axon guidance
    		Developmental Biology0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 BioSystems Pathways for FOXA3 
        FOXA2 and FOXA3 transcription factor networks
    FOXA1 transcription factor network
    FOXA transcription factor networks

    4        Reactome Pathways for FOXA3
        Regulation of gene expression in beta cells
    Developmental Biology
    Regulation of beta-cell development
    HNF1A-dependent synthesis of FOXA3


    1         Kegg Pathway  (Kegg details for FOXA3):
        Maturity onset diabetes of the young


    FOXA3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/13 Interacting proteins for FOXA3 (P553183 ENSP000003040044) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALX4Q9H1613, ENSP000003327444I2D: score=1 STRING: ENSP00000332744
    HMGB1P094293, ENSP000003430404I2D: score=1 STRING: ENSP00000343040
    TLE1Q047243, ENSP000003656824I2D: score=1 STRING: ENSP00000365682
    TLE2Q047253, ENSP000002629534I2D: score=1 STRING: ENSP00000262953
    AFPENSP000002263594STRING: ENSP00000226359
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001678cellular glucose homeostasis TAS9369482
    GO:0006351transcription, DNA-dependent ----
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0007283spermatogenesis IEA--


    FOXA3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FOXA3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for FOXA3
    Search CenterWatch for drugs/clinical trials and news about FOXA3 

    Transcripts
    for FOXA3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FOXA3 gene: 
    NM_004497.2  

    Unigene Cluster for FOXA3:

    Forkhead box A3
    Hs.36137  [show with all ESTs]
    Unigene Representative Sequence: NM_004497
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000302177(uc002pdr.3)

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    hsa-miR-3926 hsa-miR-4286 hsa-miR-222* hsa-miR-936 hsa-miR-575 hsa-miR-3919 hsa-miR-548s
    SwitchGear 3'UTR luciferase reporter plasmid: FOXA3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK223473.1 BC016024.1 BT006720.1 L12141.1 

    2 DOTS entries:

    DT.108893  DT.91734279 

    24/41 AceView cDNA sequences (see all 41):

    BX117799 BM823797 CK903678 BQ008998 BM853521 BC016024 CK903679 BM824196 
    BQ082743 AW582880 BQ083358 AA468705 BT006720 NM_004497 AI765153 AI867382 
    AI991177 BP342940 BU622157 AI983401 BM796739 AI310431 BM825618 AA602377 

    GeneLoc Exon Structure


    Expression
    for FOXA3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FOXA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGTTGGGTAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FOXA3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/12 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 12) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneZeugopod Epiphyseal EndChondrocytesBone, Cartilage
    Gut TubeForegutForegut Endoderm CellsEndoderm
    Gut TubeGut TubePrimitive Gut Endoderm CellsEndoderm
    Gut TubeHindgutHindgut Endoderm CellsEndoderm
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    Gut TubeVentral Foregut EndodermHepatic Endoderm CellsLiver
    Gut TubeVentral Foregut EndodermVentral Foregut Endoderm CellsEndoderm
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    LiverLiver LobuleHepatocytesLiver
    LiverLiver LobuleMature HepatocytesLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Endoderm progenitor-like cells (Generation and expan...)
    Definitive endoderm like cells (Efficient derivation...)

    See FOXA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FOXA3

    SOURCE GeneReport for Unigene cluster: Hs.36137

    UniProtKB/Swiss-Prot: FOXA3_HUMAN, P55318
    Tissue specificity: Expressed in erythroleukemia and hepatoma cell lines and in liver and pancreas. Not expressed in
    any other cell lines or tissues examined

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    In Situ
    Assay Products:     
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    Orthologs
    for FOXA3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FOXA3 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia FOXA36
    		 --
    		 34(a)
    		 1 ↔ 1
    		 GL344028.1(14981-16165)
    zebrafish
    (Danio rerio)    		 Actinopterygii foxa32 forkhead box A3 78.8(n)   30559  AF052245.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta fkh6
    		 fork head
    		 23(a)
    		 1 → many
    		 3R(24406805-24410834)
    worm
    (Caenorhabditis elegans)    		 Secernentea pha-46
    		 Defective pharyngeal development protein 4
    		 20(a)
    		 1 → many
    		 V(20752905-20760272)


    ENSEMBL Gene Tree for FOXA3 (if available)
    TreeFam Gene Tree for FOXA3 (if available) 

    Paralogs
    for FOXA3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FOXA3 gene
    FOXF12  FOXA22  FOXD4L12  FOXF22  FOXC22  FOXB12  FOXI22  FOXE32  
    FOXC12  FOXD4L22  FOXQ12  FOXD4L32  FOXD12  FOXD32  FOXD4L52  FOXD4L42  
    FOXE12  FOXL12  FOXA12  FOXB22  FOXI12  FOXD4L62  FOXS12  FOXD22  
    FOXL22  FOXD42  
    11 SIMAP similar genes for FOXA3 using alignment to 2 protein entries:     FOXA3_HUMAN (see all proteins):
    FOXB1    FOXB2    FOXD1    FOXS1    FOXD2    FOXC1
    FOXE1    FOXA2    FOXC2    FOXA1    FOXE3

    FOXA3 for paralogs           About GeneDecksing



    Genomic Variants
    for FOXA3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/210 NCBI SNPs in FOXA3 are shown (see all 210)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs81125941,2
    		C,F,A,H,--46365672(+) aacatT/Cagctg 2 -- us2k1 int115Minor allele frequency- C:0.11NS EA NA WA CSA 877
    rs116733731,2
    		C,F,H,--46365694(+) CGTGAT/CTGGCG 2 -- us2k1 int1 tfbs38Minor allele frequency- C:0.12NA NS WA EA 448
    rs1844346691,2
    		--46365744(+) CCCTAA/CCTTCA 2 -- int1 us2k10--------
    rs616756531,2
    		C,--46365907(+) GAAGTG/AACGTT 2 -- int1 us2k13Minor allele frequency- A:0.01NS NA 204
    rs358501021,2
    		C,F,--46365970(+) AGGATG/ATTGCA 2 -- us2k1 int18Minor allele frequency- A:0.05NA NS WA 330
    rs340862571,2
    		C,F,--46366279(+) TCCTCC/GTTTCG 2 -- us2k1 int15Minor allele frequency- G:0.07NA 306
    rs1479277611,2
    		--46366330(+) GGCCTC/TCGTTC 2 -- ut51 us2k10--------
    rs38409321,2
    		C--46366372(-) GGCGG-/CGGCGGCG 3 -- us2k1 ut511Minor allele frequency- CGG:0.50CSA 2
    rs1510458531,2
    		C,--46366372(+) ACACT-/CCGCCGCC 2 -- ut51 us2k10--------
    rs72473601,2
    		C,--46366389(+) CCGCCA/GCCATC 2 -- ut51 us2k10--------

    HapMap Linkage Disequilibrium report for FOXA3 (46367518 - 46377055 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FOXA3: --
    Human Gene Mutation Database (HGMD): FOXA3

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for FOXA3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FOXA3 for disorders           About GeneDecksing

    OMIM gene information: 602295    OMIM disorders: --

    4 diseases for FOXA3:    About MalaCards
    maturity-onset diabetes of the young    pharyngitis    hepatitis    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: FOXA3 (1 document)

    Export disorders for FOXA3 gene to outside databases

    Publications
    for FOXA3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FOXA3 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with FOXA3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq. (PubMed id 19919681)1, 2, 9 Motallebipour M.... Wadelius C. (2009)
    2. Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma. (PubMed id 12695546)1, 2, 9 Rodriguez-Antona C....Castell J.V. (2003)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis. (PubMed id 10899756)1, 2 Navas M.A....Stoffel M. (2000)
    5. The role of HNF1alpha, HNF3gamma, and cyclic AMP in glucose-6-phosphatase gene activation. (PubMed id 9369482)1, 2 Lin B....Chou J.Y. (1997)
    6. Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4. (PubMed id 9119385)1, 3 Mincheva A....Kaestner K.H. (1997)
    7. Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. (PubMed id 8332212)1, 2 Clark K.L....Burley S.K. (1993)
    8. Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells. (PubMed id 8499623)1, 2 Hromas R.... Klemsz M. (1993)
    9. [Caloric restriction suppresses endothelial cells sene scence via down-regulation of NOX4 induced by HNF3g]. (PubMed id 22659429)1 Liu Q....Wang J. (2012)
    10. Genetic predictors of interindividual variability in hepatic CYP3A4 expression. (PubMed id 19934400)1 Lamba V....Schuetz E.G. (2010)

    External Searches for FOXA3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing FOXA3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3171 HGNC: 5023 AceView: FOXA3 Ensembl:ENSG00000170608 euGenes: HUgn3171
    ECgene: FOXA3 Kegg: 3171 H-InvDB: FOXA3

    Other Databases showing FOXA3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FOXA3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FOXA3 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Hepatocyte_nuclear_factors
    SeattleSNPshttp://pga.gs.washington.edu/data/foxa3/

    Intellectual Property
    for FOXA3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FOXA3 gene:
    Search GeneIP for patents involving FOXA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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