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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FOXA3 Gene

protein-coding GIFtS: 54
GCID: GC19P046368

forkhead box A3

(Previous names: hepatocyte nuclear factor 3, gamma )
(Previous symbol: HNF3G)

Explore 4 diseases affiliated with
FOXA3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Forkhead Box A3¹ ²		HNF-3-Gamma¹
HNF3G¹ ² ³ ⁵		HNF-3G² ³
Hepatocyte Nuclear Factor 3, Gamma¹ ²		TCF-3G² ³
Fork Head-Related Protein FKH H3² ³		TCF3G² ³
Forkhead Box Protein A3² ³		FKHH3²
Transcription Factor 3G² ³		Hepatocyte Nuclear Factor 3-Gamma²

External Ids:	HGNC: 5023¹	Entrez Gene: 3171²	Ensembl: ENSG00000170608⁷	OMIM: 602295⁵	UniProtKB: P55318³

Export aliases for FOXA3 gene to outside databases

Previous GC identifers: GC19P047011 GC19P046758 GC19P051043 GC19P051059 GC19P042796

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FOXA3:

This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are

transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact

with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation

of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. (provided by RefSeq,

Jul 2008)

UniProtKB/Swiss-Prot: FOXA3_HUMAN, P55318

Function: Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other

proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer

and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes

such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these

genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the

CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with

members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in

regulation of spermatogenesis

Gene Wiki entry for FOXA3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FOXA3 gene promoter:
NF-1/L NF-1 USF1 Olf-1 Ik-3 E2F-1 E2F USF-1 ZID
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FOXA3 promoter sequence

Search SABiosciences Chromatin IP Primers for FOXA3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXA3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2-q13.4 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.2-q13.4

FOXA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXA3 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P046368: view genomic region (about GC identifiers)

Start:	46,367,518 bp from pter	End:	46,377,055 bp from pter
Size:	9,538 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FOXA3_HUMAN, P55318 (See protein sequence)

Recommended Name: Hepatocyte nuclear factor 3-gamma

Size: 350 amino acids; 37140 Da

Subunit: Interacts with FOXA2

Subcellular location: Nucleus

Developmental stage: Detected in prenatal liver nuclear extracts (12.4-27 weeks estimated gestational age). Not

detected in postnatal liver samples

1 PDB 3D structure from and Proteopedia for FOXA3:

1VTN (3D)

Secondary accessions: A9LYI5 Q53F16 Q9UMW9

Explore the universe of human proteins at neXtProt for FOXA3: NX_P55318

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P55318

FOXA3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004488.2

ENSEMBL proteins:

ENSP00000304004

Reactome Protein details: P55318
Human Recombinant Protein Products for FOXA3:

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	Uscn Proteins for FOXA3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	7739897
GO:0005667	transcription factor complex	IBA	--
GO:0044428	nuclear part	--	--

FOXA3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FOXA3 for domains About GeneDecksing

5 InterPro domains/families:

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR018533 Forkhead_box_C

IPR018122 TF_fork_head_CS

IPR013638 Fork-head_N

IPR001766 TF_fork_head

Graphical View of Domain Structure for InterPro Entry P55318

ProtoNet protein and cluster: P55318

1 Blocks protein family: IPB013638 Fork-head N-terminal

UniProtKB/Swiss-Prot: FOXA3_HUMAN, P55318

Similarity: Contains 1 fork-head DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: FOXA3_HUMAN, P55318

Function: Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other

proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer

and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes

such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these

genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the

CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with

members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in

regulation of spermatogenesis

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003690	double-stranded DNA binding	IBA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	9369482
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	IBA	--
GO:0008134	transcription factor binding	IBA	--

FOXA3 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for FOXA3:

Increased circadian period len

Increased homologous recombina

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Foxa3):

normal

FOXA3 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FOXA3

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Regulation of beta-cell development

	Regulation of beta-cell development	1.00			Regulation of gene expression in beta cells	0.56
	Maturity onset diabetes of the young	0.56

HNF1A-dependent synthesis of FOXA3

HNF1A-dependent synthesis of FOXA3

1.00

FOXA transcription factor networks

0.33

FOXA1 transcription factor network

FOXA1 transcription factor network

1.00

FOXA2 and FOXA3 transcription factor networks

FOXA2 and FOXA3 transcription factor networks

1.00

Axon guidance

Developmental Biology

0.69

Pathway sources
See GeneCards unified pathways
Show all pathways

3 BioSystems Pathways for FOXA3

	FOXA2 and FOXA3 transcription factor networks
	FOXA1 transcription factor network
	FOXA transcription factor networks

4 Reactome Pathways for FOXA3

	Regulation of gene expression in beta cells
	Developmental Biology
	Regulation of beta-cell development
	HNF1A-dependent synthesis of FOXA3

1 Kegg Pathway (Kegg details for FOXA3):

Maturity onset diabetes of the young

FOXA3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FOXA3

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

12/13 Interacting proteins for FOXA3 (P55318³ ENSP00000304004⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13) (see top 5)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ALX4	Q9H161³, ENSP00000332744⁴	I2D: score=1 STRING: ENSP00000332744
HMGB1	P09429³, ENSP00000343040⁴	I2D: score=1 STRING: ENSP00000343040
TLE1	Q04724³, ENSP00000365682⁴	I2D: score=1 STRING: ENSP00000365682
TLE2	Q04725³, ENSP00000262953⁴	I2D: score=1 STRING: ENSP00000262953
AFP	ENSP00000226359⁴	STRING: ENSP00000226359
ALB	ENSP00000295897⁴	STRING: ENSP00000295897
G6PC	ENSP00000253801⁴	STRING: ENSP00000253801
PCK1	ENSP00000319814⁴	STRING: ENSP00000319814
TAT	ENSP00000348234⁴	STRING: ENSP00000348234
TTR	ENSP00000237014⁴	STRING: ENSP00000237014
C4BPB	ENSP00000243611⁴	STRING: ENSP00000243611
TFRC	ENSP00000353224⁴	STRING: ENSP00000353224

About this table

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001678	cellular glucose homeostasis	TAS	9369482
GO:0006351	transcription, DNA-dependent	--	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	--	--
GO:0007283	spermatogenesis	IEA	--

FOXA3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FOXA3
Search CenterWatch for drugs/clinical trials and news about FOXA3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FOXA3 gene:

NM_004497.2

Unigene Cluster for FOXA3:

Forkhead box A3

Hs.36137 [show with all ESTs]

Unigene Representative Sequence: NM_004497

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000302177(uc002pdr.3)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOXA3
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXA3:
		hsa-miR-3926 hsa-miR-4286 hsa-miR-222* hsa-miR-936 hsa-miR-575 hsa-miR-3919 hsa-miR-548s
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Additional cDNA sequence:

AK223473.1 BC016024.1 BT006720.1 L12141.1

2 DOTS entries:

DT.108893 DT.91734279

24/41 AceView cDNA sequences (see all 41):

BX117799 BM823797 CK903678 BQ008998 BM853521 BC016024 CK903679 BM824196

BQ082743 AW582880 BQ083358 AA468705 BT006720 NM_004497 AI765153 AI867382

AI991177 BP342940 BU622157 AI983401 BM796739 AI310431 BM825618 AA602377

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FOXA3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTTGGGTAG

About this image

FOXA3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/12 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 12)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Zeugopod Epiphyseal End

Chondrocytes

Bone, Cartilage

Gut Tube

Foregut

Foregut Endoderm Cells

Endoderm

Gut Tube

Primitive Gut Endoderm Cells

Endoderm

Gut Tube

Hindgut

Hindgut Endoderm Cells

Endoderm

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Gut Tube

Ventral Foregut Endoderm

Hepatic Endoderm Cells

Liver

Gut Tube

Ventral Foregut Endoderm

Ventral Foregut Endoderm Cells

Endoderm

Limb

Zeugopod

Mesenchymal Condensate Cells

Bone, Cartilage

Liver

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Endoderm progenitor-like cells (Generation and expan...)

Definitive endoderm like cells (Efficient derivation...)

See FOXA3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FOXA3

SOURCE GeneReport for Unigene cluster: Hs.36137

UniProtKB/Swiss-Prot: FOXA3_HUMAN, P55318

Tissue specificity: Expressed in erythroleukemia and hepatoma cell lines and in liver and pancreas. Not expressed in

any other cell lines or tissues examined

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FOXA3 gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	FOXA3⁶	--	34(a)	1 ↔ 1	GL344028.1(14981-16165)
zebrafish (Danio rerio)	Actinopterygii	foxa3²	forkhead box A3	78.8(n)		30559 AF052245.1
fruit fly (Drosophila melanogaster)	Insecta	fkh⁶	fork head	23(a)	1 → many	3R(24406805-24410834)
worm (Caenorhabditis elegans)	Secernentea	pha-4⁶	Defective pharyngeal development protein 4	20(a)	1 → many	V(20752905-20760272)

ENSEMBL Gene Tree for FOXA3 (if available)
TreeFam Gene Tree for FOXA3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FOXA3 gene

FOXF1² FOXA2² FOXD4L1² FOXF2² FOXC2² FOXB1² FOXI2² FOXE3²

FOXC1² FOXD4L2² FOXQ1² FOXD4L3² FOXD1² FOXD3² FOXD4L5² FOXD4L4²

FOXE1² FOXL1² FOXA1² FOXB2² FOXI1² FOXD4L6² FOXS1² FOXD2²

FOXL2² FOXD4²

11 SIMAP similar genes for FOXA3 using alignment to 2 protein entries: FOXA3_HUMAN (see all proteins):

FOXB1 FOXB2 FOXD1 FOXS1 FOXD2 FOXC1

FOXE1 FOXA2 FOXC2 FOXA1 FOXE3

FOXA3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs8112594^1,2	C,F,A,H	--	46365672(+)	`aacatT/Cagctg`	2	--	us2k¹ int¹		15		NS EA NA WA CSA	877
rs11673373^1,2	C,F,H	--	46365694(+)	`CGTGAT/CTGGCG`	2	--	us2k¹ int¹ tfbs³		8		NA NS WA EA	448
rs184434669^1,2		--	46365744(+)	`CCCTAA/CCTTCA`	2	--	int¹ us2k¹		0	--	--	--	--
rs61675653^1,2	C	--	46365907(+)	`GAAGTG/AACGTT`	2	--	int¹ us2k¹		3		NS NA	204
rs35850102^1,2	C,F	--	46365970(+)	`AGGATG/ATTGCA`	2	--	us2k¹ int¹		8		NA NS WA	330
rs34086257^1,2	C,F	--	46366279(+)	`TCCTCC/GTTTCG`	2	--	us2k¹ int¹		5		NA	306
rs147927761^1,2		--	46366330(+)	`GGCCTC/TCGTTC`	2	--	ut5¹ us2k¹		0	--	--	--	--
rs3840932^1,2	C	--	46366372(-)	`GGCGG-/CGGCGGCG`	3	--	us2k¹ ut5¹		1		CSA	2
rs151045853^1,2	C	--	46366372(+)	`ACACT-/CCGCCGCC`	2	--	ut5¹ us2k¹		0	--	--	--	--
rs7247360^1,2	C	--	46366389(+)	`CCGCCA/GCCATC`	2	--	ut5¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FOXA3 (46367518 - 46377055 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FOXA3: --
Human Gene Mutation Database (HGMD): FOXA3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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FOXA3 for disorders           About GeneDecksing

OMIM gene information: 602295    OMIM disorders: --

4 diseases for FOXA3:    About MalaCards

maturity-onset diabetes of the young pharyngitis hepatitis neuronitis

Human Genome Epidemiology (HuGE) Navigator: FOXA3 (1 document)

Export disorders for FOXA3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FOXA3 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with FOXA3)

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Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq. (PubMed id 19919681)^{1, 2, 9} Motallebipour M.... Wadelius C. (2009)
Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma. (PubMed id 12695546)^{1, 2, 9} Rodriguez-Antona C....Castell J.V. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis. (PubMed id 10899756)^{1, 2} Navas M.A....Stoffel M. (2000)
The role of HNF1alpha, HNF3gamma, and cyclic AMP in glucose-6-phosphatase gene activation. (PubMed id 9369482)^{1, 2} Lin B....Chou J.Y. (1997)
Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4. (PubMed id 9119385)^{1, 3} Mincheva A....Kaestner K.H. (1997)
Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. (PubMed id 8332212)^{1, 2} Clark K.L....Burley S.K. (1993)
Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells. (PubMed id 8499623)^{1, 2} Hromas R.... Klemsz M. (1993)
[Caloric restriction suppresses endothelial cells sene scence via down-regulation of NOX4 induced by HNF3g]. (PubMed id 22659429)¹ Liu Q....Wang J. (2012)
Genetic predictors of interindividual variability in hepatic CYP3A4 expression. (PubMed id 19934400)¹ Lamba V....Schuetz E.G. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3171	HGNC: 5023	AceView: FOXA3	Ensembl:ENSG00000170608	euGenes: HUgn3171
ECgene: FOXA3	Kegg: 3171	H-InvDB: FOXA3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FOXA3	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Hepatocyte_nuclear_factors
SeattleSNPs	http://pga.gs.washington.edu/data/foxa3/

Intellectual Property for FOXA3 gene
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Patent Information for FOXA3 gene:
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