Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FOXA3 Gene

protein-coding   GIFtS: 58
GCID: GC19P046368

Forkhead Box A3

(Previous names: hepatocyte nuclear factor 3, gamma)
(Previous symbol: HNF3G)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Forkhead Box A31 2     HNF-3-gamma2 3
HNF3G1 2 3 5     HNF-3G2 3
Hepatocyte Nuclear Factor 3, Gamma1 2     TCF-3G2 3
Fork Head-Related Protein FKH H32 3     TCF3G2 3
Forkhead Box Protein A32 3     FKHH32
Transcription Factor 3G2 3     Hepatocyte Nuclear Factor 3-Gamma2

External Ids:    HGNC: 50231   Entrez Gene: 31712   Ensembl: ENSG000001706087   OMIM: 6022955   UniProtKB: P553183   

Export aliases for FOXA3 gene to outside databases

Previous GC identifers: GC19P047011 GC19P046758 GC19P051043 GC19P051059 GC19P042796


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FOXA3 Gene:
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are
transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also
interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the
differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved.
(provided by RefSeq, Jul 2008)

GeneCards Summary for FOXA3 Gene: 
FOXA3 (forkhead box A3) is a protein-coding gene. Diseases associated with FOXA3 include pharyngitis, and maturity-onset diabetes of the young, and among its related super-pathways are Regulation of beta-cell development and Axon guidance. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXF1.

UniProtKB/Swiss-Prot: FOXA3_HUMAN, P55318
Function: Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for
other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at
target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a
number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting
regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the
G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to
the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific
transcription. May be involved in regulation of spermatogenesis

Gene Wiki entry for FOXA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FOXA3 gene promoter:
         NF-1/L   NF-1   USF1   Olf-1   Ik-3   E2F-1   E2F   USF-1   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOXA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FOXA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2-q13.4   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.2-q13.4

FOXA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXA3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P046368:  view genomic region     (about GC identifiers)

Start:
46,367,247 bp from pter      End:
46,377,055 bp from pter
Size:
9,809 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FOXA3_HUMAN, P55318 (See protein sequence)
Recommended Name: Hepatocyte nuclear factor 3-gamma  
Size: 350 amino acids; 37140 Da
Subunit: Interacts with FOXA2
Subcellular location: Nucleus
Developmental stage: Detected in prenatal liver nuclear extracts (12.4-27 weeks estimated gestational age). Not
detected in postnatal liver samples
1 PDB 3D structure from and Proteopedia for FOXA3:
1VTN (3D)    
Secondary accessions: A9LYI5 Q53F16 Q9UMW9

Explore the universe of human proteins at neXtProt for FOXA3: NX_P55318

Explore proteomics data for FOXA3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P55318

  • FOXA3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FOXA3 Protein Expression
    REFSEQ proteins: NP_004488.2  
    ENSEMBL proteins: 
     ENSP00000470816   ENSP00000304004  
    Reactome Protein details: P55318
    Human Recombinant Protein Products for FOXA3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FOXA3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for FOXA3
    GenScript Custom Purified and Recombinant Proteins Services for FOXA3
    Novus Biologicals FOXA3 Proteins
    Novus Biologicals FOXA3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FOXA3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IBA--

    FOXA3 for ontologies           About GeneDecksing



    FOXA3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FOXA3
    GenScript Custom Superior Antibodies Services for FOXA3
    Novus Biologicals FOXA3 Antibodies
    Abcam antibodies for FOXA3
    Cloud-Clone Corp. Antibodies for FOXA3 
    ThermoFisher Antibodies for FOXA3
    LSBio Antibodies in human, mouse, rat for FOXA3 

    Assay Products for FOXA3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FOXA3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FOXA3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FOXA3 
    Cloud-Clone Corp. CLIAs for FOXA3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FOX: Forkhead boxes

    5 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR018533 Forkhead_box_C
     IPR018122 TF_fork_head_CS
     IPR013638 Fork-head_N
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry P55318

    ProtoNet protein and cluster: P55318

    1 Blocks protein domain: IPB013638 Fork-head N-terminal

    UniProtKB/Swiss-Prot: FOXA3_HUMAN, P55318
    Similarity: Contains 1 fork-head DNA-binding domain


    FOXA3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXA3_HUMAN, P55318
    Function: Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for
    other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at
    target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a
    number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting
    regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the
    G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to
    the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific
    transcription. May be involved in regulation of spermatogenesis

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9369482
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IBA--
    GO:0008134transcription factor binding IBA--
         
    FOXA3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FOXA3:
     Increased circadian period len  Increased homologous recombina 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Foxa3):
     normal 

    FOXA3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FOXA3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FOXA3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FOXA3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FOXA3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOXA3
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXA3:
    hsa-miR-3926 hsa-miR-4286 hsa-miR-222* hsa-miR-936 hsa-miR-575 hsa-miR-3919 hsa-miR-548s
    SwitchGear 3'UTR luciferase reporter plasmidFOXA3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FOXA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXA3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FOXA3
    Sirion Biotech Customized adenovirus for overexpression of FOXA3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FOXA3 (see all 6)
    OriGene ORF clones in mouse, rat for FOXA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FOXA3 (NM_004497)
    Sino Biological Human cDNA Clone for FOXA3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXA3
    Sirion Biotech Customized lentivirus for stable overexpression of FOXA3 
                         Customized lentivirus expression plasmids for stable overexpression of FOXA3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FOXA3
    Search LifeMap BioReagents cell lines for FOXA3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXA3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FOXA3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of beta-cell development
    Regulation of beta-cell development0.56
    Regulation of gene expression in beta cells0.56
    Maturity onset diabetes of the young0.56
    2Axon guidance
    Developmental Biology0.69
    3FOXA2 and FOXA3 transcription factor networks
    FOXA2 and FOXA3 transcription factor networks
    4FOXA1 transcription factor network
    FOXA1 transcription factor network
    5FOXA transcription factor networks
    FOXA transcription factor networks

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for FOXA3
        FOXA2 and FOXA3 transcription factor networks
    FOXA1 transcription factor network
    FOXA transcription factor networks


    3        Reactome Pathways for FOXA3
        Regulation of gene expression in beta cells
    Developmental Biology
    Regulation of beta-cell development


    1         Kegg Pathway  (Kegg details for FOXA3):
        Maturity onset diabetes of the young


    FOXA3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOXA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/13 Interacting proteins for FOXA3 (P553183 ENSP000003040044) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALX4Q9H1613, ENSP000003327444I2D: score=1 STRING: ENSP00000332744
    HMGB1P094293, ENSP000003430404I2D: score=1 STRING: ENSP00000343040
    TLE1Q047243, ENSP000003656824I2D: score=1 STRING: ENSP00000365682
    TLE2Q047253, ENSP000002629534I2D: score=1 STRING: ENSP00000262953
    AFPENSP000002263594STRING: ENSP00000226359
    About this table

    Gene Ontology (GO): 20 biological process terms (GO ID links to tree view) (see first 5):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IBA--
    GO:0001678cellular glucose homeostasis TAS9369482
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0007283spermatogenesis IEA--
    GO:0007389pattern specification process IBA--
    GO:0007420brain development ----
    GO:0008285negative regulation of cell proliferation ----
    GO:0009267cellular response to starvation IEA--
    GO:0009790embryo development IBA--
    GO:0009888tissue development IBA--
    GO:0010817regulation of hormone levels IBA--
    GO:0016568chromatin modification IEA--
    GO:0021999neural plate anterior/posterior regionalization ----
    GO:0031018endocrine pancreas development TAS--
    GO:0045666positive regulation of neuron differentiation IBA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA12695546
    GO:0048665neuron fate specification IBA--
    GO:0051090regulation of sequence-specific DNA binding transcription factor activity IBA--
    GO:0070368positive regulation of hepatocyte differentiation ----

    FOXA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FOXA3

    Search CenterWatch for drugs/clinical trials and news about FOXA3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FOXA3 gene: 
    NM_004497.2  

    Unigene Cluster for FOXA3:

    Forkhead box A3
    Hs.36137  [show with all ESTs]
    Unigene Representative Sequence: NM_004497
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000594297 ENST00000302177(uc002pdr.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOXA3
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate FOXA3:
    hsa-miR-3926 hsa-miR-4286 hsa-miR-222* hsa-miR-936 hsa-miR-575 hsa-miR-3919 hsa-miR-548s
    SwitchGear 3'UTR luciferase reporter plasmidFOXA3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FOXA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXA3
    Clone
    Products:
         
    OriGene clones in human, mouse for FOXA3 (see all 6)
    OriGene ORF clones in mouse, rat for FOXA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FOXA3 (NM_004497)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOXA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXA3
    Sirion Biotech Customized lentivirus for stable overexpression of FOXA3 
                         Customized lentivirus expression plasmids for stable overexpression of FOXA3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FOXA3
    OriGene qSTAR qPCR primer pairs in human, mouse for FOXA3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FOXA3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXA3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXA3

    Additional mRNA sequence: 

    AK223473.1 BC016024.1 BT006720.1 L12141.1 

    2 DOTS entries:

    DT.108893  DT.91734279 

    24/41 AceView cDNA sequences (see all 41):

    BC016024 NM_004497 BT006720 BQ008998 BM824196 BQ082743 CK903678 BQ083358 
    BM823797 AI765153 AA468705 BM853521 CK903679 AW582880 BX117799 BI963714 
    AI991177 T25070 BM825618 BM826786 AV697549 BM766874 AI983401 AA602377 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FOXA3 expression in normal human tissues (normalized intensities)      FOXA3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTTGGGTAG
    FOXA3 Expression
    About this image


    FOXA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/36 selected tissues (see all 36) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 7 entries
             Hepatic Endoderm Cells Ventral Foregut Endoderm
             Endoderm progenitor-like cells ( Generation and expansion of endodermal progenitor...
     
     Liver (Hepatobiliary System)    fully expand to see all 5 entries
             Mature Hepatocytes Liver Lobule
             liver ; bile duct cells   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Lung (Respiratory System)    fully expand to see all 4 entries
             Mucus-producing Cells Respiratory Bronchioles
             lung ; pneumocytes   

    See FOXA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FOXA3

    SOURCE GeneReport for Unigene cluster: Hs.36137

    UniProtKB/Swiss-Prot: FOXA3_HUMAN, P55318
    Tissue specificity: Expressed in erythroleukemia and hepatoma cell lines and in liver and pancreas. Not expressed
    in any other cell lines or tissues examined

        SABiosciences Custom PCR Arrays for FOXA3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FOXA3
    OriGene qSTAR qPCR primer pairs in human, mouse for FOXA3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FOXA3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXA3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXA3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FOXA3 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxa31 , 5 forkhead box A31, 5 85(n)1
    89.68(a)1
      7 (9.46 cM)5
    153771  NM_008260.21  NP_032286.11 
     190132825 
    lizard
    (Anolis carolinensis)
    Reptilia FOXA36
    FOXA16
    Uncharacterized protein
    44(a)
    35(a)
    possible ortholog
    1 ↔ 1
    GL344028.1(14068-49153)
    1(25570112-25581834)
    zebrafish
    (Danio rerio)
    Actinopterygii foxa32 forkhead box A3 78.8(n)   30559  AF052245.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fkh6
    fork head
    22(a)
    1 → many
    3R(24406805-24410834)
    worm
    (Caenorhabditis elegans)
    Secernentea pha-46
    Defective pharyngeal development protein 4
    21(a)
    1 → many
    V(20752936-20760303)


    ENSEMBL Gene Tree for FOXA3 (if available)
    TreeFam Gene Tree for FOXA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FOXA3 gene
    FOXF12  FOXA22  FOXF22  FOXD4L12  FOXC22  FOXI22  FOXB12  FOXE32  
    FOXC12  FOXD4L22  FOXD4L32  FOXD4L52  FOXD12  FOXD32  FOXD4L42  FOXL12  
    FOXA12  FOXE12  FOXB22  FOXI12  FOXD4L62  FOXS12  FOXD22  FOXL22  
    FOXD42  
    9 SIMAP similar genes for FOXA3 using alignment to 2 protein entries:     FOXA3_HUMAN (see all proteins):
    FOXB1    FOXB2    FOXD1    FOXS1    FOXD2    FOXC1
    FOXE1    FOXA2    FOXC2

    FOXA3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/203 SNPs in FOXA3 are shown (see all 203)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0088594
    ----see VAR_0088592 G R mis40--------
    rs1386643741,2
    --46368660(+) GACAGA/TCAGAA 1 -- int10--------
    rs573349051,2
    C,F--46368757(+) GTTGTT/GGGGGC 1 -- int15Minor allele frequency- G:0.11NS WA NA EA 448
    rs575723011,2
    C,F--46368794(+) TTATGG/AGGGTC 1 -- int13Minor allele frequency- A:0.02NS WA 210
    rs1895792051,2
    --46368837(+) TGTGGA/GCTTGA 1 -- int10--------
    rs81126541,2
    C,F--46368977(+) CCTTCA/CGGGCT 1 -- int110Minor allele frequency- C:0.22NS NA WA EA 460
    rs1818383201,2
    --46369176(+) GTGATC/TCCAGC 1 -- int10--------
    rs48038671,2
    C,F,H--46369300(+) TCTAGA/G/TCAGGA 1 -- int112NS EA NA WA 1364
    rs1860235601,2
    --46369392(+) AAAGCA/CGGCAC 1 -- int10--------
    rs1996401301,2
    --46369505(+) TCTTT-/AAAAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for FOXA3 (46367247 - 46377055 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FOXA3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv523029CNV Loss19592680
    nsv912172CNV Loss21882294
    nsv510770CNV Loss20534489
    dgv3956n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): FOXA3
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FOXA3
    DNA2.0 Custom Variant and Variant Library Synthesis for FOXA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602295    OMIM disorders: --

    5 diseases for FOXA3:    About MalaCards
    pharyngitis    maturity-onset diabetes of the young    endotheliitis    neuronitis
    hepatitis


    FOXA3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FOXA3
    Human Genome Epidemiology (HuGE) Navigator: FOXA3 (1 document)

    Export disorders for FOXA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FOXA3 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with FOXA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq. (PubMed id 19919681)1, 2, 9 Motallebipour M.... Wadelius C. (2009)
    2. Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma. (PubMed id 12695546)1, 2, 9 Rodriguez-Antona C....Castell J.V. (2003)
    3. Genetic predictors of interindividual variability in hepatic CYP3A4 expression. (PubMed id 19934400)1, 4 Lamba V....Schuetz E.G. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis. (PubMed id 10899756)1, 2 Navas M.A....Stoffel M. (2000)
    6. The role of HNF1alpha, HNF3gamma, and cyclic AMP in glucose-6-phosphatase gene activation. (PubMed id 9369482)1, 2 Lin B....Chou J.Y. (1997)
    7. Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4. (PubMed id 9119385)1, 3 Mincheva A....Kaestner K.H. (1997)
    8. Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. (PubMed id 8332212)1, 2 Clark K.L....Burley S.K. (1993)
    9. Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells. (PubMed id 8499623)1, 2 Hromas R.... Klemsz M. (1993)
    10. [Caloric restriction suppresses endothelial cells sene scence via down-regulation of NOX4 induced by HNF3g]. (PubMed id 22659429)1 Liu Q....Wang J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3171 HGNC: 5023 AceView: FOXA3 Ensembl:ENSG00000170608 euGenes: HUgn3171
    ECgene: FOXA3 Kegg: 3171 H-InvDB: FOXA3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FOXA3 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Hepatocyte_nuclear_factors
    SeattleSNPshttp://pga.gs.washington.edu/data/foxa3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FOXA3 gene:
    Search GeneIP for patents involving FOXA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FOXA3  
     OriGene qPCR primer pairs and template standards for FOXA3   OriGene Protein Over-expression Lysate for FOXA3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FOXA3  
     OriGene qSTAR qPCR primer pairs in human, mouse for FOXA3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FOXA3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FOXA3   OriGene Custom Protein Services for FOXA3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FOXA3
     QIAGEN SeqTarget long-range PCR primers for resequencing FOXA3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXA3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOXA3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOXA3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOXA3
     GenScript Custom Purified and Recombinant Proteins Services for FOXA3 GenScript cDNA clones with any tag delivered in your preferred vector for FOXA3
     GenScript Custom Assay Services for FOXA3 GenScript Custom Superior Antibodies Services for FOXA3
     GenScript Custom overexpressing Cell Line Services for FOXA3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FOXA3 promoter
     Search Chromatin IP Primers for FOXA3
     RT2 qPCR Primer Assay in human, mouse, rat FOXA3
     Search GNC Networks for FOXA3
     SABiosciences Custom PCR Arrays for FOXA3
     Search Tocris compounds for FOXA3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for FOXA3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FOXA3 antibodies
     FOXA3 proteins
     FOXA3 lysates
     Antibodies for FOXA3
     See all of Abcam's Antibodies, Kits and Proteins for FOXA3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for FOXA3
     Antibodies for FOXA3
     ELISAs for FOXA3
     CLIAs for FOXA3
     Search LifeMap BioReagents cell lines for FOXA3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOXA3
     SwitchGear 3'UTR luciferase reporter plasmids for FOXA3
     SwitchGear Promoter luciferase reporter plasmids for FOXA3
     ThermoFisher Antibodies for FOXA3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOXA3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FOXA3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FOXA3
    Customized:
     lentivirus for stable overexpression of FOXA3
     lentivirus expression plasmids for stable overexpression of FOXA3
     adenovirus for overexpression of FOXA3
     LSBio Antibodies in human, mouse, rat for FOXA3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FOXA3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4