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FOXA3 Gene

protein-coding   GIFtS: 58
GCID: GC19P046368

Forkhead Box A3

(Previous names: hepatocyte nuclear factor 3, gamma)
(Previous symbol: HNF3G)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Forkhead Box A31 2     HNF-3-gamma2 3
HNF3G1 2 3 5     HNF-3G2 3
Hepatocyte Nuclear Factor 3, Gamma1 2     TCF-3G2 3
Fork Head-Related Protein FKH H32 3     TCF3G2 3
Forkhead Box Protein A32 3     FKHH32
Transcription Factor 3G2 3     Hepatocyte Nuclear Factor 3-Gamma2

External Ids:    HGNC: 50231   Entrez Gene: 31712   Ensembl: ENSG000001706087   OMIM: 6022955   UniProtKB: P553183   

Export aliases for FOXA3 gene to outside databases

Previous GC identifers: GC19P047011 GC19P046758 GC19P051043 GC19P051059 GC19P042796


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FOXA3 Gene:
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are
transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also
interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the
differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved.
(provided by RefSeq, Jul 2008)

GeneCards Summary for FOXA3 Gene:
FOXA3 (forkhead box A3) is a protein-coding gene. Diseases associated with FOXA3 include pharyngitis, and maturity-onset diabetes of the young. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOXA2.

UniProtKB/Swiss-Prot: FOXA3_HUMAN, P55318
Function: Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for
other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at
target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a
number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting
regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the
G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to
the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific
transcription. May be involved in regulation of spermatogenesis

Gene Wiki entry for FOXA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the FOXA3 gene promoter:
         NF-1/L   NF-1   USF1   Olf-1   Ik-3   E2F-1   E2F   USF-1   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOXA3 promoter sequence
   Search Chromatin IP Primers for FOXA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOXA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2-q13.4   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.2-q13.4

FOXA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXA3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P046368:  view genomic region     (about GC identifiers)

Start:
46,367,247 bp from pter      End:
46,377,055 bp from pter
Size:
9,809 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FOXA3_HUMAN, P55318 (See protein sequence)
Recommended Name: Hepatocyte nuclear factor 3-gamma  
Size: 350 amino acids; 37140 Da
Subunit: Interacts with FOXA2
Developmental stage: Detected in prenatal liver nuclear extracts (12.4-27 weeks estimated gestational age). Not
detected in postnatal liver samples
1 PDB 3D structure from and Proteopedia for FOXA3:
1VTN (3D)    
Secondary accessions: A9LYI5 Q53F16 Q9UMW9

Explore the universe of human proteins at neXtProt for FOXA3: NX_P55318

Explore proteomics data for FOXA3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FOXA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004488.2  
    ENSEMBL proteins: 
     ENSP00000470816   ENSP00000304004  
    Reactome Protein details: P55318

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FOX: Forkhead boxes

    5 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR018533 Forkhead_box_C
     IPR018122 TF_fork_head_CS
     IPR013638 Fork-head_N
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry P55318

    ProtoNet protein and cluster: P55318

    1 Blocks protein domain: IPB013638 Fork-head N-terminal

    UniProtKB/Swiss-Prot: FOXA3_HUMAN, P55318
    Similarity: Contains 1 fork-head DNA-binding domain


    FOXA3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXA3_HUMAN, P55318
    Function: Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for
    other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at
    target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a
    number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting
    regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the
    G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to
    the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific
    transcription. May be involved in regulation of spermatogenesis

         Gene Ontology (GO): 9 molecular function terms (see first 5):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9369482
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IBA--
    GO:0008134transcription factor binding IBA--
    GO:0008301DNA binding, bending IBA--
    GO:0019904protein domain specific binding IEA--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0044212transcription regulatory region DNA binding IMP12695546
         
    FOXA3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FOXA3:
     Increased circadian period len  Increased homologous recombina 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Foxa3):
     normal 

    FOXA3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FOXA3
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    miRNA
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    miRTarBase miRNAs that target FOXA3:
    hsa-mir-335-5p (MIRT017722)

    Block miRNA regulation of human, mouse, rat FOXA3 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate FOXA3:
    hsa-miR-3926 hsa-miR-4286 hsa-miR-222* hsa-miR-936 hsa-miR-575 hsa-miR-3919 hsa-miR-548s
    SwitchGear 3'UTR luciferase reporter plasmidFOXA3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FOXA3

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    Sino Biological Human cDNA Clone for FOXA3
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FOXA3_HUMAN, P55318: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IBA--

    FOXA3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FOXA3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of beta-cell development
    Regulation of beta-cell development0.64
    Maturity onset diabetes of the young0.61
    Regulation of gene expression in beta cells0.64
    2FOXA1 transcription factor network
    FOXA1 transcription factor network
    FOXA transcription factor networks0.00
    3L1CAM interactions
    Developmental Biology0.63
    4FOXA2 and FOXA3 transcription factor networks
    FOXA2 and FOXA3 transcription factor networks

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for FOXA3
        FOXA1 transcription factor network
    FOXA2 and FOXA3 transcription factor networks
    FOXA transcription factor networks


    1 Reactome Pathway for FOXA3
        Regulation of gene expression in beta cells


    1 Kegg Pathway  (Kegg details for FOXA3):
        Maturity onset diabetes of the young


    FOXA3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FOXA3
    Interactions:

        Search GeneGlobe Interaction Network for FOXA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for FOXA3 (P553183 ENSP000003040044) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALX4Q9H1613, ENSP000003327444I2D: score=1 STRING: ENSP00000332744
    HMGB1P094293, ENSP000003430404I2D: score=1 STRING: ENSP00000343040
    TLE1Q047243, ENSP000003656824I2D: score=1 STRING: ENSP00000365682
    TLE2Q047253, ENSP000002629534I2D: score=1 STRING: ENSP00000262953
    AFPENSP000002263594STRING: ENSP00000226359
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IBA--
    GO:0001678cellular glucose homeostasis TAS9369482
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006366transcription from RNA polymerase II promoter IBA--

    FOXA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FOXA3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FOXA3 gene: 
    NM_004497.2  

    Unigene Cluster for FOXA3:

    Forkhead box A3
    Hs.36137  [show with all ESTs]
    Unigene Representative Sequence: NM_004497
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000594297 ENST00000302177(uc002pdr.3)
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate FOXA3:
    hsa-miR-3926 hsa-miR-4286 hsa-miR-222* hsa-miR-936 hsa-miR-575 hsa-miR-3919 hsa-miR-548s
    SwitchGear 3'UTR luciferase reporter plasmidFOXA3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FOXA3
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat FOXA3
      QuantiFast Probe-based Assays in human, mouse, rat FOXA3

    Additional mRNA sequence: 

    AK223473.1 BC016024.1 BT006720.1 L12141.1 

    2 DOTS entries:

    DT.108893  DT.91734279 

    Selected AceView cDNA sequences (see all 41):

    BC016024 BQ083358 AI765153 BT006720 BQ008998 BX117799 NM_004497 AA468705 
    BQ082743 BM853521 CK903678 BM823797 AW582880 CK903679 BM824196 AV697549 
    AA602377 BM766874 BI963714 AI310431 AI991177 BM826786 BM796739 AI867382 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FOXA3 expression in normal human tissues (normalized intensities)      FOXA3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTTGGGTAG
    FOXA3 Expression
    About this image


    FOXA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Endoderm (Gastrulation Derivatives)    fully expand to see all 3 entries
             Definitive Endoderm Cells Definitive Endoderm
             Definitive endoderm like cells
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 6 entries
             Hepatic Endoderm Cells Ventral Foregut Endoderm
     
     Liver (Hepatobiliary System)    fully expand to see all 4 entries
             Mature Hepatocytes Liver Lobule
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Primitive Streak (Early Embryonic Tissues)
             Endoderm Progenitor Cells Anterior Primitive Streak
    FOXA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FOXA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.36137

    UniProtKB/Swiss-Prot: FOXA3_HUMAN, P55318
    Tissue specificity: Expressed in erythroleukemia and hepatoma cell lines and in liver and pancreas. Not expressed
    in any other cell lines or tissues examined

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FOXA3 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Foxa31 , 5 forkhead box A31, 5 81.95(n)1
    83.95(a)1
      7 (9.46 cM)5
    153771  NM_008260.21  NP_032286.11 
     190132825 
    lizard
    (Anolis carolinensis)
    Reptilia FOXA36
    forkhead box A3
    48(a)
    1 ↔ 1
    GL344028.1(14068-49153)
    zebrafish
    (Danio rerio)
    Actinopterygii foxa32 forkhead box A3 78.8(n)   30559  AF052245.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fkh6
    fork head
    28(a)
    1 → many
    3R(24406805-24410834)


    ENSEMBL Gene Tree for FOXA3 (if available)
    TreeFam Gene Tree for FOXA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FOXA3 gene
    FOXA22  FOXD4L12  FOXC22  FOXI22  FOXB12  FOXE32  FOXC12  FOXD4L22  
    FOXD4L32  FOXD4L52  FOXD12  FOXD32  FOXD4L42  FOXL12  FOXA12  FOXE12  
    FOXB22  FOXI12  FOXD4L62  FOXS12  FOXD22  FOXL22  FOXD42  
    9 SIMAP similar genes for FOXA3 using alignment to 2 protein entries:     FOXA3_HUMAN (see all proteins):
    FOXB1    FOXB2    FOXD1    FOXS1    FOXD2    FOXC1
    FOXE1    FOXA2    FOXC2

    FOXA3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FOXA3 (see all 203)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1386643741,2
    --46368660(+) GACAGA/TCAGAA 1 -- int10--------
    rs573349051,2
    C,F--46368757(+) GTTGTT/GGGGGC 1 -- int15Minor allele frequency- G:0.11NS WA NA EA 448
    rs575723011,2
    C,F--46368794(+) TTATGG/AGGGTC 1 -- int13Minor allele frequency- A:0.02NS WA 210
    rs1895792051,2
    --46368837(+) TGTGGA/GCTTGA 1 -- int10--------
    rs81126541,2
    C,F--46368977(+) CCTTCA/CGGGCT 1 -- int110Minor allele frequency- C:0.22NS NA WA EA 460
    rs1818383201,2
    --46369176(+) GTGATC/TCCAGC 1 -- int10--------
    rs48038671,2
    C,F,H--46369300(+) TCTAGA/G/TCAGGA 1 -- int112NS EA NA WA 1364
    rs1860235601,2
    --46369392(+) AAAGCA/CGGCAC 1 -- int10--------
    rs1996401301,2
    --46369505(+) TCTTT-/AAAAAA 1 -- int10--------
    rs760694091,2
    F--46369514(+) AAAAAA/TTTTTT 1 -- int11Minor allele frequency- T:0.09WA 118

    HapMap Linkage Disequilibrium report for FOXA3 (46367247 - 46377055 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FOXA3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv523029CNV Loss19592680
    nsv912172CNV Loss21882294
    nsv510770CNV Loss20534489
    dgv3956n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): FOXA3
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FOXA3
    DNA2.0 Custom Variant and Variant Library Synthesis for FOXA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602295    OMIM disorders: --

    10 diseases for FOXA3:    About MalaCards
    pharyngitis    maturity-onset diabetes of the young    bronchiolitis    tonsillitis
    endotheliitis    cerebritis    neuronitis    thyroiditis
    hepatitis    prostatitis


    FOXA3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FOXA3
    Human Genome Epidemiology (HuGE) Navigator: FOXA3 (1 document)

    Export disorders for FOXA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FOXA3 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with FOXA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq. (PubMed id 19919681)1, 2, 9 Motallebipour M.... Wadelius C. (Genome Biol. 2009)
    2. Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma. (PubMed id 12695546)1, 2, 9 Rodriguez-Antona C.... Castell J.V. (Mol. Pharmacol. 2003)
    3. Genetic predictors of interindividual variability in hepatic CYP3A4 expression. (PubMed id 19934400)1, 4 Lamba V....Schuetz E.G. (J. Pharmacol. Exp. Ther. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis. (PubMed id 10899756)1, 2 Navas M.A....Stoffel M. (Hum. Hered. 2000)
    6. The role of HNF1alpha, HNF3gamma, and cyclic AMP in glucose-6- phosphatase gene activation. (PubMed id 9369482)1, 2 Lin B.... Chou J.Y. (Biochemistry 1997)
    7. Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4. (PubMed id 9119385)1, 3 Mincheva A....Kaestner K.H. (Genomics 1997)
    8. Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. (PubMed id 8332212)1, 2 Clark K.L.... Burley S.K. (Nature 1993)
    9. Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells. (PubMed id 8499623)1, 2 Hromas R.... Klemsz M. (Blood 1993)
    10. The winged helix transcription factor Foxa3 regulates adipocyte differentiation and depot-selective fat tissue expansion. (PubMed id 23798556)1 Xu L....Mueller E. (Mol. Cell. Biol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3171 HGNC: 5023 AceView: FOXA3 Ensembl:ENSG00000170608 euGenes: HUgn3171
    ECgene: FOXA3 Kegg: 3171 H-InvDB: FOXA3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FOXA3 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Hepatocyte_nuclear_factors
    SeattleSNPshttp://pga.gs.washington.edu/data/foxa3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FOXA3 gene:
    Search GeneIP for patents involving FOXA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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