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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FOXA2 Gene

protein-coding   GIFtS: 62
GCID: GC20M022561

forkhead box A2

(Previous names: hepatocyte nuclear factor 3, beta )
(Previous symbol: HNF3B)
 Explore 27 diseases affiliated with
FOXA2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FOXA2    

Aliases
for FOXA2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Forkhead Box A21 2     HNF-3B2 3
HNF3B1 2 3 5     TCF-3B2 3
Hepatocyte Nuclear Factor 3, Beta1 2     TCF3B2 3
Forkhead Box Protein A22 3     Hepatic Nuclear Factor-3-Beta2
Transcription Factor 3B2 3     Hepatocyte Nuclear Factor 3-Beta2
HNF-3-Beta1     

External Ids:    HGNC: 50221   Entrez Gene: 31702   Ensembl: ENSG000001257987   OMIM: 6002885   UniProtKB: Q9Y2613   

Export aliases for FOXA2 gene to outside databases

Previous GC identifers: GC20M022550 GC20M022556 GC20M022509 GC20M022523


Summaries
for FOXA2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FOXA2:
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are
transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with
chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the
pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript
variants encoding different isoforms have been identified for this gene. (provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: FOXA2_HUMAN, Q9Y261
Function: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene
expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor
opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby
replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence
5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation.
Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1
and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a
number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting
regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for
glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to
fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation

Gene Wiki entry for FOXA2


Genomic Views
for FOXA2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FOXA2 gene promoter:
         S8   HFH-1   AP-2alpha   ATF   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FOXA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FOXA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOXA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11   Ensembl cytogenetic band:  20p11.21   HGNC cytogenetic band: 20p11

FOXA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOXA2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M022561:  view genomic region     (about GC identifiers)

Start:
 22,561,642 bp from pter      End:
 22,566,101 bp from pter
Size:
 4,460 bases      Orientation:
 minus strand

Proteins
for FOXA2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FOXA2_HUMAN, Q9Y261 (See protein sequence)
Recommended Name: Hepatocyte nuclear factor 3-beta  
Size: 457 amino acids; 48306 Da
Subunit: Binds DNA as a monomer. Binds TLE1 (By similarity). Interacts with FOXA1 and FOXA3. Interacts with PRKDC
Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner;
in response to insulin signaling via AKT1 is exported from the nucleus
Sequence caution: Sequence=AAH11780.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q8WUW4 Q96DF7
Alternative splicing: 2 isoforms:  Q9Y261-1   Q9Y261-2   

Explore the universe of human proteins at neXtProt for FOXA2: NX_Q9Y261

Post-translational modifications:

  • Phosphorylation on Thr-156 abolishes binding to target promoters and subsequent transcription activation upon insulin
    • stimulation (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y261

    • FOXA2 Protein expression data from MOPED and PaxDb:    About this image 
    FOXA2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_068556.2  NP_710141.1  

    ENSEMBL proteins: 
     ENSP00000366319   ENSP00000400341   ENSP00000315955  

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    Novus Biologicals FOXA2 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FOXA2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex IBA--
    GO:0005737cytoplasm IEA--
    GO:0044464cell part ----

    FOXA2 for ontologies           About GeneDecksing



    FOXA2 Antibody Products: 
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    Uscn ELISAs and CLIAs for FOXA2

    Protein Domains /
    Families
    for FOXA2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FOXA2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR018533 Forkhead_box_C
     IPR018122 TF_fork_head_CS
     IPR013638 Fork-head_N
     IPR001766 TF_fork_head

    Graphical View of Domain Structure for InterPro Entry Q9Y261

    ProtoNet protein and cluster: Q9Y261

    1 Blocks protein family: IPB013638 Fork-head N-terminal

    UniProtKB/Swiss-Prot: FOXA2_HUMAN, Q9Y261
    Similarity: Contains 1 fork-head DNA-binding domain


    Function
    for FOXA2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOXA2_HUMAN, Q9Y261
    Function: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene
    expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor
    opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby
    replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence
    5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation.
    Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1
    and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a
    number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting
    regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for
    glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to
    fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation

         Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA12642491
    GO:0003677DNA binding IDA9931457
    GO:0003690double-stranded DNA binding IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA12124776
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IBA--
         
    FOXA2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for FOXA2:
     Decreased nuclei size in G2M  Increased HPV18 LCR reporter a  Synthetic lethal with Ras 

         15/22 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Foxa2) (see all 22):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 

    FOXA2 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Foxa2tm1Jrt for FOXA2
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FOXA2 

    miRNA
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    hsa-miR-631 hsa-miR-200a hsa-miR-3661 hsa-miR-1205 hsa-miR-764 hsa-miR-3167 hsa-miR-141 hsa-miR-548a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: FOXA2 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: FOXA2
    OriGene siRNA: FOXA2
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    Sirion Biotech Custom design and validation of potent shRNA sequences against FOXA2 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of FOXA2 
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    Clone
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    In Situ Assay
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    Pathways & Interactions
    for FOXA2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glucose / Energy Metabolism
    		Glucose / Energy Metabolism1.00
    2PI3K / Akt Signaling
    		PI3K / Akt Signaling1.00
    3Heart Development
    		Heart Development1.00
    4FOXA1 transcription factor network
    		FOXA1 transcription factor network1.00
    5Hedgehog signaling events mediated by Gli proteins
    		Hedgehog signaling events mediated by Gli proteins1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for FOXA2
        Selected targets of C/EBPalpha

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for FOXA2
        MODY (Maturity-Onset Diabetes of Young)

    2 Cell Signaling Technology (CST) Pathways for FOXA2
        PI3K / Akt Signaling
    Glucose / Energy Metabolism

    5 BioSystems Pathways for FOXA2 
        Heart Development
    Hedgehog signaling events mediated by Gli proteins
    FOXA2 and FOXA3 transcription factor networks
    FOXA1 transcription factor network
    FOXA transcription factor networks


    1         Kegg Pathway  (Kegg details for FOXA2):
        Maturity onset diabetes of the young


    FOXA2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FOXA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/51 Interacting proteins for FOXA2 (Q9Y2612, 3 ENSP000003159554) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EN2P196223, ENSP000002973754I2D: score=2 STRING: ENSP00000297375
    GSCP569153, ENSP000002385584I2D: score=2 STRING: ENSP00000238558
    HOXA5P207193, ENSP000002227264I2D: score=2 STRING: ENSP00000222726
    ONECUT1Q9UBC03, ENSP000003026304I2D: score=2 STRING: ENSP00000302630
    OTX2P322433, ENSP000003438194I2D: score=2 STRING: ENSP00000343819
    About this table

    Gene Ontology (GO): 5/49 biological process terms (GO ID links to tree view) (see all 49):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000432positive regulation of transcription from RNA polymerase II promoter by glucose ISS--
    GO:0000433negative regulation of transcription from RNA polymerase II promoter by glucose ISS--
    GO:0001701in utero embryonic development IBA--
    GO:0001705ectoderm formation IBA--
    GO:0001708cell fate specification ----

    FOXA2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FOXA2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FOXA2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FOXA2
    5 Novoseek chemical compound relationships for FOXA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 24.1 14 11875061 (4), 12509444 (2), 17462994 (1), 17327429 (1) (see all 7)
    glycogen 19.8 2 12509444 (1)
    katp 19.1 2 17462994 (1), 11445544 (1)
    c-peptide 18 1 16186387 (1)
    fatty acid 0 3 18360697 (2), 15949766 (1)

    Search CenterWatch for drugs/clinical trials and news about FOXA2 

    Transcripts
    for FOXA2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FOXA2 gene (2 alternative transcripts): 
    NM_021784.4  NM_153675.2  

    Unigene Cluster for FOXA2:

    Forkhead box A2
    Hs.155651  [show with all ESTs]
    Unigene Representative Sequence: NM_021784
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377115(uc002wsn.3) ENST00000419308(uc002wsm.3) ENST00000319993


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    hsa-miR-631 hsa-miR-200a hsa-miR-3661 hsa-miR-1205 hsa-miR-764 hsa-miR-3167 hsa-miR-141 hsa-miR-548a-3p
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB028021.1 AK301611.1 BC006545.2 BC011780.2 BC019288.1 

    2 DOTS entries:

    DT.100743798  DT.423625 

    24/78 AceView cDNA sequences (see all 78):

    AA469087 BM127545 AA133553 BM141833 AW246544 AA515421 AA932551 NM_021784 
    BE793761 BE792651 NM_153675 CA841864 BE791498 AI682236 BC019288 AI703350 
    BE614744 AW250883 AB028021 AI336388 BE222068 BE266755 AI342818 BC006545 

    GeneLoc Exon Structure


    Expression
    for FOXA2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FOXA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGTTTTAAC
    FOXA2 Expression
    About this image

    FOXA2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    10/50 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 50) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EndodermDefinitive EndodermDefinitive Endoderm CellsEarly Embryo, Endoderm
    Neural TubeDiencephalic Ventricular ZoneMeso-diencephalic Dopaminergic Precursor CellsDopaminergic neurons
    Neural TubeMesencephalic Ventricular ZoneMeso-diencephalic Dopaminergic Precursor CellsDopaminergic neurons
    PancreasDorsal Pancreatic BudAlpha Progenitor CellsPancreas
    PancreasVentral Pancreatic BudAlpha Progenitor CellsPancreas
    Primitive StreakAnterior Primitive StreakAnterior Primitive Streak CellsEarly Embryo
    Primitive StreakAnterior Primitive StreakEndoderm Progenitor CellsEarly Embryo
    Primitive StreakNotochordNotochord CellsCartilage
    Primitive StreakPrimitive NodePrimitive Node CellsEarly Embryo
    Spinal CordSpinal Floor PlateFloor Plate Cells Neural Ectoderm
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/45 LifeMap Cells (see all 45) 
    NameCategory
    Extra-embryonic endoderm cells (Fetal Stem / Progenitor Cell)Extraembryonic Tissues
    Otx2+Corin+ cells (Derivation of functi...)
    Midbrain neural progenitor-like cells (Differentiation of h...)
    Ventral midbrain dopaminergic-like neurons (Differentiation of h...)
    N2/LSB/S/F8-induced cells (Generation of midbra...)
    Midbrain dopaminergic-like neurons (Generation of midbra...)
    N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)
    Mesoderm-like cells (Direct differentiati...)Mesoderm
    Definitive endoderm-like cells (Generation and expan...)
    Mesendoderm embryoid bodies (Mouse embryonic stem...)

    See FOXA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FOXA2

    SOURCE GeneReport for Unigene cluster: Hs.155651
        SABiosciences Expression via Pathway-Focused PCR Arrays including FOXA2 (see all 6): 
              Stem Cell Transcription Factors in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Transcription Factors in human mouse rat
              Fatty Liver in human mouse rat

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    Orthologs
    for FOXA2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FOXA2 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FOXA21 forkhead box A2 81.83(n)
    81.44(a)    		   395539  NM_204770.1  NP_990101.1 
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia AY260736.12   -- 80.13(n)    AY260736.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii NM_130949.12   -- 80.46(n)   30126  NM_130949.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta fkh1 fork head 56.7(n)
    48.49(a)    		   43383  NM_001170291.1  NP_001163762.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea pha-46
    		 Defective pharyngeal development protein 4
    		 19(a)
    		 1 → many
    		 V(20752905-20760272)


    ENSEMBL Gene Tree for FOXA2 (if available)
    TreeFam Gene Tree for FOXA2 (if available) 

    Paralogs
    for FOXA2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FOXA2 gene
    FOXF12  FOXD4L12  FOXF22  FOXC22  FOXB12  FOXI22  FOXE32  FOXC12  
    FOXD4L22  FOXQ12  FOXD4L32  FOXA32  FOXD12  FOXD32  FOXD4L52  FOXD4L42  
    FOXE12  FOXL12  FOXA12  FOXB22  FOXI12  FOXD4L62  FOXS12  FOXL22  
    FOXD22  FOXD42  
    9 SIMAP similar genes for FOXA2 using alignment to 2 protein entries:     FOXA2_HUMAN (see all proteins):
    FOXA1    FOXB1    FOXC1    FOXE1    FOXL2    FOXB2
    FOXS1    FOXA3    FOXE3

    FOXA2 for paralogs           About GeneDecksing



    Genomic Variants
    for FOXA2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/142 NCBI SNPs in FOXA2 are shown (see all 142)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1163513631,2
    		F--22561159(+) ATCCAG/CGCTCA 3 -- us2k1 ds50011Minor allele frequency- C:0.02WA 118
    rs1861463931,2
    		--22561177(+) GAAGGC/GAGGCC 3 -- ds5001 us2k10--------
    rs1908624581,2
    		--22561193(+) TCAGAA/CGTACA 3 -- us2k1 ds50010--------
    rs1390319661,2
    		--22561264(+) CACAAC/TAACAG 3 -- us2k1 ds50010--------
    rs1833978041,2
    		--22561267(+) AACAAC/TAGGGC 3 -- ds5001 us2k10--------
    rs1872897591,2
    		--22561363(+) TCCTGA/GGATCT 2 -- ds50010--------
    rs60482061,2
    		C,F,A,H--22561382(+) CATTGT/CGTGTA 2 -- ds500122Minor allele frequency- C:0.22NS EA NA WA CSA 2417
    rs12039081,2
    		C,F--22561397(+) TAACCC/ACCAAA 2 -- ds50014Minor allele frequency- A:0.09NS CSA WA 193
    rs12039091,2
    		C,F,H--22561479(+) TACTGG/TTATCT 2 -- ds500112Minor allele frequency- T:0.03NS EA NA WA 1282
    rs1903763691,2
    		--22561492(+) AAATTC/TGAAGT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for FOXA2 (22561642 - 22566101 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FOXA2: --
    Human Gene Mutation Database (HGMD): FOXA2

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for FOXA2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FOXA2 for disorders           About GeneDecksing

    OMIM gene information: 600288    OMIM disorders: --

    20/27 diseases for FOXA2 (see all 27):    About MalaCards
    maturity-onset diabetes of the young    meckel's diverticulum    hepatitis    hyperinsulinemic hypoglycemia
    insulin resistance    fatty liver disease    alagille syndrome    hypoglycemia
    liver disease    dwarfism    diabetes mellitus    hepatitis c
    hepatitis b    colon carcinoma    thyroid carcinoma    hepatocellular carcinoma
    pharyngitis    pancreatic cancer    thyroiditis    lung cancer

    4 Novoseek disease relationships for FOXA2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    niddm 22.9 6 10868949 (1), 11043867 (1), 10868948 (1)
    insulin resistance 0 1 15949766 (1)
    tumors 0 3 18593902 (1), 16001449 (1), 15205324 (1)
    obesity 0 1 15949766 (1)

    Genetic Association Database (GAD): FOXA2
    Human Genome Epidemiology (HuGE) Navigator: FOXA2 (11 documents)

    Export disorders for FOXA2 gene to outside databases

    Publications
    for FOXA2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FOXA2 gene, integrated from 9 sources (see all 147):
    (articles sorted by number of sources associating them with FOXA2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release. (PubMed id 11875061)1, 3, 9 Wang H....Wollheim C.B. (2002)
    2. Beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the hepatocyte nuclear factor-3beta gene (HNF3B) in Japanese patients with maturity-onset diabetes of the young. (PubMed id 10868948)1, 4, 9 Hinokio Y....Bell G.I. (2000)
    3. Insulin regulates the activity of forkhead transcription factor Hnf- 3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization. (PubMed id 14500912)1, 2, 9 Wolfrum C.... Stoffel M. (2003)
    4. A hepatocyte nuclear factor-3 site in the fibrinogen beta promoter is important for interleukin 6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism. (PubMed id 15737987)1, 2 Verschuur M.... Vos H.L. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    7. Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3 beta and mutation screening in Japanese subjects with maturity-onset diabetes of the young. (PubMed id 10672453)1, 2 Yamada S.... Takeda J. (2000)
    8. The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis. (PubMed id 10899756)1, 2 Navas M.A....Stoffel M. (2000)
    9. Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4. (PubMed id 9119385)1, 3 Mincheva A....Kaestner K.H. (1997)
    10. Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding. (PubMed id 12509444)1, 9 Rausa F.M....Costa R.H. (2003)

    External Searches for FOXA2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FOXA2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3170 HGNC: 5022 AceView: FOXA2 Ensembl:ENSG00000125798 euGenes: HUgn3170
    ECgene: FOXA2 Kegg: 3170 H-InvDB: FOXA2

    Other Databases showing FOXA2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FOXA2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FOXA2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Hepatocyte_nuclear_factors

    Intellectual Property
    for FOXA2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FOXA2 gene:
    Search GeneIP for patents involving FOXA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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