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Aliases & Descriptions for FOSL2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ23306 1, 2 | | FRA2 1, 2, 3 |
| | | Descriptions |
|---|
| FOS-like antigen 2 2 |
|
| | Search outside databases for aliases for FOSL2 genePrevious GC identifers: GC02P028537 GC02P028708 GC02P028590 |
Summaries for FOSL2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for FOSL2: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq] Gene Wiki entry for FOSL2 |
Genomic Location for FOSL2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the FOSL2 gene 
Entrez Gene cytogenetic band: 2p23.3 Ensembl cytogenetic band: 2p23.2 HGNC cytogenetic band: 2p23.3FOSL2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P028527:
(about GC identifiers)
Start:
|
28,469,173 bp from pter |
End:
|
28,493,683 bp from pter |
Size:
|
24,511 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000002.10 NT_022184.14
| Proteins for FOSL2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: FOSL2_HUMAN, P15408 (See
protein sequence)Recommended Name: Fos-related antigen 2 Size: 326 amino acids; 35193 Da
Subunit: Heterodimer (By similarity)
Subcellular location: NucleusPost-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005244.1
ENSEMBL proteins: ENSP00000368939 ENSP00000264716
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: FOSL2 
1 Gene Ontology (GO) cellular component term (links to tree view): About this table
Antibodies for FOSL2: Assays for FOSL2: | Protein
Domains/ Families for FOSL2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P15408
ProtoNet protein and cluster: P15408 2 Blocks protein families: IPB000837 Fos transforming protein signature IPB011616 bZIP transcription factor
UniProtKB/Swiss-Prot: FOSL2_HUMAN, P15408Similarity: Belongs to the bZIP family. Fos subfamilySimilarity: Contains 1 bZIP domain | Gene Function for FOSL2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005253
Applied Biosystems Silencer® siRNAs for FOSL2
Sigma-Aldrich siRNA for FOSL2  Sigma-Aldrich shRNA Panels and shRNA for FOSL2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005253                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005253                                  untagged cDNA clone in CMV expression vector: NM_005253 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005253
Genatlas biochemistry entry for FOSL2:fos-related antigen 24 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Fosl2):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for FOSL2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for FOSL2 
5/20 Interacting proteins for FOSL2 (ENSP000002647163) via UniProtKB, MINT, and/or STRING (see all 20
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for FOSL2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for FOSL2 3 Novoseek chemical compound relationships for FOSL2 gene
About this table
|
Transcripts for FOSL2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005253
Sigma-Aldrich siRNA for FOSL2  Sigma-Aldrich shRNA Panels and shRNA for FOSL2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005253 REFSEQ mRNAs for FOSL2 gene: NM_005253.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005253               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005253                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005253                                  untagged cDNA clone in CMV expression vector: NM_005253  Additional cDNA sequence: AK026959.1 AK055579.1 AK302622.1 AK315415.1 BC008899.2 BC022791.1 BC085197.1 BX647822.1 CR542262.1 X16706.1 11 DOTS entries: DT.442351 DT.95279865 DT.95372886 DT.120945985 DT.91653540 DT.99929017 DT.91763925 DT.120945947 DT.120945946 DT.92006784 DT.95291406 24/303 AceView cDNA sequences (see all 303
):CA942758 BG740183 CB124542 BC022791 BQ278993 CA448783 AA382007 H67523 BU180550 BX280649 BF515028 AI982980 BU739117 NM_005253 AI083545 BG120066 AI246689 AI088306 AI560860 BU153253 BQ718247 AW517421 AW001583 BX647822
highest scoring ESTs for FOSL2:AI982980 X16706 AA101616 AA366723 AA382007 AA574332 AA594624 AA661745 AI083545 AI088306 Unigene Cluster for FOSL2: FOS-like antigen 2 Hs.220971 [show with all ESTs]Unigene Representative Sequence: BX647822
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for FOSL2
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | |
| SP1: | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | - |   | - |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for FOSL2
2 Ensembl transcripts including schematic representations: ENST00000379619
ENST00000264716
|
Expression for FOSL2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| FOSL2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for FOSL2
1 / 2 / 3 19 probe-sets matching FOSL2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.220971
Expression variation in blood from EXPOLDB for FOSL2 |
Orthologs for FOSL2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for FOSL2 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for FOSL2
ENSEMBL Gene Tree for FOSL2 | Paralogs for FOSL2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for FOSL2 gene
- FOSL12 FOSB2 FOS2
|
SNPs/Variants for FOSL2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for FOSL2 (up to first 250kb)
|
Disorders & Mutations for FOSL2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 601575
6 Novoseek disease relationships for FOSL2 gene
About this table
Tumor Gene Database: FOSL2
|
Medical News for FOSL2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for FOSL2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/127 PubMed articles for FOSL2 gene (see all 127
):- Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. (PubMed id 2107490)1, 3, 4 Matsui M.... Ishizaki R. (1990)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)3, 4 Beausoleil S.A....Gygi S.P. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2) to chromosome 2p22-p23. (PubMed id 8954781)1, 3 Molven A....Berger R. (1996)
- Role of Fra-2 in breast cancer: influence on tumor cell invasion and motility. (PubMed id 17393299)1, 3 Milde-Langosch K....Loning T. (2008)
- Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1. (PubMed id 18641127)1, 3 Eferl R....Wagner E.F. (2008)
- Aberrant expression of Fra-2 promotes CCR4 expression and cell proliferation in adult T-cell leukemia. (PubMed id 18071306)1, 3 Nakayama T....Yoshie O. (2008)
- Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators. (PubMed id 11570575)1, 3 Bamberger A.M....Loning T. (2001)
- Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma. (PubMed id 19321746)3 Mathas S....DAPrken B. (2009)
|
Search for FOSL2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing FOSL2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing FOSL2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FOSL2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for FOSL2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for FOSL2:

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