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Aliases for FOSL2 Gene

Aliases for FOSL2 Gene

  • FOS-Like Antigen 2 2 3
  • FRA-2 3 4
  • FRA2 3 4

External Ids for FOSL2 Gene

Previous GeneCards Identifiers for FOSL2 Gene

  • GC02P028537
  • GC02P028708
  • GC02P028590
  • GC02P028527
  • GC02P028615
  • GC02P028356

Summaries for FOSL2 Gene

Entrez Gene Summary for FOSL2 Gene

  • The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]

GeneCards Summary for FOSL2 Gene

FOSL2 (FOS-Like Antigen 2) is a Protein Coding gene. Among its related pathways are ERK Signaling and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is FOSL1.

UniProtKB/Swiss-Prot for FOSL2 Gene

  • Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.

Gene Wiki entry for FOSL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOSL2 Gene

Genomics for FOSL2 Gene

Regulatory Elements for FOSL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FOSL2 Gene

Chromosome:
2
Start:
28,392,448 bp from pter
End:
28,417,312 bp from pter
Size:
24,865 bases
Orientation:
Plus strand

Genomic View for FOSL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOSL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOSL2 Gene

Proteins for FOSL2 Gene

  • Protein details for FOSL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15408-FOSL2_HUMAN
    Recommended name:
    Fos-related antigen 2
    Protein Accession:
    P15408
    Secondary Accessions:
    • B2RD58
    • B3KP27
    • B4DYV4
    • Q6FG46

    Protein attributes for FOSL2 Gene

    Size:
    326 amino acids
    Molecular mass:
    35193 Da
    Quaternary structure:
    • Heterodimer.

    Alternative splice isoforms for FOSL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOSL2 Gene

Proteomics data for FOSL2 Gene at MOPED

Post-translational modifications for FOSL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOSL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOSL2 Gene

Domains & Families for FOSL2 Gene

Gene Families for FOSL2 Gene

Protein Domains for FOSL2 Gene

Suggested Antigen Peptide Sequences for FOSL2 Gene

Graphical View of Domain Structure for InterPro Entry

P15408

UniProtKB/Swiss-Prot:

FOSL2_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. Fos subfamily.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. Fos subfamily.
genes like me logo Genes that share domains with FOSL2: view

Function for FOSL2 Gene

Molecular function for FOSL2 Gene

GENATLAS Biochemistry:
fos-related antigen 2
UniProtKB/Swiss-Prot Function:
Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.

Gene Ontology (GO) - Molecular Function for FOSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding --
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding IBA --
GO:0003682 chromatin binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 8954781
genes like me logo Genes that share ontologies with FOSL2: view
genes like me logo Genes that share phenotypes with FOSL2: view

Animal Models for FOSL2 Gene

MGI Knock Outs for FOSL2:

Animal Model Products

miRNA for FOSL2 Gene

miRTarBase miRNAs that target FOSL2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOSL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FOSL2 Gene

Localization for FOSL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOSL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOSL2 Gene COMPARTMENTS Subcellular localization image for FOSL2 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for FOSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8954781
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with FOSL2: view

Pathways & Interactions for FOSL2 Gene

genes like me logo Genes that share pathways with FOSL2: view

Gene Ontology (GO) - Biological Process for FOSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003334 keratinocyte development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 8954781
GO:0008219 cell death TAS 8954781
genes like me logo Genes that share ontologies with FOSL2: view

No data available for SIGNOR curated interactions for FOSL2 Gene

Drugs & Compounds for FOSL2 Gene

(3) Drugs for FOSL2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
estrogen Pharma 0
Calcium Nutra 0
leucine Nutra 93

(2) Additional Compounds for FOSL2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N Acetylcysteine
PD 98,059
genes like me logo Genes that share compounds with FOSL2: view

Transcripts for FOSL2 Gene

Unigene Clusters for FOSL2 Gene

FOS-like antigen 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOSL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOSL2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - - - -

Relevant External Links for FOSL2 Gene

GeneLoc Exon Structure for
FOSL2
ECgene alternative splicing isoforms for
FOSL2

Expression for FOSL2 Gene

mRNA expression in normal human tissues for FOSL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FOSL2 Gene

This gene is overexpressed in Adrenal (64.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FOSL2 Gene



SOURCE GeneReport for Unigene cluster for FOSL2 Gene Hs.220971

genes like me logo Genes that share expression patterns with FOSL2: view

Protein tissue co-expression partners for FOSL2 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FOSL2 Gene

Orthologs for FOSL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOSL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOSL2 35
  • 92.23 (n)
  • 97.24 (a)
FOSL2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOSL2 35
  • 92.72 (n)
  • 98.46 (a)
FOSL2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fosl2 35
  • 89.74 (n)
  • 95.38 (a)
Fosl2 16
Fosl2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOSL2 35
  • 99.59 (n)
  • 100 (a)
FOSL2 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fosl2 35
  • 89.64 (n)
  • 94.77 (a)
oppossum
(Monodelphis domestica)
Mammalia FOSL2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOSL2 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOSL2 35
  • 80.02 (n)
  • 88.2 (a)
FOSL2 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOSL2 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fosl2 35
  • 73.4 (n)
  • 79.17 (a)
African clawed frog
(Xenopus laevis)
Amphibia gene 35
zebrafish
(Danio rerio)
Actinopterygii fosl2 35
  • 67.5 (n)
  • 70.4 (a)
fosl2 36
  • 65 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6126 35
fruit fly
(Drosophila melanogaster)
Insecta kay 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for FOSL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOSL2 Gene

ENSEMBL:
Gene Tree for FOSL2 (if available)
TreeFam:
Gene Tree for FOSL2 (if available)

Paralogs for FOSL2 Gene

Paralogs for FOSL2 Gene

(6) SIMAP similar genes for FOSL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FOSL2: view

Variants for FOSL2 Gene

Sequence variations from dbSNP and Humsavar for FOSL2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7562 -- 28,412,873(+) CCCTT(C/T)CCTCC utr-variant-3-prime
rs931949 -- 28,409,324(+) GCCAG(A/G)GAGAA intron-variant
rs1039823 -- 28,400,292(+) CGTCC(A/G)TAGAG intron-variant
rs2048240 -- 28,417,460(+) ACTTC(C/T)TTCTG downstream-variant-500B
rs2175093 -- 28,416,606(+) GACAT(C/T)TACAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FOSL2 Gene

Variant ID Type Subtype PubMed ID
nsv873763 CNV Loss 21882294
nsv828664 CNV Gain 20364138

Variation tolerance for FOSL2 Gene

Residual Variation Intolerance Score: 16.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOSL2 Gene

HapMap Linkage Disequilibrium report
FOSL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOSL2 Gene

Disorders for FOSL2 Gene

Relevant External Links for FOSL2

Genetic Association Database (GAD)
FOSL2
Human Genome Epidemiology (HuGE) Navigator
FOSL2
Tumor Gene Database (TGDB):
FOSL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOSL2
genes like me logo Genes that share disorders with FOSL2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOSL2 Gene

Publications for FOSL2 Gene

  1. The transcription factor Fra-2 regulates the production of extracellular matrix in systemic sclerosis. (PMID: 20039427) Reich N. … Distler J.H. (Arthritis Rheum. 2010) 23 67
  2. Inhibitory effect of cantharidin on osteoclast differentiation and bone resorption. (PMID: 20361312) Kim M.H. … Kim S.H. (Arch. Pharm. Res. 2010) 23 67
  3. Estrogen receptor alpha, fos-related antigen-2, and c-Jun coordinately regulate human UDP glucuronosyltransferase 2B15 and 2B17 expression in response to 17beta-estradiol in MCF-7 cells. (PMID: 19487245) Hu D.G. … Mackenzie P.I. (Mol. Pharmacol. 2009) 23 67
  4. Inflammation and epithelial alterations in rat prostate: impact of the androgen to oestrogen ratio. (PMID: 19515173) Yatkin E. … Santti R. (Int. J. Androl. 2009) 23 67
  5. Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction. (PMID: 19282289) Rangaswami H. … Pilz R.B. (J. Biol. Chem. 2009) 23 67

Products for FOSL2 Gene

Sources for FOSL2 Gene

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