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FOSL2 Gene

protein-coding   GIFtS: 60

GC02P028527
FOS-like antigen 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ23306 1, 2
FRA2 1, 2, 3
Descriptions
FOS-like antigen 2 2
External Ids
HGNC: 37981
Entrez Gene: 23552
UniProtKB: P154083
Ensembl: ENSG000000754267
Search outside databases for aliases for FOSL2 gene

Previous GC identifers: GC02P028537 GC02P028708 GC02P028590

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for FOSL2:
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine
zipper proteins that can dimerize with proteins of the JUN family, thereby forming the
transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of
cell proliferation, differentiation, and transformation. [provided by RefSeq]

Gene Wiki entry for FOSL2
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the FOSL2 gene  

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.2   HGNC cytogenetic band: 2p23.3

FOSL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P028527:     (about GC identifiers)

Start:
28,469,173 bp from pter
End:
28,493,683 bp from pter
Size:
24,511 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000002.10  NT_022184.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: FOSL2_HUMAN, P15408 (See protein sequence)
Recommended Name: Fos-related antigen 2  
Size: 326 amino acids; 35193 Da
Subunit: Heterodimer (By similarity)
Subcellular location: Nucleus

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_005244.1  

    ENSEMBL proteins: 
    ENSP00000368939 ENSP00000264716 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (FRA2)
    Human Recombinant Proteins from Abnova (FOSL2)
                  OriGene Purified Recombinant Human Protein: FOSL2 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus TAS8954781
    About this table

    Antibodies for FOSL2: 
    Invitrogen Antibodies for FOSL2
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for FOSL2
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (FRA2), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (FOSL2)
    Novus Biologicals Antibodies for FOSL2

    Assays for FOSL2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR004827 TF_bZIP
     IPR000837 Leuzip_Fos
     IPR011616 bZIP_1


       GeneDecks  FOSL2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P15408

    ProtoNet protein and cluster: P15408

    2 Blocks protein families:
    IPB000837 Fos transforming protein signature
    IPB011616 bZIP transcription factor


    UniProtKB/Swiss-Prot: FOSL2_HUMAN, P15408
    Similarity: Belongs to the bZIP family. Fos subfamily
    Similarity: Contains 1 bZIP domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (FOSL2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (FOSL2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005253

                  Applied Biosystems Silencer® siRNAs for FOSL2

                  Sigma-Aldrich siRNA for FOSL2  
                         Sigma-Aldrich shRNA Panels and shRNA for FOSL2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for FOSL2
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005253
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005253
                                     untagged cDNA clone in CMV expression vector: NM_005253 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_005253

    Genatlas biochemistry entry for FOSL2:
    fos-related antigen 2

    4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Fosl2):

    growth/sizelethality-postnatallimbs/digits/tailskeleton

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700 transcription factor activity TAS8954781
    GO:0043565 sequence-specific DNA binding IEA--
    GO:0046983 protein dimerization activity IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    5 Millipore Pathways for FOSL2
     Immune response CD16 signaling in NK cells
     Immune response IL-3 activation and signaling pathway
     Immune response Oncostatin M signaling via MAPK in human cells
     Immune response IL-1 signaling pathway
     Immune response IL-2 activation and signaling pathway

       GeneDecks  FOSL2 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  FOSL2 


    5/20 Interacting proteins for FOSL2 (ENSP000002647163) via UniProtKB, MINT, and/or STRING (see all 20 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP2K1ENSP000003024863STRING (score=.939)
    NFATC1ENSP000003278503STRING (score=.925)
    NGFENSP000003585253STRING (score=.905)
    ABCA1ENSP000003638683STRING (score=.861)
    IL17AENSP000003441923STRING (score=.858)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357 regulation of transcription from RNA polymerase II promoter TAS8954781
    GO:0008219 cell death TAS8954781
    GO:0048146 positive regulation of fibroblast proliferation IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for FOSL2
    3 Novoseek chemical compound relationships for FOSL2 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 20.13 2 7568884 (1), 16829632 (1)
    pd 98,059 16.29 1 10762717 (1)
    calcium 0.00 1 9858557 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (FOSL2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (FOSL2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005253

                  Sigma-Aldrich siRNA for FOSL2  
                         Sigma-Aldrich shRNA Panels and shRNA for FOSL2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_005253  

    REFSEQ mRNAs for FOSL2 gene: 

    NM_005253.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_005253  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005253
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005253
                                     untagged cDNA clone in CMV expression vector: NM_005253 

    Additional cDNA sequence: 

    AK026959.1 AK055579.1 AK302622.1 AK315415.1 BC008899.2 BC022791.1 BC085197.1 BX647822.1 
    CR542262.1 X16706.1 

    11 DOTS entries:

    DT.442351  DT.95279865  DT.95372886  DT.120945985  DT.91653540  DT.99929017  DT.91763925  DT.120945947 
    DT.120945946  DT.92006784  DT.95291406 

    24/303 AceView cDNA sequences (see all 303 ):

    CA942758 BG740183 CB124542 BC022791 BQ278993 CA448783 AA382007 H67523 
    BU180550 BX280649 BF515028 AI982980 BU739117 NM_005253 AI083545 BG120066 
    AI246689 AI088306 AI560860 BU153253 BQ718247 AW517421 AW001583 BX647822 

    highest scoring ESTs for FOSL2:

    AI982980 X16706 AA101616 AA366723 AA382007 AA574332 AA594624 AA661745 AI083545 AI088306 

    Unigene Cluster for FOSL2:

    FOS-like antigen 2
    Hs.220971  [show with all ESTs]
    Unigene Representative Sequence: BX647822


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FOSL2

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:        -     -     -     -                             -                           
    SP2:                    -     -                             -     -                     
    SP3:                    -     -                                                         
    SP4:                                                        -     -                     
    SP5:                                      -     -           -     -                     

    About this scheme

    ECgene alternative splicing isoforms for FOSL2

    2 Ensembl transcripts including schematic representations:
    ENST00000379619  ENST00000264716  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    FOSL2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for FOSL2

    1 / 2 / 3

    19 probe-sets matching FOSL2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    92155_at2, 3 U95-D 1 1.00 1.00 0.61 0.92 AI813661 0.80 1.00 0.91 1

    49229_at2, 3 U95-B 1 1.00 1.00 0.99 1.12 N24480 0.60 1.00 0.82 1
    45565_r_at2, 3 U95-B 1 1.00 1.00 0.81 0.84 AI290237 0.60 1.00 0.82 1
    80379_at2, 3 U95-E 1 1.00 1.00 0.90 0.88 AI982980 1.00 1.00 1.00 1
    47549_at2, 3 U95-B 1 1.00 1.00 0.90 0.96 AI860150 0.80 1.00 0.91 1

    40268_at2, 3 U95-A 1 1.00 1.00 0.55 1.04 X16706 1.00 1.00 1.00 1
    46154_at2, 3 U95-B 2 1.00 0.97 0.91 1.13 AI670862 0.80 1.00 0.91 1

    45564_s_at2, 3 U95-B 2 1.00 0.88 0.90 1.13 AI290237 0.60 1.00 0.82 1
    74986_at2, 3 U95-D 1 0.81 1.00 0.82 0.99 AW006309 0.40 1.00 0.76 1

    218881_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_024530 0.20 1.00 0.72 1

    228188_at2, 3 U133-B 1 1.00 1.00 -- -- AI860150 0.80 1.00 0.91 1

    205409_at2, 3 U133-A 1 1.00 1.00 -- -- NM_005253 0.60 1.00 0.82 1

    218880_at2, 3 U133-A 1 1.00 1.00 -- -- N36408 0.80 1.00 0.91 1

    225262_at2, 3 U133-B 1 1.00 1.00 -- -- AI670862 0.80 1.00 0.91 1

    218881_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    228188_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    205409_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    218880_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    225262_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  FOSL2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.220971

    Expression variation in blood from EXPOLDB for FOSL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for FOSL2 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    FOSL21   -- FOS-like antigen 2 92.72(n)
    98.46(a)
    608412  XM_845624.1  XP_850717.1 
    chimpanzee
    (Pan troglodytes)
    FOSL21   -- FOS-like antigen 2 99.59(n)
    100(a)
    742240  XM_001160962.1  XP_001160962.1 
    cow
    (Bos taurus)
    FOSL21   -- FOS-like antigen 2 92.43(n)
    97.55(a)
    509889  XM_864138.2  XP_869231.1 
    mouse
    (Mus musculus)
    Fosl21, 5 5 (18.10 cM)5
    fos-like antigen 21, 5 89.74(n)1
    95.38(a)1
    142841  NM_008037.31  NP_032063.21 
     AA4746065  AI3233105  (see all 16)
    chicken
    (Gallus gallus)
    FOSL21   -- FOS-like antigen 2 80.23(n)
    88.2(a)
    421416  NM_001045836.1  NP_001039301.1 
    About this table        Species with no ortholog for FOSL2

    ENSEMBL Gene Tree for FOSL2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for FOSL2 gene
    FOSL12  FOSB2  FOS2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/112 NCBI SNPs in FOSL2 are shown (see all 112 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 55)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs75621,2
    A,C,F,H28489244(+) CCCTTT/CCCTCC 1 -- ut31 trp36Minor allele frequency- C:0.47MN EU EA WA 792
    rs22799901,2
    A,C,F,H28490244(+) CTGGAA/GTTGGA 1 -- ut315Minor allele frequency- G:0.32EA EU WA 1908
    rs9252551,2
    A,C,F,H28468298(-) AATAAG/AAGTAA 1 -- ng5112Minor allele frequency- A:0.35NA EA MN EU WA 1250
    --
    rs75897961,2
    A,C,H28490131(+) AGTGCA/GCTCTT 1 -- ut314Minor allele frequency- G:0.00EU EA WA 412
    rs116808601,2
    A,C,F28467808(+) ATAAGG/AACCCT 1 -- ng51 tfbs32Minor allele frequency- A:0.16NA 182
    rs118847251,2
    C,H28488852(+) GAGGGG/AGTCCT 1 -- ut314Minor allele frequency- A:0.00EU EA WA 420
    rs76012411,2
    A,C28489632(+) AGGAAG/TCATGC 1 -- ut310--------
    --
    rs76013571,2
    A,C28489759(+) GAGGCA/GTCCCT 1 -- ut31 ese30--------
    rs76013411,2
    A,H28489697(+) AGGGCG/ATCTCC 1 -- ut31 ese34Minor allele frequency- A:0.00EU EA WA 418
    rs116770021,2
    C28467905(+) TCCGCC/TACAGT 1 -- ng510--------
    About this table

    HapMap Linkage Disequilibrium images for FOSL2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 601575

    6 Novoseek disease relationships for FOSL2 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma 8.16 4 15319566 (1), 15923159 (1), 17393299 (1)
    tumors 7.74 12 17393299 (2), 10502734 (2), 15514944 (1), 11570575 (1) (see all 7)
    breast cancer 0.00 6 17393299 (3), 15319566 (1), 18088579 (1), 17009623 (1)
    adenocarcinoma 0.00 1 12902987 (1)
    nsclc 0.00 2 9662339 (1), 10206277 (1)
    leukemia 0.00 5 8954781 (2)
    About this table

    Tumor Gene Database: FOSL2

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/127 PubMed articles for FOSL2 gene (see all 127 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 2355 HGNC: 3798 AceView: FOSL2 Ensembl:ENSG00000075426 euGenes: HUgn2355
    ECgene: FOSL2 H-InvDB: FOSL2
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for FOSL2 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for FOSL2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for FOSL2-related products

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     Predesigned and custom siRNAs for FOSL2 Antibodies for FOSL2
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for FOSL2 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     shRNA in GFP-retroviral vector
     Search Tocris compounds for FOSL2




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for FOSL2

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