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FOSL2 Gene

protein-coding   GIFtS: 66
GCID: GC02P028615

FOS-Like Antigen 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
FOS-Like Antigen 21 2
FRA-22 3
FRA22 3
Fos-Related Antigen 22

External Ids:    HGNC: 37981   Entrez Gene: 23552   Ensembl: ENSG000000754267   OMIM: 6015755   UniProtKB: P154083   
ORGUL members:         

Export aliases for FOSL2 gene to outside databases

Previous GC identifers: GC02P028537 GC02P028708 GC02P028590 GC02P028527 GC02P028356


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FOSL2 Gene:
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins
that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As
such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and
transformation. (provided by RefSeq, Jul 2008)

GeneCards Summary for FOSL2 Gene:
FOSL2 (FOS-like antigen 2) is a protein-coding gene. Diseases associated with FOSL2 include human t-cell leukemia virus type 1, and adult t-cell leukemia. GO annotations related to this gene include RNA polymerase II regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOSL1.

UniProtKB/Swiss-Prot: FOSL2_HUMAN, P15408
Function: Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription
(By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity)

Gene Wiki entry for FOSL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FOSL2 gene promoter:
         C/EBPbeta   E2F   E2F-1   p53   MyoD   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOSL2 promoter sequence
   Search Chromatin IP Primers for FOSL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOSL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.2   HGNC cytogenetic band: 2p23.3

FOSL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOSL2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P028615:  view genomic region     (about GC identifiers)

Start:
28,615,315 bp from pter      End:
28,640,179 bp from pter
Size:
24,865 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FOSL2_HUMAN, P15408 (See protein sequence)
Recommended Name: Fos-related antigen 2  
Size: 326 amino acids; 35193 Da
Subunit: Heterodimer (By similarity)
Secondary accessions: B2RD58 B3KP27 B4DYV4 Q6FG46
Alternative splicing: 3 isoforms:  P15408-1   P15408-2   P15408-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FOSL2: NX_P15408

Explore proteomics data for FOSL2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FOSL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005244.1  
    ENSEMBL proteins: 
     ENSP00000368939   ENSP00000264716   ENSP00000396497   ENSP00000439303  

    FOSL2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    2 InterPro protein domains:
     IPR004827 bZIP
     IPR000837 Leuzip_Fos

    Graphical View of Domain Structure for InterPro Entry P15408

    ProtoNet protein and cluster: P15408

    2 Blocks protein domains:
    IPB000837 Fos transforming protein signature
    IPB011616 bZIP transcription factor


    UniProtKB/Swiss-Prot: FOSL2_HUMAN, P15408
    Similarity: Belongs to the bZIP family. Fos subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    FOSL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOSL2_HUMAN, P15408
    Function: Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription
    (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity)

         Genatlas biochemistry entry for FOSL2:
    fos-related antigen 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding ----
         
    FOSL2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FOSL2:
     Big cells  Increased HPV18 LCR reporter a 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Fosl2):
     cellular  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  skeleton 

    FOSL2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fosl2tm1Wag for FOSL2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FOSL2
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    miRNA
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    Block miRNA regulation of human, mouse, rat FOSL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FOSL2 (see all 55):
    hsa-miR-579 hsa-miR-4254 hsa-miR-574-3p hsa-miR-25 hsa-miR-486-3p hsa-miR-342-3p hsa-miR-1304 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidFOSL2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FOSL2

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOSL2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOSL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FOSL2_HUMAN, P15408: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    FOSL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FOSL2 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    NOD-like Receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    IL-1 Family Signaling Pathways0.44
    Immune response IL 1 signaling pathway0.42
    2IL-17 Family Signaling Pathways
    IL-17 Family Signaling Pathways0.51
    Mucin expression in CF via IL 6, IL 17 signaling pathways0.48
    3Immune response IL 2 activation and signaling pathway
    Immune response IL 2 activation and signaling pathway0.41
    Immune response IL 3 activation and signaling pathway0.41
    4TCR Signaling (Qiagen)
    ITK and TCR Signaling0.54
    5ERK Signaling
    ILK Signaling0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for FOSL2
        NOD-like Receptor Signaling Pathways
    IL-1 Family Signaling Pathways
    IL-17 Family Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FOSL2 (see all 6)
        iNOS Signaling
    SMAD Signaling Network
    Ceramide Pathway
    ILK Signaling
    ITK and TCR Signaling

    Selected GeneGo (Thomson Reuters) Pathways for FOSL2 (see all 7)
        Mucin expression in CF via TLRs, EGFR signaling pathways
    Immune response IL-3 activation and signaling pathway
    Immune response CD16 signaling in NK cells
    Mucin expression in CF via IL-6, IL-17 signaling pathways
    Immune response IL-2 activation and signaling pathway

    1 BioSystems Pathway for FOSL2
        Corticotropin-releasing hormone


    1 PharmGKB Pathway for FOSL2
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for FOSL2):
        Osteoclast differentiation


    FOSL2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FOSL2
    Interactions:

        GeneGlobe Interaction Network for FOSL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FOSL2 (P154083 ENSP000002647164) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNP054123, ENSP000003602664I2D: score=4 STRING: ENSP00000360266
    JUNBP172753, ENSP000003033154I2D: score=3 STRING: ENSP00000303315
    JUNDP175353, ENSP000002528184I2D: score=3 STRING: ENSP00000252818
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    FOSP011003, ENSP000003062454I2D: score=1 STRING: ENSP00000306245
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS8954781
    GO:0006366transcription from RNA polymerase II promoter IEA--
    GO:0007565female pregnancy IEA--

    FOSL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FOSL2

    5 Novoseek inferred chemical compound relationships for FOSL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 18.4 2 7568884 (1), 16829632 (1)
    pd 98,059 14.1 1 10762717 (1)
    n acetylcysteine 5.86 1 15989974 (1)
    estrogen 4.58 5 18583549 (2), 19487245 (1)
    calcium 0 1 9858557 (1)



    FOSL2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FOSL2 gene: 
    NM_005253.3  

    Unigene Cluster for FOSL2:

    FOS-like antigen 2
    Hs.220971  [show with all ESTs]
    Unigene Representative Sequence: BX647822
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000460736 ENST00000379619(uc010ymi.2 uc021vfg.1) ENST00000264716(uc002rma.3)
    ENST00000436647 ENST00000545753
    miRNA
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    hsa-miR-579 hsa-miR-4254 hsa-miR-574-3p hsa-miR-25 hsa-miR-486-3p hsa-miR-342-3p hsa-miR-1304 hsa-miR-124
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      QuantiTect SYBR Green Assays in human, mouse, rat FOSL2
      QuantiFast Probe-based Assays in human, mouse, rat FOSL2

    Additional mRNA sequence: 

    AK026959.1 AK055579.1 AK302622.1 AK315415.1 BC008899.2 BC022791.1 BC085197.1 BX647822.1 
    CR542262.1 X16706.1 

    10 DOTS entries:

    DT.442351  DT.95279865  DT.95372886  DT.120945985  DT.91653540  DT.91763925  DT.120945947  DT.120945946 
    DT.92006784  DT.95291406 

    Selected AceView cDNA sequences (see all 303):

    AI560860 BM023443 AI083545 BQ672006 BU158245 AK026959 N49170 BM825578 
    AW954833 AU099184 CK904433 BU538259 AW001583 H67523 AA313755 AI982980 
    AI246689 BQ278993 BI856278 BE378591 AA773546 AA036901 BM825620 AI948640 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FOSL2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:        -     -     -     -                             -                           
    SP2:                    -     -                             -     -                     
    SP3:                    -     -                                                         
    SP4:                                                        -     -                     
    SP5:                                      -     -           -     -                     


    ECgene alternative splicing isoforms for FOSL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FOSL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACATTTCATC
    FOSL2 Expression
    About this image


    FOSL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Cells Ureteric Bud
     
     Ovary (Reproductive System)
             Oviduct
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Neural Tube (Nervous System)
             Telencephalon
    FOSL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FOSL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.220971
        Custom PCR Arrays for FOSL2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOSL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FOSL2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fosl21 , 5 fos-like antigen 21, 5 89.74(n)1
    95.38(a)1
      5 (17.33 cM)5
    142841  NM_008037.41  NP_032063.21 
     321364725 
    chicken
    (Gallus gallus)
    Aves FOSL21 FOS-like antigen 2 80.02(n)
    88.2(a)
      421416  NM_001045836.1  NP_001039301.1 
    lizard
    (Anolis carolinensis)
    Reptilia FOSL26
    FOS-like antigen 2
    81(a)
    1 ↔ 1
    2(125823843-125848478)
    African clawed frog
    (Xenopus laevis)
    Amphibia gene2 fos-related antigen-2 77.27(n)    U37374.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fosl21 fos-like antigen 2 67.5(n)
    70.4(a)
      558921  NM_001082998.1  NP_001076467.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta kay6
    kayak
    12(a)
    1 → many
    3R(25592497-25619838)


    ENSEMBL Gene Tree for FOSL2 (if available)
    TreeFam Gene Tree for FOSL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for FOSL2 gene
    FOSL12  FOSB2  FOS2  
    6 SIMAP similar genes for FOSL2 using alignment to 2 protein entries:     FOSL2_HUMAN (see all proteins):
    ATF3    JDP2    BATF    FOS    FOSB    FOSL1

    FOSL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FOSL2 (see all 383)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1831295901,2
    --28619678(+) ACACAA/CACACA 1 -- int10--------
    rs601041091,2
    C--28619704(+) ACACA-/CAAAATT 1 -- int11Minor allele frequency- CA:0.00NA 2
    rs134082041,2
    C,F--28619808(+) CTCAAT/ACATAC 1 -- int13Minor allele frequency- A:0.21CSA WA 122
    rs2005639691,2
    --28620085(+) ATAAA-/AAAT  
            
    AAAAA
    1 -- int10--------
    rs101912821,2
    C,F,A,H--28620088(+) AAAAAA/TAAAAA 1 -- int11Minor allele frequency- T:0.33NA 6
    rs1999358911,2
    --28620088(+) AAAAA-/TAAAAA 1 -- int10--------
    rs353871931,2
    --28620090(+) AAATAA/TAAATA 1 -- int12Minor allele frequency- T:0.25NA 4
    rs2011962591,2
    --28620090(+) AATAA-/TAAATA 1 -- int10--------
    rs101888211,2
    C,F,A,H--28620092(+) ATAAAA/C/TATAAA 1 -- int11NA 6
    rs1483648691,2
    --28620123(+) TTCCTA/GTTTTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for FOSL2 (28615315 - 28640179 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FOSL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv873763CNV Loss21882294
    nsv828664CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FOSL2
    DNA2.0 Custom Variant and Variant Library Synthesis for FOSL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601575    OMIM disorders: --

    Selected diseases for FOSL2 (see all 33):    
    About MalaCards
    human t-cell leukemia virus type 1    adult t-cell leukemia    familial breast cancer    t-cell leukemia
    anaplastic large cell lymphoma    neurofibromatosis    oral cancer    brain injury
    cutaneous t cell lymphoma    pheochromocytoma    pulmonary fibrosis    breast cancer
    astrocytoma    type 1 diabetes    cervical cancer    b-cell lymphomas
    ischemia    cervicitis    inflammatory bowel disease    leukemia


    FOSL2 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for FOSL2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 7.63 6 17393299 (3), 15319566 (1), 18088579 (1), 17009623 (1)
    tumors 6.96 13 17393299 (2), 10502734 (2), 15514944 (1), 11570575 (1) (see all 8)
    carcinoma 6.06 4 15319566 (1), 15923159 (1), 17393299 (1)
    leukemia 0 5 8954781 (2)
    adenocarcinoma 0 1 12902987 (1)
    metastasis 0 1 19513521 (1)
    nsclc 0 2 9662339 (1), 10206277 (1)
    cancer 0 1 19653276 (1)

    Genetic Association Database (GAD): FOSL2
    Human Genome Epidemiology (HuGE) Navigator: FOSL2 (2 documents)
    Tumor Gene Database (TGDB): FOSL2

    Export disorders for FOSL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FOSL2 gene, integrated from 10 sources (see all 155):
    (articles sorted by number of sources associating them with FOSL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. (PubMed id 2107490)1, 2, 9 Matsui M.... Ishizaki R. (Oncogene 1990)
    2. A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. (PubMed id 21980299)1, 4 Bradfield J.P....Hakonarson H. (PLoS Genet. 2011)
    3. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (BMC Biol. 2009)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The transcription factor Fra-2 regulates the production of extracellular matrix in systemic sclerosis. (PubMed id 20039427)1, 9 Reich N....Distler J.H. (Arthritis Rheum. 2010)
    8. Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2) to chromosome 2p22-p23. (PubMed id 8954781)1, 9 Molven A....Berger R. (Genomics 1996)
    9. Role of Fra-2 in breast cancer: influence on tumor cell invasion and motility. (PubMed id 17393299)1, 9 Milde-Langosch K....LAPning T. (Breast Cancer Res. Treat. 2008)
    10. Transcription factor fos-related antigen-2 induces progressive peripheral vasculopathy in mice closely resembling human systemic sclerosis. (PubMed id 19933934)1, 9 Maurer B....Distler O. (Circulation 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2355 HGNC: 3798 AceView: FOSL2 Ensembl:ENSG00000075426 euGenes: HUgn2355
    ECgene: FOSL2 Kegg: 2355 H-InvDB: FOSL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FOSL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FOSL2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FOSL2 gene:
    Search GeneIP for patents involving FOSL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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