Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FOSL2 Gene

protein-coding GIFtS: 62
GCID: GC02P028615

FOS-like antigen 2

Explore 32 diseases affiliated with
FOSL2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
FOS-Like Antigen 2¹ ²
FRA2¹ ² ³
FRA-2² ³
FLJ23306¹
Fos-Related Antigen 2²

External Ids:	HGNC: 3798¹	Entrez Gene: 2355²	Ensembl: ENSG00000075426⁷	OMIM: 601575⁵	UniProtKB: P15408³

Export aliases for FOSL2 gene to outside databases

Previous GC identifers: GC02P028537 GC02P028708 GC02P028590 GC02P028527 GC02P028356

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FOSL2:

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that

can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS

proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FOSL2_HUMAN, P15408

Function: Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By

similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity)

Gene Wiki entry for FOSL2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FOSL2 gene promoter:
C/EBPbeta E2F E2F-1 p53 MyoD E2F-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FOSL2 promoter sequence

Search SABiosciences Chromatin IP Primers for FOSL2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOSL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3 Ensembl cytogenetic band: 2p23.2 HGNC cytogenetic band: 2p23.3

FOSL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOSL2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P028615: view genomic region (about GC identifiers)

Start:	28,615,315 bp from pter	End:	28,640,179 bp from pter
Size:	24,865 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FOSL2_HUMAN, P15408 (See protein sequence)

Recommended Name: Fos-related antigen 2

Size: 326 amino acids; 35193 Da

Subunit: Heterodimer (By similarity)

Subcellular location: Nucleus

Secondary accessions: B2RD58 B3KP27 B4DYV4 Q6FG46

Alternative splicing: 3 isoforms: P15408-1 P15408-2 P15408-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FOSL2: NX_P15408

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P15408

FOSL2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005244.1

ENSEMBL proteins:

ENSP00000368939 ENSP00000264716 ENSP00000396497 ENSP00000439303

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: FOSL2 OriGene Custom Protein Services for FOSL2
	GenScript Custom Purified and Recombinant Proteins Services for FOSL2
	Novus Biologicals FOSL2 Proteins Novus Biologicals FOSL2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FOSL2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--

FOSL2 for ontologies About GeneDecksing

FOSL2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: FOSL2 OriGene Custom Antibody Services for FOSL2
	GenScript Custom Superior Antibodies Services for FOSL2
	Novus Biologicals FOSL2 Antibodies
	Abcam antibodies for FOSL2
	Uscn Antibodies for FOSL2
	ThermoFisher Antibody for FOSL2

Assay Products for FOSL2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FOSL2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FOSL2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FOSL2 for domains About GeneDecksing

2 InterPro domains/families:

IPR004827 bZIP

IPR000837 Leuzip_Fos

Graphical View of Domain Structure for InterPro Entry P15408

ProtoNet protein and cluster: P15408

2 Blocks protein families:

IPB000837 Fos transforming protein signature

IPB011616 bZIP transcription factor

UniProtKB/Swiss-Prot: FOSL2_HUMAN, P15408

Similarity: Belongs to the bZIP family. Fos subfamily

Similarity: Contains 1 bZIP (basic-leucine zipper) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FOSL2_HUMAN, P15408

Function: Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By

similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity)

Genatlas biochemistry entry for FOSL2:

fos-related antigen 2

miRNA Products:		OriGene 3'-UTR Clone: FOSL2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOSL2
		8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate FOSL2 (see all 55):
		hsa-miR-579 hsa-miR-4254 hsa-miR-574-3p hsa-miR-25 hsa-miR-486-3p hsa-miR-342-3p hsa-miR-1304 hsa-miR-124

		SwitchGear 3'UTR luciferase reporter plasmid: FOSL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOSL2 (see all 4) OriGene shRNA RFP: FOSL2 OriGene siRNA: FOSL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOSL2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for FOSL2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOSL2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOSL2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FOSL2 (NM_005253)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOSL2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOSL2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FOSL2
		Search LifeMap BioReagents cell lines for FOSL2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOSL2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0043565	sequence-specific DNA binding	--	--
GO:0046983	protein dimerization activity	--	--

FOSL2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for FOSL2:

Big cells

Increased HPV18 LCR reporter a

Animal Models:
Mouse knock-out Fosl2^tm1Wag for FOSL2
7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Fosl2):

cellular	growth/size	hematopoietic system	homeostasis/metabolism	immune system
mortality/aging	skeleton

FOSL2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune response_IL-2 activation and signaling pathway

	Immune response IL-2 activation and signaling pathway	1.00			Immune response_IL-3 activation and signaling pathway	0.41
	Immune response_IL-2 activation and signaling pathway	1.00			Immune response IL-3 activation and signaling pathway	0.41

Immune response_IL-1 signaling pathway

Immune response_IL-1 signaling pathway

1.00

Immune response IL-1 signaling pathway

0.98

Mucin expression in CF via IL-6, IL-17 signaling pathways

Mucin expression in CF via IL-6, IL-17 signaling pathways

1.00

Mucin expression in CF via TLRs, EGFR signaling pathways

0.41

Immune response CD16 signaling in NK cells

Immune response CD16 signaling in NK cells

1.00

Immune response_CD16 signaling in NK cells

0.99

G-protein signaling_Ras family GTPases in kinase cascades (scheme)

Immune response Oncostatin M signaling via MAPK in human cells

0.39

Immune response_Oncostatin M signaling via MAPK in human cells

0.39

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for FOSL2

	Immune response CD16 signaling in NK cells
	Immune response IL-3 activation and signaling pathway
	Immune response Oncostatin M signaling via MAPK in human cells
	Immune response IL-1 signaling pathway
	Immune response IL-2 activation and signaling pathway

5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FOSL2 (see all 6)

	iNOS Signaling
	SMAD Signaling Network
	Ceramide Pathway
	ILK Signaling
	ITK and TCR Signaling

5/7 GeneGo (Thomson Reuters) Pathways for FOSL2 (see all 7)

	Mucin expression in CF via TLRs, EGFR signaling pathways
	Immune response IL-3 activation and signaling pathway
	Immune response CD16 signaling in NK cells
	Mucin expression in CF via IL-6, IL-17 signaling pathways
	Immune response IL-2 activation and signaling pathway

1 PharmGKB Pathway for FOSL2

Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

1 Kegg Pathway (Kegg details for FOSL2):

Osteoclast differentiation

FOSL2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FOSL2

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/24 Interacting proteins for FOSL2 (P15408³ ENSP00000264716⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 24)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
JUN	P05412³, ENSP00000360266⁴	I2D: score=4 STRING: ENSP00000360266
JUNB	P17275³, ENSP00000303315⁴	I2D: score=3 STRING: ENSP00000303315
JUND	P17535³, ENSP00000252818⁴	I2D: score=3 STRING: ENSP00000252818
MYC	P01106³, ENSP00000367207⁴	I2D: score=1 STRING: ENSP00000367207
FOS	P01100³, ENSP00000306245⁴	I2D: score=1 STRING: ENSP00000306245

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS	8954781
GO:0008219	cell death	TAS	8954781
GO:0048146	positive regulation of fibroblast proliferation	IEA	--

FOSL2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FOSL2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FOSL2
5 Novoseek chemical compound relationships for FOSL2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leucine	18.4	2	7568884 (1), 16829632 (1)
pd 98,059	14.1	1	10762717 (1)
n acetylcysteine	5.86	1	15989974 (1)
estrogen	4.58	5	18583549 (2), 19487245 (1)
calcium	0	1	9858557 (1)

Search CenterWatch for drugs/clinical trials and news about FOSL2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FOSL2 gene:

NM_005253.3

Unigene Cluster for FOSL2:

FOS-like antigen 2

Hs.220971 [show with all ESTs]

Unigene Representative Sequence: BX647822

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000460736 ENST00000379619(uc010ymi.2 uc021vfg.1) ENST00000264716(uc002rma.3)

ENST00000436647 ENST00000545753

miRNA Products:		OriGene 3'-UTR Clone: FOSL2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOSL2
		8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate FOSL2 (see all 55):
		hsa-miR-579 hsa-miR-4254 hsa-miR-574-3p hsa-miR-25 hsa-miR-486-3p hsa-miR-342-3p hsa-miR-1304 hsa-miR-124

		SwitchGear 3'UTR luciferase reporter plasmid: FOSL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOSL2 (see all 4) OriGene shRNA RFP: FOSL2 OriGene siRNA: FOSL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOSL2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOSL2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOSL2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FOSL2 (NM_005253)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOSL2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOSL2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOSL2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FOSL2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOSL2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOSL2

Additional cDNA sequence:

AK026959.1 AK055579.1 AK302622.1 AK315415.1 BC008899.2 BC022791.1 BC085197.1 BX647822.1

CR542262.1 X16706.1

10 DOTS entries:

DT.442351 DT.95279865 DT.95372886 DT.120945985 DT.91653540 DT.91763925 DT.120945947 DT.120945946

DT.92006784 DT.95291406

24/303 AceView cDNA sequences (see all 303):

AI560860 N49170 BU739117 BF940699 BM818794 AI288390 BQ675048 CA310602

AW016642 CA942758 CB124542 AA348626 CB160140 AA313755 AL036157 AI246689

AA036901 BG740183 BU538259 AI982980 AW517421 CK904433 AI249705 AI083545

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for FOSL2 About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	·	7d
SP1:			-		-		-		-										-
SP2:							-		-										-		-
SP3:							-		-
SP4:																			-		-
SP5:													-		-				-		-

ECgene alternative splicing isoforms for FOSL2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FOSL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACATTTCATC

About this image

FOSL2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Cerebral Cortex

Brain

Cartilage

Lumbar Intervertebral Disc

Cartilage

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

See FOSL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FOSL2

SOURCE GeneReport for Unigene cluster: Hs.220971

SABiosciences Custom PCR Arrays for FOSL2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOSL2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FOSL2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOSL2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOSL2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOSL2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FOSL2 gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FOSL2¹	FOS-like antigen 2	80.23(n) 88.2(a)		421416 NM_001045836.1 NP_001039301.1
lizard (Anolis carolinensis)	Reptilia	FOSL2⁶	--	81(a)	1 ↔ 1	2(125823843-125848478)
African clawed frog (Xenopus laevis)	Amphibia	gene²	fos-related antigen-2	77.27(n)		U37374.1
zebrafish (Danio rerio)	Actinopterygii	fosl2¹	fos-like antigen 2	67.18(n) 68.92(a)		558921 NM_001082998.1 NP_001076467.1
fruit fly (Drosophila melanogaster)	Insecta	kay⁶	kayak	8(a)	1 → many	3R(25592497-25619838)

ENSEMBL Gene Tree for FOSL2 (if available)
TreeFam Gene Tree for FOSL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FOSL2 gene

FOSL1² JDP2² ATF3² FOSB² FOS²

6 SIMAP similar genes for FOSL2 using alignment to 2 protein entries: FOSL2_HUMAN (see all proteins):

ATF3 JDP2 BATF FOS FOSB FOSL1

FOSL2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75967881^1,2	F,	--	28354167(+)	`CTGCAC/TTTACT`	1	--	int¹		2		CSA	4
rs112482080^1,2	C,	--	28355215(+)	`GGGCGG/ACCGGA`	1	--	int¹		2		CSA WA	120
rs11538577^1,2	C	--	28356573(+)	`GTCCCC/TGCTGA`	1	--	int¹		1		NA	2
rs62143061^1,2	C,F,	--	28358254(+)	`TCTTCC/TCTCTG`	1	--	us2k¹		4		NA CSA	125
rs75482533^1,2	F,	--	28358397(+)	`TGCTTC/TCCAGC`	1	--	us2k¹		1		WA	118
rs77199907^1,2	C,	--	28358478(+)	`TCTCCC/TGTTCG`	1	--	us2k¹		2		CSA WA	120
rs72858830^1,2	C,	--	28358597(+)	`TATTAC/AAATCT`	1	--	us2k¹		2		WA	120
rs80262716^1,2		--	28358622(+)	`GCATAC/GACCCT`	1	--	us2k¹		0	--	--	--	--
rs11886124^1,2	C,H,	--	28358811(+)	`ATTACC/TGAAGC`	1	--	us2k¹		3		NA WA	124
rs13413498^1,2	C,F,	--	28359105(+)	`GGACTG/AACCTC`	1	--	us2k¹		3		CSA WA	122

HapMap Linkage Disequilibrium report for FOSL2 (28615315 - 28640179 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FOSL2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOSL2

DNA2.0 Custom Variant and Variant Library Synthesis for FOSL2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FOSL2 for disorders           About GeneDecksing

OMIM gene information: 601575    OMIM disorders: --

20/32 diseases for FOSL2 (see all 32):    About MalaCards

human t-cell leukemia virus type 1 anaplastic large cell lymphoma b-cell lymphomas adult t-cell leukemia

brain injury t-cell leukemia familial breast cancer squamous cell carcinoma

pulmonary fibrosis embryonal carcinoma breast cancer neurofibromatosis

copd endometrial cancer oral cancer leukemia

pheochromocytoma fibrosis homocysteine ovarian carcinoma

8 Novoseek disease relationships for FOSL2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	7.63	6	17393299 (3), 15319566 (1), 18088579 (1), 17009623 (1)
tumors	6.96	13	17393299 (2), 10502734 (2), 15514944 (1), 11570575 (1) (see all 8)
carcinoma	6.06	4	15319566 (1), 15923159 (1), 17393299 (1)
leukemia	0	5	8954781 (2)
adenocarcinoma	0	1	12902987 (1)
metastasis	0	1	19513521 (1)
nsclc	0	2	9662339 (1), 10206277 (1)
cancer	0	1	19653276 (1)

Human Genome Epidemiology (HuGE) Navigator: FOSL2 (2 documents)
Tumor Gene Database (TGDB): FOSL2

Export disorders for FOSL2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FOSL2 gene, integrated from 9 sources (see all 149):
(articles sorted by number of sources associating them with FOSL2)

Utopia: connect your pdf to the dynamic
world of online information

Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. (PubMed id 2107490)^{1, 2, 9} Matsui M.... Ishizaki R. (1990)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The transcription factor Fra-2 regulates the producti on of extracellular matrix in systemic sclerosis. (PubMed id 20039427)^{1, 9} Reich N....Distler J.H. (2010)
Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2) to chromosome 2p22-p23. (PubMed id 8954781)^{1, 9} Molven A....Berger R. (1996)
Role of Fra-2 in breast cancer: influence on tumor cell invasion and motility. (PubMed id 17393299)^{1, 9} Milde-Langosch K....Loning T. (2008)
Transcription factor fos-related antigen-2 induces pr ogressive peripheral vasculopathy in mice closely resembling human systemic scl erosis. (PubMed id 19933934)^{1, 9} Maurer B....Distler O. (2009)
Aberrant expression of Fra-2 promotes CCR4 expression and cell proliferation in adult T-cell leukemia. (PubMed id 18071306)^{1, 9} Nakayama T....Yoshie O. (2008)
Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1. (PubMed id 18641127)^{1, 9} Eferl R....Wagner E.F. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2355	HGNC: 3798	AceView: FOSL2	Ensembl:ENSG00000075426	euGenes: HUgn2355
ECgene: FOSL2	Kegg: 2355	H-InvDB: FOSL2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FOSL2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FOSL2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for FOSL2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FOSL2 gene:
Search GeneIP for patents involving FOSL2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for FOSL2		OriGene shRNA RFP for FOSL2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOSL2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOSL2
	OriGene Protein Over-expression Lysate for FOSL2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for FOSL2		OriGene 3'-UTR Clone for FOSL2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOSL2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOSL2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for FOSL2		OriGene Custom Protein Services for FOSL2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FOSL2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOSL2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOSL2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOSL2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOSL2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOSL2

	GenScript Custom Purified and Recombinant Proteins Services for FOSL2		GenScript cDNA clones with any tag delivered in your preferred vector for FOSL2
	GenScript Custom Assay Services for FOSL2		GenScript Custom Superior Antibodies Services for FOSL2
	GenScript Custom overexpressing Cell Line Services for FOSL2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in FOSL2 promoter
	Search Chromatin IP Primers for FOSL2
	RT² qPCR Primer Assay in human, mouse, rat FOSL2
	GNC Network for FOSL2
	SABiosciences PCR Arrays including human, mouse, rat FOSL2

Search Tocris compounds for FOSL2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	FOSL2 antibodies
	FOSL2 proteins
	FOSL2 lysates

	Antibodies for FOSL2
	See all of Abcam's Antibodies, Kits and Proteins for FOSL2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

FOSL2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for FOSL2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOSL2

	SwitchGear 3'UTR luciferase reporter plasmids for FOSL2
	SwitchGear Promoter luciferase reporter plasmids for FOSL2

ThermoFisher Antibody for FOSL2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOSL2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes FOSL2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

FOSL2 Gene

FOS-like antigen 2

Aliases
for FOSL2 gene

Summaries
for FOSL2 gene

Genomic Views
for FOSL2 gene

Proteins
for FOSL2 gene

Protein Domains /
Families
for FOSL2 gene

Function
for FOSL2 gene

Pathways & Interactions
for FOSL2 gene

Drugs & Compounds
for FOSL2 gene

Transcripts
for FOSL2 gene

Expression
for FOSL2 gene

Orthologs
for FOSL2 gene

Paralogs
for FOSL2 gene

Genomic Variants
for FOSL2 gene

Disorders / Diseases
for FOSL2 gene

Publications
for FOSL2 gene

External Searches for FOSL2 gene

Genome Databases showing FOSL2 gene

Other Databases showing FOSL2 gene

Specialized Databases showing FOSL2 gene

Intellectual Property
for FOSL2 gene

Products
for FOSL2 gene

View Random Gene

Advanced Search

Export list of displayed genes

FOSL2 Gene

FOS-like antigen 2

Aliasesfor FOSL2 gene

Summariesfor FOSL2 gene

Genomic Viewsfor FOSL2 gene

Proteinsfor FOSL2 gene

Protein Domains /Familiesfor FOSL2 gene

Functionfor FOSL2 gene

Pathways & Interactionsfor FOSL2 gene

Drugs & Compoundsfor FOSL2 gene

Transcriptsfor FOSL2 gene

Expression for FOSL2 gene

Orthologsfor FOSL2 gene

Paralogsfor FOSL2 gene

Genomic Variantsfor FOSL2 gene

Disorders / Diseasesfor FOSL2 gene

Publicationsfor FOSL2 gene

External Searches for FOSL2 gene

Genome Databases showing FOSL2 gene

Other Databases showing FOSL2 gene

Specialized Databases showing FOSL2 gene

Intellectual Propertyfor FOSL2 gene

Productsfor FOSL2 gene

View Random Gene

Aliases
for FOSL2 gene

Summaries
for FOSL2 gene

Genomic Views
for FOSL2 gene

Proteins
for FOSL2 gene

Protein Domains /
Families
for FOSL2 gene

Function
for FOSL2 gene

Pathways & Interactions
for FOSL2 gene

Drugs & Compounds
for FOSL2 gene

Transcripts
for FOSL2 gene

Expression
for FOSL2 gene

Orthologs
for FOSL2 gene

Paralogs
for FOSL2 gene

Genomic Variants
for FOSL2 gene

Disorders / Diseases
for FOSL2 gene

Publications
for FOSL2 gene

Intellectual Property
for FOSL2 gene

Products
for FOSL2 gene