External Ids for FOSL2 Gene
Previous GeneCards Identifiers for FOSL2 Gene
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]
GeneCards Summary for FOSL2 Gene
FOSL2 (FOS Like Antigen 2) is a Protein Coding gene. Among its related pathways are Osteoclast differentiation and Tacrolimus/Cyclosporine Pathway, Pharmacodynamics. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is FOSL1.
UniProtKB/Swiss-Prot for FOSL2 Gene
Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.