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Aliases for FOSL1 Gene

Aliases for FOSL1 Gene

  • FOS-Like Antigen 1 2 3
  • Fra-1 3 4
  • FRA1 3 4
  • FOS-Like Antigen-1 3
  • FRA 3

External Ids for FOSL1 Gene

Previous GeneCards Identifiers for FOSL1 Gene

  • GC11M068193
  • GC11M067341
  • GC11M065435
  • GC11M065416
  • GC11M065659
  • GC11M061986

Summaries for FOSL1 Gene

Entrez Gene Summary for FOSL1 Gene

  • The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for FOSL1 Gene

FOSL1 (FOS-Like Antigen 1) is a Protein Coding gene. Diseases associated with FOSL1 include pfeiffer syndrome. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Akt Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is FOSL2.

Gene Wiki entry for FOSL1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOSL1 Gene

Genomics for FOSL1 Gene

Regulatory Elements for FOSL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FOSL1 Gene

Chromosome:
11
Start:
65,892,049 bp from pter
End:
65,900,573 bp from pter
Size:
8,525 bases
Orientation:
Minus strand

Genomic View for FOSL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOSL1 Gene

Proteins for FOSL1 Gene

  • Protein details for FOSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15407-FOSL1_HUMAN
    Recommended name:
    Fos-related antigen 1
    Protein Accession:
    P15407
    Secondary Accessions:
    • B4DR11
    • Q6FG51

    Protein attributes for FOSL1 Gene

    Size:
    271 amino acids
    Molecular mass:
    29413 Da
    Quaternary structure:
    • Heterodimer.

    Alternative splice isoforms for FOSL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOSL1 Gene

Proteomics data for FOSL1 Gene at MOPED

Post-translational modifications for FOSL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FOSL1 (FRA1)
  • Cloud-Clone Corp. Antibodies for FOSL1

No data available for DME Specific Peptides for FOSL1 Gene

Domains & Families for FOSL1 Gene

Gene Families for FOSL1 Gene

Protein Domains for FOSL1 Gene

Graphical View of Domain Structure for InterPro Entry

P15407

UniProtKB/Swiss-Prot:

FOSL1_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. Fos subfamily.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. Fos subfamily.
genes like me logo Genes that share domains with FOSL1: view

Function for FOSL1 Gene

Molecular function for FOSL1 Gene

GENATLAS Biochemistry:
fos antigen-like 1,target molecule for retinoid action in pancreatic carcinoma cell line Dan-G

Gene Ontology (GO) - Molecular Function for FOSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding --
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding IBA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding --
genes like me logo Genes that share ontologies with FOSL1: view
genes like me logo Genes that share phenotypes with FOSL1: view

Animal Model Products

Transcription Factor Targets for FOSL1 Gene

Selected GeneGlobe predicted Target genes for FOSL1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOSL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models and HOMER Transcription for FOSL1 Gene

Localization for FOSL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOSL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOSL1 Gene COMPARTMENTS Subcellular localization image for FOSL1 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for FOSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IEA --
GO:0042734 presynaptic membrane IEA --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with FOSL1: view

Pathways & Interactions for FOSL1 Gene

genes like me logo Genes that share pathways with FOSL1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for FOSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 10918580
GO:0006366 transcription from RNA polymerase II promoter TAS 2107490
GO:0006935 chemotaxis TAS 10918580
genes like me logo Genes that share ontologies with FOSL1: view

No data available for SIGNOR curated interactions for FOSL1 Gene

Drugs & Compounds for FOSL1 Gene

(11) Drugs for FOSL1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nitric Oxide Approved Pharma 540
Vitamin C Approved Nutra 398,398
cyclic amp Experimental Pharma 0
okadaic acid Experimental Pharma 0
arachidonic acid Experimental Nutra Potentiation, Activator 27

(10) Additional Compounds for FOSL1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
12-O-Tetradecanoylphorbol 13-acetate
Glycogen
  • Animal starch
  • Glycogen
  • Liver starch
  • Lyoglycogen
  • Phytoglycogen
9005-79-2
H2O2
Matrigel
PD 98,059
genes like me logo Genes that share compounds with FOSL1: view

Transcripts for FOSL1 Gene

Unigene Clusters for FOSL1 Gene

FOS-like antigen 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOSL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOSL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1:
SP2:
SP3: - -
SP4: -
SP5: -
SP6: - -

Relevant External Links for FOSL1 Gene

GeneLoc Exon Structure for
FOSL1
ECgene alternative splicing isoforms for
FOSL1

Expression for FOSL1 Gene

mRNA expression in normal human tissues for FOSL1 Gene

mRNA differential expression in normal tissues according to GTEx for FOSL1 Gene

This gene is overexpressed in Minor Salivary Gland (x5.4), Esophagus - Mucosa (x4.5), and Adipose - Visceral (Omentum) (x4.2).

Protein differential expression in normal tissues from HIPED for FOSL1 Gene

This gene is overexpressed in Cardia (35.6) and Retina (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FOSL1 Gene



SOURCE GeneReport for Unigene cluster for FOSL1 Gene Hs.283565

genes like me logo Genes that share expression patterns with FOSL1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FOSL1 Gene

Orthologs for FOSL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOSL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOSL1 35
  • 88.18 (n)
  • 93.66 (a)
FOSL1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOSL1 35
  • 88.56 (n)
  • 91.42 (a)
FOSL1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fosl1 35
  • 83.27 (n)
  • 90.71 (a)
Fosl1 16
Fosl1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOSL1 35
  • 99.51 (n)
  • 99.26 (a)
FOSL1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fosl1 35
  • 81.3 (n)
  • 87.82 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia FOSL1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOSL1 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fosl1 35
  • 60.36 (n)
  • 64.18 (a)
zebrafish
(Danio rerio)
Actinopterygii fosl1a 35
  • 60.43 (n)
  • 62.98 (a)
fosl1a 36
  • 44 (a)
OneToMany
fosl1b 36
  • 58 (a)
OneToMany
fosl1b 36
  • 28 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta kay 36
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToMany
Species with no ortholog for FOSL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOSL1 Gene

ENSEMBL:
Gene Tree for FOSL1 (if available)
TreeFam:
Gene Tree for FOSL1 (if available)

Paralogs for FOSL1 Gene

Paralogs for FOSL1 Gene

(3) SIMAP similar genes for FOSL1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for FOSL1 Gene

genes like me logo Genes that share paralogs with FOSL1: view

Variants for FOSL1 Gene

Sequence variations from dbSNP and Humsavar for FOSL1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs507062 -- 65,894,185(+) CCTCA(C/T)GGTGG intron-variant
rs536258 -- 65,895,068(+) atgtt(G/T)ggatt intron-variant
rs536287 -- 65,895,083(+) ggggg(A/G)gtcac intron-variant
rs536383 -- 65,895,108(+) TTTTT(A/T)AAAAA intron-variant
rs538268 -- 65,895,317(+) gacac(C/G/T)gtttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOSL1 Gene

Variant ID Type Subtype PubMed ID
nsv897736 CNV Loss 21882294
dgv393e1 CNV Complex 17122850
dgv1185n71 CNV Loss 21882294
nsv897764 CNV Loss 21882294
nsv832191 CNV Loss 17160897
nsv39194 CNV Loss 16902084

Variation tolerance for FOSL1 Gene

Residual Variation Intolerance Score: 46.38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOSL1 Gene

HapMap Linkage Disequilibrium report
FOSL1

PCR Panel Products

  • Copy Number PCR Panels: for FOSL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOSL1 Gene

Disorders for FOSL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FOSL1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
pfeiffer syndrome
  • craniofacial-skeletal-dermatologic dysplasia
- elite association
Search FOSL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FOSL1

Genetic Association Database (GAD)
FOSL1
Human Genome Epidemiology (HuGE) Navigator
FOSL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOSL1
genes like me logo Genes that share disorders with FOSL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOSL1 Gene

Publications for FOSL1 Gene

  1. Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. (PMID: 2107490) Matsui M. … Ishizaki R. (Oncogene 1990) 2 23 67
  2. Activation of AP-1 transcription factors differentiates FGF2 and vascular endothelial growth factor regulation of endothelial nitric-oxide synthase expression in placental artery endothelial cells. (PMID: 20371606) Mata-Greenwood E. … Chen D.B. (J. Biol. Chem. 2010) 23 67
  3. c-Jun-NH2 terminal kinase (JNK)-mediates AP-1 activation by thioredoxin: phosphorylation of cJun, JunB, and Fra-1. (PMID: 19859790) Das K.C. … Muniyappa H. (Mol. Cell. Biochem. 2010) 23 67
  4. AP-1 (Fra-1/c-Jun)-mediated induction of expression of matrix metalloproteinase-2 is required for 15S-hydroxyeicosatetraenoic acid-induced angiogenesis. (PMID: 20353950) Singh N.K. … Rao G.N. (J. Biol. Chem. 2010) 23 67
  5. Fra-1 protooncogene regulates IL-6 expression in macrophages and promotes the generation of M2d macrophages. (PMID: 20386569) Wang Q. … Wang Y. (Cell Res. 2010) 23 67

Products for FOSL1 Gene

Sources for FOSL1 Gene

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