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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FOSL1 Gene

protein-coding GIFtS: 64
GCID: GC11M065659

FOS-like antigen 1

Explore 41 diseases affiliated with
FOSL1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
FOS-Like Antigen 1¹ ²		FOS-Like Antigen-1²
Fra-1¹		Fos-Related Antigen 1²
FRA1² ³		FRA-1³
FRA²

External Ids:	HGNC: 13718¹	Entrez Gene: 8061²	Ensembl: ENSG00000175592⁷	OMIM: 136515⁵	UniProtKB: P15407³

Export aliases for FOSL1 gene to outside databases

Previous GC identifers: GC11M068193 GC11M067341 GC11M065909 GC11M065435 GC11M065416 GC11M061986

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FOSL1:

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that

can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS

proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. (provided by

RefSeq, Jul 2008)

Gene Wiki entry for FOSL1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FOSL1 gene promoter:
TBP STAT1 p53 ATF-2 p300 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FOSL1 promoter sequence

Search SABiosciences Chromatin IP Primers for FOSL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOSL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13

FOSL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOSL1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M065659: view genomic region (about GC identifiers)

Start:	65,659,490 bp from pter	End:	65,668,044 bp from pter
Size:	8,555 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FOSL1_HUMAN, P15407 (See protein sequence)

Recommended Name: Fos-related antigen 1

Size: 271 amino acids; 29413 Da

Subunit: Heterodimer (By similarity)

Subcellular location: Nucleus

Secondary accessions: Q6FG51

Explore the universe of human proteins at neXtProt for FOSL1: NX_P15407

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P15407

FOSL1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005429.1

ENSEMBL proteins:

ENSP00000412931 ENSP00000393302 ENSP00000310170 ENSP00000436276 ENSP00000431594

ENSP00000434350

Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FOSL1

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005792	microsome	--	--
GO:0005829	cytosol	IEA	--
GO:0019717	synaptosome	--	--
GO:0042734	presynaptic membrane	IEA	--

FOSL1 for ontologies About GeneDecksing

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	Uscn Antibodies for FOSL1
	ThermoFisher Antibodies for FOSL1

Assay Products for FOSL1:

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	GenScript Custom Assay Services for FOSL1
	Cell Signaling Technology (CST) Sandwich ELISA Kits for FOSL1 (FRA1)
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FOSL1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FOSL1 for domains About GeneDecksing

2 InterPro domains/families:

IPR004827 bZIP

IPR000837 Leuzip_Fos

Graphical View of Domain Structure for InterPro Entry P15407

ProtoNet protein and cluster: P15407

2 Blocks protein families:

IPB000837 Fos transforming protein signature

IPB011616 bZIP transcription factor

UniProtKB/Swiss-Prot: FOSL1_HUMAN, P15407

Similarity: Belongs to the bZIP family. Fos subfamily

Similarity: Contains 1 bZIP (basic-leucine zipper) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

Genatlas biochemistry entry for FOSL1:

fos antigen-like 1,target molecule for retinoid action in pancreatic carcinoma cell line Dan-G

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOSL1
		8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate FOSL1 (see all 34):
		hsa-miR-15a hsa-miR-503 hsa-miR-301a hsa-miR-449a hsa-miR-4267 hsa-miR-424 hsa-miR-29a* hsa-miR-15b

		SwitchGear 3'UTR luciferase reporter plasmid: FOSL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FOSL1
		Search LifeMap BioReagents cell lines for FOSL1

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for FOSL1

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IEA	--
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0005515	protein binding	IPI	19060904
GO:0016563	transcription activator activity	--	--

FOSL1 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for FOSL1:

Decreased cell number and incr

Increased HPV18 LCR reporter a

Synthetic lethal with imatinib

Animal Models:
7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Fosl1):

cardiovascular system	embryogenesis	growth/size	hematopoietic system	mortality/aging
normal	skeleton

FOSL1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/27 super-pathways (see all 27) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune response_IL-2 activation and signaling pathway

	Immune response IL-2 activation and signaling pathway	1.00			Immune response_IL-3 activation and signaling pathway	0.41
	Immune response_IL-2 activation and signaling pathway	1.00			Immune response IL-3 activation and signaling pathway	0.41

Wnt Signaling Pathway

	Wnt Signaling Pathway	1.00			DNA damage response (only ATM dependent)	0.35
	Wnt Signaling Pathway and Pluripotency	0.55			Wnt signaling pathway	0.30

Transcription_Role of VDR in regulation of genes involved in osteoporosis

Transcription_Role of VDR in regulation of genes involved in osteoporosis

1.00

Transcription Role of VDR in regulation of genes involved in osteoporosis

0.80

Immune response_IL-1 signaling pathway

Immune response_IL-1 signaling pathway

1.00

Immune response IL-1 signaling pathway

0.98

Mucin expression in CF via IL-6, IL-17 signaling pathways

Mucin expression in CF via IL-6, IL-17 signaling pathways

1.00

Mucin expression in CF via TLRs, EGFR signaling pathways

0.41

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 EMD Millipore Pathways for FOSL1 (see all 6)

	Transcription Role of VDR in regulation of genes involved in osteoporosis
	Immune response CD16 signaling in NK cells
	Immune response IL-3 activation and signaling pathway
	Immune response Oncostatin M signaling via MAPK in human cells
	Immune response IL-1 signaling pathway

5 R&D Systems Pathways for FOSL1

	Inflammasome Activation Pathways
	Adipocytokines & Insulin Signaling
	Th1 Differentiation
	Toll-Like receptor Signaling Pathways
	TGF-beta Signaling Pathways

5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FOSL1 (see all 9)

	ERK5 Signaling
	iNOS Signaling
	SMAD Signaling Network
	Ceramide Pathway
	ILK Signaling

1 Cell Signaling Technology (CST) Pathway for FOSL1

MAP Kinase Signaling

5/8 GeneGo (Thomson Reuters) Pathways for FOSL1 (see all 8)

	Transcription Role of VDR in regulation of genes involved in osteoporosis
	Immune response CD16 signaling in NK cells
	Mucin expression in CF via IL-6, IL-17 signaling pathways
	Immune response IL-2 activation and signaling pathway
	Mucin expression in CF via TLRs, EGFR signaling pathways

5/8 BioSystems Pathways for FOSL1 (see all 8)

	Wnt Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	DNA damage response (only ATM dependent)
	Calcium signaling in the CD4+ TCR pathway
	Validated targets of C-MYC transcriptional activation

1 PharmGKB Pathway for FOSL1

Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

2 Kegg Pathways (Kegg details for FOSL1):

	Wnt signaling pathway
	Osteoclast differentiation

FOSL1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FOSL1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/64 Interacting proteins for FOSL1 (P15407^{1, 2, 3} ENSP00000310170⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 64)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CALCOCO1	Q9P1Z2²^,³, ENSP00000262059⁴	MINT-68294 I2D: score=5 STRING: ENSP00000262059
LDOC1	O95751¹^,²^,³, ENSP00000359557⁴	EBI-744510,EBI-740738 MINT-66527 I2D: score=5 STRING: ENSP00000359557
JUNB	P17275³, ENSP00000303315⁴	I2D: score=6 STRING: ENSP00000303315
JUN	P05412³, ENSP00000360266⁴	I2D: score=4 STRING: ENSP00000360266
JUND	P17535³, ENSP00000252818⁴	I2D: score=1 STRING: ENSP00000252818

About this table

Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001701	in utero embryonic development	IEA	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS	10918580
GO:0006366	transcription from RNA polymerase II promoter	TAS	2107490
GO:0006935	chemotaxis	TAS	10918580
GO:0006968	cellular defense response	TAS	10918580

FOSL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FOSL1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FOSL1
10/21 Novoseek chemical compound relationships for FOSL1 gene (see all 21) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
12-o-tetradecanoylphorbol 13-acetate	49.9	11	13679379 (5), 8389757 (1), 7761434 (1), 17082637 (1) (see all 5)
phorbol	30.5	1	9662339 (1)
pdtc	29.8	1	8985358 (1)
matrigel	27	2	15319566 (1), 15608675 (1)
pd 98,059	26.1	2	10762717 (1), 15615716 (1)
sb 203580	24.5	1	10762717 (1)
okadaic acid	21.5	3	1851743 (1), 1316910 (1)
leucine	21.2	5	19251936 (1), 7568884 (1), 16829632 (1), 18083929 (1)
retinoid	17.6	4	10217407 (3)
glycogen	13.8	1	19435822 (1)

Search CenterWatch for drugs/clinical trials and news about FOSL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FOSL1 gene:

NM_005438.3

Unigene Cluster for FOSL1:

FOS-like antigen 1

Hs.283565 [show with all ESTs]

Unigene Representative Sequence: NM_005438

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000455710 ENST00000448083 ENST00000312562(uc001ogg.1 uc010ros.1)

ENST00000531493 ENST00000532401 ENST00000534222

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOSL1
		8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate FOSL1 (see all 34):
		hsa-miR-15a hsa-miR-503 hsa-miR-301a hsa-miR-449a hsa-miR-4267 hsa-miR-424 hsa-miR-29a* hsa-miR-15b

		SwitchGear 3'UTR luciferase reporter plasmid: FOSL1 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOSL1

Additional cDNA sequence:

AK222902.1 AK293297.1 AK299050.1 AK313718.1 BC016648.1 CR542257.1 CR542278.1 S68214.1

X16707.1

10 DOTS entries:

DT.448961 DT.100028987 DT.91974650 DT.100798399 DT.115680 DT.100798397 DT.100798398 DT.100798400

DT.212867 DT.97810916

24/406 AceView cDNA sequences (see all 406):

AA279993 BM763039 CB123625 AI831486 BF435136 BI192947 BM554571 AI298985

AI916941 CB112214 AW009355 BC016648 CR608946 CA448806 BU625695 BU627122

BM453790 CA454182 BM423473 BM558467 AW139351 S68214 CB136865 CK823076

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FOSL1 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	·	4c	·	4d
SP1:
SP2:
SP3:							-		-
SP4:											-
SP5:									-

ECgene alternative splicing isoforms for FOSL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FOSL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCACACCCT

About this image

FOSL1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FOSL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FOSL1

SOURCE GeneReport for Unigene cluster: Hs.283565

SABiosciences Expression via Pathway-Focused PCR Arrays including FOSL1 (see all 7):

Stem Cell Transcription Factors in human mouse rat

WNT Signaling Targets in human mouse rat

WNT Signaling Pathway in human mouse rat

T Helper Cell Differentiation in human mouse rat

Signal Transduction PathwayFinder in human mouse rat

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In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for FOSL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FOSL1 gene from 3/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	FOSL1⁶	--	55(a)	1 ↔ 1	GL344183.1(26663-32768)
zebrafish (Danio rerio)	Actinopterygii	fosl1a¹	FOS-like antigen 1a	58.43(n) 59.32(a)		564241 NM_001161552.1 NP_001155024.1
fruit fly (Drosophila melanogaster)	Insecta	kay⁶	kayak	8(a)	1 → many	3R(25592497-25619838)

ENSEMBL Gene Tree for FOSL1 (if available)
TreeFam Gene Tree for FOSL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FOSL1 gene

JDP2² ATF3² FOSB² FOS² FOSL2²

3 SIMAP similar genes for FOSL1 using alignment to 6 protein entries: FOSL1_HUMAN (see all proteins):

ATF3 FOSL2 FOSB

FOSL1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for FOSL1
PGOHUM00000246070

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76584642^1,2	C,F,	--	65659199(+)	`NNNNCT/GGCAGA`	2	--	int¹ ds500¹		1		NA	120
rs57225106^1,2		--	65659389(+)	`CCACTC/TGGCCG`	2	--	ds500¹ int¹		0	--	--	--	--
rs35831421^1,2	F,	--	65659450(+)	`CAGCAA/G/TCACTG`	2	--	int¹ ds500¹		4		NA CSA	125
rs55904337^1,2	C	--	65659778(+)	`GCTGTA/GGAGGC`	1	--	ut3¹		0	--	--	--	--
rs1151520^1,2	C,F,A,H,	--	65659813(+)	`TCTCAA/GAGCTG`	1	--	ut3¹		17		MN EA NA NS WA	1626
rs182954794^1,2		--	65660104(+)	`TGGCAC/TAAATG`	1	--	ut3¹		0	--	--	--	--
rs55740724^1,2	C	--	65660311(+)	`GGAGGA/GGACAT`	1	--	ut3¹		0	--	--	--	--
rs142119979^1,2	F	--	65660378(+)	`GTTGGA/GGAGCC`	2	S	syn¹		1		NA	4516
rs150615201^1,2	F	--	65660502(+)	`GGGAGG/AGTGTG`	2	/P /L	mis¹		1		NA	4548
rs200326243^1,2		--	65660518(+)	`GAGTGC/TGGGGG`	2	T A	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FOSL1 (65659490 - 65668044 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FOSL1
2 CNVs: 3855 5630

SABiosciences Cancer Mutation PCR Assays

1 SABiosciences qBiomarker Copy Number PCR Array containing FOSL1:

WNT Signaling

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FOSL1 for disorders           About GeneDecksing

OMIM gene information: 136515    OMIM disorders: --

20/41 diseases for FOSL1 (see all 41):    About MalaCards

estrogen-receptor negative breast cancer human t-cell leukemia virus type 1 oral squamous cell carcinoma pfeiffer syndrome

squamous cell carcinoma interstitial lung disease osteosclerosis breast cancer

familial breast cancer cervicitis cervical carcinoma carcinoma

colon carcinoma cervical cancer t-cell leukemia embryonal carcinoma

oral cancer pheochromocytoma glioblastoma osteoporosis

1 disease from the University of Copenhagen DISEASES database for FOSL1:

Cancer

10/25 Novoseek disease relationships for FOSL1 gene (see all 25) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia t-cell	44.7	1	11145887 (1)
tumors	35	30	15514944 (3), 10502734 (2), 12209953 (1), 12692267 (1) (see all 19)
neoplastic disease	32	2	17254320 (1), 14519134 (1)
glioblastoma multiforme	31	5	18172271 (1), 15831677 (1)
epithelial tumor	23.3	1	9819396 (1)
colon carcinoma	22.3	1	18098284 (1)
hnscc	18.7	2	16045542 (1)
cancer	16.6	9	18606715 (3), 16784822 (2), 17371847 (1), 18288638 (1) (see all 5)
lung tumor	15.8	1	18288638 (1)
colon cancer	10.6	1	12209953 (1)

Human Genome Epidemiology (HuGE) Navigator: FOSL1 (8 documents)

Export disorders for FOSL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FOSL1 gene, integrated from 9 sources (see all 251):
(articles sorted by number of sources associating them with FOSL1)

Utopia: connect your pdf to the dynamic
world of online information

Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. (PubMed id 2107490)^{1, 2, 3, 9} Matsui M.... Ishizaki R. (1990)
Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals. (PubMed id 8230424)^{1, 2, 9} Tsuchiya H.... Seiki M. (1993)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
FRA-1 protein overexpression is a feature of hyperplastic and neoplastic breast disorders. (PubMed id 17254320)^{1, 9} Chiappetta G....Fusco A. (2007)
Fra-1 governs cell migration via modulation of CD44 expression in human mesotheliomas. (PubMed id 18096084)^{1, 9} Ramos-Nino M.E....Mossman B.T. (2007)
Fos-related antigen 1 modulates malignant features of glioma cells. (PubMed id 15831677)^{1, 9} Debinski W. and Gibo D.M. (2005)
Ubiquitin-independent proteasomal degradation of Fra-1 is antagonized by Erk1/2 pathway-mediated phosphorylation of a unique C-terminal destabilizer. (PubMed id 17371847)^{1, 9} Basbous J....Piechaczyk M. (2007)
Fra-1 and Stat3 synergistically regulate activation of human MMP-9 gene. (PubMed id 17572495)^{1, 9} Song Y....Guo N. (2008)
Mitogen regulated induction of FRA-1 proto-oncogene is controlled by the transcription factors binding to both serum and TPA response elements. (PubMed id 15806162)^{1, 9} Adiseshaiah P....Reddy S.P. (2005)
FRA-1 expression level regulates proliferation and invasiveness of breast cancer cells. (PubMed id 15608675)^{1, 9} Belguise K....Chalbos D. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8061	HGNC: 13718	AceView: FOSL1	Ensembl:ENSG00000175592	euGenes: HUgn8061
ECgene: FOSL1	Kegg: 8061	H-InvDB: FOSL1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FOSL1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FOSL1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for FOSL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FOSL1 gene:
Search GeneIP for patents involving FOSL1

GeneCards and IP:
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