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Aliases for FOSL1 Gene

Aliases for FOSL1 Gene

  • FOS Like 1, AP-1 Transcription Factor Subunit 2 3 5
  • Fra-1 3 4
  • FRA1 3 4
  • FOS Like 1, AP-1 Trancription Factor Subunit 3
  • Fos-Related Antigen 1 3
  • FOS Like Antigen 1 2
  • FOS-Like Antigen-1 3
  • FRA 3

External Ids for FOSL1 Gene

Previous GeneCards Identifiers for FOSL1 Gene

  • GC11M068193
  • GC11M067341
  • GC11M065435
  • GC11M065416
  • GC11M065659
  • GC11M061986

Summaries for FOSL1 Gene

Entrez Gene Summary for FOSL1 Gene

  • The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for FOSL1 Gene

FOSL1 (FOS Like 1, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with FOSL1 include Pfeiffer Syndrome. Among its related pathways are MAPK Signaling: Oxidative Stress Pathway and IL27-mediated signaling events. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is FOSL2.

Gene Wiki entry for FOSL1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOSL1 Gene

Genomics for FOSL1 Gene

Regulatory Elements for FOSL1 Gene

Enhancers for FOSL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FOSL1 on UCSC Golden Path with GeneCards custom track

Promoters for FOSL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FOSL1 Gene

Chromosome:
11
Start:
65,892,049 bp from pter
End:
65,900,573 bp from pter
Size:
8,525 bases
Orientation:
Minus strand

Genomic View for FOSL1 Gene

Genes around FOSL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOSL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOSL1 Gene

Proteins for FOSL1 Gene

  • Protein details for FOSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15407-FOSL1_HUMAN
    Recommended name:
    Fos-related antigen 1
    Protein Accession:
    P15407
    Secondary Accessions:
    • B4DR11
    • Q6FG51

    Protein attributes for FOSL1 Gene

    Size:
    271 amino acids
    Molecular mass:
    29413 Da
    Quaternary structure:
    • Heterodimer.

    Alternative splice isoforms for FOSL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOSL1 Gene

Post-translational modifications for FOSL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FOSL1 Gene

Domains & Families for FOSL1 Gene

Protein Domains for FOSL1 Gene

Graphical View of Domain Structure for InterPro Entry

P15407

UniProtKB/Swiss-Prot:

FOSL1_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. Fos subfamily.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. Fos subfamily.
genes like me logo Genes that share domains with FOSL1: view

Function for FOSL1 Gene

Molecular function for FOSL1 Gene

GENATLAS Biochemistry:
fos antigen-like 1,target molecule for retinoid action in pancreatic carcinoma cell line Dan-G

Gene Ontology (GO) - Molecular Function for FOSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA,IDA 21673316
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding IBA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 10918580
genes like me logo Genes that share ontologies with FOSL1: view
genes like me logo Genes that share phenotypes with FOSL1: view

Animal Models for FOSL1 Gene

MGI Knock Outs for FOSL1:

Animal Model Products

CRISPR Products

Transcription Factor Targets for FOSL1 Gene

Selected GeneGlobe predicted Target genes for FOSL1
Targeted motifs for FOSL1 Gene
HOMER Transcription Factor Regulatory Elements motif FOSL1
  • Consensus sequence: NNATGASTCATH Submotif: canonical Cell Type: BT549 GEO ID: GSE46166

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FOSL1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for FOSL1 Gene

Localization for FOSL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOSL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOSL1 Gene COMPARTMENTS Subcellular localization image for FOSL1 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for FOSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA --
GO:0005829 cytosol IEA --
GO:0042734 presynaptic membrane IEA --
GO:0043005 neuron projection IEA --
GO:0043231 intracellular membrane-bounded organelle IEA --
genes like me logo Genes that share ontologies with FOSL1: view

Pathways & Interactions for FOSL1 Gene

genes like me logo Genes that share pathways with FOSL1: view

Gene Ontology (GO) - Biological Process for FOSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 10918580
GO:0006366 transcription from RNA polymerase II promoter TAS 2107490
GO:0006935 chemotaxis TAS 10918580
GO:0006968 cellular defense response TAS 10918580
genes like me logo Genes that share ontologies with FOSL1: view

No data available for SIGNOR curated interactions for FOSL1 Gene

Drugs & Compounds for FOSL1 Gene

(11) Drugs for FOSL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for FOSL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FOSL1: view

Transcripts for FOSL1 Gene

Unigene Clusters for FOSL1 Gene

FOS-like antigen 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FOSL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOSL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1:
SP2:
SP3: - -
SP4: -
SP5: -
SP6: - -

Relevant External Links for FOSL1 Gene

GeneLoc Exon Structure for
FOSL1
ECgene alternative splicing isoforms for
FOSL1

Expression for FOSL1 Gene

mRNA expression in normal human tissues for FOSL1 Gene

mRNA differential expression in normal tissues according to GTEx for FOSL1 Gene

This gene is overexpressed in Minor Salivary Gland (x5.4), Esophagus - Mucosa (x4.5), and Adipose - Visceral (Omentum) (x4.2).

Protein differential expression in normal tissues from HIPED for FOSL1 Gene

This gene is overexpressed in Cardia (35.6) and Retina (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FOSL1 Gene



NURSA nuclear receptor signaling pathways regulating expression of FOSL1 Gene:

FOSL1

SOURCE GeneReport for Unigene cluster for FOSL1 Gene:

Hs.283565
genes like me logo Genes that share expression patterns with FOSL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FOSL1 Gene

Orthologs for FOSL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOSL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOSL1 34
  • 88.18 (n)
  • 93.66 (a)
FOSL1 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOSL1 34
  • 88.56 (n)
  • 91.42 (a)
FOSL1 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fosl1 34
  • 83.27 (n)
  • 90.71 (a)
Fosl1 16
Fosl1 35
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOSL1 34
  • 99.51 (n)
  • 99.26 (a)
FOSL1 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fosl1 34
  • 81.3 (n)
  • 87.82 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia FOSL1 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOSL1 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fosl1 34
  • 60.36 (n)
  • 64.18 (a)
zebrafish
(Danio rerio)
Actinopterygii fosl1a 34
  • 60.43 (n)
  • 62.98 (a)
fosl1a 35
  • 44 (a)
OneToMany
fosl1b 35
  • 58 (a)
OneToMany
fosl1b 35
  • 28 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta kay 35
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 20 (a)
OneToMany
Species where no ortholog for FOSL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOSL1 Gene

ENSEMBL:
Gene Tree for FOSL1 (if available)
TreeFam:
Gene Tree for FOSL1 (if available)

Paralogs for FOSL1 Gene

Paralogs for FOSL1 Gene

(3) SIMAP similar genes for FOSL1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for FOSL1 Gene

genes like me logo Genes that share paralogs with FOSL1: view

Variants for FOSL1 Gene

Sequence variations from dbSNP and Humsavar for FOSL1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1058068 -- 65,900,325(-) GACTT(C/T)GGGGA intron-variant, reference, synonymous-codon
rs1143711 -- 65,902,362(+) gtgtg(A/T)gagag upstream-variant-2KB
rs1151520 -- 65,892,342(+) TCTCA(A/G)AGCTG nc-transcript-variant, utr-variant-3-prime
rs1151523 -- 65,897,729(+) GCACC(C/T)GTTTG intron-variant
rs7950010 -- 65,900,606(+) CCCGG(A/C)GGCTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FOSL1 Gene

Variant ID Type Subtype PubMed ID
esv2759834 CNV gain 17122850
nsv1159905 CNV duplication 26073780
nsv39194 CNV deletion 16902084
nsv555215 CNV loss 21841781
nsv832191 CNV loss 17160897
nsv951019 CNV deletion 24416366

Variation tolerance for FOSL1 Gene

Residual Variation Intolerance Score: 46.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOSL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOSL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOSL1 Gene

Disorders for FOSL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FOSL1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
pfeiffer syndrome
  • craniofacial-skeletal-dermatologic dysplasia
- elite association - COSMIC cancer census association via MalaCards
Search FOSL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FOSL1

Genetic Association Database (GAD)
FOSL1
Human Genome Epidemiology (HuGE) Navigator
FOSL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOSL1
genes like me logo Genes that share disorders with FOSL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOSL1 Gene

Publications for FOSL1 Gene

  1. Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. (PMID: 2107490) Matsui M. … Ishizaki R. (Oncogene 1990) 2 3 4 22 65
  2. AP-1 (Fra-1/c-Jun)-mediated induction of expression of matrix metalloproteinase-2 is required for 15S-hydroxyeicosatetraenoic acid-induced angiogenesis. (PMID: 20353950) Singh N.K. … Rao G.N. (J. Biol. Chem. 2010) 3 22 65
  3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 65
  4. Genetical genomic determinants of alcohol consumption in rats and humans. (PMID: 19874574) Tabakoff B. … Hoffman P.L. (BMC Biol. 2009) 3 46 65
  5. Fra-1 and Stat3 synergistically regulate activation of human MMP-9 gene. (PMID: 17572495) Song Y. … Guo N. (Mol. Immunol. 2008) 3 22 65

Products for FOSL1 Gene

Sources for FOSL1 Gene

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