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FOSL1 Gene

protein-coding   GIFtS: 65
GCID: GC11M065659

FOS-Like Antigen 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FOS-Like Antigen 11 2     Fos-Related Antigen 12
FRA12 3     fra-12
FRA2     FRA-13
FOS-Like Antigen-12     

External Ids:    HGNC: 137181   Entrez Gene: 80612   Ensembl: ENSG000001755927   OMIM: 1365155   UniProtKB: P154073   

Export aliases for FOSL1 gene to outside databases

Previous GC identifers: GC11M068193 GC11M067341 GC11M065909 GC11M065435 GC11M065416 GC11M061986


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FOSL1 Gene:
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins
that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As
such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and
transformation. (provided by RefSeq, Jul 2008)

GeneCards Summary for FOSL1 Gene:
FOSL1 (FOS-like antigen 1) is a protein-coding gene. Diseases associated with FOSL1 include estrogen-receptor negative breast cancer, and human t-cell leukemia virus type 1. GO annotations related to this gene include RNA polymerase II regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOSB.

Gene Wiki entry for FOSL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FOSL1 gene promoter:
         TBP   STAT1   p53   ATF-2   p300   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOSL1 promoter sequence
   Search Chromatin IP Primers for FOSL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOSL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

FOSL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOSL1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M065659:  view genomic region     (about GC identifiers)

Start:
65,659,520 bp from pter      End:
65,668,044 bp from pter
Size:
8,525 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FOSL1_HUMAN, P15407 (See protein sequence)
Recommended Name: Fos-related antigen 1  
Size: 271 amino acids; 29413 Da
Subunit: Heterodimer (By similarity)
Secondary accessions: Q6FG51

Explore the universe of human proteins at neXtProt for FOSL1: NX_P15407

Explore proteomics data for FOSL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FOSL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005429.1  
    ENSEMBL proteins: 
     ENSP00000393302   ENSP00000310170   ENSP00000436276   ENSP00000431594   ENSP00000434350  

    FOSL1 Human Recombinant Protein Products:

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    Novus Biologicals FOSL1 Protein
    Novus Biologicals FOSL1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FOSL1

    FOSL1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FOSL1 (FRA-1)
    Cell Signaling Technology (CST) Antibodies for FOSL1  (FRA1)
    OriGene Antibodies for FOSL1
    OriGene Custom Antibody Services for FOSL1
    Novus Biologicals FOSL1 Antibodies
    Abcam antibodies for FOSL1
    Cloud-Clone Corp. Antibodies for FOSL1
    ThermoFisher Antibodies for FOSL1
    LSBio Antibodies in human, mouse, rat for FOSL1

    FOSL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FOSL1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FOSL1
    Cell Signaling Technology (CST) Sandwich ELISA Kits for FOSL1 (FRA1)
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FOSL1
    Cloud-Clone Corp. CLIAs for FOSL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    2 InterPro protein domains:
     IPR004827 bZIP
     IPR000837 Leuzip_Fos

    Graphical View of Domain Structure for InterPro Entry P15407

    ProtoNet protein and cluster: P15407

    2 Blocks protein domains:
    IPB000837 Fos transforming protein signature
    IPB011616 bZIP transcription factor


    UniProtKB/Swiss-Prot: FOSL1_HUMAN, P15407
    Similarity: Belongs to the bZIP family. Fos subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    FOSL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for FOSL1:
    fos antigen-like 1,target molecule for retinoid action in pancreatic carcinoma cell line Dan-G

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI16189514
    GO:0043565sequence-specific DNA binding ----
         
    FOSL1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for FOSL1:
     Decreased cell number and incr  Increased HPV18 LCR reporter a  Synthetic lethal with imatinib 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Fosl1):
     cardiovascular system  embryogenesis  growth/size/body  hematopoietic system  mortality/aging 
     normal  skeleton 

    FOSL1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FOSL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FOSL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FOSL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FOSL1

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for FOSL1 (see all 138):
    ABCA9,  ABHD6,  ACTR2,  ADAM19,  AIG1,  ANKRD10,  ARHGAP23,  ASPH,  B3GALT1,  C1orf35

    miRNA
    Products:
        
    miRTarBase miRNAs that target FOSL1:
    hsa-mir-34a-5p (MIRT006546)

    Block miRNA regulation of human, mouse, rat FOSL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FOSL1 (see all 34):
    hsa-miR-15a hsa-miR-503 hsa-miR-301a hsa-miR-449a hsa-miR-4267 hsa-miR-424 hsa-miR-29a* hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidFOSL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FOSL1
    Predesigned siRNA for gene silencing in human, mouse, rat FOSL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FOSL1

    Clone
    Products:
         
    OriGene clones in human, mouse for FOSL1 (see all 5)
    OriGene ORF clones in mouse, rat for FOSL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FOSL1 (NM_005438)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOSL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOSL1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FOSL1
    Browse ESI BIO Cell Lines and PureStem Progenitors for FOSL1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOSL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FOSL1_HUMAN, P15407: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion3
    cytoskeleton2
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol IEA--
    GO:0042734presynaptic membrane IEA--
    GO:0043005neuron projection IEA--
    GO:0043231intracellular membrane-bounded organelle ----

    FOSL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FOSL1 About   (see all 30)  
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    NOD-like Receptor Signaling Pathways0.58
    Immune response IL 1 signaling pathway0.42
    Inflammasome Activation Pathways0.51
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    IL-1 Family Signaling Pathways0.44
    2IL-17 Family Signaling Pathways
    IL-17 Family Signaling Pathways0.51
    Mucin expression in CF via IL 6, IL 17 signaling pathways0.48
    3Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55
    4Immune response IL 2 activation and signaling pathway
    Immune response IL 2 activation and signaling pathway0.41
    Immune response IL 3 activation and signaling pathway0.41
    5Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes0.38
    Calcium signaling in the CD4+ TCR pathway0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for FOSL1 (see all 10)
        Inflammasome Activation Pathways
    Adipocytokines & Insulin Signaling
    IL-17 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FOSL1 (see all 9)
        ERK5 Signaling
    iNOS Signaling
    SMAD Signaling Network
    Ceramide Pathway
    ILK Signaling

    1 Cell Signaling Technology (CST) Pathway for FOSL1
        MAP Kinase Signaling

    Selected GeneGo (Thomson Reuters) Pathways for FOSL1 (see all 8)
        Transcription Role of VDR in regulation of genes involved in osteoporosis
    Immune response CD16 signaling in NK cells
    Mucin expression in CF via IL-6, IL-17 signaling pathways
    Immune response IL-2 activation and signaling pathway
    Mucin expression in CF via TLRs, EGFR signaling pathways

    Selected BioSystems Pathways for FOSL1 (see all 9)
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    DNA damage response (only ATM dependent)
    Corticotropin-releasing hormone
    Calcium signaling in the CD4+ TCR pathway

    1 PharmGKB Pathway for FOSL1
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    3 Kegg Pathways  (Kegg details for FOSL1):
        Wnt signaling pathway
    Osteoclast differentiation
    HTLV-I infection


    FOSL1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FOSL1 (see all 7): 
              Stem Cell Transcription Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              WNT Signaling Pathway in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FOSL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FOSL1 (P154071, 2, 3 ENSP000003101704) via UniProtKB, MINT, STRING, and/or I2D (see all 76)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALCOCO1Q9P1Z22, 3, ENSP000002620594MINT-68294 I2D: score=5 STRING: ENSP00000262059
    LDOC1O957511, 2, 3, ENSP000003595574EBI-744510,EBI-740738 MINT-66527 I2D: score=5 STRING: ENSP00000359557
    JUNBP172753, ENSP000003033154I2D: score=6 STRING: ENSP00000303315
    JUNP054123, ENSP000003602664I2D: score=4 STRING: ENSP00000360266
    JUNDP175353, ENSP000002528184I2D: score=1 STRING: ENSP00000252818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS10918580
    GO:0006366transcription from RNA polymerase II promoter TAS2107490
    GO:0006935chemotaxis TAS10918580

    FOSL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FOSL1

    Selected Novoseek inferred chemical compound relationships for FOSL1 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    12-o-tetradecanoylphorbol 13-acetate 49.9 11 13679379 (5), 8389757 (1), 7761434 (1), 17082637 (1) (see all 5)
    phorbol 30.5 1 9662339 (1)
    pdtc 29.8 1 8985358 (1)
    matrigel 27 2 15319566 (1), 15608675 (1)
    pd 98,059 26.1 2 10762717 (1), 15615716 (1)
    sb 203580 24.5 1 10762717 (1)
    okadaic acid 21.5 3 1851743 (1), 1316910 (1)
    leucine 21.2 5 19251936 (1), 7568884 (1), 16829632 (1), 18083929 (1)
    retinoid 17.6 4 10217407 (3)
    glycogen 13.8 1 19435822 (1)



    FOSL1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FOSL1 gene: 
    NM_005438.3  

    Unigene Cluster for FOSL1:

    FOS-like antigen 1
    Hs.283565  [show with all ESTs]
    Unigene Representative Sequence: NM_005438
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000448083 ENST00000312562(uc001ogg.1 uc010ros.1) ENST00000531493
    ENST00000532401 ENST00000534222
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FOSL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FOSL1 (see all 34):
    hsa-miR-15a hsa-miR-503 hsa-miR-301a hsa-miR-449a hsa-miR-4267 hsa-miR-424 hsa-miR-29a* hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidFOSL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FOSL1
    Predesigned siRNA for gene silencing in human, mouse, rat FOSL1
    Clone
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    OriGene clones in human, mouse for FOSL1 (see all 5)
    OriGene ORF clones in mouse, rat for FOSL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FOSL1 (NM_005438)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOSL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOSL1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FOSL1
    OriGene qSTAR qPCR primer pairs in human, mouse for FOSL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FOSL1
      QuantiTect SYBR Green Assays in human, mouse, rat FOSL1
      QuantiFast Probe-based Assays in human, mouse, rat FOSL1

    Additional mRNA sequence: 

    AK222902.1 AK293297.1 AK299050.1 AK313718.1 BC016648.1 CR542257.1 CR542278.1 S68214.1 
    X16707.1 

    10 DOTS entries:

    DT.448961  DT.100028987  DT.91974650  DT.100798399  DT.115680  DT.100798397  DT.100798398  DT.100798400 
    DT.212867  DT.97810916 

    Selected AceView cDNA sequences (see all 406):

    CB111644 CA426865 BF000185 BC016648 BM763039 CK823076 AI343355 AI921952 
    AW009355 CR608946 BQ426063 BF063390 AI275500 AI042234 BU623627 BI850734 
    BM559627 BE674859 BQ937004 AI417488 AI420017 CA454182 AI159767 AI085516 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FOSL1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
    SP1:                                                            
    SP2:                                                            
    SP3:                    -     -                                 
    SP4:                                -                           
    SP5:                          -                                 


    ECgene alternative splicing isoforms for FOSL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FOSL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCACACCCT
    FOSL1 Expression
    About this image

    FOSL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FOSL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.283565
        Pathway & Disease-focused RT2 Profiler PCR Arrays including FOSL1 (see all 7): 
              Stem Cell Transcription Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              WNT Signaling Pathway in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FOSL1
    OriGene qSTAR qPCR primer pairs in human, mouse for FOSL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FOSL1
    QuantiTect SYBR Green Assays in human, mouse, rat FOSL1
    QuantiFast Probe-based Assays in human, mouse, rat FOSL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOSL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FOSL1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fosl11 , 5 fos-like antigen 11, 5 83.27(n)1
    90.71(a)1
      19 (4.33 cM)5
    142831  NM_010235.21  NP_034365.11 
     54476985 
    lizard
    (Anolis carolinensis)
    Reptilia FOSL16
    FOS-like antigen 1
    57(a)
    1 ↔ 1
    GL344183.1(26663-32768)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fosl11 FOS-like antigen 1 60.36(n)
    64.18(a)
      100038288  XM_002939331.2  XP_002939377.2 
    zebrafish
    (Danio rerio)
    Actinopterygii fosl1a1 FOS-like antigen 1a 60.43(n)
    62.98(a)
      564241  NM_001161552.1  NP_001155024.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta kay6
    kayak
    11(a)
    1 → many
    3R(25592497-25619838)


    ENSEMBL Gene Tree for FOSL1 (if available)
    TreeFam Gene Tree for FOSL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FOSL1 gene
    FOSB2  FOS2  FOSL22  
    3 SIMAP similar genes for FOSL1 using alignment to 5 protein entries:     FOSL1_HUMAN (see all proteins):
    ATF3    FOSL2    FOSB

    FOSL1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FOSL1
    PGOHUM00000246070


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FOSL1 (see all 239)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs559043371,2
    C--65659778(+) GCTGTA/GGAGGC 1 -- ut310--------
    rs11515201,2
    C,F,A,H--65659813(+) TCTCAA/GAGCTG 1 -- ut3117Minor allele frequency- G:0.12MN EA NA NS WA 1626
    rs1829547941,2
    --65660104(+) TGGCAC/TAAATG 1 -- ut310--------
    rs557407241,2
    C--65660311(+) GGAGGA/GGACAT 1 -- ut310--------
    rs1421199791,2
    F--65660378(+) GTTGGA/GGAGCC 2 S syn11Minor allele frequency- G:0.00NA 4516
    rs1506152011,2
    F--65660502(+) GGGAGG/AGTGTG 2 /P /L mis11Minor allele frequency- A:0.00NA 4548
    rs2003262431,2
    --65660518(+) GAGTGC/TGGGGG 2 T A mis10--------
    rs1396754721,2
    C,F--65660584(+) AGGGCG/AGCAGG 2 /R /C mis12Minor allele frequency- A:0.00NA EU 5123
    rs1447600681,2
    C,F--65660600(+) GGTGGG/TCTGCT 2 R S mis11Minor allele frequency- T:0.00NA 4422
    rs1147878431,2
    C,F--65660648(+) CCTTCC/TGGGAT 2 P syn12Minor allele frequency- T:0.04WA NA 4650

    HapMap Linkage Disequilibrium report for FOSL1 (65659520 - 65668044 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for FOSL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv39194CNV Loss16902084
    nsv897764CNV Loss21882294
    nsv832191CNV Loss17160897
    dgv1185n71CNV Loss21882294
    nsv897736CNV Loss21882294
    dgv393e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing FOSL1:
    WNT Signaling
    SeqTarget long-range PCR primers for resequencing FOSL1
    DNA2.0 Custom Variant and Variant Library Synthesis for FOSL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 136515    OMIM disorders: --

    Selected diseases for FOSL1 (see all 42):    
    About MalaCards
    estrogen-receptor negative breast cancer    human t-cell leukemia virus type 1    osteosclerosis    interstitial lung disease
    glioblastoma multiforme    familial breast cancer    cervical cancer    cervicitis
    oral cancer    esophageal cancer    osteoporosis    oral squamous cell carcinoma
    t-cell leukemia    esophageal squamous cell carcinoma    pheochromocytoma    nasopharyngitis
    esophagitis    squamous cell carcinoma    breast cancer    pulmonary fibrosis

    1 disease from the University of Copenhagen DISEASES database for FOSL1:
    Cancer

    FOSL1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for FOSL1 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 44.7 1 11145887 (1)
    tumors 35 30 15514944 (3), 10502734 (2), 12209953 (1), 12692267 (1) (see all 19)
    neoplastic disease 32 2 17254320 (1), 14519134 (1)
    glioblastoma multiforme 31 5 18172271 (1), 15831677 (1)
    epithelial tumor 23.3 1 9819396 (1)
    colon carcinoma 22.3 1 18098284 (1)
    hnscc 18.7 2 16045542 (1)
    cancer 16.6 9 18606715 (3), 16784822 (2), 17371847 (1), 18288638 (1) (see all 5)
    lung tumor 15.8 1 18288638 (1)
    colon cancer 10.6 1 12209953 (1)

    Genetic Association Database (GAD): FOSL1
    Human Genome Epidemiology (HuGE) Navigator: FOSL1 (8 documents)

    Export disorders for FOSL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FOSL1 gene, integrated from 10 sources (see all 261):
    (articles sorted by number of sources associating them with FOSL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. (PubMed id 2107490)1, 2, 3, 9 Matsui M.... Ishizaki R. (Oncogene 1990)
    2. Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals. (PubMed id 8230424)1, 2, 9 Tsuchiya H.... Seiki M. (J. Virol. 1993)
    3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    4. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (BMC Biol. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. FRA-1 protein overexpression is a feature of hyperplastic and neoplastic breast disorders. (PubMed id 17254320)1, 9 Chiappetta G....Fusco A. (BMC Cancer 2007)
    7. Fra-1 governs cell migration via modulation of CD44 expression in human mesotheliomas. (PubMed id 18096084)1, 9 Ramos-Nino M.E....Mossman B.T. (Mol. Cancer 2007)
    8. Fos-related antigen 1 modulates malignant features of glioma cells. (PubMed id 15831677)1, 9 Debinski W. and Gibo D.M. (Mol. Cancer Res. 2005)
    9. Ubiquitin-independent proteasomal degradation of Fra-1 is antagonized by Erk1/2 pathway-mediated phosphorylation of a unique C-terminal destabilizer. (PubMed id 17371847)1, 9 Basbous J....Piechaczyk M. (Mol. Cell. Biol. 2007)
    10. Fra-1 and Stat3 synergistically regulate activation of human MMP-9 gene. (PubMed id 17572495)1, 9 Song Y....Guo N. (Mol. Immunol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8061 HGNC: 13718 AceView: FOSL1 Ensembl:ENSG00000175592 euGenes: HUgn8061
    ECgene: FOSL1 Kegg: 8061 H-InvDB: FOSL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FOSL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FOSL1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FOSL1 gene:
    Search GeneIP for patents involving FOSL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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