Aliases for FOSB Gene
External Ids for FOSB Gene
Previous GeneCards Identifiers for FOSB Gene
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for FOSB Gene
FOSB (FosB Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with FOSB include Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly and Short-Rib Thoracic Dysplasia 1 With Or Without Polydactyly. Among its related pathways are Toll-like receptor signaling pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is FOS.
UniProtKB/Swiss-Prot for FOSB Gene
FosB interacts with Jun proteins enhancing their DNA binding activity.