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Aliases for FOSB Gene

Aliases for FOSB Gene

  • FosB Proto-Oncogene, AP-1 Transcription Factor Subunit 2 3 5
  • FBJ Murine Osteosarcoma Viral Oncogene Homolog B 2 3
  • G0/G1 Switch Regulatory Protein 3 3 4
  • Activator Protein 1 2 3
  • G0S3 3 4
  • FosB Proto-Oncogene, AP-1 Trancription Factor Subunit 3
  • Oncogene FOS-B 2
  • Protein FosB 3
  • AP-1 3
  • GOS3 3
  • GOSB 3

External Ids for FOSB Gene

Previous GeneCards Identifiers for FOSB Gene

  • GC19P046615
  • GC19P046362
  • GC19P050647
  • GC19P050663
  • GC19P045971
  • GC19P042400

Summaries for FOSB Gene

Entrez Gene Summary for FOSB Gene

  • The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOSB Gene

FOSB (FosB Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with FOSB include Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly and Short-Rib Thoracic Dysplasia 1 With Or Without Polydactyly. Among its related pathways are Toll-like receptor signaling pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is FOS.

UniProtKB/Swiss-Prot for FOSB Gene

  • FosB interacts with Jun proteins enhancing their DNA binding activity.

Gene Wiki entry for FOSB Gene

Additional gene information for FOSB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOSB Gene

Genomics for FOSB Gene

GeneHancer (GH) Regulatory Elements for FOSB Gene

Promoters and enhancers for FOSB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I045466 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.1 1101 4.3 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B FOSB GC19P045469 ZNF180 CLASRP CCDC61 CD3EAP FBXO46 ENSG00000269148 ENSG00000268810 BLOC1S3
GH19I045453 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17.3 -12.8 -12800 4.2 CLOCK MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF766 FOS SP3 FOSB RELB ERCC1 CD3EAP VASP CLASRP GIPR BLOC1S3 MIR6088
GH19I045096 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.9 -366.6 -366598 9.7 PKNOX1 ATF1 FOXA2 ARID4B SIN3A FEZF1 GLI4 ZNF48 GLIS2 FOS GC19M045094 GEMIN7 MRPS15P2 FOSB ZNF296 PPP1R37 RELB CLASRP ZNF225 NKPD1
GH19I045442 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -24.0 -24035 3.7 YBX1 FEZF1 DMAP1 SLC30A9 ZNF143 SP3 MEF2D ZNF610 GLIS1 NBN ENSG00000268810 CD3EAP RELB ZNF180 PPP1R13L ERCC1 PPM1N RTN2 CLASRP FOSB
GH19I046295 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.3 +832.5 832546 9.4 PKNOX1 ZNF133 ARID4B SIN3A ZNF121 GLIS2 KLF7 SP3 RXRA SP5 HIF3A PPP5C ENSG00000269124 FOSB IGFL3 MYPOP IRF2BP1 CCDC8 DACT3 RNU6-924P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FOSB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FOSB gene promoter:

Genomic Locations for FOSB Gene

Genomic Locations for FOSB Gene
chr19:45,467,995-45,475,179
(GRCh38/hg38)
Size:
7,185 bases
Orientation:
Plus strand
chr19:45,971,253-45,978,437
(GRCh37/hg19)

Genomic View for FOSB Gene

Genes around FOSB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOSB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOSB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOSB Gene

Proteins for FOSB Gene

neXtProt entry for FOSB Gene

Post-translational modifications for FOSB Gene

No Post-translational modifications

No data available for DME Specific Peptides for FOSB Gene

Domains & Families for FOSB Gene

Gene Families for FOSB Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOSB Gene

Graphical View of Domain Structure for InterPro Entry

P53539

UniProtKB/Swiss-Prot:

FOSB_HUMAN :
  • Belongs to the bZIP family. Fos subfamily.
Family:
  • Belongs to the bZIP family. Fos subfamily.
genes like me logo Genes that share domains with FOSB: view

Function for FOSB Gene

Molecular function for FOSB Gene

GENATLAS Biochemistry:
murine FBJ osteosarcoma viral (v-fos) oncogen homolog B,ligand induced,immediate (primary) early response gene
UniProtKB/Swiss-Prot Function:
FosB interacts with Jun proteins enhancing their DNA binding activity.

Phenotypes From GWAS Catalog for FOSB Gene

Gene Ontology (GO) - Molecular Function for FOSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0003677 DNA binding TAS 1900040
GO:0003690 double-stranded DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with FOSB: view
genes like me logo Genes that share phenotypes with FOSB: view

Animal Models for FOSB Gene

MGI Knock Outs for FOSB:

Animal Model Products

miRNA for FOSB Gene

miRTarBase miRNAs that target FOSB

Transcription Factor Targets for FOSB Gene

Selected GeneGlobe predicted Target genes for FOSB

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for FOSB Gene

Localization for FOSB Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOSB Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOSB gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FOSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 22387553
GO:0005654 nucleoplasm IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with FOSB: view

Pathways & Interactions for FOSB Gene

genes like me logo Genes that share pathways with FOSB: view

SIGNOR curated interactions for FOSB Gene

Is activated by:

Gene Ontology (GO) - Biological Process for FOSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS 1900040
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006366 transcription by RNA polymerase II IEA --
GO:0007565 female pregnancy IEA --
genes like me logo Genes that share ontologies with FOSB: view

Drugs & Compounds for FOSB Gene

(8) Drugs for FOSB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for FOSB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FOSB: view

Transcripts for FOSB Gene

Unigene Clusters for FOSB Gene

FBJ murine osteosarcoma viral oncogene homolog B:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOSB Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6
SP1: - - -
SP2: -
SP3: - - - -
SP4: - -
SP5:

Relevant External Links for FOSB Gene

GeneLoc Exon Structure for
FOSB
ECgene alternative splicing isoforms for
FOSB

Expression for FOSB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOSB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOSB Gene

This gene is overexpressed in Fallopian Tube (x12.9) and Adipose - Visceral (Omentum) (x8.9).

Protein differential expression in normal tissues from HIPED for FOSB Gene

This gene is overexpressed in Adrenal (57.9) and Placenta (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FOSB Gene



Protein tissue co-expression partners for FOSB Gene

NURSA nuclear receptor signaling pathways regulating expression of FOSB Gene:

FOSB

SOURCE GeneReport for Unigene cluster for FOSB Gene:

Hs.590958

Evidence on tissue expression from TISSUES for FOSB Gene

  • Nervous system(4.8)
  • Blood(4.5)
  • Thyroid gland(4.4)
  • Lung(3)
  • Intestine(2.6)
  • Adrenal gland(2.5)
  • Gall bladder(2.3)
  • Bone marrow(2.2)
  • Muscle(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with FOSB: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOSB Gene

Orthologs for FOSB Gene

This gene was present in the common ancestor of animals.

Orthologs for FOSB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOSB 33 34
  • 95.76 (n)
dog
(Canis familiaris)
Mammalia FOSB 33 34
  • 94.58 (n)
mouse
(Mus musculus)
Mammalia Fosb 33 16 34
  • 90.73 (n)
rat
(Rattus norvegicus)
Mammalia Fosb 33
  • 90.34 (n)
oppossum
(Monodelphis domestica)
Mammalia FOSB 34
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOSB 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490871 33
  • 57.53 (n)
zebrafish
(Danio rerio)
Actinopterygii fosb 33 34
  • 70.51 (n)
fruit fly
(Drosophila melanogaster)
Insecta kay 34
  • 12 (a)
OneToMany
Species where no ortholog for FOSB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOSB Gene

ENSEMBL:
Gene Tree for FOSB (if available)
TreeFam:
Gene Tree for FOSB (if available)

Paralogs for FOSB Gene

Variants for FOSB Gene

Sequence variations from dbSNP and Humsavar for FOSB Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000056837 -- 45,472,387(+) A/G intron_variant
rs1000394319 -- 45,475,348(+) G/T downstream_transcript_variant
rs1000405841 -- 45,475,563(+) A/G downstream_transcript_variant
rs1001139911 -- 45,466,044(+) C/T upstream_transcript_variant
rs1001145355 -- 45,467,579(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FOSB Gene

Variant ID Type Subtype PubMed ID
nsv428365 CNV gain+loss 18775914
nsv833846 CNV loss 17160897
nsv833848 CNV loss 17160897

Variation tolerance for FOSB Gene

Residual Variation Intolerance Score: 23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOSB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOSB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOSB Gene

Disorders for FOSB Gene

MalaCards: The human disease database

(5) MalaCards diseases for FOSB Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search FOSB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FOSB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FOSB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOSB Gene

Publications for FOSB Gene

  1. Sequence analysis and expression in cultured lymphocytes of the human FOSB gene (G0S3). (PMID: 8985116) Heximer SP … Forsdyke DR (DNA and cell biology 1996) 3 4 22 58
  2. Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3. (PMID: 1301997) Martin-Gallardo A … Liu LI (Nature genetics 1992) 2 3 4 58
  3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges LM … MrOS Research Group (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009) 3 44 58
  4. Regulation of megakaryocytic differentiation of K562 cells by FosB, a member of the Fos family of AP-1 transcription factors. (PMID: 19381435) Limb JK … Kim J (Cellular and molecular life sciences : CMLS 2009) 3 22 58
  5. Identification of immunohistochemical prognostic markers for survival after resection of pulmonary metastases from colorectal carcinoma. (PMID: 19795327) Pfannschmidt J … Herpel E (The Thoracic and cardiovascular surgeon 2009) 3 22 58

Products for FOSB Gene

Sources for FOSB Gene

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