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FOSB Gene

protein-coding   GIFtS: 65
GCID: GC19P045971

FBJ Murine Osteosarcoma Viral Oncogene Homolog B

  See FOSB-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FBJ Murine Osteosarcoma Viral Oncogene Homolog B1 2     AP-12
Activator Protein 11 2     GOS32
G0S32 3     GOSB2
G0/G1 Switch Regulatory Protein 32 3     Protein FosB2
Oncogene FOS-B1     

External Ids:    HGNC: 37971   Entrez Gene: 23542   Ensembl: ENSG000001257407   OMIM: 1647725   UniProtKB: P535393   

Export aliases for FOSB gene to outside databases

Previous GC identifers: GC19P046615 GC19P046362 GC19P050647 GC19P050663 GC19P042400


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FOSB Gene:
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins
that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As
such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and
transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for FOSB Gene:
FOSB (FBJ murine osteosarcoma viral oncogene homolog B) is a protein-coding gene. Diseases associated with FOSB include osteosarcoma. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOSL1.

UniProtKB/Swiss-Prot: FOSB_HUMAN, P53539
Function: FosB interacts with Jun proteins enhancing their DNA binding activity

Gene Wiki entry for FOSB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FOSB gene promoter:
         Max   CREB   deltaCREB   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOSB promoter sequence
   Search Chromatin IP Primers for FOSB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOSB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.3

FOSB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOSB gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P045971:  view genomic region     (about GC identifiers)

Start:
45,971,253 bp from pter      End:
45,978,437 bp from pter
Size:
7,185 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FOSB_HUMAN, P53539 (See protein sequence)
Recommended Name: Protein fosB  
Size: 338 amino acids; 35928 Da
Subunit: Heterodimer (By similarity)
Secondary accessions: A8K9K5 A8VJE1 E9PHJ3
Alternative splicing: 2 isoforms:  P53539-1   P53539-2   

Explore the universe of human proteins at neXtProt for FOSB: NX_P53539

Explore proteomics data for FOSB at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FOSB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001107643.1  NP_006723.2  

    ENSEMBL proteins: 
     ENSP00000467497   ENSP00000407207   ENSP00000245919   ENSP00000466530   ENSP00000414177  
     ENSP00000465068   ENSP00000465552   ENSP00000468482   ENSP00000468207   ENSP00000465528  

    FOSB Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for FOSB
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FOSB
    GenScript Custom Purified and Recombinant Proteins Services for FOSB
    Novus Biologicals FOSB Proteins
    Novus Biologicals FOSB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for FOSB
    Cloud-Clone Corp. Proteins for FOSB

     
    Search eBioscience for Proteins for FOSB 

     
    antibodies-online proteins for FOSB (16 products) 

     
    antibodies-online peptides for FOSB

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    antibodies-online antibodies for FOSB (66 products) 

    FOSB Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for FOSB
    Cloud-Clone Corp. CLIAs for FOSB
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    antibodies-online kits for FOSB (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    2 InterPro protein domains:
     IPR004827 bZIP
     IPR000837 Leuzip_Fos

    Graphical View of Domain Structure for InterPro Entry P53539

    ProtoNet protein and cluster: P53539

    1 Blocks protein domain: IPB000837 Fos transforming protein signature

    UniProtKB/Swiss-Prot: FOSB_HUMAN, P53539
    Similarity: Belongs to the bZIP family. Fos subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    Find genes that share domains with FOSB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOSB_HUMAN, P53539
    Function: FosB interacts with Jun proteins enhancing their DNA binding activity

         Genatlas biochemistry entry for FOSB:
    murine FBJ osteosarcoma viral (v-fos) oncogen homolog B,ligand induced,immediate (primary) early response gene

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS1900040
    GO:0003690double-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008134transcription factor binding TAS1900040
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with FOSB           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FOSB:
     High actin ratio cells 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fosb):
     behavior/neurological  growth/size/body  nervous system 

    Find genes that share phenotypes with FOSB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FOSB: Fosbtm1Brv Fosbtm1Meg

       genOway: Develop your customized and physiologically relevant rodent model for FOSB

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for FOSB (see all 2409):
    A2ML1,  A4GALT,  AAA1,  AAAS,  AATF,  ABCA1,  ABCA12,  ABCA9,  ABCB1,  ABCB6

    miRNA
    Products:
        
    miRTarBase miRNAs that target FOSB:
    hsa-mir-224-5p (MIRT003234)

    Block miRNA regulation of human, mouse, rat FOSB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FOSB (see all 52):
    hsa-miR-2052 hsa-miR-19b-2* hsa-miR-513a-5p hsa-miR-128 hsa-miR-374a hsa-miR-766 hsa-miR-449a hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidFOSB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FOSB
    Predesigned siRNA for gene silencing in human, mouse, rat FOSB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FOSB

    Clone
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    OriGene ORF clones in mouse, rat for FOSB
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    GenScript: all cDNA clones in your preferred vector (see all 2): FOSB (NM_006732)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOSB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOSB

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    Browse ESI BIO Cell Lines and PureStem Progenitors for FOSB 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOSB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FOSB_HUMAN, P53539: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with FOSB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FOSB About   (see all 25)  
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    NOD-like Receptor Signaling Pathways0.58
    Immune response IL 1 signaling pathway0.42
    Inflammasome Activation Pathways0.51
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    IL-1 Family Signaling Pathways0.44
    2IL-17 Family Signaling Pathways
    IL-17 Family Signaling Pathways0.51
    Mucin expression in CF via IL 6, IL 17 signaling pathways0.48
    3Amphetamine addiction
    Cocaine addiction0.44
    Amphetamine addiction0.44
    4Immune response IL 2 activation and signaling pathway
    Immune response IL 2 activation and signaling pathway0.41
    Immune response IL 3 activation and signaling pathway0.41
    5TCR Signaling (Qiagen)
    ITK and TCR Signaling0.54


    Find genes that share SuperPaths with FOSB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for FOSB (see all 10)
        Inflammasome Activation Pathways
    Adipocytokines & Insulin Signaling
    IL-17 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FOSB (see all 7)
        iNOS Signaling
    SMAD Signaling Network
    Ceramide Pathway
    ILK Signaling
    ITK and TCR Signaling

    3 Cell Signaling Technology (CST) Pathways for FOSB
        MAP Kinase Signaling
    Cell Cycle / Checkpoint Control
    Neuroscience

    Selected GeneGo (Thomson Reuters) Pathways for FOSB (see all 7)
        Mucin expression in CF via TLRs, EGFR signaling pathways
    Immune response IL-3 activation and signaling pathway
    Immune response CD16 signaling in NK cells
    Mucin expression in CF via IL-6, IL-17 signaling pathways
    Immune response IL-2 activation and signaling pathway

    2 BioSystems Pathways for FOSB
        TGF-beta Receptor Signaling Pathway
    Corticotropin-releasing hormone

    1 PharmGKB Pathway for FOSB
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    4 Kegg Pathways  (Kegg details for FOSB):
        Osteoclast differentiation
    Cocaine addiction
    Amphetamine addiction
    Alcoholism

        Pathway & Disease-focused RT2 Profiler PCR Array including FOSB: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FOSB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FOSB (P535393 ENSP000002459194) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNP054123, ENSP000003602664I2D: score=3 STRING: ENSP00000360266
    JUNBP172753, ENSP000003033154I2D: score=3 STRING: ENSP00000303315
    JUNDP175353, ENSP000002528184I2D: score=3 STRING: ENSP00000252818
    CREBBPQ927933, ENSP000002623674I2D: score=1 STRING: ENSP00000262367
    HDAC2Q927693, ENSP000003813314I2D: score=1 STRING: ENSP00000381331
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS1900040
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter IEA--
    GO:0007275multicellular organismal development ----
    GO:0007565female pregnancy IEA--

    Find genes that share ontologies with FOSB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FOSB

    Selected Novoseek inferred chemical compound relationships for FOSB gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anisomycin 44.2 2 9528756 (1)
    12-o-tetradecanoylphorbol 13-acetate 39.8 2 11751871 (1), 7931079 (1)
    leucine 34.9 2 7919342 (1), 15828020 (1)
    okadaic acid 34.8 6 9873060 (4), 8706012 (1)
    phorbol 31.4 1 7671329 (1)
    oligonucleotide 20.8 1 11751871 (1)
    matrigel 19.3 1 15319566 (1)
    kainate 11.7 1 7520539 (1)
    carbachol 10.7 5 9523591 (4), 1328861 (1)
    calcium 0 1 9523591 (1)



    Find genes that share compounds with FOSB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FOSB gene (2 alternative transcripts): 
    NM_001114171.1  NM_006732.2  

    Unigene Cluster for FOSB:

    FBJ murine osteosarcoma viral oncogene homolog B
    Hs.590958  [show with all ESTs]
    Unigene Representative Sequence: BC036724
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000585836 ENST00000417353(uc010ekd.1 uc010eke.3 uc002pby.4)
    ENST00000353609(uc002pbw.3 uc010eka.1 uc010ekb.1 uc002pbx.4 uc010ekf.3 uc002pca.4)
    ENST00000591858 ENST00000443841(uc010ekc.1 uc010ekg.3) ENST00000590335
    ENST00000592436 ENST00000592811 ENST00000586113 ENST00000586615 ENST00000589593
    ENST00000587358
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    Selected qRT-PCR Assays for microRNAs that regulate FOSB (see all 52):
    hsa-miR-2052 hsa-miR-19b-2* hsa-miR-513a-5p hsa-miR-128 hsa-miR-374a hsa-miR-766 hsa-miR-449a hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidFOSB 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): FOSB (NM_006732)
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      QuantiTect SYBR Green Assays in human, mouse, rat FOSB
      QuantiFast Probe-based Assays in human, mouse, rat FOSB

    Additional mRNA sequence: 

    AF432216.1 AK097324.1 AK225070.1 AK292720.1 BC036724.1 BC040197.1 BC051767.1 BC063042.1 
    BC127825.1 BX538117.1 CR542101.1 D16366.1 EU178109.1 EU178110.1 EU178111.1 EU178112.1 
    EU178113.1 EU178114.1 EU178115.1 EU178116.1 L49169.1 

    22 DOTS entries:

    DT.91704152  DT.40245732  DT.99937901  DT.448257  DT.121483522  DT.97769742  DT.100738687  DT.92461989 
    DT.91698465  DT.100783281  DT.121483409  DT.92461968  DT.121483503  DT.121483419  DT.121483506  DT.91659175 
    DT.92026343  DT.95254289  DT.97766554  DT.95168169  DT.95168170  DT.97814403 

    Selected AceView cDNA sequences (see all 327):

    F05827 BF055464 BF881140 AV645429 AA235570 BQ876665 BU146670 AV719542 
    AJ346436 AU118031 AA296039 CA848309 AU141406 BQ181364 CA775066 AK097324 
    AI744962 F02073 AA019321 BQ030102 CA312265 BF109779 AA664063 BX538117 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FOSB    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6
    SP1:              -     -           -                     
    SP2:                                -                     
    SP3:              -     -           -     -               
    SP4:                    -           -                     
    SP5:                                                      


    ECgene alternative splicing isoforms for FOSB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FOSB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTACTTGT
    FOSB Expression
    About this image


    FOSB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Pre-Granulosa Cells Primordial Follicle
             Secondary follicles
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Inner Cell Mass (Early Embryonic Tissues)
             C2a
     
     Bone (Muscoskeletal System)
             Bone Marrow
    FOSB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FOSB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.590958
        Pathway & Disease-focused RT2 Profiler PCR Array including FOSB: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat FOSB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOSB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FOSB gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fosb1 , 5 FBJ osteosarcoma oncogene B1, 5 90.73(n)1
    95.86(a)1
      7 (9.56 cM)5
    142821  NM_008036.21  NP_032062.11 
     193027215 
    lizard
    (Anolis carolinensis)
    Reptilia FOSB6
    FBJ murine osteosarcoma viral oncogene homolog B
    64(a)
    1 ↔ 1
    AAWZ02036043(28933-31999)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004908711 protein fosB-like 57.53(n)
    57.04(a)
      100490871  XM_002932635.2  XP_002932681.2 
    zebrafish
    (Danio rerio)
    Actinopterygii fosb1 FBJ murine osteosarcoma viral oncogene homolog B 70.51(n)
    80.77(a)
      492346  NM_001007312.1  NP_001007313.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta kay6
    kayak
    12(a)
    1 → many
    3R(25592497-25619838)


    ENSEMBL Gene Tree for FOSB (if available)
    TreeFam Gene Tree for FOSB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for FOSB gene
    FOSL12  FOS2  FOSL22  
    6 SIMAP similar genes for FOSB using alignment to 18 protein entries:     FOSB_HUMAN (see all proteins):
    ATF3    JDP2    BATF    FOS    FOSL2    FOSL1

    Find genes that share paralogs with FOSB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for FOSB (see all 225)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409745391,2
    C--42399035(+) ACCTGA/TAATCC 2 -- us2k10--------
    rs1913286231,2
    --42399101(+) GCAGTG/TAGCCG 2 -- us2k10--------
    rs129815571,2
    C,F--42399115(+) ttgtgC/Gcactg 2 -- us2k16Minor allele frequency- G:0.42NA WA 12
    rs104095881,2
    C,A--42399166(+) AAAAAA/CAAAAA 2 -- us2k1 trp30--------
    rs718624551,2
    C--42399168(+) AAAAA-/AC/C  
            
    AAAAA
    2 -- us2k10--------
    rs1142500731,2
    C,F--42399216(+) CTCAGG/ATAGTC 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs104098411,2
    C,H--42399280(+) AGGAGT/ATTGTA 2 -- us2k1 trp318Minor allele frequency- A:0.00NS EA NA WA CSA 594
    rs283812321,2
    C,F--42399338(+) ATCTCG/AACACT 2 -- us2k15Minor allele frequency- A:0.00NS 180
    rs1838645751,2
    --42399400(+) GACCAA/GTATGG 2 -- us2k10--------
    rs1458946461,2
    --42399430(+) AACATA/GTAAAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for FOSB (45971253 - 45978437 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FOSB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833848CNV Loss17160897
    nsv912154CNV Loss21882294
    nsv833846CNV Loss17160897
    nsv428365CNV Gain+Loss18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FOSB
    DNA2.0 Custom Variant and Variant Library Synthesis for FOSB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164772    OMIM disorders: --

    1 disease for FOSB:    
    About MalaCards
    osteosarcoma

    1 disease from the University of Copenhagen DISEASES database for FOSB:
    Parkinson's disease

    Find genes that share disorders with FOSB           About GenesLikeMe

    6 Novoseek inferred disease relationships for FOSB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 1.85 12 10502734 (4), 19795327 (1), 15514944 (1), 9528756 (1) (see all 6)
    necrosis 0 1 9528756 (1)
    breast cancer 0 2 10918184 (1), 10502734 (1)
    nsclc 0 1 9662339 (1)
    carcinoma 0 1 15319566 (1)
    cancer 0 1 19653276 (1)

    Genetic Association Database (GAD): FOSB
    Human Genome Epidemiology (HuGE) Navigator: FOSB (6 documents)

    Export disorders for FOSB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for FOSB gene, integrated from 10 sources (see all 128):
    (articles sorted by number of sources associating them with FOSB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3. (PubMed id 1301997)1, 2, 3 Martin-Gallardo A.... Venter J.C. (Nat. Genet. 1992)
    2. Sequence analysis and expression in cultured lymphocytes of the human FOSB gene (G0S3). (PubMed id 8985116)1, 2, 9 Heximer S.P.... Forsdyke D.R. (DNA Cell Biol. 1996)
    3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    4. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    5. Genes controlling affiliative behavior as candidate genes for autism. (PubMed id 18207134)1, 4 Yrigollen C.M....Grigorenko E.L. (Biol. Psychiatry 2008)
    6. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Regulation of megakaryocytic differentiation of K562 cells by FosB, a member of the Fos family of AP-1 transcription factors. (PubMed id 19381435)1, 9 Limb J.K....Kim J. (Cell. Mol. Life Sci. 2009)
    9. A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity. (PubMed id 1900040)1, 9 Nakabeppu Y. and Nathans D. (Cell 1991)
    10. An unexpected role for FosB in activation-induced cell death of T cells. (PubMed id 12618758)1, 9 Baumann S....Kirchhoff S. (Oncogene 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 2354 HGNC: 3797 AceView: FOSB Ensembl:ENSG00000125740 euGenes: HUgn2354
    ECgene: FOSB Kegg: 2354 H-InvDB: FOSB

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FOSB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FOSB Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fosb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FOSB gene:
    Search GeneIP for patents involving FOSB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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