Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FOSB Gene

protein-coding GIFtS: 64
GCID: GC19P045971

FBJ murine osteosarcoma viral oncogene homolog B

Explore 24 diseases affiliated with
FOSB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
FBJ Murine Osteosarcoma Viral Oncogene Homolog B¹ ²		G0/G1 Switch Regulatory Protein 3² ³
G0S3¹ ² ³		DKFZp686C0818¹
AP-1¹ ²		MGC42291¹
GOS3¹ ²		Activator Protein 1²
GOSB¹ ²		Protein FosB²

External Ids:	HGNC: 3797¹	Entrez Gene: 2354²	Ensembl: ENSG00000125740⁷	OMIM: 164772⁵	UniProtKB: P53539³

Export aliases for FOSB gene to outside databases

Previous GC identifers: GC19P046615 GC19P046362 GC19P050647 GC19P050663 GC19P042400

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FOSB:

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that

can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS

proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively

spliced transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FOSB_HUMAN, P53539

Function: FosB interacts with Jun proteins enhancing their DNA binding activity

Gene Wiki entry for FOSB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FOSB gene promoter:
Max CREB deltaCREB c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FOSB promoter sequence

Search SABiosciences Chromatin IP Primers for FOSB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOSB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.3

FOSB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOSB gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P045971: view genomic region (about GC identifiers)

Start:	45,971,253 bp from pter	End:	45,978,437 bp from pter
Size:	7,185 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FOSB_HUMAN, P53539 (See protein sequence)

Recommended Name: Protein fosB

Size: 338 amino acids; 35928 Da

Subunit: Heterodimer (By similarity)

Subcellular location: Nucleus

Secondary accessions: A8K9K5 A8VJE1 E9PHJ3

Alternative splicing: 2 isoforms: P53539-1 P53539-2

Explore the universe of human proteins at neXtProt for FOSB: NX_P53539

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P53539

FOSB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001107643.1 NP_006723.2

ENSEMBL proteins:

ENSP00000467497 ENSP00000407207 ENSP00000245919 ENSP00000466530 ENSP00000414177

ENSP00000465068 ENSP00000465552 ENSP00000468482 ENSP00000468207 ENSP00000465528

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): FOSB OriGene Custom Protein Services for FOSB
	GenScript Custom Purified and Recombinant Proteins Services for FOSB
	Novus Biologicals FOSB Proteins Novus Biologicals FOSB Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for FOSB
	Uscn Proteins for FOSB

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

FOSB for ontologies About GeneDecksing

FOSB Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for FOSB (FosB/G0S3)
	Cell Signaling Technology (CST) Antibodies for FOSB
	Browse OriGene Antibodies OriGene Custom Antibody Services for FOSB
	GenScript Superior Antibodies for FOSB
	Novus Biologicals FOSB Antibodies
	Search for Antibodies for FOSB at Abcam
	Uscn Antibodies for FOSB
	ThermoFisher Antibody for FOSB

Assay Products for FOSB:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FOSB
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FOSB

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FOSB for domains About GeneDecksing

2 InterPro domains/families:

IPR004827 bZIP

IPR000837 Leuzip_Fos

Graphical View of Domain Structure for InterPro Entry P53539

ProtoNet protein and cluster: P53539

1 Blocks protein family: IPB000837 Fos transforming protein signature

UniProtKB/Swiss-Prot: FOSB_HUMAN, P53539

Similarity: Belongs to the bZIP family. Fos subfamily

Similarity: Contains 1 bZIP (basic-leucine zipper) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FOSB_HUMAN, P53539

Function: FosB interacts with Jun proteins enhancing their DNA binding activity

Genatlas biochemistry entry for FOSB:

murine FBJ osteosarcoma viral (v-fos) oncogen homolog B,ligand induced,immediate (primary) early response gene

		10/2460 SABiosciences Target genes for FOSB (see all 2460):
		A2ML1 A4GALT AAA1 AAAS AATF ABCA1 ABCA12 ABCA9 ABCB1 ABCB6

miRNA Products:		miRTarBase miRNAs that target FOSB: hsa-mir-224 (MIRT003234)

		OriGene 3'-UTR Clone (see all 2): FOSB Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOSB
		8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate FOSB (see all 52):
		hsa-miR-2052 hsa-miR-19b-2* hsa-miR-513a-5p hsa-miR-128 hsa-miR-374a hsa-miR-766 hsa-miR-449a hsa-miR-4267

		SwitchGear 3'UTR luciferase reporter plasmid: FOSB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOSB (see all 4) OriGene shRNA RFP: FOSB OriGene siRNA: FOSB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOSB

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for FOSB

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOSB (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOSB (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): FOSB (NM_006732)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOSB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOSB

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FOSB
		Search LifeMap BioReagents cell lines for FOSB

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOSB

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	TAS	1900040
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0008134	transcription factor binding	TAS	1900040
GO:0043565	sequence-specific DNA binding	IEA	--
GO:0046983	protein dimerization activity	--	--

FOSB for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for FOSB:

High actin ratio cells

Animal Models:
Mouse knock-outs for FOSB: Fosb^tm1Brv Fosb^tm1Meg
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fosb):

behavior/neurological

growth/size

nervous system

FOSB for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/22 super-pathways (see all 22) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune response_IL-2 activation and signaling pathway

	Immune response IL-2 activation and signaling pathway	1.00			Immune response_IL-3 activation and signaling pathway	0.41
	Immune response_IL-2 activation and signaling pathway	1.00			Immune response IL-3 activation and signaling pathway	0.41

Immune response_IL-1 signaling pathway

Immune response_IL-1 signaling pathway

1.00

Immune response IL-1 signaling pathway

0.98

Mucin expression in CF via IL-6, IL-17 signaling pathways

Mucin expression in CF via IL-6, IL-17 signaling pathways

1.00

Mucin expression in CF via TLRs, EGFR signaling pathways

0.41

Immune response CD16 signaling in NK cells

Immune response CD16 signaling in NK cells

1.00

Immune response_CD16 signaling in NK cells

0.99

Toll-like receptor signaling pathway

Toll-Like receptor Signaling Pathways

0.51

Inflammasome Activation Pathways

0.29

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for FOSB

	Immune response CD16 signaling in NK cells
	Immune response IL-3 activation and signaling pathway
	Immune response Oncostatin M signaling via MAPK in human cells
	Immune response IL-1 signaling pathway
	Immune response IL-2 activation and signaling pathway

5 R&D Systems Pathways for FOSB

	Inflammasome Activation Pathways
	Adipocytokines & Insulin Signaling
	Th1 Differentiation
	Toll-Like receptor Signaling Pathways
	TGF-beta Signaling Pathways

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FOSB (see all 7)

	iNOS Signaling
	SMAD Signaling Network
	Ceramide Pathway
	ILK Signaling
	ITK and TCR Signaling

3 Cell Signaling Technology (CST) Pathways for FOSB

	MAP Kinase Signaling
	Cell Cycle / Checkpoint Control
	Neuroscience

5/7 GeneGo (Thomson Reuters) Pathways for FOSB (see all 7)

	Mucin expression in CF via TLRs, EGFR signaling pathways
	Immune response IL-3 activation and signaling pathway
	Immune response CD16 signaling in NK cells
	Mucin expression in CF via IL-6, IL-17 signaling pathways
	Immune response IL-2 activation and signaling pathway

1 BioSystems Pathway for FOSB

TGF-beta Receptor Signaling Pathway

1 PharmGKB Pathway for FOSB

Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

1 Kegg Pathway (Kegg details for FOSB):

Osteoclast differentiation

FOSB for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FOSB

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

5/32 Interacting proteins for FOSB (P53539³ ENSP00000245919⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 32)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
JUN	P05412³, ENSP00000360266⁴	I2D: score=3 STRING: ENSP00000360266
JUNB	P17275³, ENSP00000303315⁴	I2D: score=3 STRING: ENSP00000303315
JUND	P17535³, ENSP00000252818⁴	I2D: score=3 STRING: ENSP00000252818
CREBBP	Q92793³, ENSP00000262367⁴	I2D: score=1 STRING: ENSP00000262367
ATF2	P15336³	I2D: score=1

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	TAS	1900040
GO:0007275	multicellular organismal development	TAS	8706134
GO:0007610	behavior	TAS	8706134
GO:0071277	cellular response to calcium ion	IEA	--

FOSB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FOSB for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FOSB
10/13 Novoseek chemical compound relationships for FOSB gene (see all 13) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
anisomycin	44.2	2	9528756 (1)
12-o-tetradecanoylphorbol 13-acetate	39.8	2	11751871 (1), 7931079 (1)
leucine	34.9	2	7919342 (1), 15828020 (1)
okadaic acid	34.8	6	9873060 (4), 8706012 (1)
phorbol	31.4	1	7671329 (1)
oligonucleotide	20.8	1	11751871 (1)
matrigel	19.3	1	15319566 (1)
kainate	11.7	1	7520539 (1)
carbachol	10.7	5	9523591 (4), 1328861 (1)
calcium	0	1	9523591 (1)

Search CenterWatch for drugs/clinical trials and news about FOSB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FOSB gene (2 alternative transcripts):

NM_001114171.1 NM_006732.2

Unigene Cluster for FOSB:

FBJ murine osteosarcoma viral oncogene homolog B

Hs.590958 [show with all ESTs]

Unigene Representative Sequence: BC036724

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000585836 ENST00000417353(uc010ekd.1 uc010eke.3 uc002pby.4)

ENST00000353609(uc002pbw.3 uc010eka.1 uc010ekb.1 uc002pbx.4 uc010ekf.3 uc002pca.4)

ENST00000591858 ENST00000443841(uc010ekc.1 uc010ekg.3) ENST00000590335

ENST00000592436 ENST00000592811 ENST00000586113 ENST00000586615 ENST00000589593

ENST00000587358

miRNA Products:		OriGene 3'-UTR Clone (see all 2): FOSB Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOSB
		8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate FOSB (see all 52):
		hsa-miR-2052 hsa-miR-19b-2* hsa-miR-513a-5p hsa-miR-128 hsa-miR-374a hsa-miR-766 hsa-miR-449a hsa-miR-4267

		SwitchGear 3'UTR luciferase reporter plasmid: FOSB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOSB (see all 4) OriGene shRNA RFP: FOSB OriGene siRNA: FOSB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOSB

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOSB (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOSB (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): FOSB (NM_006732)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOSB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOSB

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOSB Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FOSB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOSB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOSB

Additional cDNA sequence:

AF432216.1 AK097324.1 AK225070.1 AK292720.1 BC036724.1 BC040197.1 BC051767.1 BC063042.1

BC127825.1 BX538117.1 CR542101.1 D16366.1 EU178109.1 EU178110.1 EU178111.1 EU178112.1

EU178113.1 EU178114.1 EU178115.1 EU178116.1 L49169.1

22 DOTS entries:

DT.91704152 DT.40245732 DT.99937901 DT.448257 DT.121483522 DT.97769742 DT.100738687 DT.92461989

DT.91698465 DT.100783281 DT.121483409 DT.92461968 DT.121483503 DT.121483419 DT.121483506 DT.91659175

DT.92026343 DT.95254289 DT.97766554 DT.95168169 DT.95168170 DT.97814403

24/327 AceView cDNA sequences (see all 327):

AU118031 AA296039 BF109779 BG150133 AV719542 AU141406 BQ876665 BX538117

AU141819 F02073 BF871028 AI744962 BQ181364 AK097324 H42721 BF854518

BU146670 BF055464 AA235570 CA312265 AA664063 CA775066 CN483447 F05827

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for FOSB About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6
SP1:					-		-				-
SP2:											-
SP3:					-		-				-		-
SP4:							-				-
SP5:

ECgene alternative splicing isoforms for FOSB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FOSB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTACTTGT

About this image

FOSB expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Mature Granulosa Cells

Ovary

Somite

Thoracic Ventrolateral Dermomyotome Lip

Muscle Progenitor Cells

Skeletal Muscle

Adipose

Visceral White Adipose

Adipose

Umbilical Cord

Umbilical Veins

Umbilical Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

Secondary follicles (Primary Cell)

Ovary, Reproductive System

Nkx2-1 GFP+ cells (Efficient derivation...)

See FOSB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FOSB

SOURCE GeneReport for Unigene cluster: Hs.590958

SABiosciences Expression via Pathway-Focused PCR Array including FOSB:

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOSB Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FOSB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOSB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOSB

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOSB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FOSB gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Fosb^{1 , 5}	FBJ osteosarcoma oncogene B^{1, 5}	90.73(n)¹ 95.86(a)¹		7 (9.56 cM)⁵ 14282¹ NM_008036.2¹ NP_032062.1¹ 19302721⁵
lizard (Anolis carolinensis)	Reptilia	FOSB⁶	--	58(a)	1 ↔ 1	AAWZ02036043(28933-31999)
zebrafish (Danio rerio)	Actinopterygii	fosb¹	FBJ murine osteosarcoma viral oncogene homolog B	67.44(n) 74.42(a)		492346 NM_001007312.1 NP_001007313.1
fruit fly (Drosophila melanogaster)	Insecta	kay⁶	kayak	8(a)	1 → many	3R(25592497-25619838)

ENSEMBL Gene Tree for FOSB (if available)
TreeFam Gene Tree for FOSB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FOSB gene

FOSL1² JDP2² ATF3² FOS² FOSL2²

6 SIMAP similar genes for FOSB using alignment to 18 protein entries: FOSB_HUMAN (see all proteins):

ATF3 BATF JDP2 FOS FOSL2 FOSL1

FOSB for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11669290^1,2	H	--	42401104(+)	`CGCCGG/AACGCG`	1	--	ut5¹ ese³		4		NS EA	356
rs28381240^1,2	C	--	42401267(+)	`ACTGCA/GCAGAA`	1	--	ut5¹ ese³		7		NS NA	194
rs199692915^1,2	C	--	42401571(+)	`AGTCCA/CCCCAC`	2	P	syn¹		0	--	--	--	--
rs10418787^1,2	C,F,	--	42401913(+)	`CCCCTG/CCTCGG`	1	--	int¹		7		WA NA CSA EA	365
rs28381242^1,2	C,F,	--	42402570(+)	`TCCAGG/ACACAC`	1	--	int¹		5		NS	174
rs28381243^1,2	C,F,	--	42402620(+)	`TCCTCC/TGGTGT`	1	--	int¹		6		NS WA	166
rs28381244^1,2	C,F,	--	42403370(+)	`GCTTTT/CTCCCT`	1	--	int¹ trp³		5		NS	188
rs201608348^1,2	C	--	42403745(-)	`GGCCCA/CCCACT`	2	G	syn¹		0	--	--	--	--
rs11667571^1,2	C,F,A,H,	--	42404555(+)	`NNNNCC/TGGGCT`	1	--	int¹		7		NS NA	306
rs28381249^1,2	C,	--	42404786(+)	`TTCCCC/GGGGAG`	1	--	int¹ trp³		5		NS	188

HapMap Linkage Disequilibrium report for FOSB (45971253 - 45978437 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FOSB: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOSB

DNA2.0 Custom Variant and Variant Library Synthesis for FOSB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FOSB for disorders           About GeneDecksing

OMIM gene information: 164772    OMIM disorders: --

20/24 diseases for FOSB (see all 24):    About MalaCards

spinal cord injury subdural empyema osteosarcoma intracranial hypertension

familial breast cancer multiple myeloma breast cancer parkinson's disease

endometrial cancer oral cancer myeloma hepatocellular carcinoma

ovarian carcinoma cervical cancer cervicitis ovarian cancer

carcinoma pancreatic cancer breast carcinoma pancreatitis

2 diseases from the University of Copenhagen DISEASES database for FOSB:

Parkinson's disease Morphine dependence

6 Novoseek disease relationships for FOSB gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	1.85	12	10502734 (4), 19795327 (1), 15514944 (1), 9528756 (1) (see all 6)
necrosis	0	1	9528756 (1)
breast cancer	0	2	10918184 (1), 10502734 (1)
nsclc	0	1	9662339 (1)
carcinoma	0	1	15319566 (1)
cancer	0	1	19653276 (1)

Human Genome Epidemiology (HuGE) Navigator: FOSB (6 documents)

Export disorders for FOSB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FOSB gene, integrated from 9 sources (see all 125):
(articles sorted by number of sources associating them with FOSB)

Utopia: connect your pdf to the dynamic
world of online information

Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3. (PubMed id 1301997)^{1, 2, 3} Martin-Gallardo A.... Venter J.C. (1992)
Sequence analysis and expression in cultured lymphocytes of the human FOSB gene (G0S3). (PubMed id 8985116)^{1, 2, 9} Heximer S.P.... Forsdyke D.R. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Regulation of megakaryocytic differentiation of K562 cells by FosB, a member of the Fos family of AP-1 transcription factors. (PubMed id 19381435)^{1, 9} Limb J.K....Kim J. (2009)
A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity. (PubMed id 1900040)^{1, 9} Nakabeppu Y. and Nathans D. (1991)
An unexpected role for FosB in activation-induced cell death of T cells. (PubMed id 12618758)^{1, 9} Baumann S....Kirchhoff S. (2003)
Identification of immunohistochemical prognostic mark ers for survival after resection of pulmonary metastases from colorectal carcin oma. (PubMed id 19795327)^{1, 9} Pfannschmidt J....Herpel E. (2009)
Placental growth factor induces FosB and c-Fos gene expression via Flt-1 receptors. (PubMed id 14741347)^{1, 9} Holmes D.I. and Zachary I. (2004)
AP-1 protein induction during monopoiesis favors C/EB P: AP-1 heterodimers over C/EBP homodimerization and stimulates FosB transcript ion. (PubMed id 21543584)¹ Hong S....Friedman A.D. (2011)
Binding site specificity and factor redundancy in act ivator protein-1-driven human papillomavirus chromatin-dependent transcription. (PubMed id 21937452)¹ Wang W.M....Chiang C.M. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2354	HGNC: 3797	AceView: FOSB	Ensembl:ENSG00000125740	euGenes: HUgn2354
ECgene: FOSB	Kegg: 2354	H-InvDB: FOSB

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FOSB	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FOSB	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/fosb/

Intellectual Property for FOSB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FOSB gene:
Search GeneIP for patents involving FOSB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for FOSB (FosB/G0S3)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for FOSB
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOSB		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOSB
	OriGene Protein Over-expression Lysate for FOSB		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for FOSB		OriGene 3'-UTR Clone for FOSB
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOSB		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOSB
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for FOSB		OriGene Custom Protein Services for FOSB
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FOSB
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOSB
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOSB
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOSB
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOSB
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOSB

	GenScript Custom Purified and Recombinant Proteins Services for FOSB		GenScript cDNA clones with any tag delivered in your preferred vector for FOSB
	GenScript Custom Assay Services for FOSB		GenScript Superior Antibodies for FOSB
	GenScript Custom overexpressing Cell Line Services for FOSB		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for FOSB

	Regulatory tfbs in FOSB promoter
	Search Chromatin IP Primers for FOSB
	RT² qPCR Primer Assay in human, mouse, rat FOSB
	GNC Network for FOSB
	SABiosciences PCR Arrays including human, mouse, rat FOSB

Search Tocris compounds for FOSB

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	FOSB antibodies
	FOSB proteins
	FOSB lysates

	Search for Antibodies for FOSB at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for FOSB
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for FOSB

FOSB Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for FOSB

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOSB

	SwitchGear 3'UTR luciferase reporter plasmids for FOSB
	SwitchGear Promoter luciferase reporter plasmids for FOSB

ThermoFisher Antibody for FOSB

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOSB

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes FOSB gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

FOSB Gene

FBJ murine osteosarcoma viral oncogene homolog B

Aliases
for FOSB gene

Summaries
for FOSB gene

Genomic Views
for FOSB gene

Proteins
for FOSB gene

Protein Domains /
Families
for FOSB gene

Function
for FOSB gene

Pathways & Interactions
for FOSB gene

Drugs & Compounds
for FOSB gene

Transcripts
for FOSB gene

Expression
for FOSB gene

Orthologs
for FOSB gene

Paralogs
for FOSB gene

Genomic Variants
for FOSB gene

Disorders / Diseases
for FOSB gene

Publications
for FOSB gene

External Searches for FOSB gene

Genome Databases showing FOSB gene

Other Databases showing FOSB gene

Specialized Databases showing FOSB gene

Intellectual Property
for FOSB gene

Products
for FOSB gene

View Random Gene

Advanced Search

Export list of displayed genes

FOSB Gene

FBJ murine osteosarcoma viral oncogene homolog B

Aliasesfor FOSB gene

Summariesfor FOSB gene

Genomic Viewsfor FOSB gene

Proteinsfor FOSB gene

Protein Domains /Familiesfor FOSB gene

Functionfor FOSB gene

Pathways & Interactionsfor FOSB gene

Drugs & Compoundsfor FOSB gene

Transcriptsfor FOSB gene

Expression for FOSB gene

Orthologsfor FOSB gene

Paralogsfor FOSB gene

Genomic Variantsfor FOSB gene

Disorders / Diseasesfor FOSB gene

Publicationsfor FOSB gene

External Searches for FOSB gene

Genome Databases showing FOSB gene

Other Databases showing FOSB gene

Specialized Databases showing FOSB gene

Intellectual Propertyfor FOSB gene

Productsfor FOSB gene

View Random Gene

Aliases
for FOSB gene

Summaries
for FOSB gene

Genomic Views
for FOSB gene

Proteins
for FOSB gene

Protein Domains /
Families
for FOSB gene

Function
for FOSB gene

Pathways & Interactions
for FOSB gene

Drugs & Compounds
for FOSB gene

Transcripts
for FOSB gene

Expression
for FOSB gene

Orthologs
for FOSB gene

Paralogs
for FOSB gene

Genomic Variants
for FOSB gene

Disorders / Diseases
for FOSB gene

Publications
for FOSB gene

Intellectual Property
for FOSB gene

Products
for FOSB gene