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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FOS Gene

protein-coding   GIFtS: 73
GCID: GC14P075745

FBJ Murine Osteosarcoma Viral Oncogene Homolog

(Previous name: v-fos FBJ murine osteosarcoma viral oncogene homolog)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
FBJ Murine Osteosarcoma Viral Oncogene Homolog1 2     Cellular Oncogene C-Fos2
G0/G1 Switch Regulatory Protein 72 3     FBJ Murine Osteosarcoma Viral (V-Fos) Oncogene Homolog (Oncogene FOS)2
V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog1     p552
AP-12     Proto-Oncogene C-Fos2
C-FOS2     G0S73
Activator Protein 12     Cellular Oncogene Fos3

External Ids:    HGNC: 37961   Entrez Gene: 23532   Ensembl: ENSG000001703457   OMIM: 1648105   UniProtKB: P011003   

Export aliases for FOS gene to outside databases

Previous GC identifers: GC14P073251 GC14P069562 GC14P073735 GC14P074815 GC14P055913


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FOS Gene:
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins
that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As
such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and
transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death.
(provided by RefSeq, Jul 2008)

GeneCards Summary for FOS Gene: 
FOS (FBJ murine osteosarcoma viral oncogene homolog) is a protein-coding gene. Diseases associated with FOS include audiogenic seizures, and coffin-lowry syndrome, and among its related super-pathways are MAPK Cascade and BCR signaling pathway. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is FOSL1.

UniProtKB/Swiss-Prot: FOS_HUMAN, P01100
Function: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1
transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical
DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding
site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells
destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell
proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating
CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum

Gene Wiki entry for FOS (C-Fos) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FOS gene promoter:
         SRF   STAT1   SRF (504 AA)   MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOS promoter sequence
   Search SABiosciences Chromatin IP Primers for FOS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

FOS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOS gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P075745:  view genomic region     (about GC identifiers)

Start:
75,745,477 bp from pter      End:
75,748,937 bp from pter
Size:
3,461 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FOS_HUMAN, P01100 (See protein sequence)
Recommended Name: Proto-oncogene c-Fos  
Size: 380 amino acids; 40695 Da
Subunit: Heterodimer; with JUN (By similarity). Interacts with MAFB (By similarity). Component of the
SMAD3/SMAD4/JUN/FOS complex required for syngernistic TGF-beta-mediated transcription at the AP1 promoter site.
Interacts with SMAD3; the interaction is weak even on TGF-beta activation. Interacts with MAFB. Interacts with
DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with CDS1 and PI4K2A (By
similarity)
Subcellular location: Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In quiescent cells, present in very
small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum
and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and
Tyr-30
Developmental stage: Expressed at very low levels in quiescent cells. When cells are stimulated to re-enter
growth, they undergo 2 waves of expression, the first one peaks 7.5 minutes following FBS induction. At this
stage, the protein is localized endoplasmic reticulum. The second wave of expression occurs at about 20 minutes
after induction and peaks at 1 hour. At this stage, the protein becomes nuclear
3 PDB 3D structures from and Proteopedia for FOS:
1A02 (3D)        1FOS (3D)        1S9K (3D)    
Secondary accessions: P18849

Explore the universe of human proteins at neXtProt for FOS: NX_P01100

Explore proteomics data for FOS at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth factor (EGF).
    Phosphorylated, in vitro, by MAPK and RSK1. Phosphorylation on both Ser-362 and Ser-374 by MAPK1/2 and RSK1/2
    leads to protein stabilization with phosphorylation on Ser-374 being the major site for protein stabilization on
    NGF stimulation. Phosphorylation on Ser-362 and Ser-374 primes further phosphorylations on Thr-325 and Thr-331
    through promoting docking of MAPK to the DEF domain. Phosphorylation on Thr-232, induced by HA-RAS, activates the
    transcriptional activity and antagonizes sumoylation. Phosphorylation on Ser-362 by RSK2 in osteoblasts
    contributes to osteoblast transformation (By similarity)
  • UniProtKB: Constitutively sumoylated with SUMO1, SUMO2 and SUMO3. Desumoylated by SENP2. Sumoylation requires
    heterodimerization with JUN and is enhanced by mitogen stimulation. Sumoylation inhibits the AP-1 transcriptional
    activity and is, itself, inhibited by Ras-activated phosphorylation on Thr-232
  • UniProtKB: In quiescent cells, the small amount of FOS present is phosphorylated at Tyr-10 and Tyr-30 by SRC. This
    Tyr-phosphorylated form is cytosolic. In growing cells, dephosphorylated by PTPN2. Dephosphorylation leads to the
    association with endoplasmic reticulum membranes and activation of phospholipid synthesis
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P01100

  • FOS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FOS Protein Expression
    REFSEQ proteins: NP_005243.1  
    ENSEMBL proteins: 
     ENSP00000306245   ENSP00000450519   ENSP00000452443   ENSP00000442268   ENSP00000452386  
     ENSP00000452590   ENSP00000452440   ENSP00000451786   ENSP00000450886  
    Reactome Protein details: P01100
    Human Recombinant Protein Products for FOS: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FOS
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for FOS
    GenScript Custom Purified and Recombinant Proteins Services for FOS
    Novus Biologicals FOS Proteins
    Novus Biologicals FOS Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FOS 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005783endoplasmic reticulum IEA--

    FOS for ontologies           About GeneDecksing



    FOS Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of FOS
    R&D Systems Antibodies for FOS (c-Fos)
    Cell Signaling Technology (CST) Antibodies for FOS 
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    Novus Biologicals FOS Antibodies
    Abcam antibodies for FOS
    Cloud-Clone Corp. Antibodies for FOS 
    ThermoFisher Antibody for FOS
    LSBio Antibodies in human, mouse, rat for FOS 

    Assay Products for FOS: 
    EMD Millipore Kits and Assays for the Analysis of FOS
    OriGene Custom Assay Services for FOS
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FOS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FOS 
    Cloud-Clone Corp. CLIAs for FOS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bZIP: basic leucine zipper proteins

    2 InterPro protein domains:
     IPR004827 bZIP
     IPR000837 Leuzip_Fos

    Graphical View of Domain Structure for InterPro Entry P01100

    ProtoNet protein and cluster: P01100

    2 Blocks protein domains:
    IPB000837 Fos transforming protein signature
    IPB011616 bZIP transcription factor


    UniProtKB/Swiss-Prot: FOS_HUMAN, P01100
    Similarity: Belongs to the bZIP family. Fos subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    FOS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOS_HUMAN, P01100
    Function: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1
    transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical
    DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding
    site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells
    destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell
    proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating
    CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum

         Genatlas biochemistry entry for FOS:
    murine FBJ osteosarcoma viral (v-fos) oncogene homolog,ligand induced,immediate (primary) early response gene

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA9732876
    GO:0005515protein binding IPI16511568
    GO:0008134transcription factor binding IEA--
         
    FOS for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FOS:
     Decreased viability 

         15/19 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Fos) (see all 19):
     behavior/neurological  cellular  craniofacial  embryogenesis  endocrine/exocrine gland 
     growth/size  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  mortality/aging  nervous system  normal 

    FOS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FOS: Fostm1Wag Fostm1Pa

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FOS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FOS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FOS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FOS 

    10/2425 SABiosciences Target genes for FOS (see all 2425):
    A2ML1 A4GALT AAA1 AAAS AATF ABCA1 ABCA12 ABCA9 ABCB1 ABCB6

    miRNA
    Products:
        
    miRTarBase miRNAs that target FOS:
    hsa-mir-221 (MIRT004484), hsa-mir-101 (MIRT001219), hsa-mir-222 (MIRT004485)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOS
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate FOS (see all 45):
    hsa-miR-199a-3p hsa-miR-139-5p hsa-miR-29a hsa-miR-4267 hsa-miR-1244 hsa-miR-383 hsa-miR-155 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidFOS 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FOS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FOS
    Sirion Biotech Validated adenovirus to knockdown FOS in human, mouse 
                         Customized adenovirus for overexpression of FOS

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FOS (see all 7)
    OriGene ORF clones in mouse, rat for FOS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FOS (NM_005252)
    Sino Biological Human cDNA Clone for FOS
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOS
    Sirion Biotech Customized lentivirus for stable overexpression of FOS 
                         Customized lentivirus expression plasmids for stable overexpression of FOS 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for FOS
    Search LifeMap BioReagents cell lines for FOS
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FOS About   (see all 138)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1G-protein signaling Ras family GTPases in kinase cascades (scheme)
    G-protein signaling Ras family GTPases in kinase cascades (scheme)0.44
    Oncostatin M Signaling Pathway0.37
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    Activation of the AP-1 family of transcription factors0.33
    2B cell receptor signaling pathway
    B cell receptor signaling pathway0.42
    T cell receptor signaling pathway0.38
    BCR signaling pathway0.42
    TCR Signaling Pathway0.35
    3BAFF in B-Cell Signaling
    BAFF in B-Cell Signaling0.92
    RANK Pathway0.38
    APRIL Pathway0.92
    RANKL/RANK Signaling Pathway0.31
    RANK Signaling in Osteoclasts0.45
    4Development EGFR signaling pathway
    Development EGFR signaling pathway0.87
    GDNF-Family Ligands and Receptor Interactions0.41
    Development ERBB-family signaling0.57
    EGF Pathway0.41
    5Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Chagas disease (American trypanosomiasis)0.33
    Toll-like receptor signaling pathway0.93
    Hepatitis B0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/40 EMD Millipore Pathways for FOS (see all 40)
        Development Activation of ERK by Alpha-1 adrenergic receptors
    Immune response CD16 signaling in NK cells
    Immune response MIF-mediated glucocorticoid regulation
    Immune response IL-1 signaling pathway
    Transcription Role of VDR in regulation of genes involved in osteoporosis

    5/9 R&D Systems Pathways for FOS (see all 9)
        Inflammasome Activation Pathways
    Adipocytokines & Insulin Signaling
    IL-17 Signaling
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    5/82 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FOS (see all 82)
        UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    ERK5 Signaling
    UVA-Induced MAPK Signaling
    PACAP Signaling

    2 Cell Signaling Technology (CST) Pathways for FOS
        MAP Kinase Signaling
    Cell Cycle / Checkpoint Control

    1 Tocris Bioscience Pathway for FOS
        MAPK Pathway

    5/43 GeneGo (Thomson Reuters) Pathways for FOS (see all 43)
        Development CNTF receptor signaling
    Development EGFR signaling pathway
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
    Development VEGF-family signaling
    Development PDGF signaling via STATs and NF-kB

    5/51 BioSystems Pathways for FOS (see all 51)
        MAPK signaling pathway
    Myometrial Relaxation and Contraction Pathways
    TGF Beta Signaling Pathway
    Apoptosis Modulation and Signaling
    EGFR1 Signaling Pathway

    5 Sino Biological Pathways for FOS 
        TNF Signaling
    EGFR Signaling Pathway
    Non-Canonical Wnt Pathway
    p53 Pathway
    Death Receptor Signaling

    5/25        Reactome Pathways for FOS (see all 25)
        FCERI mediated MAPK activation
    Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Toll-Like Receptors Cascades
    TRAF6 Mediated Induction of proinflammatory cytokines

    2 PharmGKB Pathways for FOS
        EGFR Inhibitor Pathway, Pharmacodynamics
    Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    5/22         Kegg Pathways  (Kegg details for FOS) (see all 22):
        MAPK signaling pathway
    Osteoclast differentiation
    Toll-like receptor signaling pathway
    T cell receptor signaling pathway
    B cell receptor signaling pathway


    FOS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FOS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/307 Interacting proteins for FOS (P011001, 2, 3 ENSP000003062454) via UniProtKB, MINT, STRING, and/or I2D (see all 307)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNP054121, 2, 3, ENSP000003602664EBI-852851,EBI-852823 MINT-8077940 MINT-8077771 MINT-8077923 MINT-68804 MINT-8077906 MINT-8077789 MINT-8077872 MINT-8077889 MINT-8077856 MINT-8077649 MINT-8077677 MINT-8077831 MINT-8077811 I2D: score=13 STRING: ENSP00000360266
    ENSG00000237724P081073, ENSP000004063594I2D: score=1 STRING: ENSP00000406359
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 5/48 biological process terms (GO ID links to tree view) (see all 48):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001661conditioned taste aversion IEA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006306DNA methylation TAS9888853

    FOS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FOS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FOS

    1 DrugBank Compound for FOS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Nadroparin-- 9041-08-1targetinhibitor19261492 19757196

    10/138 Novoseek inferred chemical compound relationships for FOS gene (see all 138)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    12-o-tetradecanoylphorbol 13-acetate 73.6 155 10535756 (5), 1939341 (4), 1905005 (4), 1901945 (3) (see all 69)
    tyrosine 69.4 174 8896447 (3), 9476581 (3), 10849652 (3), 9113418 (3) (see all 99)
    pyroglutamyl-histidyl-glycine 67.1 1 12820376 (1)
    pd 98,059 66.7 53 10648884 (3), 17424890 (2), 11208903 (1), 19349923 (1) (see all 45)
    phorbol 66.4 27 9191080 (2), 8063733 (1), 1939341 (1), 1470918 (1) (see all 21)
    cycloheximide 62.9 54 8115044 (3), 8544401 (2), 8764176 (2), 17257889 (1) (see all 36)
    cyclic amp 58.6 125 7617161 (9), 11208903 (6), 11850128 (6), 1703775 (6) (see all 54)
    thymidine 58.6 47 8078487 (3), 10374349 (2), 1517237 (2), 11834522 (2) (see all 39)
    leucine 58.3 102 1901988 (4), 1739975 (4), 2113670 (4), 2133107 (2) (see all 61)
    viphyb 55.9 1 10670826 (1)

    Search CenterWatch for drugs/clinical trials and news about FOS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FOS gene: 
    NM_005252.3  

    Unigene Cluster for FOS:

    FBJ murine osteosarcoma viral oncogene homolog
    Hs.25647  [show with all ESTs]
    Unigene Representative Sequence: NM_005252
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303562(uc001xrn.3 uc010tva.2 uc010asi.3) ENST00000554617
    ENST00000556324 ENST00000554212 ENST00000535987 ENST00000555242 ENST00000555686
    ENST00000555672 ENST00000557139 ENST00000555347
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOS
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate FOS (see all 45):
    hsa-miR-199a-3p hsa-miR-139-5p hsa-miR-29a hsa-miR-4267 hsa-miR-1244 hsa-miR-383 hsa-miR-155 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidFOS 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK097379.1 AK290907.1 AK291326.1 AK298659.1 BC004490.2 BX647104.1 CR541785.1 CR542267.1 

    24/59 DOTS entries (see all 59):

    DT.75190910  DT.92454956  DT.120026  DT.92368522  DT.100878506  DT.120794307  DT.120794342  DT.120794385 
    DT.120794350  DT.120794371  DT.95295078  DT.100878521  DT.97826657  DT.100760490  DT.120794344  DT.120794362 
    DT.120794320  DT.120794349  DT.92454959  DT.100878503  DT.91886249  DT.95295140  DT.100878517  DT.120794287 

    24/783 AceView cDNA sequences (see all 783):

    CD678017 BP371866 BX360805 CB269340 BX647104 BQ270518 AW664593 D56718 
    BG695872 AI074096 BF063059 C17030 BM766015 D57539 BF477592 CA407027 
    BM707462 BP373616 CA771054 BQ182926 CA427750 CN480148 BM740929 AV654387 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for FOS (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
    SP1:              -     -                 -                       -                                 
    SP2:              -     -                                         -                                 
    SP3:              -     -                       -     -           -                                 
    SP4:              -     -     -                                                                     
    SP5:              -     -                                                                           


    ECgene alternative splicing isoforms for FOS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FOS expression in normal human tissues (normalized intensities)      FOS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAAAGTGA
    FOS Expression
    About this image


    FOS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Thalamus
             Human Brain Vascular Smooth Muscle Cells (HBVSMC)   
             Septum   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 11 entries
             Intervertebral Disc Nucleus Pulposus Cells Sacral Intervertebral Disc
             HyStem+BMP4-induced 4D20.8 cells
             Human Annulus Fibrosus Cells (HAFC)   
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Human fetal bone marrow-derived mesenchymal stromal cells
             HyStem+BMP4-induced 4D20.8 cells
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Human Umbillical Artery Smooth Muscle Cells (HUASMC)   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             Human Colonic Smooth Muscle Cells (HCoSMC)   
             rectum   

    See FOS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FOS

    SOURCE GeneReport for Unigene cluster: Hs.25647
        SABiosciences Expression via Pathway-Focused PCR Arrays including FOS (see all 29): 
              Insulin Signaling Pathway in human mouse rat
              HIV Host Response in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Antiviral Response in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FOS gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fos1 , 5 FBJ osteosarcoma oncogene1, 5 88.33(n)1
    93.68(a)1
      12 (39.70 cM)5
    142811  NM_010234.21  NP_034364.11 
     854738905 
    chicken
    (Gallus gallus)
    Aves FOS1 FBJ murine osteosarcoma viral oncogene homolog 76.7(n)
    80.39(a)
      396512  NM_205508.1  NP_990839.1 
    lizard
    (Anolis carolinensis)
    Reptilia FOS6
    Uncharacterized protein
    70(a)
    1 ↔ 1
    1(22458134-22462638)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX851015.12   -- 76.75(n)    BX851015.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fos2 v-fos FBJ murine osteosarcoma viral oncogene homolog 76.11(n)   394198  CA787334.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta kay6
    kayak
    11(a)
    1 → many
    3R(25592497-25619838)
    worm
    (Caenorhabditis elegans)
    Secernentea fos-16
    Protein FOS-1, isoform b
    14(a)
    1 → many
    V(6003601-6016087)


    ENSEMBL Gene Tree for FOS (if available)
    TreeFam Gene Tree for FOS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FOS gene
    FOSL12  FOSB2  FOSL22  
    6 SIMAP similar genes for FOS using alignment to 10 protein entries:     FOS_HUMAN (see all proteins):
    ATF3    JDP2    FOSL2    FOSB    BATF3    BATF

    FOS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/140 SNPs in FOS are shown (see all 140)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2008085291,2
    C--55915851(+) CTTAAA/GGNNNN 1 -- int10--------
    rs2012117211,2
    C--55915854(-) ACTTTC/TCCCTT 1 -- int10--------
    rs1885616261,2
    --56729620(+) GGCCCA/GGTTCC 1 -- us2k10--------
    rs101420781,2
    C,H--56729621(+) GCCCAG/TTTCCA 1 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs1409523481,2
    --56729662(+) TGCCGA/GGTTGG 1 -- us2k10--------
    rs1423911251,2
    C--56730012(+) CGCCCC/TTCTCC 1 -- us2k10--------
    rs1505408521,2
    --56730227(+) CCCGTC/GTTCCA 1 -- us2k10--------
    rs9322571,2
    C,F,A,H--56730247(+) GCCGCG/TCCTGG 1 -- us2k121Minor allele frequency- T:0.26MN NS EA NA WA CSA 2521
    rs1928943051,2
    --56730284(+) CAGGCG/TCAGCT 1 -- us2k10--------
    rs1394956841,2
    C--56730331(+) AAGTCC/TGCGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FOS (75745477 - 75748937 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FOS:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832833CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 164810    OMIM disorders: --

    20/178 diseases for FOS (see all 178):    About MalaCards
    audiogenic seizures    coffin-lowry syndrome    myositis ossificans    cerebral hypoxia
    familial medullary thyroid carcinoma    blood disorders    osteofibrous dysplasia    fibrodysplasia ossificans progressiva
    osteosarcoma    fibrous dysplasia    transient cerebral ischemia    motion sickness
    morphine dependence    pain agnosia    hypertrophic scars    skin cancer
    cutis laxa    periostitis    glucocorticoid resistance    splenic marginal zone lymphoma

    13 diseases from the University of Copenhagen DISEASES database for FOS:
    Cancer     Vascular disease     Pain agnosia     Cholera
    Schizophrenia     Morphine dependence     Migraine     Withdrawal disorder
    Eye disease     Arthritis     Toxic encephalopathy     Parkinson's disease
    Kidney disease

    FOS for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/91 Novoseek inferred disease relationships for FOS gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 46.7 255 15514944 (3), 1348920 (3), 8491516 (3), 11488520 (3) (see all 99)
    leukemia t-cell 45 4 1916630 (1), 7732661 (1), 11145887 (1), 8361755 (1)
    retinoblastoma 44.1 32 8872049 (3), 9364216 (3), 1652755 (1), 10757447 (1) (see all 21)
    neoplastic transformation 37.6 4 8872049 (1), 9111306 (1), 18757399 (1), 17957143 (1)
    osteosarcoma 36.6 46 9778623 (3), 9672192 (3), 11398843 (3), 7576109 (2) (see all 25)
    breast cancer 36.5 66 16027729 (5), 15090535 (4), 7657391 (3), 8206948 (2) (see all 43)
    myeloid leukemia 34 6 1939341 (2), 8462021 (1), 1732724 (1), 8404639 (1) (see all 5)
    hyperalgesia 32.1 19 10082899 (4), 10082898 (3), 16522746 (2), 14622822 (2) (see all 11)
    necrosis 30.2 44 8491516 (3), 8063765 (2), 10873159 (1), 19026727 (1) (see all 37)
    teratocarcinoma 27.1 2 11402055 (1), 2157182 (1)

    Genetic Association Database (GAD): FOS
    Human Genome Epidemiology (HuGE) Navigator: FOS (27 documents)
    Tumor Gene Database (TGDB): FOS

    Export disorders for FOS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FOS gene, integrated from 9 sources (see all 2812):
    (articles sorted by number of sources associating them with FOS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation. (PubMed id 16055710)1, 2, 3, 9 Bossis G....Piechaczyk M. (2005)
    2. Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1. (PubMed id 16123044)1, 3, 9 Monje P....Gutkind J.S. (2005)
    3. The kinase c-Src and the phosphatase TC45 coordinately regulate c-Fos tyrosine phosphorylation and c-Fos phospholipid synthesis activa tion capacity. (PubMed id 22105363)1, 2 Ferrero G.O....Caputto B.L. (2012)
    4. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    5. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    6. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    9. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
    10. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2353 HGNC: 3796 AceView: FOS Ensembl:ENSG00000170345 euGenes: HUgn2353
    ECgene: FOS Kegg: 2353 H-InvDB: FOS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FOS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FOS Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fos/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FOS gene:
    Search GeneIP for patents involving FOS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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