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FOS Gene

protein-coding GIFtS: 71

GC14P074815

v-fos FBJ murine osteosarcoma viral oncogene homolog
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AP-1 ^¹, ²
C-FOS ^²
G0S7 ^³
c-fos ^¹

Descriptions
Cellular oncogene fos ^³
FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS) ^²
G0/G1 switch regulatory protein 7 ^³
activator protein 1 ^²
cellular oncogene c-fos ^²
v-fos FBJ murine osteosarcoma viral oncogene homolog ^²

External Ids
HGNC: 3796¹
Entrez Gene: 2353²
UniProtKB: P01100³
Ensembl: ENSG00000170345⁷

Search outside databases for aliases for FOS gene

Previous GC identifers: GC14P073251 GC14P069562 GC14P073735

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FOS:

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine

zipper proteins that can dimerize with proteins of the JUN family, thereby forming the

transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of

cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene

has also been associated with apoptotic cell death. [provided by RefSeq]

UniProtKB/Swiss-Prot: FOS_HUMAN, P01100

Function: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the

JUN/AP-1 transcription factor. In the heterodimer, c-fos and JUN/AP-1 basic regions each seems to

interact with symmetrical DNA half sites. Has a critical function in regulating the development of

cells destined to form and maintain the skeleton. It is thought to have an important role in

signal transduction, cell proliferation and differentiation

Gene Wiki entry for FOS (C-Fos)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FOS gene

Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.3 HGNC cytogenetic band: 14q24.3

FOS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P074815: (about GC identifiers)

Start:	74,815,284 bp from pter
End:	74,818,685 bp from pter
Size:	3,402 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FOS_HUMAN, P01100 (See protein sequence)

Recommended Name: Proto-oncogene protein c-fos

Size: 380 amino acids; 40695 Da

Subunit: Heterodimer with JUN. Interacts with DSIPI; this interaction inhibits the binding of

active AP1 to its target DNA. Interacts with MAFB (By similarity)

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1A02 (3D)

1FOS (3D)

1S9K (3D)

Secondary accessions: P18849

Post-translational modifications:

Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth

factor (EGF). Phosphorylated, in vitro, by MAPK and RSK1. Phosphorylation on both Ser-362 and

Ser-374 by MAPK1/2 and RSK1/2 leads to protein stabilization with phosphorylation on Ser-374 being

the major site for protein stabilization on NGF stimulation. Phosphorylation on Ser-362 and

Ser-374 primes further phosphorylations on Thr-325 and Thr-331 through promoting docking of MAPK

to the DEF domain. Phosphorylation on Thr-232, induced by HA-RAS, activates the transcriptional

activity and antagonizes sumoylation. Phosphorylation on Ser-362 by RSK2 in osteoblasts

contributes to osteoblast transformation (By similarity)¹

Constitutively sumoylated by SUMO1, SUMO2 and SUMO3. Desumoylated by SENP2. Sumoylation requires

heterodimerization with JUN and is enhanced by mitogen stimulation. Sumoylation inhibits the AP-1

transcriptional activity and is, itself, inhibited by Ras-activated phosphorylation on Thr-232¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005243.1

ENSEMBL proteins:

ENSP00000306245

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (c-Fos)
	Human Recombinant Proteins from Abnova (FOS)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	9443941
GO:0005667	transcription factor complex	IEA	--

About this table

Antibodies for FOS:

	Invitrogen Antibodies for FOS
	Millipore Mono- and Polyclonal Antibodies for the study of FOS
	Sigma-Aldrich Antibodies for FOS
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for FOS (c-Fos, Fos)
	Antibodies from Abcam (c-Fos), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FOS)
	Novus Biologicals Antibodies for FOS

Assays for FOS:

	Invitrogen Assays for FOS
	Millipore Kits and Assays for the Analysis of FOS
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P01100

ProtoNet protein and cluster: P01100

2 Blocks protein families:

IPB000837 Fos transforming protein signature

IPB011616 bZIP transcription factor

UniProtKB/Swiss-Prot: FOS_HUMAN, P01100

Similarity: Belongs to the bZIP family. Fos subfamily

Similarity: Contains 1 bZIP domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FOS)
		Millipore RNAi Products for the Analysis of FOS Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (FOS)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005252

Applied Biosystems Silencer® siRNAs for FOS

Sigma-Aldrich siRNA for FOS

Sigma-Aldrich shRNA Panels and shRNA for FOS

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FOS
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005252
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005252
untagged cDNA clone in CMV expression vector: NM_005252

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005252

UniProtKB/Swiss-Prot: FOS_HUMAN, P01100

Function: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the

JUN/AP-1 transcription factor. In the heterodimer, c-fos and JUN/AP-1 basic regions each seems to

interact with symmetrical DNA half sites. Has a critical function in regulating the development of

cells destined to form and maintain the skeleton. It is thought to have an important role in

signal transduction, cell proliferation and differentiation

Genatlas biochemistry entry for FOS:

murine FBJ osteosarcoma viral (v-fos) oncogene homolog,ligand induced,immediate (primary) early

response gene

15/17 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Fos) (see all 17 ):

behavior/neurological	craniofacial	embryogenesis	endocrine/exocrine gland	growth/size
hearing/vestibular/ear	hematopoietic system	immune system	lethality-prenatal/perinatal	life span-post-weaning/aging
limbs/digits/tail	nervous system	normal	reproductive system	skeleton

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003690	double-stranded DNA binding	IEA	--
GO:0003700	transcription factor activity	IEA	--
GO:0003704	specific RNA polymerase II transcription factor activity	TAS	10918580
GO:0010843	promoter binding	IDA	9732876
GO:0046332	SMAD binding	IPI	9732876

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/47 Sigma-Aldrich "Your Favorite Gene" Pathways for FOS (Your Favorite Gene powered by Ingenuity) (see all 47 )

Relaxin Signaling
EGF Signaling
Corticotropin Releasing Hormone Signaling
IL-3 Signaling
GNRH Signaling

GeneDecks FOS for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for FOS

5/423 Interacting proteins for FOS (P01100^{1, 2} ENSP00000306245³) via UniProtKB, MINT, and/or STRING (see all 423 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
JUNB	P17275², ENSP00000303315³	MINT-1788374 STRING (score=.909)
EDF1	O60869-1¹	EBI-852851, EBI-781310
JUN	P05412²	MINT-68804
NFATC2	ENSP00000360622³	STRING (score=.999)
ETS1	ENSP00000324578³	STRING (score=.998)

About this table

5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006306	DNA methylation	TAS	9888853
GO:0006954	inflammatory response	TAS	9443941
GO:0007399	nervous system development	IEA	--
GO:0031668	cellular response to extracellular stimulus	IEA	--
GO:0034614	cellular response to reactive oxygen species	IDA	17217916

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for FOS

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FOS
10/37 Novoseek chemical compound relationships for FOS gene (see all 37 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
12-o-tetradecanoylphorbol 13-acetate	73.23	152	10535756 (5), 1939341 (4), 1905005 (4), 1901945 (3) (see all 66)
tyrosine	70.18	173	8896447 (3), 9476581 (3), 10849652 (3), 9113418 (3) (see all 99)
phorbol	66.92	27	9191080 (2), 8063733 (1), 1939341 (1), 1470918 (1) (see all 21)
pd 98,059	66.17	52	10648884 (3), 17424890 (2), 11208903 (1), 19349923 (1) (see all 44)
cyclic amp	59.12	125	7617161 (9), 11208903 (6), 11850128 (6), 1703775 (6) (see all 54)
leucine	59.01	102	1901988 (4), 1739975 (4), 2113670 (4), 2133107 (2) (see all 61)
thymidine	58.75	47	8078487 (3), 10374349 (2), 1517237 (2), 11834522 (2) (see all 39)
viphyb	56.31	1	10670826 (1)
forskolin	54.74	60	9512670 (3), 8226882 (3), 8912813 (2), 9544985 (2) (see all 43)
phosphocitrate	52.70	5	2118343 (2), 8608166 (2), 10823243 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FOS)
		Millipore RNAi Products for the Analysis of FOS Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (FOS)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005252

Sigma-Aldrich siRNA for FOS

Sigma-Aldrich shRNA Panels and shRNA for FOS

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005252

REFSEQ mRNAs for FOS gene:

NM_005252.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005252

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005252
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005252
                                 untagged cDNA clone in CMV expression vector: NM_005252

Additional cDNA sequence:

AK097379.1 AK290907.1 AK291326.1 AK298659.1 BC004490.2 BX647104.1 CR541785.1 CR542267.1

CR612516.1 CR620080.1

24/59 DOTS entries (see all 59 ):

DT.75190910 DT.92454956 DT.92368522 DT.120026 DT.100878506 DT.120794307 DT.120794342 DT.120794385

DT.120794371 DT.120794350 DT.95295078 DT.100878521 DT.97826657 DT.100760490 DT.120794344 DT.120794362

DT.120794320 DT.120794349 DT.92454959 DT.100878503 DT.91886249 DT.95142775 DT.95295140 DT.100878517

24/783 AceView cDNA sequences (see all 783 ):

AV654387 AL602826 CA406037 BM740929 BG695872 AV714666 CA393096 AA371089

BM742157 CA392839 AA335648 CN480148 AI074096 CB266234 CD677510 CA427750

CA413754 CA413058 AW664593 D56718 AV656501 CA391194 CA406188 BP372932

highest scoring ESTs for FOS:

AA020879 AA280404 AA284642 AA295986 AA300350 AA319315 AA335648 AA337290 AA344052 AA351062

Unigene Cluster for FOS:

V-fos FBJ murine osteosarcoma viral oncogene homolog

Hs.707896 [show with all ESTs]

Unigene Representative Sequence: BX647104

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for FOS (see all 7 )

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	·	2d	·	2e	^	3	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	·	6e
SP1:					-		-						-								-
SP2:					-		-														-
SP3:					-		-								-		-				-
SP4:					-		-		-
SP5:					-		-

About this scheme

ECgene alternative splicing isoforms for FOS

1 Ensembl transcript including schematic representation:

ENST00000303562

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FOS expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FOS

¹ / ² / ³

6 probe-sets matching FOS gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1916_s_at²^{, 3}	U95-A	1	1.00	1.00	0.92	1.01	V01512	0.20	1.00	0.72	1
1915_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.01	V01512	0.20	1.00	0.72	1
2094_s_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.96	K00650	0.20	1.00	0.72	1
71524_at²^{, 3}	U95-D	1	0.31	1.00	0.88	1.02	AI610837	0.40	1.00	0.76	1
209189_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC004490	0.80	1.00	0.91	1
209189_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.707896
Expression variation in blood from EXPOLDB for FOS

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FOS gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FOS¹	--	v-fos FBJ murine osteosarcoma viral oncogene homolog	92.19(n) 97.11(a)	490792 XM_547914.2 XP_547914.1
chimpanzee (Pan troglodytes)	FOS¹	--	v-fos FBJ murine osteosarcoma viral oncogene homolog	99.56(n) 99.74(a)	453047 XM_510075.2 XP_510075.2
cow (Bos taurus)	FOS¹	--	v-fos FBJ murine osteosarcoma viral oncogene homolog	92.02(n) 96.32(a)	280795 NM_182786.2 NP_877587.1
rat (Rattus norvegicus)	Fos¹	--	FBJ osteosarcoma oncogene	88.42(n) 94.21(a)	314322 NM_022197.1 NP_071533.1
mouse (Mus musculus)	Fos^{1, 5}	12 (40.00 cM)⁵	FBJ osteosarcoma oncogene^{1, 5}	88.25(n)¹ 93.68(a)¹	14281¹ NM_010234.2¹ NP_034364.1¹ AK154418⁵ AK159688⁵ (see all 12)

About this table Species with no ortholog for FOS

ENSEMBL Gene Tree for FOS

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FOS gene

FOSL1² FOSB² FOSL2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/39 NCBI SNPs in FOS are shown (see all 39 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 38)

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs7101^1,2	A,C,F,H,O	74815379(+)	`CTGCTT/CCACAG`	1	--	ut5¹ ese³		14	EA NS MN EU WA	4108
	rs932257^1,2	A,C,F	74814057(+)	`GCCGCG/TCCTGG`	1	--	ng5¹		1	MN	184
--	rs4645850^1,2	C,F	74814792(+)	`TCCCCC/ACCGAC`	1	--	ng5¹		7	NS	826
	rs2234706^1,2	C,F	74815047(+)	`ACCCCC/G/TCATCT`	1	--	ng5¹		4	NS MN EA	1530
	rs2239615^1,2	C,F	74815304(+)	`GAGCAA/TCTGAG`	1	--	ut5¹ ese³		11	EA NS MN NA	4426
	rs4645861^1,2	H	74818955(+)	`TCAGTA/GCTCGC`	1	--	ng3¹		5	NS EU EA WA	594
	rs4645858^1,2	H	74818361(+)	`AGATAC/TGACTT`	1	--	ut3¹ ese³		5	NS EU EA WA	556
	rs4645860^1,2	H	74818829(+)	`CTATAG/CAGCTG`	1	--	ng3¹		5	NS EU EA WA	594
--	rs4645859^1,2	F	74818797(+)	`TGTCTG/TATCCC`	1	--	ng3¹		1	NS	180
--	rs4645849^1,2	F	74814789(+)	`CCATCC/GCCCCC`	1	--	ng5¹		1	NS	168

About this table

HapMap Linkage Disequilibrium images for FOS (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 164810

10/92 Novoseek disease relationships for FOS gene (see all 92 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	47.10	247	15514944 (3), 1348920 (3), 8491516 (3), 11488520 (3) (see all 99)
leukemia t-cell	46.04	4	1916630 (1), 7732661 (1), 11145887 (1), 8361755 (1)
retinoblastoma	44.67	31	8872049 (3), 9364216 (3), 1652755 (1), 10757447 (1) (see all 20)
neoplastic transformation	38.83	4	8872049 (1), 9111306 (1), 18757399 (1), 17957143 (1)
osteosarcoma	38.14	46	9778623 (3), 9672192 (3), 11398843 (3), 7576109 (2) (see all 25)
myeloid leukemia	35.23	6	1939341 (2), 8462021 (1), 1732724 (1), 8404639 (1) (see all 5)
breast cancer	34.81	65	16027729 (5), 15090535 (4), 7657391 (3), 8206948 (2) (see all 42)
hyperalgesia	31.79	17	10082899 (4), 10082898 (3), 16522746 (2), 14622822 (2) (see all 9)
necrosis	29.67	43	8491516 (3), 8063765 (2), 10873159 (1), 19026727 (1) (see all 36)
teratocarcinoma	28.05	2	11402055 (1), 2157182 (1)

About this table

1 PharmGKB disease relationship for FOS gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

About this table

Genetic Association Database: FOS
Human Genome Epidemiology Navigator: FOS (12 documents)
Tumor Gene Database: FOS

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/2127 PubMed articles for FOS gene (see all 2127 ):

Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation. (PubMed id 16055710)^{1, 2, 3, 4} Bossis G....Piechaczyk M. (2005)
Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1. (PubMed id 16123044)^{1, 2, 3} Monje P....Gutkind J.S. (2005)
The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PubMed id 17203973)^{3, 4} Vasilescu J.... Figeys D. (2007)
Forebrain patterns of c-Fos and FosB induction during cancer-associated anorexia-cachexia in rat. (PubMed id 15926923)^{2, 3} Konsman J.P. and Blomqvist A. (2005)
LRP5, low-density-lipoprotein-receptor-related protein 5, is a determinant for bone mineral density. (PubMed id 14727154)^{3, 6} Mizuguchi T.... Yoshiura K. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)^{3, 4} Heilig R.... Weissenbach J. (2003)
Crystal structure of the heterodimeric bZIP transcription factor c- Fos-c-Jun bound to DNA. (PubMed id 7816143)^{3, 4} Glover J.N. and Harrison S.C. (1995)
Retrovirus-mediated gene transfer of a human c-fos cDNA into mouse bone marrow stromal cells. (PubMed id 1658710)^{3, 4} Roux P....Piechaczyk M. (1991)
Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. (PubMed id 2516827)^{3, 4} Hai T.... Green M.R. (1989)

(in PubMed, OMIM, and NCBI Bookshelf)
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2353	HGNC: 3796	AceView: FOS	Ensembl:ENSG00000170345	euGenes: HUgn2353
ECgene: FOS	H-InvDB: FOS

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for FOS	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/fos/

Licensable Technologies for FOS
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FOS:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FOS-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FOS		Antibodies for FOS
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FOS		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (FOS)
	Antibodies (FOS)
	Chimera RNAi (FOS)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for FOS (c-Fos, Fos)

	Recombinant Proteins (c-Fos)
	Antibodies (c-Fos)

Search OriGene for FOS

Search Tocris compounds for FOS

	Drugs for FOS
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for FOS

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
FOS Gene at Home site.
Version 2.41.1
server5.xennexinc.com

FOS Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for FOS

Summaries
for FOS

Genomic Location
for FOS

Proteins
for FOS

Protein Domains/
Families
for FOS

Gene Function
for FOS

Pathways & Interactions
for FOS

Drugs & Compounds
for FOS

Transcripts
for FOS

Expression
for FOS

Orthologs
for FOS

Paralogs
for FOS

SNPs/Variants
for FOS

Disorders & Mutations
for FOS

Medical News
for FOS

Publications
for FOS

Search for FOS

Genome Databases showing FOS

Other Databases showing FOS

Specialized Databases showing FOS

Licensable Technologies
for FOS

Services
for FOS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FOS Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor FOS

Summariesfor FOS

Genomic Locationfor FOS

Proteinsfor FOS

Protein Domains/Familiesfor FOS

Gene Functionfor FOS

Pathways & Interactionsfor FOS

Drugs & Compoundsfor FOS

Transcriptsfor FOS

Expression for FOS

Orthologsfor FOS

Paralogsfor FOS

SNPs/Variantsfor FOS

Disorders & Mutationsfor FOS

Medical Newsfor FOS

Publicationsfor FOS

Search for FOS

Genome Databases showing FOS

Other Databases showing FOS

Specialized Databases showing FOS

Licensable Technologiesfor FOS

Servicesfor FOS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FOS

Summaries
for FOS

Genomic Location
for FOS

Proteins
for FOS

Protein Domains/
Families
for FOS

Gene Function
for FOS

Pathways & Interactions
for FOS

Drugs & Compounds
for FOS

Transcripts
for FOS

Expression
for FOS

Orthologs
for FOS

Paralogs
for FOS

SNPs/Variants
for FOS

Disorders & Mutations
for FOS

Medical News
for FOS

Publications
for FOS

Licensable Technologies
for FOS

Services
for FOS