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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FOS Gene

protein-coding GIFtS: 72
GCID: GC14P075745

FBJ murine osteosarcoma viral oncogene homolog

(Previous name: v-fos FBJ murine osteosarcoma viral oncogene homolog )

Explore 194 diseases affiliated with
FOS via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
FBJ Murine Osteosarcoma Viral Oncogene Homolog¹ ²		Cellular Oncogene C-Fos²
AP-1¹ ²		FBJ Murine Osteosarcoma Viral (V-Fos) Oncogene Homolog (Oncogene FOS)²
G0/G1 Switch Regulatory Protein 7² ³		P55¹
C-Fos¹		Proto-Oncogene C-Fos²
V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog¹		G0S7³
C-FOS²		Cellular Oncogene Fos³
Activator Protein 1²

External Ids:	HGNC: 3796¹	Entrez Gene: 2353²	Ensembl: ENSG00000170345⁷	OMIM: 164810⁵	UniProtKB: P01100³

Export aliases for FOS gene to outside databases

Previous GC identifers: GC14P073251 GC14P069562 GC14P073735 GC14P074815 GC14P055913

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FOS:

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that

can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS

proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases,

expression of the FOS gene has also been associated with apoptotic cell death. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FOS_HUMAN, P01100

Function: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription

factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On

TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate

TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and

maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and

differentiation

Gene Wiki entry for FOS (C-Fos)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FOS gene promoter:
SRF STAT1 SRF (504 AA) MyoD
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FOS promoter sequence

Search SABiosciences Chromatin IP Primers for FOS

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOS

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.3 HGNC cytogenetic band: 14q24.3

FOS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOS gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P075745: view genomic region (about GC identifiers)

Start:	75,745,477 bp from pter	End:	75,748,937 bp from pter
Size:	3,461 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FOS_HUMAN, P01100 (See protein sequence)

Recommended Name: Proto-oncogene c-Fos

Size: 380 amino acids; 40695 Da

Subunit: Heterodimer; with JUN (By similarity). Interacts with MAFB (By similarity). Component of the

SMAD3/SMAD4/JUN/FOS complex required for syngernistic TGF-beta-mediated transcription at the AP1 promoter site.

Interacts with SMAD3; the interaction is weak even on TGF-beta activation. Interacts with MAFB. Interacts with DSIPI;

this interaction inhibits the binding of active AP1 to its target DNA

Subcellular location: Nucleus

3 PDB 3D structures from and Proteopedia for FOS:

1A02 (3D)

1FOS (3D)

1S9K (3D)

Secondary accessions: P18849

Explore the universe of human proteins at neXtProt for FOS: NX_P01100

Post-translational modifications:

Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth factor (EGF).

Phosphorylated, in vitro, by MAPK and RSK1. Phosphorylation on both Ser-362 and Ser-374 by MAPK1/2 and RSK1/2 leads to

protein stabilization with phosphorylation on Ser-374 being the major site for protein stabilization on NGF

stimulation. Phosphorylation on Ser-362 and Ser-374 primes further phosphorylations on Thr-325 and Thr-331 through

promoting docking of MAPK to the DEF domain. Phosphorylation on Thr-232, induced by HA-RAS, activates the

transcriptional activity and antagonizes sumoylation. Phosphorylation on Ser-362 by RSK2 in osteoblasts contributes to

osteoblast transformation (By similarity)¹

Constitutively sumoylated with SUMO1, SUMO2 and SUMO3. Desumoylated by SENP2. Sumoylation requires heterodimerization

with JUN and is enhanced by mitogen stimulation. Sumoylation inhibits the AP-1 transcriptional activity and is,

itself, inhibited by Ras-activated phosphorylation on Thr-232¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P01100

FOS Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005243.1

ENSEMBL proteins:

ENSP00000306245 ENSP00000450519 ENSP00000452443 ENSP00000442268 ENSP00000452386

ENSP00000452590 ENSP00000452440 ENSP00000451786 ENSP00000450886

Reactome Protein details: P01100
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: FOS OriGene Custom Protein Services for FOS
	GenScript Custom Purified and Recombinant Proteins Services for FOS
	Novus Biologicals FOS Proteins Novus Biologicals FOS Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FOS

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005667	transcription factor complex	IEA	--
GO:0005730	NOT nucleolus	IDA	--

FOS for ontologies About GeneDecksing

FOS Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of FOS
	R&D Systems Antibodies for FOS (c-Fos)
	Cell Signaling Technology (CST) Antibodies for FOS
	OriGene Antibodies: FOS OriGene Custom Antibody Services for FOS
	GenScript Superior Antibodies for FOS
	Novus Biologicals FOS Antibodies
	Abcam antibodies for FOS
	Uscn Antibodies for FOS
	ThermoFisher Antibody for FOS

Assay Products for FOS:

	EMD Millipore Kits and Assays for the Analysis of FOS
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FOS
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FOS

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FOS for domains About GeneDecksing

2 InterPro domains/families:

IPR004827 bZIP

IPR000837 Leuzip_Fos

Graphical View of Domain Structure for InterPro Entry P01100

ProtoNet protein and cluster: P01100

2 Blocks protein families:

IPB000837 Fos transforming protein signature

IPB011616 bZIP transcription factor

UniProtKB/Swiss-Prot: FOS_HUMAN, P01100

Similarity: Belongs to the bZIP family. Fos subfamily

Similarity: Contains 1 bZIP (basic-leucine zipper) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FOS_HUMAN, P01100

Function: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription

factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On

TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate

TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and

maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and

differentiation

Genatlas biochemistry entry for FOS:

murine FBJ osteosarcoma viral (v-fos) oncogene homolog,ligand induced,immediate (primary) early response gene

		10/2460 SABiosciences Target genes for FOS (see all 2460):
		A2ML1 A4GALT AAA1 AAAS AATF ABCA1 ABCA12 ABCA9 ABCB1 ABCB6

miRNA Products:		miRTarBase miRNAs that target FOS: hsa-mir-221 (MIRT004484), hsa-mir-101 (MIRT001219), hsa-mir-222 (MIRT004485)

		OriGene 3'-UTR Clone: FOS Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOS
		8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate FOS (see all 45):
		hsa-miR-199a-3p hsa-miR-139-5p hsa-miR-29a hsa-miR-4267 hsa-miR-1244 hsa-miR-383 hsa-miR-155 hsa-miR-3148

		SwitchGear 3'UTR luciferase reporter plasmid: FOS 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOS (see all 7) OriGene shRNA RFP: FOS OriGene siRNA: FOS
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOS

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for FOS

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOS (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOS OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FOS (NM_005252)
		Sino Biological Human cDNA Clone for FOS
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOS
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOS

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FOS
		Search LifeMap BioReagents cell lines for FOS

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOS

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003690	double-stranded DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IDA	9732876
GO:0005515	protein binding	IPI	--
GO:0008134	transcription factor binding	IEA	--

FOS for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for FOS:

Decreased viability

Animal Models:
Mouse knock-outs for FOS: Fos^tm1Wag Fos^tm1Pa
15/19 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Fos) (see all 19):

behavior/neurological	cellular	craniofacial	embryogenesis	endocrine/exocrine gland
growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system
integument	limbs/digits/tail	mortality/aging	nervous system	normal

FOS for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/123 super-pathways (see all 123) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TRAF6 Mediated Induction of proinflammatory cytokines

8/19 pathways (see all 19)
TRAF6 Mediated Induction of proinflammatory cytokines	1.00	Toll Like Receptor TLR1:TLR2 Cascade	0.78
MAP kinase activation in TLR cascade	0.88	Toll Like Receptor 2 (TLR2) Cascade	0.78
Toll Like Receptor 5 (TLR5) Cascade	0.86	MyD88:Mal cascade initiated on plasma membrane	0.78
Toll Like Receptor 10 (TLR10) Cascade	0.86	TRIF-mediated TLR3/TLR4 signaling	0.73

Development_CNTF receptor signaling

8/9 pathways (see all 9)
Development_CNTF receptor signaling	1.00	Immune response_IL-6 signaling pathway	0.30
Development CNTF receptor signaling	1.00	Immune response IL-6 signaling pathway	0.30
Development_Growth hormone signaling via PI3K/AKT and MAPK cascades	0.34	Development_Leptin signaling via JAK/STAT and MAPK cascades	0.25
Development Growth hormone signaling via PI3K/AKT and MAPK cascades	0.34	Development Leptin signaling via JAK/STAT and MAPK cascades	0.25

Development Angiotensin activation of ERK

8/9 pathways (see all 9)
Development Angiotensin activation of ERK	1.00	Development G-Proteins mediated regulation MARK-ERK signaling	0.66
Development_Angiotensin activation of ERK	0.98	Development_EDNRB signaling	0.54
Development_ACM2 and ACM4 activation of ERK	0.74	Development EDNRB signaling	0.54
Development ACM2 and ACM4 activation of ERK	0.74	Cholinergic synapse	0.30

ErbB4 Pathway

8/9 pathways (see all 9)
ErbB Family Pathway	0.59	LPS Stimulated MAPK Signaling	0.36
ErbB2-ErbB3 Heterodimers	0.47	TREM1 Pathway	0.32
IL-2 Pathway	0.46	HMGB1 Pathway	0.32
UVC-Induced MAPK Signaling	0.44	PACAP Signaling	0.17

G-protein signaling_Ras family GTPases in kinase cascades (scheme)

G-protein signaling Ras family GTPases in kinase cascades (scheme)	1.00	Activation of the AP-1 family of transcription factors	0.33
G-protein signaling_Ras family GTPases in kinase cascades (scheme)	1.00	Immune response_Role of integrins in NK cells cytotoxicity	0.28
Immune response_Oncostatin M signaling via MAPK in human cells	0.39	Immune response Role of integrins in NK cells cytotoxicity	0.28
Immune response Oncostatin M signaling via MAPK in human cells	0.39	Oncostatin M Signaling Pathway	0.15

Pathway sources
See GeneCards unified pathways
Show all pathways

5/40 EMD Millipore Pathways for FOS (see all 40)

	Development Activation of ERK by Alpha-1 adrenergic receptors
	Immune response CD16 signaling in NK cells
	Immune response MIF-mediated glucocorticoid regulation
	Immune response IL-1 signaling pathway
	Transcription Role of VDR in regulation of genes involved in osteoporosis

5 R&D Systems Pathways for FOS

	Inflammasome Activation Pathways
	Adipocytokines & Insulin Signaling
	Th1 Differentiation
	Toll-Like receptor Signaling Pathways
	TGF-beta Signaling Pathways

5/82 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FOS (see all 82)

	UVB-Induced MAPK Signaling
	Molecular Mechanisms of Cancer
	ERK5 Signaling
	UVA-Induced MAPK Signaling
	PACAP Signaling

2 Cell Signaling Technology (CST) Pathways for FOS

	MAP Kinase Signaling
	Cell Cycle / Checkpoint Control

1 Tocris Bioscience Pathway for FOS

MAPK Pathway

5/43 GeneGo (Thomson Reuters) Pathways for FOS (see all 43)

	Development CNTF receptor signaling
	Development EGFR signaling pathway
	Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
	Development VEGF-family signaling
	Development PDGF signaling via STATs and NF-kB

5/47 BioSystems Pathways for FOS (see all 47)

	Estrogen signaling pathway
	Selenium Metabolism and Selenoproteins
	Myometrial Relaxation and Contraction Pathways
	Oncostatin M Signaling Pathway
	MAPK signaling pathway

5/23 Reactome Pathways for FOS (see all 23)

	Toll Like Receptor 2 (TLR2) Cascade
	Toll Like Receptor TLR6:TLR2 Cascade
	Toll-Like Receptors Cascades
	TRAF6 Mediated Induction of proinflammatory cytokines
	Toll Like Receptor 7/8 (TLR7/8) Cascade

2 PharmGKB Pathways for FOS

	EGFR Inhibitor Pathway, Pharmacodynamics
	Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

5/12 Kegg Pathways (Kegg details for FOS) (see all 12):

	MAPK signaling pathway
	Osteoclast differentiation
	Toll-like receptor signaling pathway
	T cell receptor signaling pathway
	B cell receptor signaling pathway

FOS for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FOS

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/293 Interacting proteins for FOS (P01100^{1, 2, 3} ENSP00000306245⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 293)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
JUN	P05412¹^,²^,³, ENSP00000360266⁴	EBI-852851,EBI-852823 MINT-8077940 MINT-8077771 MINT-8077923 MINT-68804 MINT-8077906 MINT-8077789 MINT-8077872 MINT-8077889 MINT-8077856 MINT-8077649 MINT-8077677 MINT-8077831 MINT-8077811 I2D: score=13 STRING: ENSP00000360266
JUND	P17535¹^,³, ENSP00000252818⁴	EBI-852851,EBI-2682803 I2D: score=6 STRING: ENSP00000252818
APP	P05067¹^,³, ENSP00000284981⁴	EBI-852851,EBI-77613 I2D: score=1 STRING: ENSP00000284981
CLU	P10909¹^,³, ENSP00000315130⁴	EBI-852851,EBI-1104674 I2D: score=1 STRING: ENSP00000315130
COPS4	Q9BT78¹^,³	EBI-852851,EBI-742413 I2D: score=1

About this table

Gene Ontology (GO): 5/43 biological process terms (GO ID links to tree view) (see all 43): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001661	conditioned taste aversion	IEA	--
GO:0002224	toll-like receptor signaling pathway	TAS	--
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	TAS	--
GO:0002756	MyD88-independent toll-like receptor signaling pathway	TAS	--
GO:0006306	DNA methylation	TAS	9888853

FOS for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FOS for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FOS

1 DrugBank Compound for FOS About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Nadroparin	--	9041-08-1	target	inhibitor	19261492 19757196

10/138 Novoseek chemical compound relationships for FOS gene (see all 138) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
12-o-tetradecanoylphorbol 13-acetate	73.6	155	10535756 (5), 1939341 (4), 1905005 (4), 1901945 (3) (see all 69)
tyrosine	69.4	174	8896447 (3), 9476581 (3), 10849652 (3), 9113418 (3) (see all 99)
pyroglutamyl-histidyl-glycine	67.1	1	12820376 (1)
pd 98,059	66.7	53	10648884 (3), 17424890 (2), 11208903 (1), 19349923 (1) (see all 45)
phorbol	66.4	27	9191080 (2), 8063733 (1), 1939341 (1), 1470918 (1) (see all 21)
cycloheximide	62.9	54	8115044 (3), 8544401 (2), 8764176 (2), 17257889 (1) (see all 36)
cyclic amp	58.6	125	7617161 (9), 11208903 (6), 11850128 (6), 1703775 (6) (see all 54)
thymidine	58.6	47	8078487 (3), 10374349 (2), 1517237 (2), 11834522 (2) (see all 39)
leucine	58.3	102	1901988 (4), 1739975 (4), 2113670 (4), 2133107 (2) (see all 61)
viphyb	55.9	1	10670826 (1)

Search CenterWatch for drugs/clinical trials and news about FOS

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FOS gene:

NM_005252.3

Unigene Cluster for FOS:

FBJ murine osteosarcoma viral oncogene homolog

Hs.731317 [show with all ESTs]

Unigene Representative Sequence: NM_005252

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000303562(uc001xrn.3 uc010tva.2 uc010asi.3) ENST00000554617

ENST00000556324 ENST00000554212 ENST00000535987 ENST00000555242 ENST00000555686

ENST00000555672 ENST00000557139 ENST00000555347

miRNA Products:		OriGene 3'-UTR Clone: FOS Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FOS
		8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate FOS (see all 45):
		hsa-miR-199a-3p hsa-miR-139-5p hsa-miR-29a hsa-miR-4267 hsa-miR-1244 hsa-miR-383 hsa-miR-155 hsa-miR-3148

		SwitchGear 3'UTR luciferase reporter plasmid: FOS 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOS (see all 7) OriGene shRNA RFP: FOS OriGene siRNA: FOS
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOS

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOS (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOS OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FOS (NM_005252)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FOS
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOS

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOS Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FOS
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOS
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOS

Additional cDNA sequence:

AK097379.1 AK290907.1 AK291326.1 AK298659.1 BC004490.2 BX647104.1 CR541785.1 CR542267.1

24/59 DOTS entries (see all 59):

DT.75190910 DT.92454956 DT.120026 DT.92368522 DT.100878506 DT.120794342 DT.120794307 DT.120794385

DT.120794350 DT.120794371 DT.95295078 DT.100878521 DT.97826657 DT.100760490 DT.120794344 DT.120794362

DT.120794320 DT.120794349 DT.92454959 DT.100878503 DT.91886249 DT.95295140 DT.100878517 DT.120794287

24/783 AceView cDNA sequences (see all 783):

BM742157 BG925313 BF477592 BU617636 CA414336 BM993176 CN480148 AW768483

CA406188 CA392839 CD678804 CR612516 BQ002675 F01912 D57772 CA427750

CD512907 BQ717306 BP373616 BM894421 BQ181351 CA413754 S65138 BI910688

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for FOS (see all 7) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	·	2d	·	2e	^	3	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	·	6e
SP1:					-		-						-								-
SP2:					-		-														-
SP3:					-		-								-		-				-
SP4:					-		-		-
SP5:					-		-

ECgene alternative splicing isoforms for FOS

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FOS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGAAAGTGA

About this image

FOS expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Cartilage

Cervical Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Sacral Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Thoracic Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Kidney

Thoracic Ventrolateral Dermomyotome Lip

Muscle Progenitor Cells

Skeletal Muscle

Testis

Seminiferous Tubules

Sertoli cells

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Secondary follicles (Primary Cell)

Ovary, Reproductive System

Nkx2-1 GFP+ cells (Efficient derivation...)

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

See FOS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FOS

SOURCE GeneReport for Unigene cluster: Hs.731317

SABiosciences Expression via Pathway-Focused PCR Arrays including FOS (see all 29):

Insulin Signaling Pathway in human mouse rat

HIV Host Response in human mouse rat

Stem Cell Transcription Factors in human mouse rat

Antiviral Response in human mouse rat

TGFB/BMP Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOS Browse OriGene validated miRNA SYBR primer pairs
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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOS

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FOS gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FOS¹	FBJ murine osteosarcoma viral oncogene homolog	76.7(n) 80.39(a)		396512 NM_205508.1 NP_990839.1
lizard (Anolis carolinensis)	Reptilia	FOS⁶	--	69(a)	1 ↔ 1	1(22458134-22462052)
African clawed frog (Xenopus laevis)	Amphibia	BX851015.1²	--	76.75(n)		BX851015.1
zebrafish (Danio rerio)	Actinopterygii	fos²	v-fos FBJ murine osteosarcoma viral oncogene homolog	76.11(n)		394198 CA787334.1
fruit fly (Drosophila melanogaster)	Insecta	kay⁶	kayak	10(a)	1 → many	3R(25592497-25619838)

ENSEMBL Gene Tree for FOS (if available)
TreeFam Gene Tree for FOS (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FOS gene

FOSL1² JDP2² ATF3² FOSB² FOSL2²

6 SIMAP similar genes for FOS using alignment to 10 protein entries: FOS_HUMAN (see all proteins):

ATF3 JDP2 FOSL2 FOSB BATF3 BATF

FOS for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10142078^1,2	C,H,	--	55912121(+)	`GCCCAG/TTTCCA`	1	--	us2k¹		4		NS EA	418
rs4645847^1,2	C,	--	55913023(+)	`AGACAC/ACCCCT`	1	--	us2k¹		1		NS	158
rs4645848^1,2	C,	--	55913056(+)	`TTTGCA/CCAGTG`	1	--	us2k¹		2		NS NA	284
rs4645849^1,2	C,F,	--	55913479(+)	`CCATCC/GCCCCC`	1	--	us2k¹		1		NS	168
rs4645850^1,2	C,F,	--	55913482(+)	`TCCCCC/ACCGAC`	1	--	us2k¹		8		NS NA	946
rs2234706^1,2	C,F,	--	55913737(+)	`ACCCCC/G/TCATCT`	1	--	us2k¹		8		NS MN EA NA CSA WA	1772
rs4645851^1,2	C,	--	55913774(+)	`AGGAAC/ATGCGA`	1	--	us2k¹		2		NS NA	262
rs4645852^1,2	C,F,H,	--	55913890(+)	`TCTGGC/AGCCAC`	1	--	us2k¹		6		NS NA	926
rs78326384^1,2	C	--	55914202(-)	`GGCTAA/TCCCCG`	2	D V	mis¹		0	--	--	--	--
rs4645853^1,2	C,F,	--	55914337(+)	`GGCGGG/AACGCT`	1	--	int¹		1		NS	158

HapMap Linkage Disequilibrium report for FOS (75745477 - 75748937 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FOS: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOS

DNA2.0 Custom Variant and Variant Library Synthesis for FOS

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FOS for disorders           About GeneDecksing

OMIM gene information: 164810    OMIM disorders: --

20/194 diseases for FOS (see all 194):    About MalaCards

fibrodysplasia ossificans progressiva coffin-lowry syndrome osteosarcoma estrogen-receptor negative breast cancer

splenic marginal zone lymphoma spinal cord injury human t-cell leukemia virus type 1 sudden infant death syndrome

attention deficit hyperactivity disorder transient cerebral ischemia non-small cell lung carcinoma cutis laxa

motion sickness clostridium difficile interleukin receptor traumatic brain injury

myositis ossificans fibrous dysplasia familial medullary thyroid carcinoma status epilepticus

13 diseases from the University of Copenhagen DISEASES database for FOS:

Cancer Vascular disease Pain agnosia Cholera

Schizophrenia Morphine dependence Migraine Withdrawal disorder

Eye disease Toxic encephalopathy Parkinson's disease Arthritis

Gastrointestinal system disease

10/91 Novoseek disease relationships for FOS gene (see all 91) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	46.7	255	15514944 (3), 1348920 (3), 8491516 (3), 11488520 (3) (see all 99)
leukemia t-cell	45	4	1916630 (1), 7732661 (1), 11145887 (1), 8361755 (1)
retinoblastoma	44.1	32	8872049 (3), 9364216 (3), 1652755 (1), 10757447 (1) (see all 21)
neoplastic transformation	37.6	4	8872049 (1), 9111306 (1), 18757399 (1), 17957143 (1)
osteosarcoma	36.6	46	9778623 (3), 9672192 (3), 11398843 (3), 7576109 (2) (see all 25)
breast cancer	36.5	66	16027729 (5), 15090535 (4), 7657391 (3), 8206948 (2) (see all 43)
myeloid leukemia	34	6	1939341 (2), 8462021 (1), 1732724 (1), 8404639 (1) (see all 5)
hyperalgesia	32.1	19	10082899 (4), 10082898 (3), 16522746 (2), 14622822 (2) (see all 11)
necrosis	30.2	44	8491516 (3), 8063765 (2), 10873159 (1), 19026727 (1) (see all 37)
teratocarcinoma	27.1	2	11402055 (1), 2157182 (1)

Genetic Association Database (GAD): FOS
Human Genome Epidemiology (HuGE) Navigator: FOS (27 documents)
Tumor Gene Database (TGDB): FOS

Export disorders for FOS gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FOS gene, integrated from 9 sources (see all 2794):
(articles sorted by number of sources associating them with FOS)

Utopia: connect your pdf to the dynamic
world of online information

Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation. (PubMed id 16055710)^{1, 2, 3, 9} Bossis G....Piechaczyk M. (2005)
Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1. (PubMed id 16123044)^{1, 3, 9} Monje P....Gutkind J.S. (2005)
Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation. (PubMed id 17709345)^{1, 2} Jakobs A.... Niedenthal R. (2007)
The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PubMed id 17203973)^{1, 2} Vasilescu J.... Figeys D. (2007)
Forebrain patterns of c-Fos and FosB induction during cancer-associated anorexia-cachexia in rat. (PubMed id 15926923)^{1, 3} Konsman J.P. and Blomqvist A. (2005)
LRP5, low-density-lipoprotein-receptor-related protein 5, is a determinant for bone mineral density. (PubMed id 14727154)^{1, 4} Mizuguchi T.... Yoshiura K. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)^{1, 2} Heilig R.... Weissenbach J. (2003)
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. (PubMed id 9732876)^{1, 2} Zhang Y....Derynck R. (1998)
Crystal structure of the heterodimeric bZIP transcription factor c- Fos-c-Jun bound to DNA. (PubMed id 7816143)^{1, 2} Glover J.N. and Harrison S.C. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2353	HGNC: 3796	AceView: FOS	Ensembl:ENSG00000170345	euGenes: HUgn2353
ECgene: FOS	Kegg: 2353	H-InvDB: FOS

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FOS	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FOS	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/fos/

Intellectual Property for FOS gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FOS gene:
Search GeneIP for patents involving FOS

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

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FOS Gene

FBJ murine osteosarcoma viral oncogene homolog

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Leukemia T-Cell
Retinoblastoma
Scars Hypertrophic
MICROPHTHALMIA
Colitis Ulcerative
COLON CARCINOMA
LUNG CARCINOMA
Bone Diseases
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Breast Cancer
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Edema
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Cancer
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Proteinuria
Monocytic leukemia
Stress Disorders Posttraumatic
immunodeficiency
Hypertrophy
Hepatitis B
LIVER DAMAGE
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prostate cancer
Tumors
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Mental Retardation
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prostatic adenocarcinoma
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major depression
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chronic pancreatitis
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OVARIAN CARCINOMA
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Fibrodysplasia Ossificans Progressiva
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FOS Gene

FBJ murine osteosarcoma viral oncogene homolog

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