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Aliases for FOS Gene

Aliases for FOS Gene

  • FBJ Murine Osteosarcoma Viral Oncogene Homolog 2 3 5
  • G0/G1 Switch Regulatory Protein 7 3 4
  • FBJ Murine Osteosarcoma Viral (V-Fos) Oncogene Homolog (Oncogene FOS) 3
  • V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog 2
  • Cellular Oncogene C-Fos 3
  • Cellular Oncogene Fos 4
  • Activator Protein 1 3
  • C-FOS 3
  • AP-1 3
  • G0S7 4
  • P55 3

External Ids for FOS Gene

Previous GeneCards Identifiers for FOS Gene

  • GC14P073251
  • GC14P069562
  • GC14P073735
  • GC14P074815
  • GC14P075745
  • GC14P055913

Summaries for FOS Gene

Entrez Gene Summary for FOS Gene

  • The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOS Gene

FOS (FBJ Murine Osteosarcoma Viral Oncogene Homolog) is a Protein Coding gene. Diseases associated with FOS include myositis ossificans and cerebral hypoxia. Among its related pathways are Gene Expression and IL6-mediated signaling events. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is FOSL1.

UniProtKB/Swiss-Prot for FOS Gene

  • Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

Gene Wiki entry for FOS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOS Gene

Genomics for FOS Gene

Regulatory Elements for FOS Gene

Promoters for FOS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FOS on UCSC Golden Path with GeneCards custom track

Genomic Location for FOS Gene

Chromosome:
14
Start:
75,278,774 bp from pter
End:
75,282,234 bp from pter
Size:
3,461 bases
Orientation:
Plus strand

Genomic View for FOS Gene

Genes around FOS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOS Gene

Proteins for FOS Gene

  • Protein details for FOS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01100-FOS_HUMAN
    Recommended name:
    Proto-oncogene c-Fos
    Protein Accession:
    P01100
    Secondary Accessions:
    • A8K4E2
    • B4DQ65
    • P18849

    Protein attributes for FOS Gene

    Size:
    380 amino acids
    Molecular mass:
    40695 Da
    Quaternary structure:
    • Heterodimer; with JUN (By similarity). Interacts with MAFB (By similarity). Component of the SMAD3/SMAD4/JUN/FOS complex required for synergistic TGF-beta-mediated transcription at the AP1 promoter site. Interacts with SMAD3; the interaction is weak even on TGF-beta activation. Interacts with MAFB. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with CDS1 and PI4K2A (By similarity).

    Three dimensional structures from OCA and Proteopedia for FOS Gene

    Alternative splice isoforms for FOS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOS Gene

Proteomics data for FOS Gene at MOPED

Post-translational modifications for FOS Gene

  • Constitutively sumoylated with SUMO1, SUMO2 and SUMO3. Desumoylated by SENP2. Sumoylation requires heterodimerization with JUN and is enhanced by mitogen stimulation. Sumoylation inhibits the AP-1 transcriptional activity and is, itself, inhibited by Ras-activated phosphorylation on Thr-232.
  • In quiescent cells, the small amount of FOS present is phosphorylated at Tyr-10 and Tyr-30 by SRC. This Tyr-phosphorylated form is cytosolic. In growing cells, dephosphorylated by PTPN2. Dephosphorylation leads to the association with endoplasmic reticulum membranes and activation of phospholipid synthesis.
  • Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth factor (EGF). Phosphorylated, in vitro, by MAPK and RSK1. Phosphorylation on both Ser-362 and Ser-374 by MAPK1/2 and RSK1/2 leads to protein stabilization with phosphorylation on Ser-374 being the major site for protein stabilization on NGF stimulation. Phosphorylation on Ser-362 and Ser-374 primes further phosphorylations on Thr-325 and Thr-331 through promoting docking of MAPK to the DEF domain. Phosphorylation on Thr-232, induced by HA-RAS, activates the transcriptional activity and antagonizes sumoylation. Phosphorylation on Ser-362 by RSK2 in osteoblasts contributes to osteoblast transformation (By similarity).
  • Ubiquitination at Lys 113
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FOS Gene

Domains & Families for FOS Gene

Protein Domains for FOS Gene

Graphical View of Domain Structure for InterPro Entry

P01100

UniProtKB/Swiss-Prot:

FOS_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. Fos subfamily.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. Fos subfamily.
genes like me logo Genes that share domains with FOS: view

Function for FOS Gene

Molecular function for FOS Gene

GENATLAS Biochemistry:
murine FBJ osteosarcoma viral (v-fos) oncogene homolog,ligand induced,immediate (primary) early response gene
UniProtKB/Swiss-Prot Function:
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

Gene Ontology (GO) - Molecular Function for FOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOS: view
genes like me logo Genes that share phenotypes with FOS: view

Human Phenotype Ontology for FOS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FOS Gene

MGI Knock Outs for FOS:

Animal Model Products

miRNA for FOS Gene

miRTarBase miRNAs that target FOS

Transcription Factor Targets for FOS Gene

Selected GeneGlobe predicted Target genes for FOS
Targeted motifs for FOS Gene
HOMER Transcription Factor Regulatory Elements motif FOS
  • Consensus sequence: ATGACTCATC Submotif: canonical Cell Type: ThioMac GEO ID: GSE21512

No data available for Enzyme Numbers (IUBMB) for FOS Gene

Localization for FOS Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOS Gene

Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOS Gene COMPARTMENTS Subcellular localization image for FOS gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
nucleus 5
cytoskeleton 2
extracellular 2
mitochondrion 2
plasma membrane 2
endosome 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with FOS: view

Pathways & Interactions for FOS Gene

SuperPathways for FOS Gene

Superpath Contained pathways
1 MyD88 cascade initiated on plasma membrane
2 IL-2 Pathway
3 Toll-Like receptor Signaling Pathways
4 Development Angiotensin activation of ERK
5 ERK Signaling
genes like me logo Genes that share pathways with FOS: view

Pathways by source for FOS Gene

SIGNOR curated interactions for FOS Gene

Is activated by:

Gene Ontology (GO) - Biological Process for FOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006306 DNA methylation TAS 9888853
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA,TAS 10918580
genes like me logo Genes that share ontologies with FOS: view

Drugs & Compounds for FOS Gene

(66) Drugs for FOS Gene - From: Novoseek, DrugBank, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nadroparin Approved Pharma Target, inhibitor 32
Pseudoephedrine Approved Pharma Target 447
Inulin Approved Nutra 95
Proton pump inhibitors Pharma 958

(79) Additional Compounds for FOS Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
c-JUN peptide
610273-01-3
SP 100030
154563-54-9
SR 11302
160162-42-5
genes like me logo Genes that share compounds with FOS: view

Transcripts for FOS Gene

Unigene Clusters for FOS Gene

FBJ murine osteosarcoma viral oncogene homolog:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOS Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: -
SP7: - - -

Relevant External Links for FOS Gene

GeneLoc Exon Structure for
FOS
ECgene alternative splicing isoforms for
FOS

Expression for FOS Gene

mRNA expression in normal human tissues for FOS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOS Gene

This gene is overexpressed in Fallopian Tube (x7.2).

Protein differential expression in normal tissues from HIPED for FOS Gene

This gene is overexpressed in Monocytes (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FOS Gene



SOURCE GeneReport for Unigene cluster for FOS Gene Hs.25647

genes like me logo Genes that share expression patterns with FOS: view

Protein tissue co-expression partners for FOS Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FOS Gene

Orthologs for FOS Gene

This gene was present in the common ancestor of animals.

Orthologs for FOS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOS 35
  • 99.65 (n)
  • 99.74 (a)
C-FOS 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FOS 36
  • 96 (a)
OneToOne
FOS 35
  • 92.11 (n)
  • 96.32 (a)
dog
(Canis familiaris)
Mammalia FOS 35
  • 92.28 (n)
  • 97.11 (a)
FOS 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fos 16
Fos 35
  • 88.33 (n)
  • 93.68 (a)
Fos 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOS 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOS 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fos 35
  • 88.51 (n)
  • 94.21 (a)
chicken
(Gallus gallus)
Aves FOS 35
  • 76.7 (n)
  • 80.11 (a)
FOS 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOS 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fos 35
  • 66.02 (n)
  • 69.06 (a)
Str.20514 35
zebrafish
(Danio rerio)
Actinopterygii fos 36
  • 59 (a)
OneToMany
FOS (2 of 3) 36
  • 45 (a)
OneToMany
FOS (3 of 3) 36
  • 35 (a)
OneToMany
fos 35
  • 61.82 (n)
  • 61.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta kay 36
  • 14 (a)
OneToMany
Species with no ortholog for FOS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOS Gene

ENSEMBL:
Gene Tree for FOS (if available)
TreeFam:
Gene Tree for FOS (if available)

Paralogs for FOS Gene

Paralogs for FOS Gene

genes like me logo Genes that share paralogs with FOS: view

Variants for FOS Gene

Sequence variations from dbSNP and Humsavar for FOS Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs14371 -- 75,282,090(-) atCTG(A/G)GAATC utr-variant-3-prime
rs1046117 -- 75,279,987(+) TCCTC(C/T)GTGGC reference, synonymous-codon
rs1046283 -- 75,281,565(+) CCAGG(C/G)TGTGG utr-variant-3-prime
rs2234706 -- 75,278,591(+) ACCCC(C/G/T)CATCT upstream-variant-2KB
rs2239615 -- 75,278,848(+) GAGCA(A/T)CTGAG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FOS Gene

Variant ID Type Subtype PubMed ID
nsv832833 CNV Gain 17160897

Variation tolerance for FOS Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOS Gene

HapMap Linkage Disequilibrium report
FOS
Human Gene Mutation Database (HGMD)
FOS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOS Gene

Disorders for FOS Gene

MalaCards: The human disease database

(53) MalaCards diseases for FOS Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myositis ossificans
  • myisitis ossificans
cerebral hypoxia
  • brain hypoxia
pertussis
  • bordetella infection
fibrodysplasia ossificans progressiva
  • myositis ossificans progressiva
acute pericementitis
  • acute periodontitis
- elite association - COSMIC cancer census association via MalaCards
Search FOS in MalaCards View complete list of genes associated with diseases

Relevant External Links for FOS

Genetic Association Database (GAD)
FOS
Human Genome Epidemiology (HuGE) Navigator
FOS
Tumor Gene Database (TGDB):
FOS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOS
genes like me logo Genes that share disorders with FOS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOS Gene

Publications for FOS Gene

  1. Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation. (PMID: 16055710) Bossis G. … Piechaczyk M. (Mol. Cell. Biol. 2005) 2 3 4 23 67
  2. Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1. (PMID: 16123044) Monje P. … Gutkind J.S. (J. Biol. Chem. 2005) 2 3 23
  3. Expression of the proto-oncogene c-fos and the immunolocalization of c-fos, phosphorylated c-fos and estrogen receptor beta in the human testis. (PMID: 19795350) AraA_jo F.C. … Reis F.M. (Histol. Histopathol. 2009) 3 23
  4. c-fos gene and protein expression in pelvic endometriosis: a local marker of estrogen action. (PMID: 19199093) Morsch D.M. … Spritzer P.M. (J. Mol. Histol. 2009) 3 23
  5. c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1. (PMID: 19009649) GA1ller M. … Daniel F. (World J. Gastroenterol. 2008) 3 23

Products for FOS Gene

Sources for FOS Gene

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