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Aliases for FOPNL Gene

Aliases for FOPNL Gene

  • FGFR1OP N-Terminal Like 2 3
  • FOP-Related Protein Of 20 KDa 2 3 4
  • Pluripotent Embryonic Stem Cell-Related Protein 2 3
  • C16orf63 3 4
  • PHSECRG2 3 4
  • FOR20 3 4
  • LisH Domain-Containing Protein C16orf63 3
  • LisH Domain-Containing Protein FOPNL 3
  • Chromosome 16 Open Reading Frame 63 2
  • FGFR1OP N-Terminal-Like Protein 4

External Ids for FOPNL Gene

Previous HGNC Symbols for FOPNL Gene

  • C16orf63

Previous GeneCards Identifiers for FOPNL Gene

  • GC16M015959

Summaries for FOPNL Gene

GeneCards Summary for FOPNL Gene

FOPNL (FGFR1OP N-Terminal Like) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FOPNL Gene

  • Involved in the biogenesis of cilia.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOPNL Gene

Genomics for FOPNL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FOPNL Gene

15,865,719 bp from pter
15,888,625 bp from pter
22,907 bases
Minus strand

Genomic View for FOPNL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOPNL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOPNL Gene

No data available for Regulatory Elements for FOPNL Gene

Proteins for FOPNL Gene

  • Protein details for FOPNL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    LisH domain-containing protein FOPNL
    Protein Accession:
    Secondary Accessions:
    • B3KPU9

    Protein attributes for FOPNL Gene

    174 amino acids
    Molecular mass:
    19778 Da
    Quaternary structure:
    • Homooligomer; probably required for localization to centrosomes

    Alternative splice isoforms for FOPNL Gene


neXtProt entry for FOPNL Gene

Proteomics data for FOPNL Gene at MOPED

Post-translational modifications for FOPNL Gene

  • Ubiquitination at Lys8
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FOPNL Gene

Domains for FOPNL Gene

Protein Domains for FOPNL Gene

Suggested Antigen Peptide Sequences for FOPNL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96NB1
  • Contains 1 LisH domain.
  • Belongs to the FGFR1OP family.
genes like me logo Genes that share domains with FOPNL: view

No data available for Gene Families for FOPNL Gene

Function for FOPNL Gene

Molecular function for FOPNL Gene

UniProtKB/Swiss-Prot Function: Involved in the biogenesis of cilia.

Gene Ontology (GO) - Molecular Function for FOPNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FOPNL: view

Phenotypes for FOPNL Gene

genes like me logo Genes that share phenotypes with FOPNL: view

Animal Model Products

CRISPR Products

miRNA for FOPNL Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOPNL

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FOPNL Gene

Localization for FOPNL Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOPNL Gene

Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.

Gene Ontology (GO) - Cellular Components for FOPNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005813 centrosome IDA --
GO:0005815 microtubule organizing center --
GO:0031514 motile cilium ISS --
GO:0034451 centriolar satellite IDA 15616553
genes like me logo Genes that share ontologies with FOPNL: view

No data available for Subcellular locations from COMPARTMENTS for FOPNL Gene

Pathways for FOPNL Gene

SuperPathways for FOPNL Gene

No Data Available

Interacting Proteins for FOPNL Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000255759 Q96NB1-FOPNL_HUMAN for FOPNL Gene via STRING I2D

Gene Ontology (GO) - Biological Process for FOPNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034453 microtubule anchoring IEA --
GO:0042384 cilium assembly IMP 15616553
genes like me logo Genes that share ontologies with FOPNL: view

No data available for Pathways by source for FOPNL Gene

Transcripts for FOPNL Gene

Unigene Clusters for FOPNL Gene

FGFR1OP N-terminal like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOPNL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOPNL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - -
SP2: -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for FOPNL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FOPNL Gene

mRNA expression in normal human tissues for FOPNL Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FOPNL Gene

SOURCE GeneReport for Unigene cluster for FOPNL Gene Hs.514179

mRNA Expression by UniProt/SwissProt for FOPNL Gene

Tissue specificity: Widely expressed. Detected in brain, heart, kidney, liver, lung, skeletal muscle, placenta and intestine.
genes like me logo Genes that share expressions with FOPNL: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FOPNL Gene

Orthologs for FOPNL Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOPNL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FOPNL 36
  • 100 (a)
(Bos Taurus)
Mammalia FOPNL 35
  • 85.63 (n)
  • 82.76 (a)
  • 83 (a)
(Canis familiaris)
Mammalia FOPNL 35
  • 87.55 (n)
  • 82.18 (a)
  • 82 (a)
(Mus musculus)
Mammalia Fopnl 35
  • 81.7 (n)
  • 79.77 (a)
Fopnl 16
Fopnl 36
  • 79 (a)
(Monodelphis domestica)
Mammalia FOPNL 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia FOPNL 36
  • 77 (a)
(Rattus norvegicus)
Mammalia Fopnl 35
  • 82.47 (n)
  • 78.61 (a)
(Gallus gallus)
Aves FOPNL 35
  • 65.9 (n)
  • 58.62 (a)
  • 58 (a)
(Anolis carolinensis)
Reptilia FOPNL 36
  • 46 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7611 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fopnl 35
  • 64.46 (n)
  • 66.94 (a)
Str.3182 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14123 35
(Danio rerio)
Actinopterygii fopnl 35
  • 59.95 (n)
  • 66.67 (a)
fopnl 36
  • 59 (a)
Species with no ortholog for FOPNL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOPNL Gene

Gene Tree for FOPNL (if available)
Gene Tree for FOPNL (if available)

Paralogs for FOPNL Gene

genes like me logo Genes that share paralogs with FOPNL: view

No data available for Paralogs for FOPNL Gene

Variants for FOPNL Gene

Sequence variations from dbSNP and Humsavar for FOPNL Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs11129 -- 15,865,919(+) TGATT(G/T)CAATT utr-variant-3-prime
rs11642 -- 15,865,772(+) TTGCC(A/G)CAGTA utr-variant-3-prime
rs15784 -- 15,867,494(+) TTCTG(C/T)TCCTC utr-variant-3-prime, reference, synonymous-codon
rs188575 -- 15,868,032(+) CTAAT(A/T)ATTCA intron-variant
rs215562 -- 15,875,962(+) gtgtg(C/G)tggca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOPNL Gene

Variant ID Type Subtype PubMed ID
nsv435664 CNV Deletion 17901297
esv2714015 CNV Deletion 23290073
nsv457428 CNV Gain 19166990
dgv2614n71 CNV Gain 21882294
nsv833149 CNV Loss 17160897
nsv905402 CNV Gain 21882294
nsv471085 CNV Gain 18288195
dgv2615n71 CNV Gain 21882294
esv23840 CNV Gain+Loss 19812545
esv2421345 CNV Duplication 20811451
dgv345n27 CNV Gain 19166990
nsv514795 CNV Gain 21397061
nsv457432 CNV Gain 19166990
nsv457436 CNV Gain 19166990
nsv442391 CNV CNV 18776908

Relevant External Links for FOPNL Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOPNL Gene

Disorders for FOPNL Gene

No disorders were found for FOPNL Gene.

No data available for UniProtKB/Swiss-Prot for FOPNL Gene

Publications for FOPNL Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4
  5. Control of ciliogenesis by FOR20, a novel centrosome and pericentriolar satellite protein. (PMID: 20551181) Sedjai F. … Rosnet O. (J. Cell Sci. 2010) 3 4

Products for FOPNL Gene

Sources for FOPNL Gene

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