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Aliases for FOPNL Gene

Aliases for FOPNL Gene

  • FGFR1OP N-Terminal Like 2 3 5
  • FOP-Related Protein Of 20 KDa 2 3 4
  • Pluripotent Embryonic Stem Cell-Related Protein 2 3
  • C16orf63 3 4
  • PHSECRG2 3 4
  • FOR20 3 4
  • LisH Domain-Containing Protein C16orf63 3
  • Chromosome 16 Open Reading Frame 63 2
  • FGFR1OP N-Terminal-Like Protein 4

External Ids for FOPNL Gene

Previous HGNC Symbols for FOPNL Gene

  • C16orf63

Previous GeneCards Identifiers for FOPNL Gene

  • GC16M015959

Summaries for FOPNL Gene

GeneCards Summary for FOPNL Gene

FOPNL (FGFR1OP N-Terminal Like) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FOPNL Gene

  • Involved in the biogenesis of cilia.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOPNL Gene

Genomics for FOPNL Gene

Regulatory Elements for FOPNL Gene

Enhancers for FOPNL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FOPNL on UCSC Golden Path with GeneCards custom track

Promoters for FOPNL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FOPNL on UCSC Golden Path with GeneCards custom track

Genomic Location for FOPNL Gene

Chromosome:
16
Start:
15,865,719 bp from pter
End:
15,888,649 bp from pter
Size:
22,931 bases
Orientation:
Minus strand

Genomic View for FOPNL Gene

Genes around FOPNL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOPNL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOPNL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOPNL Gene

Proteins for FOPNL Gene

  • Protein details for FOPNL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NB1-FOPNL_HUMAN
    Recommended name:
    LisH domain-containing protein FOPNL
    Protein Accession:
    Q96NB1
    Secondary Accessions:
    • B3KPU9

    Protein attributes for FOPNL Gene

    Size:
    174 amino acids
    Molecular mass:
    19778 Da
    Quaternary structure:
    • Homooligomer; probably required for localization to centrosomes.

    Alternative splice isoforms for FOPNL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOPNL Gene

Proteomics data for FOPNL Gene at MOPED

Post-translational modifications for FOPNL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FOPNL Gene

Domains & Families for FOPNL Gene

Protein Domains for FOPNL Gene

Suggested Antigen Peptide Sequences for FOPNL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96NB1

UniProtKB/Swiss-Prot:

FOPNL_HUMAN :
  • Contains 1 LisH domain.
  • Belongs to the FGFR1OP family.
Domain:
  • Contains 1 LisH domain.
Family:
  • Belongs to the FGFR1OP family.
genes like me logo Genes that share domains with FOPNL: view

No data available for Gene Families for FOPNL Gene

Function for FOPNL Gene

Molecular function for FOPNL Gene

UniProtKB/Swiss-Prot Function:
Involved in the biogenesis of cilia.
genes like me logo Genes that share phenotypes with FOPNL: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FOPNL Gene

Localization for FOPNL Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOPNL Gene

Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOPNL Gene COMPARTMENTS Subcellular localization image for FOPNL gene
Compartment Confidence
cytoskeleton 5
nucleus 5

Gene Ontology (GO) - Cellular Components for FOPNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005815 microtubule organizing center IEA --
GO:0031514 motile cilium IEA,ISS --
GO:0034451 centriolar satellite IDA 15616553
GO:0036064 ciliary basal body IEA,ISS --
genes like me logo Genes that share ontologies with FOPNL: view

Pathways & Interactions for FOPNL Gene

SuperPathways for FOPNL Gene

No Data Available

Interacting Proteins for FOPNL Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000255759%0d%0a9606.ENSP00000327077%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000255759 Q96NB1-FOPNL_HUMAN for FOPNL Gene via STRING I2D

Gene Ontology (GO) - Biological Process for FOPNL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FOPNL Gene

Drugs & Compounds for FOPNL Gene

No Compound Related Data Available

Transcripts for FOPNL Gene

Unigene Clusters for FOPNL Gene

FGFR1OP N-terminal like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOPNL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - -
SP2: -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for FOPNL Gene

GeneLoc Exon Structure for
FOPNL
ECgene alternative splicing isoforms for
FOPNL

Expression for FOPNL Gene

mRNA expression in normal human tissues for FOPNL Gene

Protein differential expression in normal tissues from HIPED for FOPNL Gene

This gene is overexpressed in CD8 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FOPNL Gene



SOURCE GeneReport for Unigene cluster for FOPNL Gene Hs.514179

mRNA Expression by UniProt/SwissProt for FOPNL Gene

Q96NB1-FOPNL_HUMAN
Tissue specificity: Widely expressed. Detected in brain, heart, kidney, liver, lung, skeletal muscle, placenta and intestine.
genes like me logo Genes that share expression patterns with FOPNL: view

Protein tissue co-expression partners for FOPNL Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FOPNL Gene

Orthologs for FOPNL Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOPNL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOPNL 35
  • 85.63 (n)
  • 82.76 (a)
FOPNL 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOPNL 35
  • 87.55 (n)
  • 82.18 (a)
FOPNL 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fopnl 35
  • 81.7 (n)
  • 79.77 (a)
Fopnl 16
Fopnl 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fopnl 35
  • 82.47 (n)
  • 78.61 (a)
oppossum
(Monodelphis domestica)
Mammalia FOPNL 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOPNL 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOPNL 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOPNL 35
  • 65.9 (n)
  • 58.62 (a)
FOPNL 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOPNL 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fopnl 35
  • 64.46 (n)
  • 66.94 (a)
Str.3182 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7611 35
zebrafish
(Danio rerio)
Actinopterygii fopnl 35
  • 59.95 (n)
  • 66.67 (a)
fopnl 36
  • 59 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14123 35
Species with no ortholog for FOPNL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOPNL Gene

ENSEMBL:
Gene Tree for FOPNL (if available)
TreeFam:
Gene Tree for FOPNL (if available)

Paralogs for FOPNL Gene

genes like me logo Genes that share paralogs with FOPNL: view

No data available for Paralogs for FOPNL Gene

Variants for FOPNL Gene

Sequence variations from dbSNP and Humsavar for FOPNL Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs11129 -- 15,865,919(+) TGATT(G/T)CAATT nc-transcript-variant, utr-variant-3-prime
rs11642 -- 15,865,772(+) TTGCC(A/G)CAGTA nc-transcript-variant, utr-variant-3-prime
rs15784 -- 15,867,494(+) TTCTG(C/T)TCCTC nc-transcript-variant, reference, synonymous-codon, utr-variant-3-prime
rs4303510 -- 15,886,385(+) TTGTA(A/G)CAGGT intron-variant
rs188575 -- 15,868,032(+) CTAAT(A/T)ATTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOPNL Gene

Variant ID Type Subtype PubMed ID
nsv435664 CNV Deletion 17901297
esv2714015 CNV Deletion 23290073
nsv457428 CNV Gain 19166990
dgv2614n71 CNV Gain 21882294
nsv833149 CNV Loss 17160897
nsv905402 CNV Gain 21882294
nsv471085 CNV Gain 18288195
dgv2615n71 CNV Gain 21882294
esv23840 CNV Gain+Loss 19812545
esv2421345 CNV Duplication 20811451
dgv345n27 CNV Gain 19166990
nsv514795 CNV Gain 21397061
nsv457432 CNV Gain 19166990
nsv457436 CNV Gain 19166990
nsv442391 CNV CNV 18776908

Variation tolerance for FOPNL Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.45; 88.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FOPNL Gene

Disorders for FOPNL Gene

Relevant External Links for FOPNL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOPNL

No disorders were found for FOPNL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOPNL Gene

Publications for FOPNL Gene

  1. Control of ciliogenesis by FOR20, a novel centrosome and pericentriolar satellite protein. (PMID: 20551181) Sedjai F. … Rosnet O. (J. Cell Sci. 2010) 2 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  4. Centrosomal protein FOR20 is essential for S-phase progression by recruiting Plk1 to centrosomes. (PMID: 24018379) Shen M. … Zhou T. (Cell Res. 2013) 3
  5. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PMID: 21399614) Jakobsen L. … Andersen J.S. (EMBO J. 2011) 3

Products for FOPNL Gene

Sources for FOPNL Gene

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