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Aliases for FOPNL Gene

Aliases for FOPNL Gene

  • FGFR1OP N-Terminal Like 2 3 5
  • FOP-Related Protein Of 20 KDa 2 3 4
  • Pluripotent Embryonic Stem Cell-Related Protein 2 3
  • C16orf63 3 4
  • PHSECRG2 3 4
  • FOR20 3 4
  • LisH Domain-Containing Protein C16orf63 3
  • LisH Domain-Containing Protein FOPNL 3
  • Chromosome 16 Open Reading Frame 63 2
  • FGFR1OP N-Terminal-Like Protein 4

External Ids for FOPNL Gene

Previous HGNC Symbols for FOPNL Gene

  • C16orf63

Previous GeneCards Identifiers for FOPNL Gene

  • GC16M015959

Summaries for FOPNL Gene

GeneCards Summary for FOPNL Gene

FOPNL (FGFR1OP N-Terminal Like) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FOPNL Gene

  • Involved in the biogenesis of cilia.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOPNL Gene

Genomics for FOPNL Gene

Regulatory Elements for FOPNL Gene

Enhancers for FOPNL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F015884 1.4 FANTOM5 ENCODE 14.4 +1.6 1553 4.8 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 FOPNL RRN3 ENSG00000183889 ENSG00000183458 PKD1P1 NPIPA5 NDE1 ENSG00000262171
GH16F016018 1.7 FANTOM5 Ensembl ENCODE 11.8 -132.7 -132711 5.4 PKNOX1 ARNT MLX ARID4B SIN3A DMAP1 SLC30A9 CBX5 FOS DEK FOPNL RNU6-213P MYH11 ABCC1 GC16P016010 RPL17P40
GH16F015992 1.7 FANTOM5 Ensembl ENCODE 11.3 -108.3 -108265 8.6 MLX SIN3A ARID4B DMAP1 SLC30A9 FOS SP5 MXD4 KAT8 MEF2D ABCC1 ENSG00000183889 PKD1P1 RNU6-213P FOPNL LOC100505915 ENSG00000227827 NPIPA5 PKD1P6 NDE1
GH16F015970 1.6 FANTOM5 Ensembl ENCODE 11.4 -85.7 -85651 8.2 ZFP64 ETS1 CBX5 GATA2 ZNF143 FOS ZNF263 ZNF202 NFYC REST LOC100505915 PKD1P1 PKD1P6 ABCC1 RRN3 FOPNL NPIPA5 ENSG00000227827 NDE1 GC16P016010
GH16F015986 1.6 FANTOM5 Ensembl ENCODE 11.2 -100.0 -100004 4.2 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF302 FOS REST KAT8 SMARCA4 ABCC1 RPL17P40 ENSG00000263029 RNU6-213P FOPNL MYH11 ENSG00000263065 NDE1 GC16P016010
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FOPNL on UCSC Golden Path with GeneCards custom track

Promoters for FOPNL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FOPNL Gene

15,865,719 bp from pter
15,888,649 bp from pter
22,931 bases
Minus strand

Genomic View for FOPNL Gene

Genes around FOPNL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOPNL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOPNL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOPNL Gene

Proteins for FOPNL Gene

  • Protein details for FOPNL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    LisH domain-containing protein FOPNL
    Protein Accession:
    Secondary Accessions:
    • B3KPU9

    Protein attributes for FOPNL Gene

    174 amino acids
    Molecular mass:
    19778 Da
    Quaternary structure:
    • Homooligomer; probably required for localization to centrosomes.

    Alternative splice isoforms for FOPNL Gene


neXtProt entry for FOPNL Gene

Post-translational modifications for FOPNL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FOPNL Gene

Domains & Families for FOPNL Gene

Protein Domains for FOPNL Gene

Suggested Antigen Peptide Sequences for FOPNL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 LisH domain.
  • Belongs to the FGFR1OP family.
  • Contains 1 LisH domain.
  • Belongs to the FGFR1OP family.
genes like me logo Genes that share domains with FOPNL: view

No data available for Gene Families for FOPNL Gene

Function for FOPNL Gene

Molecular function for FOPNL Gene

UniProtKB/Swiss-Prot Function:
Involved in the biogenesis of cilia.
genes like me logo Genes that share phenotypes with FOPNL: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FOPNL Gene

Localization for FOPNL Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOPNL Gene

Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOPNL gene
Compartment Confidence
cytoskeleton 5
nucleus 5

Gene Ontology (GO) - Cellular Components for FOPNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with FOPNL: view

Pathways & Interactions for FOPNL Gene

SuperPathways for FOPNL Gene

No Data Available

Interacting Proteins for FOPNL Gene

Gene Ontology (GO) - Biological Process for FOPNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030030 cell projection organization IEA --
GO:0034453 microtubule anchoring IEA --
GO:0060271 cilium assembly IMP 15616553
genes like me logo Genes that share ontologies with FOPNL: view

No data available for Pathways by source and SIGNOR curated interactions for FOPNL Gene

Transcripts for FOPNL Gene

Unigene Clusters for FOPNL Gene

FGFR1OP N-terminal like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOPNL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - -
SP2: -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for FOPNL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FOPNL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOPNL Gene

Protein differential expression in normal tissues from HIPED for FOPNL Gene

This gene is overexpressed in CD8 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FOPNL Gene

Protein tissue co-expression partners for FOPNL Gene

NURSA nuclear receptor signaling pathways regulating expression of FOPNL Gene:


SOURCE GeneReport for Unigene cluster for FOPNL Gene:


mRNA Expression by UniProt/SwissProt for FOPNL Gene:

Tissue specificity: Widely expressed. Detected in brain, heart, kidney, liver, lung, skeletal muscle, placenta and intestine.
genes like me logo Genes that share expression patterns with FOPNL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FOPNL Gene

Orthologs for FOPNL Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOPNL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FOPNL 35
  • 100 (a)
(Canis familiaris)
Mammalia FOPNL 34 35
  • 87.55 (n)
(Bos Taurus)
Mammalia FOPNL 34 35
  • 85.63 (n)
(Rattus norvegicus)
Mammalia Fopnl 34
  • 82.47 (n)
(Mus musculus)
Mammalia Fopnl 34 16 35
  • 81.7 (n)
(Monodelphis domestica)
Mammalia FOPNL 35
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia FOPNL 35
  • 77 (a)
(Gallus gallus)
Aves FOPNL 34 35
  • 65.9 (n)
(Anolis carolinensis)
Reptilia FOPNL 35
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fopnl 34
  • 64.46 (n)
Str.3182 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7611 34
(Danio rerio)
Actinopterygii fopnl 34 35
  • 59.95 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14123 34
Species where no ortholog for FOPNL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOPNL Gene

Gene Tree for FOPNL (if available)
Gene Tree for FOPNL (if available)

Paralogs for FOPNL Gene

No data available for Paralogs for FOPNL Gene

Variants for FOPNL Gene

Sequence variations from dbSNP and Humsavar for FOPNL Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10451086 -- 15,884,799(+) GTGCC(C/T)GGCCA intron-variant
rs1048813 -- 15,865,836(-) GTTAA(A/G)CAGAA nc-transcript-variant, utr-variant-3-prime
rs1058365 -- 15,879,166(-) TACTA(G/T)TACTC intron-variant
rs10656021 -- 15,873,504(+) TTCTT(-/CTA)CTACT intron-variant, nc-transcript-variant, cds-indel
rs10656462 -- 15,879,530(+) TTAAA(-/AAAC)AAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOPNL Gene

Variant ID Type Subtype PubMed ID
dgv2773n100 CNV gain 25217958
dgv2774n100 CNV gain 25217958
dgv345n27 CNV gain 19166990
dgv4924n54 CNV gain 21841781
dgv4926n54 CNV gain 21841781
esv23840 CNV gain+loss 19812545
esv2421345 CNV duplication 20811451
esv2714015 CNV deletion 23290073
esv2760415 CNV gain 21179565
esv3570387 CNV gain 25503493
esv3638041 CNV gain 21293372
esv3638042 CNV gain 21293372
nsv1045194 CNV gain 25217958
nsv1047898 CNV loss 25217958
nsv1048188 CNV gain 25217958
nsv1049647 CNV gain+loss 25217958
nsv1125134 CNV deletion 24896259
nsv435664 CNV deletion 17901297
nsv442391 CNV gain 18776908
nsv457428 CNV gain 19166990
nsv457432 CNV gain 19166990
nsv457436 CNV gain 19166990
nsv471085 CNV gain 18288195
nsv514795 CNV gain 21397061
nsv571543 CNV gain 21841781
nsv833149 CNV loss 17160897

Variation tolerance for FOPNL Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.45; 88.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOPNL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOPNL Gene

Disorders for FOPNL Gene

Relevant External Links for FOPNL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FOPNL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOPNL Gene

Publications for FOPNL Gene

  1. Control of ciliogenesis by FOR20, a novel centrosome and pericentriolar satellite protein. (PMID: 20551181) Sedjai F. … Rosnet O. (J. Cell Sci. 2010) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for FOPNL Gene

Sources for FOPNL Gene

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