FOPNL Gene
protein-coding GIFtS: 46
GCID: GC16M015959
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FGFR1OP N-terminal like(Previous name: chromosome 16 open reading frame 63 )
(Previous symbol: C16orf63)
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Aliases
for FOPNL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FGFR1OP N-Terminal Like1 2 | | DKFZp686N16511 | | C16orf631 2 3 | | FLJ311531 | | FOR201 2 3 | | Chromosome 16 Open Reading Frame 631 | | PHSECRG21 2 3 | | LisH Domain-Containing Protein C16orf632 | | FGFR1OP N-Terminal-Like Protein2 3 | | LisH Domain-Containing Protein FOPNL2 | | FOP-Related Protein Of 20 KDa2 3 | | Pluripotent Embryonic Stem Cell-Related Protein2 |
Export aliases for FOPNL gene to outside databases |
Summaries
for FOPNL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FOPNL_HUMAN, Q96NB1Function: Involved in the biogenesis of cilia
|
Genomic Views
for FOPNL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for FOPNL
Other transcription factors
Search SABiosciences Chromatin IP Primers for FOPNL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOPNL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.11 Ensembl cytogenetic band: 16p13.11 HGNC cytogenetic band: 16p13.11FOPNL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M015959: view genomic region
(about GC identifiers)
Start:
|
15,959,577 bp from pter |
End:
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15,982,482 bp from pter |
Size:
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22,906 bases |
Orientation:
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minus strand |
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Proteins
for FOPNL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FOPNL_HUMAN, Q96NB1 (See
protein sequence)Recommended Name: LisH domain-containing protein FOPNL Size: 174 amino acids; 19778 Da
Subunit: Homooligomer; probably required for localization to centrosomes
Subcellular location: Cell projection, cilium (By similarity). Cytoplasm, cytoskeleton, cilium basal body (Bysimilarity). Cytoplasm, cytoskeleton, centrosome. Cytoplasmic granule. Note=Localizes to pericentriolar satellites,small (70-100 nm) cytoplasmic granules associated with the centrosomeExplore the universe of human proteins at neXtProt for FOPNL: NX_Q96NB1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96NB1
FOPNL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_653201.1
ENSEMBL proteins: ENSP00000255759 ENSP00000460312 ENSP00000458159 ENSP00000461548 ENSP00000459429 ENSP00000460592 ENSP00000459804 ENSP00000461830 ENSP00000458348
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
FOPNL for ontologies About GeneDecksing
FOPNL Antibody Products:
Assay Products for FOPNL: |
Protein
Domains /
Families
for FOPNL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FOPNL for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96NB1ProtoNet protein and cluster: Q96NB1 1 Blocks protein family: IPB006594 Lissencephaly type-1-like homology motif
UniProtKB/Swiss-Prot: FOPNL_HUMAN, Q96NB1Similarity: Belongs to the FGFR1OP familySimilarity: Contains 1 LisH domain |
Function
for FOPNL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FOPNL_HUMAN, Q96NB1Function: Involved in the biogenesis of cilia
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOPNL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOPNL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: FOPNL (NM_144600) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOPNL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOPNL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOPNL |
2 GenomeRNAi human phenotypes for FOPNL:
|
Pathways & Interactions
for FOPNL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOPNL
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for FOPNL (Q96NB13 ENSP000002557594) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
FOPNL for ontologies About GeneDecksing
|
Drugs & Compounds
for FOPNL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FOPNL
Search CenterWatch for drugs/clinical trials and news about FOPNL
|
Transcripts
for FOPNL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FOPNL gene: NM_144600.2 Unigene Cluster for FOPNL: FGFR1OP N-terminal like Hs.514179 [show with all ESTs]Unigene Representative Sequence: AL8324989 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000255759(uc002dec.1 uc002ded.1) ENST00000573968 ENST00000573087
ENST00000573396 ENST00000575744 ENST00000572415 ENST00000575073 ENST00000573429
ENST00000575938
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOPNL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOPNL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FOPNL (NM_144600) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOPNL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOPNL |
Additional cDNA sequence: AK055715.1 AK056798.1 AL832498.1 AY507846.1 BC022321.1 17 DOTS entries: DT.220206 DT.407139 DT.120692409 DT.216317 DT.120692048 DT.97858885 DT.120692368 DT.120692065 DT.120692162 DT.120692416 DT.120692818 DT.120691855 DT.100703389 DT.100035977 DT.91760235 DT.100682426 DT.120692247 24/198 AceView cDNA sequences (see all 198): AA680378 AI619613 AI640264 BU167036 AW029069 CR611801 AI289975 AA737455 AA040230 AI218044 AL710022 AA937723 CR626394 AW027959 BE439944 BM788304 AA281785 F35824 AK056798 BM968446 BX642352 BC022321 BX509566 AW961031
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for FOPNL About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e |
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| SP1: | | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for FOPNL
|
Expression
for FOPNL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FOPNL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAGACTATA
About this image
See FOPNL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FOPNL
SOURCE GeneReport for Unigene cluster: Hs.514179
UniProtKB/Swiss-Prot: FOPNL_HUMAN, Q96NB1Tissue specificity: Widely expressed. Detected in brain, heart, kidney, liver, lung, skeletal muscle, placenta andintestine
SABiosciences Custom PCR Arrays for FOPNL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOPNL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FOPNL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOPNL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOPNL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOPNL |
Orthologs
for FOPNL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FOPNL gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for FOPNL (if available)
TreeFam Gene Tree for FOPNL (if available) |
Paralogs
for FOPNL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FOPNL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FOPNL (15959577 - 15982482 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FOPNL: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOPNL |
|
Disorders
/ Diseases
for FOPNL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FOPNL for disorders About GeneDecksing
3  diseases for FOPNL: About MalaCardsidiopathic generalized epilepsy generalized epilepsy lissencephaly
Export disorders for FOPNL gene to outside databases
|
Publications
for FOPNL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FOPNL gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with FOPNL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Control of ciliogenesis by FOR20, a novel centrosome and pericentriolar satellite protein. (PubMed id 20551181)1, 2 Sedjai F.... Rosnet O. (2010)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Recurrent microdeletions at 15q11.2 and 16p13.11 pred ispose to idiopathic generalized epilepsies. (PubMed id 19843651)1 de Kovel C.G....Sander T. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
|
External Searches for FOPNL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FOPNL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FOPNL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FOPNL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FOPNL | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FOPNL gene:
Search GeneIP for patents involving FOPNL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FOPNL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FOPNL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOPNL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOPNL | | | OriGene Protein Over-expression Lysate for FOPNL | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FOPNL | | OriGene 3'-UTR Clone for FOPNL | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOPNL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOPNL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FOPNL | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FOPNL | | OriGene Custom Protein Services for FOPNL | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FOPNL | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOPNL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOPNL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOPNL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOPNL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOPNL |
| |
 |  |  |  | |
| | | | Search Tocris compounds for FOPNL |
| |  |  |  |  | | | | | | Recombinant Protein for FOPNL |
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 | | | FOPNL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOPNL |
|  |  |  | | | | Search ThermoFisher Antibodies for FOPNL |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOPNL |
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