Aliases for FOLR3 Gene
External Ids for FOLR3 Gene
Previous GeneCards Identifiers for FOLR3 Gene
This gene encodes a member of the folate receptor (FOLR) family of proteins, which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Expression of this gene may be elevated in ovarian and primary peritoneal carcinoma. This gene is present in a gene cluster on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for FOLR3 Gene
FOLR3 (Folate Receptor 3) is a Protein Coding gene. Diseases associated with FOLR3 include Primary Peritoneal Carcinoma. Among its related pathways are Innate Immune System and Antifolate resistance. Gene Ontology (GO) annotations related to this gene include folic acid binding. An important paralog of this gene is FOLR2.
UniProtKB/Swiss-Prot for FOLR3 Gene
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate.