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Aliases for FOLR3 Gene

Aliases for FOLR3 Gene

  • Folate Receptor 3 (Gamma) 2 3
  • FR-Gamma 3 4
  • Folate Receptor Gamma 3
  • Folate Receptor 3 4
  • Gamma-HFR 3
  • FR-G 3

External Ids for FOLR3 Gene

Summaries for FOLR3 Gene

Entrez Gene Summary for FOLR3 Gene

  • This gene encodes a member of the folate receptor (FOLR) family, members of which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This gene includes two polymorphic variants; the shorter one has two base deletion in the CDS, resulting in a truncated polypeptide, compared to the longer one. Both protein products are constitutively secreted in hematopoietic tissues and are potential serum marker for certain hematopoietic malignancies. The longer protein has a 71% and 79% sequence homology with the FOLR1 and FOLR2 proteins, respectively. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOLR3 Gene

FOLR3 (Folate Receptor 3 (Gamma)) is a Protein Coding gene. Among its related pathways are Endocytosis. GO annotations related to this gene include folic acid binding. An important paralog of this gene is FOLR1.

UniProtKB/Swiss-Prot for FOLR3 Gene

  • Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOLR3 Gene

Genomics for FOLR3 Gene

Genomic Location for FOLR3 Gene

Start:
72,114,869 bp from pter
End:
72,139,892 bp from pter
Size:
25,024 bases
Orientation:
Plus strand

Genomic View for FOLR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOLR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOLR3 Gene

Regulatory Elements for FOLR3 Gene

Proteins for FOLR3 Gene

  • Protein details for FOLR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41439-FOLR3_HUMAN
    Recommended name:
    Folate receptor gamma
    Protein Accession:
    P41439
    Secondary Accessions:
    • J3KQ90
    • Q05C14

    Protein attributes for FOLR3 Gene

    Size:
    243 amino acids
    Molecular mass:
    27638 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH30285.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FOLR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOLR3 Gene

Proteomics data for FOLR3 Gene at MOPED

Post-translational modifications for FOLR3 Gene

  • Glycosylation at Asn119, Asn159, and Asn199

Other Protein References for FOLR3 Gene

No data available for DME Specific Peptides for FOLR3 Gene

Domains for FOLR3 Gene

Protein Domains for FOLR3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

FOLR3_HUMAN
Family:
  • Belongs to the folate receptor family.:
    • P41439
genes like me logo Genes that share domains with FOLR3: view

No data available for Gene Families for FOLR3 Gene

Function for FOLR3 Gene

Molecular function for FOLR3 Gene

UniProtKB/Swiss-Prot Function: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate

Gene Ontology (GO) - Molecular Function for FOLR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005542 folic acid binding IEA --
genes like me logo Genes that share ontologies with FOLR3: view

Phenotypes for FOLR3 Gene

GenomeRNAi human phenotypes for FOLR3:
genes like me logo Genes that share phenotypes with FOLR3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FOLR3 Gene

Localization for FOLR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOLR3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOLR3 Gene COMPARTMENTS Subcellular localization image for FOLR3 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for FOLR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane TAS 8110752
GO:0019898 extrinsic component of membrane TAS 8110752
genes like me logo Genes that share ontologies with FOLR3: view

Pathways for FOLR3 Gene

SuperPathways for FOLR3 Gene

Superpath Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with FOLR3: view

Pathways by source for FOLR3 Gene

1 KEGG pathway for FOLR3 Gene

Interacting Proteins for FOLR3 Gene

Gene Ontology (GO) - Biological Process for FOLR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015884 folic acid transport TAS 8110752
genes like me logo Genes that share ontologies with FOLR3: view

Compounds for FOLR3 Gene

(1) HMDB Compounds for FOLR3 Gene

Compound Synonyms Cas Number PubMed IDs
Folic acid
  • Acifolic
59-30-3

(1) Drugbank Compounds for FOLR3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Folic Acid
  • Folate
59-30-3 target binder
genes like me logo Genes that share compounds with FOLR3: view

Transcripts for FOLR3 Gene

Unigene Clusters for FOLR3 Gene

Folate receptor 3 (gamma):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOLR3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for FOLR3 Gene

GeneLoc Exon Structure for
FOLR3
ECgene alternative splicing isoforms for
FOLR3

Expression for FOLR3 Gene

mRNA expression in normal human tissues for FOLR3 Gene

mRNA differential expression in normal tissues according to GTEx for FOLR3 Gene

This gene is overexpressed in Whole Blood (48.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FOLR3 Gene

SOURCE GeneReport for Unigene cluster for FOLR3 Gene Hs.352

mRNA Expression by UniProt/SwissProt for FOLR3 Gene

P41439-FOLR3_HUMAN
Tissue specificity: Spleen, thymus, bone marrow, ovarian carcinoma, and uterine carcinoma
genes like me logo Genes that share expressions with FOLR3: view

Orthologs for FOLR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOLR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOLR3 36
  • 99.32 (n)
  • 98.37 (a)
FOLR3 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 49 (a)
ManyToMany
-- 37
  • 49 (a)
ManyToMany
-- 37
  • 46 (a)
ManyToMany
chicken
(Gallus gallus)
Aves FOLR1 37
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 23 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii FOLR1 37
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
ManyToMany
-- 37
  • 26 (a)
ManyToMany
Species with no ortholog for FOLR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOLR3 Gene

ENSEMBL:
Gene Tree for FOLR3 (if available)
TreeFam:
Gene Tree for FOLR3 (if available)

Paralogs for FOLR3 Gene

Paralogs for FOLR3 Gene

Selected SIMAP similar genes for FOLR3 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for FOLR3 Gene

genes like me logo Genes that share paralogs with FOLR3: view

Variants for FOLR3 Gene

Sequence variations from dbSNP and Humsavar for FOLR3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs471547 -- 72,135,133(+) TTCCC(G/T)AACAG upstream-variant-2KB
rs499716 -- 72,135,636(+) TTTGA(A/G)AAGAA upstream-variant-2KB
rs499717 -- 72,135,638(+) TGAAA(A/G)GAATT upstream-variant-2KB
rs508088 -- 72,139,612(+) GGGGC(C/T)CTCTG reference, frameshift-variant
rs508114 -- 72,139,619(+) TCTGC(A/C)GCACC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FOLR3 Gene

Variant ID Type Subtype PubMed ID
esv2744761 CNV Deletion 23290073
esv2671723 CNV Deletion 23128226

Relevant External Links for FOLR3 Gene

HapMap Linkage Disequilibrium report
FOLR3

Disorders for FOLR3 Gene

Relevant External Links for FOLR3

Genetic Association Database (GAD)
FOLR3
Human Genome Epidemiology (HuGE) Navigator
FOLR3
genes like me logo Genes that share disorders with FOLR3: view

No data available for UniProtKB/Swiss-Prot for FOLR3 Gene

Publications for FOLR3 Gene

  1. Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity. (PMID: 8110752) Shen F. … Ratnam M. (Biochemistry 1994) 2 3 4 25
  2. Folate receptor type gamma is primarily a secretory protein due to lack of an efficient signal for glycosylphosphatidylinositol modification: protein characterization and cell type specificity. (PMID: 7727426) Shen F. … Ratnam M. (Biochemistry 1995) 3 4 25
  3. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman R.T. … Brenner S.E. (Genome Biol. 2004) 3 4
  4. Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study. (PMID: 19048631) Boyles A.L. … Lie R.T. (Genet. Epidemiol. 2009) 3 49
  5. An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PMID: 19161160) Franke B. … Blom H.J. (Birth Defects Res. Part A Clin. Mol. Teratol. 2009) 3 49

Products for FOLR3 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate FOLR3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for FOLR3
    • Block miRNA regulation of FOLR3 using miScript Target Protectors

    Sources for FOLR3 Gene

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