Aliases for FOLR3 Gene
External Ids for FOLR3 Gene
Previous GeneCards Identifiers for FOLR3 Gene
This gene encodes a member of the folate receptor (FOLR) family, members of which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This gene includes two polymorphic variants; the shorter one has two base deletion in the CDS, resulting in a truncated polypeptide, compared to the longer one. Both protein products are constitutively secreted in hematopoietic tissues and are potential serum marker for certain hematopoietic malignancies. The longer protein has a 71% and 79% sequence homology with the FOLR1 and FOLR2 proteins, respectively. [provided by RefSeq, Jul 2008]
GeneCards Summary for FOLR3 Gene
FOLR3 (Folate Receptor 3 (Gamma)) is a Protein Coding gene. Among its related pathways are Endocytosis. GO annotations related to this gene include folic acid binding. An important paralog of this gene is FOLR1.
UniProtKB/Swiss-Prot for FOLR3 Gene
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate