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FOLR3 Gene

protein-coding   GIFtS: 53
GCID: GC11P071825

Folate Receptor 3 (Gamma)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Folate Receptor 3 (Gamma)1 2
FR-gamma2 3
FR-G2
Folate Receptor Gamma2
gamma-hFR2
Folate Receptor 33

External Ids:    HGNC: 37951   Entrez Gene: 23522   Ensembl: ENSG000001102037   OMIM: 6024695   UniProtKB: P414393   

Export aliases for FOLR3 gene to outside databases

Previous GC identifers: GC11P074178 GC11P073386 GC11P072048 GC11P071573 GC11P071524 GC11P071846 GC11P068140


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FOLR3 Gene:
This gene encodes a member of the folate receptor (FOLR) family, members of which have a high affinity for folic
acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the
interior of cells. This gene includes two polymorphic variants; the shorter one has two base deletion in the CDS,
resulting in a truncated polypeptide, compared to the longer one. Both protein products are constitutively
secreted in hematopoietic tissues and are potential serum marker for certain hematopoietic malignancies. The
longer protein has a 71% and 79% sequence homology with the FOLR1 and FOLR2 proteins, respectively. (provided by
RefSeq, Jul 2008)

GeneCards Summary for FOLR3 Gene:
FOLR3 (folate receptor 3 (gamma)) is a protein-coding gene. Diseases associated with FOLR3 include spina bifida, and malignant mesothelioma. GO annotations related to this gene include folic acid binding. An important paralog of this gene is FOLR4.

UniProtKB/Swiss-Prot: FOLR3_HUMAN, P41439
Function: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to
the interior of cells. Isoform Short does not bind folate




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FOLR3 gene promoter:
         HFH-3   FOXD3   YY1   NF-AT   FOXI1   PPAR-alpha   NF-AT4   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOLR3 promoter sequence
   Search Chromatin IP Primers for FOLR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOLR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.4

FOLR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOLR3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P071825:  view genomic region     (about GC identifiers)

Start:
71,825,915 bp from pter      End:
71,850,936 bp from pter
Size:
25,022 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FOLR3_HUMAN, P41439 (See protein sequence)
Recommended Name: Folate receptor gamma precursor  
Size: 243 amino acids; 27638 Da
Alternative splicing: 2 isoforms:  P41439-1   P41439-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for FOLR3: NX_P41439

Explore proteomics data for FOLR3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn119, Asn159, Asn199

  • See FOLR3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000795.2  
    ENSEMBL proteins: 
     ENSP00000443558   ENSP00000390338   ENSP00000325032   ENSP00000446279   ENSP00000399235  
     ENSP00000411161  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR018143 Folate_rcpt-like
     IPR004269 Folate_rcpt

    Graphical View of Domain Structure for InterPro Entry P41439

    ProtoNet protein and cluster: P41439

    1 Blocks protein domain: IPB004269 Folate receptor

    UniProtKB/Swiss-Prot: FOLR3_HUMAN, P41439
    Similarity: Belongs to the folate receptor family


    FOLR3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOLR3_HUMAN, P41439
    Function: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to
    the interior of cells. Isoform Short does not bind folate

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005542folic acid binding IEA--
         
    FOLR3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FOLR3:
     Wnt reporter downregulated 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FOLR3_HUMAN, P41439: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0016020membrane TAS8110752
    GO:0019898extrinsic component of membrane TAS8110752

    FOLR3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FOLR3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Endocytosis
    Endocytosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for FOLR3):
        Endocytosis


    FOLR3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FOLR3
    Interactions:

        Search GeneGlobe Interaction Network for FOLR3

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015884folic acid transport TAS8110752

    FOLR3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FOLR3

    1 HMDB Compound for FOLR3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Folic acidAcifolic (see all 37)59-30-3--

    1 DrugBank Compound for FOLR3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Folic AcidFolate (see all 9)59-30-3targetbinder8061055 17139284 7727426 11752352 8110752 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FOLR3 gene: 
    NM_000804.2  

    Unigene Cluster for FOLR3:

    Folate receptor 3 (gamma)
    Hs.352  [show with all ESTs]
    Unigene Representative Sequence: NM_000804
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000542161 ENST00000445078 ENST00000325101 ENST00000546166 ENST00000545379
    ENST00000456237(uc001ory.1) ENST00000442948(uc001orx.1)
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      QuantiFast Probe-based Assays in human, mouse, rat FOLR3

    Additional mRNA sequence: 

    BC030285.1 BC126398.1 U08470.1 U08471.1 Z32564.1 Z32633.1 

    4 DOTS entries:

    DT.411266  DT.75102105  DT.95255937  DT.99944524 

    Selected AceView cDNA sequences (see all 40):

    AI693673 CA431459 AI003764 AI082081 BU629900 BE501541 BE048463 CA430295 
    AI521145 AI628141 AW194724 CA431894 CA310136 AW772247 AI582155 AI861852 
    AW302181 AI185699 CD368314 Z32564 BC030285 AW615302 CA443646 BI836723 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FOLR3    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
    SP1:                                          
    SP2:              -                           


    ECgene alternative splicing isoforms for FOLR3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FOLR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGCTGGGG
    FOLR3 Expression
    About this image

    FOLR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FOLR3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.352

    UniProtKB/Swiss-Prot: FOLR3_HUMAN, P41439
    Tissue specificity: Spleen, thymus, bone marrow, ovarian carcinoma, and uterine carcinoma

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FOLR3 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    49(a)
    49(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    4(348055028-348064265)
    4(348008774-348014864)
    chicken
    (Gallus gallus)
    Aves FOLR16
    Gallus gallus folate receptor 1 (adult) (FOLR1), m...
    42(a)
    1 → many
    1(193685559-193688956) ENSGALG00000017343
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    23(a)
    1 → many
    AAWZ02038598(1643-1834)
    zebrafish
    (Danio rerio)
    Actinopterygii FOLR16
    folate receptor 1 (adult)
    38(a)
    1 → many
    15(46932044-46938985) ENSDARG00000075659


    ENSEMBL Gene Tree for FOLR3 (if available)
    TreeFam Gene Tree for FOLR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FOLR3 gene
    FOLR42  FOLR12  FOLR22  
    3 SIMAP similar genes for FOLR3 using alignment to 6 protein entries:     FOLR3_HUMAN (see all proteins):
    FOLR2    FOLR1    FOLR4

    FOLR3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FOLR3
    PGOHUM00000242790


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FOLR3 (see all 215)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1892984551,2
    --71708763(+) ACCCTC/TCCAAA 1 -- us2k10--------
    rs1177748401,2
    C,F--71708788(+) AGCTCG/CCACCA 1 -- us2k11Minor allele frequency- C:0.04NA 120
    rs1473171481,2
    C--71708842(+) TTCCTA/GTGTTG 1 -- us2k10--------
    rs772064441,2
    F--71708905(+) CAAAAC/TGCTGG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1392556551,2
    C--71708906(+) AAAACG/TCTGGG 1 -- us2k10--------
    rs773138971,2
    C,F--71708918(+) TTACAG/CGTGTA 1 -- us2k12Minor allele frequency- C:0.03WA NA 238
    rs79250551,2
    C,F,H--71709039(+) GTAATA/GCTCAA 1 -- us2k1 tfbs39Minor allele frequency- G:0.10NS EA WA CSA NA 660
    rs1414977601,2
    --71709050(+) GTGTGC/TAACTG 1 -- us2k10--------
    rs1807953781,2
    --71709074(+) TTCATA/GAGGTT 1 -- us2k10--------
    rs800230291,2
    C,F--71709107(+) AAATTT/CATAGT 1 -- us2k12Minor allele frequency- C:0.11WA 120

    HapMap Linkage Disequilibrium report for FOLR3 (71825915 - 71850936 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FOLR3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744761CNV Deletion23290073
    esv2671723CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602469    OMIM disorders: --

    2 diseases for FOLR3:    About MalaCards
    spina bifida    malignant mesothelioma


    FOLR3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FOLR3
    Human Genome Epidemiology (HuGE) Navigator: FOLR3 (4 documents)

    Export disorders for FOLR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FOLR3 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with FOLR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity. (PubMed id 8110752)1, 2, 3, 7 Shen F.... Ratnam M. (Biochemistry 1994)
    2. Folate receptor type gamma is primarily a secretory protein due to lack of an efficient signal for glycosylphosphatidylinositol modification: protein characterization and cell type specificity. (PubMed id 7727426)1, 2, 7 Shen F.... Ratnam M. (Biochemistry 1995)
    3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    4. Association of folate receptor (FOLR1, FOLR2, FOLR3) and reduced folate carrier (SLC19A1) genes with meningomyelocele. (PubMed id 20683905)1, 4 O'Byrne M.R....Northrup H. (Birth Defects Res. Part A Clin. Mol. Teratol. 2010)
    5. Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study. (PubMed id 19048631)1, 4 Boyles A.L....Lie R.T. (Genet. Epidemiol. 2009)
    6. An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PubMed id 19161160)1, 4 Franke B....Blom H.J. (Birth Defects Res. Part A Clin. Mol. Teratol. 2009)
    7. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    8. Effects of partner proteins on BCA2 RING ligase activity. (PubMed id 22315970)1 Bacopulos S....Seth A.K. (BMC Cancer 2012)
    9. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)
    10. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2352 HGNC: 3795 AceView: FOLR3 Ensembl:ENSG00000110203 euGenes: HUgn2352
    ECgene: FOLR3 Kegg: 2352 H-InvDB: FOLR3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FOLR3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FOLR3 gene:
    Search GeneIP for patents involving FOLR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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