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Aliases for FOLR3 Gene

Aliases for FOLR3 Gene

  • Folate Receptor 3 (Gamma) 2 3 5
  • FR-Gamma 3 4
  • Folate Receptor 3 4
  • Gamma-HFR 3
  • FR-G 3

External Ids for FOLR3 Gene

Previous GeneCards Identifiers for FOLR3 Gene

  • GC11P074178
  • GC11P073386
  • GC11P072048
  • GC11P071573
  • GC11P071524
  • GC11P071846
  • GC11P068140
  • GC11P071825

Summaries for FOLR3 Gene

Entrez Gene Summary for FOLR3 Gene

  • This gene encodes a member of the folate receptor (FOLR) family of proteins, which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Expression of this gene may be elevated in ovarian and primary peritoneal carcinoma. This gene is present in a gene cluster on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for FOLR3 Gene

FOLR3 (Folate Receptor 3 (Gamma)) is a Protein Coding gene. Diseases associated with FOLR3 include Primary Peritoneal Carcinoma. Among its related pathways are Endocytosis. GO annotations related to this gene include folic acid binding. An important paralog of this gene is FOLR1.

UniProtKB/Swiss-Prot for FOLR3 Gene

  • Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOLR3 Gene

Genomics for FOLR3 Gene

Regulatory Elements for FOLR3 Gene

Enhancers for FOLR3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FOLR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOLR3 Gene

Chromosome:
11
Start:
72,114,869 bp from pter
End:
72,139,892 bp from pter
Size:
25,024 bases
Orientation:
Plus strand

Genomic View for FOLR3 Gene

Genes around FOLR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOLR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOLR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOLR3 Gene

Proteins for FOLR3 Gene

  • Protein details for FOLR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41439-FOLR3_HUMAN
    Recommended name:
    Folate receptor gamma
    Protein Accession:
    P41439
    Secondary Accessions:
    • J3KQ90
    • Q05C14

    Protein attributes for FOLR3 Gene

    Size:
    243 amino acids
    Molecular mass:
    27638 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH30285.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FOLR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOLR3 Gene

Proteomics data for FOLR3 Gene at MOPED

Post-translational modifications for FOLR3 Gene

  • Glycosylation at Asn 119, Asn 159, and Asn 199
  • Modification sites at PhosphoSitePlus

Other Protein References for FOLR3 Gene

Antibody Products

  • Abcam antibodies for FOLR3

No data available for DME Specific Peptides for FOLR3 Gene

Domains & Families for FOLR3 Gene

Protein Domains for FOLR3 Gene

Suggested Antigen Peptide Sequences for FOLR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41439

UniProtKB/Swiss-Prot:

FOLR3_HUMAN :
  • Belongs to the folate receptor family.
Family:
  • Belongs to the folate receptor family.
genes like me logo Genes that share domains with FOLR3: view

No data available for Gene Families for FOLR3 Gene

Function for FOLR3 Gene

Molecular function for FOLR3 Gene

UniProtKB/Swiss-Prot Function:
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate.
genes like me logo Genes that share phenotypes with FOLR3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FOLR3 Gene

Localization for FOLR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOLR3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOLR3 Gene COMPARTMENTS Subcellular localization image for FOLR3 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for FOLR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 8110752
GO:0019898 extrinsic component of membrane TAS 8110752
genes like me logo Genes that share ontologies with FOLR3: view

Pathways & Interactions for FOLR3 Gene

SuperPathways for FOLR3 Gene

Superpath Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with FOLR3: view

Pathways by source for FOLR3 Gene

1 KEGG pathway for FOLR3 Gene

Interacting Proteins for FOLR3 Gene

Gene Ontology (GO) - Biological Process for FOLR3 Gene

None

No data available for SIGNOR curated interactions for FOLR3 Gene

Drugs & Compounds for FOLR3 Gene

(3) Drugs for FOLR3 Gene - From: DrugBank, PharmGKB, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Folic Acid Approved Nutra Target, binder 4079
Pemetrexed Approved, Investigational Pharma TS, DHFR,GARFT and AICARFT inhibitor, DHFR and Thymidylate synthase inhibitor, Anti-Folates 587
EC145 Investigational Pharma Target 0
genes like me logo Genes that share compounds with FOLR3: view

Transcripts for FOLR3 Gene

Unigene Clusters for FOLR3 Gene

Folate receptor 3 (gamma):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOLR3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for FOLR3 Gene

GeneLoc Exon Structure for
FOLR3
ECgene alternative splicing isoforms for
FOLR3

Expression for FOLR3 Gene

mRNA expression in normal human tissues for FOLR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOLR3 Gene

This gene is overexpressed in Whole Blood (x48.5).

Protein differential expression in normal tissues from HIPED for FOLR3 Gene

This gene is overexpressed in Neutrophil (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FOLR3 Gene



SOURCE GeneReport for Unigene cluster for FOLR3 Gene Hs.352

mRNA Expression by UniProt/SwissProt for FOLR3 Gene

P41439-FOLR3_HUMAN
Tissue specificity: Spleen, thymus, bone marrow, ovarian carcinoma, and uterine carcinoma.
genes like me logo Genes that share expression patterns with FOLR3: view

Protein tissue co-expression partners for FOLR3 Gene

- Elite partner

Primer Products

Orthologs for FOLR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOLR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOLR3 35
  • 99.32 (n)
  • 98.37 (a)
FOLR3 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 49 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
chicken
(Gallus gallus)
Aves FOLR1 36
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii FOLR1 36
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
Species with no ortholog for FOLR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOLR3 Gene

ENSEMBL:
Gene Tree for FOLR3 (if available)
TreeFam:
Gene Tree for FOLR3 (if available)

Paralogs for FOLR3 Gene

Paralogs for FOLR3 Gene

(3) SIMAP similar genes for FOLR3 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for FOLR3 Gene

genes like me logo Genes that share paralogs with FOLR3: view

Variants for FOLR3 Gene

Sequence variations from dbSNP and Humsavar for FOLR3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs532360 -- 72,137,172(+) GAAAT(G/T)TTATG intron-variant, upstream-variant-2KB
rs533207 -- 72,137,240(+) AAAAA(A/C)CTCCA intron-variant, upstream-variant-2KB
rs605241 -- 72,135,728(-) CCAGG(C/T)TCTGA upstream-variant-2KB, utr-variant-5-prime
rs606136 -- 72,135,526(-) TGGCA(A/G)CTGAG upstream-variant-2KB
rs637609 -- 72,139,675(-) GAGTG(A/G)CTCCA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for FOLR3 Gene

Variant ID Type Subtype PubMed ID
esv2744761 CNV Deletion 23290073
esv2671723 CNV Deletion 23128226

Variation tolerance for FOLR3 Gene

Gene Damage Index Score: 6.27; 76.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FOLR3 Gene

Disorders for FOLR3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FOLR3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
primary peritoneal carcinoma
  • serous surface papillary carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search FOLR3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FOLR3

Genetic Association Database (GAD)
FOLR3
Human Genome Epidemiology (HuGE) Navigator
FOLR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOLR3
genes like me logo Genes that share disorders with FOLR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOLR3 Gene

Publications for FOLR3 Gene

  1. Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity. (PMID: 8110752) Shen F. … Ratnam M. (Biochemistry 1994) 2 3 4 25 26 67
  2. Folate receptor type gamma is primarily a secretory protein due to lack of an efficient signal for glycosylphosphatidylinositol modification: protein characterization and cell type specificity. (PMID: 7727426) Shen F. … Ratnam M. (Biochemistry 1995) 3 25 26
  3. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  4. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  5. TTD: Therapeutic Target Database. (PMID: 11752352) Chen X. … Chen Y.Z. (Nucleic Acids Res. 2002) 25 26

Products for FOLR3 Gene

Sources for FOLR3 Gene

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