FOLR3 Gene
protein-coding GIFtS : 53
GCID: GC11 P071825
folate receptor 3 (gamma)
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Aliasesfor FOLR3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Folate Receptor 3 (Gamma) 1 2 FR-G1 2 FR-Gamma1 Folate Receptor Gamma2 Gamma-HFR1 Folate Receptor 33
Export aliases for FOLR3 gene to outside databases Previous GC identifers: GC11P074178 GC11P073386 GC11P072048 GC11P071573 GC11P071524 GC11P071846 GC11P068140
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Summariesfor FOLR3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for FOLR3 : This gene encodes a member of the folate receptor (FOLR) family, members of which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This gene includes two polymorphic variants; the shorter one has two base deletion in the CDS, resulting in a truncated polypeptide, compared to the longer one. Both protein products are constitutively secreted in hematopoietic tissues and are potential serum marker for certain hematopoietic malignancies. The longer protein has a 71% and 79% sequence homology with the FOLR1 and FOLR2 proteins, respectively. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: FOLR3_HUMAN, P41439 Function : Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to theinterior of cells. Isoform Short does not bind folate
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Genomic Viewsfor FOLR3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_167190.1 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FOLR3 gene promoter: HFH-3 FOXD3 YY1 NF-AT FOXI1 PPAR-alpha NF-AT4 NF-AT2 NF-AT3 NF-AT1 Other transcription factors Search SABiosciences Chromatin IP Primers for FOLR3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOLR3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13.4 FOLR3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P071825: view genomic region
(about GC identifiers )
Start:
71,825,915 bp from pter
End:
71,850,936 bp from pter
Size:
25,022 bases
Orientation:
plus strand
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Proteinsfor FOLR3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: FOLR3_HUMAN, P41439 (See
protein sequence )Recommended Name: Folate receptor gamma precursor Size : 243 amino acids; 27638 Da
Subcellular location : SecretedAlternative splicing : 2 isoforms : P41439-1 P41439-2 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)Explore the universe of human proteins at neXtProt for FOLR3: NX_P41439 Post-translational modifications:
Eight disulfide bonds are present (Probable)1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P41439 FOLR3 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_000795.2 ENSEMBL proteins: ENSP00000443558 ENSP00000390338 ENSP00000325032 ENSP00000446279 ENSP00000399235 ENSP00000411161 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
FOLR3 for ontologies About GeneDecksing FOLR3 Antibody Products: Assay Products for FOLR3:
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Protein
Domains / Familiesfor FOLR3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
FOLR3 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P41439 ProtoNet protein and cluster: P41439
1 Blocks protein family : IPB004269 Folate receptor UniProtKB/Swiss-Prot: FOLR3_HUMAN, P41439 Similarity : Belongs to the folate receptor family
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Functionfor FOLR3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: FOLR3_HUMAN, P41439 Function : Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to theinterior of cells. Isoform Short does not bind folate
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FOLR3 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FOLR3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FOLR3 (NM_000804 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOLR3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FOLR3
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0004872 receptor activity
-- -- GO:0005542 folic acid binding
IEA --
FOLR3 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for FOLR3 :
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Pathways & Interactionsfor FOLR3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Endocytosis
Pathway sources See GeneCards unified pathways Show all pathways 1
Kegg Pathway (Kegg details for FOLR3) :
FOLR3 for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOLR3 Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
FOLR3 for ontologies About GeneDecksing
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Drugs & Compoundsfor FOLR3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for FOLR3 1 HMDB Compound for FOLR3 About this table 1 DrugBank Compound for FOLR3 About this table Search CenterWatch for drugs/clinical trials and news about FOLR3
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Transcriptsfor FOLR3 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for FOLR3 gene: NM_000804.2 Unigene Cluster for FOLR3:
Folate receptor 3 (gamma) Hs.352 [show with all ESTs ] Unigene Representative Sequence: NM_000804 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000542161 ENST00000445078 ENST00000325101 ENST00000546166 ENST00000545379 ENST00000456237 (uc001ory.1 ) ENST00000442948 (uc001orx.1 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FOLR3 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FOLR3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FOLR3 (NM_000804 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOLR3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FOLR3
Additional cDNA sequence: BC030285.1 BC126398.1 U08470.1 U08471.1 Z32564.1 Z32633.1
4 DOTS entries : DT.411266 DT.75102105
DT.95255937 DT.99944524 24/40 AceView cDNA sequences (see all 40 ):
CA310136 AW772247 AI861852 AI003764 AI693673 CA430295 AI582155 BU629900 AI082081 AI521145 CA431894 BE501541 AI628141 AW194724 BE048463 CA431459 CA443646 Z32633 AI478343 BX102950 AI185699 U08471 BF838933 Z32564 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for FOLR3 About this scheme ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b SP1 :               SP2 :     -          
ECgene alternative splicing isoforms for FOLR3
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Expression for FOLR3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section FOLR3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AATGCTGGGG
About this image FOLR3 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ progenitor SK17 (Embryonic Progenitor Cell)Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See FOLR3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FOLR3 SOURCE GeneReport for Unigene cluster: Hs.352 UniProtKB/Swiss-Prot: FOLR3_HUMAN, P41439 Tissue specificity : Spleen, thymus, bone marrow, ovarian carcinoma, and uterine carcinoma SABiosciences Custom PCR Arrays for FOLR3 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FOLR3Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat FOLR3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FOLR3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FOLR3
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Orthologsfor FOLR3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for FOLR3 gene from 3/9 species (see all 9 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
FOLR16
folate receptor 1 (adult)
43(a)
1 → many
1(199402554-199405905)
lizard (Anolis carolinensis)
Reptilia
--
--
25(a)
1 → many
AAWZ02038598(1643-1834)
zebrafish (Danio rerio)
Actinopterygii
zgc:1655026
zgc:165502
37(a)
1 → many
15(46932044-46938985)
ENSEMBL Gene Tree for FOLR3 (if available)TreeFam Gene Tree for FOLR3 (if available)
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Paralogsfor FOLR3 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for FOLR3 gene FOLR4 2 FOLR1 2 FOLR2 2 3 SIMAP similar genes for FOLR3 using alignment to 6 protein entries: FOLR3_HUMAN (see all proteins ):FOLR2 FOLR1 FOLR4
FOLR3 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for FOLR3 PGOHUM00000242790
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Genomic Variantsfor FOLR3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for FOLR3 (71825915 - 71850936 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for FOLR3: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FOLR3
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Disorders
/ Diseasesfor FOLR3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
FOLR3 for disorders About GeneDecksing
OMIM gene information: 602469
OMIM disorders : --4 diseases for FOLR3 : About MalaCards spina bifida ovarian carcinoma breast carcinoma carcinoma Human Genome Epidemiology (HuGE) Navigator: FOLR3 (4 documents) Export disorders for FOLR3 gene to outside databases
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Publicationsfor FOLR3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for FOLR3 gene, integrated from 9 sources (see all 15 ): (articles sorted by number of sources associating them with FOLR3) Utopia : connect your pdf to the dynamic world of online information
Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity. (PubMed id 8110752) 1 , 2 , 3, 7 Shen F.... Ratnam M. (1994) Folate receptor type gamma is primarily a secretory protein due to lack of an efficient signal for glycosylphosphatidylinositol modification: protein characterization and cell type specificity. (PubMed id 7727426) 1 , 2 , 7 Shen F.... Ratnam M. (1995) An unappreciated role for RNA surveillance. (PubMed id 14759258) 1 , 2 Hillman R.T.... Brenner S.E. (2004) Effects of partner proteins on BCA2 RING ligase activi ty. (PubMed id 22315970) 1 Bacopulos S....Seth A.K. (2012) Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891) 1 Jugessur A....Murray J.C. (2010) Association of folate receptor (FOLR1, FOLR2, FOLR3) and reduced folate carrier (SLC19A1) genes with meningomyelocele. (PubMed id 20683905) 1 O'Byrne M.R....Northrup H. (2010) Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study. (PubMed id 19048631) 1 Boyles A.L....Lie R.T. (2009) An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PubMed id 19161160) 1 Franke B....Blom H.J. (2009) Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423) 7 Imming P....Meyer A. (2006) How many drug targets are there? (PubMed id 17139284) 7 Overington J.P....Hopkins A.L. (2006)
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External Searches for FOLR3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FOLR3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FOLR3 gene
(According to HUGE )
About This Section --
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Specialized Databases showing FOLR3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for FOLR3 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for FOLR3 gene: Search GeneIP for patents involving FOLR3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FOLR3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for FOLR3 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for FOLR3 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FOLR3 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for FOLR3 OriGene 3'-UTR Clone for FOLR3 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FOLR3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FOLR3 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for FOLR3 OriGene Custom Protein Services for FOLR3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FOLR3 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FOLR3 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOLR3 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat FOLR3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FOLR3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FOLR3
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FOLR3 Proteins, Antibodies, CLIAs, and ELISAs
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FOLR3
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