Aliases for FOLR2 Gene
External Ids for FOLR2 Gene
Previous GeneCards Identifiers for FOLR2 Gene
The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for FOLR2 Gene
FOLR2 (Folate Receptor 2 (Fetal)) is a Protein Coding gene. Diseases associated with FOLR2 include thiamine metabolism dysfunction syndrome 2 and neural tube defects. Among its related pathways are Endocytosis. GO annotations related to this gene include folic acid binding and folic acid transporter activity. An important paralog of this gene is FOLR1.
UniProtKB/Swiss-Prot for FOLR2 Gene
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.