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Aliases for FOLR2 Gene

Aliases for FOLR2 Gene

  • Folate Receptor Beta 2 3 5
  • Folate Receptor, Fetal/Placental 3 4
  • Placental Folate-Binding Protein 3 4
  • Folate Receptor 2 (Fetal) 2 3
  • FR-BETA 3 4
  • FBP 3 4
  • Folate-Binding Protein, Fetal/Placental 3
  • Folate Receptor 2 4
  • BETA-HFR 3
  • FBP/PL-1 3
  • FR-P3 3

External Ids for FOLR2 Gene

Previous GeneCards Identifiers for FOLR2 Gene

  • GC11U990040
  • GC11P073467
  • GC11P072150
  • GC11P071654
  • GC11P071605
  • GC11P071927
  • GC11P068220

Summaries for FOLR2 Gene

Entrez Gene Summary for FOLR2 Gene

  • The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOLR2 Gene

FOLR2 (Folate Receptor Beta) is a Protein Coding gene. Diseases associated with FOLR2 include Neural Tube Defects and Thiamine Metabolism Dysfunction Syndrome 2. Among its related pathways are Post-translational modification- synthesis of GPI-anchored proteins and Folate Metabolism. GO annotations related to this gene include folic acid binding and folic acid transporter activity. An important paralog of this gene is FOLR3.

UniProtKB/Swiss-Prot for FOLR2 Gene

  • Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.

Gene Wiki entry for FOLR2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOLR2 Gene

Genomics for FOLR2 Gene

Regulatory Elements for FOLR2 Gene

Enhancers for FOLR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G072217 1.4 Ensembl ENCODE 0.7 +1.3 1300 1.0 HDGF FOXA2 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 LOC100128494 ZNF705E LOC100133315 FOLR3 FOLR2 GC11P072220
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FOLR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FOLR2 Gene

Chromosome:
11
Start:
72,216,601 bp from pter
End:
72,221,950 bp from pter
Size:
5,350 bases
Orientation:
Plus strand

Genomic View for FOLR2 Gene

Genes around FOLR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOLR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOLR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOLR2 Gene

Proteins for FOLR2 Gene

  • Protein details for FOLR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14207-FOLR2_HUMAN
    Recommended name:
    Folate receptor beta
    Protein Accession:
    P14207
    Secondary Accessions:
    • Q05CA5
    • Q6GTE8

    Protein attributes for FOLR2 Gene

    Size:
    255 amino acids
    Molecular mass:
    29280 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FOLR2 Gene

neXtProt entry for FOLR2 Gene

Post-translational modifications for FOLR2 Gene

No data available for DME Specific Peptides for FOLR2 Gene

Domains & Families for FOLR2 Gene

Protein Domains for FOLR2 Gene

Suggested Antigen Peptide Sequences for FOLR2 Gene

Graphical View of Domain Structure for InterPro Entry

P14207

UniProtKB/Swiss-Prot:

FOLR2_HUMAN :
  • Belongs to the folate receptor family.
Family:
  • Belongs to the folate receptor family.
genes like me logo Genes that share domains with FOLR2: view

No data available for Gene Families for FOLR2 Gene

Function for FOLR2 Gene

Molecular function for FOLR2 Gene

GENATLAS Biochemistry:
folate receptor 2,fetal
UniProtKB/Swiss-Prot Function:
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
UniProtKB/Swiss-Prot Induction:
Up-regulated by retinoic acid.

Gene Ontology (GO) - Molecular Function for FOLR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005542 folic acid binding IDA 4066659
GO:0008144 drug binding IPI 19116913
GO:0008517 folic acid transporter activity IDA,IEA 4066659
GO:0051870 methotrexate binding IDA 19116913
GO:0061714 folic acid receptor activity IC 19116913
genes like me logo Genes that share ontologies with FOLR2: view
genes like me logo Genes that share phenotypes with FOLR2: view

Animal Models for FOLR2 Gene

MGI Knock Outs for FOLR2:

Animal Model Products

CRISPR Products

miRNA for FOLR2 Gene

miRTarBase miRNAs that target FOLR2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOLR2 Gene

Localization for FOLR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOLR2 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOLR2 gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for FOLR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IDA 25015955
GO:0016020 membrane TAS 2605182
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with FOLR2: view

Pathways & Interactions for FOLR2 Gene

genes like me logo Genes that share pathways with FOLR2: view

Pathways by source for FOLR2 Gene

Interacting Proteins for FOLR2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000298223%0d%0a9606.ENSP00000308137%0d%0a9606.ENSP00000416935%0d%0a9606.ENSP00000327786%0d%0a
Selected Interacting proteins: P14207-FOLR2_HUMAN ENSP00000298223 for FOLR2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for FOLR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 NOT monocyte chemotaxis IDA 25015955
GO:0006501 C-terminal protein lipidation TAS --
GO:0006810 transport IEA --
GO:0006898 receptor-mediated endocytosis IC 19116913
GO:0006954 inflammatory response NAS 25015955
genes like me logo Genes that share ontologies with FOLR2: view

No data available for SIGNOR curated interactions for FOLR2 Gene

Drugs & Compounds for FOLR2 Gene

(5) Drugs for FOLR2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Folic Acid Approved, Vet_approved Nutra Target, binder 4392
EC145 Investigational Pharma Target 0

(3) Additional Compounds for FOLR2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FOLR2: view

Transcripts for FOLR2 Gene

Unigene Clusters for FOLR2 Gene

Folate receptor 2 (fetal):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOLR2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - -
SP2: -
SP3: -
SP4: - - -
SP5: - -
SP6:
SP7: - -
SP8: - -

Relevant External Links for FOLR2 Gene

GeneLoc Exon Structure for
FOLR2
ECgene alternative splicing isoforms for
FOLR2

Expression for FOLR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOLR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOLR2 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x5.7) and Adipose - Subcutaneous (x4.0).

Protein differential expression in normal tissues from HIPED for FOLR2 Gene

This gene is overexpressed in Oral epithelium (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FOLR2 Gene



Protein tissue co-expression partners for FOLR2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FOLR2 Gene:

FOLR2

SOURCE GeneReport for Unigene cluster for FOLR2 Gene:

Hs.433159

mRNA Expression by UniProt/SwissProt for FOLR2 Gene:

P14207-FOLR2_HUMAN
Tissue specificity: Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues.

Evidence on tissue expression from TISSUES for FOLR2 Gene

  • Nervous system(4.2)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with FOLR2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FOLR2 Gene

Orthologs for FOLR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOLR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOLR2 34 35
  • 98.95 (n)
dog
(Canis familiaris)
Mammalia FOLR2 34 35
  • 84.85 (n)
cow
(Bos Taurus)
Mammalia FOLR2 34 35
  • 83.55 (n)
rat
(Rattus norvegicus)
Mammalia Folr2 34
  • 81.71 (n)
mouse
(Mus musculus)
Mammalia Folr2 34 16 35
  • 80.74 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 61 (a)
ManyToMany
-- 35
  • 60 (a)
ManyToMany
-- 35
  • 59 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 22 (a)
ManyToMany
chicken
(Gallus gallus)
Aves FOLR1 35
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 73 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii FOLR1 35
  • 55 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
Species where no ortholog for FOLR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOLR2 Gene

ENSEMBL:
Gene Tree for FOLR2 (if available)
TreeFam:
Gene Tree for FOLR2 (if available)

Paralogs for FOLR2 Gene

Paralogs for FOLR2 Gene

genes like me logo Genes that share paralogs with FOLR2: view

Variants for FOLR2 Gene

Sequence variations from dbSNP and Humsavar for FOLR2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_036408 A breast cancer sample
rs1000342657 -- 72,216,359(+) AAGCC(G/T)ACTCA upstream-variant-2KB
rs1000723079 -- 72,214,984(+) AATAC(C/T)ACAAC upstream-variant-2KB
rs1000842218 -- 72,221,125(+) GATGG(C/T)TGCCA intron-variant
rs1001131748 -- 72,216,522(+) CCACC(A/C)GACCT upstream-variant-2KB

Variation tolerance for FOLR2 Gene

Residual Variation Intolerance Score: 82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOLR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOLR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FOLR2 Gene

Disorders for FOLR2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FOLR2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neural tube defects
  • spina bifida
thiamine metabolism dysfunction syndrome 2
  • biotin-responsive basal ganglia disease
rheumatoid arthritis
  • rheumatoid arthritis, progression of
- elite association - COSMIC cancer census association via MalaCards
Search FOLR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FOLR2

Genetic Association Database (GAD)
FOLR2
Human Genome Epidemiology (HuGE) Navigator
FOLR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOLR2
genes like me logo Genes that share disorders with FOLR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOLR2 Gene

Publications for FOLR2 Gene

  1. Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions. (PMID: 17035141) Boyles A.L. … Speer M.C. (Environ. Health Perspect. 2006) 3 22 25 46 64
  2. Analysis of the human folate receptor beta gene for an association with neural tube defects. (PMID: 12809644) O'Leary V.B. … Brody L.C. (Mol. Genet. Metab. 2003) 3 22 46 64
  3. Proteolysis of the carboxyl-terminal GPI signal independent of GPI modification as a mechanism for selective protein secretion. (PMID: 9398177) Wang J. … Ratnam M. (Biochemistry 1997) 3 4 22 64
  4. Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal. (PMID: 7578066) Yan W. … Ratnam M. (Biochemistry 1995) 3 4 22 64
  5. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 3 46 64

Products for FOLR2 Gene

Sources for FOLR2 Gene

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