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Aliases & Descriptions for FOLR2
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases BETA-HFR 2 FBP 3 FBP/PL-1 2 FR-BETA 2 FR-P3 2 FR-beta 3
Descriptions Folate receptor 2 2 , 3 Folate receptor, fetal/placental 3 Placental folate-binding protein 3 folate receptor 2 (fetal) 2 folate receptor, beta 2 folate-binding protein, fetal/placental 2
Search outside databases for aliases for FOLR2 genePrevious GC identifers: GC11U990040 GC11P073467 GC11P072150 GC11P071654
Summaries for FOLR2 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for FOLR2 : The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genesexist in a cluster on chromosome 11. Members of this gene family have a high affinity for folicacid and for several reduced folic acid derivatives, and they mediate delivery of5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequencehomology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originallythought to be specific to placenta, it can also exist in other tissues, and it may play a role inthe transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multipletranscript variants that encode the same protein have been found for this gene. [provided byRefSeq] UniProtKB/Swiss-Prot: FOLR2_HUMAN, P14207 Function : Binds to folate and reduced folic acid derivatives and mediates delivery of5-methyltetrahydrofolate to the interior of cells
Gene Wiki entry for FOLR2
Genomic Location for FOLR2
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the FOLR2 gene Entrez Gene cytogenetic band: 11q13.3-q13.5 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13.3-q14.1 FOLR2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P071605:
(about GC identifiers )
Start:
71,605,476 bp from pter
End:
71,610,637 bp from pter
Size:
5,162 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000011.8 NT_033927.7 Proteins for FOLR2
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: FOLR2_HUMAN, P14207 (See
protein sequence )Recommended Name: Folate receptor beta precursor Size : 255 amino acids; 29280 Da
Subcellular location : Cell membrane; Lipid-anchor, GPI-anchor. Secreted (Probable)
Post-translational modifications:
Eight disulfide bonds are present (Probable)1
N-glycosylated1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (4 alternative transcripts):
NP_000794.3 NP_001107006.1 NP_001107007.1 NP_001107008.1 ENSEMBL proteins: ENSP00000321957 ENSP00000298223 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 4 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for FOLR2: Assays for FOLR2:
Protein
Domains/ Families for FOLR2(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P14207 ProtoNet protein and cluster: P14207
1 Blocks protein family : IPB004269 Folate receptor UniProtKB/Swiss-Prot: FOLR2_HUMAN, P14207 Similarity : Belongs to the folate receptor family
Gene Function for FOLR2
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
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siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NM_000803 Applied Biosystems Silencer ® siRNAs for FOLR2 Sigma-Aldrich siRNA and siRNA Panels for FOLR2 Sigma-Aldrich shRNA for FOLR2 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 4 ): NM_000803                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 4 ): NM_000803                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_000803  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001113536 UniProtKB/Swiss-Prot: FOLR2_HUMAN, P14207 Function : Binds to folate and reduced folic acid derivatives and mediates delivery of5-methyltetrahydrofolate to the interior of cells
Genatlas biochemistry entry for FOLR2 :folate receptor 2,fetal
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Folr2) :2 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for FOLR2
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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--1 Gene Ontology (GO) biological process term (links to tree view) :
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Drugs & Compounds for FOLR2 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for FOLR2 2 Novoseek chemical compound relationships for FOLR2 gene
About this table
Transcripts for FOLR2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NM_000803 Sigma-Aldrich siRNA and siRNA Panels for FOLR2 Sigma-Aldrich shRNA for FOLR2 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_000803 NM_001113534 NM_001113535 NM_001113536
REFSEQ mRNAs for FOLR2 gene (4 alternative transcripts): NM_000803.4 NM_001113534.1 NM_001113535.1 NM_001113536.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_000803 NM_001113534 NM_001113535 NM_001113536
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4 ): NM_000803                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 4 ): NM_000803                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_000803  
Additional cDNA sequence: AK222539.1 AK222643.1 BC027894.1 BC058036.1 BC115366.1
7 DOTS entries : DT.318460 DT.97839472 DT.101982470 DT.120718746 DT.95112656 DT.120718755 DT.75141285
24/158 AceView cDNA sequences (see all 158
):BI837083 AI214949 CA941056 AI340025 BM705231 AA470442 BM849995 BC058036 AA453901 AA903254 AI356663 BM685600 BF445525 AW024209 R78313 BE466179 AW950250 BX337752 BU581337 BU617900 BC027894 AI742119 AA418932 AA747851
highest scoring ESTs for FOLR2 :J02876 AA009638 AA009912 AA026952 AA033731 AA418843 AA453816 AA453901 AA455948 AA468816
Unigene Cluster for FOLR2: Folate receptor 2 (fetal) Hs.433159 [show with all ESTs ] Unigene Representative Sequence: AK222539 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FOLR2 (see all 8
) ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d SP1 :         -             -         SP2 :         -                     SP3 :         -                     SP4 :         -   -   -                 SP5 :         -   -                  
About this scheme ECgene alternative splicing isoforms for FOLR2 2 Ensembl transcripts including schematic representations : ENST00000321324
ENST00000298223
Expression for FOLR2
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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FOLR2 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for FOLR2 1 / 2 / 3
3 probe-sets matching FOLR2 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GTGGGGCCAASOURCE GeneReport for Unigene cluster: Hs.433159 Expression variation in blood from EXPOLDB for FOLR2
UniProtKB/Swiss-Prot: FOLR2_HUMAN, P14207 Tissue specificity : Expressed in placenta and hematopoietic cells. Expression is increased inmalignant tissues
Orthologs for FOLR2
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for FOLR2 gene from 5 species
About this table Species with no ortholog for FOLR2 ENSEMBL Gene Tree for FOLR2 Paralogs for FOLR2 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for FOLR2 gene FOLR3 2 FOLR1 2 FOLR4 2
SNPs/Variants for FOLR2 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for FOLR2 (up to first 250kb)
Disorders & Mutations for FOLR2
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 136425 4 Novoseek disease relationships for FOLR2 gene
About this table Genetic Association Database: FOLR2 Human Genome Epidemiology Navigator: FOLR2 (4 documents)
Medical News for FOLR2 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for FOLR2 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/52 PubMed articles for FOLR2 gene (see all 52
): Proteolysis of the carboxyl-terminal GPI signal independent of GPI modification as a mechanism for selective protein secretion. (PubMed id 9398177) 1, 3, 4 Wang J.... Ratnam M. (1997) Analysis of the human folate receptor beta gene for an association with neural tube defects. (PubMed id 12809644) 1, 3, 6 O'Leary V.B....Brody L.C. (2003) Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal. (PubMed id 7578066) 1, 3, 4 Yan W. and Ratnam M. (1995) Report of the fourth international workshop on human chromosome 11 mapping 1994. (PubMed id 7698003) 2, 3 van Heyningen V. and Little P.F. (1995) Characterization of the gene encoding a folate-binding protein expressed in human placenta. Identification of promoter activity in a G-rich SP1 site linked with the tandemly repeated GGAAG motif for the ets encoded GA-binding protein. (PubMed id 8106441) 3, 4 Sadasivan E.... Rothenberg S.P. (1994) Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene. (PubMed id 8445646) 3, 4 Page S.T.... Elwood P.C. (1993) Folate coenzyme and antifolate transport proteins in normal and neoplastic cells. (PubMed id 2561247) 3, 4 Freisheim J.H.... Ratnam M. (1989) Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA. (PubMed id 2605182) 3, 4 Ratnam M.... Freisheim J.H. (1989) Modulation of the folate receptor type beta gene by coordinate actions of retinoic acid receptors at activator Sp1/ets and repressor AP-1 sites. (PubMed id 12543860) 1, 3 Hao H....Ratnam M. (2003) Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis. (PubMed id 10446858) 1, 3 Nakashima-Matsushita N....Matsuyama T. (1999)
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Genome Databases showing FOLR2
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing FOLR2
(According to HUGE )
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Specialized Databases showing FOLR2 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for FOLR2 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for FOLR2:
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