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FOLR2 Gene

protein-coding   GIFtS: 64
GCID: GC11P071927

Folate Receptor 2 (Fetal)

  See FOLR2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Folate Receptor 2 (Fetal)1 2     FR-P32
Folate Receptor, Fetal/Placental2 3     Folate Receptor Beta2
Placental Folate-Binding Protein2 3     Folate Receptor, Beta2
FBP2 3     Folate-Binding Protein, Fetal/Placental2
BETA-HFR2     FR-beta3
FBP/PL-12     Folate Receptor 23
FR-BETA2     

External Ids:    HGNC: 37931   Entrez Gene: 23502   Ensembl: ENSG000001654577   OMIM: 1364255   UniProtKB: P142073   

Export aliases for FOLR2 gene to outside databases

Previous GC identifers: GC11U990040 GC11P073467 GC11P072150 GC11P071654 GC11P071605 GC11P068220


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FOLR2 Gene:
The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a
cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced
folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This
protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this
protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a
role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple
transcript variants that encode the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for FOLR2 Gene:
FOLR2 (folate receptor 2 (fetal)) is a protein-coding gene. Diseases associated with FOLR2 include neural tube defects, and rheumatoid arthritis. GO annotations related to this gene include folic acid binding. An important paralog of this gene is FOLR3.

UniProtKB/Swiss-Prot: FOLR2_HUMAN, P14207
Function: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and
folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH.
Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces
its affinity for folates and mediates their release

Gene Wiki entry for FOLR2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FOLR2 gene promoter:
         Max1   AP-1   ATF-2   POU2F1   POU2F1a   POU2F1b   POU2F1c   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOLR2 promoter sequence
   Search Chromatin IP Primers for FOLR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOLR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.3-q13.5   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.3-q14.1

FOLR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOLR2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P071927:  view genomic region     (about GC identifiers)

Start:
71,927,645 bp from pter      End:
71,932,994 bp from pter
Size:
5,350 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FOLR2_HUMAN, P14207 (See protein sequence)
Recommended Name: Folate receptor beta precursor  
Size: 255 amino acids; 29280 Da
5 PDB 3D structures from and Proteopedia for FOLR2:
4KMY (3D)        4KMZ (3D)        4KN0 (3D)        4KN1 (3D)        4KN2 (3D)    

Explore the universe of human proteins at neXtProt for FOLR2: NX_P14207

Explore proteomics data for FOLR2 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn115, Asn195

  • See FOLR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_000794.3  NP_001107006.1  NP_001107007.1  NP_001107008.1  

    ENSEMBL proteins: 
     ENSP00000405638   ENSP00000298223   ENSP00000414094   ENSP00000443307   ENSP00000441547  
     ENSP00000438568   ENSP00000444794   ENSP00000321957   ENSP00000440337  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR018143 Folate_rcpt-like
     IPR004269 Folate_rcpt

    Graphical View of Domain Structure for InterPro Entry P14207

    ProtoNet protein and cluster: P14207

    1 Blocks protein domain: IPB004269 Folate receptor

    UniProtKB/Swiss-Prot: FOLR2_HUMAN, P14207
    Similarity: Belongs to the folate receptor family


    Find genes that share domains with FOLR2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOLR2_HUMAN, P14207
    Function: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and
    folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH.
    Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces
    its affinity for folates and mediates their release
    Induction: Up-regulated by retinoic acid

         Genatlas biochemistry entry for FOLR2:
    folate receptor 2,fetal

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005542folic acid binding IDA4066659
    GO:0008517folic acid transporter activity IDA4066659
         
    Find genes that share ontologies with FOLR2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FOLR2:
     Decreased DCP1a protein expres 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Folr2):
     normal 

    Find genes that share phenotypes with FOLR2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Folr2tm1Fnn for FOLR2

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    hsa-miR-3160-3p
    SwitchGear 3'UTR luciferase reporter plasmidFOLR2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FOLR2_HUMAN, P14207: Cell membrane; Lipid-anchor, GPI-anchor. Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular4
    endosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0016020membrane TAS2605182
    GO:0031362anchored component of external side of plasma membrane IDA4066659

    Find genes that share ontologies with FOLR2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FOLR2 About    
    See pathways by source

    SuperPathContained pathways About
    1Endocytosis
    Endocytosis


    Find genes that share SuperPaths with FOLR2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for FOLR2):
        Endocytosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FOLR2
    Interactions:

        Search GeneGlobe Interaction Network for FOLR2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FOLR2 (P142073 ENSP000002982234) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDR2Q018503, ENSP000002683834I2D: score=1 STRING: ENSP00000268383
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015884folic acid transport IDA4066659

    Find genes that share ontologies with FOLR2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for FOLR2

    1 HMDB Compound for FOLR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Folic acidAcifolic (see all 37)59-30-3--

    1 DrugBank Compound for FOLR2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Folic AcidFolate (see all 9)59-30-3targetbinder16704197 11752352 17035141 16620997

    6 Novoseek inferred chemical compound relationships for FOLR2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    folate 84 118 12840209 (8), 14608093 (7), 14704289 (7), 8844253 (5) (see all 23)
    5-methyltetrahydrofolate 81.6 7 12576066 (2), 12809644 (1), 12840209 (1), 8844253 (1) (see all 5)
    retinoic acid 40.5 21 11071651 (5), 12543860 (4), 16740727 (2), 17708654 (2) (see all 5)
    retinoid 32.7 9 11071651 (3), 12831362 (2)
    methionine 16 1 10332959 (1)
    serine 0 1 17035141 (1)



    Find genes that share compounds with FOLR2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FOLR2 gene (4 alternative transcripts): 
    NM_000803.4  NM_001113534.1  NM_001113535.1  NM_001113536.1  

    Unigene Cluster for FOLR2:

    Folate receptor 2 (fetal)
    Hs.433159  [show with all ESTs]
    Unigene Representative Sequence: AK222539
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000449475 ENST00000298223(uc009yte.3 uc009ytf.3 uc009ytd.3 uc001ose.4)
    ENST00000454954 ENST00000541003 ENST00000539412 ENST00000536778 ENST00000535625
    ENST00000321324 ENST00000538353
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK222539.1 AK222643.1 BC027894.1 BC058036.1 BC115366.1 

    7 DOTS entries:

    DT.318460  DT.97839472  DT.101982470  DT.120718746  DT.120718755  DT.75141285  DT.95112656 

    Selected AceView cDNA sequences (see all 158):

    AI340025 BM685600 BC027894 AW024209 AI214949 BU617900 BC058036 BF445525 
    AA470442 AA418932 BX337752 BE466179 AI356663 BM849995 AA903254 AA453901 
    BU581337 AA829923 AI742119 AA747851 R78313 BM705231 CA941056 AW950250 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FOLR2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:                          -                                   -                     
    SP2:                          -                                                         
    SP3:                          -                                                         
    SP4:                          -     -     -                                             
    SP5:                          -     -                                                   


    ECgene alternative splicing isoforms for FOLR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FOLR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGGGCCAA
    FOLR2 Expression
    About this image


    FOLR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Heart (Cardiovascular System)
    FOLR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FOLR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.433159

    UniProtKB/Swiss-Prot: FOLR2_HUMAN, P14207
    Tissue specificity: Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FOLR2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Folr21 , 5 folate receptor 2 (fetal)1, 5 80.74(n)1
    82.22(a)1
      7 (54.67 cM)5
    142761  NM_008035.21  NP_032061.11 
     1018399905 
    chicken
    (Gallus gallus)
    Aves FOLR16
    Gallus gallus folate receptor 1 (adult) (FOLR1), m...
    54(a)
    1 → many
    1(193685559-193688956) ENSGALG00000017343
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    73(a)
    1 → many
    AAWZ02038598(1643-1834)
    zebrafish
    (Danio rerio)
    Actinopterygii FOLR16
    folate receptor 1 (adult)
    55(a)
    1 → many
    15(46932044-46938985) ENSDARG00000075659


    ENSEMBL Gene Tree for FOLR2 (if available)
    TreeFam Gene Tree for FOLR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FOLR2 gene
    FOLR32  FOLR42  FOLR12  
    3 SIMAP similar genes for FOLR2 using alignment to 12 protein entries:     FOLR2_HUMAN (see all proteins):
    FOLR1    FOLR3    FOLR4

    Find genes that share paralogs with FOLR2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FOLR2 (see all 198)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364084
    A breast cancer sample4--see VAR_0364082 H N mis40--------
    rs1397724571,2
    --71925942(+) GGACAA/TTCAAC 4 -- us2k10--------
    rs1172239071,2
    C,F--71926022(+) TAAAAG/TAATAC 4 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1493614631,2
    C--71926116(+) GCTAAA/TAAGCA 4 -- us2k10--------
    rs781909171,2
    C,F--71926136(-) ATGCTG/AAGCGT 4 -- us2k12Minor allele frequency- A:0.50NA 4
    rs1175373841,2
    C,F--71926151(+) AATTAT/GTAGAG 4 -- us2k11Minor allele frequency- G:0.03NA 120
    rs746030101,2
    C,F--71926242(+) GAAATA/GAGTGT 4 -- us2k13Minor allele frequency- G:0.06WA NA EA 358
    rs1136323811,2
    C--71926293(+) GATGG-/AAATGTA 4 -- us2k11Minor allele frequency- AA:0.00CSA 2
    rs757908081,2
    C,F--71926326(+) AAACAG/CTGTGG 4 -- us2k12Minor allele frequency- C:0.06WA NA 238
    rs1887285251,2
    --71926369(+) TATAAC/TCCTGC 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for FOLR2 (71927645 - 71932994 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FOLR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1221n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FOLR2
    DNA2.0 Custom Variant and Variant Library Synthesis for FOLR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 136425    OMIM disorders: --

    2 diseases for FOLR2:    
    About MalaCards
    neural tube defects    rheumatoid arthritis

    1 disease from the University of Copenhagen DISEASES database for FOLR2:
    Ovarian cancer

    Find genes that share disorders with FOLR2           About GenesLikeMe

    5 Novoseek inferred disease relationships for FOLR2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neural tube defects 66 2 12809644 (2)
    myeloid leukemia 57.2 7 11071651 (3), 18318652 (2), 10023702 (1)
    lymphoblastic leukemia acute 21.5 2 8110752 (1), 10023702 (1)
    leukemia 0 2 10023702 (2)
    tumors 0 2 19951991 (2)

    Genetic Association Database (GAD): FOLR2
    Human Genome Epidemiology (HuGE) Navigator: FOLR2 (14 documents)

    Export disorders for FOLR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for FOLR2 gene, integrated from 10 sources (see all 72):
    (articles sorted by number of sources associating them with FOLR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions. (PubMed id 17035141)1, 4, 7, 9 Boyles A.L....Speer M.C. (Environ. Health Perspect. 2006)
    2. Proteolysis of the carboxyl-terminal GPI signal independent of GPI modification as a mechanism for selective protein secretion. (PubMed id 9398177)1, 2, 9 Wang J.... Ratnam M. (Biochemistry 1997)
    3. Analysis of the human folate receptor beta gene for an association with neural tube defects. (PubMed id 12809644)1, 4, 9 O'Leary V.B....Brody L.C. (Mol. Genet. Metab. 2003)
    4. Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal. (PubMed id 7578066)1, 2, 9 Yan W. and Ratnam M. (Biochemistry 1995)
    5. Association of folate receptor (FOLR1, FOLR2, FOLR3) and reduced folate carrier (SLC19A1) genes with meningomyelocele. (PubMed id 20683905)1, 4 O'Byrne M.R....Northrup H. (Birth Defects Res. Part A Clin. Mol. Teratol. 2010)
    6. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    7. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PubMed id 19161160)1, 4 Franke B....Blom H.J. (Birth Defects Res. Part A Clin. Mol. Teratol. 2009)
    10. Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study. (PubMed id 19048631)1, 4 Boyles A.L....Lie R.T. (Genet. Epidemiol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 2350 HGNC: 3793 AceView: FOLR2 Ensembl:ENSG00000165457 euGenes: HUgn2350
    ECgene: FOLR2 Kegg: 2350 H-InvDB: FOLR2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FOLR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FOLR2 gene:
    Search GeneIP for patents involving FOLR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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