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FOLR2 Gene

protein-coding   GIFtS: 59

GC11P071605
folate receptor 2 (fetal)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
BETA-HFR 2
FBP 3
FBP/PL-1 2
FR-BETA 2
FR-P3 2
FR-beta 3
Descriptions
Folate receptor 2 2, 3
Folate receptor, fetal/placental 3
Placental folate-binding protein 3
folate receptor 2 (fetal) 2
folate receptor, beta 2
folate-binding protein, fetal/placental 2
External Ids
HGNC: 37931
Entrez Gene: 23502
UniProtKB: P142073
Ensembl: ENSG000001654577
Search outside databases for aliases for FOLR2 gene

Previous GC identifers: GC11U990040 GC11P073467 GC11P072150 GC11P071654

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FOLR2:
The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes
exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic
acid and for several reduced folic acid derivatives, and they mediate delivery of
5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence
homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally
thought to be specific to placenta, it can also exist in other tissues, and it may play a role in
the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple
transcript variants that encode the same protein have been found for this gene. [provided by
RefSeq]

UniProtKB/Swiss-Prot: FOLR2_HUMAN, P14207
Function: Binds to folate and reduced folic acid derivatives and mediates delivery of
5-methyltetrahydrofolate to the interior of cells

Gene Wiki entry for FOLR2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the FOLR2 gene  

Entrez Gene cytogenetic band: 11q13.3-q13.5   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.3-q14.1

FOLR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P071605:     (about GC identifiers)

Start:
71,605,476 bp from pter
End:
71,610,637 bp from pter
Size:
5,162 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000011.8  NT_033927.7  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FOLR2_HUMAN, P14207 (See protein sequence)
Recommended Name: Folate receptor beta precursor  
Size: 255 amino acids; 29280 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor. Secreted (Probable)

Post-translational modifications:

  • Eight disulfide bonds are present (Probable)1
  • N-glycosylated1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (4 alternative transcripts): 
    NP_000794.3  NP_001107006.1  NP_001107007.1  NP_001107008.1  


    ENSEMBL proteins: 
    ENSP00000321957 ENSP00000298223 


    Human Recombinant Proteins 
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    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (FOLR2)
    Human Recombinant Proteins from Abnova (FOLR2)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005624 membrane fraction TAS2605182
    GO:0005886 plasma membrane IEA--
    GO:0031225 anchored to membrane IEA--
    About this table

    Antibodies for FOLR2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for FOLR2
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (FOLR2), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (FOLR2)
    Novus Biologicals Antibody for FOLR2

    Assays for FOLR2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR018143 Folate_rcpt_cons-reg
     IPR004269 Folate_rcpt


       GeneDecks  FOLR2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P14207

    ProtoNet protein and cluster: P14207

    1 Blocks protein family: IPB004269 Folate receptor

    UniProtKB/Swiss-Prot: FOLR2_HUMAN, P14207
    Similarity: Belongs to the folate receptor family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (FOLR2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (FOLR2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_000803

                  Applied Biosystems Silencer® siRNAs for FOLR2

                  Sigma-Aldrich siRNA and siRNA Panels for FOLR2  
                         Sigma-Aldrich shRNA for FOLR2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for FOLR2
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000803
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000803
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_000803 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001113536

    UniProtKB/Swiss-Prot: FOLR2_HUMAN, P14207
    Function: Binds to folate and reduced folic acid derivatives and mediates delivery of
    5-methyltetrahydrofolate to the interior of cells

    Genatlas biochemistry entry for FOLR2:
    folate receptor 2,fetal

    1 MGI mutant phenotype (inferred from 1 allele(MGI details for Folr2):

    normal

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872 receptor activity IEA--
    GO:0005542 folic acid binding TAS2605182
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015884 folic acid transport TAS2605182
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for FOLR2
    2 Novoseek chemical compound relationships for FOLR2 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-methyltetrahydrofolate 82.59 7 12576066 (2), 12809644 (1), 12840209 (1), 8844253 (1) (see all 5)
    methionine 18.04 1 10332959 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (FOLR2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (FOLR2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_000803

                  Sigma-Aldrich siRNA and siRNA Panels for FOLR2  
                         Sigma-Aldrich shRNA for FOLR2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_000803  NM_001113534  NM_001113535  NM_001113536  

    REFSEQ mRNAs for FOLR2 gene (4 alternative transcripts): 

    NM_000803.4   NM_001113534.1   NM_001113535.1   NM_001113536.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_000803  NM_001113534  NM_001113535  NM_001113536  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000803
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000803
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_000803 

    Additional cDNA sequence: 

    AK222539.1 AK222643.1 BC027894.1 BC058036.1 BC115366.1 

    7 DOTS entries:

    DT.318460  DT.97839472  DT.101982470  DT.120718746  DT.95112656  DT.120718755  DT.75141285 

    24/158 AceView cDNA sequences (see all 158 ):

    BI837083 AI214949 CA941056 AI340025 BM705231 AA470442 BM849995 BC058036 
    AA453901 AA903254 AI356663 BM685600 BF445525 AW024209 R78313 BE466179 
    AW950250 BX337752 BU581337 BU617900 BC027894 AI742119 AA418932 AA747851 

    highest scoring ESTs for FOLR2:

    J02876 AA009638 AA009912 AA026952 AA033731 AA418843 AA453816 AA453901 AA455948 AA468816 

    Unigene Cluster for FOLR2:

    Folate receptor 2 (fetal)
    Hs.433159  [show with all ESTs]
    Unigene Representative Sequence: AK222539


    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FOLR2 (see all 8 )

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:                          -                                   -                     
    SP2:                          -                                                         
    SP3:                          -                                                         
    SP4:                          -     -     -                                             
    SP5:                          -     -                                                   

    About this scheme

    ECgene alternative splicing isoforms for FOLR2

    2 Ensembl transcripts including schematic representations:
    ENST00000321324  ENST00000298223  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    FOLR2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for FOLR2

    1 / 2 / 3

    3 probe-sets matching FOLR2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    33871_s_at2, 3 U95-A 3 1.00 0.74 1.00 1.00 J02876 1.00 0.90 0.95 1

    204829_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000803 0.60 0.83 0.73 1

    204829_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  FOLR2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GTGGGGCCAA

    SOURCE GeneReport for Unigene cluster: Hs.433159

    Expression variation in blood from EXPOLDB for FOLR2

    UniProtKB/Swiss-Prot: FOLR2_HUMAN, P14207
    Tissue specificity: Expressed in placenta and hematopoietic cells. Expression is increased in
    malignant tissues

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for FOLR2 gene from 5 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    FOLR21   -- folate receptor 2 (fetal) 85.14(n)
    79.46(a)
    476816  XM_534020.2  XP_534020.2 
    chimpanzee
    (Pan troglodytes)
    FOLR21   -- folate receptor 2 (fetal) 99.02(n)
    98.9(a)
    451401  XM_001174682.1  XP_001174682.1 
    cow
    (Bos taurus)
    FOLR21   -- folate receptor 2 (fetal) 82.6(n)
    80.08(a)
    507672  NM_001075325.1  NP_001068793.1 
    rat
    (Rattus norvegicus)
    Folr21   -- folate receptor 2 (fetal) 79.33(n)
    78.8(a)
    293154  XM_215013.4  XP_215013.4 
    mouse
    (Mus musculus)
    Folr21, 5 75
    folate receptor 2 (fetal)1, 5 78.88(n)1
    78.09(a)1
    142761  NM_008035.11  NP_032061.11 
     AV0503745  BC0221085  (see all 7)
    About this table        Species with no ortholog for FOLR2

    ENSEMBL Gene Tree for FOLR2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for FOLR2 gene
    FOLR32  FOLR12  FOLR42  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/29 NCBI SNPs in FOLR2 are shown (see all 29 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 29)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs6519331,2
    C,F,H71604308(+) cacttA/Ggacaa 1 -- ng5112Minor allele frequency- G:0.44EU EA WA NA 1054
    rs112681,2
    C,H71610357(+) CTATGC/ATGCAG 4 D/A mis1 ese35Minor allele frequency- A:0.00EU EA WA 572
    rs112354691,2
    C,H71605116(+) TGAAGC/TTCAGT 1 -- ng514Minor allele frequency- T:0.00EU EA WA 420
    --
    rs18035691,2
    C71609947(+) GGATTG/TTCACA 4 C/F mis11Minor allele frequency- T:0.00EA 172
    rs122745201,2
    H71604145(+) ggtccA/Cttgat 1 -- ng51 tfbs34Minor allele frequency- C:0.00EU EA WA 398
    rs5149331,2
    A,C,F,H,O71607855(-) CTGTCA/GCCCAC 1 -- int16Minor allele frequency- G:0.40MN EU EA WA 772
    rs6516461,2
    A,C,F,H71607174(+) TAGGGA/TTGGGG 1 -- int18Minor allele frequency- T:0.48EA NA EU WA 644
    rs22984441,2
    A,C,F71610062(-) CTTGAA/GGATTT 1 -- int15Minor allele frequency- G:0.32EA NA 1830
    --
    rs118280611,2
    C71608631(+) gcctcC/Tggggt 1 -- int10--------
    --
    rs716688071,2
    --71610465(+) GTCCT-/CCCAGA 4 -- ut310--------
    About this table

    HapMap Linkage Disequilibrium images for FOLR2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 136425

    4 Novoseek disease relationships for FOLR2 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    neural tube defects 67.41 2 12809644 (2)
    myeloid leukemia 58.78 7 11071651 (3), 18318652 (2), 10023702 (1)
    lymphoblastic leukemia acute 23.82 2 8110752 (1), 10023702 (1)
    leukemia 0.00 2 10023702 (2)
    About this table

    Genetic Association Database: FOLR2
    Human Genome Epidemiology Navigator: FOLR2 (4 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/52 PubMed articles for FOLR2 gene (see all 52 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 2350 HGNC: 3793 AceView: FOLR2 Ensembl:ENSG00000165457 euGenes: HUgn2350
    ECgene: FOLR2 H-InvDB: FOLR2
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for FOLR2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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