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Aliases for FOLR2 Gene

Aliases for FOLR2 Gene

  • Folate Receptor 2 (Fetal) 2 3
  • Folate Receptor, Fetal/Placental 3 4
  • Placental Folate-Binding Protein 3 4
  • FR-BETA 3 4
  • FBP 3 4
  • Folate-Binding Protein, Fetal/Placental 3
  • Folate Receptor, Beta 3
  • Folate Receptor 2 4
  • BETA-HFR 3
  • FBP/PL-1 3
  • FR-P3 3

External Ids for FOLR2 Gene

Previous GeneCards Identifiers for FOLR2 Gene

  • GC11U990040
  • GC11P073467
  • GC11P072150
  • GC11P071654
  • GC11P071605
  • GC11P071927
  • GC11P068220

Summaries for FOLR2 Gene

Entrez Gene Summary for FOLR2 Gene

  • The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOLR2 Gene

FOLR2 (Folate Receptor 2 (Fetal)) is a Protein Coding gene. Diseases associated with FOLR2 include thiamine metabolism dysfunction syndrome 2 and neural tube defects. Among its related pathways are Endocytosis. GO annotations related to this gene include folic acid binding and folic acid transporter activity. An important paralog of this gene is FOLR1.

UniProtKB/Swiss-Prot for FOLR2 Gene

  • Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.

Gene Wiki entry for FOLR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOLR2 Gene

Genomics for FOLR2 Gene

Regulatory Elements for FOLR2 Gene

Genomic Location for FOLR2 Gene

Chromosome:
11
Start:
72,216,601 bp from pter
End:
72,221,950 bp from pter
Size:
5,350 bases
Orientation:
Plus strand

Genomic View for FOLR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOLR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOLR2 Gene

Proteins for FOLR2 Gene

  • Protein details for FOLR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14207-FOLR2_HUMAN
    Recommended name:
    Folate receptor beta
    Protein Accession:
    P14207
    Secondary Accessions:
    • Q05CA5
    • Q6GTE8

    Protein attributes for FOLR2 Gene

    Size:
    255 amino acids
    Molecular mass:
    29280 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FOLR2 Gene

neXtProt entry for FOLR2 Gene

Proteomics data for FOLR2 Gene at MOPED

Post-translational modifications for FOLR2 Gene

Antibody Products

No data available for DME Specific Peptides for FOLR2 Gene

Domains & Families for FOLR2 Gene

Protein Domains for FOLR2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FOLR2 Gene

Graphical View of Domain Structure for InterPro Entry

P14207

UniProtKB/Swiss-Prot:

FOLR2_HUMAN :
  • Belongs to the folate receptor family.
Family:
  • Belongs to the folate receptor family.
genes like me logo Genes that share domains with FOLR2: view

No data available for Gene Families for FOLR2 Gene

Function for FOLR2 Gene

Molecular function for FOLR2 Gene

GENATLAS Biochemistry:
folate receptor 2,fetal
UniProtKB/Swiss-Prot Function:
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
UniProtKB/Swiss-Prot Induction:
Up-regulated by retinoic acid.

Gene Ontology (GO) - Molecular Function for FOLR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005542 folic acid binding IDA 4066659
GO:0008144 drug binding IPI 19116913
GO:0008517 folic acid transporter activity IDA 4066659
GO:0051870 methotrexate binding IDA 19116913
GO:0061714 folic acid receptor activity IC 19116913
genes like me logo Genes that share ontologies with FOLR2: view
genes like me logo Genes that share phenotypes with FOLR2: view

Animal Models for FOLR2 Gene

MGI Knock Outs for FOLR2:

Animal Model Products

miRNA for FOLR2 Gene

miRTarBase miRNAs that target FOLR2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOLR2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FOLR2 Gene

Localization for FOLR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOLR2 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOLR2 Gene COMPARTMENTS Subcellular localization image for FOLR2 gene
Compartment Confidence
plasma membrane 5
extracellular 3

Gene Ontology (GO) - Cellular Components for FOLR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0009986 cell surface IDA 25015955
GO:0016020 membrane TAS 2605182
GO:0031362 anchored component of external side of plasma membrane IDA 4066659
genes like me logo Genes that share ontologies with FOLR2: view

Pathways & Interactions for FOLR2 Gene

SuperPathways for FOLR2 Gene

Superpath Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with FOLR2: view

Pathways by source for FOLR2 Gene

1 KEGG pathway for FOLR2 Gene

Interacting Proteins for FOLR2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000298223%0d%0a9606.ENSP00000268383%0d%0a
Selected Interacting proteins: P14207-FOLR2_HUMAN ENSP00000298223 for FOLR2 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for FOLR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 NOT monocyte chemotaxis IDA 25015955
GO:0006898 receptor-mediated endocytosis IC 19116913
GO:0006954 inflammatory response NAS 25015955
GO:0008284 positive regulation of cell proliferation IMP 19116913
GO:0015884 folic acid transport IDA 4066659
genes like me logo Genes that share ontologies with FOLR2: view

No data available for SIGNOR curated interactions for FOLR2 Gene

Drugs & Compounds for FOLR2 Gene

(6) Drugs for FOLR2 Gene - From: NovoSeek, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Folic Acid Approved Nutra Target, binder 2851
5-methyltetrahydrofolate Experimental Pharma 0
EC145 Investigational Pharma Target 0
Folate Nutra 2851
methionine Nutra 70

(2) Additional Compounds for FOLR2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
retinoic acid
302-79-4
Retinoid
genes like me logo Genes that share compounds with FOLR2: view

Transcripts for FOLR2 Gene

Unigene Clusters for FOLR2 Gene

Folate receptor 2 (fetal):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOLR2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOLR2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - -
SP2: -
SP3: -
SP4: - - -
SP5: - -
SP6:
SP7: - -
SP8: - -

Relevant External Links for FOLR2 Gene

GeneLoc Exon Structure for
FOLR2
ECgene alternative splicing isoforms for
FOLR2

Expression for FOLR2 Gene

mRNA expression in normal human tissues for FOLR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOLR2 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x5.7) and Adipose - Subcutaneous (x4.0).

Protein differential expression in normal tissues from HIPED for FOLR2 Gene

This gene is overexpressed in Oral epithelium (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FOLR2 Gene



SOURCE GeneReport for Unigene cluster for FOLR2 Gene Hs.433159

mRNA Expression by UniProt/SwissProt for FOLR2 Gene

P14207-FOLR2_HUMAN
Tissue specificity: Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues.
genes like me logo Genes that share expression patterns with FOLR2: view

Protein tissue co-expression partners for FOLR2 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for FOLR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOLR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOLR2 35
  • 83.55 (n)
  • 81.82 (a)
FOLR2 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOLR2 35
  • 84.85 (n)
  • 79.05 (a)
FOLR2 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Folr2 35
  • 80.74 (n)
  • 82.22 (a)
Folr2 16
Folr2 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOLR2 35
  • 98.95 (n)
  • 98.82 (a)
FOLR2 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Folr2 35
  • 81.71 (n)
  • 82.74 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 22 (a)
ManyToMany
chicken
(Gallus gallus)
Aves FOLR1 36
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 73 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii FOLR1 36
  • 55 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
Species with no ortholog for FOLR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOLR2 Gene

ENSEMBL:
Gene Tree for FOLR2 (if available)
TreeFam:
Gene Tree for FOLR2 (if available)

Paralogs for FOLR2 Gene

Paralogs for FOLR2 Gene

genes like me logo Genes that share paralogs with FOLR2: view

Variants for FOLR2 Gene

Sequence variations from dbSNP and Humsavar for FOLR2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs11268 -- 72,221,665(+) CTATG(A/C)TGCAG missense, reference
rs13908 -- 72,218,687(+) ATGCC(A/G)AGCAC reference, missense
rs514933 -- 72,219,163(-) CTGTC(A/G)CCCAC intron-variant
rs651646 -- 72,218,482(+) TAGGG(A/T)TGGGG intron-variant
rs651933 -- 72,215,616(+) cactt(A/G)gacaa upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FOLR2 Gene

Variant ID Type Subtype PubMed ID
dgv1221n71 CNV Loss 21882294

Variation tolerance for FOLR2 Gene

Residual Variation Intolerance Score: 82.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOLR2 Gene

HapMap Linkage Disequilibrium report
FOLR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOLR2 Gene

Disorders for FOLR2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FOLR2 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
thiamine metabolism dysfunction syndrome 2
  • biotin-responsive basal ganglia disease
neural tube defects
  • spina bifida
rheumatoid arthritis
  • rheumatoid arthritis, progression of
- elite association
Search FOLR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FOLR2

Genetic Association Database (GAD)
FOLR2
Human Genome Epidemiology (HuGE) Navigator
FOLR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOLR2
genes like me logo Genes that share disorders with FOLR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOLR2 Gene

Publications for FOLR2 Gene

  1. Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions. (PMID: 17035141) Boyles A.L. … Speer M.C. (Environ. Health Perspect. 2006) 23 25 26 67
  2. Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism. (PMID: 19732866) Steinfeld R. … Gaertner J. (Am. J. Hum. Genet. 2009) 23 67
  3. Targeting tumor-associated macrophages in an experimental glioma model with a recombinant immunotoxin to folate receptor beta. (PMID: 19238383) Nagai T. … Matsuyama T. (Cancer Immunol. Immunother. 2009) 23 67
  4. Folate receptor beta is expressed by tumor-associated macrophages and constitutes a marker for M2 anti-inflammatory/regulatory macrophages. (PMID: 19951991) Puig-KrAPger A. … CorbA- A.L. (Cancer Res. 2009) 23 67
  5. Targeted drug delivery via folate receptors. (PMID: 18318652) Zhao X. … Lee R.J. (Expert Opin Drug Deliv 2008) 23 67

Products for FOLR2 Gene

Sources for FOLR2 Gene

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