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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FOLR1 Gene

protein-coding   GIFtS: 65
GCID: GC11P071900

folate receptor 1 (adult)


(Previous symbol: FOLR)
 Explore 50 diseases affiliated with
FOLR1 via
MalaCards
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 Human Malady Compendium 
Biological research products
for FOLR1    

Aliases
for FOLR1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Folate Receptor 1 (Adult)1 2     FR-Alpha1
FOLR1 2 3     KB Cells FBP2 3
Adult Folate-Binding Protein2 3     Folate Binding Protein2
Folate Receptor, Adult2 3     Folate Receptor Alpha2
Ovarian Tumor-Associated Antigen MOv182 3     Folate Receptor 13
FBP2 3     

External Ids:    HGNC: 37911   Entrez Gene: 23482   Ensembl: ENSG000001101957   OMIM: 1364305   UniProtKB: P153283   

Export aliases for FOLR1 gene to outside databases

Previous GC identifers: GC11P074232 GC11P073440 GC11P072123 GC11P071626 GC11P071578 GC11P068193


Summaries
for FOLR1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FOLR1:
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid
and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted
protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form.
Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to
the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript
variants encoding the same protein have been found for this gene. (provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: FOLR1_HUMAN, P15328
Function: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the
interior of cells

Gene Wiki entry for FOLR1 (Folate receptor 1)


Genomic Views
for FOLR1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FOLR1 gene promoter:
         GR   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FOLR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FOLR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOLR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.3-q14.1   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.3-q14.1

FOLR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOLR1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P071900:  view genomic region     (about GC identifiers)

Start:
 71,900,602 bp from pter      End:
 71,907,367 bp from pter
Size:
 6,766 bases      Orientation:
 plus strand

Proteins
for FOLR1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FOLR1_HUMAN, P15328 (See protein sequence)
Recommended Name: Folate receptor alpha precursor  
Size: 257 amino acids; 29819 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor. Secreted (Probable)
Secondary accessions: Q53EW2 Q6FGT8 Q6LC90 Q9UCT2

Explore the universe of human proteins at neXtProt for FOLR1: NX_P15328

Post-translational modifications:

  • Eight disulfide bonds are present (Probable)1
  • The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis
    • catalyzed by a metalloprotease1
  • View neXtProt modification sites for NX_P15328

    • FOLR1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_000793.1  NP_057936.1  NP_057937.1  NP_057941.1  

    ENSEMBL proteins: 
     ENSP00000308137   ENSP00000377286   ENSP00000377284   ENSP00000377281  

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    Uscn Proteins for FOLR1

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005624membrane fraction ----
    GO:0005886plasma membrane NAS1840502
    GO:0005887integral to plasma membrane TAS10633085
    GO:0016020membrane TAS2768245


    FOLR1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for FOLR1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FOLR1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR018143 Folate_rcpt-like
     IPR004269 Folate_rcpt

    Graphical View of Domain Structure for InterPro Entry P15328

    ProtoNet protein and cluster: P15328

    1 Blocks protein family: IPB004269 Folate receptor

    UniProtKB/Swiss-Prot: FOLR1_HUMAN, P15328
    Similarity: Belongs to the folate receptor family


    Function
    for FOLR1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FOLR1_HUMAN, P15328
    Function: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the
    interior of cells

         Genatlas biochemistry entry for FOLR1:
    folate receptor 1,adult

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS10633085
    GO:0005542folic acid binding NAS1840502


    FOLR1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for FOLR1:
     Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Folr1tm1Fnn for FOLR1
         12 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Folr1):
     cellular  craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  hearing/vestibular/ear  homeostasis/metabolism  mortality/aging  nervous system 
     tumorigenesis  vision/eye 

    FOLR1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FOLR1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Endocytosis
    		Endocytosis1.00
    2Pravastatin Pathway, Pharmacokinetics
    		Methotrexate Pathway, Pharmacokinetics0.47

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 PharmGKB Pathway for FOLR1
        Methotrexate Pathway, Pharmacokinetics

    1         Kegg Pathway  (Kegg details for FOLR1):
        Endocytosis


    FOLR1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOLR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for FOLR1 (P153283 ENSP000003081374) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LYNP079483I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    CUL3ENSP000002644144STRING: ENSP00000264414
    IRAK3ENSP000002612334STRING: ENSP00000261233
    NCAPH2ENSP000004100884STRING: ENSP00000410088
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006898receptor-mediated endocytosis TAS9545095
    GO:0008219cell death IEA--
    GO:0015884folic acid transport TAS9545095
    GO:0046655folic acid metabolic process IEA--


    FOLR1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FOLR1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FOLR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for FOLR1

    1 HMDB Compound for FOLR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Folic acidAcifolic (see all 37)59-30-3--
    10/25 Novoseek chemical compound relationships for FOLR1 gene (see all 25)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    folate 92.9 606 9791067 (7), 9426700 (6), 19056550 (5), 18776693 (5) (see all 99)
    5-methyltetrahydrofolate 87.3 19 15094208 (2), 9099956 (2), 9178098 (2), 14704289 (2) (see all 12)
    lometrexol 81.3 2 7508451 (2)
    methotrexate 63.3 41 7511899 (4), 7713875 (4), 17473184 (2), 2253202 (2) (see all 16)
    leucovorin 59 2 15585634 (1), 7579732 (1)
    tomudex 56.8 1 10699949 (1)
    probenecid 52.7 1 9178098 (1)
    homocysteine 47.3 6 11169018 (1), 15641086 (1), 16453285 (1), 19324355 (1)
    trimetrexate 45.7 3 12416030 (2)
    dihydrofolate 43.4 2 17534577 (1), 12416030 (1)

    Search CenterWatch for drugs/clinical trials and news about FOLR1 

    Transcripts
    for FOLR1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FOLR1 gene (5 alternative transcripts): 
    NM_000802.3  NM_016724.2  NM_016725.2  NM_016729.2  NM_016730.1  

    Unigene Cluster for FOLR1:

    Folate receptor 1 (adult)
    Hs.73769  [show with all ESTs]
    Unigene Representative Sequence: X62753
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312293(uc001orz.2 uc001osa.2) ENST00000393681 ENST00000393679
    ENST00000393676(uc001osb.2 uc001osd.2)

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    hsa-miR-29b-1*
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF000381.2 AK223527.1 BC002947.2 BT007158.1 CR542019.1 J05013.1 M25317.1 M28099.1 
    S73474.1 U78793.1 U78794.1 X62753.1 

    5 DOTS entries:

    DT.100770176  DT.447922  DT.95103787  DT.100770180  DT.100770179 

    24/185 AceView cDNA sequences (see all 185):

    U78793 CA944604 AA291206 CR623060 BI913499 R26895 AA488506 R24620 
    CB242517 N29700 CR607460 NM_016730 BG433386 NM_016729 BC002947 AA669286 
    BG328933 AA425789 S73474 BE744857 M28099 AA436422 BE901231 NM_016731 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FOLR1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:              -                                       
    SP2:              -     -                                 
    SP3:                                                      


    ECgene alternative splicing isoforms for FOLR1

    Expression
    for FOLR1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FOLR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCGGGCCTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FOLR1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Endoderm progenitor-like cells (Generation and expan...)
    Primitive gut tube-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FOLR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FOLR1

    SOURCE GeneReport for Unigene cluster: Hs.73769

    UniProtKB/Swiss-Prot: FOLR1_HUMAN, P15328
    Tissue specificity: Exclusively expressed in tissues of epithelial origin. Expression is increased in malignant
    tissues. Expressed in kidney, lung and cerebellum

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    In Situ
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    Orthologs
    for FOLR1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for FOLR1 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FOLR11 folate receptor 1 (adult) 69.29(n)
    66.2(a)    		   395638  NM_204834.1  NP_990165.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 75(a)
    		 1 → many
    		 AAWZ02038598(1643-1834)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia MGC760482 hypothetical protein MGC76048 78.28(n)    BC062496.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1655021 zgc:165502 61.16(n)
    52.54(a)    		   100073336  NM_001098772.1  NP_001092242.1 


    ENSEMBL Gene Tree for FOLR1 (if available)
    TreeFam Gene Tree for FOLR1 (if available) 

    Paralogs
    for FOLR1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FOLR1 gene
    FOLR32  FOLR42  FOLR22  
    3 SIMAP similar genes for FOLR1 using alignment to 1 protein entry:     FOLR1_HUMAN:
    FOLR2    FOLR4    FOLR3

    FOLR1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FOLR1
    PGOHUM00000242789


    Genomic Variants
    for FOLR1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/173 NCBI SNPs in FOLR1 are shown (see all 173)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1219184051,2
    		Cpathogenic71906498(+) GGATCC/TAGCAG 8 Q * stg10--------
    rs1219184061,2
    		Cpathogenic71906972(+) GCCTGA/CCAACC 8 * C stg10--------
    rs1874871711,2
    		--71898628(+) GTTTCC/GAACTC 2 -- us2k10--------
    rs1474208431,2
    		--71898661(+) TCTCGA/GCCTCC 2 -- us2k10--------
    rs1919988911,2
    		--71898991(+) ACACGA/GCACTC 3 -- us2k10--------
    rs1848606641,2
    		--71899069(+) GCGGCC/TCACAC 3 -- us2k10--------
    rs1892834021,2
    		--71899196(+) CAGGCA/CTGGTG 3 -- us2k10--------
    rs1131076731,2
    		C,--71899266(+) GGAGGC/TGGAGG 3 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1808788891,2
    		--71899369(+) AAAATG/TAATGT 3 -- us2k10--------
    rs1841259011,2
    		--71899464(+) CATTCA/GTAGCT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for FOLR1 (71900602 - 71907367 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FOLR1: --
    Human Gene Mutation Database (HGMD): FOLR1

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    Disorders / Diseases
    for FOLR1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FOLR1 for disorders           About GeneDecksing

    OMIM gene information: 136430   
    OMIM disorders: 613068  
    UniProtKB/Swiss-Prot: FOLR1_HUMAN, P15328
  • Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD)
    • [MIM:613068]. NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.
    Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and
    leukodystrophy. Note=Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse
    the clinical symptoms and improve brain abnormalities and function

    20/50 diseases for FOLR1 (see all 50):    About MalaCards
    neurodegeneration    cerebritis    neural tube defect    patent ductus arteriosus
    spina bifida    acute necrotizing encephalitis    malignant pleural mesothelioma    anencephaly
    intraocular lymphoma    spastic paraplegia    pediatric osteosarcoma    paraplegia
    cerebellar ataxia    ovarian cancer    breast-ovarian cancer    epithelial ovarian cancer
    pituitary adenoma    spasticity    leukodystrophy    choriocarcinoma

    2 diseases from the University of Copenhagen DISEASES database for FOLR1:
    Ovarian cancer     Acute necrotizing encephalitis

    10/26 Novoseek disease relationships for FOLR1 gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    folate deficiency 71.9 4 9301457 (2), 8126512 (1), 15641086 (1)
    ovarian carcinoma 71.6 46 9426700 (4), 19454358 (4), 9218736 (4), 8242637 (3) (see all 20)
    ovarian cancer 56.9 27 19617914 (5), 19585555 (3), 1717147 (2), 16908932 (2) (see all 16)
    leukemia l1210 55.4 1 7579732 (1)
    anencephaly 43.2 1 17035141 (1)
    tumors 38.3 64 19585555 (5), 18222534 (5), 16453285 (4), 12874029 (3) (see all 28)
    choriocarcinoma 33.6 5 8061055 (2)
    mesothelioma 33.3 4 20051956 (2), 19839924 (1)
    spina bifida 32.8 1 10234517 (1)
    cancer 32.5 22 10632363 (3), 18318652 (2), 8920973 (1), 8595169 (1) (see all 13)

    Genetic Association Database (GAD): FOLR1
    Human Genome Epidemiology (HuGE) Navigator: FOLR1 (24 documents)

    Export disorders for FOLR1 gene to outside databases

    Publications
    for FOLR1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FOLR1 gene, integrated from 9 sources (see all 250):
    (articles sorted by number of sources associating them with FOLR1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Folate-binding protein is a marker for ovarian cancer. (PubMed id 1717147)1, 2, 3, 9 Campbell I.G.... Trowsdale J. (1991)
    2. Polymorphisms and mutations of the folate receptor-alpha gene and risk of gastric cancer in a Chinese population. (PubMed id 15754024)1, 4, 9 Zhang G....Lu Y.Y. (2005)
    3. Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein. (PubMed id 1840502)1, 2, 9 Coney L.R.... Zurawski V.R. Jr. (1991)
    4. Folate receptor alpha defect causes cerebral folate t ransport deficiency: a treatable neurodegenerative disorder associated with dis turbed myelin metabolism. (PubMed id 19732866)1, 2, 9 Steinfeld R....GAortner J. (2009)
    5. Novel insertion and deletion mutations in the 5'-UTR of the folate receptor-alpha gene: an additional contributor to hyperhomocysteinemia? (PubMed id 14972645)1, 4, 9 Nilsson T.K. and Borjel A.K. (2004)
    6. Genomic organization of the gene and a related pseudogene for a human folate binding protein. (PubMed id 1581364)1, 2, 9 Sadasivan E.... Rothenberg S.P. (1992)
    7. Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol- anchored proteins released upon phospholipase D treatment. (PubMed id 16602701)1, 2 Elortza F.... Jensen O.N. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Proteomic analysis of glycosylphosphatidylinositol-anchored membrane proteins. (PubMed id 14517339)1, 2 Elortza F....Jensen O.N. (2003)
    10. Lack of association between mutations in the folate receptor-alpha gene and spina bifida. (PubMed id 9545095)1, 4 Barber R.C....Finnell R.H. (1998)

    External Searches for FOLR1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing FOLR1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2348 HGNC: 3791 AceView: FOLR1 Ensembl:ENSG00000110195 euGenes: HUgn2348
    ECgene: FOLR1 Kegg: 2348 H-InvDB: FOLR1

    Other Databases showing FOLR1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FOLR1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FOLR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FOLR1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for FOLR1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FOLR1 gene:
    Search GeneIP for patents involving FOLR1

    GeneCards and IP:
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