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FOLR1 Gene

protein-coding   GIFtS: 67
GCID: GC11P071900

Folate Receptor 1 (Adult)


(Previous symbol: FOLR)
  See FOLR1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Folate Receptor 1 (Adult)1 2     FR-alpha2 3
FOLR1 2 3     KB Cells FBP2 3
Adult Folate-Binding Protein2 3     Folate Binding Protein2
Folate Receptor, Adult2 3     Folate Receptor Alpha2
Ovarian Tumor-Associated Antigen MOv182 3     Folate Receptor 13
FBP2 3     

External Ids:    HGNC: 37911   Entrez Gene: 23482   Ensembl: ENSG000001101957   OMIM: 1364305   UniProtKB: P153283   

Export aliases for FOLR1 gene to outside databases

Previous GC identifers: GC11P074232 GC11P073440 GC11P072123 GC11P071626 GC11P071578 GC11P068193


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FOLR1 Gene:
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic
acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a
secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a
soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport
deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing,
multiple transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Oct
2009)

GeneCards Summary for FOLR1 Gene:
FOLR1 (folate receptor 1 (adult)) is a protein-coding gene. Diseases associated with FOLR1 include acute necrotizing encephalitis, and cerebral folate deficiency. GO annotations related to this gene include folic acid binding and receptor activity. An important paralog of this gene is FOLR3.

UniProtKB/Swiss-Prot: FOLR1_HUMAN, P15328
Function: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and
folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH.
Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces
its affinity for folates and mediates their release. Required for normal embryonic development and normal cell
proliferation

Gene Wiki entry for FOLR1 (Folate receptor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FOLR1 gene promoter:
         GR   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOLR1 promoter sequence
   Search Chromatin IP Primers for FOLR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOLR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.3-q14.1   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.3-q14.1

FOLR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOLR1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P071900:  view genomic region     (about GC identifiers)

Start:
71,900,602 bp from pter      End:
71,907,367 bp from pter
Size:
6,766 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FOLR1_HUMAN, P15328 (See protein sequence)
Recommended Name: Folate receptor alpha precursor  
Size: 257 amino acids; 29819 Da
4 PDB 3D structures from and Proteopedia for FOLR1:
4KM6 (3D)        4KM7 (3D)        4KMX (3D)        4LRH (3D)    
Secondary accessions: Q53EW2 Q6FGT8 Q6LC90 Q9UCT2

Explore the universe of human proteins at neXtProt for FOLR1: NX_P15328

Explore proteomics data for FOLR1 at MOPED

Post-translational modifications: 

  • The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by
    proteolysis catalyzed by a metalloprotease1
  • Glycosylation2 at Asn69, Asn161, Asn201

  • See FOLR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_000793.1  NP_057936.1  NP_057937.1  NP_057941.1  

    ENSEMBL proteins: 
     ENSP00000308137   ENSP00000377286   ENSP00000377284   ENSP00000377281  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR018143 Folate_rcpt-like
     IPR004269 Folate_rcpt

    Graphical View of Domain Structure for InterPro Entry P15328

    ProtoNet protein and cluster: P15328

    1 Blocks protein domain: IPB004269 Folate receptor

    UniProtKB/Swiss-Prot: FOLR1_HUMAN, P15328
    Similarity: Belongs to the folate receptor family


    Find genes that share domains with FOLR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOLR1_HUMAN, P15328
    Function: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and
    folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH.
    Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces
    its affinity for folates and mediates their release. Required for normal embryonic development and normal cell
    proliferation

         Genatlas biochemistry entry for FOLR1:
    folate receptor 1,adult

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS10633085
    GO:0005542folic acid binding NAS1840502
    GO:0008517folic acid transporter activity IMP8033114
         
    Find genes that share ontologies with FOLR1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FOLR1:
     Upregulation of Wnt/beta-caten 

         12 MGI mutant phenotypes (inferred from 1 allele(MGI details for Folr1):
     cellular  craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hearing/vestibular/ear  homeostasis/metabolism  mortality/aging  nervous system 
     tumorigenesis  vision/eye 

    Find genes that share phenotypes with FOLR1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Folr1tm1Fnn for FOLR1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FOLR1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FOLR1_HUMAN, P15328: Cell membrane; Lipid-anchor, GPI-anchor. Secreted (Probable). Cytoplasmic vesicle.
    Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Apical cell membrane (By similarity). Note=Endocytosed
    into cytoplasmic vesicles and then recycled to the cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular4
    endosome1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005768endosome IEA--
    GO:0005886plasma membrane NAS1840502
    GO:0005887integral component of plasma membrane TAS10633085
    GO:0005903brush border ----

    Find genes that share ontologies with FOLR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FOLR1 About    
    See pathways by source

    SuperPathContained pathways About
    1Methotrexate Pathway, Pharmacokinetics
    Methotrexate Pathway, Pharmacokinetics0.43
    2Endocytosis
    Endocytosis


    Find genes that share SuperPaths with FOLR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 PharmGKB Pathway for FOLR1
        Methotrexate Pathway, Pharmacokinetics

    1 Kegg Pathway  (Kegg details for FOLR1):
        Endocytosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FOLR1
    Interactions:

        Search GeneGlobe Interaction Network for FOLR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for FOLR1 (P153283 ENSP000003081374) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LYNP079483I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    CUL3ENSP000002644144STRING: ENSP00000264414
    IRAK3ENSP000002612334STRING: ENSP00000261233
    NCAPH2ENSP000004100884STRING: ENSP00000410088
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006898receptor-mediated endocytosis TAS9545095
    GO:0008219cell death IEA--
    GO:0015884folic acid transport IMP8033114
    GO:0046655folic acid metabolic process IEA--

    Find genes that share ontologies with FOLR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for FOLR1

    1 HMDB Compound for FOLR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Folic acidAcifolic (see all 37)59-30-3--

    1 DrugBank Compound for FOLR1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MethotrexateAmethopterin (see all 12)59-05-2transportersubstrate19093297

    Selected Novoseek inferred chemical compound relationships for FOLR1 gene (see all 25)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    folate 92.9 606 9791067 (7), 9426700 (6), 19056550 (5), 18776693 (5) (see all 99)
    5-methyltetrahydrofolate 87.3 19 15094208 (2), 9099956 (2), 9178098 (2), 14704289 (2) (see all 12)
    lometrexol 81.3 2 7508451 (2)
    methotrexate 63.3 41 7511899 (4), 7713875 (4), 17473184 (2), 2253202 (2) (see all 16)
    leucovorin 59 2 15585634 (1), 7579732 (1)
    tomudex 56.8 1 10699949 (1)
    probenecid 52.7 1 9178098 (1)
    homocysteine 47.3 6 11169018 (1), 15641086 (1), 16453285 (1), 19324355 (1)
    trimetrexate 45.7 3 12416030 (2)
    dihydrofolate 43.4 2 17534577 (1), 12416030 (1)



    Find genes that share compounds with FOLR1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FOLR1 gene (5 alternative transcripts): 
    NM_000802.3  NM_016724.2  NM_016725.2  NM_016729.2  NM_016730.1  

    Unigene Cluster for FOLR1:

    Folate receptor 1 (adult)
    Hs.73769  [show with all ESTs]
    Unigene Representative Sequence: X62753
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312293(uc001orz.2 uc001osa.2) ENST00000393681 ENST00000393679
    ENST00000393676(uc001osb.2 uc001osd.2)
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    Additional mRNA sequence: 

    AF000381.2 AK223527.1 BC002947.2 BT007158.1 CR542019.1 J05013.1 M25317.1 M28099.1 
    S73474.1 U78793.1 U78794.1 X62753.1 

    5 DOTS entries:

    DT.100770176  DT.447922  DT.95103787  DT.100770180  DT.100770179 

    Selected AceView cDNA sequences (see all 185):

    AA425789 NM_016730 BG433386 M28099 NM_016725 R24620 BQ027189 R26895 
    CR542019 S73474 CB242517 BQ017257 CR607460 NM_000802 BE901231 BG328933 
    J05013 M35069 BE744857 BC002947 AA669286 BI913499 NM_016724 AA488506 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FOLR1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:              -                                       
    SP2:              -     -                                 
    SP3:                                                      


    ECgene alternative splicing isoforms for FOLR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FOLR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCGGGCCTC
    FOLR1 Expression
    About this image


    FOLR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Definitive endoderm-like cells
     
     Placenta (Extraembryonic Tissues)
             Syncytiotrophoblast-like cells
     
     Kidney (Urinary System)
             Metanephros
     
     Neural Tube (Nervous System)
             Mesencephalic Floor Plate
     
     Brain (Nervous System)
             Midbrain tegmentum
    FOLR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FOLR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.73769

    UniProtKB/Swiss-Prot: FOLR1_HUMAN, P15328
    Tissue specificity: Primarily expressed in tissues of epithelial origin. Expression is increased in malignant
    tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FOLR1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Folr11 , 5 folate receptor 1 (adult)1, 5 81.4(n)1
    79.75(a)1
      7 (54.67 cM)5
    142751  NM_001252554.11  NP_001239483.11 
     1018583315 
    chicken
    (Gallus gallus)
    Aves FOLR11 folate receptor 1 (adult) 69.38(n)
    66.03(a)
      395638  NM_204834.1  NP_990165.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    73(a)
    1 → many
    AAWZ02038598(1643-1834)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC760482 hypothetical protein MGC76048 78.28(n)    BC062496.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1655021 zgc:165502 63.65(n)
    56.78(a)
      100073336  NM_001098772.1  NP_001092242.1 


    ENSEMBL Gene Tree for FOLR1 (if available)
    TreeFam Gene Tree for FOLR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FOLR1 gene
    FOLR32  FOLR42  FOLR22  
    3 SIMAP similar genes for FOLR1 using alignment to 1 protein entry:     FOLR1_HUMAN:
    FOLR2    FOLR4    FOLR3

    Find genes that share paralogs with FOLR1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for FOLR1
    PGOHUM00000242789


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FOLR1 (see all 210)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219184051,2
    Cpathogenic171770102(+) GGATCC/TAGCAG 8 Q * stg10--------
    rs1219184061,2
    Cpathogenic171770576(+) GCCTGA/CCAACC 8 * C stg10--------
    rs1874871711,2
    C--71762232(+) GTTTCC/GAACTC 2 -- us2k10--------
    rs1474208431,2
    C--71762265(+) TCTCGA/GCCTCC 2 -- us2k10--------
    rs1919988911,2
    --71762595(+) ACACGA/GCACTC 3 -- us2k10--------
    rs1848606641,2
    --71762673(+) GCGGCC/TCACAC 3 -- us2k10--------
    rs1892834021,2
    --71762800(+) CAGGCA/CTGGTG 3 -- us2k10--------
    rs1131076731,2
    C--71762870(+) GGAGGC/TGGAGG 3 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1808788891,2
    --71762973(+) AAAATG/TAATGT 3 -- us2k10--------
    rs1841259011,2
    --71763068(+) CATTCA/GTAGCT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for FOLR1 (71900602 - 71907367 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FOLR1: --
    Human Gene Mutation Database (HGMD): FOLR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FOLR1
    DNA2.0 Custom Variant and Variant Library Synthesis for FOLR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 136430   
    OMIM disorders: 613068  
    UniProtKB/Swiss-Prot: FOLR1_HUMAN, P15328
  • Neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]: A neurodegenerative
    disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with
    severe developmental regression, movement disturbances, epilepsy and leukodystrophy. Note=The disease is caused
    by mutations affecting the gene represented in this entry

  • 9 diseases for FOLR1:    
    About MalaCards
    acute necrotizing encephalitis    cerebral folate deficiency    pediatric osteosarcoma    anencephaly
    intraocular lymphoma    osteosarcoma    patent ductus arteriosus    spina bifida
    ovarian cancer

    2 diseases from the University of Copenhagen DISEASES database for FOLR1:
    Ovarian cancer     Acute necrotizing encephalitis

    Find genes that share disorders with FOLR1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FOLR1 gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    folate deficiency 71.9 4 9301457 (2), 8126512 (1), 15641086 (1)
    ovarian carcinoma 71.6 46 9426700 (4), 19454358 (4), 9218736 (4), 8242637 (3) (see all 20)
    ovarian cancer 56.9 27 19617914 (5), 19585555 (3), 1717147 (2), 16908932 (2) (see all 16)
    leukemia l1210 55.4 1 7579732 (1)
    anencephaly 43.2 1 17035141 (1)
    tumors 38.3 64 19585555 (5), 18222534 (5), 16453285 (4), 12874029 (3) (see all 28)
    choriocarcinoma 33.6 5 8061055 (2)
    mesothelioma 33.3 4 20051956 (2), 19839924 (1)
    spina bifida 32.8 1 10234517 (1)
    cancer 32.5 22 10632363 (3), 18318652 (2), 8920973 (1), 8595169 (1) (see all 13)

    Genetic Association Database (GAD): FOLR1
    Human Genome Epidemiology (HuGE) Navigator: FOLR1 (24 documents)

    Export disorders for FOLR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FOLR1 gene, integrated from 10 sources (see all 263):
    (articles sorted by number of sources associating them with FOLR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Folate-binding protein is a marker for ovarian cancer. (PubMed id 1717147)1, 2, 3, 9 Campbell I.G.... Trowsdale J. (Cancer Res. 1991)
    2. Interaction of genes from influx-metabolism-efflux pathway and their influence on methotrexate efficacy in rheumatoid arthritis patients among Indians. (PubMed id 19093297)1, 4, 7 Sharma S....B K T. (Pharmacogenet. Genomics 2008)
    3. Polymorphisms and mutations of the folate receptor-alpha gene and risk of gastric cancer in a Chinese population. (PubMed id 15754024)1, 4, 9 Zhang G....Lu Y.Y. (Int. J. Mol. Med. 2005)
    4. Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein. (PubMed id 1840502)1, 2, 9 Coney L.R.... Zurawski V.R. Jr. (Cancer Res. 1991)
    5. Mutations in exons 2 and 3 of the FOLR1 gene in demented and non-demented elderly subjects. (PubMed id 17912458)1, 4, 9 BAPttiger A.K....Nilsson T.K. (Int. J. Mol. Med. 2007)
    6. Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism. (PubMed id 19732866)1, 2, 9 Steinfeld R.... Gaertner J. (Am. J. Hum. Genet. 2009)
    7. Novel insertion and deletion mutations in the 5'-UTR of the folate receptor-alpha gene: an additional contributor to hyperhomocysteinemia? (PubMed id 14972645)1, 4, 9 Nilsson T.K. and BAPrjel A.K. (Clin. Biochem. 2004)
    8. Genomic organization of the gene and a related pseudogene for a human folate binding protein. (PubMed id 1581364)1, 2, 9 Sadasivan E.... Rothenberg S.P. (Biochim. Biophys. Acta 1992)
    9. Variations in folate pathway genes are associated with unexplained female infertility. (PubMed id 19324355)1, 4, 9 AltmAoe S....Nilsson T.K. (Fertil. Steril. 2010)
    10. Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions. (PubMed id 17035141)1, 4, 9 Boyles A.L....Speer M.C. (Environ. Health Perspect. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2348 HGNC: 3791 AceView: FOLR1 Ensembl:ENSG00000110195 euGenes: HUgn2348
    ECgene: FOLR1 Kegg: 2348 H-InvDB: FOLR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FOLR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FOLR1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FOLR1 gene:
    Search GeneIP for patents involving FOLR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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