FOLH1B Gene
protein-coding GIFtS: 43
GCID: GC11P089371
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folate hydrolase 1B(Previous name: folate hydrolase 2 )
(Previous symbols: FOLH2, FOLHP)
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Aliases
for FOLH1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Folate Hydrolase 1B1 2 | | GCP32 5 | | PSMAL1 2 3 5 | | PSM2 | | FOLH21 2 | | PSMA-LIKE2 | | FOLHP1 2 | | Folate Hydrolase Pseudogene2 | | GCPIII1 2 | | Glutamate Carboxypeptidase III2 | | Folate Hydrolase 21 2 | | N-Acetylated-Alpha-Linked-Acidic Dipeptidase2 | | Cell Growth-Inhibiting Gene 26 Protein2 3 | | Putative N-Acetylated-Alpha-Linked Acidic Dipeptidase2 | | Prostate-Specific Membrane Antigen-Like Protein2 3 | | EC 3.4.-.-3 | | Putative Folate Hydrolase 1B2 3 | | EC 3.4.17.218 | | NAALADase2 3 | | |
Export aliases for FOLH1B gene to outside databasesPrevious GC identifers: GC11P089034 GC11P089392 GC11P085629 |
Summaries
for FOLH1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FOH1B_HUMAN, Q9HBA9Function: Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity (Bysimilarity)Function: Exhibits a dipeptidyl-peptidase IV type activity (By similarity)
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Genomic Views
for FOLH1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FOLH1B gene promoter:
AML1a STAT5A NF-AT POU2F2C NF-AT4 NF-AT2 POU2F1 POU2F1a NF-AT3 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FOLH1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOLH1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q14.3 Ensembl cytogenetic band: 11q14.3 HGNC cytogenetic band: 11q14.3FOLH1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P089371: view genomic region
(about GC identifiers)
Start:
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89,371,683 bp from pter |
End:
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89,431,886 bp from pter |
Size:
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60,204 bases |
Orientation:
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plus strand |
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Proteins
for FOLH1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FOH1B_HUMAN, Q9HBA9 (See
protein sequence)Recommended Name: Putative N-acetylated-alpha-linked acidic dipeptidase Size: 442 amino acids; 50045 Da
Cofactor: Binds 2 zinc ions per subunit (By similarity). Required for NAALADase activity (By similarity)
Subcellular location: Cytoplasm (Probable)Explore the universe of human proteins at neXtProt for FOLH1B: NX_Q9HBA9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HBA9
4/5 DME Specific Peptides for FOLH1B (Q9HBA9) (see all 5)
FOLH1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_710163.1
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
FOLH1B for ontologies About GeneDecksing
FOLH1B Antibody Products:
Assay Products for FOLH1B: |
Protein
Domains /
Families
for FOLH1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FOLH1B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9HBA9ProtoNet protein and cluster: Q9HBA9 UniProtKB/Swiss-Prot: FOH1B_HUMAN, Q9HBA9Similarity: Belongs to the peptidase M28 family. M28B subfamily |
Function
for FOLH1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FOH1B_HUMAN, Q9HBA9Function: Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity (Bysimilarity)Function: Exhibits a dipeptidyl-peptidase IV type activity (By similarity)Enzyme Numbers (IUBMB): EC 3.4.-.-1 EC 3.4.17.212
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOLH1B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOLH1B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FOLH1B (NM_153696) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOLH1B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOLH1B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOLH1B |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008237 | metallopeptidase activity |
IEA | -- | | GO:0016805 | dipeptidase activity |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
FOLH1B for ontologies About GeneDecksing
|
Pathways & Interactions
for FOLH1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | One Carbon Metabolism | |
1  BioSystems Pathway for FOLH1B
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOLH1B
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
FOLH1B for ontologies About GeneDecksing
|
Drugs & Compounds
for FOLH1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
FOLH1B for compounds About GeneDecksing
 Browse Tocris compounds for FOLH1B
3 Novoseek chemical compound relationships for FOLH1B gene About this table
Search CenterWatch for drugs/clinical trials and news about FOLH1B / FOH1B
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Transcripts
for FOLH1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FOLH1B gene: NM_153696.2 Unigene Cluster for FOLH1B: Folate hydrolase 1B Hs.645352 [show with all ESTs]Unigene Representative Sequence: AF2617157 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000533785 ENST00000531315 ENST00000529567 ENST00000526379 ENST00000532352
ENST00000525540(uc001pda.3) ENST00000542857(uc001pcz.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOLH1B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOLH1B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FOLH1B (NM_153696) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOLH1B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOLH1B |
Additional cDNA sequence: AF027824.1 AF261715.1 AY544126.1 3 DOTS entries: DT.100758067 DT.443715 DT.100758065 6 AceView cDNA sequences: AF261715 AA435800 NM_153696 BG221564 BG202823 BG190737
GeneLoc Exon Structure
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Expression
for FOLH1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FOLH1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FOLH1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FOLH1B
SOURCE GeneReport for Unigene cluster: Hs.645352
UniProtKB/Swiss-Prot: FOH1B_HUMAN, Q9HBA9Tissue specificity: Kidney and liver. Not expressed in the prostate
SABiosciences Custom PCR Arrays for FOLH1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOLH1B
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FOLH1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOLH1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOLH1B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOLH1B |
Orthologs
for FOLH1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for FOLH1B (if available)
TreeFam Gene Tree for FOLH1B (if available) |
Paralogs
for FOLH1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FOLH1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FOLH1B (89371683 - 89431886 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FOLH1B
1 CNV: 6951 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for FOLH1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FOLH1B for disorders About GeneDecksing
OMIM gene information: 609020
OMIM disorders: --
7  diseases for FOLH1B: About MalaCardsprostatitis hearing loss renal cell carcinoma pancreatic carcinoma
breast cancer pancreatitis carcinoma
1 Novoseek disease relationship for FOLH1B gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
2 |
10469392 (2) |
Export disorders for FOLH1B gene to outside databases
|
Publications
for FOLH1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FOLH1B gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with FOLH1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Comparative analysis of prostate-specific membrane antigen (PSMA) versus a prostate-specific membrane antigen-like gene. (PubMed id 14716746)1, 2, 3, 9 O'Keefe D.S.... Heston W.D.W. (2004)
- Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene. (PubMed id 9838072)1, 3 O'Keefe D.S.... Heston W.D.W. (1998)
- Structural insight into the evolutionary and pharmaco logic homology of glutamate carboxypeptidases II and III. (PubMed id 19678840)1, 9 Hlouchova K....Lubkowski J. (2009)
- Molecular evolution of the transferrin receptor/glutamate carboxypeptidase II family. (PubMed id 17160644)1, 9 Lambert L.A. and Mitchell S.L. (2007)
- Glypican 3-expressing gastric carcinoma: distinct subgroup unifying hepatoid, clear-cell, and alpha-fetoprotein-producing gastric carcinomas. (PubMed id 19243386)1 Ushiku T....Fukayama M. (2009)
- Detailed genetic mapping around a putative prostate-specific membrane antigen locus on human chromosome 11p11.2. (PubMed id 9691167)1 Maraj B.H....Markham A.F. (1998)
- Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen. (PubMed id 8417812)1 Israeli R.S.... Heston W.D.W. (1993)
- Biochemical characterization of human glutamate carboxypeptidase III. (PubMed id 17241121)9 Hlouchova K....Konvalinka J. (2007)
- Localization of prostate-specific antigen-like immunoreactivity in human salivary gland and salivary gland tumors. (PubMed id 10469392)9 Tazawa K....Tsutsumi Y. (1999)
- A prostate-specific antigen-like protein associated with renal cell carcinoma in women. (PubMed id 9815828)9 Clements J....Nicol D. (1997)
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External Searches for FOLH1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing FOLH1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FOLH1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FOLH1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FOLH1B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FOLH1B gene:
Search GeneIP for patents involving FOLH1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FOLH1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FOLH1B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOLH1B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOLH1B | | | OriGene Protein Over-expression Lysate for FOLH1B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FOLH1B | | OriGene 3'-UTR Clone for FOLH1B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOLH1B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOLH1B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FOLH1B | | OriGene Custom Protein Services for FOLH1B | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FOLH1B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOLH1B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOLH1B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOLH1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOLH1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOLH1B |
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 |  |  |  | |
| | | | Search Tocris compounds for FOLH1B |
| |  |  |  |  | | | | |
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 | | | FOLH1B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOLH1B |
|  |  |  | | | | ThermoFisher Antibody for FOLH1B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOLH1B |
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