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FOLH1B Gene

protein-coding   GIFtS: 43
GCID: GC11P089371

Folate Hydrolase 1B

(Previous name: folate hydrolase 2)
(Previous symbols: FOLH2, FOLHP)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Folate Hydrolase 1B1 2     GCP32 5
Cell Growth-Inhibiting Gene 26 Protein1 2 3     Prostate Specific Membrane Antigen Like Protein1
PSMAL2 3 5     GCPIII2
FOLH21 2     PSM2
FOLHP1 2     PSMA-LIKE2
Folate Hydrolase 21 2     Folate Hydrolase Pseudogene2
Glutamate Carboxypeptidase III1 2     N-Acetylated-Alpha-Linked-Acidic Dipeptidase2
Prostate-Specific Membrane Antigen-Like Protein2 3     Putative N-Acetylated-Alpha-Linked Acidic Dipeptidase2
Putative Folate Hydrolase 1B2 3     EC 3.4.-.-3
NAALADase2 3     EC 3.4.17.218

External Ids:    HGNC: 136361   Entrez Gene: 2195952   Ensembl: ENSG000001346127   OMIM: 6090205   UniProtKB: Q9HBA93   

Export aliases for FOLH1B gene to outside databases

Previous GC identifers: GC11P089034 GC11P089392 GC11P085629


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FOLH1B Gene:
FOLH1B (folate hydrolase 1B) is a protein-coding gene. Diseases associated with FOLH1B include prostatitis, and renal cell carcinoma. GO annotations related to this gene include metallopeptidase activity and dipeptidase activity.

UniProtKB/Swiss-Prot: FOH1B_HUMAN, Q9HBA9
Function: Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity (By
similarity)
Function: Exhibits a dipeptidyl-peptidase IV type activity (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FOLH1B gene promoter:
         AML1a   STAT5A   NF-AT   POU2F2C   NF-AT4   NF-AT2   POU2F1   POU2F1a   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOLH1B promoter sequence
   Search Chromatin IP Primers for FOLH1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FOLH1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.3   Ensembl cytogenetic band:  11q14.3   HGNC cytogenetic band: 11q14.3

FOLH1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOLH1B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P089371:  view genomic region     (about GC identifiers)

Start:
89,371,683 bp from pter      End:
89,431,886 bp from pter
Size:
60,204 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FOH1B_HUMAN, Q9HBA9 (See protein sequence)
Recommended Name: Putative N-acetylated-alpha-linked acidic dipeptidase  
Size: 442 amino acids; 50045 Da
Cofactor: Binds 2 zinc ions per subunit (By similarity). Required for NAALADase activity (By similarity)

Explore the universe of human proteins at neXtProt for FOLH1B: NX_Q9HBA9

Explore proteomics data for FOLH1B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FOLH1B (Q9HBA9) (see all 5)
     SFDSLFSAV  LERAFIDPLGLP  EPDRYVILGGHRD  IEGNYTLRVDCTPL 


    See FOLH1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_710163.1  

    FOLH1B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Folate hydrolase 1B
    Metallocarboxypeptidases

    2 InterPro protein domains:
     IPR007365 TFR-like_dimer_dom
     IPR007484 Peptidase_M28

    Graphical View of Domain Structure for InterPro Entry Q9HBA9

    ProtoNet protein and cluster: Q9HBA9

    UniProtKB/Swiss-Prot: FOH1B_HUMAN, Q9HBA9
    Similarity: Belongs to the peptidase M28 family. M28B subfamily


    FOLH1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOH1B_HUMAN, Q9HBA9
    Function: Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity (By
    similarity)
    Function: Exhibits a dipeptidyl-peptidase IV type activity (By similarity)

         Enzyme Numbers (IUBMB): EC 3.4.-.-1 EC 3.4.17.212

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008237metallopeptidase activity IEA--
    GO:0016805dipeptidase activity IEA--
    GO:0046872metal ion binding IEA--
         
    FOLH1B for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FOLH1B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FOLH1B
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    miRNA
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FOH1B_HUMAN, Q9HBA9: Cytoplasm (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    FOLH1B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FOLH1B About    
    See pathways by source

    SuperPathContained pathways About
    1One carbon pool by folate
    One Carbon Metabolism0.53


    1 BioSystems Pathway for FOLH1B
        One Carbon Metabolism


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FOLH1B
    Interactions:

        Search GeneGlobe Interaction Network for FOLH1B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FOLH1B (FOH1B)

    3 Novoseek inferred chemical compound relationships for FOLH1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    naag 80.6 1 11525768 (1)
    n-acetyl-aspartyl-glutamate 78.8 1 11525768 (1)
    glutamate 41 8 17241121 (2), 11525768 (1), 15086519 (1), 19678840 (1) (see all 5)



    FOLH1B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FOLH1B gene: 
    NM_153696.2  

    Unigene Cluster for FOLH1B:

    Folate hydrolase 1B
    Hs.645352  [show with all ESTs]
    Unigene Representative Sequence: AF261715
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533785 ENST00000531315 ENST00000529567 ENST00000526379 ENST00000532352
    ENST00000525540(uc001pda.3) ENST00000542857(uc001pcz.3)
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidFOLH1B 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat FOLH1B
      QuantiFast Probe-based Assays in human, mouse, rat FOLH1B

    Additional mRNA sequence: 

    AF027824.1 AF261715.1 AY544126.1 

    3 DOTS entries:

    DT.100758067  DT.443715  DT.100758065 

    6 AceView cDNA sequences:

    AF261715 AA435800 NM_153696 BG202823 BG221564 BG190737 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FOLH1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FOLH1B Expression
    About this image

    FOLH1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FOLH1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.645352

    UniProtKB/Swiss-Prot: FOH1B_HUMAN, Q9HBA9
    Tissue specificity: Kidney and liver. Not expressed in the prostate

        Custom PCR Arrays for FOLH1B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOLH1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for FOLH1B (if available)
    TreeFam Gene Tree for FOLH1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FOLH1B gene
    4 SIMAP similar genes for FOLH1B using alignment to 1 protein entry:     FOH1B_HUMAN:
    FOLH1    NAALAD2    NAALADL1    TFR2

    FOLH1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FOLH1B (see all 1001)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1888741321,2
    --89390494(+) CTGAAC/TTGAAA 1 -- us2k10--------
    rs108303281,2
    C,A--89390522(+) TAATTA/GTGGAG 1 -- us2k1 tfbs30--------
    rs47532331,2
    C,F--89390530(+) GAGTGT/CTCTCT 1 -- us2k14Minor allele frequency- C:0.25NA WA 8
    rs108303291,2
    C,F,A,H--89390612(+) GGATAA/GCCTTG 1 -- us2k17Minor allele frequency- G:0.20NS EA NA WA 660
    rs1383165061,2
    --89390664(+) TCCTAC/TGTTAG 1 -- us2k10--------
    rs1922045801,2
    --89390699(+) CCTCAC/TATCAA 1 -- us2k10--------
    rs3718049631,2
    C--89390768(+) CTACAG/TCTGAG 1 -- us2k10--------
    rs1855363931,2
    --89390888(+) CAGCAC/TAAATA 1 -- us2k10--------
    rs1907858911,2
    --89390919(+) TTCTGC/TGGGGG 1 -- us2k10--------
    rs122744981,2
    C--89390938(+) CAATAC/TACAAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FOLH1B (89371683 - 89431886 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FOLH1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv527380CNV Loss19592680
    dgv1254n71CNV Loss21882294
    nsv898096CNV Loss21882294
    dgv1255n71CNV Gain21882294
    nsv898094CNV Gain21882294
    nsv468785CNV Gain19166990
    esv32702CNV Gain+Loss17666407

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FOLH1B
    DNA2.0 Custom Variant and Variant Library Synthesis for FOLH1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609020    OMIM disorders: --

    4 diseases for FOLH1B:    
    About MalaCards
    prostatitis    renal cell carcinoma    pancreatitis    breast cancer


    FOLH1B for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for FOLH1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 10469392 (2)


    Export disorders for FOLH1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FOLH1B gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with FOLH1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Comparative analysis of prostate-specific membrane antigen (PSMA) versus a prostate-specific membrane antigen-like gene. (PubMed id 14716746)1, 2, 3, 9 O'Keefe D.S.... Heston W.D.W. (Prostate 2004)
    2. Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene. (PubMed id 9838072)1, 3 O'Keefe D.S.... Heston W.D.W. (Biochim. Biophys. Acta 1998)
    3. Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III. (PubMed id 19678840)1, 9 Hlouchova K.... Lubkowski J. (FEBS J. 2009)
    4. Molecular evolution of the transferrin receptor/glutamate carboxypeptidase II family. (PubMed id 17160644)1, 9 Lambert L.A. and Mitchell S.L. (J. Mol. Evol. 2007)
    5. Glypican 3-expressing gastric carcinoma: distinct subgroup unifying hepatoid, clear-cell, and alpha-fetoprotein-producing gastric carcinomas. (PubMed id 19243386)1 Ushiku T....Fukayama M. (Cancer Sci. 2009)
    6. Detailed genetic mapping around a putative prostate-specific membrane antigen locus on human chromosome 11p11.2. (PubMed id 9691167)1 Maraj B.H....Markham A.F. (Cytogenet. Cell Genet. 1998)
    7. Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen. (PubMed id 8417812)1 Israeli R.S.... Heston W.D.W. (Cancer Res. 1993)
    8. Biochemical characterization of human glutamate carboxypeptidase III. (PubMed id 17241121)9 HlouchovA! K....Konvalinka J. (J. Neurochem. 2007)
    9. Localization of prostate-specific antigen-like immunoreactivity in human salivary gland and salivary gland tumors. (PubMed id 10469392)9 Tazawa K....Tsutsumi Y. (Pathol. Int. 1999)
    10. A prostate-specific antigen-like protein associated with renal cell carcinoma in women. (PubMed id 9815828)9 Clements J....Nicol D. (Clin. Cancer Res. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 219595 HGNC: 13636 AceView: FOLH2 Ensembl:ENSG00000134612 euGenes: HUgn219595
    ECgene: FOLH1B H-InvDB: FOLH1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FOLH1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FOLH1B gene:
    Search GeneIP for patents involving FOLH1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FOLH1B  
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     Search Tocris compounds for FOLH1B (FOH1B)
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Biologicals
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     Browse ESI BIO Cell Lines and PureStem Progenitors for FOLH1B
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOLH1B
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FOLH1B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FOLH1B
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     LSBio Antibodies in human, mouse, rat for FOLH1B
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     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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