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Aliases for FOLH1B Gene

Aliases for FOLH1B Gene

  • Folate Hydrolase 1B 2 3
  • Cell Growth-Inhibiting Gene 26 Protein 2 3 4
  • Prostate-Specific Membrane Antigen-Like Protein 3 4
  • Glutamate Carboxypeptidase III 2 3
  • Putative Folate Hydrolase 1B 3 4
  • Folate Hydrolase 2 2 3
  • NAALADase 3 4
  • PSMAL 3 4
  • Prostate Specific Membrane Antigen Like Protein 2
  • N-Acetylated-Alpha-Linked-Acidic Dipeptidase 3
  • Folate Hydrolase Pseudogene 3
  • EC 3.4.17.21 63
  • EC 3.4.-.- 4
  • PSMA-LIKE 3
  • GCPIII 3
  • FOLH2 3
  • FOLHP 3
  • GCP3 3
  • PSM 3

External Ids for FOLH1B Gene

Previous HGNC Symbols for FOLH1B Gene

  • FOLH2
  • FOLHP

Previous GeneCards Identifiers for FOLH1B Gene

  • GC11P089034
  • GC11P089392
  • GC11P085629
  • GC11P089371

Summaries for FOLH1B Gene

GeneCards Summary for FOLH1B Gene

FOLH1B (Folate Hydrolase 1B) is a Protein Coding gene. Among its related pathways are Metabolism and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include metallopeptidase activity and dipeptidase activity.

UniProtKB/Swiss-Prot for FOLH1B Gene

  • Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity.

  • Exhibits a dipeptidyl-peptidase IV type activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOLH1B Gene

Genomics for FOLH1B Gene

Regulatory Elements for FOLH1B Gene

Genomic Location for FOLH1B Gene

Chromosome:
11
Start:
89,637,520 bp from pter
End:
89,698,718 bp from pter
Size:
61,199 bases
Orientation:
Plus strand

Genomic View for FOLH1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for FOLH1B Gene

Proteins for FOLH1B Gene

  • Protein details for FOLH1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBA9-FOH1B_HUMAN
    Recommended name:
    Putative N-acetylated-alpha-linked acidic dipeptidase
    Protein Accession:
    Q9HBA9

    Protein attributes for FOLH1B Gene

    Size:
    442 amino acids
    Molecular mass:
    50045 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit. Required for NAALADase activity.;
    Quaternary structure:
    No Data Available

neXtProt entry for FOLH1B Gene

Proteomics data for FOLH1B Gene at MOPED

Post-translational modifications for FOLH1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOLH1B Gene

REFSEQ proteins:

Domains & Families for FOLH1B Gene

Gene Families for FOLH1B Gene

Protein Domains for FOLH1B Gene

Suggested Antigen Peptide Sequences for FOLH1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBA9

UniProtKB/Swiss-Prot:

FOH1B_HUMAN :
  • Belongs to the peptidase M28 family. M28B subfamily.
Family:
  • Belongs to the peptidase M28 family. M28B subfamily.
genes like me logo Genes that share domains with FOLH1B: view

Function for FOLH1B Gene

Molecular function for FOLH1B Gene

UniProtKB/Swiss-Prot Function:
Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity.
UniProtKB/Swiss-Prot Function:
Exhibits a dipeptidyl-peptidase IV type activity.

Enzyme Numbers (IUBMB) for FOLH1B Gene

Gene Ontology (GO) - Molecular Function for FOLH1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004181 metallocarboxypeptidase activity IDA 17241121
GO:0016805 dipeptidase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FOLH1B: view

Phenotypes for FOLH1B Gene

GenomeRNAi human phenotypes for FOLH1B:
genes like me logo Genes that share phenotypes with FOLH1B: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOLH1B

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FOLH1B Gene

Localization for FOLH1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOLH1B Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for FOLH1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with FOLH1B: view

No data available for Subcellular locations from COMPARTMENTS for FOLH1B Gene

Pathways & Interactions for FOLH1B Gene

genes like me logo Genes that share pathways with FOLH1B: view

Pathways by source for FOLH1B Gene

Interacting Proteins for FOLH1B Gene

Gene Ontology (GO) - Biological Process for FOLH1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0008652 cellular amino acid biosynthetic process TAS --
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0035609 C-terminal protein deglutamylation IDA 17241121
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with FOLH1B: view

No data available for SIGNOR curated interactions for FOLH1B Gene

Drugs & Compounds for FOLH1B Gene

(1) Drugs for FOLH1B Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NAAG Pharma Full agonist, Agonist 0

(2) Additional Compounds for FOLH1B Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
glutamate
N-Acetyl-aspartyl-glutamate
genes like me logo Genes that share compounds with FOLH1B: view

Transcripts for FOLH1B Gene

mRNA/cDNA for FOLH1B Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOLH1B Gene

Folate hydrolase 1B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOLH1B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOLH1B Gene

No ASD Table

Relevant External Links for FOLH1B Gene

GeneLoc Exon Structure for
FOLH1B
ECgene alternative splicing isoforms for
FOLH1B

Expression for FOLH1B Gene

mRNA expression in normal human tissues for FOLH1B Gene

mRNA differential expression in normal tissues according to GTEx for FOLH1B Gene

This gene is overexpressed in Liver (x12.4), Brain - Spinal cord (cervical c-1) (x6.8), Kidney - Cortex (x4.8), Prostate (x4.6), and Brain - Substantia nigra (x4.0).

Protein differential expression in normal tissues from HIPED for FOLH1B Gene

This gene is overexpressed in Spinal cord (58.9) and Brain (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FOLH1B Gene



SOURCE GeneReport for Unigene cluster for FOLH1B Gene Hs.645352

mRNA Expression by UniProt/SwissProt for FOLH1B Gene

Q9HBA9-FOH1B_HUMAN
Tissue specificity: Kidney and liver. Not expressed in the prostate.
genes like me logo Genes that share expression patterns with FOLH1B: view

Protein tissue co-expression partners for FOLH1B Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FOLH1B Gene

Orthologs for FOLH1B Gene

Evolution for FOLH1B Gene

ENSEMBL:
Gene Tree for FOLH1B (if available)
TreeFam:
Gene Tree for FOLH1B (if available)

No data available for Orthologs for FOLH1B Gene

Paralogs for FOLH1B Gene

(4) SIMAP similar genes for FOLH1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOLH1B: view

No data available for Paralogs for FOLH1B Gene

Variants for FOLH1B Gene

Sequence variations from dbSNP and Humsavar for FOLH1B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs931394 -- 89,664,651(-) TTTTT(A/G)AAACT intron-variant
rs1122483 -- 89,645,962(+) GTTGA(A/G)CTCTG intron-variant
rs1486314 -- 89,643,135(-) ATGAA(A/T)TTACA intron-variant
rs1817714 -- 89,699,182(+) TGAAC(C/T)TAATA downstream-variant-500B
rs1843630 -- 89,643,011(-) tcatt(C/G)tgttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FOLH1B Gene

Variant ID Type Subtype PubMed ID
esv32702 CNV Gain+Loss 17666407
nsv468785 CNV Gain 19166990
dgv1254n71 CNV Loss 21882294
nsv898094 CNV Gain 21882294
nsv898096 CNV Loss 21882294
dgv1255n71 CNV Gain 21882294
nsv527380 CNV Loss 19592680

Relevant External Links for FOLH1B Gene

HapMap Linkage Disequilibrium report
FOLH1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FOLH1B Gene

Disorders for FOLH1B Gene

Relevant External Links for FOLH1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOLH1B
genes like me logo Genes that share disorders with FOLH1B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOLH1B Gene

Publications for FOLH1B Gene

  1. Comparative analysis of prostate-specific membrane antigen (PSMA) versus a prostate-specific membrane antigen-like gene. (PMID: 14716746) O'Keefe D.S. … Heston W.D.W. (Prostate 2004) 2 23 67
  2. Genetic determinants of hearing loss associated with vestibular schwannomas. (PMID: 19546833) Stankovic K.M. … Stemmer-Rachamimov A.O. (Otol. Neurotol. 2009) 23 67
  3. Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III. (PMID: 19678840) Hlouchova K. … Lubkowski J. (FEBS J. 2009) 23 67
  4. Molecular evolution of the transferrin receptor/glutamate carboxypeptidase II family. (PMID: 17160644) Lambert L.A. … Mitchell S.L. (J. Mol. Evol. 2007) 23 67
  5. Biochemical characterization of human glutamate carboxypeptidase III. (PMID: 17241121) HlouchovA! K. … Konvalinka J. (J. Neurochem. 2007) 23 67

Products for FOLH1B Gene

Sources for FOLH1B Gene

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