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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FOLH1 Gene

protein-coding   GIFtS: 71
GCID: GC11M049168

Folate Hydrolase (Prostate-Specific Membrane Antigen) 1


(Previous symbol: FOLH)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Folate Hydrolase (Prostate-Specific Membrane Antigen) 11 2     NAALAD12 3
FOLH1 2 3 5     mGCP2 3
Glutamate Carboxypeptidase II1 2 3     N-Acetylated-Alpha-Linked Acidic Dipeptidase I2 3
PSM2 3 5     NAALADase I2 3
PSMA2 3 5     EC 3.4.17.213 8
Glutamate Carboxylase II1 2     GCP22
Cell Growth-Inhibiting Gene 27 Protein2 3     NAALAdase2
Folylpoly-Gamma-Glutamate Carboxypeptidase2 3     Glutamate Carboxypeptidase 22
Membrane Glutamate Carboxypeptidase2 3     N-Acetylated Alpha-Linked Acidic Dipeptidase 12
Pteroylpoly-Gamma-Glutamate Carboxypeptidase2 3     Prostate Specific Membrane Antigen Variant F2
FGCP2 3     Folate Hydrolase 13
GCPII2 3     Prostate-Specific Membrane Antigen3

External Ids:    HGNC: 37881   Entrez Gene: 23462   Ensembl: ENSG000000862057   OMIM: 6009345   UniProtKB: Q046093   

Export aliases for FOLH1 gene to outside databases

Previous GC identifers: GC11M051274 GC11M050361 GC11M049199 GC11M049132 GC11M049124 GC11M048888


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FOLH1 Gene:
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as
a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the
neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central
and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal
absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia.
Expression of this protein in the brain may be involved in a number of pathological conditions associated with
glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an
effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event
of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several
different isoforms. (provided by RefSeq, Jul 2010)

GeneCards Summary for FOLH1 Gene: 
FOLH1 (folate hydrolase (prostate-specific membrane antigen) 1) is a protein-coding gene. Diseases associated with FOLH1 include prostatitis, and hyperhomocysteinemia, and among its related super-pathways are One carbon pool by folate and GPCRs, Class C Metabotropic glutamate, pheromone. GO annotations related to this gene include peptidase activity and carboxypeptidase activity. An important paralog of this gene is NAALADL1.

UniProtKB/Swiss-Prot: FOLH1_HUMAN, Q04609
Function: Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a
preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain,
modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate
(NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically
irrelevant. Involved in prostate tumor progression
Function: Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC

Gene Wiki entry for FOLH1 (Glutamate carboxypeptidase II) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FOLH1 gene promoter:
         AP-2alpha isoform 3   AML1a   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFOLH1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FOLH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOLH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.12   HGNC cytogenetic band: 11p11.2

FOLH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FOLH1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M049168:  view genomic region     (about GC identifiers)

Start:
49,168,187 bp from pter      End:
49,230,222 bp from pter
Size:
62,036 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FOLH1_HUMAN, Q04609 (See protein sequence)
Recommended Name: Glutamate carboxypeptidase 2  
Size: 750 amino acids; 84331 Da
Cofactor: Binds 2 zinc ions per subunit. Required for NAALADase activity
Subunit: Homodimer
Subcellular location: Cell membrane; Single-pass type II membrane protein
Subcellular location: Isoform PSMA': Cytoplasm
Miscellaneous: PSMA is used as a diagnostic and prognostic indicator of prostate cancer, and as a possible marker
for various neurological disorders such as schizophrenia, Alzheimer disease and Huntington disease
Sequence caution: Sequence=AAF31167.1; Type=Erroneous gene model prediction;
6/29 PDB 3D structures from and Proteopedia for FOLH1 (see all 29):
1Z8L (3D)        2C6C (3D)        2C6G (3D)        2C6P (3D)        2CIJ (3D)        2JBJ (3D)    
Secondary accessions: A4UU12 A9CB79 B7Z312 B7Z343 D3DQS5 E9PDX8 O43748 Q16305 Q541A4 Q8TAY3
Q9NP15 Q9NYE2 Q9P1P8
Alternative splicing: 8 isoforms:  Q04609-1   Q04609-3   Q04609-4   Q04609-6   Q04609-7   Q04609-8   Q04609-9   Q04609-10   
(No experimental confirmation available. Incomplete sequence)

Explore the universe of human proteins at neXtProt for FOLH1: NX_Q04609

Explore proteomics data for FOLH1 at MOPED 

Post-translational modifications:

  • UniProtKB: The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis
  • UniProtKB: The N-terminus is blocked
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q04609

  • 4/6 DME Specific Peptides for FOLH1 (Q04609) (see all 6)
     SFDSLFSAV  ILYSDPADYF  LERAFIDPLGLP  EPDRYVILGGHRD 

    FOLH1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FOLH1 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001014986.1  NP_001180400.1  NP_001180401.1  NP_001180402.1  NP_004467.1  

    ENSEMBL proteins: 
     ENSP00000256999   ENSP00000349129   ENSP00000434928   ENSP00000344131   ENSP00000431463  
     ENSP00000436569   ENSP00000431577   ENSP00000431263   ENSP00000344086  

    Human Recombinant Protein Products for FOLH1: 
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    Novus Biologicals FOLH1 Lysates
    Sino Biological Recombinant Protein for FOLH1
    Sino Biological Cell Lysate for FOLH1 
    ProSpec Recombinant Protein for FOLH1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005887integral to plasma membrane IEA--
    GO:0016020membrane NAS9375657
    GO:0016021integral to membrane ----

    FOLH1 for ontologies           About GeneDecksing



    FOLH1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for FOLH1 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Folate hydrolase (prostate-specific membrane antigen) 1 
    Metallocarboxypeptidases

    3 InterPro protein domains:
     IPR007365 TFR-like_dimer_dom
     IPR007484 Peptidase_M28
     IPR003137 Protease-assoc_domain

    Graphical View of Domain Structure for InterPro Entry Q04609

    ProtoNet protein and cluster: Q04609

    3 Blocks protein domains:
    IPB003137 Protease-associated PA
    IPB007365 Transferrin receptor-like dimerisation domain
    IPB007484 Peptidase family M28


    UniProtKB/Swiss-Prot: FOLH1_HUMAN, Q04609
    Domain: The NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the
    C-terminal
    Similarity: Belongs to the peptidase M28 family. M28B subfamily


    FOLH1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOLH1_HUMAN, Q04609
    Function: Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a
    preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain,
    modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate
    (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically
    irrelevant. Involved in prostate tumor progression
    Function: Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC
    Catalytic activity: Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or
    folylpoly-gamma-glutamates
    Enzyme regulation: The NAALADase activity is inhibited by beta-NAAG, quisqualic acid, 2-(phosphonomethyl)
    pentanedioic acid (PMPA) and EDTA. Activated by cobalt
    Biophysicochemical properties: pH dependence: Stable at pH greater than 6.5;
    Induction: In the prostate, up-regulated in response to androgen deprivation

         Enzyme Number (IUBMB): EC 3.4.17.211 2

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004180carboxypeptidase activity IEA--
    GO:0008233peptidase activity NAS9375657
    GO:0008237metallopeptidase activity IEA--
    GO:0016805dipeptidase activity IEA--
    GO:0046872metal ion binding IEA--
         
    FOLH1 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Folh1):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  nervous system 

    FOLH1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Folh1tm1Nle for FOLH1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FOLH1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FOLH1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FOLH1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FOLH1 

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOLH1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FOLH1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1One Carbon Metabolism
    One Carbon Metabolism0.53
    2Synaptic Neurotransmission: Glutamatergic Excitation
    Synaptic Neurotransmission: Glutamatergic Excitation0.33
    3Vitamin digestion and absorption
    Vitamin digestion and absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for FOLH1
        Synaptic Neurotransmission: Glutamatergic Excitation


    1 BioSystems Pathway for FOLH1
        One Carbon Metabolism



    1         Kegg Pathway  (Kegg details for FOLH1):
        Vitamin digestion and absorption


    FOLH1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FOLH1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for FOLH1 (Q046092, 3 ENSP000002569994) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMEP084733, ENSP000003536794I2D: score=2 STRING: ENSP00000353679
    MTAPENSP000003695194STRING: ENSP00000369519
    RPS3ENSP000002785724STRING: ENSP00000278572
    --P310162MINT-8105797
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis NAS9375657
    GO:0006760folic acid-containing compound metabolic process IEA--

    FOLH1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FOLH1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for FOLH1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PMPA (NAALADase inhibitor)GCP II inhibitor[173039-10-6]

    2 HMDB Compounds for FOLH1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CobaltCo (see all 6)7440-48-4--
    L-Glutamic acid(2S)-2-Aminopentanedioate (see all 49)56-86-0--

    4 DrugBank Compounds for FOLH1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    CapromabCapromab pendetide (see all 3)145464-28-4targetother/unknown11752352 9508077 11016653 9792131 15882479
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--15837926 15336276 17139284 17016423 11916141
    (2S)-2-{[HYDROXY(4-IODOBENZYL)PHOSPHORYL]METHYL}PENTANEDIOIC ACID-- --target--10592235
    N-({(1R)-1-carboxy-2-[(4-fluorobenzyl)sulfanyl]ethyl}carbamoyl)-L-glutamic acid-- --target--10592235

    10/41 Novoseek inferred chemical compound relationships for FOLH1 gene (see all 41)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    naag 93.7 109 7575102 (6), 10991955 (5), 12213057 (4), 12358725 (4) (see all 41)
    n-acetyl-aspartyl-glutamate 93.3 48 17150306 (2), 10861758 (2), 9622670 (2), 11102961 (2) (see all 27)
    prostascint 90.3 18 9397201 (3), 15882479 (1), 15225091 (1), 9792131 (1) (see all 10)
    pmsa 72.1 3 11432343 (1), 11170145 (1), 12750292 (1)
    glutamate 65.8 277 7575102 (6), 11905994 (5), 12826236 (5), 12213057 (4) (see all 93)
    l-serine o-sulfate 65.4 2 17567119 (1)
    folate 64.6 150 19830782 (7), 18974153 (5), 11210180 (3), 12949938 (3) (see all 39)
    pmpa 64.6 5 19706750 (2), 12213057 (1)
    n-acetylaspartate 62.3 36 7575102 (2), 9376025 (2), 12826236 (2), 9882712 (1) (see all 16)
    lutetium 53.9 1 16729907 (1)

    Search CenterWatch for drugs/clinical trials and news about FOLH1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FOLH1 gene (5 alternative transcripts): 
    NM_001014986.1  NM_001193471.1  NM_001193472.1  NM_001193473.1  NM_004476.1  

    Unigene Cluster for FOLH1:

    Folate hydrolase (prostate-specific membrane antigen) 1
    Hs.654487  [show with all ESTs]
    Unigene Representative Sequence: NM_001193471
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000458311(uc001ngx.3) ENST00000256999(uc001ngy.3 uc001ngz.3 uc009yma.3)
    ENST00000356696 ENST00000525826 ENST00000340334(uc009yly.3 uc009ylz.3 uc001nha.3)
    ENST00000533034 ENST00000532018 ENST00000525629 ENST00000526226 ENST00000529646
    ENST00000533510 ENST00000529117 ENST00000529648 ENST00000343844

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    Additional mRNA sequence: 

    AB231784.1 AF176574.1 AF254357.1 AF254358.1 AJ007318.1 AK295368.1 AK295470.1 AK300532.1 
    AK312366.1 AY101595.1 BC025672.1 BC108719.1 DQ088979.1 EF488811.2 EF488812.1 M99487.1 
    S76978.1 

    12 DOTS entries:

    DT.443715  DT.100758065  DT.120728868  DT.120698266  DT.100758067  DT.120728886  DT.120728878  DT.120728891 
    DT.120728892  DT.40106202  DT.87078118  DT.91946447 

    24/89 AceView cDNA sequences (see all 89):

    BX281833 CA489536 CR619031 AF254357 AW000926 AY101595 NM_004476 AJ007318 
    CB216928 BX643466 AF176574 BC025672 CF146716 BF438644 CF147222 AI478207 
    M99487 AI768508 BF940223 BQ948549 CA487483 AI356718 AI050871 BQ711571 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FOLH1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9
    SP1:                                -     -     -     -     -                             -                     
    SP2:                                -     -     -           -                                                   
    SP3:                                -     -     -     -     -           -     -           -                     
    SP4:                                -     -     -     -                                                         
    SP5:                                -                 -     -                                                   


    ECgene alternative splicing isoforms for FOLH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FOLH1 expression in normal human tissues (normalized intensities)      FOLH1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATCTATGC
    FOLH1 Expression
    About this image


    FOLH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Prostate (Endocrine System)
             prostate ; glandular cells   
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme
     
     Spinal Cord (Nervous System)
             Superior Cervical Ganglion   
     
     Kidney (Urinary System)

    See FOLH1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FOLH1

    SOURCE GeneReport for Unigene cluster: Hs.654487

    UniProtKB/Swiss-Prot: FOLH1_HUMAN, Q04609
    Tissue specificity: Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary,
    fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein
    level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the
    capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the
    brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform
    PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate
    tumors. Isoform PSMA-2 is also found in normal prostate as well as in brain and liver. Isoform PSMA-9 is
    specifically expressed in prostate cancer

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FOLH1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Folh15 folate hydrolase   --   7 (48.51 cM) 86719352 
    chicken
    (Gallus gallus)
    Aves FOLH16
    Uncharacterized protein
    74(a)
    1 ↔ 1
    1(186845641-186876181)
    lizard
    (Anolis carolinensis)
    Reptilia FOLH16
    Uncharacterized protein
    72(a)
    1 ↔ 1
    3(198775103-198822428)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.87392 Transcribed sequence with weak similarity to protein more 75.41(n)    141999532 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc564292 similar to folate hydrolase (prostate-specific membrane more 73.83(n)   393247  BC049312.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C35C5.23   -- 32(a)   X(11573200-11580288)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS706
    Protein of unknown function involved in vacuolar p...
    20(a)
    1 → many
    X(656254-658689)


    ENSEMBL Gene Tree for FOLH1 (if available)
    TreeFam Gene Tree for FOLH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FOLH1 gene
    NAALADL12  NAALADL22  TFRC2  TFR22  NAALAD22  
    4 SIMAP similar genes for FOLH1 using alignment to 6 protein entries:     FOLH1_HUMAN (see all proteins):
    FOLH1B    NAALAD2    NAALADL1    TFR2

    FOLH1 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for FOLH1 (see all 6)
    PGOHUM00000242409 PGOHUM00000242694 PGOHUM00000258597 PGOHUM00000258599 PGOHUM00000242852


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: FOLH1_HUMAN, Q04609
    Polymorphism: Genetic variation in FOLH1 may be associated with low folate levels and consequent
    hyperhomocysteinemia. This condition can result in increased risk of cardiovascular disease, neural tube defects,
    and cognitive deficits


    10/1505 SNPs in FOLH1 are shown (see all 1505)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363984
    A colorectal cancer sample4--see VAR_0363982 A T mis40--------
    VAR_0288824
    ----see VAR_0288822 V L mis40--------
    rs123633921,2
    C--48948948(-) TCTGTT/CACCAG 5 -- us2k15Minor allele frequency- C:0.20NA WA EA 364
    rs1913308501,2
    --48949208(-) CCCTCA/GAAATA 5 -- us2k10--------
    rs1442665661,2
    --48949244(-) ACACAC/GTTTAT 5 -- us2k10--------
    rs787552491,2
    C--48949261(-) TCTCAT/CGGATT 5 -- us2k12Minor allele frequency- C:0.23NA 122
    rs1865544691,2
    --48949297(-) GCTTCA/CATAAA 5 -- us2k10--------
    rs122815831,2
    C--48949450(-) TCTCCT/CTTTCT 5 -- us2k12Minor allele frequency- C:0.19NA 122
    rs110186921,2
    C--48949528(-) TTTGCG/TCAGAA 5 -- us2k11Minor allele frequency- T:0.50NA 2
    rs110186911,2
    C--48949563(-) CATTGC/TTGACA 5 -- us2k11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for FOLH1 (49168187 - 49230222 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for FOLH1 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2744485CNV Deletion23290073
    esv2666171CNV Deletion23128226
    nsv525454CNV Loss19592680
    nsv469956CNV Gain18288195
    nsv518571CNV Gain19592680
    nsv467874CNV Gain19166990
    nsv832145CNV Gain17160897
    essv23230CNV CNV17122850
    esv542CNV CNV17122850
    essv4365CNV CNV17122850


    Human Gene Mutation Database (HGMD): FOLH1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600934    OMIM disorders: --

    20/42 diseases for FOLH1 (see all 42):    About MalaCards
    prostatitis    hyperhomocysteinemia    prostate small cell carcinoma    canavan disease
    prostate disease    prostate adenocarcinoma    progressive muscular atrophy    small cell carcinoma
    renal clear cell carcinoma    prostate cancer    phenylketonuria    neural tube defects
    neuroendocrine carcinoma    huntington's disease    endometrial adenocarcinoma    abdominal aortic aneurysm
    spina bifida    prostate cancer, progression of    aortic aneurysm    hypogonadism

    1 disease from the University of Copenhagen DISEASES database for FOLH1:
    Prostate cancer

    FOLH1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/42 Novoseek inferred disease relationships for FOLH1 gene (see all 42)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 89 647 15705868 (6), 9508077 (5), 12949815 (5), 18297820 (4) (see all 99)
    prostate carcinoma 76 82 10640975 (5), 9111600 (5), 15733392 (5), 7669565 (3) (see all 34)
    prostatic adenocarcinoma 70.8 27 9763084 (2), 17448023 (2), 7497608 (2), 9815541 (1) (see all 16)
    recurrent prostate cancer 64.2 4 14571413 (1), 19619001 (1), 10579800 (1)
    benign prostatic hyperplasia 59.2 18 9537248 (1), 19084862 (1), 17929272 (1), 7511053 (1) (see all 13)
    tumors 58.8 200 9815541 (4), 7882349 (3), 12679407 (3), 12712410 (3) (see all 99)
    cancer 55.1 84 9763084 (4), 14583590 (3), 9112573 (3), 9192800 (2) (see all 45)
    metastasis 52.5 48 9763084 (4), 17320151 (2), 19343734 (2), 19716160 (2) (see all 30)
    solid tumor 47.2 44 17290063 (3), 15800947 (2), 14610416 (2), 16713605 (2) (see all 20)
    prostatic intraepithelial neoplasia 43.7 5 15168332 (2), 9610707 (1)

    Genetic Association Database (GAD): FOLH1
    Human Genome Epidemiology (HuGE) Navigator: FOLH1 (40 documents)

    Export disorders for FOLH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FOLH1 gene, integrated from 9 sources (see all 516):
    (articles sorted by number of sources associating them with FOLH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene. (PubMed id 9838072)1, 2, 3, 9 O'Keefe D.S.... Heston W.D.W. (1998)
    2. Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia. (PubMed id 11092759)1, 2, 4, 9 Devlin A.M.... Halsted C.H. (2000)
    3. Alternatively spliced variants of prostate-specific membrane antigen RNA: ratio of expression as a potential measurement of progression. (PubMed id 7882349)1, 2, 9 Su S.L.... Heston W.D.W. (1995)
    4. Expression of glutamate carboxypeptidase II in human brain. (PubMed id 17150306)1, 2, 9 Sacha P....Konvalinka J. (2007)
    5. Comparative analysis of prostate-specific membrane antigen (PSMA) versus a prostate-specific membrane antigen-like gene. (PubMed id 14716746)1, 2, 9 O'Keefe D.S.... Heston W.D.W. (2004)
    6. Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs. (PubMed id 18234225)1, 2, 9 Barinka C....Lubkowski J. (2008)
    7. Identification of the N-glycosylation sites on glutamate carboxypeptidase II necessary for proteolytic activity. (PubMed id 15152093)1, 2, 9 Barinka C....Konvalinka J. (2004)
    8. Identification, purification, and subcellular localization of prostate-specific membrane antigen PSM' protein in the LNCaP prostatic carcinoma cell line. (PubMed id 9809977)1, 2, 9 Grauer L.S....Wolfert R.L. (1998)
    9. Molecular characterization of human brain N-acetylated alpha-linked acidic dipeptidase (NAALADase). (PubMed id 9694964)1, 2, 9 Luthi-Carter R.... Coyle J.T. (1998)
    10. Interactions between human glutamate carboxypeptidase II and urea- based inhibitors: structural characterization. (PubMed id 19053759)1, 2, 9 Barinka C.... Lubkowski J. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2346 HGNC: 3788 AceView: FOLH1 Ensembl:ENSG00000086205 euGenes: HUgn2346
    ECgene: FOLH1 Kegg: 2346 H-InvDB: FOLH1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FOLH1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FOLH1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FOLH1 gene:
    Search GeneIP for patents involving FOLH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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