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Aliases for FOCAD Gene

Aliases for FOCAD Gene

  • Focadhesin 2 3
  • KIAA1797 2 3 4 6

External Ids for FOCAD Gene

Previous Symbols for FOCAD Gene

  • KIAA1797

Summaries for FOCAD Gene

GeneCards Summary for FOCAD Gene

FOCAD (Focadhesin) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FOCAD Gene

  • Potential tumor suppressor in gliomas.

Gene Wiki entry for FOCAD Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOCAD Gene

Genomics for FOCAD Gene

Genomic Location for FOCAD Gene

Start:
20,658,309 bp from pter
End:
20,995,955 bp from pter
Size:
337,647 bases
Orientation:
Plus strand

Genomic View for FOCAD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOCAD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOCAD Gene

No data available for Regulatory Elements for FOCAD Gene

Proteins for FOCAD Gene

  • Protein details for FOCAD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VW36-FOCAD_HUMAN
    Recommended name:
    Focadhesin
    Protein Accession:
    Q5VW36
    Secondary Accessions:
    • D3DRJ9
    • Q6ZME1
    • Q8IZG0
    • Q96JM8
    • Q96MS9
    • Q9BVF3
    • Q9NX87

    Protein attributes for FOCAD Gene

    Size:
    1801 amino acids
    Molecular mass:
    200072 Da
    Quaternary structure:
    • Interacts with VCL.
    SequenceCaution:
    • Sequence=BAA91129.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91129.1; Type=Frameshift; Positions=261; Evidence={ECO:0000305}; Sequence=BAD18787.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FOCAD Gene

Proteomics data for FOCAD Gene at MOPED

Post-translational modifications for FOCAD Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys553, Lys577, Lys583, Lys799, and Lys1777

Other Protein References for FOCAD Gene

No data available for DME Specific Peptides for FOCAD Gene

Domains for FOCAD Gene

Protein Domains for FOCAD Gene

InterPro:
Blocks:
ProtoNet:
genes like me logo Genes that share domains with FOCAD: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FOCAD Gene

Function for FOCAD Gene

Molecular function for FOCAD Gene

UniProtKB/Swiss-Prot Function: Potential tumor suppressor in gliomas.

Gene Ontology (GO) - Molecular Function for FOCAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 22427331
genes like me logo Genes that share ontologies with FOCAD: view

Phenotypes for FOCAD Gene

GenomeRNAi human phenotypes for FOCAD:
genes like me logo Genes that share phenotypes with FOCAD: view

miRNA for FOCAD Gene

miRTarBase miRNAs that target FOCAD

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FOCAD Gene

Localization for FOCAD Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOCAD Gene

Membrane; Multi-pass membrane protein. Cell junction, focal adhesion. Note=Colocalizes with VCL in astrocytes.

Gene Ontology (GO) - Cellular Components for FOCAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005925 focal adhesion IDA 22427331
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FOCAD: view

Pathways for FOCAD Gene

SuperPathways for FOCAD Gene

No Data Available

Interacting Proteins for FOCAD Gene

Gene Ontology (GO) - Biological Process for FOCAD Gene

None

No data available for Pathways by source for FOCAD Gene

Transcripts for FOCAD Gene

Unigene Clusters for FOCAD Gene

Focadhesin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FOCAD Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1:
SP2: -
SP3: - -
SP4: - -
SP5:

Relevant External Links for FOCAD Gene

GeneLoc Exon Structure for
FOCAD
ECgene alternative splicing isoforms for
FOCAD

Expression for FOCAD Gene

mRNA expression in normal human tissues for FOCAD Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FOCAD Gene

SOURCE GeneReport for Unigene cluster for FOCAD Gene Hs.136247

mRNA Expression by UniProt/SwissProt for FOCAD Gene

Q5VW36-FOCAD_HUMAN
Tissue specificity: Ubiquitous. High expression in brain followed by testis, muscle, pancreas, heart, ovary, small intestine, placenta, prostate, thymus, kidney, colon, liver, lung, spleen and leukocytes. Expression is reduced in most glioblastomas and all glioblastoma cell lines.
genes like me logo Genes that share expressions with FOCAD: view

Orthologs for FOCAD Gene

This gene was present in the common ancestor of animals.

Orthologs for FOCAD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOCAD 36
  • 99.48 (n)
  • 99.22 (a)
FOCAD 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FOCAD 36
  • 89.25 (n)
  • 89.12 (a)
KIAA1797 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOCAD 36
  • 88.77 (n)
  • 89.45 (a)
FOCAD 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Focad 36
  • 84.63 (n)
  • 83.82 (a)
Focad 16
Focad 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOCAD 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 71 (a)
OneToMany
-- 37
  • 67 (a)
OneToMany
-- 37
  • 68 (a)
OneToMany
-- 37
  • 75 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Focad 36
  • 84.59 (n)
  • 83.93 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 56 (a)
OneToMany
-- 37
  • 52 (a)
OneToMany
FOCAD 36
  • 70.19 (n)
  • 67 (a)
FOCAD 37
  • 67 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia FOCAD 37
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.16271 36
focad 36
  • 56.71 (n)
  • 51.21 (a)
FOCAD 37
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3520 37
  • 21 (a)
OneToOne
Species with no ortholog for FOCAD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOCAD Gene

ENSEMBL:
Gene Tree for FOCAD (if available)
TreeFam:
Gene Tree for FOCAD (if available)

Paralogs for FOCAD Gene

No data available for Paralogs for FOCAD Gene

Variants for FOCAD Gene

Sequence variations from dbSNP and Humsavar for FOCAD Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs13610 -- 20,995,739(-) CCTTA(A/G)CTCTC utr-variant-3-prime
rs868899 -- 20,788,136(+) gcaat(A/G)aaaag intron-variant
rs883599 -- 20,742,649(+) TTCTA(A/T)AATGC intron-variant
rs883600 -- 20,742,688(+) CCTGA(G/T)TGTCT intron-variant
rs883601 -- 20,742,771(+) GGTTC(C/T)TTTAA intron-variant

Relevant External Links for FOCAD Gene

HapMap Linkage Disequilibrium report
FOCAD
Human Gene Mutation Database (HGMD)
FOCAD

No data available for Structural Variations from Database of Genomic Variants (DGV) for FOCAD Gene

Disorders for FOCAD Gene

No disorders were found for FOCAD Gene.

No data available for UniProtKB/Swiss-Prot for FOCAD Gene

Publications for FOCAD Gene

  1. KIAA1797/FOCAD encodes a novel focal adhesion protein with tumour suppressor function in gliomas. (PMID: 22427331) Brockschmidt A. … Weber R.G. (Brain 2012) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3

Products for FOCAD Gene

Sources for FOCAD Gene

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