FOCAD Gene
protein-coding GIFtS: 43
GCID: GC09P020659
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focadhesin(Previous name: KIAA1797 )
(Previous symbol: KIAA1797)
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Aliases
for FOCAD gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Focadhesin1 | | KIAA17971 2 3 | | FLJ203751 |
Export aliases for FOCAD gene to outside databases |
Summaries
for FOCAD gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FOCAD_HUMAN, Q5VW36Function: Potential tumor suppressor in gliomas (By similarity)
Gene Wiki entry for FOCAD (KIAA1797)
|
Genomic Views
for FOCAD gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for FOCAD
Other transcription factors
Search SABiosciences Chromatin IP Primers for FOCAD
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOCAD |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p21 Ensembl cytogenetic band: 9p21.3 HGNC cytogenetic band: 9p21FOCAD Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P020659: view genomic region
(about GC identifiers)
Start:
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20,658,308 bp from pter |
End:
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20,995,954 bp from pter |
Size:
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337,647 bases |
Orientation:
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plus strand |
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Proteins
for FOCAD gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FOCAD_HUMAN, Q5VW36 (See
protein sequence)Recommended Name: Focadhesin Size: 1801 amino acids; 200072 Da
Subunit: Interacts with VCL
Subcellular location: Membrane; Multi-pass membrane protein (Potential). Cell junction, focal adhesion.Note=Colocalizes with VCL in astrocytes
Sequence caution: Sequence=BAA91129.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAA91129.1; Type=Frameshift; Positions=261; Sequence=BAD18787.1; Type=Erroneous initiation; Note=TranslationN-terminally extended;
Secondary accessions: D3DRJ9 Q6ZME1 Q8IZG0 Q96JM8 Q96MS9 Q9BVF3 Q9NX87Explore the universe of human proteins at neXtProt for FOCAD: NX_Q5VW36
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VW36
FOCAD Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060264.3
ENSEMBL proteins: ENSP00000369599 ENSP00000344307
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005925 | focal adhesion |
IDA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
FOCAD for ontologies About GeneDecksing
FOCAD Antibody Products:
Assay Products for FOCAD: |
Protein
Domains /
Families
for FOCAD gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FOCAD for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5VW36ProtoNet protein and cluster: Q5VW36 1 Blocks protein family: IPB000357 HEAT repeat
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Function
for FOCAD gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FOCAD_HUMAN, Q5VW36Function: Potential tumor suppressor in gliomas (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOCAD (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOCAD
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for FOCAD | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOCAD | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FOCAD |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOCAD |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
FOCAD for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FOCAD:
|
Pathways & Interactions
for FOCAD gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FOCAD
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for FOCAD (Q5VW362, 3 ENSP000003443074) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FOCAD gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FOCAD
Search CenterWatch for drugs/clinical trials and news about FOCAD
|
Transcripts
for FOCAD gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FOCAD gene: NM_017794.3 Unigene Cluster for FOCAD: Focadhesin Hs.136247 [show with all ESTs]Unigene Representative Sequence: NM_0177942 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000380249(uc003zog.1 uc003zoh.1) ENST00000338382
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOCAD (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOCAD
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for FOCAD | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FOCAD | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FOCAD |
Additional cDNA sequence: AB058700.1 AK000382.1 AK055116.1 AK056522.1 AK172818.1 AK225483.1 AL512738.1 AY139834.1 BC001246.1 13 DOTS entries: DT.87024835 DT.100748835 DT.121210151 DT.121210105 DT.121210153 DT.91823040 DT.121210162 DT.121210074 DT.121210147 DT.95122152 DT.100022496 DT.121210158 DT.95171587 24/150 AceView cDNA sequences (see all 150): AI383051 AW316588 Z40712 BE790592 AK055116 BF445512 AL512738 AI376928 AI081999 CA424291 BU738727 BM128931 AW473892 AA063556 CK819526 AW087242 BX956980 AY139834 CR607345 BQ057330 AL542355 BP337462 BU678536 CR608016
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for FOCAD About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FOCAD
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Expression
for FOCAD gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FOCAD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTCCTAAGA
About this image
See FOCAD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FOCAD
SOURCE GeneReport for Unigene cluster: Hs.136247
UniProtKB/Swiss-Prot: FOCAD_HUMAN, Q5VW36Tissue specificity: Ubiquitous. High expression in brain followed by testis, muscle, pancreas, heart, ovary, smallintestine, placenta, prostate, thymus, kidney, colon, liver, lung, spleen and leukocytes. Expression is reduced inmost glioblastomas and all glioblastoma cell lines
SABiosciences Custom PCR Arrays for FOCAD
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOCAD
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FOCAD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOCAD | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOCAD | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOCAD |
Orthologs
for FOCAD gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FOCAD gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for FOCAD (if available)
TreeFam Gene Tree for FOCAD (if available) |
Paralogs
for FOCAD gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FOCAD gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FOCAD (20658308 - 20908308 bp, first 250kb of FOCAD)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FOCAD: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOCAD |
|
Disorders
/ Diseases
for FOCAD gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FOCAD for disorders About GeneDecksing
OMIM gene information: 614606
OMIM disorders: --
2  diseases for FOCAD: About MalaCardsglioblastoma prostatitis
Export disorders for FOCAD gene to outside databases
|
Publications
for FOCAD gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FOCAD gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with FOCAD) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- KIAA1797/FOCAD encodes a novel focal adhesion protein with tumour suppressor function in gliomas. (PubMed id 22427331)1, 2, 3 Brockschmidt A.... Weber R.G. (2012)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
- A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Bivariate genetic association of KIAA1797 with heart rate in American Indians: the Strong Heart Family Study. (PubMed id 20601674)1 Melton P.E....Almasy L. (2010)
|
External Searches for FOCAD gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FOCAD gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FOCAD gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FOCAD gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FOCAD | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FOCAD gene:
Search GeneIP for patents involving FOCAD
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FOCAD gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FOCAD | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FOCAD | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FOCAD | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FOCAD | | OriGene 3'-UTR Clone for FOCAD | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FOCAD | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FOCAD | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FOCAD | | OriGene Custom Protein Services for FOCAD | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FOCAD | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FOCAD | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FOCAD | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FOCAD | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FOCAD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FOCAD |
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| | | | Search Tocris compounds for FOCAD |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FOCAD |
|  |  |  | | | | Search ThermoFisher Antibodies for FOCAD |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FOCAD |
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