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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FNTB Gene

protein-coding   GIFtS: 64
GCID: GC14P065454

Farnesyltransferase, CAAX Box, Beta

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Farnesyltransferase, CAAX Box, Beta1 2     EC 2.5.1.583 8
Ras Proteins Prenyltransferase Subunit Beta2 3     FPTB2
FTase-beta2 3     Protein Farnesyltransferase Subunit Beta2
CAAX Farnesyltransferase Subunit Beta2 3     

External Ids:    HGNC: 37851   Entrez Gene: 23422   Ensembl: ENSG000002573657   OMIM: 1346365   UniProtKB: P493563   

Export aliases for FNTB gene to outside databases

Previous GC identifers: GC14P062781 GC14P059247 GC14P063443 GC14P064523 GC14P065381


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FNTB Gene: 
FNTB (farnesyltransferase, CAAX box, beta) is a protein-coding gene. Diseases associated with FNTB include colorectal cancer, and endotheliitis, and among its related super-pathways are Visual signal transduction- Rods and Retinoid metabolism and transport. GO annotations related to this gene include protein farnesyltransferase activity and metal ion binding. An important paralog of this gene is CHURC1-FNTB.

UniProtKB/Swiss-Prot: FNTB_HUMAN, P49356
Function: Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth
position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding

Gene Wiki entry for FNTB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FNTB gene promoter:
         RFX1   C/EBPbeta   USF1   FOXF2   Egr-1   Nkx2-2   Arnt   USF-1   c-Myb   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFNTB promoter sequence
   Search SABiosciences Chromatin IP Primers for FNTB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FNTB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.3   Ensembl cytogenetic band:  14q23.3   HGNC cytogenetic band: 14q23.3

FNTB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FNTB gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P065454:  view genomic region     (about GC identifiers)

Start:
65,453,438 bp from pter      End:
65,529,370 bp from pter
Size:
75,933 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FNTB_HUMAN, P49356 (See protein sequence)
Recommended Name: Protein farnesyltransferase subunit beta  
Size: 437 amino acids; 48774 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Heterodimer of an alpha and a beta subunit
6/14 PDB 3D structures from and Proteopedia for FNTB (see all 14):
1JCQ (3D)        1LD7 (3D)        1LD8 (3D)        1MZC (3D)        1S63 (3D)        1SA4 (3D)    
Secondary accessions: B2RDX6

Explore the universe of human proteins at neXtProt for FNTB: NX_P49356

Explore proteomics data for FNTB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49356

  • 4/7 DME Specific Peptides for FNTB (P49356) (see all 7)
     EAHGGYT  CPPSSSP  YHTCYCL  NKLVDGCY 

    FNTB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FNTB Protein Expression
    REFSEQ proteins: NP_002019.1  
    ENSEMBL proteins: 
     ENSP00000246166  
    Reactome Protein details: P49356
    Human Recombinant Protein Products for FNTB: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for FNTB
    OriGene MassSpec for FNTB 
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    Novus Biologicals FNTB Proteins
    Novus Biologicals FNTB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005875microtubule associated complex IDA19228685
    GO:0005965protein farnesyltransferase complex IEA--
    GO:0043234protein complex ----

    FNTB for ontologies           About GeneDecksing



    FNTB Antibody Products: 
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    Assay Products for FNTB: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR026872 FTB
     IPR008930 Terpenoid_cyclase/PrenylTrfase
     IPR001330 Prenyltrans

    Graphical View of Domain Structure for InterPro Entry P49356

    ProtoNet protein and cluster: P49356

    1 Blocks protein domain: IPB001330 Prenyltransferase/squalene oxidase

    UniProtKB/Swiss-Prot: FNTB_HUMAN, P49356
    Similarity: Belongs to the protein prenyltransferase subunit beta family
    Similarity: Contains 5 PFTB repeats


    FNTB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FNTB_HUMAN, P49356
    Function: Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth
    position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding
    Catalytic activity: Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate

         Genatlas biochemistry entry for FNTB:
    CAAX farnesyltransferase,beta subunit,promoting the prenylation of Ras,first step of a series of post
    translational modification of RAS,required for its association with the inner surface of the plasma membrane,also
    involved in maturation of other proteins including Ras family members,the gamma subunit of G proteins and nuclear
    lamins

         Enzyme Number (IUBMB): EC 2.5.1.581 2

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004311farnesyltranstransferase activity IEA--
    GO:0004660contributes to protein farnesyltransferase activity IDA19228685
    GO:0005515protein binding IPI11687658
    GO:0046872metal ion binding IEA--
         
    FNTB for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Fntb):
     cellular  embryogenesis  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  respiratory system  tumorigenesis 

    FNTB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FNTB: Fntbtm1.2Mbrg Fntbtm1.1Bbd

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FNTB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FNTB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FNTB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FNTB 

    miRNA
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    miRTarBase miRNAs that target FNTB:
    hsa-mir-346 (MIRT004223)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FNTB
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate FNTB (see all 20):
    hsa-miR-142-3p hsa-miR-429 hsa-miR-3651 hsa-miR-374c hsa-miR-1244 hsa-miR-330-3p hsa-miR-376c hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidFNTB 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNTB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FNTB About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Visual signal transduction- Rods
    The phototransduction cascade0.54
    Inactivation, recovery and regulation of the phototransduction cascade0.51
    2Visual phototransduction
    Visual phototransduction0.48
    Diseases associated with visual transduction0.47
    3G-protein signaling K-RAS regulation pathway
    G-protein signaling K-RAS regulation pathway0.96
    4Signaling by GPCR
    Signal Transduction0.55
    5superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
    Terpenoid backbone biosynthesis0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for FNTB
        G-protein signaling K-RAS regulation pathway
    G-protein signaling RhoB regulation pathway
    G-protein signaling H-RAS regulation pathway


    3 GeneGo (Thomson Reuters) Pathways for FNTB
        G-protein signaling H-RAS regulation pathway
    G-protein signaling RhoB regulation pathway
    G-protein signaling K-RAS regulation pathway


    5/6        Reactome Pathways for FNTB (see all 6)
        Diseases associated with visual transduction
    The phototransduction cascade
    Signal Transduction
    Visual phototransduction
    Disease


    1         Kegg Pathway  (Kegg details for FNTB):
        Terpenoid backbone biosynthesis


    FNTB for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FNTB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/46 Interacting proteins for FNTB (P493561, 2, 3 ENSP000002461664) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007603phototransduction, visible light TAS--
    GO:0008284positive regulation of cell proliferation ----
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0010035response to inorganic substance IEA--
    GO:0014070response to organic cyclic compound IEA--

    FNTB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for FNTB:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FNTB

    1 HMDB Compound for FNTB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Farnesyl pyrophosphate(2E,6E)-Farnesyl diphosphate (see all 15)13058-04-3--

    10 DrugBank Compounds for FNTB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE-- --target--10592235
    (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE-- --target--10592235
    (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE-- --target--10592235
    2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE-- --target--10592235
    4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE-- --target--10592235
    ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID-- --target--10592235
    FARNESYL-- --target--10592235
    FARNESYL DIPHOSPHATE-- --target--10592235
    GERANYLGERANYL DIPHOSPHATE-- --target--10592235
    [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about FNTB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FNTB gene: 
    NM_002028.3  

    Unigene Cluster for FNTB:

    Farnesyltransferase, CAAX box, beta
    Hs.325531  [show with all ESTs]
    Unigene Representative Sequence: NM_001202559
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000246166(uc010tsl.2 uc010tsm.2 uc001xia.3) ENST00000555372
    ENST00000555742 ENST00000554210 ENST00000554334 ENST00000556709 ENST00000555618
    ENST00000557300
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FNTB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FNTB

    Additional mRNA sequence: 

    AK093298.1 AK225917.1 AK295972.1 AK315714.1 BC013574.1 BC020232.1 BC035148.1 BC052775.1 
    BX248269.1 L00635.1 L10414.1 

    16 DOTS entries:

    DT.444290  DT.91732520  DT.100835090  DT.75149664  DT.100840472  DT.120751748  DT.100789404  DT.100738434 
    DT.100789405  DT.92427119  DT.100692416  DT.100705079  DT.120751814  DT.91680670  DT.97805221  DT.92024014 

    24/225 AceView cDNA sequences (see all 225):

    BQ218949 BM662406 CB118372 BQ212962 BG676869 CA454405 BF724777 CB144274 
    BM827804 AI811595 BI087237 NM_002028 W74655 BQ226383 AI347875 BM852620 
    AA337419 CR622524 AA701468 BU153989 BP344443 CR609252 BE407340 CA420933 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FNTB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGCGCTTAG
    FNTB Expression
    About this image


    See FNTB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FNTB

    SOURCE GeneReport for Unigene cluster: Hs.325531
        SABiosciences Custom PCR Arrays for FNTB
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNTB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FNTB gene from 9/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fntb1 , 5 farnesyltransferase, CAAX box, beta1, 5 90.16(n)1
    95.88(a)1
      12 (33.73 cM)5
    1106061  NM_145927.21  NP_666039.11 
     767655895 
    chicken
    (Gallus gallus)
    Aves LOC1008576831 protein farnesyltransferase subunit beta-like 76.42(n)
    83.73(a)
      100857683  XM_003643780.1  XP_003643828.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    80(a)
    1 → many
    1(93645197-93676840)
    zebrafish
    (Danio rerio)
    Actinopterygii 570450492   -- 76.32(n)    57045049 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG175651 , 3 RAB-protein geranylgeranyltransferase3
    CG175651
    52(a)3
    57.31(n)1
    53.74(a)1
      419891  NM_142283.31  NP_650540.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F23B12.63
    fntb-11
    protein farnesyltransferase beta
    subunit3
    Protein FNTB-11
    46(a)3
    51.01(n)1
    48.07(a)1
      V(14450340-14452041)3
    1799461  NM_074179.41  NP_506580.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAM1(YDL090C)4
    RAM11
    Beta subunit of the CAAX farnesyltransferase (FTase) more4
    Ram1p1
    46.5(n)1
    42.54(a)1
      4(296329-295034)4
    8514681, 4  NP_010193.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ERA11 protein farnesyltransferase subunit beta 54.25(n)
    49.22(a)
      834026  NM_123392.1  NP_198844.1 
    rice
    (Oryza sativa)
    Liliopsida Os.209912 Oryza sativa (japonica cultivar-group) putative farnesyltranstransferase more 74.79(n)    NM_191123.1 


    ENSEMBL Gene Tree for FNTB (if available)
    TreeFam Gene Tree for FNTB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FNTB gene
    CHURC1-FNTB2  
    1 SIMAP similar gene for FNTB using alignment to 2 protein entries:     FNTB_HUMAN (see all proteins):
    CHURC1-FNTB

    FNTB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FNTB:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2748787CNV Deletion23290073
    esv2506970CNV Deletion19546169
    esv2748779CNV Deletion23290073
    esv2665422CNV Deletion23128226
    nsv832816CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 134636    OMIM disorders: --

    2 diseases for FNTB:    About MalaCards
    colorectal cancer    endotheliitis


    FNTB for disorders           About GeneDecksing

    Genetic Association Database (GAD): FNTB
    Human Genome Epidemiology (HuGE) Navigator: FNTB (1 document)

    Export disorders for FNTB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FNTB gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with FNTB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences. (PubMed id 8276393)1, 2, 3 Andres D.A.... Francke U. (1993)
    2. Polymorphisms of the lamina maturation pathway and th eir association with the metabolic syndrome: the DESIR prospective study. (PubMed id 19841875)1, 4 Fontaine-Bisson B....Morange P.E. (2010)
    3. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PubMed id 19862010)1, 4 Ganesh S.K....Lin J.P. (2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents. (PubMed id 12825937)1, 2 deSolms S.J.... Taylor J.S. (2003)
    7. 3-aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency. (PubMed id 12036349)1, 2 Bell I.M.... Zartman C.B. (2002)
    8. The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. (PubMed id 11687658)1, 2 Long S.B.... Beese L.S. (2001)
    9. Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases. (PubMed id 8494894)1, 2 Omer C.A.... Kohl N.E. (1993)
    10. Seventy-five genetic loci influencing the human red bl ood cell. (PubMed id 23222517)1 van der Harst P....Chambers J.C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2342 HGNC: 3785 AceView: FNTB Ensembl:ENSG00000257365 euGenes: HUgn2342
    ECgene: FNTB Kegg: 2342 H-InvDB: FNTB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FNTB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FNTB gene:
    Search GeneIP for patents involving FNTB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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