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Aliases for FNTB Gene

Aliases for FNTB Gene

  • Farnesyltransferase, CAAX Box, Beta 2 3 5
  • Ras Proteins Prenyltransferase Subunit Beta 3 4
  • CAAX Farnesyltransferase Subunit Beta 3 4
  • EC 2.5.1.58 4 63
  • FTase-Beta 3 4
  • FPTB 3

External Ids for FNTB Gene

Previous GeneCards Identifiers for FNTB Gene

  • GC14P062781
  • GC14P059247
  • GC14P063443
  • GC14P064523
  • GC14P065381
  • GC14P065454

Summaries for FNTB Gene

GeneCards Summary for FNTB Gene

FNTB (Farnesyltransferase, CAAX Box, Beta) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Metabolism of fat-soluble vitamins. GO annotations related to this gene include drug binding and farnesyltranstransferase activity. An important paralog of this gene is CHURC1-FNTB.

UniProtKB/Swiss-Prot for FNTB Gene

  • Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.

Gene Wiki entry for FNTB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNTB Gene

Genomics for FNTB Gene

Regulatory Elements for FNTB Gene

Promoters for FNTB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FNTB on UCSC Golden Path with GeneCards custom track

Genomic Location for FNTB Gene

Chromosome:
14
Start:
64,986,720 bp from pter
End:
65,062,652 bp from pter
Size:
75,933 bases
Orientation:
Plus strand

Genomic View for FNTB Gene

Genes around FNTB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNTB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNTB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNTB Gene

Proteins for FNTB Gene

  • Protein details for FNTB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49356-FNTB_HUMAN
    Recommended name:
    Protein farnesyltransferase subunit beta
    Protein Accession:
    P49356
    Secondary Accessions:
    • B2RDX6
    • B4E1A0

    Protein attributes for FNTB Gene

    Size:
    437 amino acids
    Molecular mass:
    48774 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Heterodimer of FNTA and FNTB.

    Three dimensional structures from OCA and Proteopedia for FNTB Gene

    Alternative splice isoforms for FNTB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FNTB Gene

Proteomics data for FNTB Gene at MOPED

Post-translational modifications for FNTB Gene

  • Ubiquitination at Lys 63
  • Modification sites at PhosphoSitePlus

Other Protein References for FNTB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for FNTB Gene

Protein Domains for FNTB Gene

Graphical View of Domain Structure for InterPro Entry

P49356

UniProtKB/Swiss-Prot:

FNTB_HUMAN :
  • Belongs to the protein prenyltransferase subunit beta family.
  • Contains 5 PFTB repeats.
Family:
  • Belongs to the protein prenyltransferase subunit beta family.
Similarity:
  • Contains 5 PFTB repeats.
genes like me logo Genes that share domains with FNTB: view

No data available for Gene Families for FNTB Gene

Function for FNTB Gene

Molecular function for FNTB Gene

GENATLAS Biochemistry:
CAAX farnesyltransferase,beta subunit,promoting the prenylation of Ras,first step of a series of post translational modification of RAS,required for its association with the inner surface of the plasma membrane,also involved in maturation of other proteins including Ras family members,the gamma subunit of G proteins and nuclear lamins
UniProtKB/Swiss-Prot CatalyticActivity:
Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
UniProtKB/Swiss-Prot Function:
Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.

Enzyme Numbers (IUBMB) for FNTB Gene

Gene Ontology (GO) - Molecular Function for FNTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004311 farnesyltranstransferase activity IEA --
GO:0005515 protein binding IEA,IPI 11687658
GO:0019840 isoprenoid binding IEA --
genes like me logo Genes that share ontologies with FNTB: view
genes like me logo Genes that share phenotypes with FNTB: view

Animal Models for FNTB Gene

MGI Knock Outs for FNTB:

Animal Model Products

miRNA for FNTB Gene

miRTarBase miRNAs that target FNTB

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FNTB Gene

Localization for FNTB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FNTB Gene COMPARTMENTS Subcellular localization image for FNTB gene
Compartment Confidence
cytoskeleton 4
cytosol 4

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FNTB Gene

Pathways & Interactions for FNTB Gene

genes like me logo Genes that share pathways with FNTB: view

Gene Ontology (GO) - Biological Process for FNTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007603 phototransduction, visible light TAS --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0010035 response to inorganic substance IEA --
GO:0016056 rhodopsin mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with FNTB: view

No data available for SIGNOR curated interactions for FNTB Gene

Drugs & Compounds for FNTB Gene

(16) Drugs for FNTB Gene - From: HMDB, DGIdb, ApexBio, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
farnesyl diphosphate Experimental Pharma Antagonist, Target 0
(11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE Experimental Pharma Target 0
(20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE Experimental Pharma Target 0
(20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE Experimental Pharma Target 0
[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Experimental Pharma Target 0
genes like me logo Genes that share compounds with FNTB: view

Transcripts for FNTB Gene

Unigene Clusters for FNTB Gene

Farnesyltransferase, CAAX box, beta:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FNTB Gene

No ASD Table

Relevant External Links for FNTB Gene

GeneLoc Exon Structure for
FNTB
ECgene alternative splicing isoforms for
FNTB

Expression for FNTB Gene

mRNA expression in normal human tissues for FNTB Gene

mRNA differential expression in normal tissues according to GTEx for FNTB Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FNTB Gene



SOURCE GeneReport for Unigene cluster for FNTB Gene Hs.325531

genes like me logo Genes that share expression patterns with FNTB: view

Protein tissue co-expression partners for FNTB Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FNTB Gene

Orthologs for FNTB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FNTB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FNTB 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FNTB 35
  • 92.07 (n)
  • 97.03 (a)
dog
(Canis familiaris)
Mammalia FNTB 35
  • 93.04 (n)
  • 96.79 (a)
FNTB 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fntb 36
  • 96 (a)
OneToOne
Fntb 16
Fntb 35
  • 90.16 (n)
  • 95.88 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fntb 35
  • 89.63 (n)
  • 96.57 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 84 (a)
OneToMany
FNTB 35
  • 76.25 (n)
  • 83.33 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fntb 35
  • 69.58 (n)
  • 75.06 (a)
zebrafish
(Danio rerio)
Actinopterygii fntb 35
  • 68.92 (n)
  • 72.93 (a)
fntb 36
  • 70 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001729 35
  • 57.33 (n)
  • 50.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17565 36
  • 48 (a)
OneToMany
CG17565 37
  • 52 (a)
CG17565 35
  • 57.27 (n)
  • 53.46 (a)
worm
(Caenorhabditis elegans)
Secernentea F23B12.6 37
  • 46 (a)
fntb-1 36
  • 45 (a)
OneToMany
fntb-1 35
  • 50.72 (n)
  • 47.31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAM1 36
  • 36 (a)
OneToMany
RAM1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ERA1 35
  • 54.25 (n)
  • 48.96 (a)
corn
(Zea mays)
Liliopsida Zm.14070 35
rice
(Oryza sativa)
Liliopsida Os.20991 35
Os01g0737800 35
  • 56.13 (n)
  • 53.24 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.7380 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToMany
Species with no ortholog for FNTB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for FNTB Gene

ENSEMBL:
Gene Tree for FNTB (if available)
TreeFam:
Gene Tree for FNTB (if available)

Paralogs for FNTB Gene

Paralogs for FNTB Gene

(3) SIMAP similar genes for FNTB Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FNTB: view

Variants for FNTB Gene

Structural Variations from Database of Genomic Variants (DGV) for FNTB Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV Deletion 23290073
nsv832816 CNV Gain 17160897
esv2506970 CNV Deletion 19546169
esv2748787 CNV Deletion 23290073
esv2665422 CNV Deletion 23128226

Variation tolerance for FNTB Gene

Residual Variation Intolerance Score: 28.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FNTB Gene

HapMap Linkage Disequilibrium report
FNTB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for FNTB Gene

Disorders for FNTB Gene

Relevant External Links for FNTB

Genetic Association Database (GAD)
FNTB
Human Genome Epidemiology (HuGE) Navigator
FNTB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FNTB

No disorders were found for FNTB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FNTB Gene

Publications for FNTB Gene

  1. cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences. (PMID: 8276393) Andres D.A. … Francke U. (Genomics 1993) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  4. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. (PMID: 23720494) Evans D.M. … Whitfield J.B. (Hum. Mol. Genet. 2013) 3
  5. Farnesyltransferase inhibitor attenuates methamphetamine toxicity-induced Ras proteins activation and cell death in neuroblastoma SH-SY5Y cells. (PMID: 23643986) Pirompul N. … Chetsawang B. (Neurosci. Lett. 2013) 3

Products for FNTB Gene

Sources for FNTB Gene

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