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FNTB Gene

protein-coding   GIFtS: 63
GCID: GC14P065381

Farnesyltransferase, CAAX Box, Beta

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Farnesyltransferase, CAAX Box, Beta1 2     EC 2.5.1.583 8
Ras Proteins Prenyltransferase Subunit Beta2 3     FPTB2
FTase-beta2 3     Protein Farnesyltransferase Subunit Beta2
CAAX Farnesyltransferase Subunit Beta2 3     

External Ids:    HGNC: 37851   Entrez Gene: 23422   Ensembl: ENSG000002573657   OMIM: 1346365   UniProtKB: P493563   

Export aliases for FNTB gene to outside databases

Previous GC identifers: GC14P062781 GC14P059247 GC14P063443 GC14P064523 GC14P065454


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FNTB Gene:
FNTB (farnesyltransferase, CAAX box, beta) is a protein-coding gene. GO annotations related to this gene include farnesyltranstransferase activity and protein farnesyltransferase activity. An important paralog of this gene is CHURC1-FNTB.

UniProtKB/Swiss-Prot: FNTB_HUMAN, P49356
Function: Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from
farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the
C-terminal sequence Cys-aliphatic-aliphatic-X

Gene Wiki entry for FNTB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the FNTB gene promoter:
         RFX1   C/EBPbeta   USF1   FOXF2   Egr-1   Nkx2-2   Arnt   USF-1   c-Myb   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFNTB promoter sequence
   Search Chromatin IP Primers for FNTB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FNTB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.3   Ensembl cytogenetic band:  14q23.3   HGNC cytogenetic band: 14q23.3

FNTB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FNTB gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P065381:  view genomic region     (about GC identifiers)

Start:
65,381,203 bp from pter      End:
65,529,370 bp from pter
Size:
148,168 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FNTB_HUMAN, P49356 (See protein sequence)
Recommended Name: Protein farnesyltransferase subunit beta  
Size: 437 amino acids; 48774 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Heterodimer of FNTA and FNTB
Selected PDB 3D structures from and Proteopedia for FNTB (see all 14):
1JCQ (3D)        1LD7 (3D)        1LD8 (3D)        1MZC (3D)        1S63 (3D)        1SA4 (3D)    
Secondary accessions: B2RDX6

Explore the universe of human proteins at neXtProt for FNTB: NX_P49356

Explore proteomics data for FNTB at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys63
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FNTB (P49356) (see all 7)
     EAHGGYT  CPPSSSP  YHTCYCL  NKLVDGCY 


    See FNTB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002019.1  
    ENSEMBL proteins: 
     ENSP00000246166   ENSP00000406393   ENSP00000443140  
    Reactome Protein details: P49356

    FNTB Human Recombinant Protein Products:

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    Novus Biologicals FNTB Proteins
    Novus Biologicals FNTB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for FNTB 

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for FNTB 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR026872 FTB
     IPR008930 Terpenoid_cyclase/PrenylTrfase
     IPR001330 Prenyltrans

    Graphical View of Domain Structure for InterPro Entry P49356

    ProtoNet protein and cluster: P49356

    1 Blocks protein domain: IPB001330 Prenyltransferase/squalene oxidase

    UniProtKB/Swiss-Prot: FNTB_HUMAN, P49356
    Similarity: Belongs to the protein prenyltransferase subunit beta family
    Similarity: Contains 5 PFTB repeats


    Find genes that share domains with FNTB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FNTB_HUMAN, P49356
    Function: Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from
    farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the
    C-terminal sequence Cys-aliphatic-aliphatic-X
    Catalytic activity: Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate

         Genatlas biochemistry entry for FNTB:
    CAAX farnesyltransferase,beta subunit,promoting the prenylation of Ras,first step of a series of post
    translational modification of RAS,required for its association with the inner surface of the plasma membrane,also
    involved in maturation of other proteins including Ras family members,the gamma subunit of G proteins and nuclear
    lamins

         Enzyme Number (IUBMB): EC 2.5.1.581 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004311farnesyltranstransferase activity IEA--
    GO:0004660contributes to protein farnesyltransferase activity IDA19228685
    GO:0005515protein binding IPI11687658
    GO:0008270zinc ion binding IDA16893176
         
    Find genes that share ontologies with FNTB           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Fntb):
     cellular  embryogenesis  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  respiratory system  tumorigenesis 

    Find genes that share phenotypes with FNTB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FNTB: Fntbtm1.2Mbrg Fntbtm1.1Bbd

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FNTB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FNTB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FNTB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FNTB

    miRNA
    Products:
        
    miRTarBase miRNAs that target FNTB:
    hsa-mir-24-3p (MIRT030444), hsa-mir-346 (MIRT004223), hsa-mir-183-5p (MIRT047154)

    Block miRNA regulation of human, mouse, rat FNTB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FNTB (see all 20):
    hsa-miR-142-3p hsa-miR-429 hsa-miR-3651 hsa-miR-374c hsa-miR-1244 hsa-miR-330-3p hsa-miR-376c hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidFNTB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FNTB
    Predesigned siRNA for gene silencing in human, mouse, rat FNTB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FNTB

    Clone
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    OriGene ORF clones in mouse, rat for FNTB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FNTB (NM_002028)
    Sino Biological Human cDNA Clone for FNTB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FNTB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNTB

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNTB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005875microtubule associated complex IDA19228685
    GO:0005965protein farnesyltransferase complex IDA16893176
    GO:0043234protein complex ----

    Find genes that share ontologies with FNTB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FNTB About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1The phototransduction cascade
    The phototransduction cascade0.51
    Inactivation, recovery and regulation of the phototransduction cascade0.49
    2Diseases associated with visual transduction
    Visual phototransduction0.44
    Diseases associated with visual transduction0.43
    3Signaling by GPCR
    Signal Transduction0.58
    4superpathway of cholesterol biosynthesis
    Terpenoid backbone biosynthesis0.34
    5G protein signaling RhoB regulation pathway
    G protein signaling RhoB regulation pathway


    Find genes that share SuperPaths with FNTB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for FNTB
        G-protein signaling H-RAS regulation pathway
    G-protein signaling RhoB regulation pathway
    G-protein signaling K-RAS regulation pathway


    1 Reactome Pathway for FNTB
        Inactivation, recovery and regulation of the phototransduction cascade


    1 Kegg Pathway  (Kegg details for FNTB):
        Terpenoid backbone biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FNTB
    Interactions:

        Search GeneGlobe Interaction Network for FNTB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FNTB (P493561, 2, 3 ENSP000002461664) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development ----
    GO:0007603phototransduction, visible light TAS--
    GO:0008284positive regulation of cell proliferation ----
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0010035response to inorganic substance IEA--

    Find genes that share ontologies with FNTB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FNTB

    1 HMDB Compound for FNTB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Farnesyl pyrophosphate(2E,6E)-Farnesyl diphosphate (see all 15)13058-04-3--

    10 DrugBank Compounds for FNTB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE-- --target--10592235
    (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE-- --target--10592235
    (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE-- --target--10592235
    2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE-- --target--10592235
    4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE-- --target--10592235
    ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID-- --target--10592235
    FARNESYL-- --target--10592235
    FARNESYL DIPHOSPHATE-- --target--10592235
    GERANYLGERANYL DIPHOSPHATE-- --target--10592235
    [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FNTB gene: 
    NM_002028.3  

    Unigene Cluster for FNTB:

    Farnesyltransferase, CAAX box, beta
    Hs.325531  [show with all ESTs]
    Unigene Representative Sequence: NM_001202559
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000246166(uc010tsl.2 uc010tsm.2 uc001xia.3) ENST00000555372
    ENST00000555742 ENST00000554210 ENST00000554334 ENST00000556709 ENST00000555618
    ENST00000557300 ENST00000447296 ENST00000542227
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FNTB (see all 20):
    hsa-miR-142-3p hsa-miR-429 hsa-miR-3651 hsa-miR-374c hsa-miR-1244 hsa-miR-330-3p hsa-miR-376c hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidFNTB 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FNTB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FNTB
      QuantiTect SYBR Green Assays in human, mouse, rat FNTB
      QuantiFast Probe-based Assays in human, mouse, rat FNTB

    Additional mRNA sequence: 

    AK093298.1 AK225917.1 AK295972.1 AK315714.1 BC013574.1 BC020232.1 BC035148.1 BC052775.1 
    BX248269.1 L00635.1 L10414.1 

    16 DOTS entries:

    DT.444290  DT.91732520  DT.100835090  DT.75149664  DT.100840472  DT.120751748  DT.100789404  DT.100738434 
    DT.100789405  DT.92427119  DT.100692416  DT.100705079  DT.120751814  DT.91680670  DT.97805221  DT.92024014 

    Selected AceView cDNA sequences (see all 225):

    BP369328 AW262685 BQ638975 BM721387 BM809674 BE407340 BI755078 BM674471 
    L10414 BG676869 BU153989 BP344443 CR609252 W74655 BU740458 BX952567 
    BF724777 BX394424 BQ218949 AI347875 AW770106 W49805 BM662406 BU507294 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FNTB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGCGCTTAG
    FNTB Expression
    About this image

    FNTB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FNTB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.325531
        Custom PCR Arrays for FNTB
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat FNTB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNTB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FNTB gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fntb1 , 5 farnesyltransferase, CAAX box, beta1, 5 90.16(n)1
    95.88(a)1
      12 (33.73 cM)5
    1106061  NM_145927.21  NP_666039.11 
     767655895 
    chicken
    (Gallus gallus)
    Aves FNTB1 farnesyltransferase, CAAX box, beta 76.25(n)
    83.33(a)
      100857683  XM_003643780.2  XP_003643828.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    80(a)
    1 → many
    1(93645197-93676840)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fntb1 farnesyltransferase, CAAX box, beta 69.58(n)
    75.06(a)
      550012  NM_001017258.2  NP_001017258.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570450492   -- 76.32(n)    57045049 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG175651 , 3 RAB-protein geranylgeranyltransferase3
    CG175651
    52(a)3
    57.27(n)1
    53.46(a)1
      419891  NM_142283.41  NP_650540.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F23B12.63
    fntb-11
    protein farnesyltransferase beta
    subunit3
    fntb-11
    46(a)3
    50.72(n)1
    47.31(a)1
      V(14450340-14452041)3
    1799461  NM_074179.51  NP_506580.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAM1(YDL090C)4 Beta subunit of the CAAX farnesyltransferase (FTase) more   --   4(296329-295034) 851468  NP_010193.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ERA11 ERA1 54.25(n)
    48.96(a)
      834026  NM_123392.1  NP_198844.1 
    rice
    (Oryza sativa)
    Liliopsida Os.209912 Oryza sativa (japonica cultivar-group) putative farnesyltranstransferase more 74.79(n)    NM_191123.1 


    ENSEMBL Gene Tree for FNTB (if available)
    TreeFam Gene Tree for FNTB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FNTB gene
    CHURC1-FNTB2  
    3 SIMAP similar genes for FNTB using alignment to 3 protein entries:     FNTB_HUMAN (see all proteins):
    CHURC1-FNTB    CHURC1    RABGGTB

    Find genes that share paralogs with FNTB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FNTB:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748787CNV Deletion23290073
    esv2506970CNV Deletion19546169
    esv2748779CNV Deletion23290073
    esv2665422CNV Deletion23128226
    nsv832816CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FNTB
    DNA2.0 Custom Variant and Variant Library Synthesis for FNTB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 134636    OMIM disorders: --


    Find genes that share disorders with FNTB           About GenesLikeMe

    Genetic Association Database (GAD): FNTB
    Human Genome Epidemiology (HuGE) Navigator: FNTB (1 document)

    Export disorders for FNTB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FNTB gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with FNTB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences. (PubMed id 8276393)1, 2, 3 Andres D.A.... Francke U. (Genomics 1993)
    2. Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study. (PubMed id 19841875)1, 4 Fontaine-Bisson B....Morange P.E. (J. Mol. Med. 2010)
    3. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PubMed id 19862010)1, 4 Ganesh S.K....Lin J.P. (Nat. Genet. 2009)
    4. Conversion of protein farnesyltransferase to a geranylgeranyltransferase. (PubMed id 16893176)1, 2 Terry K.L.... Beese L.S. (Biochemistry 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. (PubMed id 15451670)1, 2 Reid T.S....Beese L.S. (J. Mol. Biol. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents. (PubMed id 12825937)1, 2 deSolms S.J.... Taylor J.S. (J. Med. Chem. 2003)
    9. 3-aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency. (PubMed id 12036349)1, 2 Bell I.M.... Zartman C.B. (J. Med. Chem. 2002)
    10. The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. (PubMed id 11687658)1, 2 Long S.B.... Beese L.S. (Proc. Natl. Acad. Sci. U.S.A. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2342 HGNC: 3785 AceView: FNTB Ensembl:ENSG00000257365 euGenes: HUgn2342
    ECgene: FNTB Kegg: 2342 H-InvDB: FNTB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FNTB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FNTB gene:
    Search GeneIP for patents involving FNTB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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