Aliases for FNTA Gene
- Farnesyltransferase, CAAX Box, Alpha 2 3 5
- Protein Farnesyltransferase/Geranylgeranyltransferase Type-1 Subunit Alpha 2 3
- Protein Prenyltransferase Alpha Subunit Repeat Containing 2 2 3
- Ras Proteins Prenyltransferase Subunit Alpha 3 4
- GGTase-I-Alpha 3 4
- FTase-Alpha 3 4
- Type I Protein Geranyl-Geranyltransferase Alpha Subunit 3
- Type I Protein Geranyl-Geranyltransferase Subunit Alpha 4
External Ids for FNTA Gene
Previous GeneCards Identifiers for FNTA Gene
Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010]
GeneCards Summary for FNTA Gene
FNTA (Farnesyltransferase, CAAX Box, Alpha) is a Protein Coding gene. Among its related pathways are G-protein signaling_Rap1B regulation pathway and G-protein signaling_Regulation of RAC1 activity. Gene Ontology (GO) annotations related to this gene include microtubule binding and alpha-tubulin binding.
UniProtKB/Swiss-Prot for FNTA Gene
Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.