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Aliases for FNTA Gene

Aliases for FNTA Gene

  • Farnesyltransferase, CAAX Box, Alpha 2 3 5
  • Protein Prenyltransferase Alpha Subunit Repeat Containing 2 2 3
  • Ras Proteins Prenyltransferase Subunit Alpha 3 4
  • GGTase-I-Alpha 3 4
  • FTase-Alpha 3 4
  • Protein Farnesyltransferase/Geranylgeranyltransferase Type-1 Subunit Alpha 2
  • Type I Protein Geranyl-Geranyltransferase Alpha Subunit 3
  • Type I Protein Geranyl-Geranyltransferase Subunit Alpha 4
  • Farnesyl-Protein Transferase Alpha-Subunit 3
  • CAAX Farnesyltransferase Subunit Alpha 4
  • EC 2.5.1.58 4
  • EC 2.5.1.59 4
  • PGGT1A 3
  • PTAR2 3
  • FPTA 3

External Ids for FNTA Gene

Previous GeneCards Identifiers for FNTA Gene

  • GC08P042647
  • GC08P042981
  • GC08P042928
  • GC08P041434

Summaries for FNTA Gene

Entrez Gene Summary for FNTA Gene

  • Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010]

GeneCards Summary for FNTA Gene

FNTA (Farnesyltransferase, CAAX Box, Alpha) is a Protein Coding gene. Among its related pathways are Terpenoid backbone biosynthesis and Apoptotic cleavage of cellular proteins. GO annotations related to this gene include microtubule binding and alpha-tubulin binding.

UniProtKB/Swiss-Prot for FNTA Gene

  • Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.

Tocris Summary for FNTA Gene

Gene Wiki entry for FNTA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNTA Gene

Genomics for FNTA Gene

Regulatory Elements for FNTA Gene

Enhancers for FNTA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FNTA on UCSC Golden Path with GeneCards custom track

Genomic Location for FNTA Gene

Chromosome:
8
Start:
43,034,194 bp from pter
End:
43,085,788 bp from pter
Size:
51,595 bases
Orientation:
Plus strand

Genomic View for FNTA Gene

Genes around FNTA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNTA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNTA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNTA Gene

Proteins for FNTA Gene

  • Protein details for FNTA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49354-FNTA_HUMAN
    Recommended name:
    Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
    Protein Accession:
    P49354
    Secondary Accessions:
    • A6NJW0
    • Q53XJ9
    • Q9UDC1

    Protein attributes for FNTA Gene

    Size:
    379 amino acids
    Molecular mass:
    44409 Da
    Quaternary structure:
    • Interacts with MUSK; the interaction is direct and mediates AGRIN-induced phosphorylation of FNTA (By similarity). Heterodimer of FNTA and FNTB (farnesyltransferase). Heterodimer of FNTA and PGGT1B (geranylgeranyltransferase).

    Three dimensional structures from OCA and Proteopedia for FNTA Gene

    Alternative splice isoforms for FNTA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FNTA Gene

Proteomics data for FNTA Gene at MOPED

Post-translational modifications for FNTA Gene

  • Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for FNTA Gene

Domains & Families for FNTA Gene

Protein Domains for FNTA Gene

Graphical View of Domain Structure for InterPro Entry

P49354

UniProtKB/Swiss-Prot:

FNTA_HUMAN :
  • Belongs to the protein prenyltransferase subunit alpha family.
  • Contains 5 PFTA repeats.
Family:
  • Belongs to the protein prenyltransferase subunit alpha family.
Similarity:
  • Contains 5 PFTA repeats.
genes like me logo Genes that share domains with FNTA: view

Function for FNTA Gene

Molecular function for FNTA Gene

GENATLAS Biochemistry:
CAAX farnesyltransferase,alpha subunit promoting the prenylation of Ras,first step of a series of post translational modification of RAS,required for its association with the inner surface of the plasma membrane,also involved in maturation of other proteins including Ras family members,the gamma subunit of G proteins and nuclear lamins
UniProtKB/Swiss-Prot CatalyticActivity:
Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by the AGRIN-induced phosphorylation which is mediated by MUSK.
UniProtKB/Swiss-Prot Function:
Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.

Enzyme Numbers (IUBMB) for FNTA Gene

Gene Ontology (GO) - Molecular Function for FNTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004660 contributes_to protein farnesyltransferase activity IDA 19228685
GO:0004661 protein geranylgeranyltransferase activity IDA 16893176
GO:0004662 contributes_to CAAX-protein geranylgeranyltransferase activity IBA --
genes like me logo Genes that share ontologies with FNTA: view
genes like me logo Genes that share phenotypes with FNTA: view

Animal Models for FNTA Gene

MGI Knock Outs for FNTA:
  • Fnta tm1b(KOMP)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for FNTA

miRNA for FNTA Gene

miRTarBase miRNAs that target FNTA

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FNTA Gene

Localization for FNTA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FNTA Gene COMPARTMENTS Subcellular localization image for FNTA gene
Compartment Confidence
cytosol 5
cytoskeleton 4
extracellular 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FNTA Gene

Pathways & Interactions for FNTA Gene

genes like me logo Genes that share pathways with FNTA: view

Gene Ontology (GO) - Biological Process for FNTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006921 cellular component disassembly involved in execution phase of apoptosis TAS --
GO:0007528 neuromuscular junction development IEA --
GO:0007603 phototransduction, visible light TAS --
GO:0012501 programmed cell death TAS --
GO:0071340 skeletal muscle acetylcholine-gated channel clustering IEA --
genes like me logo Genes that share ontologies with FNTA: view

No data available for SIGNOR curated interactions for FNTA Gene

Drugs & Compounds for FNTA Gene

(18) Drugs for FNTA Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
farnesyl diphosphate Experimental Pharma Antagonist, Target 0
(11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE Experimental Pharma Target 0
(20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE Experimental Pharma Target 0
(20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE Experimental Pharma Target 0
[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Experimental Pharma Target 0

(5) Additional Compounds for FNTA Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Geranylgeranyl-PP
  • 2-trans,6-trans,10-trans-Geranylgeranyl diphosphate
  • 3,7,11,15-Tetramethyl-2,6,10,14-hexadecatetraenyl diphosphate
  • All-trans-geranyl-geranyl-pp
  • Geranylgeranyl-diphosphate
  • Geranylgeranyl-PP
FTI 277
1217447-06-7
GGTI 297
GGTI 298
1217457-86-7
gliotoxin
67-99-2

(5) Tocris Compounds for FNTA Gene

Compound Action Cas Number
FTI 276 Farnesyltransferase (FTase) inhibitor; antitumor 1217471-51-6
FTI 277 Prodrug form of FTI 276 (Cat. No. 2406) 1217447-06-7
GGTI 297 Geranylgeranyltransferase I (GGTase I) inhibitor
GGTI 298 Geranylgeranyltransferase I (GGTase I) inhibitor 1217457-86-7
Gliotoxin Inhibitor of 20S proteasome; immunosuppressant 67-99-2

(1) ApexBio Compounds for FNTA Gene

Compound Action Cas Number
Tipifarnib (Zarnestra) Farnesyltransferase inhibitor,potent and specific 192185-72-1
genes like me logo Genes that share compounds with FNTA: view

Transcripts for FNTA Gene

Unigene Clusters for FNTA Gene

Farnesyltransferase, CAAX box, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FNTA Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b ^ 11
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: -
SP7: -
SP8:
SP9: - - - -

Relevant External Links for FNTA Gene

GeneLoc Exon Structure for
FNTA
ECgene alternative splicing isoforms for
FNTA

Expression for FNTA Gene

mRNA expression in normal human tissues for FNTA Gene

Protein differential expression in normal tissues from HIPED for FNTA Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FNTA Gene



SOURCE GeneReport for Unigene cluster for FNTA Gene Hs.370312

genes like me logo Genes that share expression patterns with FNTA: view

Protein tissue co-expression partners for FNTA Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FNTA Gene

Orthologs for FNTA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FNTA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FNTA 35
  • 89.78 (n)
  • 92.27 (a)
FNTA 36
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FNTA 35
  • 92.7 (n)
  • 94.99 (a)
-- 36
  • 94 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fnta 35
  • 87.98 (n)
  • 92.57 (a)
Fnta 16
Fnta 36
  • 93 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia FNTA 35
  • 99.56 (n)
  • 99.47 (a)
rat
(Rattus norvegicus)
Mammalia Fnta 35
  • 88.42 (n)
  • 92.84 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
OneToMany
chicken
(Gallus gallus)
Aves FNTA 35
  • 78.72 (n)
  • 88.99 (a)
-- 36
  • 82 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 79 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fnta 35
  • 74.06 (n)
  • 79.06 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12400 35
zebrafish
(Danio rerio)
Actinopterygii fnta 35
  • 66.77 (n)
  • 69.84 (a)
fnta 36
  • 60 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5468 35
fruit fly
(Drosophila melanogaster)
Insecta CG2976 37
  • 48 (a)
CG2976 35
  • 54.86 (n)
  • 50.16 (a)
CG2976 36
  • 46 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011767 35
  • 54.9 (n)
  • 52.61 (a)
worm
(Caenorhabditis elegans)
Secernentea R02D3.5 37
  • 40 (a)
fnta-1 35
  • 50 (n)
  • 41.28 (a)
fnta-1 36
  • 38 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR094C 35
  • 46.17 (n)
  • 37.56 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17975g 35
  • 47.45 (n)
  • 35.23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAM2 36
  • 28 (a)
OneToMany
RAM2 38
RAM2 35
  • 46.64 (n)
  • 31.92 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons FTA 35
  • 50.7 (n)
  • 45.1 (a)
rice
(Oryza sativa)
Liliopsida Os09g0514400 35
  • 51.85 (n)
  • 45.79 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03632 35
  • 45.29 (n)
  • 33.22 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cwp1 35
  • 50.37 (n)
  • 39.01 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2143 36
  • 58 (a)
OneToMany
Species with no ortholog for FNTA:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FNTA Gene

ENSEMBL:
Gene Tree for FNTA (if available)
TreeFam:
Gene Tree for FNTA (if available)

Paralogs for FNTA Gene

Pseudogenes.org Pseudogenes for FNTA Gene

genes like me logo Genes that share paralogs with FNTA: view

No data available for Paralogs for FNTA Gene

Variants for FNTA Gene

Sequence variations from dbSNP and Humsavar for FNTA Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2230266 -- 43,084,791(+) TCCCC(A/C)TACCT nc-transcript-variant, reference, synonymous-codon
rs7838899 -- 43,078,340(+) ttttt(G/T)tttgt intron-variant
rs3196850 -- 43,085,725(+) CTATC(A/C)CTGTA nc-transcript-variant, utr-variant-3-prime
rs10111452 -- 43,076,745(+) GGTGG(C/T)GCATG intron-variant
rs4236927 -- 43,082,465(+) TGTTT(C/T)CCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FNTA Gene

Variant ID Type Subtype PubMed ID
nsv890846 CNV Gain 21882294
nsv831302 CNV Loss 17160897
esv2547171 CNV Deletion 19546169
esv2235385 CNV Deletion 18987734
esv2668009 CNV Deletion 23128226
nsv470208 CNV Gain 18288195

Variation tolerance for FNTA Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FNTA Gene

HapMap Linkage Disequilibrium report
FNTA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNTA Gene

Disorders for FNTA Gene

Relevant External Links for FNTA

Genetic Association Database (GAD)
FNTA
Human Genome Epidemiology (HuGE) Navigator
FNTA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FNTA

No disorders were found for FNTA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FNTA Gene

Publications for FNTA Gene

  1. cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences. (PMID: 8276393) Andres D.A. … Francke U. (Genomics 1993) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  5. Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle. (PMID: 22160308) Ghavami S. … Halayko A.J. (Am. J. Physiol. Lung Cell Mol. Physiol. 2012) 3

Products for FNTA Gene

Sources for FNTA Gene

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