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Aliases for FNTA Gene

Aliases for FNTA Gene

  • Farnesyltransferase, CAAX Box, Alpha 2 3
  • Protein Prenyltransferase Alpha Subunit Repeat Containing 2 2 3
  • Ras Proteins Prenyltransferase Subunit Alpha 3 4
  • GGTase-I-Alpha 3 4
  • FTase-Alpha 3 4
  • Protein Farnesyltransferase/Geranylgeranyltransferase Type-1 Subunit Alpha 3
  • Type I Protein Geranyl-Geranyltransferase Alpha Subunit 3
  • Type I Protein Geranyl-Geranyltransferase Subunit Alpha 4
  • Farnesyl-Protein Transferase Alpha-Subunit 3
  • CAAX Farnesyltransferase Subunit Alpha 4
  • EC 2.5.1.58 4
  • EC 2.5.1.59 4
  • PGGT1A 3
  • PTAR2 3
  • FPTA 3

External Ids for FNTA Gene

Summaries for FNTA Gene

Entrez Gene Summary for FNTA Gene

  • Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010]

GeneCards Summary for FNTA Gene

FNTA (Farnesyltransferase, CAAX Box, Alpha) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include microtubule binding and protein farnesyltransferase activity. An important paralog of this gene is ENSG00000254673.

UniProtKB/Swiss-Prot for FNTA Gene

  • Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.

Tocris Summary for FNTA Gene

  • Prenyltransferases are enzymes which transfer prenyl groups to acceptor molecules. The family contains farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1), which attach a farnesyl group or a geranyl group respectively. This attachment permits membrane localization of proteins without a transmembrane domain, and occurs post-translationally. FTase and GGTase are heterodimeric enzymes, which both share an alpha-subunit and different beta-subunits. Both recognize a CAAX sequence present at the C-terminus of the target protein. Target proteins include Ras, which is suggestive of a role for prenylation in tumor development. Ras GTPases require farnesylation for malignant activity, and many of the downstream proteins it targets are also subject to farnesylation or geranylgeranylation in order to mediate the growth, survival and migration of tumor cells. Prenyltransferase inhibitors are therefore of interest in the development of cancer therapeutics. Farnesyltransferase inhibitors (FTIs) induce antitumor effects by inducing apoptosis and cell cycle arrest, and inhibiting cell proliferation, migration and angiogenesis. Geranylgeranyltransferase 1 inhibitors (GGTIs) also induce apoptosis and inhibit the growth of tumor cells.

Gene Wiki entry for FNTA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNTA Gene

Genomics for FNTA Gene

Genomic Location for FNTA Gene

Start:
43,034,194 bp from pter
End:
43,085,788 bp from pter
Size:
51,595 bases
Orientation:
Plus strand

Genomic View for FNTA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FNTA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNTA Gene

Regulatory Elements for FNTA Gene

Proteins for FNTA Gene

  • Protein details for FNTA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49354-FNTA_HUMAN
    Recommended name:
    Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
    Protein Accession:
    P49354
    Secondary Accessions:
    • A6NJW0
    • Q53XJ9
    • Q9UDC1

    Protein attributes for FNTA Gene

    Size:
    379 amino acids
    Molecular mass:
    44409 Da
    Quaternary structure:
    • Interacts with MUSK; the interaction is direct and mediates AGRIN-induced phosphorylation of FNTA (By similarity). Heterodimer of FNTA and FNTB (farnesyltransferase). Heterodimer of FNTA and PGGT1B (geranylgeranyltransferase).

    Three dimensional structures from OCA and Proteopedia for FNTA Gene

    Alternative splice isoforms for FNTA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FNTA Gene

Proteomics data for FNTA Gene at MOPED

Post-translational modifications for FNTA Gene

  • Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FNTA Gene

No data available for DME Specific Peptides for FNTA Gene

Domains for FNTA Gene

Gene Families for FNTA Gene

HGNC:
  • PTAR :Prenyltransferase alpha subunit repeat containing

Protein Domains for FNTA Gene

UniProtKB/Swiss-Prot:

FNTA_HUMAN
Family:
  • Belongs to the protein prenyltransferase subunit alpha family.:
    • P49354
Similarity:
  • Contains 5 PFTA repeats.:
    • P49354
genes like me logo Genes that share domains with FNTA: view

Function for FNTA Gene

Molecular function for FNTA Gene

GENATLAS Biochemistry: CAAX farnesyltransferase,alpha subunit promoting the prenylation of Ras,first step of a series of post translational modification of RAS,required for its association with the inner surface of the plasma membrane,also involved in maturation of other proteins including Ras family members,the gamma subunit of G proteins and nuclear lamins
UniProtKB/Swiss-Prot CatalyticActivity: Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate
UniProtKB/Swiss-Prot CatalyticActivity: Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by the AGRIN-induced phosphorylation which is mediated by MUSK.
UniProtKB/Swiss-Prot Function: Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.

Enzyme Numbers (IUBMB) for FNTA Gene

Gene Ontology (GO) - Molecular Function for FNTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004660 contributes_to protein farnesyltransferase activity IDA 19228685
GO:0004661 protein geranylgeranyltransferase activity IDA 16893176
GO:0004662 CAAX-protein geranylgeranyltransferase activity IEA --
GO:0004663 Rab geranylgeranyltransferase activity IEA --
GO:0005515 protein binding IPI 11687658
genes like me logo Genes that share ontologies with FNTA: view
genes like me logo Genes that share phenotypes with FNTA: view

miRNA for FNTA Gene

miRTarBase miRNAs that target FNTA

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for FNTA Gene

Localization for FNTA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FNTA Gene COMPARTMENTS Subcellular localization image for FNTA gene
Compartment Confidence
cytoskeleton 4
cytosol 4
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FNTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 8599089
GO:0005829 cytosol TAS --
GO:0005875 microtubule associated complex IDA 19228685
GO:0005953 CAAX-protein geranylgeranyltransferase complex IDA 16893176
GO:0005965 protein farnesyltransferase complex IDA 16893176
genes like me logo Genes that share ontologies with FNTA: view

Pathways for FNTA Gene

genes like me logo Genes that share pathways with FNTA: view

Gene Ontology (GO) - Biological Process for FNTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS --
GO:0006921 cellular component disassembly involved in execution phase of apoptosis TAS --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS 8599089
GO:0007603 phototransduction, visible light TAS --
GO:0010469 regulation of receptor activity IEA --
genes like me logo Genes that share ontologies with FNTA: view

Compounds for FNTA Gene

(3) Tocris Compounds for FNTA Gene

Compound Action Cas Number
FTI 276 Farnesyltransferase (FTase) inhibitor; antitumor [170006-72-1]
GGTI 297 Geranylgeranyltransferase I (GGTase I) inhibitor
LB 42708 Selective farnesyltransferase (FTase) inhibitor [226929-39-1]

(1) HMDB Compounds for FNTA Gene

Compound Synonyms Cas Number PubMed IDs
Farnesyl pyrophosphate
  • (2E,6E)-Farnesyl diphosphate
13058-04-3
genes like me logo Genes that share compounds with FNTA: view

Transcripts for FNTA Gene

Unigene Clusters for FNTA Gene

Farnesyltransferase, CAAX box, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FNTA Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b ^ 11
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: -
SP7: -
SP8:
SP9: - - - -

Relevant External Links for FNTA Gene

GeneLoc Exon Structure for
FNTA
ECgene alternative splicing isoforms for
FNTA

Expression for FNTA Gene

mRNA expression in normal human tissues for FNTA Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FNTA Gene

SOURCE GeneReport for Unigene cluster for FNTA Gene Hs.370312

genes like me logo Genes that share expressions with FNTA: view

Orthologs for FNTA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FNTA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FNTA 36
  • 99.56 (n)
  • 99.47 (a)
cow
(Bos Taurus)
Mammalia FNTA 36
  • 89.78 (n)
  • 92.27 (a)
FNTA 37
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 94 (a)
OneToMany
FNTA 36
  • 92.7 (n)
  • 94.99 (a)
mouse
(Mus musculus)
Mammalia Fnta 36
  • 87.98 (n)
  • 92.57 (a)
Fnta 16
Fnta 37
  • 93 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fnta 36
  • 88.42 (n)
  • 92.84 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 82 (a)
OneToMany
FNTA 36
  • 78.72 (n)
  • 88.99 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 79 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.12400 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fnta 36
  • 74.06 (n)
  • 79.06 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5468 36
zebrafish
(Danio rerio)
Actinopterygii fnta 36
  • 66.77 (n)
  • 69.84 (a)
fnta 37
  • 60 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011767 36
  • 54.9 (n)
  • 52.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2976 36
  • 54.86 (n)
  • 50.16 (a)
CG2976 37
  • 46 (a)
OneToMany
CG2976 38
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea fnta-1 36
  • 50 (n)
  • 41.28 (a)
fnta-1 37
  • 38 (a)
OneToMany
R02D3.5 38
  • 40 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR094C 36
  • 46.17 (n)
  • 37.56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAM2 36
  • 46.64 (n)
  • 31.92 (a)
RAM2 37
  • 28 (a)
OneToMany
RAM2 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17975g 36
  • 47.45 (n)
  • 35.23 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons FTA 36
  • 50.7 (n)
  • 45.1 (a)
rice
(Oryza sativa)
Liliopsida Os09g0514400 36
  • 51.85 (n)
  • 45.79 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03632 36
  • 45.29 (n)
  • 33.22 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cwp1 36
  • 50.37 (n)
  • 39.01 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2143 37
  • 58 (a)
OneToMany
Species with no ortholog for FNTA:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FNTA Gene

ENSEMBL:
Gene Tree for FNTA (if available)
TreeFam:
Gene Tree for FNTA (if available)

Paralogs for FNTA Gene

Paralogs for FNTA Gene

Pseudogenes.org Pseudogenes for FNTA Gene

genes like me logo Genes that share paralogs with FNTA: view

Variants for FNTA Gene

Sequence variations from dbSNP and Humsavar for FNTA Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1803597 -- 43,077,330(+) CTGGC(A/T)ACAAT missense, reference, nc-transcript-variant
rs2230266 -- 43,084,791(+) TCCCC(A/C)TACCT synonymous-codon, reference, nc-transcript-variant
rs3196850 -- 43,085,725(+) CTATC(A/C)CTGTA utr-variant-3-prime, nc-transcript-variant
rs4236927 -- 43,082,465(+) TGTTT(C/T)CCCAA intron-variant
rs4260929 -- 43,060,741(+) AAAGG(A/G)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FNTA Gene

Variant ID Type Subtype PubMed ID
nsv890846 CNV Gain 21882294
nsv831302 CNV Loss 17160897
esv2547171 CNV Deletion 19546169
esv2235385 CNV Deletion 18987734
esv2668009 CNV Deletion 23128226
nsv470208 CNV Gain 18288195

Relevant External Links for FNTA Gene

HapMap Linkage Disequilibrium report
FNTA

Disorders for FNTA Gene

(1) Novoseek inferred disease relationships for FNTA Gene

Disease -log(P) Hits PubMed IDs
hyperinsulinemia 49.7 1

Relevant External Links for FNTA

Genetic Association Database (GAD)
FNTA
Human Genome Epidemiology (HuGE) Navigator
FNTA
genes like me logo Genes that share disorders with FNTA: view

No data available for UniProtKB/Swiss-Prot for FNTA Gene

Publications for FNTA Gene

  1. cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences. (PMID: 8276393) Andres D.A. … Francke U. (Genomics 1993) 2 3 4
  2. Mutational analysis of alpha-subunit of protein farnesyltransferase. Evidence for a catalytic role. (PMID: 8419339) Andres D.A. … Brown M.S. (J. Biol. Chem. 1993) 3 4
  3. Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases. (PMID: 8494894) Omer C.A. … Kohl N.E. (Biochemistry 1993) 3 4
  4. Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents. (PMID: 12825937) deSolms S.J. … Taylor J.S. (J. Med. Chem. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for FNTA Gene

Sources for FNTA Gene

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