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FNTA Gene

protein-coding   GIFtS: 67
GCID: GC08P042928

Farnesyltransferase, CAAX Box, Alpha

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Farnesyltransferase, CAAX Box, Alpha1 2     Farnesyl-Protein Transferase Alpha-Subunit2
Protein Prenyltransferase Alpha Subunit Repeat Containing 21 2     Protein Farnesyltransferase/Geranylgeranyltransferase Type-1 Subunit Alpha2
Ras Proteins Prenyltransferase Subunit Alpha2 3     Type I Protein Geranyl-Geranyltransferase Alpha Subunit2
FTase-alpha2 3     EC 2.5.1.583
GGTase-I-alpha2 3     EC 2.5.1.593
FPTA2     CAAX Farnesyltransferase Subunit Alpha3
PGGT1A2     Type I Protein Geranyl-Geranyltransferase Subunit Alpha3
PTAR22     

External Ids:    HGNC: 37821   Entrez Gene: 23392   Ensembl: ENSG000001685227   OMIM: 1346355   UniProtKB: P493543   
ORGUL members:         

Export aliases for FNTA gene to outside databases

Previous GC identifers: GC08P042647 GC08P042981 GC08P043030 GC08P041434


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FNTA Gene:
Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the
cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX
farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This
gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript
variants. Related pseudogenes have been identified on chromosomes 11 and 13. (provided by RefSeq, May 2010)

GeneCards Summary for FNTA Gene:
FNTA (farnesyltransferase, CAAX box, alpha) is a protein-coding gene. Diseases associated with FNTA include hiv-1, and pancreatic cancer. GO annotations related to this gene include microtubule binding and protein farnesyltransferase activity. An important paralog of this gene is ENSG00000254673.

UniProtKB/Swiss-Prot: FNTA_HUMAN, P49354
Function: Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes
to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine
at the fourth position from the C-terminus of several proteins having the C-terminal sequence
Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its
function in RAC1 prenylation and activation

summary for FNTA Gene:
Prenyltransferases are enzymes which transfer prenyl groups to acceptor molecules. The family contains
farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1), which attach a farnesyl group or a geranyl
group respectively. This attachment permits membrane localization of proteins without a transmembrane
domain, and occurs post-translationally. FTase and GGTase are heterodimeric enzymes, which both share an
alpha-subunit and different beta-subunits. Both recognize a CAAX sequence present at the C-terminus of the
target protein. Target proteins include Ras, which is suggestive of a role for prenylation in tumor
development. Ras GTPases require farnesylation for malignant activity, and many of the downstream proteins
it targets are also subject to farnesylation or geranylgeranylation in order to mediate the growth, survival
and migration of tumor cells. Prenyltransferase inhibitors are therefore of interest in the development of
cancer therapeutics. Farnesyltransferase inhibitors (FTIs) induce antitumor effects by inducing apoptosis
and cell cycle arrest, and inhibiting cell proliferation, migration and angiogenesis.
Geranylgeranyltransferase 1 inhibitors (GGTIs) also induce apoptosis and inhibit the growth of tumor cells.

Gene Wiki entry for FNTA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_167187.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FNTA gene promoter:
         HOXA9B   HOXA9   AML1a   ATF-2   SREBP-1c   SREBP-1b   CRE-BP1   SREBP-1a   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFNTA promoter sequence
   Search Chromatin IP Primers for FNTA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FNTA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11   Ensembl cytogenetic band:  8p11.21   HGNC cytogenetic band: 8p11.21

FNTA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FNTA gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P042928:  view genomic region     (about GC identifiers)

Start:
42,889,337 bp from pter      End:
42,940,931 bp from pter
Size:
51,595 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FNTA_HUMAN, P49354 (See protein sequence)
Recommended Name: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha  
Size: 379 amino acids; 44409 Da
Subunit: Interacts with MUSK; the interaction is direct and mediates AGRIN-induced phosphorylation of FNTA (By
similarity). Heterodimer of FNTA and FNTB (farnesyltransferase). Heterodimer of FNTA and PGGT1B
(geranylgeranyltransferase)
Selected PDB 3D structures from and Proteopedia for FNTA (see all 14):
1JCQ (3D)        1LD7 (3D)        1LD8 (3D)        1MZC (3D)        1S63 (3D)        1SA4 (3D)    
Secondary accessions: A6NJW0 Q53XJ9 Q9UDC1
Alternative splicing: 2 isoforms:  P49354-1   P49354-2   

Explore the universe of human proteins at neXtProt for FNTA: NX_P49354

Explore proteomics data for FNTA at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA
    (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FNTA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002018.1  
    ENSEMBL proteins: 
     ENSP00000303423   ENSP00000437208   ENSP00000435455   ENSP00000432892   ENSP00000432411  
     ENSP00000436998   ENSP00000473479   ENSP00000434430   ENSP00000343931  
    Reactome Protein details: P49354

    FNTA Human Recombinant Protein Products:

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    Novus Biologicals FNTA Protein
    Novus Biologicals FNTA Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    FNTA Antibody Products:

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    FNTA Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PTAR: Prenyltransferase alpha subunit repeat containing

    1 InterPro protein domain:
     IPR002088 Prenyl_trans_a

    Graphical View of Domain Structure for InterPro Entry P49354

    ProtoNet protein and cluster: P49354

    1 Blocks protein domain: IPB002088 Protein prenyltransferase

    UniProtKB/Swiss-Prot: FNTA_HUMAN, P49354
    Similarity: Belongs to the protein prenyltransferase subunit alpha family
    Similarity: Contains 5 PFTA repeats


    FNTA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FNTA_HUMAN, P49354
    Function: Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes
    to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine
    at the fourth position from the C-terminus of several proteins having the C-terminal sequence
    Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its
    function in RAC1 prenylation and activation
    Catalytic activity: Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate
    Catalytic activity: Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate
    Enzyme regulation: Activated by the AGRIN-induced phosphorylation which is mediated by MUSK (By similarity)

         Genatlas biochemistry entry for FNTA:
    CAAX farnesyltransferase,alpha subunit promoting the prenylation of Ras,first step of a series of post
    translational modification of RAS,required for its association with the inner surface of the plasma membrane,also
    involved in maturation of other proteins including Ras family members,the gamma subunit of G proteins and nuclear
    lamins

         Enzyme Numbers (IUBMB): EC 2.5.1.591 EC 2.5.1.581

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004660contributes to protein farnesyltransferase activity IDA19228685
    GO:0004661protein geranylgeranyltransferase activity IDA16893176
    GO:0004662CAAX-protein geranylgeranyltransferase activity IEA--
    GO:0005515protein binding IPI11687658
    GO:0008017microtubule binding IDA19228685
         
    FNTA for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for FNTA:
     Decreased Tat-dependent transc  Decreased viability of wild-ty  Decreased viability with pacli  Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FNTA
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FNTA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FNTA

    miRNA
    Products:
        
    miRTarBase miRNAs that target FNTA:
    hsa-mir-16-5p (MIRT031435)

    Block miRNA regulation of human, mouse, rat FNTA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FNTA (see all 10):
    hsa-miR-15a hsa-miR-3065-3p hsa-miR-497 hsa-miR-578 hsa-miR-424 hsa-miR-590-3p hsa-miR-195 hsa-miR-16
    SwitchGear 3'UTR luciferase reporter plasmidFNTA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FNTA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FNTA

    Clone
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    OriGene clones in human, mouse for FNTA (see all 12)
    OriGene ORF clones in mouse, rat for FNTA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FNTA (NM_002027)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FNTA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNTA

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNTA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    nucleus2
    extracellular1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS8599089
    GO:0005829cytosol TAS--
    GO:0005875microtubule associated complex IDA19228685
    GO:0005953CAAX-protein geranylgeranyltransferase complex IDA16893176
    GO:0005965protein farnesyltransferase complex IDA16893176

    FNTA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FNTA About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1Apoptotic cleavage of cellular proteins
    Apoptotic cleavage of cellular proteins0.74
    Apoptotic execution phase0.74
    2The phototransduction cascade
    The phototransduction cascade0.51
    Inactivation, recovery and regulation of the phototransduction cascade0.49
    3Diseases associated with visual transduction
    Visual phototransduction0.44
    Diseases associated with visual transduction0.43
    4Signaling by GPCR
    Signal Transduction0.58
    5CDK-mediated phosphorylation and removal of Cdc6
    Apoptosis0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected GeneGo (Thomson Reuters) Pathways for FNTA (see all 10)
        G-protein signaling Regulation of RAC1 activity
    G-protein signaling H-RAS regulation pathway
    G-protein signaling Rac2 regulation pathway
    Cytoskeleton remodeling RalA regulation pathway
    G-protein signaling Rap1A regulation pathway

    1 BioSystems Pathway for FNTA
        TGF-beta Receptor Signaling Pathway

    2 Reactome Pathways for FNTA
        Apoptotic cleavage of cellular proteins
    Inactivation, recovery and regulation of the phototransduction cascade


    1 Kegg Pathway  (Kegg details for FNTA):
        Terpenoid backbone biosynthesis


    FNTA for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FNTA
    Interactions:

        GeneGlobe Interaction Network for FNTA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FNTA (P493541, 2, 3 ENSP000003034234) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FNTBP493561, 2, 3, ENSP000002461664EBI-602336,EBI-602349 MINT-24877 I2D: score=16 STRING: ENSP00000246166
    PTP4A3O753653, ENSP000003322744I2D: score=3 STRING: ENSP00000332274
    ACVR1Q047713, ENSP000002636404I2D: score=2 STRING: ENSP00000263640
    GBP1P324553, ENSP000003595044I2D: score=2 STRING: ENSP00000359504
    HRASP011123, ENSP000003098454I2D: score=2 STRING: ENSP00000309845
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0007179transforming growth factor beta receptor signaling pathway TAS8599089
    GO:0007603phototransduction, visible light TAS--
    GO:0016056rhodopsin mediated signaling pathway TAS--

    FNTA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Compounds for FNTA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FTI 276Farnesyltransferase (FTase) inhibitor; antitumor[170006-72-1]
    GGTI 297Geranylgeranyltransferase I (GGTase I) inhibitor--
    LB 42708Selective farnesyltransferase (FTase) inhibitor[226929-39-1]

    1 HMDB Compound for FNTA    About this table
    CompoundSynonyms CAS #PubMed Ids
    Farnesyl pyrophosphate(2E,6E)-Farnesyl diphosphate (see all 15)13058-04-3--

    Selected DrugBank Compounds for FNTA (see all 11)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE-- --target--10592235
    (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE-- --target--10592235
    (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE-- --target--10592235
    2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE-- --target--10592235
    2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE-- --target--10592235
    4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE-- --target--10592235
    ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID-- --target--10592235
    FARNESYL-- --target--10592235
    FARNESYL DIPHOSPHATE-- --target--10592235
    GERANYLGERANYL DIPHOSPHATE-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FNTA gene (3 alternative transcripts): 
    NM_002027.2  NM_001018676.1  NM_001018677.1  

    Unigene Cluster for FNTA:

    Farnesyltransferase, CAAX box, alpha
    Hs.370312  [show with all ESTs]
    Unigene Representative Sequence: AK123002
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533559 ENST00000302279(uc003xps.3 uc003xpt.3) ENST00000526755(uc003xpv.3)
    ENST00000527153 ENST00000533383 ENST00000533998 ENST00000524546 ENST00000531266
    ENST00000533368 ENST00000525699 ENST00000529687 ENST00000533336 ENST00000525099
    ENST00000528400 ENST00000342116
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FNTA (see all 10):
    hsa-miR-15a hsa-miR-3065-3p hsa-miR-497 hsa-miR-578 hsa-miR-424 hsa-miR-590-3p hsa-miR-195 hsa-miR-16
    SwitchGear 3'UTR luciferase reporter plasmidFNTA 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: FNTA (NM_002027)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FNTA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNTA
    Primer
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    OriGene qPCR primer pairs and template standards for FNTA
    OriGene qSTAR qPCR primer pairs in human, mouse for FNTA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FNTA
      QuantiTect SYBR Green Assays in human, mouse, rat FNTA
      QuantiFast Probe-based Assays in human, mouse, rat FNTA

    Additional mRNA sequence: 

    AK123002.1 AK292121.1 BC017029.2 BC084566.1 BT009854.1 L00634.1 L10413.1 NR_033698.1 

    19 DOTS entries:

    DT.100821438  DT.100821416  DT.100821431  DT.75157943  DT.91757762  DT.100662438  DT.100771199  DT.100821440 
    DT.75139970  DT.209183  DT.91757767  DT.100821428  DT.100638709  DT.120641580  DT.418840  DT.91757754 
    DT.91757760  DT.95316831  DT.97779929 

    Selected AceView cDNA sequences (see all 417):

    AI005190 BP343285 BM765819 CR619812 AA548757 BU618041 AA961494 CR613348 
    CR609319 CA391192 BF061401 AU119741 AW613291 BE796707 L10413 CR604891 
    CB158228 BU070516 NM_002027 AI538078 AU118140 CR590542 CF264756 BQ057038 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FNTA (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b ^ 11
    SP1:                                -                       -                       -     -     -                           
    SP2:                                -     -                 -                       -     -     -                           
    SP3:                                                        -                       -     -     -                           
    SP4:                                -                       -     -                                                         
    SP5:                                -     -     -           -     -                 -     -     -                           


    ECgene alternative splicing isoforms for FNTA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FNTA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGTCAAGATT
    FNTA Expression
    About this image

    FNTA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FNTA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.370312
        Custom PCR Arrays for FNTA
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FNTA gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fnta1 , 5 farnesyltransferase, CAAX box, alpha1, 5 87.98(n)1
    92.57(a)1
      8 (14.27 cM)5
    142721  NM_008033.31  NP_032059.11 
     259987295 
    chicken
    (Gallus gallus)
    Aves FNTA1 farnesyltransferase, CAAX box, alpha 78.72(n)
    88.99(a)
      427299  XM_424881.4  XP_424881.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    79(a)
    1 → many
    GL343339.1(1113128-1131234)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.124002 Xenopus laevis transcribed sequence with moderate similarity more 78.37(n)    CD099712.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fnta1 farnesyltransferase, CAAX box, alpha 66.77(n)
    69.84(a)
      555882  NM_001080560.2  NP_001074029.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG29761 , 3 protein farnesyltransferase3
    CG29761
    48(a)3
    54.86(n)1
    50.16(a)1
      25A83
    336821  NM_001273119.11  NP_001260048.11 
    worm
    (Caenorhabditis elegans)
    Secernentea R02D3.53
    fnta-11
    farnesyltransferase alpha subunit3
    fnta-11
    40(a)3
    50(n)1
    41.28(a)1
      IV(237962-240298)3
    1768401  NM_067481.51  NP_499882.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAM2(YKL019W)4
    RAM21
    Alpha subunit of both the farnesyltransferase and type more4
    RAM21
    46.64(n)1
    31.92(a)1
      11(402568-403518)4
    8538491, 4  NP_012906.31  NP_012906.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons FTA1 FTA 50.7(n)
    45.1(a)
      825107  NM_115800.5  NP_567084.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g05144001 Os09g0514400 51.85(n)
    45.79(a)
      4347566  NM_001070194.1  NP_001063659.1 


    ENSEMBL Gene Tree for FNTA (if available)
    TreeFam Gene Tree for FNTA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FNTA gene
    ENSG000002546732  

    FNTA for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for FNTA
    PGOHUM00000242832 PGOHUM00000248522


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FNTA (see all 615)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1443536461,2
    --42909549(+) TTTTCC/TTCTGT 2 -- us2k10--------
    rs1461266011,2
    C--42909716(+) TAATAC/TTATAC 2 -- us2k10--------
    rs1868306741,2
    --42909774(+) AGAAAC/TTCAAC 2 -- us2k10--------
    rs736291031,2
    C,F--42909838(+) AGTGGA/GAGAGG 2 -- us2k13Minor allele frequency- G:0.05WA NA 240
    rs1400600721,2
    --42909919(+) TTAGAA/GTAGTA 2 -- us2k10--------
    rs1423637351,2
    --42910150(+) GACCCA/GTTGTT 2 -- us2k10--------
    rs1512424491,2
    --42910205(+) CTGAGC/TCAAAT 2 -- us2k10--------
    rs1912952961,2
    --42910311(+) GAGGCA/GTAAGA 2 -- us2k10--------
    rs1392717811,2
    --42910339(+) TAAGAA/TACACA 2 -- us2k10--------
    rs1117279941,2
    C,F--42910467(+) TCCAGG/ATTGTG 2 -- us2k12Minor allele frequency- A:0.03NA 122

    HapMap Linkage Disequilibrium report for FNTA (42889337 - 42940931 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for FNTA:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2235385CNV Deletion18987734
    esv2547171CNV Deletion19546169
    esv2668009CNV Deletion23128226
    nsv831302CNV Loss17160897
    nsv470208CNV Gain18288195
    nsv890846CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 134635    OMIM disorders: --

    6 diseases for FNTA:    
    About MalaCards
    hiv-1    pancreatic cancer    pancreatitis    colorectal cancer
    malaria    endotheliitis


    FNTA for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for FNTA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperinsulinemia 49.7 1 9920764 (1)

    Genetic Association Database (GAD): FNTA
    Human Genome Epidemiology (HuGE) Navigator: FNTA (2 documents)

    Export disorders for FNTA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FNTA gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with FNTA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences. (PubMed id 8276393)1, 2, 3 Andres D.A.... Francke U. (Genomics 1993)
    2. Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study. (PubMed id 19841875)1, 4 Fontaine-Bisson B....Morange P.E. (J. Mol. Med. 2010)
    3. Conversion of protein farnesyltransferase to a geranylgeranyltransferase. (PubMed id 16893176)1, 2 Terry K.L.... Beese L.S. (Biochemistry 2006)
    4. Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity. (PubMed id 15170324)1, 2 Reid T.S. and Beese L.S. (Biochemistry 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. (PubMed id 15451670)1, 2 Reid T.S....Beese L.S. (J. Mol. Biol. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents. (PubMed id 12825937)1, 2 deSolms S.J.... Taylor J.S. (J. Med. Chem. 2003)
    9. 3-aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency. (PubMed id 12036349)1, 2 Bell I.M.... Zartman C.B. (J. Med. Chem. 2002)
    10. The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. (PubMed id 11687658)1, 2 Long S.B.... Beese L.S. (Proc. Natl. Acad. Sci. U.S.A. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2339 HGNC: 3782 AceView: FNTA Ensembl:ENSG00000168522 euGenes: HUgn2339
    ECgene: FNTA Kegg: 2339 H-InvDB: FNTA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FNTA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FNTA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FNTA gene:
    Search GeneIP for patents involving FNTA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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