FNTA Gene
protein-coding GIFtS: 66
GCID: GC08P042928
|
|
farnesyltransferase, CAAX box, alpha
| |
Aliases
for FNTA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Farnesyltransferase, CAAX Box, Alpha1 2 | | Protein Farnesyltransferase/Geranylgeranyltransferase Type-1 Subunit Alpha2 | | FPTA1 2 | | Protein Prenyltransferase Alpha Subunit Repeat Containing 22 | | PGGT1A1 2 | | Type I Protein Geranyl-Geranyltransferase Alpha Subunit2 | | PTAR21 2 | | EC 2.5.1.583 | | Ras Proteins Prenyltransferase Subunit Alpha2 3 | | EC 2.5.1.593 | | FTase-Alpha1 | | CAAX Farnesyltransferase Subunit Alpha3 | | GGTase-I-Alpha1 | | Type I Protein Geranyl-Geranyltransferase Subunit Alpha3 | | Farnesyl-Protein Transferase Alpha-Subunit2 | | |
| External Ids: | HGNC: 37821 | Entrez Gene: 23392 | Ensembl: ENSG000001685227 | OMIM: 1346355 | UniProtKB: P493543 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n409338 | |
Export aliases for FNTA gene to outside databasesPrevious GC identifers: GC08P042647 GC08P042981 GC08P043030 GC08P041434
Summaries
for FNTA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FNTA:
Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteineresidue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase areheterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunitof these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have beenidentified on chromosomes 11 and 13. (provided by RefSeq, May 2010)
UniProtKB/Swiss-Prot: FNTA_HUMAN, P49354Function: Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphateto a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequenceCys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. Thebeta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulateneuromuscular junction development downstream of MUSK (By similarity)
 summary
for FNTA: Prenyltransferases are enzymes which transfer prenyl groups to acceptor molecules. The family contains
farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1), which attach a farnesyl group or a geranyl
group respectively. This attachment permits membrane localization of proteins without a transmembrane
domain, and occurs post-translationally. FTase and GGTase are heterodimeric enzymes, which both share an
alpha-subunit and different beta-subunits. Both recognize a CAAX sequence present at the C-terminus of the
target protein. Target proteins include Ras, which is suggestive of a role for prenylation in tumor
development. Ras GTPases require farnesylation for malignant activity, and many of the downstream proteins
it targets are also subject to farnesylation or geranylgeranylation in order to mediate the growth, survival
and migration of tumor cells. Prenyltransferase inhibitors are therefore of interest in the development of
cancer therapeutics. Farnesyltransferase inhibitors (FTIs) induce antitumor effects by inducing apoptosis
and cell cycle arrest, and inhibiting cell proliferation, migration and angiogenesis.
Geranylgeranyltransferase 1 inhibitors (GGTIs) also induce apoptosis and inhibit the growth of tumor cells.
Gene Wiki entry for FNTA
|
Genomic Views
for FNTA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FNTA gene promoter:
HOXA9B HOXA9 AML1a ATF-2 SREBP-1c SREBP-1b CRE-BP1 SREBP-1a Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FNTA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FNTA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p11 Ensembl cytogenetic band: 8p11.21 HGNC cytogenetic band: 8p11.21FNTA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P042928: view genomic region
(about GC identifiers)
Start:
|
42,889,337 bp from pter |
End:
|
42,940,931 bp from pter |
Size:
|
51,595 bases |
Orientation:
|
plus strand |
|
Proteins
for FNTA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FNTA_HUMAN, P49354 (See
protein sequence)Recommended Name: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Size: 379 amino acids; 44409 Da
Subunit: Heterodimer of an alpha and a beta subunit. Interacts with MUSK; the interaction is direct and mediatesAGRIN-induced phosphorylation of FNTA (By similarity)
6/14 PDB 3D structures from  and Proteopedia  for FNTA (see all 14):1JCQ (3D)
1LD7 (3D)
1LD8 (3D)
1MZC (3D)
1S63 (3D)
1SA4 (3D)
Secondary accessions: A6NJW0 Q53XJ9 Q9UDC1Alternative splicing: 2 isoforms: P49354-1 P49354-2 Explore the universe of human proteins at neXtProt for FNTA: NX_P49354
Post-translational modifications:
Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA (Bysimilarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P49354
FNTA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002018.1
ENSEMBL proteins: ENSP00000303423 ENSP00000437208 ENSP00000435455 ENSP00000432892 ENSP00000432411 ENSP00000436998 ENSP00000434430 ENSP00000343931 Reactome Protein details: P49354
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
FNTA for ontologies About GeneDecksing
FNTA Antibody Products:
Assay Products for FNTA: |
Protein
Domains /
Families
for FNTA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FNTA for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P49354ProtoNet protein and cluster: P49354 1 Blocks protein family: IPB002088 Protein prenyltransferase
UniProtKB/Swiss-Prot: FNTA_HUMAN, P49354Similarity: Belongs to the protein prenyltransferase subunit alpha familySimilarity: Contains 5 PFTA repeats |
Function
for FNTA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FNTA_HUMAN, P49354Function: Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphateto a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequenceCys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. Thebeta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulateneuromuscular junction development downstream of MUSK (By similarity)Catalytic activity: Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphateCatalytic activity: Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphateEnzyme regulation: Activated by the AGRIN-induced phosphorylation which is mediated by MUSK (By similarity) Genatlas biochemistry entry for FNTA:CAAX farnesyltransferase,alpha subunit promoting the prenylation of Ras,first step of a series of post translationalmodification of RAS,required for its association with the inner surface of the plasma membrane,also involved inmaturation of other proteins including Ras family members,the gamma subunit of G proteins and nuclear lamins
Enzyme Numbers (IUBMB): EC 2.5.1.591 EC 2.5.1.581
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNTA (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNTA (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FNTA (NM_002027) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FNTA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNTA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNTA |
Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table
FNTA for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for FNTA:
|
Pathways & Interactions
for FNTA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | G-protein signaling_RhoA regulation pathway | | | 2 | G-protein signaling K-RAS regulation pathway | | | 3 | G-protein signaling Rap1A regulation pathway | | | 4 | G-protein signaling Regulation of RAC1 activity | | | 5 | Apoptotic cleavage of cellular proteins | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/10 EMD Millipore Pathways for FNTA (see all 10)
5/10  GeneGo (Thomson Reuters) Pathways for FNTA (see all 10)
1  BioSystems Pathway for FNTA
3 
Reactome Pathways for FNTA
FNTA for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FNTA
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
5/29 Interacting proteins for FNTA (P493541, 2, 3 ENSP000003034234) via UniProtKB, MINT, STRING, and/or I2D (see all 29)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
FNTA for ontologies About GeneDecksing
|
Drugs & Compounds
for FNTA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for FNTA available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Gliotoxin | Immunosuppressant; inhibits NF-kappaB and cytokine production | [67-99-2] | | FTI 276 | Farnesyltransferase (Ftase) inhibitor | [170006-72-1] | | LB 42708 | Selective farnesyltransferase (FTase) inhibitor | [226929-39-1] |
1 HMDB Compound for FNTA About this table
10/11 DrugBank Compounds for FNTA (see all 11) About this table
| Compound | Synonyms |
CAS
# | Type | Actions | PubMed Ids |
|---|
| (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE | -- | -- | target | -- | 10592235 | | (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE | -- | -- | target | -- | 10592235 | | (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE | -- | -- | target | -- | 10592235 | | 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE | -- | -- | target | -- | 10592235 | | 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE | -- | -- | target | -- | 10592235 | | 4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE | -- | -- | target | -- | 10592235 | | ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID | -- | -- | target | -- | 10592235 | | FARNESYL | -- | -- | target | -- | 10592235 | | FARNESYL DIPHOSPHATE | -- | -- | target | -- | 10592235 | | GERANYLGERANYL DIPHOSPHATE | -- | -- | target | -- | 10592235 |
Search CenterWatch for drugs/clinical trials and news about FNTA
|
Transcripts
for FNTA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FNTA gene (3 alternative transcripts): NM_002027.2 NM_001018676.1 NM_001018677.1 Unigene Cluster for FNTA: Farnesyltransferase, CAAX box, alpha Hs.370312 [show with all ESTs]Unigene Representative Sequence: AK12300215 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000533559 ENST00000302279(uc003xps.3 uc003xpt.3) ENST00000526755(uc003xpv.3)
ENST00000527153 ENST00000533383 ENST00000533998 ENST00000524546 ENST00000531266
ENST00000533368 ENST00000525699 ENST00000529687 ENST00000533336 ENST00000525099
ENST00000528400 ENST00000342116
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNTA (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNTA (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FNTA (NM_002027) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FNTA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNTA |
Additional cDNA sequence: AK123002.1 AK292121.1 BC017029.2 BC084566.1 BT009854.1 L00634.1 L10413.1 NR_033698.1 19 DOTS entries: DT.100821438 DT.100821416 DT.75157943 DT.100821431 DT.91757762 DT.100662438 DT.100771199 DT.100821440 DT.75139970 DT.209183 DT.91757767 DT.100821428 DT.100638709 DT.120641580 DT.418840 DT.91757754 DT.91757760 DT.95316831 DT.97779929 24/417 AceView cDNA sequences (see all 417): AW613291 W47648 CA391192 BM673108 L10413 AI131520 BF727087 BC017029 BQ440215 BQ954652 AA769526 AI283336 BE796707 BG168896 BM765819 AI674250 BF447167 W19473 CR597451 CF264756 CB158228 BE267191 AA431202 AI718283
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for FNTA (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | - | | | | | | | | - | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | - | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | | | - | | - | | | | | | - | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for FNTA
|
Expression
for FNTA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FNTA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGTCAAGATT
About this image
See FNTA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FNTA
SOURCE GeneReport for Unigene cluster: Hs.370312
SABiosciences Custom PCR Arrays for FNTA
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FNTA
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FNTA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FNTA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FNTA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNTA |
Orthologs
for FNTA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for FNTA gene from 10/33 species (see all 33) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Fnta1 , 5 |
farnesyltransferase, CAAX box, alpha1, 5 |
87.98(n)1
92.57(a)1 |
|
8 (14.27 cM)5
142721 NM_008033.31 NP_032059.11
259987295 |
chicken
(Gallus gallus) |
Aves |
FNTA1 |
farnesyltransferase, CAAX box, alpha |
77.25(n)
85.88(a) |
|
427299 XM_424881.3 XP_424881.3 |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
83(a) |
1 → many |
GL343339.1(1113936-1127509) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.124002 |
Xenopus laevis transcribed sequence with moderate similarity more |
78.37(n) |
|
CD099712.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
fnta1 |
farnesyltransferase, CAAX box, alpha |
66.16(n)
68.1(a) |
|
555882 NM_001080560.2 NP_001074029.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG29761 , 3 |
protein farnesyltransferase3
CG29761 |
48(a)3
55.7(n)1
50.16(a)1 |
|
25A83
336821 NM_135018.21 NP_608862.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
R02D3.53
fnta-11 |
farnesyltransferase alpha subunit3
Protein FNTA-11 |
40(a)3
49.89(n)1
41.28(a)1 |
|
IV(237962-240298)3
1768401 NM_067481.41 NP_499882.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
RAM2(YKL019W)4
RAM21 |
Alpha subunit of both the farnesyltransferase and type more4
Ram2p1 |
45.36(n)1
30(a)1 |
|
11(402568-403518)4
8538491, 4 NP_012906.31 NP_012906.14 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
FTA1 |
farnesyltransferase A |
50.29(n)
45.3(a) |
|
825107 NM_115800.5 NP_567084.1 |
rice
(Oryza sativa) |
Liliopsida |
Os09g05144001 |
hypothetical protein |
51.96(n)
46.46(a) |
|
4347566 NM_001070194.1 NP_001063659.1 |
ENSEMBL Gene Tree for FNTA (if available)
TreeFam Gene Tree for FNTA (if available) |
Paralogs
for FNTA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FNTA gene
- ENSG000002546732
FNTA for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for FNTA
PGOHUM00000242832 PGOHUM00000248522
|
Genomic Variants
for FNTA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FNTA (42889337 - 42940931 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for FNTA
3 CNVs: 29790 44347 100330 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FNTA |
|
Disorders
/ Diseases
for FNTA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FNTA for disorders About GeneDecksing
OMIM gene information: 134635
OMIM disorders: --
4  diseases for FNTA: About MalaCardscolorectal cancer malaria pancreatic cancer pancreatitis
1 Novoseek disease relationship for FNTA gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hyperinsulinemia |
49.7 |
1 |
9920764 (1) |
Human Genome Epidemiology (HuGE) Navigator: FNTA (2 documents)
Export disorders for FNTA gene to outside databases
|
Publications
for FNTA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FNTA gene, integrated from 9 sources (see all 53):
(articles sorted by number of sources associating them with FNTA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences. (PubMed id 8276393)1, 2, 3 Andres D.A.... Francke U. (1993)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents. (PubMed id 12825937)1, 2 deSolms S.J.... Taylor J.S. (2003)
- 3-aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency. (PubMed id 12036349)1, 2 Bell I.M.... Zartman C.B. (2002)
- The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. (PubMed id 11687658)1, 2 Long S.B.... Beese L.S. (2001)
- Mutational analysis of alpha-subunit of protein farnesyltransferase. Evidence for a catalytic role. (PubMed id 8419339)1, 2 Andres D.A.... Brown M.S. (1993)
- Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases. (PubMed id 8494894)1, 2 Omer C.A.... Kohl N.E. (1993)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Geranylgeranyl transferase 1 modulates autophagy and a poptosis in human airway smooth muscle. (PubMed id 22160308)1 Ghavami S....Halayko A.J. (2012)
|
External Searches for FNTA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FNTA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FNTA gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FNTA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for FNTA gene:
Search GeneIP for patents involving FNTA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FNTA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for FNTA | | OriGene shRNA RFP for FNTA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FNTA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FNTA | | | OriGene Protein Over-expression Lysate for FNTA | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FNTA | | OriGene 3'-UTR Clone for FNTA | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNTA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNTA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FNTA | | OriGene Custom Protein Services for FNTA | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FNTA | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FNTA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FNTA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FNTA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FNTA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FNTA |
| |
 |  |  |  | |
| | | | Tocris compounds for FNTA |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNTA |
|  |  |  | | | | ThermoFisher Antibodies for FNTA |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNTA |
|
|
|
|
GeneCards Homepage -
Last full update: 18 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
View Random Gene
|
Category
|
|
|
von Willebrand factor
|
| GIFtS Group |
|
Developed at the Crown Human Genome Center,
Department of Molecular Genetics,
the Weizmann Institute of Science
Copyright © 1996-2013
, Weizmann Institute of Science. All Rights Reserved.
hostname: 356977-web1.xennexinc.com
index build: 100 solr: 1.4
|
