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Aliases for FNTA Gene

Aliases for FNTA Gene

  • Farnesyltransferase, CAAX Box, Alpha 2 3 5
  • Protein Farnesyltransferase/Geranylgeranyltransferase Type-1 Subunit Alpha 2 3
  • Protein Prenyltransferase Alpha Subunit Repeat Containing 2 2 3
  • Ras Proteins Prenyltransferase Subunit Alpha 3 4
  • GGTase-I-Alpha 3 4
  • FTase-Alpha 3 4
  • Type I Protein Geranyl-Geranyltransferase Alpha Subunit 3
  • Type I Protein Geranyl-Geranyltransferase Subunit Alpha 4
  • Farnesyl-Protein Transferase Alpha-Subunit 3
  • CAAX Farnesyltransferase Subunit Alpha 4
  • EC 2.5.1.58 4
  • EC 2.5.1.59 4
  • PGGT1A 3
  • PTAR2 3
  • FPTA 3

External Ids for FNTA Gene

Previous GeneCards Identifiers for FNTA Gene

  • GC08P042647
  • GC08P042981
  • GC08P042928
  • GC08P041434

Summaries for FNTA Gene

Entrez Gene Summary for FNTA Gene

  • Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010]

GeneCards Summary for FNTA Gene

FNTA (Farnesyltransferase, CAAX Box, Alpha) is a Protein Coding gene. Among its related pathways are Metabolism of fat-soluble vitamins and G-protein signaling_Rap2B regulation pathway. GO annotations related to this gene include microtubule binding and alpha-tubulin binding.

UniProtKB/Swiss-Prot for FNTA Gene

  • Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.

Tocris Summary for FNTA Gene

Gene Wiki entry for FNTA Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNTA Gene

Genomics for FNTA Gene

Regulatory Elements for FNTA Gene

Enhancers for FNTA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G042841 1.1 ENCODE 10.3 -191.3 -191314 3.5 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 HOOK3 RNF170 FNTA THAP1 CHRNA6
GH08G042856 0.9 Ensembl ENCODE 10.4 -177.0 -177001 1.8 ZBED1 JUN JUNB GABPA ARID3A JUND CBX5 IKZF1 TCF7 ETV6 HOOK3 RNF170 FNTA THAP1 RN7SL806P
GH08G042893 1.4 FANTOM5 ENCODE 6.2 -138.2 -138249 5.9 HDGF PKNOX1 FOXA2 AGO1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 THAP1 HOOK3 FNTA MIR4469 PIR47842
GH08G043054 1.2 ENCODE 6.2 +22.3 22342 4.0 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 MEF2D HOOK3 IKBKB ENSG00000254673 ENSG00000254198 HGSNAT RNF170 POMK THAP1 FNTA GC08P043074
GH08G043139 1.1 ENCODE 6.2 +106.7 106687 3.7 PKNOX1 ARNT CREB3L1 AGO1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 FOS FNTA HOOK3 HGSNAT RNY5P6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FNTA on UCSC Golden Path with GeneCards custom track

Genomic Location for FNTA Gene

Chromosome:
8
Start:
43,034,194 bp from pter
End:
43,085,788 bp from pter
Size:
51,595 bases
Orientation:
Plus strand

Genomic View for FNTA Gene

Genes around FNTA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNTA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNTA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNTA Gene

Proteins for FNTA Gene

  • Protein details for FNTA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49354-FNTA_HUMAN
    Recommended name:
    Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
    Protein Accession:
    P49354
    Secondary Accessions:
    • A6NJW0
    • Q53XJ9
    • Q9UDC1

    Protein attributes for FNTA Gene

    Size:
    379 amino acids
    Molecular mass:
    44409 Da
    Quaternary structure:
    • Interacts with MUSK; the interaction is direct and mediates AGRIN-induced phosphorylation of FNTA (By similarity). Heterodimer of FNTA and FNTB (farnesyltransferase). Heterodimer of FNTA and PGGT1B (geranylgeranyltransferase).

    Three dimensional structures from OCA and Proteopedia for FNTA Gene

    Alternative splice isoforms for FNTA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FNTA Gene

Post-translational modifications for FNTA Gene

  • Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FNTA Gene

Domains & Families for FNTA Gene

Protein Domains for FNTA Gene

Graphical View of Domain Structure for InterPro Entry

P49354

UniProtKB/Swiss-Prot:

FNTA_HUMAN :
  • Belongs to the protein prenyltransferase subunit alpha family.
Family:
  • Belongs to the protein prenyltransferase subunit alpha family.
genes like me logo Genes that share domains with FNTA: view

Function for FNTA Gene

Molecular function for FNTA Gene

GENATLAS Biochemistry:
CAAX farnesyltransferase,alpha subunit promoting the prenylation of Ras,first step of a series of post translational modification of RAS,required for its association with the inner surface of the plasma membrane,also involved in maturation of other proteins including Ras family members,the gamma subunit of G proteins and nuclear lamins
UniProtKB/Swiss-Prot CatalyticActivity:
Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by the AGRIN-induced phosphorylation which is mediated by MUSK.
UniProtKB/Swiss-Prot Function:
Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.

Enzyme Numbers (IUBMB) for FNTA Gene

Gene Ontology (GO) - Molecular Function for FNTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004660 contributes_to protein farnesyltransferase activity IDA,TAS 19228685
GO:0004661 protein geranylgeranyltransferase activity IDA,TAS 16893176
GO:0004662 CAAX-protein geranylgeranyltransferase activity IEA --
GO:0004663 Rab geranylgeranyltransferase activity IEA --
GO:0005515 protein binding IPI 11687658
genes like me logo Genes that share ontologies with FNTA: view
genes like me logo Genes that share phenotypes with FNTA: view

Animal Models for FNTA Gene

MGI Knock Outs for FNTA:
  • Fnta tm1b(KOMP)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for FNTA

CRISPR Products

miRNA for FNTA Gene

miRTarBase miRNAs that target FNTA

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FNTA
  • Applied Biological Materials Clones for FNTA

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FNTA Gene

Localization for FNTA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FNTA gene
Compartment Confidence
cytosol 5
cytoskeleton 4
plasma membrane 2
extracellular 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for FNTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 8599089
GO:0005829 cytosol TAS --
GO:0005875 microtubule associated complex IDA 19228685
GO:0005886 plasma membrane IEA --
GO:0005953 CAAX-protein geranylgeranyltransferase complex IDA 16893176
genes like me logo Genes that share ontologies with FNTA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FNTA Gene

Pathways & Interactions for FNTA Gene

genes like me logo Genes that share pathways with FNTA: view

Gene Ontology (GO) - Biological Process for FNTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007179 transforming growth factor beta receptor signaling pathway TAS 8599089
GO:0007528 neuromuscular junction development IEA --
GO:0018342 protein prenylation IEA --
GO:0018343 protein farnesylation TAS,IDA 16893176
GO:0018344 protein geranylgeranylation IDA,TAS 16893176
genes like me logo Genes that share ontologies with FNTA: view

No data available for SIGNOR curated interactions for FNTA Gene

Drugs & Compounds for FNTA Gene

(18) Drugs for FNTA Gene - From: DrugBank, ApexBio, DGIdb, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE Experimental Pharma Target 0
(20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE Experimental Pharma Target 0
(20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE Experimental Pharma Target 0
[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Experimental Pharma Target 0
2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE Experimental Pharma Target 0

(4) Additional Compounds for FNTA Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Farnesyl pyrophosphate
  • (2E,6E)-Farnesyl diphosphate
  • (2E,6E)-Farnesyl pyrophosphate
  • (all-E)-Farnesyl diphosphate
  • (E,E)-Farnesyl diphosphate
  • (E,E)-Farnesyl pyrophosphate
13058-04-3
Geranylgeranyl-PP
  • 2-trans,6-trans,10-trans-Geranylgeranyl diphosphate
  • 3,7,11,15-Tetramethyl-2,6,10,14-hexadecatetraenyl diphosphate
  • All-trans-geranyl-geranyl-pp
  • Geranylgeranyl-diphosphate
  • Geranylgeranyl-PP
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
FTI 277
1217447-06-7

(2) Tocris Compounds for FNTA Gene

Compound Action Cas Number
FTI 277 Prodrug form of FTI 276 (Cat. No. 2406) 1217447-06-7
LB 42708 Selective farnesyltransferase (FTase) inhibitor 226929-39-1

(4) ApexBio Compounds for FNTA Gene

Compound Action Cas Number
FTI 277 HCl FTase inhibitor 180977-34-8
LB42708 Selective FTase inhibitor 226929-39-1
Lonafarnib Ftase inhibitor,potent and selective 193275-84-2
Tipifarnib (Zarnestra) Farnesyltransferase inhibitor,potent and specific 192185-72-1
genes like me logo Genes that share compounds with FNTA: view

Drug Products

Transcripts for FNTA Gene

Unigene Clusters for FNTA Gene

Farnesyltransferase, CAAX box, alpha:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FNTA
  • Applied Biological Materials Clones for FNTA

Alternative Splicing Database (ASD) splice patterns (SP) for FNTA Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b ^ 11
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: -
SP7: -
SP8:
SP9: - - - -

Relevant External Links for FNTA Gene

GeneLoc Exon Structure for
FNTA
ECgene alternative splicing isoforms for
FNTA

Expression for FNTA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FNTA Gene

Protein differential expression in normal tissues from HIPED for FNTA Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FNTA Gene



Protein tissue co-expression partners for FNTA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FNTA Gene:

FNTA

SOURCE GeneReport for Unigene cluster for FNTA Gene:

Hs.370312

Evidence on tissue expression from TISSUES for FNTA Gene

  • Lung(4.4)
  • Intestine(4.3)
  • Eye(4.2)
  • Nervous system(3.6)
  • Skin(2)
genes like me logo Genes that share expression patterns with FNTA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FNTA Gene

Orthologs for FNTA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FNTA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FNTA 34
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 94 (a)
OneToMany
FNTA 34
  • 92.7 (n)
cow
(Bos Taurus)
Mammalia FNTA 34 35
  • 89.78 (n)
rat
(Rattus norvegicus)
Mammalia Fnta 34
  • 88.42 (n)
mouse
(Mus musculus)
Mammalia Fnta 34 16 35
  • 87.98 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 79 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 82 (a)
OneToMany
FNTA 34
  • 78.72 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 79 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fnta 34
  • 74.06 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12400 34
zebrafish
(Danio rerio)
Actinopterygii fnta 34 35
  • 66.77 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5468 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011767 34
  • 54.9 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2976 36 34 35
  • 54.86 (n)
worm
(Caenorhabditis elegans)
Secernentea fnta-1 34 35
  • 50 (n)
R02D3.5 36
  • 40 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17975g 34
  • 47.45 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAM2 34 35 37
  • 46.64 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR094C 34
  • 46.17 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons FTA 34
  • 50.7 (n)
rice
(Oryza sativa)
Liliopsida Os09g0514400 34
  • 51.85 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2143 35
  • 58 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cwp1 34
  • 50.37 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03632 34
  • 45.29 (n)
Species where no ortholog for FNTA was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FNTA Gene

ENSEMBL:
Gene Tree for FNTA (if available)
TreeFam:
Gene Tree for FNTA (if available)

Paralogs for FNTA Gene

Pseudogenes.org Pseudogenes for FNTA Gene

genes like me logo Genes that share paralogs with FNTA: view

No data available for Paralogs for FNTA Gene

Variants for FNTA Gene

Sequence variations from dbSNP and Humsavar for FNTA Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000012828 -- 43,064,408(+) CCTGG(A/G/T)TTCAA intron-variant
rs1000105422 -- 43,057,729(+) GAGGC(C/G)GGCGG intron-variant
rs1000185007 -- 43,080,929(+) AGAAA(A/C)AGAAA intron-variant
rs1000242759 -- 43,080,878(+) GCAAA(C/T)GTTTA intron-variant
rs1000272992 -- 43,063,245(+) CCGAT(G/T)AATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FNTA Gene

Variant ID Type Subtype PubMed ID
dgv7187n100 CNV gain 25217958
esv2235385 CNV deletion 18987734
esv2547171 CNV deletion 19546169
esv2668009 CNV deletion 23128226
esv3617025 CNV loss 21293372
esv3891387 CNV gain 25118596
nsv1032781 CNV gain 25217958
nsv470208 CNV gain 18288195
nsv831302 CNV loss 17160897
nsv967584 CNV duplication 23825009

Variation tolerance for FNTA Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FNTA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FNTA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNTA Gene

Disorders for FNTA Gene

Relevant External Links for FNTA

Genetic Association Database (GAD)
FNTA
Human Genome Epidemiology (HuGE) Navigator
FNTA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FNTA

No disorders were found for FNTA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FNTA Gene

Publications for FNTA Gene

  1. cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences. (PMID: 8276393) Andres D.A. … Francke U. (Genomics 1993) 2 3 4 64
  2. Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study. (PMID: 19841875) Fontaine-Bisson B. … Morange P.E. (J. Mol. Med. 2010) 3 46 64
  3. Conversion of protein farnesyltransferase to a geranylgeranyltransferase. (PMID: 16893176) Terry K.L. … Beese L.S. (Biochemistry 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity. (PMID: 15170324) Reid T.S. … Beese L.S. (Biochemistry 2004) 3 4 64

Products for FNTA Gene

  • Addgene plasmids for FNTA

Sources for FNTA Gene

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