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Aliases for FNIP2 Gene

Aliases for FNIP2 Gene

  • Folliculin Interacting Protein 2 2 3
  • FNIPL 3 4 6
  • O6-Methylguanine-Induced Apoptosis 1 Protein 3 4
  • FNIP1-Like Protein 3 4
  • KIAA1450 4 6
  • MAPO1 3 4
  • O6-Methylguanine-Induced Apoptosis 1 2
  • Folliculin-Interacting Protein 2 3

External Ids for FNIP2 Gene

Summaries for FNIP2 Gene

GeneCards Summary for FNIP2 Gene

FNIP2 (Folliculin Interacting Protein 2) is a Protein Coding gene. An important paralog of this gene is FNIP1.

UniProtKB/Swiss-Prot for FNIP2 Gene

  • May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNIP2 Gene

Genomics for FNIP2 Gene

Genomic Location for FNIP2 Gene

158,769,030 bp from pter
158,908,050 bp from pter
139,021 bases
Plus strand

Genomic View for FNIP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FNIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNIP2 Gene

Proteins for FNIP2 Gene

  • Protein details for FNIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Folliculin-interacting protein 2
    Protein Accession:
    Secondary Accessions:
    • Q05DC3
    • Q96I31
    • Q9H994

    Protein attributes for FNIP2 Gene

    1114 amino acids
    Molecular mass:
    122115 Da
    Quaternary structure:
    • Forms homomultimers and heteromultimers with FNIP1. Interacts (via C-terminus) with FLCN (via C-terminus). Phosphorylated FLCN is preferentially bound. Interacts with PRKAA1, PRKAB1 and PRKAG1 subunits of 5-AMP-activated protein kinase.
    • Elevated expression levels in histologic variants of renal tumors
    • Sequence=AAH07861.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH16638.1; Type=Miscellaneous discrepancy; Note=Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA95974.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14338.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FNIP2 Gene


neXtProt entry for FNIP2 Gene

Proteomics data for FNIP2 Gene at MOPED

Post-translational modifications for FNIP2 Gene

Other Protein References for FNIP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FNIP2 Gene

Domains for FNIP2 Gene

Protein Domains for FNIP2 Gene


  • Belongs to the FNIP family.:
    • Q9P278
genes like me logo Genes that share domains with FNIP2: view

No data available for Gene Families for FNIP2 Gene

Function for FNIP2 Gene

Molecular function for FNIP2 Gene

UniProtKB/Swiss-Prot Function: May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.

Gene Ontology (GO) - Molecular Function for FNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18403135
genes like me logo Genes that share ontologies with FNIP2: view

miRNA for FNIP2 Gene

miRTarBase miRNAs that target FNIP2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FNIP2 Gene

Localization for FNIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNIP2 Gene

Cytoplasm. Note=Colocalizes with FLCN in the cytoplasm.

Subcellular locations from

Jensen Localization Image for FNIP2 Gene COMPARTMENTS Subcellular localization image for FNIP2 gene
Compartment Confidence
nucleus 4
plasma membrane 4
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with FNIP2: view

Pathways for FNIP2 Gene

SuperPathways for FNIP2 Gene

No Data Available

Interacting Proteins for FNIP2 Gene

Selected Interacting proteins: Q9P278-FNIP2_HUMAN for FNIP2 Gene via MINT I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 21209915
GO:0001932 regulation of protein phosphorylation IDA 18663353
GO:0006468 protein phosphorylation IDA 18663353
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage ISS --
GO:0033138 positive regulation of peptidyl-serine phosphorylation IDA 19914239
genes like me logo Genes that share ontologies with FNIP2: view

No data available for Pathways by source for FNIP2 Gene

Transcripts for FNIP2 Gene

mRNA/cDNA for FNIP2 Gene

(8) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FNIP2 Gene

Folliculin interacting protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FNIP2 Gene

No ASD Table

Relevant External Links for FNIP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FNIP2 Gene

mRNA expression in normal human tissues for FNIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FNIP2 Gene

SOURCE GeneReport for Unigene cluster for FNIP2 Gene Hs.652441

mRNA Expression by UniProt/SwissProt for FNIP2 Gene

Tissue specificity: Widely expressed with highest levels in muscle, nasal mucosa, salivary gland, uvula, fat, liver, heart, placenta and pancreas. Moderately expressed in the lung, small intestine, kidney and brain. Lower levels detected in renal cell carcinoma than in normal kidney tissue. Higher levels detected in oncocytoma than in normal kidney.
genes like me logo Genes that share expressions with FNIP2: view

Orthologs for FNIP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FNIP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FNIP2 36
  • 99.25 (n)
  • 99.01 (a)
FNIP2 37
  • 99 (a)
(Bos Taurus)
Mammalia FNIP2 36
  • 76.51 (n)
  • 78.57 (a)
FNIP2 37
  • 76 (a)
(Canis familiaris)
Mammalia FNIP2 36
  • 85.75 (n)
  • 84.11 (a)
FNIP2 37
  • 81 (a)
(Mus musculus)
Mammalia Fnip2 36
  • 80.65 (n)
  • 79.29 (a)
Fnip2 16
Fnip2 37
  • 77 (a)
(Monodelphis domestica)
Mammalia FNIP2 37
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia FNIP2 37
  • 64 (a)
(Rattus norvegicus)
Mammalia Fnip2 36
  • 81.32 (n)
  • 79.84 (a)
(Gallus gallus)
Aves FNIP2 36
  • 68.22 (n)
  • 69.88 (a)
FNIP2 37
  • 63 (a)
(Anolis carolinensis)
Reptilia FNIP2 37
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fnip2 36
  • 63.95 (n)
  • 63.09 (a)
(Danio rerio)
Actinopterygii FNIP2 37
  • 44 (a)
si:ch211-42i9.8 36
  • 64.15 (n)
  • 66.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3764 37
  • 6 (a)
(Caenorhabditis elegans)
Secernentea T04C4.1 37
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 44 (a)
Species with no ortholog for FNIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FNIP2 Gene

Gene Tree for FNIP2 (if available)
Gene Tree for FNIP2 (if available)

Paralogs for FNIP2 Gene

Paralogs for FNIP2 Gene

Selected SIMAP similar genes for FNIP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FNIP2: view

Variants for FNIP2 Gene

Sequence variations from dbSNP and Humsavar for FNIP2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs2017618 -- 158,889,945(+) GTTGT(C/T)CGTTT intron-variant, utr-variant-3-prime
rs2017619 -- 158,889,946(+) TTGTC(C/T)GTTTT intron-variant, utr-variant-3-prime
rs2017624 -- 158,889,977(+) TGTAA(A/G)AAGCG intron-variant, utr-variant-3-prime
rs2276938 - 158,859,092(+) AGAAA(C/G)CTGTA reference, missense, intron-variant
rs2306205 -- 158,891,830(+) CTTCC(A/G)TGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FNIP2 Gene

Variant ID Type Subtype PubMed ID
nsv830125 CNV Gain 17160897
nsv830127 CNV Loss 17160897
nsv4570 CNV Loss 18451855
esv23058 CNV Loss 19812545
esv2728614 CNV Deletion 23290073
esv2607605 CNV Deletion 19546169
nsv830128 CNV Gain 17160897
esv22076 CNV Loss 19812545
esv2675186 CNV Deletion 23128226
esv2728615 CNV Deletion 23290073

Relevant External Links for FNIP2 Gene

HapMap Linkage Disequilibrium report

Disorders for FNIP2 Gene

(1) University of Copenhagen DISEASES for FNIP2 Gene

Relevant External Links for FNIP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FNIP2: view

No data available for UniProtKB/Swiss-Prot for FNIP2 Gene

Publications for FNIP2 Gene

  1. Identification and characterization of a novel folliculin-interacting protein FNIP2. (PMID: 18403135) Hasumi H. … Schmidt L.S. (Gene 2008) 2 3 4
  2. Interaction of folliculin (Birt-Hogg-Dube gene product) with a novel Fnip1-like (FnipL/Fnip2) protein. (PMID: 18663353) Takagi Y. … Hino O. (Oncogene 2008) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for FNIP2 Gene

Sources for FNIP2 Gene

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