FNIP2 Gene
protein-coding GIFtS: 46
GCID: GC04P159690
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folliculin interacting protein 2
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Aliases
for FNIP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Folliculin Interacting Protein 21 2 | | FNIP1-Like Protein2 3 | | FNIPL1 2 3 5 | | O6-Methylguanine-Induced Apoptosis 1 Protein2 3 | | MAPO11 2 3 | | Folliculin-Interacting Protein 22 | | KIAA14501 3 5 | | |
Export aliases for FNIP2 gene to outside databasesPrevious GC identifers: GC04P159911 GC04P155440 |
Summaries
for FNIP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FNIP2_HUMAN, Q9P278Function: May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions(By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. Mayregulate phosphorylation of RPS6KB1
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Genomic Views
for FNIP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FNIP2 gene promoter:
SREBP-1c NF-E2 p45 HNF-3beta LCR-F1 SREBP-1b PPAR-gamma1 SREBP-1a HFH-1 PPAR-gamma2 NF-E2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FNIP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FNIP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q32.1 Ensembl cytogenetic band: 4q32.1 HGNC cytogenetic band: 4q32.1FNIP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P159690: view genomic region
(about GC identifiers)
Start:
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159,690,182 bp from pter |
End:
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159,829,201 bp from pter |
Size:
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139,020 bases |
Orientation:
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plus strand |
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Proteins
for FNIP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FNIP2_HUMAN, Q9P278 (See
protein sequence)Recommended Name: Folliculin-interacting protein 2 Size: 1114 amino acids; 122115 Da
Subunit: Forms homomultimers and heteromultimers with FNIP1. Interacts (via C-terminus) with FLCN (via C-terminus).Phosphorylated FLCN is preferentially bound. Interacts with PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activatedprotein kinase
Subcellular location: Cytoplasm. Note=Co-localizes with FLCN in the cytoplasm
Miscellaneous: Elevated expression levels in histologic variants of renal tumors
Sequence caution: Sequence=AAH07861.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=AAH16638.1; Type=Miscellaneous discrepancy; Note=Potential poly-A sequence; Sequence=BAA95974.1;Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB14338.1; Type=Erroneous initiation;Note=Translation N-terminally extended;
Secondary accessions: Q05DC3 Q96I31 Q9H994Alternative splicing: 2 isoforms: Q9P278-1 Q9P278-2 Explore the universe of human proteins at neXtProt for FNIP2: NX_Q9P278
Post-translational modifications:
Phosphorylated by AMPK1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P278
FNIP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065891.1
ENSEMBL proteins: ENSP00000264433 ENSP00000421488 ENSP00000420841 ENSP00000368651
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
FNIP2 for ontologies About GeneDecksing
FNIP2 Antibody Products:
Assay Products for FNIP2: |
Protein
Domains /
Families
for FNIP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FNIP2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9P278ProtoNet protein and cluster: Q9P278 UniProtKB/Swiss-Prot: FNIP2_HUMAN, Q9P278Similarity: Belongs to the FNIP family |
Function
for FNIP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FNIP2_HUMAN, Q9P278Function: May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions(By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. Mayregulate phosphorylation of RPS6KB1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNIP2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNIP2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FNIP2 (NM_020840) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FNIP2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNIP2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNIP2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
FNIP2 for ontologies About GeneDecksing
|
Pathways & Interactions
for FNIP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FNIP2
2 Interacting proteins for FNIP2 (Q9P2782, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IDA | -- | | GO:0001932 | regulation of protein phosphorylation |
IDA | 18663353 | | GO:0006468 | protein phosphorylation |
IDA | 18663353 | | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
ISS | -- | | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
IDA | 19914239 |
FNIP2 for ontologies About GeneDecksing
|
Drugs & Compounds
for FNIP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FNIP2
Search CenterWatch for drugs/clinical trials and news about FNIP2
|
Transcripts
for FNIP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FNIP2 gene: NM_020840.1 Unigene Clusters for FNIP2: Folliculin interacting protein 2 Hs.652441 [show with all ESTs], Hs.731810 [show with all ESTs]Unigene Representative Sequences: AK057981, NM_0208407 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000264433(uc003iqe.4) ENST00000504704(uc003iqd.2) ENST00000505445
ENST00000512986 ENST00000504715 ENST00000505130 ENST00000379346
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNIP2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNIP2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FNIP2 (NM_020840) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FNIP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNIP2 |
Additional cDNA sequence: AB040883.1 AK022968.1 BC007861.1 BC016638.1 BC047069.1 7 DOTS entries: DT.214307 DT.91958645 DT.100790618 DT.95089673 DT.95309261 DT.95368336 DT.97791168
GeneLoc Exon Structure
|
Expression
for FNIP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FNIP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATACTTCCA
About this image
See FNIP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FNIP2
SOURCE GeneReport for Unigene clusters: Hs.652441 Hs.731810
UniProtKB/Swiss-Prot: FNIP2_HUMAN, Q9P278Tissue specificity: Widely expressed with highest levels in muscle, nasal mucosa, salivary gland, uvula, fat, liver,heart, placenta and pancreas. Moderately expressed in the lung, small intestine, kidney and brain. Lower levelsdetected in renal cell carcinoma than in normal kidney tissue. Higher levels detected in oncocytoma than in normalkidney
SABiosciences Custom PCR Arrays for FNIP2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FNIP2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FNIP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FNIP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FNIP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNIP2 |
Orthologs
for FNIP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FNIP2 gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for FNIP2 (if available)
TreeFam Gene Tree for FNIP2 (if available) |
Paralogs
for FNIP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FNIP2 gene
- FNIP12
2 SIMAP similar genes for FNIP2 using alignment to 3 protein entries: FNIP2_HUMAN (see all proteins):DKFZp686E18167 FNIP1
FNIP2 for paralogs About GeneDecksing
|
Genomic Variants
for FNIP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for FNIP2
3 CNVs: 98936 4420 80535
8 Indels: 92493 80538 92494 92492 80536 80537 63998 68831 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FNIP2 |
|
Disorders
/ Diseases
for FNIP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FNIP2 for disorders About GeneDecksing
OMIM gene information: 612768
OMIM disorders: --
5  diseases for FNIP2: About MalaCardsoxyphilic adenoma pneumothorax renal cell carcinoma adenoma
carcinoma
1 disease from the University of Copenhagen DISEASES database for FNIP2:Pneumothorax Human Genome Epidemiology (HuGE) Navigator: FNIP2 (1 document)
Export disorders for FNIP2 gene to outside databases
|
Publications
for FNIP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FNIP2 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with FNIP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of a novel folliculin-interacting protein FNIP2. (PubMed id 18403135)1, 2, 3 Hasumi H.... Schmidt L.S. (2008)
- Interaction of folliculin (Birt-Hogg-Dube gene product) with a novel Fnip1-like (FnipL/Fnip2) protein. (PubMed id 18663353)1, 2 Takagi Y....Hino O. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Serine 62 is a phosphorylation site in folliculin, th e Birt-Hogg-DubAc gene product. (PubMed id 19914239)1 Wang L....Hino O. (2010)
- A novel protein, MAPO1, that functions in apoptosis triggered by O6-methylguanine mispair in DNA. (PubMed id 19137017)2 Komori K....Hidaka M. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for FNIP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FNIP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FNIP2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FNIP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FNIP2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for FNIP2 gene:
Search GeneIP for patents involving FNIP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FNIP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for FNIP2 | | Browse OriGene shRNA RFPs | | | Browse OriGene 29mer shRNA kits in GFP-retroviral vector | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FNIP2 | | | OriGene Protein Over-expression Lysate for FNIP2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FNIP2 | | OriGene 3'-UTR Clone for FNIP2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNIP2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNIP2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FNIP2 | | OriGene Custom Protein Services for FNIP2 | | | OriGene Custom Immunoassay Development | | |
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 | | | FNIP2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNIP2 |
|  |  |  | | | | ThermoFisher Antibody for FNIP2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNIP2 |
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