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Aliases for FNIP2 Gene

Aliases for FNIP2 Gene

  • Folliculin Interacting Protein 2 2 3
  • O6-Methylguanine-Induced Apoptosis 1 Protein 3 4
  • FNIP1-Like Protein 3 4
  • FNIPL 3 4
  • MAPO1 3 4
  • O6-Methylguanine-Induced Apoptosis 1 2
  • KIAA1450 4

External Ids for FNIP2 Gene

Previous GeneCards Identifiers for FNIP2 Gene

  • GC04P159911
  • GC04P159690
  • GC04P155440

Summaries for FNIP2 Gene

GeneCards Summary for FNIP2 Gene

FNIP2 (Folliculin Interacting Protein 2) is a Protein Coding gene. Diseases associated with FNIP2 include birt-hogg-dube syndrome. An important paralog of this gene is FNIP1.

UniProtKB/Swiss-Prot for FNIP2 Gene

  • May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNIP2 Gene

Genomics for FNIP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FNIP2 Gene

Chromosome:
4
Start:
158,769,030 bp from pter
End:
158,908,050 bp from pter
Size:
139,021 bases
Orientation:
Plus strand

Genomic View for FNIP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FNIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNIP2 Gene

Proteins for FNIP2 Gene

  • Protein details for FNIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P278-FNIP2_HUMAN
    Recommended name:
    Folliculin-interacting protein 2
    Protein Accession:
    Q9P278
    Secondary Accessions:
    • Q05DC3
    • Q96I31
    • Q9H994

    Protein attributes for FNIP2 Gene

    Size:
    1114 amino acids
    Molecular mass:
    122115 Da
    Quaternary structure:
    • Forms homomultimers and heteromultimers with FNIP1. Interacts (via C-terminus) with FLCN (via C-terminus). Phosphorylated FLCN is preferentially bound. Interacts with PRKAA1, PRKAB1 and PRKAG1 subunits of 5-AMP-activated protein kinase.
    Miscellaneous:
    • Elevated expression levels in histologic variants of renal tumors
    SequenceCaution:
    • Sequence=AAH07861.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH16638.1; Type=Miscellaneous discrepancy; Note=Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA95974.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14338.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FNIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FNIP2 Gene

Proteomics data for FNIP2 Gene at MOPED

Post-translational modifications for FNIP2 Gene

Other Protein References for FNIP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FNIP2 Gene

Domains & Families for FNIP2 Gene

Gene Families for FNIP2 Gene

Protein Domains for FNIP2 Gene

Suggested Antigen Peptide Sequences for FNIP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P278

UniProtKB/Swiss-Prot:

FNIP2_HUMAN :
  • Belongs to the FNIP family.
Family:
  • Belongs to the FNIP family.
genes like me logo Genes that share domains with FNIP2: view

Function for FNIP2 Gene

Molecular function for FNIP2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.

Gene Ontology (GO) - Molecular Function for FNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18403135
genes like me logo Genes that share ontologies with FNIP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FNIP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for FNIP2 Gene

Localization for FNIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNIP2 Gene

Cytoplasm. Note=Colocalizes with FLCN in the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FNIP2 Gene COMPARTMENTS Subcellular localization image for FNIP2 gene
Compartment Confidence
cytoskeleton 4
nucleus 4
plasma membrane 4
cytosol 2

Gene Ontology (GO) - Cellular Components for FNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 18403135
GO:0005815 microtubule organizing center IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with FNIP2: view

Pathways & Interactions for FNIP2 Gene

SuperPathways for FNIP2 Gene

No Data Available

Interacting Proteins for FNIP2 Gene

Selected Interacting proteins: Q9P278-FNIP2_HUMAN for FNIP2 Gene via I2D MINT

Symbol External ID(s) Details
GLI2
--

Gene Ontology (GO) - Biological Process for FNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 21209915
GO:0001932 regulation of protein phosphorylation IDA 18663353
GO:0006468 protein phosphorylation IDA 18663353
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage ISS --
GO:0031334 positive regulation of protein complex assembly IDA 25126726
genes like me logo Genes that share ontologies with FNIP2: view

No data available for Pathways by source and SIGNOR curated interactions for FNIP2 Gene

Drugs & Compounds for FNIP2 Gene

No Compound Related Data Available

Transcripts for FNIP2 Gene

mRNA/cDNA for FNIP2 Gene

(8) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FNIP2 Gene

Folliculin interacting protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FNIP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FNIP2 Gene

No ASD Table

Relevant External Links for FNIP2 Gene

GeneLoc Exon Structure for
FNIP2
ECgene alternative splicing isoforms for
FNIP2

Expression for FNIP2 Gene

mRNA expression in normal human tissues for FNIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FNIP2 Gene

This gene is overexpressed in Oral epithelium (27.6) and Monocytes (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FNIP2 Gene



SOURCE GeneReport for Unigene cluster for FNIP2 Gene Hs.652441

mRNA Expression by UniProt/SwissProt for FNIP2 Gene

Q9P278-FNIP2_HUMAN
Tissue specificity: Widely expressed with highest levels in muscle, nasal mucosa, salivary gland, uvula, fat, liver, heart, placenta and pancreas. Moderately expressed in the lung, small intestine, kidney and brain. Lower levels detected in renal cell carcinoma than in normal kidney tissue. Higher levels detected in oncocytoma than in normal kidney.
genes like me logo Genes that share expression patterns with FNIP2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for FNIP2 Gene

Orthologs for FNIP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FNIP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FNIP2 35
  • 76.51 (n)
  • 78.57 (a)
FNIP2 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FNIP2 35
  • 85.75 (n)
  • 84.11 (a)
FNIP2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fnip2 35
  • 80.65 (n)
  • 79.29 (a)
Fnip2 16
Fnip2 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FNIP2 35
  • 99.25 (n)
  • 99.01 (a)
FNIP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fnip2 35
  • 81.32 (n)
  • 79.84 (a)
oppossum
(Monodelphis domestica)
Mammalia FNIP2 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FNIP2 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves FNIP2 35
  • 68.22 (n)
  • 69.88 (a)
FNIP2 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FNIP2 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fnip2 35
  • 63.95 (n)
  • 63.09 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-42i9.8 35
  • 64.15 (n)
  • 66.35 (a)
FNIP2 36
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3764 36
  • 6 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T04C4.1 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for FNIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FNIP2 Gene

ENSEMBL:
Gene Tree for FNIP2 (if available)
TreeFam:
Gene Tree for FNIP2 (if available)

Paralogs for FNIP2 Gene

Paralogs for FNIP2 Gene

(2) SIMAP similar genes for FNIP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FNIP2: view

Variants for FNIP2 Gene

Sequence variations from dbSNP and Humsavar for FNIP2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_045612 -

Structural Variations from Database of Genomic Variants (DGV) for FNIP2 Gene

Variant ID Type Subtype PubMed ID
nsv830125 CNV Gain 17160897
nsv830127 CNV Loss 17160897
nsv4570 CNV Loss 18451855
esv23058 CNV Loss 19812545
esv2728614 CNV Deletion 23290073
esv2607605 CNV Deletion 19546169
nsv830128 CNV Gain 17160897
esv22076 CNV Loss 19812545
esv2675186 CNV Deletion 23128226
esv2728615 CNV Deletion 23290073

Variation tolerance for FNIP2 Gene

Residual Variation Intolerance Score: 16.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.37; 70.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FNIP2 Gene

HapMap Linkage Disequilibrium report
FNIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNIP2 Gene

Disorders for FNIP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FNIP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
birt-hogg-dube syndrome
  • birt-hogg-dubé syndrome
- elite association
Search FNIP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FNIP2

Genetic Association Database (GAD)
FNIP2
Human Genome Epidemiology (HuGE) Navigator
FNIP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FNIP2
genes like me logo Genes that share disorders with FNIP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FNIP2 Gene

Publications for FNIP2 Gene

  1. Identification and characterization of a novel folliculin-interacting protein FNIP2. (PMID: 18403135) Hasumi H. … Schmidt L.S. (Gene 2008) 2 67
  2. FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation. (PMID: 25126726) Dunlop E.A. … Tee A.R. (Autophagy 2014) 67
  3. Stabilization of MAPO1 by specific binding with folliculin and AMP-activated protein kinase in Oa8P-methylguanine-induced apoptosis. (PMID: 23201403) Sano S. … Hidaka M. (Biochem. Biophys. Res. Commun. 2013) 67
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  5. Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization. (PMID: 21209915) Hong S.B. … Linehan W.M. (PLoS ONE 2010) 67

Products for FNIP2 Gene

Sources for FNIP2 Gene

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