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FNIP2 Gene

protein-coding   GIFtS: 49
GCID: GC04P159690

Folliculin Interacting Protein 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Folliculin Interacting Protein 21 2     O6-Methylguanine-Induced Apoptosis 1 Protein2 3
FNIPL2 3 5     KIAA14503 5
MAPO12 3     O6-Methylguanine-Induced Apoptosis 11
FNIP1-Like Protein2 3     Folliculin-Interacting Protein 22

External Ids:    HGNC: 292801   Entrez Gene: 576002   Ensembl: ENSG000000527957   OMIM: 6127685   UniProtKB: Q9P2783   

Export aliases for FNIP2 gene to outside databases

Previous GC identifers: GC04P159911 GC04P155440


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FNIP2 Gene:
FNIP2 (folliculin interacting protein 2) is a protein-coding gene. An important paralog of this gene is FNIP1.

UniProtKB/Swiss-Prot: FNIP2_HUMAN, Q9P278
Function: May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired
lesions (By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling
pathways. May regulate phosphorylation of RPS6KB1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FNIP2 gene promoter:
         SREBP-1c   NF-E2 p45   HNF-3beta   LCR-F1   SREBP-1b   PPAR-gamma1   SREBP-1a   HFH-1   PPAR-gamma2   NF-E2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FNIP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q32.1   Ensembl cytogenetic band:  4q32.1   HGNC cytogenetic band: 4q32.1

FNIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FNIP2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P159690:  view genomic region     (about GC identifiers)

Start:
159,690,182 bp from pter      End:
159,829,201 bp from pter
Size:
139,020 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FNIP2_HUMAN, Q9P278 (See protein sequence)
Recommended Name: Folliculin-interacting protein 2  
Size: 1114 amino acids; 122115 Da
Subunit: Forms homomultimers and heteromultimers with FNIP1. Interacts (via C-terminus) with FLCN (via
C-terminus). Phosphorylated FLCN is preferentially bound. Interacts with PRKAA1, PRKAB1 and PRKAG1 subunits of
5'-AMP-activated protein kinase
Miscellaneous: Elevated expression levels in histologic variants of renal tumors
Sequence caution: Sequence=AAH07861.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH16638.1; Type=Miscellaneous discrepancy; Note=Potential poly-A sequence; Sequence=BAA95974.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB14338.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Secondary accessions: Q05DC3 Q96I31 Q9H994
Alternative splicing: 2 isoforms:  Q9P278-1   Q9P278-2   

Explore the universe of human proteins at neXtProt for FNIP2: NX_Q9P278

Explore proteomics data for FNIP2 at MOPED

Post-translational modifications: 

  • Phosphorylated by AMPK1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FNIP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065891.1  
    ENSEMBL proteins: 
     ENSP00000264433   ENSP00000421488   ENSP00000420841   ENSP00000368651  

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    antibodies-online antibodies for FNIP2 (41 products) 

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    antibodies-online kits for FNIP2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR028084 FNIP_N_dom
     IPR026156 FNIP_fam
     IPR028086 FNIP_C_dom
     IPR028085 FNIP_mid_dom

    Graphical View of Domain Structure for InterPro Entry Q9P278

    ProtoNet protein and cluster: Q9P278

    UniProtKB/Swiss-Prot: FNIP2_HUMAN, Q9P278
    Similarity: Belongs to the FNIP family


    Find genes that share domains with FNIP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FNIP2_HUMAN, Q9P278
    Function: May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired
    lesions (By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling
    pathways. May regulate phosphorylation of RPS6KB1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18403135
         
    Find genes that share ontologies with FNIP2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FNIP2

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    miRTarBase miRNAs that target FNIP2:
    hsa-mir-186-5p (MIRT045302)

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    hsa-miR-30c hsa-miR-520f hsa-miR-15a hsa-miR-25 hsa-miR-30d hsa-miR-27b* hsa-miR-499-5p hsa-miR-1276
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FNIP2_HUMAN, Q9P278: Cytoplasm. Note=Colocalizes with FLCN in the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    plasma membrane4
    cytosol3
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005815microtubule organizing center IDA--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with FNIP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FNIP2
    Interactions:

        GeneGlobe Interaction Network for FNIP2

    2 Interacting proteins for FNIP2 (Q9P2782, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GLI2P100703I2D: score=2 
    --Q76JQ22MINT-7298229
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA--
    GO:0001932regulation of protein phosphorylation IDA18663353
    GO:0006468protein phosphorylation IDA18663353
    GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage ISS--
    GO:0033138positive regulation of peptidyl-serine phosphorylation IDA19914239

    Find genes that share ontologies with FNIP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for FNIP2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FNIP2 gene: 
    NM_020840.1  

    Unigene Cluster for FNIP2:

    Folliculin interacting protein 2
    Hs.652441  [show with all ESTs]
    Unigene Representative Sequence: AK057981
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264433(uc003iqe.4) ENST00000504704(uc003iqd.2) ENST00000505445
    ENST00000512986 ENST00000504715 ENST00000505130 ENST00000379346
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    hsa-miR-30c hsa-miR-520f hsa-miR-15a hsa-miR-25 hsa-miR-30d hsa-miR-27b* hsa-miR-499-5p hsa-miR-1276
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    Additional mRNA sequence: AK057981.1 

    1 DOTS entry:

    DT.214307 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FNIP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATACTTCCA
    FNIP2 Expression
    About this image


    FNIP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells I Spleen
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
    FNIP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FNIP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.652441

    UniProtKB/Swiss-Prot: FNIP2_HUMAN, Q9P278
    Tissue specificity: Widely expressed with highest levels in muscle, nasal mucosa, salivary gland, uvula, fat,
    liver, heart, placenta and pancreas. Moderately expressed in the lung, small intestine, kidney and brain. Lower
    levels detected in renal cell carcinoma than in normal kidney tissue. Higher levels detected in oncocytoma than
    in normal kidney

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FNIP2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fnip21 , 5 folliculin interacting protein 21, 5 80.65(n)1
    79.29(a)1
      3 (34.91 cM)5
    3296791  NM_001162999.21  NP_001156471.11 
     794559745 
    chicken
    (Gallus gallus)
    Aves FNIP21 folliculin interacting protein 2 68.22(n)
    69.88(a)
      422417  XM_420386.4  XP_420386.3 
    lizard
    (Anolis carolinensis)
    Reptilia FNIP26
    folliculin interacting protein 2
    61(a)
    1 ↔ 1
    5(128288547-128345520)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fnip21 folliculin interacting protein 2 63.95(n)
    63.09(a)
      100493386  XM_002934740.2  XP_002934786.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-42i9.81 si:ch211-42i9.8 64.15(n)
    66.35(a)
      797213  NM_001145618.1  NP_001139090.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG37646
    --
    6(a)
    1 → many
    3L(16987817-17005665)
    worm
    (Caenorhabditis elegans)
    Secernentea T04C4.16
    Protein T04C4.1, isoform a
    12(a)
    1 → many
    IV(2222828-2235711) WBGene00020208


    ENSEMBL Gene Tree for FNIP2 (if available)
    TreeFam Gene Tree for FNIP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FNIP2 gene
    FNIP12  
    2 SIMAP similar genes for FNIP2 using alignment to 3 protein entries:     FNIP2_HUMAN (see all proteins):
    DKFZp686E18167    FNIP1

    Find genes that share paralogs with FNIP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FNIP2 (see all 2014)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs348950701,2
    C--159606111(+) TTTTT-/T/TT  
            
    GACAG
    1 -- int11NA 2
    rs1498613951,2
    --159688239(+) ACCAGA/GATGAG 1 -- us2k10--------
    rs42349231,2
    C,F,A,H--159688477(+) CTGAAC/AGAGTC 1 -- us2k122Minor allele frequency- A:0.43NS EA NA WA CSA 2344
    rs1448294831,2
    --159688592(+) AAAGGA/TCATTT 1 -- us2k10--------
    rs1884293691,2
    --159688677(+) ACAACC/GTATAA 1 -- us2k10--------
    rs1807494241,2
    --159688684(+) ATAAAC/GCCAAT 1 -- us2k10--------
    rs1419565181,2
    C--159688828(+) TAAAC-/ACTT  
            
    AATCC
    1 -- us2k10--------
    rs46915191,2
    C--159688858(+) AAGTCT/CGAAGG 1 -- us2k112Minor allele frequency- C:0.02NA WA CSA EA 374
    rs1401100011,2
    --159689057(+) TGAGTA/CTCCAA 1 -- us2k10--------
    rs1866588301,2
    --159689063(+) TCCAAA/GAGTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FNIP2 (159690182 - 159829201 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for FNIP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2728614CNV Deletion23290073
    esv2607605CNV Deletion19546169
    esv2728615CNV Deletion23290073
    esv2675186CNV Deletion23128226
    nsv4570CNV Loss18451855
    esv23058CNV Loss19812545
    nsv830127CNV Loss17160897
    esv22076CNV Loss19812545
    nsv830128CNV Gain17160897
    nsv830125CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612768    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for FNIP2:
    Pneumothorax

    Find genes that share disorders with FNIP2           About GenesLikeMe

    Genetic Association Database (GAD): FNIP2
    Human Genome Epidemiology (HuGE) Navigator: FNIP2 (1 document)

    Export disorders for FNIP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FNIP2 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with FNIP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel folliculin-interacting protein FNIP2. (PubMed id 18403135)1, 2, 3 Hasumi H.... Schmidt L.S. (Gene 2008)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Interaction of folliculin (Birt-Hogg-Dube gene product) with a novel Fnip1-like (FnipL/Fnip2) protein. (PubMed id 18663353)1, 2 Takagi Y.... Hino O. (Oncogene 2008)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    6. Stabilization of MAPO1 by specific binding with folliculin and AMP-activated protein kinase in Oa8P-methylguanine-induced apoptosis. (PubMed id 23201403)1 Sano S....Hidaka M. (Biochem. Biophys. Res. Commun. 2013)
    7. Serine 62 is a phosphorylation site in folliculin, the Birt-Hogg-DubAc gene product. (PubMed id 19914239)1 Wang L....Hino O. (FEBS Lett. 2010)
    8. A novel protein, MAPO1, that functions in apoptosis triggered by O6- methylguanine mispair in DNA. (PubMed id 19137017)2 Komori K.... Hidaka M. (Oncogene 2009)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57600 HGNC: 29280 Ensembl:ENSG00000052795 euGenes: HUgn57600 ECgene: FNIP2
    H-InvDB: FNIP2

    (According to HUGE)
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    HUGE: KIAA1450

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FNIP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FNIP2 gene:
    Search GeneIP for patents involving FNIP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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