FNIP1 Gene
protein-coding GIFtS: 46
GCID: GC05M130761
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|
folliculin interacting protein 1
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Aliases
for FNIP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Folliculin Interacting Protein 11 2 | | KIAA19611 3 5 | | Folliculin-Interacting Protein 12 |
Export aliases for FNIP1 gene to outside databasesPrevious GC identifers: GC00U921652 GC03M008999 GC05M130792 GC05M131006 GC05M130977 GC05M126169 |
Summaries
for FNIP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FNIP1_HUMAN, Q8TF40Function: May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulatephosphorylation of RPS6KB1
|
Genomic Views
for FNIP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FNIP1 gene promoter:
ISGF-3 Spz1 AML1a HTF Meis-1b RORalpha2 MEF-2A aMEF-2 Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FNIP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FNIP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q23.3 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q23.3FNIP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M130761: view genomic region
(about GC identifiers)
Start:
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130,761,584 bp from pter |
End:
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131,132,756 bp from pter |
Size:
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371,173 bases |
Orientation:
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minus strand |
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Proteins
for FNIP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FNIP1_HUMAN, Q8TF40 (See
protein sequence)Recommended Name: Folliculin-interacting protein 1 Size: 1166 amino acids; 130555 Da
Subunit: Forms homomultimers and heteromultimers with FNIP2. Interacts with FLCN (via C-terminus), with HSPCA and withthe PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase (AMPK). Phosphorylated FLCN and AMPK arepreferentially bound
Subcellular location: Cytoplasm. Note=Co-localizes with FLCN in the cytoplasm
Miscellaneous: Elevated expression levels in histologic variants of renal tumors
Secondary accessions: D6RJH5 Q86T47 Q9BUT0Alternative splicing: 3 isoforms: Q8TF40-1 Q8TF40-2 Q8TF40-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FNIP1: NX_Q8TF40
Post-translational modifications:
Phosphorylated by AMPK1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TF40
FNIP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001008738.2 NP_588613.2
ENSEMBL proteins: ENSP00000426948 ENSP00000309266 ENSP00000310453 ENSP00000421985 ENSP00000425619
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
FNIP1 for ontologies About GeneDecksing
FNIP1 Antibody Products:
Assay Products for FNIP1: |
Protein
Domains /
Families
for FNIP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FNIP1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TF40ProtoNet protein and cluster: Q8TF40 UniProtKB/Swiss-Prot: FNIP1_HUMAN, Q8TF40Similarity: Belongs to the FNIP family |
Function
for FNIP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FNIP1_HUMAN, Q8TF40Function: May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulatephosphorylation of RPS6KB1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNIP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNIP1 (see all 3)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNIP1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005085 | guanyl-nucleotide exchange factor activity |
IDA | -- | | GO:0005515 | protein binding |
IPI | -- |
FNIP1 for ontologies About GeneDecksing
Animal Models:
10 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Fnip1):
FNIP1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for FNIP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FNIP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/14 Interacting proteins for FNIP1 (Q8TF401, 2, 3 ENSP000003104534) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IDA | -- | | GO:0001932 | regulation of protein phosphorylation |
IDA | 18663353 | | GO:0001934 | positive regulation of protein phosphorylation |
IMP | 17028174 | | GO:0002327 | immature B cell differentiation |
ISS | -- | | GO:0002904 | positive regulation of B cell apoptotic process |
ISS | -- |
FNIP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for FNIP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FNIP1
Search CenterWatch for drugs/clinical trials and news about FNIP1
|
Transcripts
for FNIP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FNIP1 gene (2 alternative transcripts): NM_001008738.2 NM_133372.2 Unigene Cluster for FNIP1: Folliculin interacting protein 1 Hs.591273 [show with all ESTs]Unigene Representative Sequence: NM_1333725 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000514667 ENST00000307968(uc003kvs.1 uc003kvt.1) ENST00000307954
ENST00000510461(uc010jdm.1) ENST00000511848(uc003kvu.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNIP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNIP1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FNIP1 (NM_001008738) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FNIP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNIP1 |
Additional cDNA sequence: AB075841.1 AK126675.1 AK292473.1 AL832008.1 AL834127.2 BC001956.1 BC020539.1 CR749426.1 CR936723.1 DQ145719.1 9 DOTS entries: DT.311863 DT.91959863 DT.120807299 DT.120807408 DT.120807392 DT.40198203 DT.40112543 DT.40126084 DT.99944048
GeneLoc Exon Structure
|
Expression
for FNIP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FNIP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FNIP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FNIP1
SOURCE GeneReport for Unigene cluster: Hs.591273
UniProtKB/Swiss-Prot: FNIP1_HUMAN, Q8TF40Tissue specificity: Strong expression is found in the heart, liver placenta, muscle, nasal mucosa, salivary gland anduvula and moderate expression in kidney and lung. Higher levels detected in clear cell renal cell carcinoma (RCC) andchromophobe RCC than in normal kidney tissue
SABiosciences Custom PCR Arrays for FNIP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FNIP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FNIP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FNIP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FNIP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNIP1 |
Orthologs
for FNIP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FNIP1 gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for FNIP1 (if available)
TreeFam Gene Tree for FNIP1 (if available) |
Paralogs
for FNIP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FNIP1 gene
- FNIP22
9 SIMAP similar genes for FNIP1 using alignment to 3 protein entries: FNIP1_HUMAN (see all proteins):KIA001LB RAPGEF6 DKFZp686E18167 DKFZp586O1422 PDZGEF1 RAPGEF2
FNIP2 RAPGEF4 RAPGEF3
FNIP1 for paralogs About GeneDecksing
|
Genomic Variants
for FNIP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FNIP1 (130761584 - 131011584 bp, first 250kb of FNIP1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FNIP1
1 Indel: 40804 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FNIP1 |
|
Disorders
/ Diseases
for FNIP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FNIP1 for disorders About GeneDecksing
OMIM gene information: 610594
OMIM disorders: --
7  diseases for FNIP1: About MalaCardsclear cell renal cell carcinoma oxyphilic adenoma renal cell carcinoma pneumothorax
adenoma carcinoma schizophrenia
1 disease from the University of Copenhagen DISEASES database for FNIP1:Pneumothorax Human Genome Epidemiology (HuGE) Navigator: FNIP1 (1 document)
Export disorders for FNIP1 gene to outside databases
|
Publications
for FNIP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FNIP1 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with FNIP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. (PubMed id 17028174)1, 2, 3 Baba M....Zbar B. (2006)
- Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2, 3 Nagase T.... Ohara O. (2001)
- Interaction of folliculin (Birt-Hogg-Dube gene product) with a novel Fnip1-like (FnipL/Fnip2) protein. (PubMed id 18663353)1, 2 Takagi Y....Hino O. (2008)
- Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
- The folliculin-FNIP1 pathway deleted in human Birt-Hog g-Dube syndrome is required for murine B-cell development. (PubMed id 22709692)1 Baba M....Casellas R. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Serine 62 is a phosphorylation site in folliculin, th e Birt-Hogg-DubAc gene product. (PubMed id 19914239)1 Wang L....Hino O. (2010)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
|
External Searches for FNIP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FNIP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FNIP1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FNIP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for FNIP1 gene:
Search GeneIP for patents involving FNIP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FNIP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FNIP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FNIP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FNIP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FNIP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FNIP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FNIP1 |
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 | | | FNIP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNIP1 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNIP1 |
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