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Aliases for FNIP1 Gene

Aliases for FNIP1 Gene

  • Folliculin Interacting Protein 1 2 3
  • KIAA1961 4 6

External Ids for FNIP1 Gene

Previous GeneCards Identifiers for FNIP1 Gene

  • GC00U921652
  • GC03M008999
  • GC05M130792
  • GC05M131006
  • GC05M130977
  • GC05M126169
  • GC05M130761

Summaries for FNIP1 Gene

GeneCards Summary for FNIP1 Gene

FNIP1 (Folliculin Interacting Protein 1) is a Protein Coding gene. GO annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is FNIP2.

UniProtKB/Swiss-Prot for FNIP1 Gene

  • May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNIP1 Gene

Genomics for FNIP1 Gene

Regulatory Elements for FNIP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FNIP1 Gene

Start:
131,641,714 bp from pter
End:
131,797,063 bp from pter
Size:
155,350 bases
Orientation:
Minus strand

Genomic View for FNIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FNIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNIP1 Gene

Proteins for FNIP1 Gene

  • Protein details for FNIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF40-FNIP1_HUMAN
    Recommended name:
    Folliculin-interacting protein 1
    Protein Accession:
    Q8TF40
    Secondary Accessions:
    • D6RJH5
    • Q86T47
    • Q9BUT0

    Protein attributes for FNIP1 Gene

    Size:
    1166 amino acids
    Molecular mass:
    130555 Da
    Quaternary structure:
    • Forms homomultimers and heteromultimers with FNIP2. Interacts with FLCN (via C-terminus), with HSPCA and with the PRKAA1, PRKAB1 and PRKAG1 subunits of 5-AMP-activated protein kinase (AMPK). Phosphorylated FLCN and AMPK are preferentially bound.
    Miscellaneous:
    • Elevated expression levels in histologic variants of renal tumors

    Alternative splice isoforms for FNIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FNIP1 Gene

Proteomics data for FNIP1 Gene at MOPED

Post-translational modifications for FNIP1 Gene

Other Protein References for FNIP1 Gene

No data available for DME Specific Peptides for FNIP1 Gene

Domains for FNIP1 Gene

Protein Domains for FNIP1 Gene

Suggested Antigen Peptide Sequences for FNIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TF40

UniProtKB/Swiss-Prot:

FNIP1_HUMAN :
  • Q8TF40
Family:
  • Belongs to the FNIP family.
genes like me logo Genes that share domains with FNIP1: view

No data available for Gene Families for FNIP1 Gene

Function for FNIP1 Gene

Molecular function for FNIP1 Gene

UniProtKB/Swiss-Prot Function: May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.

Gene Ontology (GO) - Molecular Function for FNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IDA 22977732
GO:0005515 protein binding IPI 17028174
genes like me logo Genes that share ontologies with FNIP1: view
genes like me logo Genes that share phenotypes with FNIP1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FNIP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FNIP1 Gene

Localization for FNIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNIP1 Gene

Cytoplasm. Note=Colocalizes with FLCN in the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FNIP1 Gene COMPARTMENTS Subcellular localization image for FNIP1 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for FNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17028174
genes like me logo Genes that share ontologies with FNIP1: view

Pathways for FNIP1 Gene

SuperPathways for FNIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 21209915
GO:0001932 regulation of protein phosphorylation IDA 18663353
GO:0001934 positive regulation of protein phosphorylation IMP 17028174
GO:0002327 immature B cell differentiation ISS --
GO:0002904 positive regulation of B cell apoptotic process ISS --
genes like me logo Genes that share ontologies with FNIP1: view

No data available for Pathways by source for FNIP1 Gene

Transcripts for FNIP1 Gene

mRNA/cDNA for FNIP1 Gene

(10) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FNIP1 Gene

Folliculin interacting protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FNIP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FNIP1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FNIP1 Gene

No ASD Table

Relevant External Links for FNIP1 Gene

GeneLoc Exon Structure for
FNIP1
ECgene alternative splicing isoforms for
FNIP1

Expression for FNIP1 Gene

mRNA expression in normal human tissues for FNIP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FNIP1 Gene

SOURCE GeneReport for Unigene cluster for FNIP1 Gene Hs.591273

mRNA Expression by UniProt/SwissProt for FNIP1 Gene

Q8TF40-FNIP1_HUMAN
Tissue specificity: Strong expression is found in the heart, liver placenta, muscle, nasal mucosa, salivary gland and uvula and moderate expression in kidney and lung. Higher levels detected in clear cell renal cell carcinoma (RCC) and chromophobe RCC than in normal kidney tissue.
genes like me logo Genes that share expressions with FNIP1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FNIP1 Gene

Orthologs for FNIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FNIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FNIP1 35
  • 99.77 (n)
  • 99.83 (a)
FNIP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FNIP1 35
  • 93.14 (n)
  • 94.17 (a)
FNIP1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FNIP1 35
  • 93.71 (n)
  • 94.51 (a)
FNIP1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fnip1 35
  • 90.64 (n)
  • 91.5 (a)
Fnip1 16
Fnip1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FNIP1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FNIP1 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fnip1 35
  • 90.64 (n)
  • 91.5 (a)
chicken
(Gallus gallus)
Aves FNIP1 35
  • 75.82 (n)
  • 79.73 (a)
FNIP1 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FNIP1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fnip1 35
  • 72.61 (n)
  • 73.53 (a)
zebrafish
(Danio rerio)
Actinopterygii fnip1 35
  • 63.3 (n)
  • 68.26 (a)
FNIP1 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3764 36
  • 7 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T04C4.1 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for FNIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FNIP1 Gene

ENSEMBL:
Gene Tree for FNIP1 (if available)
TreeFam:
Gene Tree for FNIP1 (if available)

Paralogs for FNIP1 Gene

Paralogs for FNIP1 Gene

Selected SIMAP similar genes for FNIP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FNIP1: view

Variants for FNIP1 Gene

Sequence variations from dbSNP and Humsavar for FNIP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs26003 -- 131,654,691(-) GTCCT(A/G)TGTCC intron-variant
rs26004 -- 131,653,262(+) GCTGG(G/T)CGTGG intron-variant
rs26005 -- 131,652,336(-) CAGGG(C/T)AAAAA intron-variant
rs26006 -- 131,647,075(-) TGGTT(C/T)CTTTT intron-variant
rs26007 -- 131,670,663(+) ATTTA(A/T)TTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FNIP1 Gene

Variant ID Type Subtype PubMed ID
esv2730780 CNV Deletion 23290073
esv2730781 CNV Deletion 23290073
esv1136463 CNV Deletion 17803354
esv990609 CNV Deletion 20482838
esv2730782 CNV Deletion 23290073
esv1591239 CNV Deletion 17803354

Relevant External Links for FNIP1 Gene

HapMap Linkage Disequilibrium report
FNIP1
Human Gene Mutation Database (HGMD)
FNIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNIP1 Gene

Disorders for FNIP1 Gene

(1) University of Copenhagen DISEASES for FNIP1 Gene

Relevant External Links for FNIP1

Genetic Association Database (GAD)
FNIP1
Human Genome Epidemiology (HuGE) Navigator
FNIP1
genes like me logo Genes that share disorders with FNIP1: view

No data available for UniProtKB/Swiss-Prot for FNIP1 Gene

Publications for FNIP1 Gene

  1. Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. (PMID: 17028174) Baba M. … Zbar B. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  3. Interaction of folliculin (Birt-Hogg-Dube gene product) with a novel Fnip1-like (FnipL/Fnip2) protein. (PMID: 18663353) Takagi Y. … Hino O. (Oncogene 2008) 3 4
  4. Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia. (PMID: 18804346) Edwards T.L. … Chen X. (Schizophr. Res. 2008) 3 48
  5. Serine 62 is a phosphorylation site in folliculin, the Birt-Hogg-DubAc gene product. (PMID: 19914239) Wang L. … Hino O. (FEBS Lett. 2010) 3

Products for FNIP1 Gene

Sources for FNIP1 Gene

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