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Aliases for FNDC9 Gene

Aliases for FNDC9 Gene

  • Fibronectin Type III Domain Containing 9 2 3 5
  • C5orf40 3 4
  • Fibronectin Type-III Domain-Containing Protein C5orf40 3
  • Fibronectin Type III Domain-Containing Protein 9 3
  • Chromosome 5 Open Reading Frame 40 2

External Ids for FNDC9 Gene

Previous HGNC Symbols for FNDC9 Gene

  • C5orf40

Previous GeneCards Identifiers for FNDC9 Gene

  • GC05M156768

Summaries for FNDC9 Gene

GeneCards Summary for FNDC9 Gene

FNDC9 (Fibronectin Type III Domain Containing 9) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNDC9 Gene

Genomics for FNDC9 Gene

Regulatory Elements for FNDC9 Gene

Enhancers for FNDC9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F157462 1.6 FANTOM5 Ensembl ENCODE 21.2 -118.6 -118576 2.7 PKNOX1 FOS ZNF263 JUNB TSHZ1 ZNF518A SMARCA4 PBX2 STAT3 NBN NIPAL4 FNDC9 LOC102724404 THG1L ADAM19 HAVCR2 ENSG00000253519
GH05F157538 1.6 FANTOM5 Ensembl ENCODE 14.7 -199.3 -199262 12.8 WRNIP1 YY1 ELK1 GATA2 FOS JUNB NCOA1 TBX21 SMARCA4 PBX2 ADAM19 FNDC9 THG1L NIPAL4 ENSG00000248544 LOC102724404 C5orf52 ITK CYFIP2 ENSG00000253519
GH05F157281 0.9 Ensembl ENCODE 23.3 +62.4 62365 3.1 WRNIP1 ZBTB11 USF2 RAD51 ZFHX2 IKZF1 EGR2 SPI1 FNDC9 ADAM19 ITK NIPAL4 ENSG00000253653 GC05P157304
GH05F157569 1.3 FANTOM5 ENCODE 13.9 -228.2 -228180 8.9 HDGF WRNIP1 SIN3A GLIS2 GATA2 KLF7 ZNF263 SP3 TBX21 MEF2D ADAM19 FNDC9 NIPAL4 LOC102724404 C5orf52 THG1L HAVCR2 ENSG00000253519
GH05F157514 1.2 FANTOM5 Ensembl ENCODE 15 -170.7 -170682 3.7 PKNOX1 BHLHE40 JUNB SIN3A RAD21 NR2F2 JUND PBX2 FOS EGR2 ADAM19 LOC102724404 FNDC9 NIPAL4 ENSG00000248544 CYFIP2 HAVCR2 ENSG00000253519
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FNDC9 on UCSC Golden Path with GeneCards custom track

Genomic Location for FNDC9 Gene

Chromosome:
5
Start:
157,341,599 bp from pter
End:
157,345,721 bp from pter
Size:
4,123 bases
Orientation:
Minus strand

Genomic View for FNDC9 Gene

Genes around FNDC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNDC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNDC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC9 Gene

Proteins for FNDC9 Gene

  • Protein details for FNDC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBE3-FNDC9_HUMAN
    Recommended name:
    Fibronectin type III domain-containing protein 9
    Protein Accession:
    Q8TBE3
    Secondary Accessions:
    • A8K0Y6

    Protein attributes for FNDC9 Gene

    Size:
    224 amino acids
    Molecular mass:
    25275 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FNDC9 Gene

Post-translational modifications for FNDC9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FNDC9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FNDC9 Gene

Domains & Families for FNDC9 Gene

Gene Families for FNDC9 Gene

Protein Domains for FNDC9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FNDC9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TBE3

UniProtKB/Swiss-Prot:

FNDC9_HUMAN :
  • Contains 1 fibronectin type-III domain.
Domain:
  • Contains 1 fibronectin type-III domain.
genes like me logo Genes that share domains with FNDC9: view

Function for FNDC9 Gene

genes like me logo Genes that share phenotypes with FNDC9: view

Animal Model Products

miRNA for FNDC9 Gene

miRTarBase miRNAs that target FNDC9

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FNDC9 Gene

Localization for FNDC9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNDC9 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FNDC9 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FNDC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FNDC9: view

Pathways & Interactions for FNDC9 Gene

SuperPathways for FNDC9 Gene

No Data Available

Interacting Proteins for FNDC9 Gene

Gene Ontology (GO) - Biological Process for FNDC9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FNDC9 Gene

Transcripts for FNDC9 Gene

mRNA/cDNA for FNDC9 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FNDC9 Gene

Fibronectin type III domain containing 9:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC9 Gene

No ASD Table

Relevant External Links for FNDC9 Gene

GeneLoc Exon Structure for
FNDC9
ECgene alternative splicing isoforms for
FNDC9

Expression for FNDC9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FNDC9 Gene

mRNA differential expression in normal tissues according to GTEx for FNDC9 Gene

This gene is overexpressed in Brain - Hypothalamus (x12.4), Brain - Nucleus accumbens (basal ganglia) (x6.4), Pituitary (x5.1), Brain - Frontal Cortex (BA9) (x4.3), and Brain - Cortex (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of FNDC9 Gene:

FNDC9

SOURCE GeneReport for Unigene cluster for FNDC9 Gene:

Hs.437066
genes like me logo Genes that share expression patterns with FNDC9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FNDC9 Gene

Orthologs for FNDC9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FNDC9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FNDC9 34 35
  • 99.26 (n)
dog
(Canis familiaris)
Mammalia FNDC9 34 35
  • 89.58 (n)
cow
(Bos Taurus)
Mammalia FNDC9 34 35
  • 87.54 (n)
rat
(Rattus norvegicus)
Mammalia Fndc9 34
  • 86.46 (n)
mouse
(Mus musculus)
Mammalia Fndc9 34 16 35
  • 84.97 (n)
oppossum
(Monodelphis domestica)
Mammalia FNDC9 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves FNDC9 34 35
  • 56.74 (n)
lizard
(Anolis carolinensis)
Reptilia FNDC9 35
  • 27 (a)
OneToOne
Species where no ortholog for FNDC9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FNDC9 Gene

ENSEMBL:
Gene Tree for FNDC9 (if available)
TreeFam:
Gene Tree for FNDC9 (if available)

Paralogs for FNDC9 Gene

No data available for Paralogs for FNDC9 Gene

Variants for FNDC9 Gene

Sequence variations from dbSNP and Humsavar for FNDC9 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10037386 -- 157,342,641(+) GTGGA(C/T)GCTGC intron-variant, utr-variant-3-prime
rs10037485 -- 157,343,125(+) ACGGA(C/T)ACACC intron-variant, reference, missense
rs10061992 -- 157,343,680(+) AGGCC(A/G)AGAGG intron-variant
rs10062052 -- 157,343,766(+) CCTAA(A/G)AACAG intron-variant
rs10077326 -- 157,343,761(+) TCAGG(C/G)CTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FNDC9 Gene

Variant ID Type Subtype PubMed ID
nsv830526 CNV loss 17160897

Variation tolerance for FNDC9 Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.83; 79.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FNDC9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FNDC9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNDC9 Gene

Disorders for FNDC9 Gene

Relevant External Links for FNDC9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FNDC9

No disorders were found for FNDC9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FNDC9 Gene

Publications for FNDC9 Gene

  1. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J. … Elledge S.J. (Cell 2009) 3 64
  2. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for FNDC9 Gene

Sources for FNDC9 Gene

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