FNDC8 Gene
protein-coding GIFtS: 37
GCID: GC17P033448
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fibronectin type III domain containing 8
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Aliases
for FNDC8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fibronectin Type III Domain Containing 81 2 | | DKFZp434H22151 | | Fibronectin Type III Domain-Containing Protein 82 |
Export aliases for FNDC8 gene to outside databasesPrevious GC identifers: GC17P030473 GC17P029633 |
Summaries
for FNDC8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FNDC8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010799.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FNDC8 gene promoter:
Max1 AML1a NCX/Ncx RREB-1 GATA-1 Max PPAR-gamma1 ZID PPAR-gamma2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for FNDC8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FNDC8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q12FNDC8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P033448: view genomic region
(about GC identifiers)
Start:
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33,448,598 bp from pter |
End:
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33,457,751 bp from pter |
Size:
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9,154 bases |
Orientation:
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plus strand |
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Proteins
for FNDC8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FNDC8_HUMAN, Q8TC99 (See
protein sequence)Recommended Name: Fibronectin type III domain-containing protein 8 Size: 324 amino acids; 35921 Da
Secondary accessions: B2R9G6 Q9UFC2Explore the universe of human proteins at neXtProt for FNDC8: NX_Q8TC99
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TC99
FNDC8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060029.1
ENSEMBL proteins: ENSP00000158009
Human Recombinant Protein Products:
FNDC8 Antibody Products:
Assay Products for FNDC8: |
Protein
Domains /
Families
for FNDC8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FNDC8 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TC99ProtoNet protein and cluster: Q8TC99 UniProtKB/Swiss-Prot: FNDC8_HUMAN, Q8TC99Similarity: Contains 1 fibronectin type-III domain |
Function
for FNDC8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FNDC8 (NM_017559) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FNDC8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNDC8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNDC8 |
|
Pathways & Interactions
for FNDC8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FNDC8
|
Drugs & Compounds
for FNDC8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FNDC8
Search CenterWatch for drugs/clinical trials and news about FNDC8
|
Transcripts
for FNDC8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FNDC8 gene: NM_017559.2 Unigene Cluster for FNDC8: Fibronectin type III domain containing 8 Hs.120369 [show with all ESTs]Unigene Representative Sequence: NM_0175591 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000158009(uc002hix.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FNDC8 (NM_017559) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FNDC8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNDC8 |
Additional cDNA sequence: AK225743.1 AK313775.1 AL133054.1 BC024002.2 1 DOTS entry: DT.442030 22 AceView cDNA sequences: NM_017559 AL133054 BI827781 AI280133 AA932363 BM553227 BG717205 BI828569 BC024002 BX094627 BE465766 BP370899 BI829497 AW665255 AI001168 AI382107 AA442624 AI286158 AA719238 AW339870 BQ292398 AW269016
GeneLoc Exon Structure
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Expression
for FNDC8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FNDC8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAGGCTCAG
About this image
See FNDC8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FNDC8
SOURCE GeneReport for Unigene cluster: Hs.120369
SABiosciences Custom PCR Arrays for FNDC8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FNDC8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FNDC8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FNDC8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FNDC8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNDC8 |
Orthologs
for FNDC8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for FNDC8 gene from 1/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Fndc81 , 5 |
fibronectin type III domain containing 81, 5 |
77.92(n)1
67.83(a)1 |
|
11 (50.30 cM)5
789191 NM_030224.11 NP_084500.11
828921245 |
ENSEMBL Gene Tree for FNDC8 (if available)
TreeFam Gene Tree for FNDC8 (if available) |
Paralogs
for FNDC8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FNDC8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FNDC8 (33448598 - 33457751 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FNDC8: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FNDC8 |
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Disorders
/ Diseases
for FNDC8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 FNDC8 for disorders About MalaCards
FNDC8 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: FNDC8 (1 document)
Export disorders for FNDC8 gene to outside databases
|
Publications
for FNDC8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FNDC8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FNDC8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
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External Searches for FNDC8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FNDC8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FNDC8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FNDC8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FNDC8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FNDC8 gene:
Search GeneIP for patents involving FNDC8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FNDC8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FNDC8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FNDC8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FNDC8 | | | OriGene Protein Over-expression Lysate for FNDC8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FNDC8 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FNDC8 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FNDC8 | | OriGene Custom Protein Services for FNDC8 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FNDC8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FNDC8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FNDC8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FNDC8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FNDC8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FNDC8 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNDC8 |
|  |  |  | | | | Search ThermoFisher Antibodies for FNDC8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNDC8 |
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