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Aliases for FNDC8 Gene

Aliases for FNDC8 Gene

  • Fibronectin Type III Domain Containing 8 2 3 5

External Ids for FNDC8 Gene

Previous GeneCards Identifiers for FNDC8 Gene

  • GC17P030473
  • GC17P033448
  • GC17P029633

Summaries for FNDC8 Gene

GeneCards Summary for FNDC8 Gene

FNDC8 (Fibronectin Type III Domain Containing 8) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNDC8 Gene

Genomics for FNDC8 Gene

Regulatory Elements for FNDC8 Gene

Enhancers for FNDC8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FNDC8 on UCSC Golden Path with GeneCards custom track

Genomic Location for FNDC8 Gene

35,121,579 bp from pter
35,130,732 bp from pter
9,154 bases
Plus strand

Genomic View for FNDC8 Gene

Genes around FNDC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNDC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNDC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC8 Gene

Proteins for FNDC8 Gene

  • Protein details for FNDC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibronectin type III domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • B2R9G6
    • Q9UFC2

    Protein attributes for FNDC8 Gene

    324 amino acids
    Molecular mass:
    35921 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FNDC8 Gene

Proteomics data for FNDC8 Gene at MOPED

Post-translational modifications for FNDC8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FNDC8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FNDC8 Gene

Domains & Families for FNDC8 Gene

Gene Families for FNDC8 Gene

Protein Domains for FNDC8 Gene


Suggested Antigen Peptide Sequences for FNDC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 fibronectin type-III domain.
  • Contains 1 fibronectin type-III domain.
genes like me logo Genes that share domains with FNDC8: view

Function for FNDC8 Gene

Phenotypes for FNDC8 Gene

genes like me logo Genes that share phenotypes with FNDC8: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FNDC8

miRNA for FNDC8 Gene

miRTarBase miRNAs that target FNDC8

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FNDC8 Gene

Localization for FNDC8 Gene

Subcellular locations from

Jensen Localization Image for FNDC8 Gene COMPARTMENTS Subcellular localization image for FNDC8 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FNDC8 Gene

Pathways & Interactions for FNDC8 Gene

SuperPathways for FNDC8 Gene

No Data Available

Interacting Proteins for FNDC8 Gene

Gene Ontology (GO) - Biological Process for FNDC8 Gene


No data available for Pathways by source and SIGNOR curated interactions for FNDC8 Gene

Drugs & Compounds for FNDC8 Gene

No Compound Related Data Available

Transcripts for FNDC8 Gene

mRNA/cDNA for FNDC8 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FNDC8 Gene

Fibronectin type III domain containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC8 Gene

No ASD Table

Relevant External Links for FNDC8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FNDC8 Gene

mRNA expression in normal human tissues for FNDC8 Gene

mRNA differential expression in normal tissues according to GTEx for FNDC8 Gene

This gene is overexpressed in Testis (x49.6).

Protein differential expression in normal tissues from HIPED for FNDC8 Gene

This gene is overexpressed in Testis (37.0) and Ovary (31.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FNDC8 Gene

SOURCE GeneReport for Unigene cluster for FNDC8 Gene Hs.120369

genes like me logo Genes that share expression patterns with FNDC8: view

Protein tissue co-expression partners for FNDC8 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FNDC8 Gene

Orthologs for FNDC8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FNDC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FNDC8 35
  • 83.28 (n)
  • 76.18 (a)
FNDC8 36
  • 76 (a)
(Canis familiaris)
Mammalia FNDC8 35
  • 85.57 (n)
  • 79.75 (a)
FNDC8 36
  • 80 (a)
(Mus musculus)
Mammalia Fndc8 35
  • 77.92 (n)
  • 67.83 (a)
Fndc8 16
Fndc8 36
  • 67 (a)
(Pan troglodytes)
Mammalia FNDC8 35
  • 99.69 (n)
  • 99.69 (a)
FNDC8 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fndc8 35
  • 77.81 (n)
  • 67.83 (a)
(Monodelphis domestica)
Mammalia FNDC8 36
  • 36 (a)
Species with no ortholog for FNDC8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FNDC8 Gene

Gene Tree for FNDC8 (if available)
Gene Tree for FNDC8 (if available)

Paralogs for FNDC8 Gene

No data available for Paralogs for FNDC8 Gene

Variants for FNDC8 Gene

Sequence variations from dbSNP and Humsavar for FNDC8 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_031770 -
rs12952106 - 35,127,211(+) CAATG(A/G)CCAAG reference, missense
rs998286 -- 35,128,001(+) CACCG(C/T)CCTAC intron-variant
rs1138723 -- 35,128,989(-) gattc(C/T)catag intron-variant
rs2128242 -- 35,123,676(+) gaggt(C/T)gcagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FNDC8 Gene

Variant ID Type Subtype PubMed ID
nsv2036 CNV Insertion 18451855

Variation tolerance for FNDC8 Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.67% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FNDC8 Gene

Disorders for FNDC8 Gene

Relevant External Links for FNDC8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FNDC8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FNDC8 Gene

Publications for FNDC8 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  3. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3

Products for FNDC8 Gene

Sources for FNDC8 Gene