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Aliases for FNDC7 Gene

Aliases for FNDC7 Gene

  • Fibronectin Type III Domain Containing 7 2 3 5

External Ids for FNDC7 Gene

Previous GeneCards Identifiers for FNDC7 Gene

  • GC01P108978
  • GC01P109066
  • GC01P109255
  • GC01P107149

Summaries for FNDC7 Gene

GeneCards Summary for FNDC7 Gene

FNDC7 (Fibronectin Type III Domain Containing 7) is a Protein Coding gene.

Additional gene information for FNDC7 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNDC7 Gene

Genomics for FNDC7 Gene

Regulatory Elements for FNDC7 Gene

Enhancers for FNDC7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H108679 0.4 Ensembl 11.8 -32.4 -32416 0 RFX1 ZMYM3 FNDC7 PIR52312 PRPF38B
GH01H108703 1.7 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -8.3 -8260 2 HDAC1 ZBTB40 RUNX3 IKZF2 PAF1 SMARCA5 ZBTB11 CEBPB ELF1 SMARCA4 ENSG00000232971 HENMT1 PRPF38B FAM102B TMEM167B GC01M108671 FNDC7
GH01H108718 1.5 FANTOM5 Ensembl ENCODE 0.4 +8.0 8021 2 HDGF PKNOX1 ZBTB40 EGR1 ZNF366 FOS SMARCC1 CEBPB ZEB2 MAFF PRPF38B STXBP3 FNDC7 ENSG00000232971
GH01H108722 0.4 ENCODE 0.4 +10.0 10002 0 FOXA2 FOXA3 PRPF38B STXBP3 FNDC7 ENSG00000232971
GH01H108725 0.2 ENCODE 0.4 +13.7 13684 0 STXBP3 ENSG00000232971 FNDC7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FNDC7 on UCSC Golden Path with GeneCards custom track

Genomic Location for FNDC7 Gene

Chromosome:
1
Start:
108,712,416 bp from pter
End:
108,743,262 bp from pter
Size:
30,847 bases
Orientation:
Plus strand

Genomic View for FNDC7 Gene

Genes around FNDC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNDC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNDC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC7 Gene

Proteins for FNDC7 Gene

  • Protein details for FNDC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VTL7-FNDC7_HUMAN
    Recommended name:
    Fibronectin type III domain-containing protein 7
    Protein Accession:
    Q5VTL7
    Secondary Accessions:
    • A1L468
    • E9PAZ5
    • Q6PF16
    • Q8NA51

    Protein attributes for FNDC7 Gene

    Size:
    733 amino acids
    Molecular mass:
    78236 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH57762.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI30422.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC04077.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH72065.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for FNDC7 Gene

Post-translational modifications for FNDC7 Gene

  • Glycosylation at posLast=230230 and posLast=433433
  • Modification sites at PhosphoSitePlus

Other Protein References for FNDC7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FNDC7 Gene

Domains & Families for FNDC7 Gene

Gene Families for FNDC7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for FNDC7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FNDC7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FNDC7: view

No data available for UniProtKB/Swiss-Prot for FNDC7 Gene

Function for FNDC7 Gene

genes like me logo Genes that share phenotypes with FNDC7: view

Animal Models for FNDC7 Gene

MGI Knock Outs for FNDC7:

Animal Model Products

CRISPR Products

miRNA for FNDC7 Gene

miRTarBase miRNAs that target FNDC7

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FNDC7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FNDC7 Gene

Localization for FNDC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNDC7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FNDC7 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
nucleus 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FNDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with FNDC7: view

Pathways & Interactions for FNDC7 Gene

SuperPathways for FNDC7 Gene

No Data Available

Interacting Proteins for FNDC7 Gene

Gene Ontology (GO) - Biological Process for FNDC7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FNDC7 Gene

Drugs & Compounds for FNDC7 Gene

No Compound Related Data Available

Transcripts for FNDC7 Gene

mRNA/cDNA for FNDC7 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FNDC7 Gene

Fibronectin type III domain containing 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FNDC7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC7 Gene

No ASD Table

Relevant External Links for FNDC7 Gene

GeneLoc Exon Structure for
FNDC7
ECgene alternative splicing isoforms for
FNDC7

Expression for FNDC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FNDC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FNDC7 Gene

This gene is overexpressed in Testis (x12.7) and Brain - Hippocampus (x4.3).

Protein differential expression in normal tissues from HIPED for FNDC7 Gene

This gene is overexpressed in Esophagus (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FNDC7 Gene



Protein tissue co-expression partners for FNDC7 Gene

NURSA nuclear receptor signaling pathways regulating expression of FNDC7 Gene:

FNDC7

SOURCE GeneReport for Unigene cluster for FNDC7 Gene:

Hs.258253

Evidence on tissue expression from TISSUES for FNDC7 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with FNDC7: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FNDC7 Gene

Orthologs for FNDC7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FNDC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FNDC7 33 34
  • 98.86 (n)
dog
(Canis familiaris)
Mammalia FNDC7 33 34
  • 89.5 (n)
cow
(Bos Taurus)
Mammalia FNDC7 33 34
  • 89.22 (n)
mouse
(Mus musculus)
Mammalia Fndc7 33 16 34
  • 84.7 (n)
rat
(Rattus norvegicus)
Mammalia Fndc7 33
  • 84.47 (n)
oppossum
(Monodelphis domestica)
Mammalia FNDC7 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FNDC7 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves FNDC7 34
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FNDC7 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492589 33
  • 62.23 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100538169 33
  • 55.62 (n)
fndc7 34
  • 47 (a)
OneToMany
FNDC7 (3 of 7) 34
  • 44 (a)
OneToMany
FNDC7 (6 of 7) 34
  • 32 (a)
OneToMany
FNDC7 (5 of 7) 34
  • 27 (a)
OneToMany
FNDC7 (7 of 7) 34
  • 24 (a)
OneToMany
FNDC7 (4 of 7) 34
  • 21 (a)
OneToMany
FNDC7 (1 of 7) 34
  • 5 (a)
OneToMany
Species where no ortholog for FNDC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FNDC7 Gene

ENSEMBL:
Gene Tree for FNDC7 (if available)
TreeFam:
Gene Tree for FNDC7 (if available)

Paralogs for FNDC7 Gene

No data available for Paralogs for FNDC7 Gene

Variants for FNDC7 Gene

Sequence variations from dbSNP and Humsavar for FNDC7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000078062 -- 108,722,043(+) CACCT(A/G)TAGGT intron-variant
rs1000139608 -- 108,732,173(+) GATAA(C/T)ATGGT intron-variant
rs1000256864 -- 108,739,821(+) TTCCC(C/T)TCCTT intron-variant
rs1000284737 -- 108,740,050(+) AAAAA(A/G)TCCCG intron-variant
rs1000439215 -- 108,733,011(+) TTAAG(A/C/T)GATCC intron-variant

Variation tolerance for FNDC7 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.55; 82.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FNDC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FNDC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FNDC7 Gene

Disorders for FNDC7 Gene

Relevant External Links for FNDC7

Genetic Association Database (GAD)
FNDC7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FNDC7

No disorders were found for FNDC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FNDC7 Gene

Publications for FNDC7 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel DP … Karasik D (BMC medical genetics 2007) 45 60
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for FNDC7 Gene

Sources for FNDC7 Gene

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