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FNDC7 Gene

protein-coding   GIFtS: 44
GCID: GC01P109255

Fibronectin Type III Domain Containing 7

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibronectin Type III Domain Containing 71 2
Fibronectin Type III Domain-Containing Protein 72

External Ids:    HGNC: 266681   Entrez Gene: 1634792   Ensembl: ENSG000001431077   UniProtKB: Q5VTL73   

Export aliases for FNDC7 gene to outside databases

Previous GC identifers: GC01P108978 GC01P109066 GC01P107149


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FNDC7 Gene:
FNDC7 (fibronectin type III domain containing 7) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FNDC7 gene promoter:
         Nkx3-1 v4   FOXF2   Bach2   CUTL1   Nkx2-5   LCR-F1   HNF-1A   AREB6   GATA-6   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFNDC7 promoter sequence
   Search Chromatin IP Primers for FNDC7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FNDC7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

FNDC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FNDC7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P109255:  view genomic region     (about GC identifiers)

Start:
109,255,279 bp from pter      End:
109,285,371 bp from pter
Size:
30,093 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FNDC7_HUMAN, Q5VTL7 (See protein sequence)
Recommended Name: Fibronectin type III domain-containing protein 7 precursor  
Size: 733 amino acids; 78236 Da
Sequence caution: Sequence=AAH57762.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI30422.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC04077.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAH72065.1; Type=Erroneous gene model
prediction;
Secondary accessions: A1L468 E9PAZ5 Q6PF16 Q8NA51

Explore the universe of human proteins at neXtProt for FNDC7: NX_Q5VTL7

Explore proteomics data for FNDC7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn230, Asn433
  • Modification sites at PhosphoSitePlus

  • See FNDC7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001138409.1  
    ENSEMBL proteins: 
     ENSP00000359034   ENSP00000405986   ENSP00000271311  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing

    2 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q5VTL7

    ProtoNet protein and cluster: Q5VTL7

    UniProtKB/Swiss-Prot: FNDC7_HUMAN, Q5VTL7
    Similarity: Contains 8 fibronectin type-III domains


    Find genes that share domains with FNDC7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with FNDC7           About GenesLikeMe


    Animal Models:
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    hsa-mir-335-5p (MIRT018351)

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    2 qRT-PCR Assays for microRNAs that regulate FNDC7:
    hsa-miR-34b hsa-miR-874
    SwitchGear 3'UTR luciferase reporter plasmidFNDC7 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FNDC7_HUMAN, Q5VTL7: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane2
    cytoskeleton1
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with FNDC7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FNDC7
    Interactions:

        Search GeneGlobe Interaction Network for FNDC7

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for FNDC7 (ENSP000003590344) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000234370ENSP000004031564STRING: ENSP00000403156
    SIRT2ENSP000002493964STRING: ENSP00000249396
    HDAC6ENSP000003340614STRING: ENSP00000334061
    --ENSP000004021484STRING: ENSP00000402148
    --ENSP000002943904STRING: ENSP00000294390
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FNDC7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FNDC7 gene (2 alternative transcripts): 
    NM_001144937.1  NM_173532.1  

    Unigene Cluster for FNDC7:

    Fibronectin type III domain containing 7
    Hs.258253  [show with all ESTs]
    Unigene Representative Sequence: NM_001144937
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370017(uc001dvx.3) ENST00000445274 ENST00000271311(uc010ova.2)

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate FNDC7:
    hsa-miR-34b hsa-miR-874
    SwitchGear 3'UTR luciferase reporter plasmidFNDC7 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat FNDC7

    Additional mRNA sequence: 

    AK093157.1 BC057762.1 BC130421.1 BC144218.1 

    1 DOTS entry:

    DT.40283888 

    10 AceView cDNA sequences:

    BF059694 NM_173532 AK093157 AW515726 AW590959 AX747961 BC057762 BI462645 
    BI464650 AI908529 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FNDC7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGAAGATG
    FNDC7 Expression
    About this image


    FNDC7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells I Spleen
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
    FNDC7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FNDC7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.258253
        Custom PCR Arrays for FNDC7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNDC7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FNDC7 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fndc71 , 5 fibronectin type III domain containing 71, 5 84.7(n)1
    85.66(a)1
      3 (47.84 cM)5
    3201811  NM_177091.51  NP_796065.21 
     1088553235 
    chicken
    (Gallus gallus)
    Aves FNDC76
    fibronectin type III domain containing 7
    60(a)
    1 ↔ 1
    8(1252809-1263823)
    lizard
    (Anolis carolinensis)
    Reptilia FNDC76
    fibronectin type III domain containing 7
    67(a)
    1 ↔ 1
    GL343211.1(2228509-2242048)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004925891 fibronectin type III domain-containing protein 7-like 62.23(n)
    58.13(a)
      100492589  XM_002932171.2  XP_002932217.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005381691 fibronectin type III domain-containing protein 7-like 55.62(n)
    47.29(a)
      100538169  XM_003197936.2  XP_003197984.1 


    ENSEMBL Gene Tree for FNDC7 (if available)
    TreeFam Gene Tree for FNDC7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FNDC7 (see all 722)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs349882281,2
    C--107152923(+) TTATT-/CTCTCTC 1 -- int10--------
    rs1428966261,2
    --109253611(+) CCCAGC/TGCAAT 1 -- us2k10--------
    rs1474306641,2
    --109253664(+) GCAGAC/TGGCTT 1 -- us2k10--------
    rs729807431,2
    C,F--109253833(+) GTGAGG/CTGTGA 1 -- us2k13Minor allele frequency- C:0.17WA CSA 122
    rs1397074161,2
    --109253878(+) GAGACC/TCCGTC 1 -- us2k10--------
    rs617972721,2
    C,F--109254092(+) ATATAT/CTTTCC 1 -- us2k12Minor allele frequency- C:0.10NA 122
    rs30068621,2
    C,F--109254220(+) tctttT/Gcctaa 1 -- us2k110Minor allele frequency- G:0.18NA WA CSA 254
    rs1433395271,2
    C--109254254(+) TTGTG-/TTTTTT 1 -- us2k10--------
    rs1137748571,2
    C--109254261(+) TTTTTC/TTCTGG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1162105461,2
    C,F--109254293(+) TACATT/ATAGAT 1 -- us2k11Minor allele frequency- A:0.05WA 118

    HapMap Linkage Disequilibrium report for FNDC7 (109255279 - 109285371 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FNDC7: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FNDC7
    DNA2.0 Custom Variant and Variant Library Synthesis for FNDC7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with FNDC7           About GenesLikeMe

    Genetic Association Database (GAD): FNDC7

    Export disorders for FNDC7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FNDC7 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FNDC7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (BMC Med. Genet. 2007)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 163479 HGNC: 26668 AceView: FLJ35838 Ensembl:ENSG00000143107 euGenes: HUgn163479
    ECgene: FNDC7 H-InvDB: FNDC7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FNDC7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FNDC7 gene:
    Search GeneIP for patents involving FNDC7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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