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Aliases for FNDC5 Gene

Aliases for FNDC5 Gene

  • Fibronectin Type III Domain Containing 5 2 3 5
  • Fibronectin Type III Repeat-Containing Protein 2 3 4
  • Irisin 2 3
  • FRCP2 3 4
  • Fibronectin Type III Domain-Containing Protein 5 3

External Ids for FNDC5 Gene

Previous GeneCards Identifiers for FNDC5 Gene

  • GC01M032996
  • GC01M033100
  • GC01M033327
  • GC01M031443

Summaries for FNDC5 Gene

Entrez Gene Summary for FNDC5 Gene

  • This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

GeneCards Summary for FNDC5 Gene

FNDC5 (Fibronectin Type III Domain Containing 5) is a Protein Coding gene. Diseases associated with FNDC5 include Gastric Adenosquamous Carcinoma. GO annotations related to this gene include hormone activity. An important paralog of this gene is FNDC4.

UniProtKB/Swiss-Prot for FNDC5 Gene

  • Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNDC5 Gene

Genomics for FNDC5 Gene

Regulatory Elements for FNDC5 Gene

Enhancers for FNDC5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F032763 1.1 Ensembl ENCODE 27.7 +106.4 106438 4.3 KLF1 KLF17 ZIC2 ZFHX2 POLR2A PATZ1 PRDM10 MAFK MAZ USF2 FNDC5 S100PBP KIAA1522 ENSG00000224066 ENSG00000224409 SYNC YARS IQCC DCDC2B
GH01F032796 0.6 ENCODE 27.5 +73.4 73354 5.5 HDGF PKNOX1 ZMYM3 KLF17 ZNF664 GLIS2 SCRT2 FOS MAFK ZNF652 FNDC5 KIAA1522 SYNC RBBP4 ZBTB8OS S100PBP
GH01F032788 0.7 ENCODE 27.1 +83.1 83071 1.3 TBP PKNOX1 SIN3A ZNF48 YY1 ZNF121 ZNF335 GLIS2 ZNF366 FOS FNDC5 S100PBP YARS SYNC KIAA1522
GH01F032756 1.2 FANTOM5 Ensembl ENCODE 24.4 +112.3 112324 6.8 HDGF PKNOX1 ARNT ARID4B SIN3A YY1 CBX5 FOS SP5 MXD4 FNDC5 S100PBP ENSG00000224409 SYNC KIAA1522 TMEM54
GH01F032876 0.8 Ensembl ENCODE 19.4 -4.0 -4010 1.0 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 FNDC5 KIAA1522 AK2 AZIN2 LOC105378631 HPCA
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FNDC5 on UCSC Golden Path with GeneCards custom track

Promoters for FNDC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000534154 1692 801 UBTF EBF1 THRB ZIC2 HIC1 ZFHX2 POLR2A ZBTB48 ZNF366 EGR1

Genomic Location for FNDC5 Gene

32,862,268 bp from pter
32,872,492 bp from pter
10,225 bases
Minus strand

Genomic View for FNDC5 Gene

Genes around FNDC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNDC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNDC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC5 Gene

Proteins for FNDC5 Gene

  • Protein details for FNDC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibronectin type III domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • A6NMC9
    • D3DPQ6
    • Q6P6D9
    • Q7Z676

    Protein attributes for FNDC5 Gene

    212 amino acids
    Molecular mass:
    23659 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FNDC5 Gene

    Alternative splice isoforms for FNDC5 Gene


neXtProt entry for FNDC5 Gene

Post-translational modifications for FNDC5 Gene

Other Protein References for FNDC5 Gene

No data available for DME Specific Peptides for FNDC5 Gene

Domains & Families for FNDC5 Gene

Gene Families for FNDC5 Gene

Protein Domains for FNDC5 Gene

Suggested Antigen Peptide Sequences for FNDC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 fibronectin type-III domain.
  • Contains 1 fibronectin type-III domain.
genes like me logo Genes that share domains with FNDC5: view

Function for FNDC5 Gene

Molecular function for FNDC5 Gene

UniProtKB/Swiss-Prot Function:
Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.
UniProtKB/Swiss-Prot Induction:
Has been shown to be up-regulated some twofold by muscular exercise at the mRNA and protein level; this effect has been suggested to be mediated by PPARGC1A (PubMed:22237023). However, up-regulation upon exercise could not be reproduced, at least not at the mRNA level (PubMed:24040023).

Gene Ontology (GO) - Molecular Function for FNDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with FNDC5: view
genes like me logo Genes that share phenotypes with FNDC5: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FNDC5 Gene

Localization for FNDC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNDC5 Gene

Cell membrane; Single-pass type I membrane protein. Peroxisome membrane; Single-pass type I membrane protein. Note=Imported in peroxisomes through the PEX5 receptor pathway. {ECO:0000250}.
Irisin: Secreted. Note=Detected in the blood of individuals subjected to endurance exercise. {ECO:0000269 PubMed:22237023}.

Subcellular locations from

Jensen Localization Image for FNDC5 Gene COMPARTMENTS Subcellular localization image for FNDC5 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 4
peroxisome 4
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for FNDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region ISS --
GO:0005777 peroxisome IEA --
GO:0005778 peroxisomal membrane IEA --
GO:0005783 endoplasmic reticulum ISS,IBA --
GO:0005886 plasma membrane ISS,IBA --
genes like me logo Genes that share ontologies with FNDC5: view

Pathways & Interactions for FNDC5 Gene

SuperPathways for FNDC5 Gene

No Data Available

Interacting Proteins for FNDC5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000362570 Q8NAU1-FNDC5_HUMAN for FNDC5 Gene via STRING IID

Gene Ontology (GO) - Biological Process for FNDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0014850 response to muscle activity ISS --
GO:0090336 positive regulation of brown fat cell differentiation ISS,IBA --
genes like me logo Genes that share ontologies with FNDC5: view

No data available for Pathways by source and SIGNOR curated interactions for FNDC5 Gene

Transcripts for FNDC5 Gene

Unigene Clusters for FNDC5 Gene

Fibronectin type III domain containing 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: -
SP2: - - - -
SP3: - -
SP4: - -

Relevant External Links for FNDC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FNDC5 Gene

mRNA expression in normal human tissues for FNDC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FNDC5 Gene

This gene is overexpressed in Muscle - Skeletal (x10.3), Brain - Cerebellum (x5.3), Heart - Left Ventricle (x4.3), and Brain - Cerebellar Hemisphere (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of FNDC5 Gene:


SOURCE GeneReport for Unigene cluster for FNDC5 Gene:


mRNA Expression by UniProt/SwissProt for FNDC5 Gene:

Tissue specificity: Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen.
genes like me logo Genes that share expression patterns with FNDC5: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for FNDC5 Gene

Orthologs for FNDC5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FNDC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FNDC5 35
  • 100 (a)
(Canis familiaris)
Mammalia FNDC5 34 35
  • 92.52 (n)
(Rattus norvegicus)
Mammalia Fndc5 34
  • 92.19 (n)
(Mus musculus)
Mammalia Fndc5 34 16 35
  • 90.59 (n)
(Monodelphis domestica)
Mammalia FNDC5 35
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia FNDC5 35
  • 57 (a)
(Bos Taurus)
Mammalia FNDC5 35
  • 45 (a)
(Gallus gallus)
Aves FNDC5 34 35
  • 82.17 (n)
(Anolis carolinensis)
Reptilia FNDC5 35
  • 30 (a)
(Danio rerio)
Actinopterygii fndc5a 34 35
  • 71.82 (n)
fndc5b 35
  • 52 (a)
Species where no ortholog for FNDC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FNDC5 Gene

Gene Tree for FNDC5 (if available)
Gene Tree for FNDC5 (if available)

Paralogs for FNDC5 Gene

Paralogs for FNDC5 Gene

(1) SIMAP similar genes for FNDC5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FNDC5: view

Variants for FNDC5 Gene

Sequence variations from dbSNP and Humsavar for FNDC5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10753268 -- 32,873,002(+) TCTGG(G/T)GAAAG upstream-variant-2KB
rs10753269 -- 32,873,090(+) AGCTG(A/T)CAGAA upstream-variant-2KB
rs10798919 -- 32,871,796(+) CCCCA(A/G)CCAGA intron-variant, upstream-variant-2KB
rs10914628 -- 32,865,161(+) ATGGC(A/G)CGATC intron-variant
rs10914629 -- 32,866,989(+) GGAGG(A/C)TAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FNDC5 Gene

Variant ID Type Subtype PubMed ID
nsv516302 CNV loss 19592680
nsv950584 CNV deletion 24416366

Variation tolerance for FNDC5 Gene

Gene Damage Index Score: 1.11; 22.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FNDC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNDC5 Gene

Disorders for FNDC5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FNDC5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
gastric adenosquamous carcinoma
  • adenosquamous carcinoma of stomach
- elite association - COSMIC cancer census association via MalaCards
Search FNDC5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FNDC5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FNDC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FNDC5 Gene

Publications for FNDC5 Gene

  1. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. (PMID: 22237023) Bostrom P. … Spiegelman B.M. (Nature 2012) 2 3 4 64
  2. Exercise induces hippocampal BDNF through a PGC-1I+/FNDC5 pathway. (PMID: 24120943) Wrann C.D. … Spiegelman B.M. (Cell Metab. 2013) 2 3 64
  3. Evidence against a Beneficial Effect of Irisin in Humans. (PMID: 24040023) Raschke S. … Eckel J. (PLoS ONE 2013) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Frcp1 and Frcp2, two novel fibronectin type III repeat containing genes. (PMID: 12384288) Teufel A. … Westphal H. (Gene 2002) 2 3 64

Products for FNDC5 Gene

Sources for FNDC5 Gene

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