Aliases for FNDC5 Gene
External Ids for FNDC5 Gene
Previous GeneCards Identifiers for FNDC5 Gene
This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
GeneCards Summary for FNDC5 Gene
FNDC5 (Fibronectin Type III Domain Containing 5) is a Protein Coding gene. Diseases associated with FNDC5 include gastric adenosquamous carcinoma. GO annotations related to this gene include hormone activity. An important paralog of this gene is FNDC4.
UniProtKB/Swiss-Prot for FNDC5 Gene
Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.