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Aliases for FNDC4 Gene

Aliases for FNDC4 Gene

  • Fibronectin Type III Domain Containing 4 2 3 5
  • Fibronectin Type III Repeat-Containing Protein 1 3 4
  • FRCP1 3 4
  • Fibronectin Type III Domain-Containing Protein 4 3

External Ids for FNDC4 Gene

Previous GeneCards Identifiers for FNDC4 Gene

  • GC02M027689
  • GC02M027626
  • GC02M027568
  • GC02M027714
  • GC02M027456

Summaries for FNDC4 Gene

GeneCards Summary for FNDC4 Gene

FNDC4 (Fibronectin Type III Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is FNDC5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNDC4 Gene

Genomics for FNDC4 Gene

Regulatory Elements for FNDC4 Gene

Enhancers for FNDC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F027794 1.6 FANTOM5 Ensembl ENCODE 11.1 -303.0 -302958 6.6 ATF1 SIN3A DMAP1 BRCA1 ZNF2 FOS SP3 SP5 MXD4 MIER2 MRPL33 FNDC4 PLB1 LOC102723530 SNRPGP7 SNX17 RBKS ATRAID GC02P027841
GH02F027953 1.6 FANTOM5 Ensembl ENCODE 9.1 -462.4 -462405 9.4 PKNOX1 MLX SIN3A YY1 FOS REST PPARG SSRP1 PBX2 STAT3 FOSL2 RBKS FLJ31356 FNDC4 C2orf16 CGREF1 LINC01460 BRE GCKR LOC100422227
GH02F027734 1.6 FANTOM5 Ensembl ENCODE 7.7 -241.7 -241721 4.4 ATF1 MLX ARID4B SIN3A ZNF48 YY1 ELK1 ZHX2 REST PPARG MRPL33 LINC01460 PLB1 SNRPGP7 LOC102723530 FLJ31356 FOSL2 FNDC4 RBKS
GH02F027427 1.1 ENCODE 10.6 +65.5 65488 4.8 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 SNX17 GPN1 CAD LOC105374363 NRBP1 GTF3C2-AS1 ZNF513 FNDC4 GCKR IFT172
GH02F027765 1.1 Ensembl ENCODE 9.7 -270.7 -270745 1.7 KLF1 CEBPG TEAD3 ZNF316 ZFHX2 PATZ1 NFE2 E2F6 EGR2 SP3 FNDC4 LOC105374363 MRPL33 LINC01460
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FNDC4 on UCSC Golden Path with GeneCards custom track

Promoters for FNDC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001540588 296 1601 ARID4B SIN3A ZNF48 ZBTB40 DNMT3B RAD21 YY1 GLIS2 GATA4 EGR1

Genomic Location for FNDC4 Gene

Chromosome:
2
Start:
27,491,883 bp from pter
End:
27,495,296 bp from pter
Size:
3,414 bases
Orientation:
Minus strand

Genomic View for FNDC4 Gene

Genes around FNDC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNDC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNDC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC4 Gene

Proteins for FNDC4 Gene

  • Protein details for FNDC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6D8-FNDC4_HUMAN
    Recommended name:
    Fibronectin type III domain-containing protein 4
    Protein Accession:
    Q9H6D8
    Secondary Accessions:
    • D6W560

    Protein attributes for FNDC4 Gene

    Size:
    234 amino acids
    Molecular mass:
    25159 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FNDC4 Gene

Post-translational modifications for FNDC4 Gene

  • Glycosylation at Asn 52, Asn 97, and Asn 147
  • Modification sites at PhosphoSitePlus

Other Protein References for FNDC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FNDC4 Gene

Domains & Families for FNDC4 Gene

Gene Families for FNDC4 Gene

Protein Domains for FNDC4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FNDC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6D8

UniProtKB/Swiss-Prot:

FNDC4_HUMAN :
  • Contains 1 fibronectin type-III domain.
Domain:
  • Contains 1 fibronectin type-III domain.
genes like me logo Genes that share domains with FNDC4: view

Function for FNDC4 Gene

genes like me logo Genes that share phenotypes with FNDC4: view

Animal Model Products

miRNA for FNDC4 Gene

miRTarBase miRNAs that target FNDC4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FNDC4 Gene

Localization for FNDC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNDC4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FNDC4 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
extracellular 1
mitochondrion 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FNDC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0005886 plasma membrane IEA,ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FNDC4: view

Pathways & Interactions for FNDC4 Gene

SuperPathways for FNDC4 Gene

No Data Available

Interacting Proteins for FNDC4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000264703%0d%0a9606.ENSP00000301788%0d%0a
Selected Interacting proteins: ENSP00000264703 Q9H6D8-FNDC4_HUMAN for FNDC4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for FNDC4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FNDC4 Gene

Transcripts for FNDC4 Gene

mRNA/cDNA for FNDC4 Gene

Unigene Clusters for FNDC4 Gene

Fibronectin type III domain containing 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2: -
SP3:
SP4: - -

Relevant External Links for FNDC4 Gene

GeneLoc Exon Structure for
FNDC4
ECgene alternative splicing isoforms for
FNDC4

Expression for FNDC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FNDC4 Gene

mRNA differential expression in normal tissues according to GTEx for FNDC4 Gene

This gene is overexpressed in Liver (x6.9) and Adrenal Gland (x5.7).

NURSA nuclear receptor signaling pathways regulating expression of FNDC4 Gene:

FNDC4

SOURCE GeneReport for Unigene cluster for FNDC4 Gene:

Hs.732184
genes like me logo Genes that share expression patterns with FNDC4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FNDC4 Gene

Orthologs for FNDC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FNDC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FNDC4 34 35
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia FNDC4 34 35
  • 92.44 (n)
cow
(Bos Taurus)
Mammalia FNDC4 34 35
  • 92 (n)
mouse
(Mus musculus)
Mammalia Fndc4 34 16 35
  • 89.28 (n)
oppossum
(Monodelphis domestica)
Mammalia FNDC4 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FNDC4 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves FNDC4 34 35
  • 69.77 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia fndc4 34
  • 67.49 (n)
zebrafish
(Danio rerio)
Actinopterygii fndc4a 34 35
  • 66.67 (n)
FNDC4 (1 of 2) 35
  • 54 (a)
OneToMany
Species where no ortholog for FNDC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FNDC4 Gene

ENSEMBL:
Gene Tree for FNDC4 (if available)
TreeFam:
Gene Tree for FNDC4 (if available)

Paralogs for FNDC4 Gene

Paralogs for FNDC4 Gene

(1) SIMAP similar genes for FNDC4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FNDC4: view

Variants for FNDC4 Gene

Sequence variations from dbSNP and Humsavar for FNDC4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10206760 -- 27,492,985(+) TCCCC(A/G)CTCCA intron-variant
rs1046558 -- 27,494,020(-) GCATC(A/G)GCCTT reference, missense
rs111256587 -- 27,496,398(+) CTTCT(A/T)CTGCC upstream-variant-2KB
rs111461122 -- 27,495,945(+) GAGAC(-/AATGTTG)GGGAA upstream-variant-2KB
rs111646981 -- 27,495,656(+) CTTTC(A/T)TTTAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FNDC4 Gene

Variant ID Type Subtype PubMed ID
nsv817684 CNV gain 17921354

Variation tolerance for FNDC4 Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FNDC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FNDC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNDC4 Gene

Disorders for FNDC4 Gene

Relevant External Links for FNDC4

Genetic Association Database (GAD)
FNDC4
Human Genome Epidemiology (HuGE) Navigator
FNDC4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FNDC4

No disorders were found for FNDC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FNDC4 Gene

Publications for FNDC4 Gene

  1. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PMID: 22267201) Stolk L. … Lunetta K.L. (Nat. Genet. 2012) 3 46 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for FNDC4 Gene

Sources for FNDC4 Gene

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