Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FNDC4 Gene

Aliases for FNDC4 Gene

  • Fibronectin Type III Domain Containing 4 2 3
  • FRCP1 3 4 6
  • Fibronectin Type III Repeat-Containing Protein 1 3 4
  • Fibronectin Type III Domain-Containing Protein 4 3

External Ids for FNDC4 Gene

Previous GeneCards Identifiers for FNDC4 Gene

  • GC02M027689
  • GC02M027626
  • GC02M027568
  • GC02M027714
  • GC02M027456

Summaries for FNDC4 Gene

GeneCards Summary for FNDC4 Gene

FNDC4 (Fibronectin Type III Domain Containing 4) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNDC4 Gene

Genomics for FNDC4 Gene

Regulatory Elements for FNDC4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FNDC4 Gene

27,491,883 bp from pter
27,495,259 bp from pter
3,377 bases
Minus strand

Genomic View for FNDC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FNDC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC4 Gene

Proteins for FNDC4 Gene

  • Protein details for FNDC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibronectin type III domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • D6W560

    Protein attributes for FNDC4 Gene

    234 amino acids
    Molecular mass:
    25159 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FNDC4 Gene

Proteomics data for FNDC4 Gene at MOPED

Post-translational modifications for FNDC4 Gene

  • Glycosylation at Asn52, Asn97, and Asn147
  • Modification sites at PhosphoSitePlus

Other Protein References for FNDC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FNDC4 Gene

Domains for FNDC4 Gene

Gene Families for FNDC4 Gene

Protein Domains for FNDC4 Gene


Suggested Antigen Peptide Sequences for FNDC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 fibronectin type-III domain.
  • Contains 1 fibronectin type-III domain.
genes like me logo Genes that share domains with FNDC4: view

Function for FNDC4 Gene

Gene Ontology (GO) - Molecular Function for FNDC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FNDC4: view

Animal Model Products

miRNA for FNDC4 Gene

miRTarBase miRNAs that target FNDC4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FNDC4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for FNDC4 Gene

Localization for FNDC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNDC4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for FNDC4 Gene COMPARTMENTS Subcellular localization image for FNDC4 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 4
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FNDC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0005886 plasma membrane ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FNDC4: view

Pathways for FNDC4 Gene

SuperPathways for FNDC4 Gene

No Data Available

Interacting Proteins for FNDC4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000264703 for FNDC4 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FNDC4 Gene


No data available for Pathways by source for FNDC4 Gene

Transcripts for FNDC4 Gene

mRNA/cDNA for FNDC4 Gene

Unigene Clusters for FNDC4 Gene

Fibronectin type III domain containing 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FNDC4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2: -
SP4: - -

Relevant External Links for FNDC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FNDC4 Gene

mRNA expression in normal human tissues for FNDC4 Gene

mRNA differential expression in normal tissues according to GTEx for FNDC4 Gene

This gene is overexpressed in Liver (6.9) and Adrenal Gland (5.7).

SOURCE GeneReport for Unigene cluster for FNDC4 Gene Hs.732184

genes like me logo Genes that share expressions with FNDC4: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for FNDC4 Gene

Orthologs for FNDC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FNDC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FNDC4 35
  • 92 (n)
  • 97.33 (a)
FNDC4 36
  • 95 (a)
(Canis familiaris)
Mammalia FNDC4 35
  • 92.44 (n)
  • 97.33 (a)
FNDC4 36
  • 96 (a)
(Mus musculus)
Mammalia Fndc4 35
  • 89.28 (n)
  • 96.48 (a)
Fndc4 16
Fndc4 36
  • 96 (a)
(Pan troglodytes)
Mammalia FNDC4 35
  • 99.72 (n)
  • 99.57 (a)
FNDC4 36
  • 100 (a)
(Monodelphis domestica)
Mammalia FNDC4 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia FNDC4 36
  • 51 (a)
(Gallus gallus)
Aves FNDC4 35
  • 69.77 (n)
  • 70.7 (a)
FNDC4 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fndc4 35
  • 67.49 (n)
  • 67.98 (a)
(Danio rerio)
Actinopterygii fndc4a 35
  • 66.67 (n)
  • 66.15 (a)
FNDC4 (1 of 2) 36
  • 54 (a)
fndc4a 36
  • 60 (a)
Species with no ortholog for FNDC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FNDC4 Gene

Gene Tree for FNDC4 (if available)
Gene Tree for FNDC4 (if available)

Paralogs for FNDC4 Gene

(1) SIMAP similar genes for FNDC4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FNDC4: view

No data available for Paralogs for FNDC4 Gene

Variants for FNDC4 Gene

Sequence variations from dbSNP and Humsavar for FNDC4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs575457117 -- 27,492,973(+) GAACT(A/G)AGTAT intron-variant
rs574270733 -- 27,493,340(+) TGCCA(C/G)CTCAC intron-variant
rs573383530 -- 27,493,049(+) TGTTG(C/T)CCAGG intron-variant
rs572820206 -- 27,493,875(+) GTAAG(A/T)AAGAG intron-variant
rs571783221 -- 27,491,901(+) AGAAC(C/T)TTTAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FNDC4 Gene

Variant ID Type Subtype PubMed ID
nsv817684 CNV Gain 17921354

Relevant External Links for FNDC4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNDC4 Gene

Disorders for FNDC4 Gene

Relevant External Links for FNDC4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for FNDC4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FNDC4 Gene

Publications for FNDC4 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for FNDC4 Gene

Sources for FNDC4 Gene

Back to Top