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Aliases for FNDC4 Gene

Aliases for FNDC4 Gene

  • Fibronectin Type III Domain Containing 4 2 3 5
  • Fibronectin Type III Repeat-Containing Protein 1 3 4
  • FRCP1 3 4
  • Fibronectin Type III Domain-Containing Protein 4 3

External Ids for FNDC4 Gene

Previous GeneCards Identifiers for FNDC4 Gene

  • GC02M027689
  • GC02M027626
  • GC02M027568
  • GC02M027714
  • GC02M027456

Summaries for FNDC4 Gene

GeneCards Summary for FNDC4 Gene

FNDC4 (Fibronectin Type III Domain Containing 4) is a Protein Coding gene. Diseases associated with FNDC4 include Fuchs' Endothelial Dystrophy. An important paralog of this gene is FNDC5.

Additional gene information for FNDC4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNDC4 Gene

Genomics for FNDC4 Gene

Regulatory Elements for FNDC4 Gene

Enhancers for FNDC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H027794 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -303.0 -302958 6 ATF1 SIN3A DMAP1 BRCA1 ZNF2 ATF7 FOS SP3 SP5 MXD4 MRPL33 FNDC4 LOC102723530 PLB1 SNRPGP7 SNX17 RBKS ATRAID GC02P027841
GH02H027953 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.1 -461.9 -461937 8 PKNOX1 MLX SIN3A YY1 FOS RUNX3 REST PPARG NFIL3 SSRP1 FOSL2 RBKS FLJ31356 FNDC4 C2orf16 CGREF1 LINC01460 BABAM2 GCKR LOC100422227
GH02H027734 1.8 FANTOM5 Ensembl ENCODE dbSUPER 7.7 -241.8 -241808 4 FOXA2 ATF1 MLX ARID4B SIN3A YY1 ZNF766 ELK1 ZNF143 ATF7 MRPL33 LINC01460 LOC102723530 SNRPGP7 PLB1 FLJ31356 FOSL2 FNDC4 RBKS
GH02H027770 1.4 ENCODE dbSUPER 9.3 -277.3 -277265 3 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B FNDC4 MRPL33 GC02P027841
GH02H027714 1.5 FANTOM5 ENCODE dbSUPER 8.5 -220.9 -220878 3 KLF17 SIN3A RARA ZNF121 GLIS2 EGR1 SCRT2 SMARCC1 ZNF398 ZFP69B SNX17 FNDC4 KRTCAP3 OST4 TRIM54 LINC01460 LOC105374378
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FNDC4 on UCSC Golden Path with GeneCards custom track

Promoters for FNDC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000114428 96 801 CTCF MXI1 SAP130 ARID4B SIN3A ZBTB40 ZNF664 ZFHX2 GLIS2 EGR1

Genomic Location for FNDC4 Gene

27,491,883 bp from pter
27,495,296 bp from pter
3,414 bases
Minus strand

Genomic View for FNDC4 Gene

Genes around FNDC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNDC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNDC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC4 Gene

Proteins for FNDC4 Gene

  • Protein details for FNDC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibronectin type III domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • D6W560

    Protein attributes for FNDC4 Gene

    234 amino acids
    Molecular mass:
    25159 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FNDC4 Gene

Post-translational modifications for FNDC4 Gene

  • Glycosylation at isoforms=52, posLast=9797, and posLast=147147
  • Modification sites at PhosphoSitePlus

Other Protein References for FNDC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FNDC4 Gene

Domains & Families for FNDC4 Gene

Gene Families for FNDC4 Gene

Protein Domains for FNDC4 Gene


Suggested Antigen Peptide Sequences for FNDC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FNDC4: view

No data available for UniProtKB/Swiss-Prot for FNDC4 Gene

Function for FNDC4 Gene

Phenotypes From GWAS Catalog for FNDC4 Gene

genes like me logo Genes that share phenotypes with FNDC4: view

Animal Model Products

CRISPR Products

miRNA for FNDC4 Gene

miRTarBase miRNAs that target FNDC4

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FNDC4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FNDC4 Gene

Localization for FNDC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNDC4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FNDC4 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
extracellular 1
mitochondrion 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Aggresome (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FNDC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space ISS --
GO:0005783 endoplasmic reticulum ISS --
GO:0005886 plasma membrane IEA,ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FNDC4: view

Pathways & Interactions for FNDC4 Gene

SuperPathways for FNDC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FNDC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050728 negative regulation of inflammatory response ISS --
GO:0071559 response to transforming growth factor beta IEP 27066907
genes like me logo Genes that share ontologies with FNDC4: view

No data available for Pathways by source and SIGNOR curated interactions for FNDC4 Gene

Drugs & Compounds for FNDC4 Gene

No Compound Related Data Available

Transcripts for FNDC4 Gene

mRNA/cDNA for FNDC4 Gene

Unigene Clusters for FNDC4 Gene

Fibronectin type III domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FNDC4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2: -
SP4: - -

Relevant External Links for FNDC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FNDC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FNDC4 Gene

mRNA differential expression in normal tissues according to GTEx for FNDC4 Gene

This gene is overexpressed in Liver (x6.9) and Adrenal Gland (x5.7).

NURSA nuclear receptor signaling pathways regulating expression of FNDC4 Gene:


SOURCE GeneReport for Unigene cluster for FNDC4 Gene:


Evidence on tissue expression from TISSUES for FNDC4 Gene

  • Nervous system(4.6)
  • Liver(3.5)
  • Lung(2.7)
genes like me logo Genes that share expression patterns with FNDC4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FNDC4 Gene

Orthologs for FNDC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FNDC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FNDC4 33 34
  • 99.72 (n)
(Canis familiaris)
Mammalia FNDC4 33 34
  • 92.44 (n)
(Bos Taurus)
Mammalia FNDC4 33 34
  • 92 (n)
(Mus musculus)
Mammalia Fndc4 33 16 34
  • 89.28 (n)
(Monodelphis domestica)
Mammalia FNDC4 34
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia FNDC4 34
  • 51 (a)
(Gallus gallus)
Aves FNDC4 33 34
  • 69.77 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia fndc4 33
  • 67.49 (n)
(Danio rerio)
Actinopterygii fndc4a 33 34
  • 66.67 (n)
FNDC4 (1 of 2) 34
  • 54 (a)
Species where no ortholog for FNDC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FNDC4 Gene

Gene Tree for FNDC4 (if available)
Gene Tree for FNDC4 (if available)

Paralogs for FNDC4 Gene

Paralogs for FNDC4 Gene

(1) SIMAP similar genes for FNDC4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FNDC4: view

Variants for FNDC4 Gene

Sequence variations from dbSNP and Humsavar for FNDC4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000571428 -- 27,492,517(+) GGAAG(C/G)TAATA intron-variant
rs1001692053 -- 27,495,844(+) CTTAC(G/T)GTGTG upstream-variant-2KB
rs1001797559 -- 27,497,146(+) TGTAA(A/G)TCCAA intron-variant, upstream-variant-2KB
rs1002560298 -- 27,496,293(+) GGGCA(G/T)ATTCT upstream-variant-2KB
rs1002694619 -- 27,495,977(+) CACTA(C/T)GTGAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FNDC4 Gene

Variant ID Type Subtype PubMed ID
nsv817684 CNV gain 17921354

Variation tolerance for FNDC4 Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FNDC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNDC4 Gene

Disorders for FNDC4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FNDC4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fuchs' endothelial dystrophy
  • fced
- elite association - COSMIC cancer census association via MalaCards
Search FNDC4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FNDC4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FNDC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FNDC4 Gene

Publications for FNDC4 Gene

  1. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PMID: 22267201) Stolk L … Lunetta KL (Nature genetics 2012) 3 45 60
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for FNDC4 Gene

Sources for FNDC4 Gene

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