FNDC4 Gene
protein-coding GIFtS: 45
GCID: GC02M027714
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|
fibronectin type III domain containing 4
| |
Aliases
for FNDC4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fibronectin Type III Domain Containing 41 2 | | FRCP11 2 3 5 | | Fibronectin Type III Repeat-Containing Protein 12 3 | | FLJ223621 | | Fibronectin Type III Domain-Containing Protein 42 |
Export aliases for FNDC4 gene to outside databasesPrevious GC identifers: GC02M027689 GC02M027626 GC02M027568 GC02M027456 |
Summaries
for FNDC4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FNDC4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FNDC4 gene promoter:
CREB deltaCREB LCR-F1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FNDC4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FNDC4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p23.3 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2p23.3FNDC4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M027714: view genomic region
(about GC identifiers)
Start:
|
27,714,750 bp from pter |
End:
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27,718,126 bp from pter |
Size:
|
3,377 bases |
Orientation:
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minus strand |
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Proteins
for FNDC4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FNDC4_HUMAN, Q9H6D8 (See
protein sequence)Recommended Name: Fibronectin type III domain-containing protein 4 precursor Size: 234 amino acids; 25159 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: D6W560Explore the universe of human proteins at neXtProt for FNDC4: NX_Q9H6D8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H6D8
FNDC4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_073734.1
ENSEMBL proteins: ENSP00000264703
Human Recombinant Protein Products for FNDC4:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
FNDC4 for ontologies About GeneDecksing
FNDC4 Antibody Products:
Assay Products for FNDC4: |
Protein
Domains /
Families
for FNDC4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FNDC4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H6D8ProtoNet protein and cluster: Q9H6D8 UniProtKB/Swiss-Prot: FNDC4_HUMAN, Q9H6D8Similarity: Contains 1 fibronectin type-III domain |
Function
for FNDC4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FNDC4 (NM_022823) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FNDC4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNDC4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNDC4 |
|
Pathways & Interactions
for FNDC4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FNDC4
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for FNDC4 (ENSP000002647034) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FNDC4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FNDC4
Search CenterWatch for drugs/clinical trials and news about FNDC4
|
Transcripts
for FNDC4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FNDC4 gene: NM_022823.2 Unigene Cluster for FNDC4: Fibronectin type III domain containing 4 Hs.732184 [show with all ESTs]Unigene Representative Sequence: NM_0228233 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000264703(uc002rkx.3) ENST00000491414 ENST00000476197
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FNDC4 (NM_022823) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FNDC4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNDC4 |
Additional cDNA sequence: AK026015.1 AY358136.1 BC024175.1 BC032725.1 4 DOTS entries: DT.85104159 DT.100780118 DT.100780111 DT.100721280 24/136 AceView cDNA sequences (see all 136): CR599669 CR625278 AK026015 Z44980 NM_022823 AI652866 BM547385 BX449110 BI753191 AI954667 BM923672 CR597122 CF128581 AI380721 BF109870 AY358136 BX282467 CR618216 BQ948274 CR605204 CR620289 BQ014319 Z40716 AA983819
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for FNDC4 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b |
|---|
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| SP1: | | | | | | | - | | | | | | | | - | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | | | | |
ECgene alternative splicing isoforms for FNDC4
|
Expression
for FNDC4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FNDC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCCTCAGG
About this image
See FNDC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FNDC4
SOURCE GeneReport for Unigene cluster: Hs.732184
SABiosciences Custom PCR Arrays for FNDC4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FNDC4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FNDC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FNDC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FNDC4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNDC4 |
Orthologs
for FNDC4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FNDC4 gene from 2/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FNDC41 |
fibronectin type III domain containing 4 |
70.16(n)
71.43(a) |
|
421981 XM_419991.3 XP_419991.3 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC1003321621 |
fibronectin type III domain-containing protein 4-like |
62.4(n)
59.61(a) |
|
100332162 XM_002665135.2 XP_002665181.2 |
ENSEMBL Gene Tree for FNDC4 (if available)
TreeFam Gene Tree for FNDC4 (if available) |
Paralogs
for FNDC4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FNDC4 gene
- FNDC52
1 SIMAP similar gene for FNDC4 using alignment to 1 protein entry: FNDC4_HUMAN:FNDC5
FNDC4 for paralogs About GeneDecksing
|
Genomic Variants
for FNDC4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FNDC4 (27714750 - 27718126 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FNDC4
1 CNV: 9400 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for FNDC4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FNDC4 for disorders About GeneDecksing
OMIM gene information: 611905
OMIM disorders: --
1  disease for FNDC4: About MalaCardskidney disease
Human Genome Epidemiology (HuGE) Navigator: FNDC4 (3 documents)
Export disorders for FNDC4 gene to outside databases
|
Publications
for FNDC4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FNDC4 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with FNDC4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Frcp1 and Frcp2, two novel fibronectin type III repeat containing genes. (PubMed id 12384288)1, 3 Teufel A....Westphal H. (2002)
- Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PubMed id 22267201)1 Stolk L....Lunetta K.L. (2012)
- Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. (PubMed id 20705733)1 O'Seaghdha C.M....KAPttgen A. (2010)
- New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1 KAPttgen A....Fox C.S. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
|
External Searches for FNDC4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FNDC4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FNDC4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FNDC4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FNDC4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FNDC4 gene:
Search GeneIP for patents involving FNDC4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FNDC4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for FNDC4 | | OriGene shRNA RFP for FNDC4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FNDC4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FNDC4 | | | OriGene Protein Over-expression Lysate for FNDC4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FNDC4 | | OriGene 3'-UTR Clone for FNDC4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FNDC4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FNDC4 | | OriGene Custom Protein Services for FNDC4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FNDC4 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FNDC4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FNDC4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FNDC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FNDC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FNDC4 |
| |
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| | | | Search Tocris compounds for FNDC4 |
| |  |  |  |  | | | | |
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 |
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 | | | FNDC4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNDC4 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for FNDC4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNDC4 |
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