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Aliases for FNDC4 Gene

Aliases for FNDC4 Gene

  • Fibronectin Type III Domain Containing 4 2 3 5
  • Fibronectin Type III Repeat-Containing Protein 1 3 4
  • FRCP1 3 4

External Ids for FNDC4 Gene

Previous GeneCards Identifiers for FNDC4 Gene

  • GC02M027689
  • GC02M027626
  • GC02M027568
  • GC02M027714
  • GC02M027456

Summaries for FNDC4 Gene

GeneCards Summary for FNDC4 Gene

FNDC4 (Fibronectin Type III Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is FNDC5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNDC4 Gene

Genomics for FNDC4 Gene

Regulatory Elements for FNDC4 Gene

Promoters for FNDC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FNDC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for FNDC4 Gene

Chromosome:
2
Start:
27,491,883 bp from pter
End:
27,495,296 bp from pter
Size:
3,414 bases
Orientation:
Minus strand

Genomic View for FNDC4 Gene

Genes around FNDC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNDC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNDC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC4 Gene

Proteins for FNDC4 Gene

  • Protein details for FNDC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6D8-FNDC4_HUMAN
    Recommended name:
    Fibronectin type III domain-containing protein 4
    Protein Accession:
    Q9H6D8
    Secondary Accessions:
    • D6W560

    Protein attributes for FNDC4 Gene

    Size:
    234 amino acids
    Molecular mass:
    25159 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FNDC4 Gene

Proteomics data for FNDC4 Gene at MOPED

Post-translational modifications for FNDC4 Gene

  • Glycosylation at Asn 52, Asn 97, and Asn 147
  • Modification sites at PhosphoSitePlus

Other Protein References for FNDC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FNDC4 Gene

Domains & Families for FNDC4 Gene

Gene Families for FNDC4 Gene

Protein Domains for FNDC4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FNDC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6D8

UniProtKB/Swiss-Prot:

FNDC4_HUMAN :
  • Contains 1 fibronectin type-III domain.
Domain:
  • Contains 1 fibronectin type-III domain.
genes like me logo Genes that share domains with FNDC4: view

Function for FNDC4 Gene

genes like me logo Genes that share phenotypes with FNDC4: view

Animal Model Products

miRNA for FNDC4 Gene

miRTarBase miRNAs that target FNDC4

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FNDC4 Gene

Localization for FNDC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNDC4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FNDC4 Gene COMPARTMENTS Subcellular localization image for FNDC4 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FNDC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FNDC4: view

Pathways & Interactions for FNDC4 Gene

SuperPathways for FNDC4 Gene

No Data Available

Interacting Proteins for FNDC4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000264703%0d%0a9606.ENSP00000301788%0d%0a
Selected Interacting proteins: ENSP00000264703 for FNDC4 Gene via STRING

Symbol External ID(s) Details
POLR2G

Gene Ontology (GO) - Biological Process for FNDC4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FNDC4 Gene

Drugs & Compounds for FNDC4 Gene

No Compound Related Data Available

Transcripts for FNDC4 Gene

mRNA/cDNA for FNDC4 Gene

Unigene Clusters for FNDC4 Gene

Fibronectin type III domain containing 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2: -
SP3:
SP4: - -

Relevant External Links for FNDC4 Gene

GeneLoc Exon Structure for
FNDC4
ECgene alternative splicing isoforms for
FNDC4

Expression for FNDC4 Gene

mRNA expression in normal human tissues for FNDC4 Gene

mRNA differential expression in normal tissues according to GTEx for FNDC4 Gene

This gene is overexpressed in Liver (x6.9) and Adrenal Gland (x5.7).

SOURCE GeneReport for Unigene cluster for FNDC4 Gene Hs.732184

genes like me logo Genes that share expression patterns with FNDC4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FNDC4 Gene

Orthologs for FNDC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FNDC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FNDC4 35
  • 99.72 (n)
  • 99.57 (a)
FNDC4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FNDC4 36
  • 95 (a)
OneToOne
FNDC4 35
  • 92 (n)
  • 97.33 (a)
dog
(Canis familiaris)
Mammalia FNDC4 35
  • 92.44 (n)
  • 97.33 (a)
FNDC4 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fndc4 36
  • 96 (a)
OneToOne
Fndc4 35
  • 89.28 (n)
  • 96.48 (a)
Fndc4 16
oppossum
(Monodelphis domestica)
Mammalia FNDC4 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FNDC4 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves FNDC4 35
  • 69.77 (n)
  • 70.7 (a)
FNDC4 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fndc4 35
  • 67.49 (n)
  • 67.98 (a)
zebrafish
(Danio rerio)
Actinopterygii FNDC4 (1 of 2) 36
  • 54 (a)
OneToMany
fndc4a 36
  • 60 (a)
OneToMany
fndc4a 35
  • 66.67 (n)
  • 66.15 (a)
Species with no ortholog for FNDC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FNDC4 Gene

ENSEMBL:
Gene Tree for FNDC4 (if available)
TreeFam:
Gene Tree for FNDC4 (if available)

Paralogs for FNDC4 Gene

Paralogs for FNDC4 Gene

(1) SIMAP similar genes for FNDC4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FNDC4: view

Variants for FNDC4 Gene

Sequence variations from dbSNP and Humsavar for FNDC4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs704795 -- 27,493,627(-) ACCAA(C/T)GGCTT intron-variant
rs780088 -- 27,493,137(+) CCTCC(C/T)GAGTA intron-variant
rs10206760 -- 27,492,985(+) TCCCC(A/G)CTCCA intron-variant
rs41291151 -- 27,492,358(+) GTCTC(A/G)GGCAG utr-variant-3-prime
rs41291153 -- 27,494,708(+) CCTGG(A/C)GATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FNDC4 Gene

Variant ID Type Subtype PubMed ID
nsv817684 CNV Gain 17921354

Variation tolerance for FNDC4 Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FNDC4 Gene

HapMap Linkage Disequilibrium report
FNDC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNDC4 Gene

Disorders for FNDC4 Gene

Relevant External Links for FNDC4

Genetic Association Database (GAD)
FNDC4
Human Genome Epidemiology (HuGE) Navigator
FNDC4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FNDC4

No disorders were found for FNDC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FNDC4 Gene

Publications for FNDC4 Gene

  1. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PMID: 22267201) Stolk L. … Lunetta K.L. (Nat. Genet. 2012) 3 48 67
  2. Frcp1 and Frcp2, two novel fibronectin type III repeat containing genes. (PMID: 12384288) Teufel A. … Westphal H. (Gene 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. (PMID: 25288136) . … Chasman D.I. (Mol. Psychiatry 2015) 3
  5. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. (PMID: 23505323) Weissglas-Volkov D. … Pajukanta P. (J. Med. Genet. 2013) 3

Products for FNDC4 Gene

Sources for FNDC4 Gene

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