Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FNDC3B Gene

Aliases for FNDC3B Gene

  • Fibronectin Type III Domain Containing 3B 2 3 5
  • Factor For Adipocyte Differentiation 104 3 4
  • HCV NS5A-Binding Protein 37 3 4
  • FAD104 3 4
  • Fibronectin Type III Domain-Containing Protein 3B 3
  • YVTM2421 3
  • NS5ABP37 4
  • PRO4979 3

External Ids for FNDC3B Gene

Previous GeneCards Identifiers for FNDC3B Gene

  • GC03P173241
  • GC03P171757
  • GC03P169127

Summaries for FNDC3B Gene

GeneCards Summary for FNDC3B Gene

FNDC3B (Fibronectin Type III Domain Containing 3B) is a Protein Coding gene. Diseases associated with FNDC3B include Urethra Adenocarcinoma and Urethra Clear Cell Adenocarcinoma. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is FNDC3A.

UniProtKB/Swiss-Prot for FNDC3B Gene

  • May be a positive regulator of adipogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNDC3B Gene

Genomics for FNDC3B Gene

Regulatory Elements for FNDC3B Gene

Enhancers for FNDC3B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F172124 1.6 FANTOM5 ENCODE 30.7 +94.4 94397 19.4 MLX FEZF1 DMAP1 YY1 SLC30A9 SP3 NFYC TBX21 MEF2D SSRP1 FNDC3B PLD1 RPS27AP8
GH03F172146 1.5 FANTOM5 ENCODE 29.4 +112.9 112864 11.2 HDGF PKNOX1 CREB3L1 SIN3A FEZF1 ZNF48 YY1 ZNF766 GATA2 FOS FNDC3B PLD1 RPS27AP8
GH03F171827 1.6 FANTOM5 Ensembl ENCODE 23.7 -210.5 -210510 3.4 PKNOX1 MLX WRNIP1 ARID4B YBX1 ZNF48 ZNF2 YY1 ZNF143 KLF7 FNDC3B PLD1 TMEM212
GH03F172071 1.6 FANTOM5 Ensembl ENCODE 23.4 +34.1 34057 3.8 PKNOX1 FEZF1 FOS PAF1 TSHZ1 ZNF623 ZNF610 PBX2 MYNN HMBOX1 FNDC3B PLD1 RPS27AP8
GH03F171824 1.6 FANTOM5 Ensembl ENCODE 22.3 -214.5 -214507 2.2 MLX FEZF1 BRCA1 GATA2 KLF7 FOS MAFF MIER3 RCOR2 MXD3 FNDC3B PLD1 TMEM212
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FNDC3B on UCSC Golden Path with GeneCards custom track

Promoters for FNDC3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FNDC3B Gene

172,039,628 bp from pter
172,401,665 bp from pter
362,038 bases
Plus strand

Genomic View for FNDC3B Gene

Genes around FNDC3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNDC3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNDC3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC3B Gene

Proteins for FNDC3B Gene

  • Protein details for FNDC3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibronectin type III domain-containing protein 3B
    Protein Accession:
    Secondary Accessions:
    • B2RB36
    • B3KXR8
    • D3DNQ7
    • Q5U5T8
    • Q6PIJ3
    • Q6UXG1
    • Q6UXZ5
    • Q8IXB2
    • Q8NBU7
    • Q96D78
    • Q9H5I7
    • Q9NSQ8

    Protein attributes for FNDC3B Gene

    1204 amino acids
    Molecular mass:
    132888 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH12204.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH33635.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ88513.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ88733.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15639.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11480.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FNDC3B Gene


neXtProt entry for FNDC3B Gene

Post-translational modifications for FNDC3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for FNDC3B

No data available for DME Specific Peptides for FNDC3B Gene

Domains & Families for FNDC3B Gene

Gene Families for FNDC3B Gene

Suggested Antigen Peptide Sequences for FNDC3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 9 fibronectin type-III domains.
  • Belongs to the FNDC3 family.
  • Contains 9 fibronectin type-III domains.
  • Belongs to the FNDC3 family.
genes like me logo Genes that share domains with FNDC3B: view

Function for FNDC3B Gene

Molecular function for FNDC3B Gene

UniProtKB/Swiss-Prot Function:
May be a positive regulator of adipogenesis.

Gene Ontology (GO) - Molecular Function for FNDC3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with FNDC3B: view
genes like me logo Genes that share phenotypes with FNDC3B: view

Animal Models for FNDC3B Gene

MGI Knock Outs for FNDC3B:

Animal Model Products

  • Taconic Biosciences Mouse Models for FNDC3B

miRNA for FNDC3B Gene

miRTarBase miRNAs that target FNDC3B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FNDC3B Gene

Localization for FNDC3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNDC3B Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FNDC3B gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 3
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for FNDC3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FNDC3B: view

Pathways & Interactions for FNDC3B Gene

SuperPathways for FNDC3B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FNDC3B Gene


No data available for Pathways by source and SIGNOR curated interactions for FNDC3B Gene

Transcripts for FNDC3B Gene

Unigene Clusters for FNDC3B Gene

Fibronectin type III domain containing 3B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC3B Gene

No ASD Table

Relevant External Links for FNDC3B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FNDC3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FNDC3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FNDC3B Gene

This gene is overexpressed in Placenta (23.9) and Islet of Langerhans (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FNDC3B Gene

Protein tissue co-expression partners for FNDC3B Gene

NURSA nuclear receptor signaling pathways regulating expression of FNDC3B Gene:


SOURCE GeneReport for Unigene cluster for FNDC3B Gene:


mRNA Expression by UniProt/SwissProt for FNDC3B Gene:

Tissue specificity: Predominantly expressed in white adipose tissue (WAT) especially in the stromal vascular cells. Expressed in adipocyte differentiable 3T3-L1 cells but not in the non-adipogenic cell line NIH-3T3. Expression increased in the early stage of adipogenesis.
genes like me logo Genes that share expression patterns with FNDC3B: view

No data available for mRNA differential expression in normal tissues for FNDC3B Gene

Orthologs for FNDC3B Gene

This gene was present in the common ancestor of animals.

Orthologs for FNDC3B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FNDC3B 34 35
  • 99.56 (n)
(Bos Taurus)
Mammalia FNDC3B 34 35
  • 92.19 (n)
(Canis familiaris)
Mammalia FNDC3B 34 35
  • 91.69 (n)
(Mus musculus)
Mammalia Fndc3b 34 16 35
  • 86.71 (n)
(Rattus norvegicus)
Mammalia Fndc3b 34
  • 86.6 (n)
(Ornithorhynchus anatinus)
Mammalia FNDC3B 35
  • 85 (a)
(Monodelphis domestica)
Mammalia FNDC3B 35
  • 81 (a)
(Gallus gallus)
Aves FNDC3B 34 35
  • 79.55 (n)
(Anolis carolinensis)
Reptilia FNDC3B 35
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fndc3b 34
  • 72 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18133 34
(Danio rerio)
Actinopterygii fndc3ba 34 35
  • 68.59 (n)
fndc3bb 35
  • 58 (a)
wufa13e05 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4438 34
fruit fly
(Drosophila melanogaster)
Insecta CG42389 35
  • 19 (a)
(Caenorhabditis elegans)
Secernentea let-805 35
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
Species where no ortholog for FNDC3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FNDC3B Gene

Gene Tree for FNDC3B (if available)
Gene Tree for FNDC3B (if available)

Paralogs for FNDC3B Gene

Paralogs for FNDC3B Gene

(3) SIMAP similar genes for FNDC3B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FNDC3B: view

Variants for FNDC3B Gene

Sequence variations from dbSNP and Humsavar for FNDC3B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_035921 A breast cancer sample
rs10049220 -- 172,262,740(+) TCTGA(A/C)AAAAA intron-variant
rs10222578 -- 172,393,273(+) agtca(A/G)aaact intron-variant
rs1039027 -- 172,247,319(-) TTCAT(C/T)GACAT intron-variant
rs1045838 -- 172,398,458(+) TGTTC(C/T)TTGAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FNDC3B Gene

Variant ID Type Subtype PubMed ID
nsv1118983 CNV deletion 24896259
esv3598664 CNV loss 21293372
esv3598663 CNV loss 21293372
esv3598658 CNV gain 21293372
esv3569117 CNV loss 25503493
esv3569116 CNV loss 25503493
esv3444992 CNV duplication 20981092
esv3410350 CNV insertion 20981092
esv3303105 CNV mobile element insertion 20981092
esv2726212 CNV deletion 23290073
esv2464172 CNV deletion 19546169
esv24577 CNV gain 19812545
esv23444 CNV gain 19812545
esv1000089 CNV insertion 20482838
dgv8729n54 CNV loss 21841781
nsv7356 OTHER inversion 18451855
nsv592517 CNV loss 21841781
nsv592516 CNV loss 21841781
nsv592515 CNV loss 21841781
nsv592514 CNV loss 21841781
nsv592513 CNV loss 21841781
nsv592512 CNV loss 21841781
nsv522798 CNV loss 19592680
nsv514998 CNV gain 21397061
nsv4116 CNV insertion 18451855
nsv1145006 CNV deletion 24896259
nsv1125785 CNV tandem duplication 24896259

Variation tolerance for FNDC3B Gene

Residual Variation Intolerance Score: 7.72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FNDC3B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNDC3B Gene

Disorders for FNDC3B Gene

MalaCards: The human disease database

(3) MalaCards diseases for FNDC3B Gene - From: DISEASES

Disorder Aliases PubMed IDs
urethra adenocarcinoma
  • adenocarcinoma of the urethra
urethra clear cell adenocarcinoma
  • clear cell adenocarcinoma of the urethra
urethral benign neoplasm
  • neoplasm of urethra
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FNDC3B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FNDC3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FNDC3B Gene

Publications for FNDC3B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  3. The novel gene fad104, containing a fibronectin type III domain, has a significant role in adipogenesis. (PMID: 15527760) Tominaga K. … Imagawa M. (FEBS Lett. 2004) 2 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for FNDC3B Gene

Sources for FNDC3B Gene

Loading form....