FNDC3B Gene
protein-coding GIFtS: 47
GCID: GC03P171757
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|
fibronectin type III domain containing 3B
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Aliases
for FNDC3B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fibronectin Type III Domain Containing 3B1 2 | | HCV NS5A-Binding Protein 372 3 | | FAD1041 2 3 5 | | DKFZp762K1371 | | PRO49791 2 | | FLJ233991 | | YVTM24211 2 | | Fibronectin Type III Domain-Containing Protein 3B2 | | Factor For Adipocyte Differentiation 1042 3 | | NS5ABP373 |
Export aliases for FNDC3B gene to outside databasesPrevious GC identifers: GC03P173241 GC03P169127 |
Summaries
for FNDC3B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FND3B_HUMAN, Q53EP0Function: May be a positive regulator of adipogenesis
|
Genomic Views
for FNDC3B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for FNDC3B
Other transcription factors
Search SABiosciences Chromatin IP Primers for FNDC3B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FNDC3B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q26.31 Ensembl cytogenetic band: 3q26.31 HGNC cytogenetic band: 3q26.31FNDC3B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P171757: view genomic region
(about GC identifiers)
Start:
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171,757,418 bp from pter |
End:
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172,119,455 bp from pter |
Size:
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362,038 bases |
Orientation:
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plus strand |
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Proteins
for FNDC3B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FND3B_HUMAN, Q53EP0 (See
protein sequence)Recommended Name: Fibronectin type III domain-containing protein 3B Size: 1204 amino acids; 132888 Da
Subcellular location: Membrane; Single-pass membrane protein (By similarity)
Sequence caution: Sequence=AAH12204.1; Type=Erroneous initiation; Sequence=AAH33635.1; Type=Erroneous initiation;Sequence=AAQ88513.1; Type=Erroneous initiation; Sequence=AAQ88733.1; Type=Erroneous initiation; Sequence=BAB15639.1;Type=Erroneous initiation; Sequence=BAC11480.1; Type=Erroneous initiation;
Secondary accessions: B2RB36 B3KXR8 D3DNQ7 Q5U5T8 Q6PIJ3 Q6UXG1 Q6UXZ5 Q8IXB2 Q8NBU7 Q96D78 Q9H5I7Q9NSQ8Alternative splicing: 3 isoforms: Q53EP0-1 Q53EP0-2 Q53EP0-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FNDC3B: NX_Q53EP0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q53EP0
FNDC3B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001128567.1 NP_073600.3
ENSEMBL proteins: ENSP00000408496 ENSP00000411242 ENSP00000338523 ENSP00000392471 ENSP00000389094 ENSP00000389064 ENSP00000376463
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005783 | endoplasmic reticulum |
IDA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
FNDC3B for ontologies About GeneDecksing
FNDC3B Antibody Products:
Assay Products for FNDC3B: |
Protein
Domains /
Families
for FNDC3B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FNDC3B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q53EP0ProtoNet protein and cluster: Q53EP0 2 Blocks protein families: IPB003529 Long hematopoietin receptor IPB003962 Fibronectin type III repeat signature
UniProtKB/Swiss-Prot: FND3B_HUMAN, Q53EP0Similarity: Belongs to the FNDC3 familySimilarity: Contains 9 fibronectin type-III domains |
Function
for FNDC3B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FND3B_HUMAN, Q53EP0Function: May be a positive regulator of adipogenesis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC3B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC3B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNDC3B |
Animal Models:
Mouse knock-out Fndc3btm1Maim for FNDC3B
4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Fndc3b):
FNDC3B for phenotypes About GeneDecksing
|
Pathways & Interactions
for FNDC3B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FNDC3B
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for FNDC3B (Q53EP03 ENSP000003385234) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045600 | positive regulation of fat cell differentiation |
IEA | -- |
FNDC3B for ontologies About GeneDecksing
|
Drugs & Compounds
for FNDC3B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FNDC3B
Search CenterWatch for drugs/clinical trials and news about FNDC3B / FND3B
|
Transcripts
for FNDC3B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FNDC3B gene (2 alternative transcripts): NM_001135095.1 NM_022763.3 Unigene Cluster for FNDC3B: Fibronectin type III domain containing 3B Hs.159430 [show with all ESTs]Unigene Representative Sequence: NM_02276313 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000421757(uc003fhx.3) ENST00000415807 ENST00000469491(uc003fia.3)
ENST00000336824(uc003fhy.3 uc003fhz.4) ENST00000423424 ENST00000416957
ENST00000478016 ENST00000443501 ENST00000476794 ENST00000483344 ENST00000494000
ENST00000490832 ENST00000392699
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC3B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC3B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FNDC3B (NM_022763) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FNDC3B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNDC3B |
Additional cDNA sequence: AB098597.1 AF543840.1 AK027052.1 AK075220.1 AK092465.1 AK127826.1 AK223599.1 AK314478.1 AL157482.1 AY358146.1 BC012204.1 BC026005.1 BC033635.2 BC039297.1 BX648340.1 BX648415.1 15 DOTS entries: DT.101983557 DT.446465 DT.308741 DT.91926787 DT.95090522 DT.209198 DT.408017 DT.91923061 DT.92048828 DT.91643236 DT.91973000 DT.102837935 DT.120904934 DT.92002036 DT.91828987 24/303 AceView cDNA sequences (see all 303): AI128150 AI264641 CA429754 AI436021 BQ225754 AI949175 R78248 AA318454 AI620092 CB268039 CD631554 BQ641865 BF940322 BG120310 CB163915 AL157482 AK027052 BX094538 W72227 D31249 BU632426 AI417065 AI186663 CB111249
GeneLoc Exon Structure
|
Expression
for FNDC3B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FNDC3B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FNDC3B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FNDC3B
SOURCE GeneReport for Unigene cluster: Hs.159430
UniProtKB/Swiss-Prot: FND3B_HUMAN, Q53EP0Tissue specificity: Predominantly expressed in white adipose tissue (WAT) especially in the stromal vascular cells.Expressed in adipocyte differentiable 3T3-L1 cells but not in the non-adipogenic cell line NIH-3T3. Expressionincreased in the early stage of adipogenesis
SABiosciences Custom PCR Arrays for FNDC3B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FNDC3B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FNDC3B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FNDC3B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FNDC3B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNDC3B |
Orthologs
for FNDC3B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FNDC3B gene from 7/22 species (see all 22) About this table
ENSEMBL Gene Tree for FNDC3B (if available)
TreeFam Gene Tree for FNDC3B (if available) |
Paralogs
for FNDC3B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FNDC3B gene
- FNDC3A2
3 SIMAP similar genes for FNDC3B using alignment to 3 protein entries: FND3B_HUMAN (see all proteins):FNDC3A ROS1 L1CAM
FNDC3B for paralogs About GeneDecksing
|
Genomic Variants
for FNDC3B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FNDC3B (171757418 - 172007418 bp, first 250kb of FNDC3B)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FNDC3B
2 Indels: 68504 63660 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FNDC3B |
|
Disorders
/ Diseases
for FNDC3B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FNDC3B for disorders About GeneDecksing
OMIM gene information: 611909
OMIM disorders: --
2  diseases for FNDC3B: About MalaCardshepatitis b hepatitis
Human Genome Epidemiology (HuGE) Navigator: FNDC3B (2 documents)
Export disorders for FNDC3B gene to outside databases
|
Publications
for FNDC3B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FNDC3B gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with FNDC3B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Activation of multiple cancer pathways and tumor maint enance function of the 3q amplified oncogene FNDC3B. (PubMed id 22510613)1 Cai C....Powers R.S. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (2010)
|
External Searches for FNDC3B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FNDC3B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FNDC3B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FNDC3B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FNDC3B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FNDC3B gene:
Search GeneIP for patents involving FNDC3B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FNDC3B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNDC3B |
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