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FNDC3B Gene

protein-coding   GIFtS: 47
GCID: GC03P171757

Fibronectin Type III Domain Containing 3B

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibronectin Type III Domain Containing 3B1 2     PRO49792
FAD1042 3 5     YVTM24212
Factor For Adipocyte Differentiation 1042 3     Fibronectin Type III Domain-Containing Protein 3B2
HCV NS5A-Binding Protein 372 3     NS5ABP373

External Ids:    HGNC: 246701   Entrez Gene: 647782   Ensembl: ENSG000000754207   OMIM: 6119095   UniProtKB: Q53EP03   

Export aliases for FNDC3B gene to outside databases

Previous GC identifers: GC03P173241 GC03P169127


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FNDC3B Gene:
FNDC3B (fibronectin type III domain containing 3B) is a protein-coding gene. Diseases associated with FNDC3B include keratoconus, and breast and colorectal cancer. An important paralog of this gene is SDK2.

UniProtKB/Swiss-Prot: FND3B_HUMAN, Q53EP0
Function: May be a positive regulator of adipogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for FNDC3B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FNDC3B promoter sequence
   Search Chromatin IP Primers for FNDC3B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FNDC3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.31   Ensembl cytogenetic band:  3q26.31   HGNC cytogenetic band: 3q26.31

FNDC3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FNDC3B gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P171757:  view genomic region     (about GC identifiers)

Start:
171,757,418 bp from pter      End:
172,119,455 bp from pter
Size:
362,038 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FND3B_HUMAN, Q53EP0 (See protein sequence)
Recommended Name: Fibronectin type III domain-containing protein 3B  
Size: 1204 amino acids; 132888 Da
Sequence caution: Sequence=AAH12204.1; Type=Erroneous initiation; Sequence=AAH33635.1; Type=Erroneous initiation;
Sequence=AAQ88513.1; Type=Erroneous initiation; Sequence=AAQ88733.1; Type=Erroneous initiation;
Sequence=BAB15639.1; Type=Erroneous initiation; Sequence=BAC11480.1; Type=Erroneous initiation;
Secondary accessions: B2RB36 B3KXR8 D3DNQ7 Q5U5T8 Q6PIJ3 Q6UXG1 Q6UXZ5 Q8IXB2 Q8NBU7 Q96D78
Q9H5I7 Q9NSQ8
Alternative splicing: 3 isoforms:  Q53EP0-1   Q53EP0-2   Q53EP0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FNDC3B: NX_Q53EP0

Explore proteomics data for FNDC3B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FNDC3B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001128567.1  NP_073600.3  

    ENSEMBL proteins: 
     ENSP00000408496   ENSP00000411242   ENSP00000338523   ENSP00000392471   ENSP00000389094  
     ENSP00000389064   ENSP00000376463  

    FNDC3B Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for FNDC3B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing

    2 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q53EP0

    ProtoNet protein and cluster: Q53EP0

    2 Blocks protein domains:
    IPB003529 Long hematopoietin receptor
    IPB003962 Fibronectin type III repeat signature


    UniProtKB/Swiss-Prot: FND3B_HUMAN, Q53EP0
    Similarity: Belongs to the FNDC3 family
    Similarity: Contains 9 fibronectin type-III domains


    FNDC3B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FND3B_HUMAN, Q53EP0
    Function: May be a positive regulator of adipogenesis

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    FNDC3B for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fndc3b):
     cellular  homeostasis/metabolism  mortality/aging  skeleton 

    FNDC3B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fndc3btm1Maim for FNDC3B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FNDC3B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FNDC3B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FNDC3B

    miRNA
    Products:
        
    miRTarBase miRNAs that target FNDC3B:
    hsa-mir-30a-5p (MIRT028527), hsa-mir-16-5p (MIRT001467), hsa-mir-1 (MIRT023814), hsa-mir-98-5p (MIRT027680), hsa-mir-335-5p (MIRT017981), hsa-mir-26b-5p (MIRT029551), hsa-mir-215-5p (MIRT024780), hsa-mir-155-5p (MIRT020764), hsa-mir-192-5p (MIRT026584), hsa-mir-124-3p (MIRT022697), hsa-mir-25-3p (MIRT050229), hsa-mir-92a-3p (MIRT049179), hsa-mir-143-3p (MIRT003060), hsa-mir-378a-3p (MIRT043898)

    Block miRNA regulation of human, mouse, rat FNDC3B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FNDC3B (see all 119):
    hsa-miR-323-3p hsa-miR-548j hsa-miR-100* hsa-miR-607 hsa-miR-3607-3p hsa-miR-106a hsa-miR-15a hsa-miR-30d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FNDC3B

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FNDC3B (NM_022763)
    Sino Biological Human cDNA Clone for FNDC3B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FNDC3B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNDC3B

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNDC3B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FND3B_HUMAN, Q53EP0: Membrane; Single-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    plasma membrane3
    cytosol1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ----
    GO:0016021integral component of membrane IEA--

    FNDC3B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FNDC3B
    Interactions:

        Search GeneGlobe Interaction Network for FNDC3B

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for FNDC3B (Q53EP03 ENSP000003385234) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIP13Q156453I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045600positive regulation of fat cell differentiation IEA--

    FNDC3B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FNDC3B (FND3B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FNDC3B gene (2 alternative transcripts): 
    NM_001135095.1  NM_022763.3  

    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000421757(uc003fhx.3) ENST00000415807 ENST00000469491(uc003fia.3)
    ENST00000336824(uc003fhy.3 uc003fhz.4) ENST00000423424 ENST00000416957
    ENST00000478016 ENST00000443501 ENST00000476794 ENST00000483344 ENST00000494000
    ENST00000490832 ENST00000392699
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FNDC3B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FNDC3B (see all 119):
    hsa-miR-323-3p hsa-miR-548j hsa-miR-100* hsa-miR-607 hsa-miR-3607-3p hsa-miR-106a hsa-miR-15a hsa-miR-30d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat FNDC3B
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    OriGene ORF clones in mouse, rat for FNDC3B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FNDC3B (NM_022763)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FNDC3B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNDC3B
    Primer
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    OriGene qPCR primer pairs and template standards for FNDC3B
    OriGene qSTAR qPCR primer pairs in human, mouse for FNDC3B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FNDC3B
      QuantiTect SYBR Green Assays in human, mouse, rat FNDC3B
      QuantiFast Probe-based Assays in human, mouse, rat FNDC3B

    Selected AceView cDNA sequences (see all 303):

    AW173154 AW514411 BM830488 AF543840 BM784563 AI949175 AW058617 H89725 
    AA766018 AA318454 BM053035 W76464 D31249 R78248 W72227 CD631556 
    AA443245 CA389683 H43113 AW188894 AA314162 AI074903 BE221859 AI186663 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FNDC3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FNDC3B Expression
    About this image


    FNDC3B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Neural Tube (Nervous System)
             Mesencephalic Floor Plate
     
     Thyroid (Endocrine System)
     
     Smooth Muscle (Muscoskeletal System)
     
     Placenta (Extraembryonic Tissues)
    FNDC3B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FNDC3B Protein Expression

    UniProtKB/Swiss-Prot: FND3B_HUMAN, Q53EP0
    Tissue specificity: Predominantly expressed in white adipose tissue (WAT) especially in the stromal vascular
    cells. Expressed in adipocyte differentiable 3T3-L1 cells but not in the non-adipogenic cell line NIH-3T3.
    Expression increased in the early stage of adipogenesis

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNDC3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FNDC3B gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fndc3b1 , 5 fibronectin type III domain containing 3B1, 5 86.71(n)1
    92.77(a)1
      3 (10.91 cM)5
    720071  NM_173182.21  NP_775274.21 
     274161625 
    chicken
    (Gallus gallus)
    Aves FNDC3B1 fibronectin type III domain containing 3B 79.55(n)
    82.88(a)
      424984  NM_001252324.1  NP_001239253.1 
    lizard
    (Anolis carolinensis)
    Reptilia FNDC3B6
    fibronectin type III domain containing 3B
    79(a)
    1 ↔ 1
    3(6309330-6679012)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.181332 Xenopus laevis transcribed sequence 80.22(n)    BI312417.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa13e052 Transcribed sequence 84.62(n)    57034273 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG423896
    --
    19(a)
    1 → many
    2L(16545033-16662012)
    worm
    (Caenorhabditis elegans)
    Secernentea let-8056
    Protein LET-805, isoform b
    7(a)
    1 → many
    III(2658083-2681111) WBGene00002915


    ENSEMBL Gene Tree for FNDC3B (if available)
    TreeFam Gene Tree for FNDC3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FNDC3B gene
    SDK22  SDK12  DSCAM2  DSCAML12  FNDC3A2  
    3 SIMAP similar genes for FNDC3B using alignment to 3 protein entries:     FND3B_HUMAN (see all proteins):
    FNDC3A    ROS1    L1CAM

    FNDC3B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FNDC3B (see all 7461)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359214
    A breast cancer sample4--see VAR_0359212 P S mis40--------
    rs4889971,2
    C--171755438(+) TGAACA/GAAACT 1 -- us2k13Minor allele frequency- G:0.13NA 124
    rs4898171,2
    C,F--171755508(+) TATAAC/ACCCAG 1 -- us2k17Minor allele frequency- A:0.35NA WA EA 366
    rs1124952581,2
    C,F--171755556(+) AGGAGT/GCTGAG 1 -- us2k13Minor allele frequency- G:0.14NA 124
    rs1502016931,2
    C--171755584(+) AAATG-/AAAAAA 1 -- us2k10--------
    rs130861031,2
    C,F--171755603(+) AACATT/GAAAAA 1 -- us2k1 tfbs38Minor allele frequency- G:0.27NA WA EA 368
    rs5119091,2
    C,F--171755622(+) CCAGGC/TGTGAT 1 -- us2k19Minor allele frequency- T:0.49NA WA CSA EA 370
    rs130638111,2
    C,F--171755700(+) GAAGAC/TGCAGT 1 -- us2k111Minor allele frequency- T:0.29NA WA CSA EA 374
    rs2012061351,2
    C--171755738(+) CCTCA-/GGAAAA 1 -- us2k10--------
    rs5638491,2
    C,F--171755740(+) CTCAGA/GAAAAA 1 -- us2k1 trp36Minor allele frequency- G:0.42NA WA CSA 12

    HapMap Linkage Disequilibrium report for FNDC3B (171757418 - 172007418 bp, first 250kb of FNDC3B)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FNDC3B (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2464172CNV Deletion19546169
    esv2726212CNV Deletion23290073
    nsv4116CNV Insertion18451855
    esv1000089CNV Insertion20482838
    esv267385CNV Insertion20981092
    nsv522798CNV Loss19592680
    esv24577CNV Gain19812545
    nsv877986CNV Gain21882294
    esv23444CNV Gain19812545
    nsv514998CNV Complex21397061

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611909    OMIM disorders: --

    5 diseases for FNDC3B:    
    About MalaCards
    keratoconus    breast and colorectal cancer    hepatitis b    hepatitis
    colorectal cancer


    FNDC3B for disorders           About GeneDecksing

    Genetic Association Database (GAD): FNDC3B
    Human Genome Epidemiology (HuGE) Navigator: FNDC3B (2 documents)

    Export disorders for FNDC3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FNDC3B gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with FNDC3B)
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    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The novel gene fad104, containing a fibronectin type III domain, has a significant role in adipogenesis. (PubMed id 15527760)1, 3 Tominaga K....Imagawa M. (FEBS Lett. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PubMed id 23563607)1 Berndt S.I....Ingelsson E. (Nat. Genet. 2013)
    7. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (PubMed id 23583979)1 den Hoed M....Loos R.J. (Nat. Genet. 2013)
    8. Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. (PubMed id 23291589)1 Lu Y....Wong T.Y. (Nat. Genet. 2013)
    9. Activation of multiple cancer pathways and tumor maintenance function of the 3q amplified oncogene FNDC3B. (PubMed id 22510613)1 Cai C....Powers R.S. (Cell Cycle 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64778 HGNC: 24670 AceView: FAD104 Ensembl:ENSG00000075420 euGenes: HUgn64778
    ECgene: FNDC3B H-InvDB: FNDC3B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FNDC3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FNDC3B gene:
    Search GeneIP for patents involving FNDC3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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