Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FNDC3B Gene

Aliases for FNDC3B Gene

  • Fibronectin Type III Domain Containing 3B 2 3
  • FAD104 3 4 6
  • Factor For Adipocyte Differentiation 104 3 4
  • HCV NS5A-Binding Protein 37 3 4
  • Fibronectin Type III Domain-Containing Protein 3B 3
  • YVTM2421 3
  • NS5ABP37 4
  • PRO4979 3

External Ids for FNDC3B Gene

Previous GeneCards Identifiers for FNDC3B Gene

  • GC03P173241
  • GC03P171757
  • GC03P169127

Summaries for FNDC3B Gene

GeneCards Summary for FNDC3B Gene

FNDC3B (Fibronectin Type III Domain Containing 3B) is a Protein Coding gene. An important paralog of this gene is DSCAML1.

UniProtKB/Swiss-Prot for FNDC3B Gene

  • May be a positive regulator of adipogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNDC3B Gene

Genomics for FNDC3B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FNDC3B Gene

172,039,628 bp from pter
172,401,665 bp from pter
362,038 bases
Plus strand

Genomic View for FNDC3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FNDC3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC3B Gene

No data available for Regulatory Elements for FNDC3B Gene

Proteins for FNDC3B Gene

  • Protein details for FNDC3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibronectin type III domain-containing protein 3B
    Protein Accession:
    Secondary Accessions:
    • B2RB36
    • B3KXR8
    • D3DNQ7
    • Q5U5T8
    • Q6PIJ3
    • Q6UXG1
    • Q6UXZ5
    • Q8IXB2
    • Q8NBU7
    • Q96D78
    • Q9H5I7
    • Q9NSQ8

    Protein attributes for FNDC3B Gene

    1204 amino acids
    Molecular mass:
    132888 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH12204.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH33635.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ88513.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ88733.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15639.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11480.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FNDC3B Gene


neXtProt entry for FNDC3B Gene

Proteomics data for FNDC3B Gene at MOPED

Post-translational modifications for FNDC3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FNDC3B Gene

No data available for DME Specific Peptides for FNDC3B Gene

Domains for FNDC3B Gene

Gene Families for FNDC3B Gene

  • FN3 :Fibronectin type III domain containing

Suggested Antigen Peptide Sequences for FNDC3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q53EP0
  • Contains 9 fibronectin type-III domains.
  • Belongs to the FNDC3 family.
genes like me logo Genes that share domains with FNDC3B: view

Function for FNDC3B Gene

Molecular function for FNDC3B Gene

UniProtKB/Swiss-Prot Function: May be a positive regulator of adipogenesis.

Gene Ontology (GO) - Molecular Function for FNDC3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with FNDC3B: view
genes like me logo Genes that share phenotypes with FNDC3B: view

Animal Models for FNDC3B Gene

MGI Knock Outs for FNDC3B:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FNDC3B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FNDC3B Gene

Localization for FNDC3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNDC3B Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for FNDC3B Gene COMPARTMENTS Subcellular localization image for FNDC3B gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FNDC3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FNDC3B: view

Pathways for FNDC3B Gene

SuperPathways for FNDC3B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FNDC3B Gene


No data available for Pathways by source for FNDC3B Gene

Transcripts for FNDC3B Gene

Unigene Clusters for FNDC3B Gene

Fibronectin type III domain containing 3B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FNDC3B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC3B Gene

No ASD Table

Relevant External Links for FNDC3B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FNDC3B Gene

mRNA expression in normal human tissues for FNDC3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FNDC3B Gene

SOURCE GeneReport for Unigene cluster for FNDC3B Gene Hs.744888

mRNA Expression by UniProt/SwissProt for FNDC3B Gene

Tissue specificity: Predominantly expressed in white adipose tissue (WAT) especially in the stromal vascular cells. Expressed in adipocyte differentiable 3T3-L1 cells but not in the non-adipogenic cell line NIH-3T3. Expression increased in the early stage of adipogenesis.
genes like me logo Genes that share expressions with FNDC3B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FNDC3B Gene

Orthologs for FNDC3B Gene

This gene was present in the common ancestor of animals.

Orthologs for FNDC3B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FNDC3B 35
  • 99.56 (n)
  • 99.5 (a)
  • 100 (a)
(Bos Taurus)
Mammalia FNDC3B 35
  • 92.19 (n)
  • 96.43 (a)
  • 96 (a)
(Canis familiaris)
Mammalia FNDC3B 35
  • 91.69 (n)
  • 96.18 (a)
  • 96 (a)
(Mus musculus)
Mammalia Fndc3b 35
  • 86.71 (n)
  • 92.77 (a)
Fndc3b 16
Fndc3b 36
  • 93 (a)
(Monodelphis domestica)
Mammalia FNDC3B 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia FNDC3B 36
  • 85 (a)
(Rattus norvegicus)
Mammalia Fndc3b 35
  • 86.6 (n)
  • 92.86 (a)
(Gallus gallus)
Aves FNDC3B 35
  • 79.55 (n)
  • 82.88 (a)
  • 82 (a)
(Anolis carolinensis)
Reptilia FNDC3B 36
  • 79 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18133 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fndc3b 35
  • 72 (n)
  • 73.08 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4438 35
(Danio rerio)
Actinopterygii fndc3ba 35
  • 68.59 (n)
  • 69.26 (a)
fndc3ba 36
  • 69 (a)
fndc3bb 36
  • 58 (a)
wufa13e05 35
fruit fly
(Drosophila melanogaster)
Insecta CG42389 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea let-805 36
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
Species with no ortholog for FNDC3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FNDC3B Gene

Gene Tree for FNDC3B (if available)
Gene Tree for FNDC3B (if available)

Paralogs for FNDC3B Gene

Paralogs for FNDC3B Gene

Selected SIMAP similar genes for FNDC3B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FNDC3B: view

Variants for FNDC3B Gene

Sequence variations from dbSNP and Humsavar for FNDC3B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1438 -- 172,054,544(+) GCTGT(A/G)TTGCC intron-variant
rs2431 -- 172,399,317(-) AGATG(C/T)TGCCA utr-variant-3-prime
rs2758 -- 172,310,909(-) GTTTT(A/T)GATGG intron-variant
rs10989 -- 172,399,983(-) CCAAA(A/T)AATGG utr-variant-3-prime
rs12897 -- 172,398,112(+) TGCCT(A/G)TATAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FNDC3B Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855
nsv877986 CNV Gain 21882294
nsv4116 CNV Insertion 18451855
esv1000089 CNV Insertion 20482838
nsv514998 CNV Complex 21397061
esv23444 CNV Gain 19812545
esv267385 CNV Insertion 20981092
esv24577 CNV Gain 19812545
esv2464172 CNV Deletion 19546169
nsv522798 CNV Loss 19592680
esv2726212 CNV Deletion 23290073

Relevant External Links for FNDC3B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNDC3B Gene

Disorders for FNDC3B Gene

Relevant External Links for FNDC3B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FNDC3B: view

No data available for UniProtKB/Swiss-Prot for FNDC3B Gene

Publications for FNDC3B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The novel gene fad104, containing a fibronectin type III domain, has a significant role in adipogenesis. (PMID: 15527760) Tominaga K. … Imagawa M. (FEBS Lett. 2004) 2 3
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4

Products for FNDC3B Gene

  • antibodies-online peptides for FNDC3B
  • antibodies-online antibodies for FNDC3B
  • antibodies-online kits for FNDC3B

Sources for FNDC3B Gene

Back to Top