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Aliases for FNDC3B Gene

Aliases for FNDC3B Gene

  • Fibronectin Type III Domain Containing 3B 2 3 5
  • Factor For Adipocyte Differentiation 104 3 4
  • HCV NS5A-Binding Protein 37 3 4
  • FAD104 3 4
  • YVTM2421 3
  • NS5ABP37 4
  • PRO4979 3

External Ids for FNDC3B Gene

Previous GeneCards Identifiers for FNDC3B Gene

  • GC03P173241
  • GC03P171757
  • GC03P169127

Summaries for FNDC3B Gene

GeneCards Summary for FNDC3B Gene

FNDC3B (Fibronectin Type III Domain Containing 3B) is a Protein Coding gene. Diseases associated with FNDC3B include urethra adenocarcinoma and urethra clear cell adenocarcinoma. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is MYOM1.

UniProtKB/Swiss-Prot for FNDC3B Gene

  • May be a positive regulator of adipogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNDC3B Gene

Genomics for FNDC3B Gene

Regulatory Elements for FNDC3B Gene

Enhancers for FNDC3B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FNDC3B on UCSC Golden Path with GeneCards custom track

Genomic Location for FNDC3B Gene

Chromosome:
3
Start:
172,039,628 bp from pter
End:
172,401,665 bp from pter
Size:
362,038 bases
Orientation:
Plus strand

Genomic View for FNDC3B Gene

Genes around FNDC3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNDC3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNDC3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC3B Gene

Proteins for FNDC3B Gene

  • Protein details for FNDC3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53EP0-FND3B_HUMAN
    Recommended name:
    Fibronectin type III domain-containing protein 3B
    Protein Accession:
    Q53EP0
    Secondary Accessions:
    • B2RB36
    • B3KXR8
    • D3DNQ7
    • Q5U5T8
    • Q6PIJ3
    • Q6UXG1
    • Q6UXZ5
    • Q8IXB2
    • Q8NBU7
    • Q96D78
    • Q9H5I7
    • Q9NSQ8

    Protein attributes for FNDC3B Gene

    Size:
    1204 amino acids
    Molecular mass:
    132888 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH12204.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH33635.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ88513.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ88733.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15639.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11480.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FNDC3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FNDC3B Gene

Proteomics data for FNDC3B Gene at MOPED

Post-translational modifications for FNDC3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FNDC3B Gene

No data available for DME Specific Peptides for FNDC3B Gene

Domains & Families for FNDC3B Gene

Gene Families for FNDC3B Gene

Suggested Antigen Peptide Sequences for FNDC3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53EP0

UniProtKB/Swiss-Prot:

FND3B_HUMAN :
  • Contains 9 fibronectin type-III domains.
  • Belongs to the FNDC3 family.
Domain:
  • Contains 9 fibronectin type-III domains.
Family:
  • Belongs to the FNDC3 family.
genes like me logo Genes that share domains with FNDC3B: view

Function for FNDC3B Gene

Molecular function for FNDC3B Gene

UniProtKB/Swiss-Prot Function:
May be a positive regulator of adipogenesis.
genes like me logo Genes that share phenotypes with FNDC3B: view

Animal Models for FNDC3B Gene

MGI Knock Outs for FNDC3B:

Animal Model Products

  • Taconic Biosciences Mouse Models for FNDC3B

miRNA for FNDC3B Gene

miRTarBase miRNAs that target FNDC3B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FNDC3B Gene

Localization for FNDC3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNDC3B Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FNDC3B Gene COMPARTMENTS Subcellular localization image for FNDC3B gene
Compartment Confidence
endoplasmic reticulum 3
plasma membrane 3
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for FNDC3B Gene

Pathways & Interactions for FNDC3B Gene

SuperPathways for FNDC3B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FNDC3B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FNDC3B Gene

Drugs & Compounds for FNDC3B Gene

No Compound Related Data Available

Transcripts for FNDC3B Gene

Unigene Clusters for FNDC3B Gene

Fibronectin type III domain containing 3B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC3B Gene

No ASD Table

Relevant External Links for FNDC3B Gene

GeneLoc Exon Structure for
FNDC3B
ECgene alternative splicing isoforms for
FNDC3B

Expression for FNDC3B Gene

mRNA expression in normal human tissues for FNDC3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FNDC3B Gene

This gene is overexpressed in Placenta (23.9) and Islet of Langerhans (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FNDC3B Gene



SOURCE GeneReport for Unigene cluster for FNDC3B Gene Hs.744888

mRNA Expression by UniProt/SwissProt for FNDC3B Gene

Q53EP0-FND3B_HUMAN
Tissue specificity: Predominantly expressed in white adipose tissue (WAT) especially in the stromal vascular cells. Expressed in adipocyte differentiable 3T3-L1 cells but not in the non-adipogenic cell line NIH-3T3. Expression increased in the early stage of adipogenesis.
genes like me logo Genes that share expression patterns with FNDC3B: view

Protein tissue co-expression partners for FNDC3B Gene

Primer Products

No data available for mRNA differential expression in normal tissues for FNDC3B Gene

Orthologs for FNDC3B Gene

This gene was present in the common ancestor of animals.

Orthologs for FNDC3B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FNDC3B 35
  • 92.19 (n)
  • 96.43 (a)
FNDC3B 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FNDC3B 35
  • 91.69 (n)
  • 96.18 (a)
FNDC3B 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fndc3b 35
  • 86.71 (n)
  • 92.77 (a)
Fndc3b 16
Fndc3b 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FNDC3B 35
  • 99.56 (n)
  • 99.5 (a)
FNDC3B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fndc3b 35
  • 86.6 (n)
  • 92.86 (a)
oppossum
(Monodelphis domestica)
Mammalia FNDC3B 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FNDC3B 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves FNDC3B 35
  • 79.55 (n)
  • 82.88 (a)
FNDC3B 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FNDC3B 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fndc3b 35
  • 72 (n)
  • 73.08 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18133 35
zebrafish
(Danio rerio)
Actinopterygii fndc3ba 35
  • 68.59 (n)
  • 69.26 (a)
wufa13e05 35
fndc3ba 36
  • 69 (a)
OneToMany
fndc3bb 36
  • 58 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4438 35
fruit fly
(Drosophila melanogaster)
Insecta CG42389 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea let-805 36
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for FNDC3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FNDC3B Gene

ENSEMBL:
Gene Tree for FNDC3B (if available)
TreeFam:
Gene Tree for FNDC3B (if available)

Paralogs for FNDC3B Gene

Paralogs for FNDC3B Gene

(3) SIMAP similar genes for FNDC3B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FNDC3B: view

Variants for FNDC3B Gene

Sequence variations from dbSNP and Humsavar for FNDC3B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs7652177 - 172,251,287(+) GTCAA(C/G)CTACA intron-variant, reference, missense
VAR_035921 A breast cancer sample
rs2276806 - 172,381,028(-) TTTCA(C/T)TGATG reference, missense
rs1438 -- 172,054,544(+) GCTGT(A/G)TTGCC intron-variant
rs2431 -- 172,399,317(-) AGATG(C/T)TGCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FNDC3B Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855
nsv877986 CNV Gain 21882294
nsv4116 CNV Insertion 18451855
esv1000089 CNV Insertion 20482838
nsv514998 CNV Complex 21397061
esv23444 CNV Gain 19812545
esv267385 CNV Insertion 20981092
esv24577 CNV Gain 19812545
esv2464172 CNV Deletion 19546169
nsv522798 CNV Loss 19592680
esv2726212 CNV Deletion 23290073

Variation tolerance for FNDC3B Gene

Residual Variation Intolerance Score: 7.72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FNDC3B Gene

HapMap Linkage Disequilibrium report
FNDC3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNDC3B Gene

Disorders for FNDC3B Gene

MalaCards: The human disease database

(3) MalaCards diseases for FNDC3B Gene - From: DISEASES

Disorder Aliases PubMed IDs
urethra adenocarcinoma
  • adenocarcinoma of the urethra
urethra clear cell adenocarcinoma
  • clear cell adenocarcinoma of the urethra
urethral benign neoplasm
  • neoplasm of urethra
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FNDC3B

Genetic Association Database (GAD)
FNDC3B
Human Genome Epidemiology (HuGE) Navigator
FNDC3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FNDC3B
genes like me logo Genes that share disorders with FNDC3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FNDC3B Gene

Publications for FNDC3B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The novel gene fad104, containing a fibronectin type III domain, has a significant role in adipogenesis. (PMID: 15527760) Tominaga K. … Imagawa M. (FEBS Lett. 2004) 2 3
  3. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3
  4. Fad104, a positive regulator of adipocyte differentiation, suppresses invasion and metastasis of melanoma cells by inhibition of STAT3 activity. (PMID: 25671570) Katoh D. … Imagawa M. (PLoS ONE 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for FNDC3B Gene

Sources for FNDC3B Gene

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