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Aliases for FNDC3A Gene

Aliases for FNDC3A Gene

  • Fibronectin Type III Domain Containing 3A 2 3 5
  • Human Gene Expressed In Odontoblasts 3 4
  • FNDC3 3 4
  • HUGO 3 4
  • Fibronectin Type III Domain Containing 3 2
  • BA203I16.1 3
  • BA203I16.5 3
  • KIAA0970 4

External Ids for FNDC3A Gene

Previous HGNC Symbols for FNDC3A Gene

  • FNDC3

Previous GeneCards Identifiers for FNDC3A Gene

  • GC13P048449
  • GC13P049550
  • GC13P030344

Summaries for FNDC3A Gene

GeneCards Summary for FNDC3A Gene

FNDC3A (Fibronectin Type III Domain Containing 3A) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is MYOM1.

UniProtKB/Swiss-Prot for FNDC3A Gene

  • Mediates spermatid-Sertoli adhesion during spermatogenesis.

Gene Wiki entry for FNDC3A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNDC3A Gene

Genomics for FNDC3A Gene

Regulatory Elements for FNDC3A Gene

Enhancers for FNDC3A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FNDC3A on UCSC Golden Path with GeneCards custom track

Promoters for FNDC3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FNDC3A on UCSC Golden Path with GeneCards custom track

Genomic Location for FNDC3A Gene

48,975,912 bp from pter
49,209,779 bp from pter
233,868 bases
Plus strand

Genomic View for FNDC3A Gene

Genes around FNDC3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNDC3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNDC3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC3A Gene

Proteins for FNDC3A Gene

  • Protein details for FNDC3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibronectin type-III domain-containing protein 3A
    Protein Accession:
    Secondary Accessions:
    • B4DYG1
    • Q5HYC9
    • Q5JVF8
    • Q5JVF9
    • Q6EVH3
    • Q6EVH4
    • Q6N020
    • Q6P9D5
    • Q6ZME4
    • Q9H1W1

    Protein attributes for FNDC3A Gene

    1198 amino acids
    Molecular mass:
    131852 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA76814.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD18784.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FNDC3A Gene

    Alternative splice isoforms for FNDC3A Gene


neXtProt entry for FNDC3A Gene

Proteomics data for FNDC3A Gene at MOPED

Post-translational modifications for FNDC3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FNDC3A Gene

No data available for DME Specific Peptides for FNDC3A Gene

Domains & Families for FNDC3A Gene

Gene Families for FNDC3A Gene

Protein Domains for FNDC3A Gene

Suggested Antigen Peptide Sequences for FNDC3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 9 fibronectin type-III domains.
  • Belongs to the FNDC3 family.
  • Contains 9 fibronectin type-III domains.
  • Belongs to the FNDC3 family.
genes like me logo Genes that share domains with FNDC3A: view

Function for FNDC3A Gene

Molecular function for FNDC3A Gene

UniProtKB/Swiss-Prot Function:
Mediates spermatid-Sertoli adhesion during spermatogenesis.
genes like me logo Genes that share phenotypes with FNDC3A: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FNDC3A Gene

Localization for FNDC3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNDC3A Gene

Golgi apparatus membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for FNDC3A Gene COMPARTMENTS Subcellular localization image for FNDC3A gene
Compartment Confidence
golgi apparatus 5
cytosol 3
endoplasmic reticulum 3
plasma membrane 3
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FNDC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005829 cytosol IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FNDC3A: view

Pathways & Interactions for FNDC3A Gene

SuperPathways for FNDC3A Gene

No Data Available

Interacting Proteins for FNDC3A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000417257 for FNDC3A Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FNDC3A Gene


No data available for Pathways by source and SIGNOR curated interactions for FNDC3A Gene

Drugs & Compounds for FNDC3A Gene

No Compound Related Data Available

Transcripts for FNDC3A Gene

Unigene Clusters for FNDC3A Gene

Fibronectin type III domain containing 3A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC3A Gene

No ASD Table

Relevant External Links for FNDC3A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FNDC3A Gene

mRNA expression in normal human tissues for FNDC3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FNDC3A Gene

This gene is overexpressed in Placenta (18.8) and Stomach (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FNDC3A Gene

SOURCE GeneReport for Unigene cluster for FNDC3A Gene Hs.508010

mRNA Expression by UniProt/SwissProt for FNDC3A Gene

Tissue specificity: Expressed in the odontoblast and nerves in the dental pulp. Also expressed in trachea and to a lesser extent in the brain, liver, lung and kidney.
genes like me logo Genes that share expression patterns with FNDC3A: view

Protein tissue co-expression partners for FNDC3A Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for FNDC3A Gene

Orthologs for FNDC3A Gene

This gene was present in the common ancestor of animals.

Orthologs for FNDC3A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FNDC3A 35
  • 92.79 (n)
  • 94.24 (a)
  • 94 (a)
(Canis familiaris)
Mammalia FNDC3A 35
  • 93.91 (n)
  • 95.41 (a)
  • 94 (a)
(Mus musculus)
Mammalia Fndc3a 35
  • 88.45 (n)
  • 91.07 (a)
Fndc3a 16
Fndc3a 36
  • 91 (a)
(Pan troglodytes)
Mammalia FNDC3A 35
  • 99.81 (n)
  • 99.75 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Fndc3a 35
  • 87.88 (n)
  • 90.89 (a)
(Monodelphis domestica)
Mammalia FNDC3A 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia FNDC3A 36
  • 86 (a)
(Gallus gallus)
Aves FNDC3A 35
  • 80.37 (n)
  • 80.03 (a)
  • 80 (a)
(Anolis carolinensis)
Reptilia FNDC3A 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492173 35
  • 73.95 (n)
  • 73.64 (a)
Str.15243 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.21668 35
(Danio rerio)
Actinopterygii FNDC3A 36
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009522 35
  • 25.26 (n)
  • 9.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42389 35
  • 44.57 (n)
  • 36.71 (a)
CG42389 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea let-805 36
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for FNDC3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FNDC3A Gene

Gene Tree for FNDC3A (if available)
Gene Tree for FNDC3A (if available)

Paralogs for FNDC3A Gene

Paralogs for FNDC3A Gene

(2) SIMAP similar genes for FNDC3A Gene using alignment to 3 proteins: Pseudogenes for FNDC3A Gene

genes like me logo Genes that share paralogs with FNDC3A: view

Variants for FNDC3A Gene

Sequence variations from dbSNP and Humsavar for FNDC3A Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs34539036 - 49,131,203(+) CTGGT(A/G)GTCAC nc-transcript-variant, reference, missense
rs8248 -- 48,975,435(+) GGGTT(C/G)GAAGT upstream-variant-2KB
rs928039 -- 48,979,992(-) CAAGA(A/C)ATTTC intron-variant
rs716722 -- 49,178,942(+) GGCTG(A/G)TCTCA intron-variant
rs728075 -- 48,999,087(-) TGCTG(C/T)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FNDC3A Gene

Variant ID Type Subtype PubMed ID
nsv1034 CNV Loss 18451855
nsv455882 CNV Loss 19166990
dgv1585n71 CNV Loss 21882294
nsv1035 CNV Loss 18451855
nsv1036 CNV Insertion 18451855
nsv832607 CNV Loss 17160897

Variation tolerance for FNDC3A Gene

Residual Variation Intolerance Score: 5.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.04; 60.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FNDC3A Gene

Disorders for FNDC3A Gene

Relevant External Links for FNDC3A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FNDC3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FNDC3A Gene

Publications for FNDC3A Gene

  1. HUGO (FNDC3A): a new gene overexpressed in human odontoblasts. (PMID: 18218838) Carrouel F. … Bleicher F. (J. Dent. Res. 2008) 3 4 67
  2. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for FNDC3A Gene

Sources for FNDC3A Gene