Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FNDC3A Gene

Aliases for FNDC3A Gene

  • Fibronectin Type III Domain Containing 3A 2 3
  • Human Gene Expressed In Odontoblasts 3 4
  • FNDC3 3 4
  • HUGO 3 4
  • Fibronectin Type-III Domain-Containing Protein 3A 3
  • Fibronectin Type III Domain Containing 3 2
  • BA203I16.1 3
  • BA203I16.5 3
  • KIAA0970 4

External Ids for FNDC3A Gene

Previous HGNC Symbols for FNDC3A Gene

  • FNDC3

Previous GeneCards Identifiers for FNDC3A Gene

  • GC13P048449
  • GC13P049550
  • GC13P030344

Summaries for FNDC3A Gene

GeneCards Summary for FNDC3A Gene

FNDC3A (Fibronectin Type III Domain Containing 3A) is a Protein Coding gene. An important paralog of this gene is DSCAML1.

UniProtKB/Swiss-Prot for FNDC3A Gene

  • Mediates spermatid-Sertoli adhesion during spermatogenesis.

Gene Wiki entry for FNDC3A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNDC3A Gene

Genomics for FNDC3A Gene

Regulatory Elements for FNDC3A Gene

Genomic Location for FNDC3A Gene

Start:
48,975,912 bp from pter
End:
49,209,779 bp from pter
Size:
233,868 bases
Orientation:
Plus strand

Genomic View for FNDC3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FNDC3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC3A Gene

Proteins for FNDC3A Gene

  • Protein details for FNDC3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2H6-FND3A_HUMAN
    Recommended name:
    Fibronectin type-III domain-containing protein 3A
    Protein Accession:
    Q9Y2H6
    Secondary Accessions:
    • B4DYG1
    • Q5HYC9
    • Q5JVF8
    • Q5JVF9
    • Q6EVH3
    • Q6EVH4
    • Q6N020
    • Q6P9D5
    • Q6ZME4
    • Q9H1W1

    Protein attributes for FNDC3A Gene

    Size:
    1198 amino acids
    Molecular mass:
    131852 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76814.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD18784.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FNDC3A Gene

    Alternative splice isoforms for FNDC3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FNDC3A Gene

Proteomics data for FNDC3A Gene at MOPED

Post-translational modifications for FNDC3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FNDC3A Gene

No data available for DME Specific Peptides for FNDC3A Gene

Domains for FNDC3A Gene

Gene Families for FNDC3A Gene

HGNC:
  • FN3 :Fibronectin type III domain containing

Protein Domains for FNDC3A Gene

Suggested Antigen Peptide Sequences for FNDC3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2H6

UniProtKB/Swiss-Prot:

FND3A_HUMAN :
  • Q9Y2H6
Domain:
  • Contains 9 fibronectin type-III domains.
Family:
  • Belongs to the FNDC3 family.
genes like me logo Genes that share domains with FNDC3A: view

Function for FNDC3A Gene

Molecular function for FNDC3A Gene

UniProtKB/Swiss-Prot Function:
Mediates spermatid-Sertoli adhesion during spermatogenesis.

Gene Ontology (GO) - Molecular Function for FNDC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with FNDC3A: view

Phenotypes for FNDC3A Gene

genes like me logo Genes that share phenotypes with FNDC3A: view

Animal Model Products

miRNA for FNDC3A Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FNDC3A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FNDC3A Gene

Localization for FNDC3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNDC3A Gene

Golgi apparatus membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FNDC3A Gene COMPARTMENTS Subcellular localization image for FNDC3A gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
cytosol 2
endoplasmic reticulum 2
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FNDC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0001669 acrosomal vesicle IEA --
GO:0005794 Golgi apparatus IDA 18218838
GO:0005829 cytosol IEA --
GO:0012506 vesicle membrane IEA --
genes like me logo Genes that share ontologies with FNDC3A: view

Pathways for FNDC3A Gene

SuperPathways for FNDC3A Gene

No Data Available

Interacting Proteins for FNDC3A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000417257%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000417257 for FNDC3A Gene via STRING

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for FNDC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007286 spermatid development IEA --
GO:0009566 fertilization IEA --
GO:0016337 single organismal cell-cell adhesion IEA --
GO:0060009 Sertoli cell development IEA --
genes like me logo Genes that share ontologies with FNDC3A: view

No data available for Pathways by source for FNDC3A Gene

Transcripts for FNDC3A Gene

Unigene Clusters for FNDC3A Gene

Fibronectin type III domain containing 3A:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FNDC3A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC3A Gene

No ASD Table

Relevant External Links for FNDC3A Gene

GeneLoc Exon Structure for
FNDC3A
ECgene alternative splicing isoforms for
FNDC3A

Expression for FNDC3A Gene

mRNA expression in normal human tissues for FNDC3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for FNDC3A Gene

This gene is overexpressed in Placenta (18.8) and Stomach (8.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FNDC3A Gene

SOURCE GeneReport for Unigene cluster for FNDC3A Gene Hs.508010

mRNA Expression by UniProt/SwissProt for FNDC3A Gene

Q9Y2H6-FND3A_HUMAN
Tissue specificity: Expressed in the odontoblast and nerves in the dental pulp. Also expressed in trachea and to a lesser extent in the brain, liver, lung and kidney.
genes like me logo Genes that share expressions with FNDC3A: view

Expression partners for FNDC3A Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FNDC3A Gene

Orthologs for FNDC3A Gene

This gene was present in the common ancestor of animals.

Orthologs for FNDC3A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FNDC3A 35
  • 92.79 (n)
  • 94.24 (a)
FNDC3A 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FNDC3A 35
  • 93.91 (n)
  • 95.41 (a)
FNDC3A 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fndc3a 35
  • 88.45 (n)
  • 91.07 (a)
Fndc3a 16
Fndc3a 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FNDC3A 35
  • 99.81 (n)
  • 99.75 (a)
FNDC3A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fndc3a 35
  • 87.88 (n)
  • 90.89 (a)
oppossum
(Monodelphis domestica)
Mammalia FNDC3A 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FNDC3A 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves FNDC3A 35
  • 80.37 (n)
  • 80.03 (a)
FNDC3A 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FNDC3A 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492173 35
  • 73.95 (n)
  • 73.64 (a)
Str.15243 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.21668 35
zebrafish
(Danio rerio)
Actinopterygii FNDC3A 36
  • 52 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009522 35
  • 25.26 (n)
  • 9.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42389 35
  • 44.57 (n)
  • 36.71 (a)
CG42389 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea let-805 36
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for FNDC3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FNDC3A Gene

ENSEMBL:
Gene Tree for FNDC3A (if available)
TreeFam:
Gene Tree for FNDC3A (if available)

Paralogs for FNDC3A Gene

Paralogs for FNDC3A Gene

Selected SIMAP similar genes for FNDC3A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for FNDC3A Gene

genes like me logo Genes that share paralogs with FNDC3A: view

Variants for FNDC3A Gene

Sequence variations from dbSNP and Humsavar for FNDC3A Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs8248 -- 48,975,435(+) GGGTT(C/G)GAAGT upstream-variant-2KB
rs716722 -- 49,178,942(+) GGCTG(A/G)TCTCA intron-variant
rs728075 -- 48,999,087(-) TGCTG(C/T)GGGGC intron-variant
rs736222 -- 49,202,204(+) ATAAT(G/T)TAGCA intron-variant
rs928039 -- 48,979,992(-) CAAGA(A/C)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FNDC3A Gene

Variant ID Type Subtype PubMed ID
nsv1034 CNV Loss 18451855
nsv455882 CNV Loss 19166990
dgv1585n71 CNV Loss 21882294
nsv1035 CNV Loss 18451855
nsv1036 CNV Insertion 18451855
nsv832607 CNV Loss 17160897

Relevant External Links for FNDC3A Gene

HapMap Linkage Disequilibrium report
FNDC3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNDC3A Gene

Disorders for FNDC3A Gene

Relevant External Links for FNDC3A

Genetic Association Database (GAD)
FNDC3A
Human Genome Epidemiology (HuGE) Navigator
FNDC3A

No disorders were found for FNDC3A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FNDC3A Gene

Publications for FNDC3A Gene

  1. HUGO (FNDC3A): a new gene overexpressed in human odontoblasts. (PMID: 18218838) Carrouel F. … Bleicher F. (J. Dent. Res. 2008) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for FNDC3A Gene

Sources for FNDC3A Gene

Back to Top

Content