FNDC3A Gene
protein-coding GIFtS: 46
GCID: GC13P049550
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fibronectin type III domain containing 3A(Previous name: fibronectin type III domain containing 3 )
(Previous symbol: FNDC3)
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Aliases
for FNDC3A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fibronectin Type III Domain Containing 3A1 2 | | HUGO2 3 | | FNDC31 2 3 | | Fibronectin Type III Domain Containing 31 | | BA203I16.51 | | BA203I16.11 | | KIAA09701 3 | | Fibronectin Type-III Domain-Containing Protein 3A2 | | Human Gene Expressed In Odontoblasts2 3 | | |
Export aliases for FNDC3A gene to outside databasesPrevious GC identifers: GC13P048449 GC13P030344 |
Summaries
for FNDC3A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FND3A_HUMAN, Q9Y2H6Function: Mediates spermatid-Sertoli adhesion during spermatogenesis (By similarity)
Gene Wiki entry for FNDC3A
|
Genomic Views
for FNDC3A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FNDC3A gene promoter:
E2F-4 E2F-3a E2F-5 AP-1 E2F-2 Nkx2-5 E2F E2F-1 FOXC1 ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for FNDC3A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FNDC3A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q14.2 Ensembl cytogenetic band: 13q14.2 HGNC cytogenetic band: 13q14.12FNDC3A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P049550: view genomic region
(about GC identifiers)
Start:
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49,550,048 bp from pter |
End:
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49,783,915 bp from pter |
Size:
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233,868 bases |
Orientation:
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plus strand |
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Proteins
for FNDC3A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FND3A_HUMAN, Q9Y2H6 (See
protein sequence)Recommended Name: Fibronectin type-III domain-containing protein 3A Size: 1198 amino acids; 131852 Da
Subcellular location: Golgi apparatus membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=BAA76814.2; Type=Erroneous initiation; Sequence=BAD18784.1; Type=Erroneous initiation;
6 PDB 3D structures from  and Proteopedia  for FNDC3A:1WK0 (3D)
1X3D (3D)
1X4X (3D)
1X5X (3D)
2CRM (3D)
2CRZ (3D)
Secondary accessions: B4DYG1 Q5HYC9 Q5JVF8 Q5JVF9 Q6EVH3 Q6EVH4 Q6N020 Q6P9D5 Q6ZME4 Q9H1W1Alternative promoter usage: 2 isoforms: Q9Y2H6-1 Q9Y2H6-2 Explore the universe of human proteins at neXtProt for FNDC3A: NX_Q9Y2H6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y2H6
FNDC3A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001073141.1 NP_055738.3
ENSEMBL proteins: ENSP00000417257 ENSP00000420275 ENSP00000338579 ENSP00000381362 ENSP00000418703 ENSP00000441831
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
FNDC3A for ontologies About GeneDecksing
FNDC3A Antibody Products:
Assay Products for FNDC3A: |
Protein
Domains /
Families
for FNDC3A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FNDC3A for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y2H6ProtoNet protein and cluster: Q9Y2H6 1 Blocks protein family: IPB003962 Fibronectin type III repeat signature
UniProtKB/Swiss-Prot: FND3A_HUMAN, Q9Y2H6Similarity: Belongs to the FNDC3 familySimilarity: Contains 9 fibronectin type-III domains |
Function
for FNDC3A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FND3A_HUMAN, Q9Y2H6Function: Mediates spermatid-Sertoli adhesion during spermatogenesis (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC3A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC3A (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNDC3A |
Animal Models:
2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Fndc3a):
FNDC3A for phenotypes About GeneDecksing
|
Pathways & Interactions
for FNDC3A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FNDC3A
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for FNDC3A (ENSP000004172574) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
FNDC3A for ontologies About GeneDecksing
|
Drugs & Compounds
for FNDC3A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FNDC3A
Search CenterWatch for drugs/clinical trials and news about FNDC3A / FND3A
|
Transcripts
for FNDC3A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FNDC3A gene (2 alternative transcripts): NM_001079673.1 NM_014923.3 Unigene Cluster for FNDC3A: Fibronectin type III domain containing 3A Hs.508010 [show with all ESTs]Unigene Representative Sequence: NM_0010796737 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000492622 ENST00000378383(uc001vcl.1) ENST00000484074 ENST00000337156(uc001vcm.3 uc001vcn.3 uc001vco.3 uc001vcq.3)
ENST00000398316(uc001vcp.1) ENST00000497644 ENST00000541916
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC3A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC3A (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FNDC3A (NM_014923) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FNDC3A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNDC3A |
Additional cDNA sequence: AB023187.2 AJ749706.1 AJ749707.1 AK001140.1 AK056071.1 AK172814.1 AK302415.1 BC036010.1 BC051029.1 BC060816.1 BC070072.1 BC107793.1 BC132812.1 BC136617.1 BC144301.1 BX640739.1 BX648141.1 BX648706.1 19 DOTS entries: DT.443342 DT.100726866 DT.40267652 DT.40309552 DT.99944889 DT.120764342 DT.208738 DT.100787612 DT.75128924 DT.95303881 DT.97806585 DT.100787609 DT.120764407 DT.75133740 DT.95074811 DT.120764436 DT.204793 DT.213603 DT.95074804 24/363 AceView cDNA sequences (see all 363): BE048717 AJ749707 BX108961 AU137609 AA361239 BM744010 BU950172 AA922947 BG778950 BM504778 CK430522 BI712828 BC060816 AI679618 AA932204 AI888010 BM738081 BM673599 AL118569 AI373318 AI433872 BC070072 AA922946 AI091442
GeneLoc Exon Structure
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Expression
for FNDC3A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FNDC3A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAATAAAA
About this image
See FNDC3A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FNDC3A
SOURCE GeneReport for Unigene cluster: Hs.508010
UniProtKB/Swiss-Prot: FND3A_HUMAN, Q9Y2H6Tissue specificity: Expressed in the odontoblast and nerves in the dental pulp. Also expressed in trachea and to alesser extent in the brain, liver, lung and kidney
SABiosciences Custom PCR Arrays for FNDC3A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FNDC3A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FNDC3A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FNDC3A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FNDC3A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNDC3A |
Orthologs
for FNDC3A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FNDC3A gene from 6/23 species (see all 23) About this table
ENSEMBL Gene Tree for FNDC3A (if available)
TreeFam Gene Tree for FNDC3A (if available) |
Paralogs
for FNDC3A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FNDC3A gene
- FNDC3B2
2 SIMAP similar genes for FNDC3A using alignment to 3 protein entries: FND3A_HUMAN (see all proteins):FNDC3B ROS1
FNDC3A for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for FNDC3A
PGOHUM00000240270 PGOHUM00000241407
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Genomic Variants
for FNDC3A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for FNDC3A (49550048 - 49783915 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FNDC3A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FNDC3A |
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Disorders
/ Diseases
for FNDC3A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 FNDC3A for disorders About MalaCards
FNDC3A for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: FNDC3A (1 document)
Export disorders for FNDC3A gene to outside databases
|
Publications
for FNDC3A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FNDC3A gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with FNDC3A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- HUGO (FNDC3A): a new gene overexpressed in human odontoblasts. (PubMed id 18218838)1, 2 Carrouel F....Bleicher F. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
- Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (1999)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
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External Searches for FNDC3A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing FNDC3A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FNDC3A gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FNDC3A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FNDC3A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FNDC3A gene:
Search GeneIP for patents involving FNDC3A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FNDC3A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FNDC3A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FNDC3A | | | OriGene Protein Over-expression Lysate for FNDC3A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FNDC3A | | OriGene 3'-UTR Clone for FNDC3A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC3A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC3A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FNDC3A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FNDC3A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FNDC3A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FNDC3A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FNDC3A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FNDC3A |
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 | | | FNDC3A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNDC3A |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNDC3A |
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