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Aliases for FNDC11 Gene

Aliases for FNDC11 Gene

  • Fibronectin Type III Domain Containing 11 2 3 5
  • C20orf195 3 4
  • Fibronectin Type III Domain-Containing Protein 11 3
  • Chromosome 20 Open Reading Frame 195 2
  • Uncharacterized Protein C20orf195 3

External Ids for FNDC11 Gene

Previous HGNC Symbols for FNDC11 Gene

  • C20orf195

Summaries for FNDC11 Gene

GeneCards Summary for FNDC11 Gene

FNDC11 (Fibronectin Type III Domain Containing 11) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNDC11 Gene

Genomics for FNDC11 Gene

Regulatory Elements for FNDC11 Gene

Enhancers for FNDC11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G063893 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +348.8 348801 5.4 HDGF FOXA2 PKNOX1 ARNT MLX AGO1 WRNIP1 SIN3A ARID4B DMAP1 UCKL1 MIR647 GMEB2 PRPF6 RGS19 RTEL1 OPRL1 ZBTB46 C20orf181 SRMS
GH20G063611 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12 +64.8 64834 1.6 CTCF TFAP4 SAP130 MAX ZNF644 RAD21 TEAD3 RARA NR2F6 GATAD2A FNDC11 SRMS PTK6 STMN3 RGS19 LIME1 OPRL1 GMEB2 HELZ2 TPD52L2
GH20G063680 1.5 Ensembl ENCODE dbSUPER 11.5 +139.4 139412 13.3 HDGF PKNOX1 AGO1 ZFP64 SIN3A ZBTB7B ZNF548 FOS DEK ZNF263 LIME1 RTEL1 MIR647 UCKL1 ENSG00000237371 ZGPAT SLC2A4RG ENSG00000229299 SRMS FNDC11
GH20G063902 1.4 Ensembl ENCODE dbSUPER 11.3 +355.6 355609 2.2 HDGF ATF1 PKNOX1 TCF12 GLIS2 ZNF592 MBD2 SMARCA4 MYNN GLIS1 FNDC11 SRMS ZBTB46 ZBTB46-AS1 ENSG00000229299 C20orf181 OPRL1 RGS19 LKAAEAR1 MIR941-1
GH20G063872 1.3 Ensembl ENCODE dbSUPER 10.8 +325.9 325898 2.2 CTCF JUN ZSCAN4 MAX YBX1 RAD21 HIC1 ZNF316 FOXK2 FOS DNAJC5 C20orf181 MIR647 UCKL1 ZBTB46 ZBTB46-AS1 RNU1-134P FNDC11 SRMS TPD52L2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FNDC11 on UCSC Golden Path with GeneCards custom track

Genomic Location for FNDC11 Gene

Chromosome:
20
Start:
63,547,891 bp from pter
End:
63,556,708 bp from pter
Size:
8,818 bases
Orientation:
Plus strand

Genomic View for FNDC11 Gene

Genes around FNDC11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNDC11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNDC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC11 Gene

Proteins for FNDC11 Gene

  • Protein details for FNDC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVV2-FND11_HUMAN
    Recommended name:
    Fibronectin type III domain-containing protein 11
    Protein Accession:
    Q9BVV2

    Protein attributes for FNDC11 Gene

    Size:
    318 amino acids
    Molecular mass:
    36526 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FNDC11 Gene

Post-translational modifications for FNDC11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FNDC11 Gene

No data available for DME Specific Peptides for FNDC11 Gene

Domains & Families for FNDC11 Gene

Protein Domains for FNDC11 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FNDC11: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for FNDC11 Gene

Function for FNDC11 Gene

Gene Ontology (GO) - Molecular Function for FNDC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with FNDC11: view
genes like me logo Genes that share phenotypes with FNDC11: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FNDC11 Gene

Localization for FNDC11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FNDC11 gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FNDC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FNDC11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FNDC11 Gene

Pathways & Interactions for FNDC11 Gene

SuperPathways for FNDC11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FNDC11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FNDC11 Gene

Transcripts for FNDC11 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC11 Gene

No ASD Table

Relevant External Links for FNDC11 Gene

GeneLoc Exon Structure for
FNDC11
ECgene alternative splicing isoforms for
FNDC11

Expression for FNDC11 Gene

NURSA nuclear receptor signaling pathways regulating expression of FNDC11 Gene:

FNDC11
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FNDC11 Gene

Orthologs for FNDC11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FNDC11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C20orf195 35
  • 99 (a)
OneToOne
C20H20orf195 34
  • 98.64 (n)
dog
(Canis familiaris)
Mammalia C24H20orf195 34
  • 86.35 (n)
C20orf195 35
  • 58 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C13H20orf195 34
  • 86.14 (n)
C20orf195 35
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC051628 34 35
  • 83.07 (n)
Fndc11 16
rat
(Rattus norvegicus)
Mammalia RGD1564340 34
  • 82.33 (n)
chicken
(Gallus gallus)
Aves C20H20ORF195 34
  • 57.38 (n)
C20orf195 35
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C20orf195 35
  • 56 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2493 34
Species where no ortholog for FNDC11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FNDC11 Gene

ENSEMBL:
Gene Tree for FNDC11 (if available)
TreeFam:
Gene Tree for FNDC11 (if available)

Paralogs for FNDC11 Gene

No data available for Paralogs for FNDC11 Gene

Variants for FNDC11 Gene

Sequence variations from dbSNP and Humsavar for FNDC11 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000149258 -- 63,552,534(+) GCTCT(A/G)CCCCC upstream-variant-2KB
rs1001302991 -- 63,551,889(+) GACTA(C/T)AGGCG upstream-variant-2KB
rs1001338645 -- 63,551,566(+) AAGTA(A/G)AAGTT upstream-variant-2KB
rs1002185245 -- 63,553,757(+) CCAGG(A/C)GCTGG intron-variant, upstream-variant-2KB
rs1003199331 -- 63,554,885(+) GCTGC(A/G/T)GCAGA intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FNDC11 Gene

Variant ID Type Subtype PubMed ID
dgv35n64 CNV loss 17921354
dgv521n27 CNV loss 19166990
dgv522n27 CNV loss 19166990
dgv7667n54 CNV loss 21841781
dgv7668n54 CNV loss 21841781
esv2722935 CNV deletion 23290073
esv2758806 CNV gain+loss 17122850
nsv470563 CNV loss 18288195
nsv517702 CNV loss 19592680
nsv521734 CNV loss 19592680
nsv586571 CNV loss 21841781
nsv586573 CNV loss 21841781
nsv834033 CNV gain 17160897
nsv834034 CNV loss 17160897
nsv953306 CNV deletion 24416366
nsv9825 CNV gain 18304495

Variation tolerance for FNDC11 Gene

Residual Variation Intolerance Score: 15.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FNDC11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FNDC11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNDC11 Gene

Disorders for FNDC11 Gene

Relevant External Links for FNDC11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FNDC11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FNDC11

No disorders were found for FNDC11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FNDC11 Gene

Publications for FNDC11 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for FNDC11 Gene

Sources for FNDC11 Gene

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