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Aliases for FNDC11 Gene

Aliases for FNDC11 Gene

  • Fibronectin Type III Domain Containing 11 2 3 5
  • C20orf195 3 4
  • Fibronectin Type III Domain-Containing Protein 11 3
  • Chromosome 20 Open Reading Frame 195 2
  • Uncharacterized Protein C20orf195 3

External Ids for FNDC11 Gene

Previous HGNC Symbols for FNDC11 Gene

  • C20orf195

Summaries for FNDC11 Gene

GeneCards Summary for FNDC11 Gene

FNDC11 (Fibronectin Type III Domain Containing 11) is a Protein Coding gene.

Additional gene information for FNDC11 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNDC11 Gene

Genomics for FNDC11 Gene

Regulatory Elements for FNDC11 Gene

Enhancers for FNDC11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H063536 1.7 FANTOM5 ENCODE dbSUPER 12.8 -10.1 -10101 3.4 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 PPDPF MRGBP GMEB2 PRPF6 FNDC11 PTK6 CICP4 DIDO1 SRMS SAMD10
GH20H063893 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +348.8 348801 5.4 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ZNF143 DIDO1 UCKL1 MIR647 GMEB2 PRPF6 RGS19 RTEL1 OPRL1 ZBTB46 C20orf181
GH20H063831 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +285.6 285635 5 HDGF PKNOX1 ATF1 ZFP64 ARID4B SIN3A BRCA1 ZBTB7B SLC30A9 ZNF766 DIDO1 GMEB2 ENSG00000237371 FNDC11 LIME1 TCFL5 ABHD16B OPRL1 ZBTB46 C20orf181
GH20H062775 1.5 Ensembl ENCODE dbSUPER 12 -771.3 -771338 2.4 HDGF PKNOX1 ARNT YBX1 ZBTB7B TCF12 GLIS2 ELK1 ZNF207 KLF7 DIDO1 RPS21 GMEB2 TAF4 MRGBP FNDC11 LAMA5 ENSG00000226332 LINC00659 GC20P062803
GH20H063845 1.6 Ensembl ENCODE dbSUPER 10.9 +299.4 299436 3.3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A YBX1 FEZF1 DMAP1 ZBTB7B DIDO1 MIR647 UCKL1 PCMTD2 TNFRSF6B RTEL1 ZNF512B PRPF6 ENSG00000237371 CICP4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FNDC11 on UCSC Golden Path with GeneCards custom track

Genomic Locations for FNDC11 Gene

Genomic Locations for FNDC11 Gene
chr20:63,547,891-63,556,708
(GRCh38/hg38)
Size:
8,818 bases
Orientation:
Plus strand
chr20:62,184,373-62,188,061
(GRCh37/hg19)

Genomic View for FNDC11 Gene

Genes around FNDC11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNDC11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNDC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC11 Gene

Proteins for FNDC11 Gene

  • Protein details for FNDC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVV2-FND11_HUMAN
    Recommended name:
    Fibronectin type III domain-containing protein 11
    Protein Accession:
    Q9BVV2

    Protein attributes for FNDC11 Gene

    Size:
    318 amino acids
    Molecular mass:
    36526 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FNDC11 Gene

Post-translational modifications for FNDC11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FNDC11 Gene

No data available for DME Specific Peptides for FNDC11 Gene

Domains & Families for FNDC11 Gene

Gene Families for FNDC11 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FNDC11 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FNDC11: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for FNDC11 Gene

Function for FNDC11 Gene

Phenotypes From GWAS Catalog for FNDC11 Gene

Gene Ontology (GO) - Molecular Function for FNDC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with FNDC11: view
genes like me logo Genes that share phenotypes with FNDC11: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FNDC11 Gene

Localization for FNDC11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FNDC11 gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Aggresome (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FNDC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FNDC11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FNDC11 Gene

Pathways & Interactions for FNDC11 Gene

SuperPathways for FNDC11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FNDC11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FNDC11 Gene

Drugs & Compounds for FNDC11 Gene

No Compound Related Data Available

Transcripts for FNDC11 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC11 Gene

No ASD Table

Relevant External Links for FNDC11 Gene

GeneLoc Exon Structure for
FNDC11
ECgene alternative splicing isoforms for
FNDC11

Expression for FNDC11 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FNDC11 Gene

Orthologs for FNDC11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FNDC11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C20orf195 34
  • 99 (a)
OneToOne
C20H20orf195 33
  • 98.64 (n)
dog
(Canis familiaris)
Mammalia C24H20orf195 33
  • 86.35 (n)
C20orf195 34
  • 58 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C13H20orf195 33
  • 86.14 (n)
C20orf195 34
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC051628 33 34
  • 83.07 (n)
Fndc11 16
rat
(Rattus norvegicus)
Mammalia RGD1564340 33
  • 82.33 (n)
chicken
(Gallus gallus)
Aves C20H20ORF195 33
  • 57.38 (n)
C20orf195 34
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C20orf195 34
  • 56 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2493 33
Species where no ortholog for FNDC11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FNDC11 Gene

ENSEMBL:
Gene Tree for FNDC11 (if available)
TreeFam:
Gene Tree for FNDC11 (if available)

Paralogs for FNDC11 Gene

No data available for Paralogs for FNDC11 Gene

Variants for FNDC11 Gene

Sequence variations from dbSNP and Humsavar for FNDC11 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000149258 -- 63,552,534(+) GCTCT(A/G)CCCCC upstream-variant-2KB
rs1001302991 -- 63,551,889(+) GACTA(C/T)AGGCG upstream-variant-2KB
rs1001338645 -- 63,551,566(+) AAGTA(A/G)AAGTT upstream-variant-2KB
rs1002185245 -- 63,553,757(+) CCAGG(A/C)GCTGG intron-variant, upstream-variant-2KB
rs1003199331 -- 63,554,885(+) GCTGC(A/G/T)GCAGA intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FNDC11 Gene

Variant ID Type Subtype PubMed ID
nsv9825 CNV gain 18304495
nsv953306 CNV deletion 24416366
nsv834034 CNV loss 17160897
nsv834033 CNV gain 17160897
nsv586573 CNV loss 21841781
nsv586571 CNV loss 21841781
nsv521734 CNV loss 19592680
nsv517702 CNV loss 19592680
nsv470563 CNV loss 18288195
esv2758806 CNV gain+loss 17122850
esv2722935 CNV deletion 23290073
dgv7668n54 CNV loss 21841781
dgv7667n54 CNV loss 21841781
dgv522n27 CNV loss 19166990
dgv521n27 CNV loss 19166990
dgv35n64 CNV loss 17921354

Variation tolerance for FNDC11 Gene

Residual Variation Intolerance Score: 15.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FNDC11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FNDC11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNDC11 Gene

Disorders for FNDC11 Gene

Relevant External Links for FNDC11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FNDC11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FNDC11

No disorders were found for FNDC11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FNDC11 Gene

Publications for FNDC11 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for FNDC11 Gene

Sources for FNDC11 Gene

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