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Aliases for FNDC10 Gene

Aliases for FNDC10 Gene

  • Fibronectin Type III Domain Containing 10 2 3 5
  • C1orf233 3 4
  • Fibronectin Type-III Domain-Containing Transmembrane Protein C1orf233 3
  • Fibronectin Type III Domain-Containing Protein 10 3
  • Chromosome 1 Open Reading Frame 233 2

External Ids for FNDC10 Gene

Previous HGNC Symbols for FNDC10 Gene

  • C1orf233

Previous GeneCards Identifiers for FNDC10 Gene

  • GC01M001631
  • GC01M001638

Summaries for FNDC10 Gene

GeneCards Summary for FNDC10 Gene

FNDC10 (Fibronectin Type III Domain Containing 10) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNDC10 Gene

Genomics for FNDC10 Gene

Regulatory Elements for FNDC10 Gene

Enhancers for FNDC10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G002203 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.4 -606.9 -606941 7.7 FOXA2 CREB3L1 MLX AGO1 ARID4B DMAP1 ZNF2 YY1 ZNF143 ZNF207 MORN1 FAAP20 SKI LOC100129534 LINC01786 RER1 ENSG00000240731 ENSG00000272455 PRKCZ-AS1 SLC35E2
GH01G002045 1.6 FANTOM5 ENCODE dbSUPER 5.6 -450.0 -449969 8.8 MLX ARID4B DMAP1 YY1 ZNF143 FOS ZNF263 SP3 SP5 NFYC PRKCZ ENSG00000271806 ANKRD65 FNDC10 SLC35E2B UBE2J2 NADK GC01P002049 LOC105378591
GH01G001596 0.9 ENCODE 0.7 +2.5 2471 1.5 HDGF CBX3 SIN3A RAD21 ZNF48 GLIS2 EGR1 ZNF366 SCRT2 ZHX2 SLC35E2B ANKRD65 FNDC10 GC01P001590
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FNDC10 on UCSC Golden Path with GeneCards custom track

Promoters for FNDC10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000000206 96 801 HDAC1 RB1 CREB3L1 FUS AGO1 SIN3A EGR2 REST ZNF398 HDAC8

Genomic Location for FNDC10 Gene

Chromosome:
1
Start:
1,598,008 bp from pter
End:
1,600,096 bp from pter
Size:
2,089 bases
Orientation:
Minus strand

Genomic View for FNDC10 Gene

Genes around FNDC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNDC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNDC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC10 Gene

Proteins for FNDC10 Gene

  • Protein details for FNDC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    F2Z333-FND10_HUMAN
    Recommended name:
    Fibronectin type III domain-containing protein 10
    Protein Accession:
    F2Z333

    Protein attributes for FNDC10 Gene

    Size:
    226 amino acids
    Molecular mass:
    24218 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FNDC10 Gene

Post-translational modifications for FNDC10 Gene

No Post-translational modifications

Other Protein References for FNDC10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FNDC10 Gene

Domains & Families for FNDC10 Gene

Protein Domains for FNDC10 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FNDC10: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for FNDC10 Gene

Function for FNDC10 Gene

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FNDC10 Gene

Localization for FNDC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNDC10 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FNDC10 gene
Compartment Confidence
plasma membrane 2
extracellular 2

Gene Ontology (GO) - Cellular Components for FNDC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FNDC10: view

Pathways & Interactions for FNDC10 Gene

SuperPathways for FNDC10 Gene

No Data Available

Interacting Proteins for FNDC10 Gene

Selected Interacting proteins: F2Z333-FND10_HUMAN for FNDC10 Gene via IID

Symbol External ID(s) Details
YWHAE

Gene Ontology (GO) - Biological Process for FNDC10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FNDC10 Gene

Transcripts for FNDC10 Gene

mRNA/cDNA for FNDC10 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC10 Gene

No ASD Table

Relevant External Links for FNDC10 Gene

GeneLoc Exon Structure for
FNDC10
ECgene alternative splicing isoforms for
FNDC10

Expression for FNDC10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of FNDC10 Gene:

FNDC10
genes like me logo Genes that share expression patterns with FNDC10: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FNDC10 Gene

Orthologs for FNDC10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FNDC10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf233 34
  • 97.79 (n)
C1orf233 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5H1orf233 34
  • 92 (n)
C1orf233 35
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C16H1orf233 34
  • 88.78 (n)
C1orf233 35
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC680656 34
  • 88.49 (n)
mouse
(Mus musculus)
Mammalia B930041F14Rik 35 34
  • 86.63 (n)
OneToOne
Fndc10 16
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733145 34
  • 60.85 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101885825 34
  • 60.75 (n)
Species where no ortholog for FNDC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FNDC10 Gene

ENSEMBL:
Gene Tree for FNDC10 (if available)
TreeFam:
Gene Tree for FNDC10 (if available)

Paralogs for FNDC10 Gene

No data available for Paralogs for FNDC10 Gene

Variants for FNDC10 Gene

Sequence variations from dbSNP and Humsavar for FNDC10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000869921 -- 1,597,932(+) CCCAA(C/G)GGTCC downstream-variant-500B
rs1000895193 -- 1,600,589(+) TACCT(A/G)CCCAT intron-variant, upstream-variant-2KB
rs1001276122 -- 1,599,364(+) GCGCG(C/G)GAGGG upstream-variant-2KB, reference, missense
rs1001357756 -- 1,601,939(+) GGTCA(C/T)GGGGA nc-transcript-variant, upstream-variant-2KB
rs1001384644 -- 1,598,176(+) AGTGA(C/G)CAGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FNDC10 Gene

Variant ID Type Subtype PubMed ID
dgv5n111 CNV deletion 26073780
dgv8n100 CNV loss 25217958
esv2758913 CNV gain+loss 17122850
esv2760410 CNV gain+loss 21179565
nsv10161 CNV gain+loss 18304495
nsv1073621 CNV deletion 25765185
nsv1136056 CNV deletion 24896259
nsv1160797 CNV duplication 26073780
nsv482937 CNV loss 15286789
nsv950452 CNV deletion 24416366

Variation tolerance for FNDC10 Gene

Gene Damage Index Score: 0.36; 7.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FNDC10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FNDC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNDC10 Gene

Disorders for FNDC10 Gene

Relevant External Links for FNDC10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FNDC10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FNDC10

No disorders were found for FNDC10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FNDC10 Gene

Publications for FNDC10 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3 64

Products for FNDC10 Gene

Sources for FNDC10 Gene

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