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Aliases for FNDC1 Gene

Aliases for FNDC1 Gene

  • Fibronectin Type III Domain Containing 1 2 3 5
  • Fibronectin Type III Domain Containing 2 2 3
  • Expressed In Synovial Lining Protein 3 4
  • Activation-Associated CDNA Protein 3 4
  • MEL4B3 3 4
  • FNDC2 3 4
  • Fibronectin Type III Domain-Containing Protein 1 3
  • BA243O10.1 3
  • DJ322A24.1 3
  • EC 6.1.1.1 61
  • EC 2.7.2.3 61
  • KIAA1866 4
  • AGS8 3

External Ids for FNDC1 Gene

Previous HGNC Symbols for FNDC1 Gene

  • FNDC2

Previous GeneCards Identifiers for FNDC1 Gene

  • GC06P159484
  • GC06P159560
  • GC06P159609
  • GC06P159510
  • GC06P159590
  • GC06P157060

Summaries for FNDC1 Gene

GeneCards Summary for FNDC1 Gene

FNDC1 (Fibronectin Type III Domain Containing 1) is a Protein Coding gene. Diseases associated with FNDC1 include Prostate Leiomyosarcoma. An important paralog of this gene is ABI3BP.

UniProtKB/Swiss-Prot for FNDC1 Gene

  • May be an activator of G protein signaling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNDC1 Gene

Genomics for FNDC1 Gene

Regulatory Elements for FNDC1 Gene

Enhancers for FNDC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F159202 1 Ensembl ENCODE 35.9 +34.4 34357 1.5 BHLHE40 FNDC1 LOC101929122 FNDC1-IT1
GH06F159248 0.4 ENCODE 13.5 +80.3 80318 1.7 FNDC1 FNDC1-IT1 ENSG00000231178
GH06F159463 0.2 ENCODE 12.9 +295.3 295333 1.7 ZMYM3 LOC101929122 FNDC1 GC06P159466 LOC101929142
GH06F159282 0.2 ENCODE 11.8 +113.1 113076 0.8 FNDC1 FNDC1-IT1 ENSG00000231178
GH06F159456 0.4 ENCODE 11.4 +287.1 287137 1.1 ZNF263 SCRT2 ZMYM3 NFXL1 ATF2 FNDC1 LOC101929142 PIR47548
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FNDC1 on UCSC Golden Path with GeneCards custom track

Promoters for FNDC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001710068 103 1401 ZFP64 INSM2 ZNF2 RAD21 ZEB1 GLIS2 ZNF391 EGR2 ZNF263 ZNF202

Genomic Location for FNDC1 Gene

Chromosome:
6
Start:
159,169,397 bp from pter
End:
159,272,109 bp from pter
Size:
102,713 bases
Orientation:
Plus strand

Genomic View for FNDC1 Gene

Genes around FNDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC1 Gene

Proteins for FNDC1 Gene

  • Protein details for FNDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4ZHG4-FNDC1_HUMAN
    Recommended name:
    Fibronectin type III domain-containing protein 1
    Protein Accession:
    Q4ZHG4
    Secondary Accessions:
    • A6H8X2
    • B7ZBR4
    • B7ZBR5
    • B9EK49
    • Q5JPI0
    • Q5VU31
    • Q5VU32
    • Q5VXX4
    • Q70CQ6
    • Q96JG1

    Protein attributes for FNDC1 Gene

    Size:
    1894 amino acids
    Molecular mass:
    205558 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI46784.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI50608.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAY26234.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAE51894.1; Type=Frameshift; Positions=1487; Evidence={ECO:0000305}; Sequence=CAX14958.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FNDC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FNDC1 Gene

Selected DME Specific Peptides for FNDC1 Gene

Post-translational modifications for FNDC1 Gene

  • Glycosylation at Asn 149, Ser 713, Ser 717, Ser 737, Ser 759, Ser 761, Ser 847, and Asn 1661
  • Modification sites at PhosphoSitePlus

Other Protein References for FNDC1 Gene

Domains & Families for FNDC1 Gene

Gene Families for FNDC1 Gene

Protein Domains for FNDC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FNDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4ZHG4

UniProtKB/Swiss-Prot:

FNDC1_HUMAN :
  • Contains 5 fibronectin type-III domains.
Domain:
  • Contains 5 fibronectin type-III domains.
genes like me logo Genes that share domains with FNDC1: view

Function for FNDC1 Gene

Molecular function for FNDC1 Gene

UniProtKB/Swiss-Prot Function:
May be an activator of G protein signaling.
UniProtKB/Swiss-Prot Induction:
By TGFB1 present in the melanoma cell conditioned medium (MCCM).

Enzyme Numbers (IUBMB) for FNDC1 Gene

genes like me logo Genes that share phenotypes with FNDC1: view

Animal Model Products

miRNA for FNDC1 Gene

miRTarBase miRNAs that target FNDC1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FNDC1 Gene

Localization for FNDC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNDC1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FNDC1 Gene COMPARTMENTS Subcellular localization image for FNDC1 gene
Compartment Confidence
nucleus 5
extracellular 4
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FNDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with FNDC1: view

Pathways & Interactions for FNDC1 Gene

SuperPathways for FNDC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FNDC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FNDC1 Gene

Transcripts for FNDC1 Gene

Unigene Clusters for FNDC1 Gene

Fibronectin type III domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC1 Gene

No ASD Table

Relevant External Links for FNDC1 Gene

GeneLoc Exon Structure for
FNDC1
ECgene alternative splicing isoforms for
FNDC1

Expression for FNDC1 Gene

mRNA expression in normal human tissues for FNDC1 Gene

mRNA differential expression in normal tissues according to GTEx for FNDC1 Gene

This gene is overexpressed in Thyroid (x9.6) and Colon - Sigmoid (x5.5).

Protein differential expression in normal tissues from HIPED for FNDC1 Gene

This gene is overexpressed in Amniocyte (14.8), Bone marrow mesenchymal stem cell (14.3), Breast (8.8), Fetal gut (7.7), Esophagus (7.3), and Fetal ovary (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FNDC1 Gene



NURSA nuclear receptor signaling pathways regulating expression of FNDC1 Gene:

FNDC1

SOURCE GeneReport for Unigene cluster for FNDC1 Gene:

Hs.520525

mRNA Expression by UniProt/SwissProt for FNDC1 Gene:

Q4ZHG4-FNDC1_HUMAN
Tissue specificity: Almost absent from healthy skin; especially in epidermal keratinocytes, skin fibroblasts or endothelial cells and is barely detectable in benign melanocytic naevi. Expressed in the stroma close to skin tumors, in the tumor cells themselves and in the epidermis of psoriasis.
genes like me logo Genes that share expression patterns with FNDC1: view

Primer Products

No data available for Protein tissue co-expression partners for FNDC1 Gene

Orthologs for FNDC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FNDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FNDC1 34 35
  • 99.06 (n)
dog
(Canis familiaris)
Mammalia FNDC1 34 35
  • 80.57 (n)
rat
(Rattus norvegicus)
Mammalia Fndc1 34
  • 76.51 (n)
cow
(Bos Taurus)
Mammalia FNDC1 35
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fndc1 35
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FNDC1 35
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FNDC1 35
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves FNDC1 35
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 92 (a)
OneToMany
-- 35
  • 37 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fndc1 35
  • 35 (a)
OneToOne
Species where no ortholog for FNDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FNDC1 Gene

ENSEMBL:
Gene Tree for FNDC1 (if available)
TreeFam:
Gene Tree for FNDC1 (if available)

Paralogs for FNDC1 Gene

Paralogs for FNDC1 Gene

genes like me logo Genes that share paralogs with FNDC1: view

Variants for FNDC1 Gene

Sequence variations from dbSNP and Humsavar for FNDC1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10214809 -- 159,187,438(+) AAGAG(A/C)TAGGG intron-variant
rs10214810 -- 159,187,506(+) CACTT(C/T)TATTG intron-variant
rs10455856 -- 159,223,017(+) tgagg(G/T)ggagt intron-variant
rs10537794 -- 159,227,647(+) TTCTC(-/T)TTTTT intron-variant
rs10564196 -- 159,173,283(+) TCCGC(-/GC)TTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FNDC1 Gene

Variant ID Type Subtype PubMed ID
dgv3424n106 CNV deletion 24896259
dgv3425n106 CNV deletion 24896259
esv1197817 CNV deletion 17803354
esv1401887 CNV deletion 17803354
esv22549 CNV loss 19812545
esv2287378 CNV deletion 18987734
esv2307373 CNV deletion 18987734
esv2473194 CNV deletion 19546169
esv2595923 CNV deletion 19546169
esv2665874 CNV deletion 23128226
esv2733023 CNV deletion 23290073
esv2733024 CNV deletion 23290073
esv2733025 CNV deletion 23290073
esv2763604 CNV gain 21179565
esv3282607 CNV deletion 24192839
esv3540757 CNV deletion 23714750
esv3540758 CNV deletion 23714750
esv3611412 CNV loss 21293372
esv3611413 CNV loss 21293372
esv4520 CNV loss 18987735
esv992188 CNV deletion 20482838
esv995554 CNV deletion 20482838
nsv1019191 CNV gain 25217958
nsv1073603 CNV deletion 25765185
nsv1073604 CNV deletion 25765185
nsv1073605 CNV deletion 25765185
nsv1074440 CNV deletion 25765185
nsv1119090 CNV deletion 24896259
nsv1148320 CNV deletion 26484159
nsv1153310 CNV deletion 26484159
nsv349266 CNV deletion 16902084
nsv474187 CNV novel sequence insertion 20440878
nsv830850 CNV gain 17160897
nsv830851 CNV gain 17160897
nsv949877 CNV deletion 24416366
nsv956939 CNV deletion 24416366
nsv956943 CNV deletion 24416366

Variation tolerance for FNDC1 Gene

Residual Variation Intolerance Score: 98.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.94; 97.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FNDC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FNDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNDC1 Gene

Disorders for FNDC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FNDC1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
prostate leiomyosarcoma
  • leiomyosarcoma of the prostate
- elite association - COSMIC cancer census association via MalaCards
Search FNDC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FNDC1

Genetic Association Database (GAD)
FNDC1
Human Genome Epidemiology (HuGE) Navigator
FNDC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FNDC1
genes like me logo Genes that share disorders with FNDC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FNDC1 Gene

Publications for FNDC1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease. (PMID: 21606135) Wild P.S. … Blankenberg S. (Circ Cardiovasc Genet 2011) 3 46 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. MEL4B3, a novel mRNA is induced in skin tumors and regulated by TGF- beta and pro-inflammatory cytokines. (PMID: 16098131) Anderegg U. … Saalbach A. (Exp. Dermatol. 2005) 3 4 64
  5. Use of differential subtraction method to identify genes that characterize the phenotype of cultured rheumatoid arthritis synoviocytes. (PMID: 9704633) Seki T. … Winchester R. (Arthritis Rheum. 1998) 3 4 64

Products for FNDC1 Gene

Sources for FNDC1 Gene

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