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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FNDC1 Gene

protein-coding   GIFtS: 47
GCID: GC06P159590

Fibronectin Type III Domain Containing 1

(Previous name: fibronectin type III domain containing 2)
(Previous symbol: FNDC2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fibronectin Type III Domain Containing 11 2     KIAA18663 5
FNDC21 2 3     RP11-243O10.22
Fibronectin Type III Domain Containing 21 2     bA243O10.12
Activation-Associated CDNA Protein2 3     dJ322A24.12
Expressed In Synovial Lining Protein2 3     Fibronectin Type III Domain-Containing Protein 12
MEL4B32 3     EC 2.7.2.38
AGS82 5     EC 6.1.1.18

External Ids:    HGNC: 211841   Entrez Gene: 846242   Ensembl: ENSG000001646947   OMIM: 6099915   UniProtKB: Q4ZHG43   

Export aliases for FNDC1 gene to outside databases

Previous GC identifers: GC06P159484 GC06P159560 GC06P159609 GC06P159510 GC06P157060


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FNDC1 Gene: 
FNDC1 (fibronectin type III domain containing 1) is a protein-coding gene. Diseases associated with FNDC1 include prostate leiomyosarcoma, and leiomyosarcoma. An important paralog of this gene is ABI3BP.

UniProtKB/Swiss-Prot: FNDC1_HUMAN, Q4ZHG4
Function: May be an activator of G protein signaling (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FNDC1 gene promoter:
         ISGF-3   E4BP4   AREB6   IRF-2   POU2F1   GATA-6   POU2F1a   POU2F1b   POU2F1c   Ik-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FNDC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FNDC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q25

FNDC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FNDC1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P159590:  view genomic region     (about GC identifiers)

Start:
159,590,429 bp from pter      End:
159,693,141 bp from pter
Size:
102,713 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FNDC1_HUMAN, Q4ZHG4 (See protein sequence)
Recommended Name: Fibronectin type III domain-containing protein 1 precursor  
Size: 1894 amino acids; 205558 Da
Subcellular location: Secreted (Potential)
Caution: It is uncertain whether Met-1 or Met-53 is the initiator
Sequence caution: Sequence=AAI46784.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI50608.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAY26234.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAE51894.1; Type=Frameshift;
Positions=1487; Sequence=CAX14958.1; Type=Erroneous gene model prediction;
Secondary accessions: A6H8X2 B7ZBR4 B7ZBR5 B9EK49 Q5JPI0 Q5VU31 Q5VU32 Q5VXX4 Q70CQ6 Q96JG1
Alternative splicing: 2 isoforms:  Q4ZHG4-1   Q4ZHG4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FNDC1: NX_Q4ZHG4

Explore proteomics data for FNDC1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q4ZHG4

  • 2 DME Specific Peptides for FNDC1 (Q4ZHG4)
     EGKVLPG  PLRIKLG 

    FNDC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FNDC1 Protein Expression
    REFSEQ proteins: NP_115921.2  
    ENSEMBL proteins: 
     ENSP00000297267   ENSP00000333297   ENSP00000342460  

    Human Recombinant Protein Products for FNDC1: 
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    Cloud-Clone Corp. Proteins for FNDC1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane IEA--
    GO:0005911cell-cell junction IEA--
    GO:0031966mitochondrial membrane IEA--

    FNDC1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FN3: Fibronectin type III domain containing

    2 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q4ZHG4

    ProtoNet protein and cluster: Q4ZHG4

    UniProtKB/Swiss-Prot: FNDC1_HUMAN, Q4ZHG4
    Similarity: Contains 5 fibronectin type-III domains


    FNDC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FNDC1_HUMAN, Q4ZHG4
    Function: May be an activator of G protein signaling (By similarity)
    Induction: By TGFB1 present in the melanoma cell conditioned medium (MCCM)

         Enzyme Numbers (IUBMB): EC 6.1.1.12 EC 2.7.2.32

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    FNDC1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FNDC1:
     Increased S DNA content 

    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FNDC1

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation IEA--
    GO:0010666positive regulation of cardiac muscle cell apoptotic process IEA--
    GO:0051223regulation of protein transport IEA--
    GO:0071456cellular response to hypoxia IEA--

    FNDC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FNDC1

    Search CenterWatch for drugs/clinical trials and news about FNDC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FNDC1 gene: 
    NM_032532.2  

    Unigene Cluster for FNDC1:

    Fibronectin type III domain containing 1
    Hs.520525  [show with all ESTs]
    Unigene Representative Sequence: NM_032532
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297267(uc010kjv.3) ENST00000329629 ENST00000480856 ENST00000340366(uc010kjw.1)

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate FNDC1:
    hsa-miR-3166 hsa-miR-580 hsa-miR-1179
    SwitchGear 3'UTR luciferase reporter plasmidFNDC1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB058769.2 AJ586132.1 AK127635.1 AL832410.1 BC146783.1 BC150607.1 DQ009660.1 

    3 DOTS entries:

    DT.100743555  DT.312319  DT.97808643 

    24/47 AceView cDNA sequences (see all 47):

    CA414836 AI913309 AA722681 AI394583 AI432959 H88455 AI738683 BQ005219 
    BQ002201 CD676759 AI868819 AW317022 AA377805 AI677991 BU616211 AI627661 
    AW292066 BQ009013 AJ586132 BF002061 CA421344 CA414744 CA414982 AI370662 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FNDC1 expression in normal human tissues (normalized intensities)      FNDC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTCTGTTT
    FNDC1 Expression
    About this image


    FNDC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 8 entries
             Chondrocytes Zeugopod Epiphyseal End
             HyStem+TGFbeta3+GDF5-induced SK11 cells
             Normal Human osteoblasts (NHOST)   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 7 entries
             Chondrocytes Zeugopod Epiphyseal End
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Endothelial Cells Blood Brain Barrier
             Human Astrocytes   
     
     Mesenchymal Stem Cells (Muscoskeletal System)    fully expand to see all 3 entries
             Human Mesenchymal Stem Cells (hMSC)-1   
     
     Blood Brain Barrier (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier

    See FNDC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FNDC1

    SOURCE GeneReport for Unigene cluster: Hs.520525

    UniProtKB/Swiss-Prot: FNDC1_HUMAN, Q4ZHG4
    Tissue specificity: Almost absent from healthy skin; especially in epidermal keratinocytes, skin fibroblasts or
    endothelial cells and is barely detectable in benign melanocytic naevi. Expressed in the stroma close to skin
    tumors, in the tumor cells themselves and in the epidermis of psoriasis

        SABiosciences Custom PCR Arrays for FNDC1
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FNDC1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fndc11 , 5 fibronectin type III domain containing 11, 5 76.34(n)1
    72.56(a)1
      17 (4.77 cM)5
    686551  NM_001081416.11  NP_001074885.11 
     77385695 
    chicken
    (Gallus gallus)
    Aves FNDC11 fibronectin type III domain containing 1 57.54(n)
    54.04(a)
      421589  XM_419627.3  XP_419627.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    92(a)
    36(a)
    1 ↔ many
    1 ↔ many
    1(212404537-212418601)
    1(212446695-212480399)
    zebrafish
    (Danio rerio)
    Actinopterygii fndc16
    fibronectin type III domain containing 1
    35(a)
    1 ↔ 1
    20(31028096-31093168)


    ENSEMBL Gene Tree for FNDC1 (if available)
    TreeFam Gene Tree for FNDC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FNDC1 gene
    ABI3BP2  

    FNDC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2498 SNPs in FNDC1 are shown (see all 2498)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs69107521,2
    C--159588525(+) AGCCTC/TTGGTG 1 -- us2k10--------
    rs1142236841,2
    F--159588644(+) TTACAT/CACATG 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs2953361,2
    C,H--159588747(+) CAGGGC/TCAGGG 1 -- us2k112Minor allele frequency- T:0.14NA WA CSA EA 374
    rs1877275651,2
    --159588981(+) GGTTGC/GAGTTG 1 -- us2k10--------
    rs1392325881,2
    --159588984(+) TGGAGC/TTGGGG 1 -- us2k10--------
    rs1923917431,2
    --159589043(+) GAGACA/CGAAAC 1 -- us2k10--------
    rs2953351,2
    C,F,A,H--159589126(+) GCTGGA/GCGTGG 1 -- us2k122Minor allele frequency- G:0.48NS EA NA WA CSA 2348
    rs1118422591,2
    F--159589271(+) GTGGCT/CGAAAC 1 -- us2k12Minor allele frequency- C:0.06CSA WA 120
    rs735912201,2
    C,F--159589283(+) TGTAGC/TCCCAG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1449153281,2
    C--159589418(+) AAAAAC/GAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FNDC1 (159590429 - 159693141 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/18 variations for FNDC1 (see all 18):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1197817CNV Deletion17803354
    esv2733025CNV Deletion23290073
    esv2665874CNV Deletion23128226
    esv2473194CNV Deletion19546169
    esv2733024CNV Deletion23290073
    esv2307373CNV Deletion18987734
    esv992188CNV Deletion20482838
    esv2287378CNV Deletion18987734
    esv1401887CNV Deletion17803354
    esv2733023CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609991    OMIM disorders: --

    9 diseases for FNDC1:    About MalaCards
    prostate leiomyosarcoma    leiomyosarcoma    psoriasis    hypoxia
    rheumatoid arthritis    arthritis    melanoma    prostatitis
    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for FNDC1:
    Prostate leiomyosarcoma

    FNDC1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FNDC1
    Human Genome Epidemiology (HuGE) Navigator: FNDC1 (1 document)

    Export disorders for FNDC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FNDC1 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with FNDC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2, 3 Nagase T.... Ohara O. (2001)
    2. A Genome-Wide Association Study Identifies LIPA as a Susceptibility Gene for Coronary Artery Disease. (PubMed id 21606135)1, 4 Wild P.S....Blankenberg S. (2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. MEL4B3, a novel mRNA is induced in skin tumors and regulated by TGF- beta and pro-inflammatory cytokines. (PubMed id 16098131)1, 2 Anderegg U.... Saalbach A. (2005)
    5. Use of differential subtraction method to identify genes that characterize the phenotype of cultured rheumatoid arthritis synoviocytes. (PubMed id 9704633)1, 2 Seki T.... Winchester R. (1998)
    6. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (2007)
    7. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (2007)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84624 HGNC: 21184 AceView: FNDC1 Ensembl:ENSG00000164694 euGenes: HUgn84624
    ECgene: FNDC1 H-InvDB: FNDC1

    (According to HUGE)
    About This Section
    HUGE: KIAA1866

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FNDC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FNDC1 gene:
    Search GeneIP for patents involving FNDC1

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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