Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FNDC1 Gene

protein-coding GIFtS: 47
GCID: GC06P159590

fibronectin type III domain containing 1

(Previous name: fibronectin type III domain containing 2 )
(Previous symbol: FNDC2)

Explore 8 diseases affiliated with
FNDC1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Fibronectin Type III Domain Containing 1¹ ²		Expressed In Synovial Lining Protein² ³
FNDC2¹ ² ³		MEL4B3² ³
KIAA1866¹ ³ ⁵		AGS8² ⁵
BA243O10.1¹		RP11-243O10.2²
DJ322A24.1¹		Fibronectin Type III Domain-Containing Protein 1²
Fibronectin Type III Domain Containing 2¹ ²		EC 2.7.2.3⁸
Activation-Associated CDNA Protein² ³		EC 6.1.1.1⁸

External Ids:	HGNC: 21184¹	Entrez Gene: 84624²	Ensembl: ENSG00000164694⁷	OMIM: 609991⁵	UniProtKB: Q4ZHG4³

Export aliases for FNDC1 gene to outside databases

Previous GC identifers: GC06P159484 GC06P159560 GC06P159609 GC06P159510 GC06P157060

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: FNDC1_HUMAN, Q4ZHG4

Function: May be an activator of G protein signaling (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FNDC1 gene promoter:
ISGF-3 E4BP4 AREB6 IRF-2 POU2F1 GATA-6 POU2F1a POU2F1b POU2F1c Ik-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for FNDC1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FNDC1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25 Ensembl cytogenetic band: 6q25.3 HGNC cytogenetic band: 6q25

FNDC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FNDC1 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P159590: view genomic region (about GC identifiers)

Start:	159,590,429 bp from pter	End:	159,693,141 bp from pter
Size:	102,713 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FNDC1_HUMAN, Q4ZHG4 (See protein sequence)

Recommended Name: Fibronectin type III domain-containing protein 1 precursor

Size: 1894 amino acids; 205558 Da

Subcellular location: Secreted (Potential)

Caution: It is uncertain whether Met-1 or Met-53 is the initiator

Sequence caution: Sequence=AAI46784.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=AAI50608.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAY26234.1;

Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAE51894.1; Type=Frameshift;

Positions=1487; Sequence=CAX14958.1; Type=Erroneous gene model prediction;

Secondary accessions: A6H8X2 B7ZBR4 B7ZBR5 B9EK49 Q5JPI0 Q5VU31 Q5VU32 Q5VXX4 Q70CQ6 Q96JG1

Alternative splicing: 2 isoforms: Q4ZHG4-1 Q4ZHG4-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FNDC1: NX_Q4ZHG4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q4ZHG4

2 DME Specific Peptides for FNDC1 (Q4ZHG4)

EGKVLPG

PLRIKLG

FNDC1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_115921.2

ENSEMBL proteins:

ENSP00000297267 ENSP00000333297 ENSP00000342460

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for FNDC1
	GenScript Custom Purified and Recombinant Proteins Services for FNDC1
	Novus Biologicals FNDC1 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FNDC1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005737	cytoplasm	--	--
GO:0005886	plasma membrane	IEA	--
GO:0005911	cell-cell junction	IEA	--
GO:0031966	mitochondrial membrane	IEA	--

FNDC1 for ontologies About GeneDecksing

FNDC1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for FNDC1
	GenScript Custom Superior Antibodies Services for FNDC1
	Novus Biologicals FNDC1 Antibody
	Search for Antibodies for FNDC1 at Abcam
	Uscn Antibodies for FNDC1
	Search ThermoFisher Antibodies for FNDC1

Assay Products for FNDC1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FNDC1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FNDC1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FNDC1 for domains About GeneDecksing

2 InterPro domains/families:

IPR003961 Fibronectin_type3

IPR013783 Ig-like_fold

Graphical View of Domain Structure for InterPro Entry Q4ZHG4

ProtoNet protein and cluster: Q4ZHG4

UniProtKB/Swiss-Prot: FNDC1_HUMAN, Q4ZHG4

Similarity: Contains 5 fibronectin type-III domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FNDC1_HUMAN, Q4ZHG4

Function: May be an activator of G protein signaling (By similarity)

Induction: By TGFB1 present in the melanoma cell conditioned medium (MCCM)

Enzyme Numbers (IUBMB): EC 6.1.1.1² EC 2.7.2.3²

miRNA Products:		OriGene 3'-UTR Clone: FNDC1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FNDC1
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate FNDC1:
		hsa-miR-3166 hsa-miR-580 hsa-miR-1179
		SwitchGear 3'UTR luciferase reporter plasmid: FNDC1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FNDC1 (see all 7) OriGene shRNA RFP: FNDC1 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FNDC1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for FNDC1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FNDC1 (NM_032532)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FNDC1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNDC1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FNDC1
		Search LifeMap BioReagents cell lines for FNDC1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNDC1

1 GenomeRNAi human phenotype for FNDC1:

Increased S DNA content

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FNDC1

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001934	positive regulation of protein phosphorylation	IEA	--
GO:0010666	positive regulation of cardiac muscle cell apoptotic process	IEA	--
GO:0051223	regulation of protein transport	IEA	--
GO:0071456	cellular response to hypoxia	IEA	--

FNDC1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FNDC1
Search CenterWatch for drugs/clinical trials and news about FNDC1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FNDC1 gene:

NM_032532.2

Unigene Cluster for FNDC1:

Fibronectin type III domain containing 1

Hs.520525 [show with all ESTs]

Unigene Representative Sequence: NM_032532

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000297267(uc010kjv.3) ENST00000329629 ENST00000480856 ENST00000340366(uc010kjw.1)

miRNA Products:		OriGene 3'-UTR Clone: FNDC1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FNDC1
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate FNDC1:
		hsa-miR-3166 hsa-miR-580 hsa-miR-1179
		SwitchGear 3'UTR luciferase reporter plasmid: FNDC1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FNDC1 (see all 7) OriGene shRNA RFP: FNDC1 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FNDC1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FNDC1 (NM_032532)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FNDC1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNDC1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FNDC1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat FNDC1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FNDC1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FNDC1

Additional cDNA sequence:

AB058769.2 AJ586132.1 AK127635.1 AL832410.1 BC146783.1 BC150607.1 DQ009660.1

3 DOTS entries:

DT.100743555 DT.312319 DT.97808643

24/47 AceView cDNA sequences (see all 47):

AI738683 H88455 AI394583 AI913309 CA414836 AA722681 AI432959 BQ005219

AW317022 CA414982 AL832410 BQ009013 CA414744 CA414764 BQ008677 AA377805

AI370662 AW207729 BU616211 AW292066 AI868819 CD676759 AI677991 BM992427

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FNDC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTCTGTTT

About this image

FNDC1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Zeugopod Epiphyseal End

Chondrocytes

Bone, Cartilage

Brain

Blood Brain Barrier

Postnatal Endothelial Cells

Blood Brain Barrier, Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

HyStem+TGF?3+GDF5-induced MEL2 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

TGF?3+BMP7-induced chondrocytes (Chondrogenic HyStem+...)

Bone, Cartilage

HyStem+TGF?3+GDF5-induced 4D20.8 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

HyStem+TGF?3+GDF5-induced E15 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

See FNDC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FNDC1

SOURCE GeneReport for Unigene cluster: Hs.520525

UniProtKB/Swiss-Prot: FNDC1_HUMAN, Q4ZHG4

Tissue specificity: Almost absent from healthy skin; especially in epidermal keratinocytes, skin fibroblasts or

endothelial cells and is barely detectable in benign melanocytic naevi. Expressed in the stroma close to skin tumors,

in the tumor cells themselves and in the epidermis of psoriasis

SABiosciences Custom PCR Arrays for FNDC1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FNDC1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat FNDC1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FNDC1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FNDC1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNDC1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FNDC1 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FNDC1¹	fibronectin type III domain containing 1	57.54(n) 54.04(a)		421589 XM_419627.3 XP_419627.3
lizard (Anolis carolinensis)	Reptilia	-- --	--	92(a) 40(a)	1 ↔ many 1 ↔ many	1(212404540-212415041) 1(212446695-212480399)
zebrafish (Danio rerio)	Actinopterygii	fndc1⁶	fibronectin type III domain containing 1	37(a)	1 ↔ 1	20(31028096-31093168)

ENSEMBL Gene Tree for FNDC1 (if available)
TreeFam Gene Tree for FNDC1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FNDC1 gene

ABI3BP²

FNDC1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6910752^1,2	C,	--	159588525(+)	`AGCCTC/TTGGTG`	1	--	us2k¹		0	--	--	--	--
rs114223684^1,2		--	159588644(+)	`TTACAT/CACATG`	1	--	us2k¹		1		WA	118
rs295336^1,2	C,H,	--	159588747(+)	`CAGGGC/TCAGGG`	1	--	us2k¹		12		NA WA CSA EA	374
rs187727565^1,2		--	159588981(+)	`GGTTGC/GAGTTG`	1	--	us2k¹		0	--	--	--	--
rs139232588^1,2		--	159588984(+)	`TGGAGC/TTGGGG`	1	--	us2k¹		0	--	--	--	--
rs192391743^1,2		--	159589043(+)	`GAGACA/CGAAAC`	1	--	us2k¹		0	--	--	--	--
rs295335^1,2	C,F,A,H,	--	159589126(+)	`GCTGGA/GCGTGG`	1	--	us2k¹		22		NS EA NA WA CSA	2348
rs111842259^1,2		--	159589271(+)	`GTGGCT/CGAAAC`	1	--	us2k¹		2		CSA WA	120
rs73591220^1,2	C,	--	159589283(+)	`TGTAGC/TCCCAG`	1	--	us2k¹		1		WA	2
rs144915328^1,2		--	159589418(+)	`AAAAAC/GAAAAA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FNDC1 (159590429 - 159693141 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for FNDC1
1 CNV: 4513
12 Indels: 47036 28136 40942 69632 42526 40940 99775 47035 40939 28137 12876 40941

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FNDC1

DNA2.0 Custom Variant and Variant Library Synthesis for FNDC1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FNDC1 for disorders           About GeneDecksing

OMIM gene information: 609991    OMIM disorders: --

8 diseases for FNDC1:    About MalaCards

leiomyosarcoma prostate leiomyosarcoma rheumatoid arthritis arthritis

psoriasis hypoxia prostatitis melanoma

1 disease from the University of Copenhagen DISEASES database for FNDC1:

Prostate leiomyosarcoma

Human Genome Epidemiology (HuGE) Navigator: FNDC1 (1 document)

Export disorders for FNDC1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FNDC1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FNDC1)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)^{1, 2, 3} Nagase T.... Ohara O. (2001)
MEL4B3, a novel mRNA is induced in skin tumors and regulated by TGF- beta and pro-inflammatory cytokines. (PubMed id 16098131)^{1, 2} Anderegg U.... Saalbach A. (2005)
Use of differential subtraction method to identify genes that characterize the phenotype of cultured rheumatoid arthritis synoviocytes. (PubMed id 9704633)^{1, 2} Seki T.... Winchester R. (1998)
A Genome-Wide Association Study Identifies LIPA as a Susceptibility Gene for Coronary Artery Disease. (PubMed id 21606135)¹ Wild P.S....Blankenberg S. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)² Mungall A.J.... Beck S. (2003)
Structure and functional significance of mechanically unfolded fibronectin type III1 intermediates. (PubMed id 14657397)¹ Gao M.... Schulten K. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84624	HGNC: 21184	AceView: FNDC1	Ensembl:ENSG00000164694	euGenes: HUgn84624
ECgene: FNDC1	H-InvDB: FNDC1

(According to HUGE)
About This Section

HUGE: KIAA1866

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FNDC1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FNDC1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FNDC1 gene:
Search GeneIP for patents involving FNDC1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for FNDC1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FNDC1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FNDC1
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	Browse OriGene siRNAs		OriGene 3'-UTR Clone for FNDC1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNDC1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for FNDC1		OriGene Custom Protein Services for FNDC1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FNDC1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FNDC1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FNDC1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FNDC1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FNDC1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FNDC1

	GenScript Custom Purified and Recombinant Proteins Services for FNDC1		GenScript cDNA clones with any tag delivered in your preferred vector for FNDC1
	GenScript Custom Assay Services for FNDC1		GenScript Custom Superior Antibodies Services for FNDC1
	GenScript Custom overexpressing Cell Line Services for FNDC1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in FNDC1 promoter
	Search Chromatin IP Primers for FNDC1
	RT² qPCR Primer Assay in human, mouse / rat FNDC1
	Search GNC Networks for FNDC1
	SABiosciences Custom PCR Arrays for FNDC1

Search Tocris compounds for FNDC1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	FNDC1 antibodies
	FNDC1 proteins

	Search for Antibodies for FNDC1 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for FNDC1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

FNDC1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for FNDC1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNDC1

	SwitchGear 3'UTR luciferase reporter plasmids for FNDC1
	Browse SwitchGear Promoter luciferase reporter plasmids for FNDC1

Search ThermoFisher Antibodies for FNDC1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FNDC1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes FNDC1 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

FNDC1 Gene

fibronectin type III domain containing 1

Aliases
for FNDC1 gene

Summaries
for FNDC1 gene

Genomic Views
for FNDC1 gene

Proteins
for FNDC1 gene

Protein Domains /
Families
for FNDC1 gene

Function
for FNDC1 gene

Pathways & Interactions
for FNDC1 gene

Drugs & Compounds
for FNDC1 gene

Transcripts
for FNDC1 gene

Expression
for FNDC1 gene

Orthologs
for FNDC1 gene

Paralogs
for FNDC1 gene

Genomic Variants
for FNDC1 gene

Disorders / Diseases
for FNDC1 gene

Publications
for FNDC1 gene

External Searches for FNDC1 gene

Genome Databases showing FNDC1 gene

Other Databases showing FNDC1 gene

Specialized Databases showing FNDC1 gene

Intellectual Property
for FNDC1 gene

Products
for FNDC1 gene

View Random Gene

Advanced Search

Export list of displayed genes

FNDC1 Gene

fibronectin type III domain containing 1

Aliasesfor FNDC1 gene

Summariesfor FNDC1 gene

Genomic Viewsfor FNDC1 gene

Proteinsfor FNDC1 gene

Protein Domains /Familiesfor FNDC1 gene

Functionfor FNDC1 gene

Pathways & Interactionsfor FNDC1 gene

Drugs & Compoundsfor FNDC1 gene

Transcriptsfor FNDC1 gene

Expression for FNDC1 gene

Orthologsfor FNDC1 gene

Paralogsfor FNDC1 gene

Genomic Variantsfor FNDC1 gene

Disorders / Diseasesfor FNDC1 gene

Publicationsfor FNDC1 gene

External Searches for FNDC1 gene

Genome Databases showing FNDC1 gene

Other Databases showing FNDC1 gene

Specialized Databases showing FNDC1 gene

Intellectual Propertyfor FNDC1 gene

Productsfor FNDC1 gene

View Random Gene

Aliases
for FNDC1 gene

Summaries
for FNDC1 gene

Genomic Views
for FNDC1 gene

Proteins
for FNDC1 gene

Protein Domains /
Families
for FNDC1 gene

Function
for FNDC1 gene

Pathways & Interactions
for FNDC1 gene

Drugs & Compounds
for FNDC1 gene

Transcripts
for FNDC1 gene

Expression
for FNDC1 gene

Orthologs
for FNDC1 gene

Paralogs
for FNDC1 gene

Genomic Variants
for FNDC1 gene

Disorders / Diseases
for FNDC1 gene

Publications
for FNDC1 gene

Intellectual Property
for FNDC1 gene

Products
for FNDC1 gene