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Aliases for FNDC1 Gene

Aliases for FNDC1 Gene

  • Fibronectin Type III Domain Containing 1 2 3
  • Fibronectin Type III Domain Containing 2 2 3
  • Expressed In Synovial Lining Protein 3 4
  • Activation-Associated CDNA Protein 3 4
  • KIAA1866 4 6
  • MEL4B3 3 4
  • FNDC2 3 4
  • AGS8 3 6
  • Fibronectin Type III Domain-Containing Protein 1 3
  • BA243O10.1 3
  • DJ322A24.1 3
  • EC 6.1.1.1 63
  • EC 2.7.2.3 63

External Ids for FNDC1 Gene

Previous HGNC Symbols for FNDC1 Gene

  • FNDC2

Previous GeneCards Identifiers for FNDC1 Gene

  • GC06P159484
  • GC06P159560
  • GC06P159609
  • GC06P159510
  • GC06P159590
  • GC06P157060

Summaries for FNDC1 Gene

GeneCards Summary for FNDC1 Gene

FNDC1 (Fibronectin Type III Domain Containing 1) is a Protein Coding gene. Diseases associated with FNDC1 include prostate leiomyosarcoma. An important paralog of this gene is ABI3BP.

UniProtKB/Swiss-Prot for FNDC1 Gene

  • May be an activator of G protein signaling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNDC1 Gene

Genomics for FNDC1 Gene

Regulatory Elements for FNDC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FNDC1 Gene

Start:
159,169,397 bp from pter
End:
159,272,109 bp from pter
Size:
102,713 bases
Orientation:
Plus strand

Genomic View for FNDC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FNDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNDC1 Gene

Proteins for FNDC1 Gene

  • Protein details for FNDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4ZHG4-FNDC1_HUMAN
    Recommended name:
    Fibronectin type III domain-containing protein 1
    Protein Accession:
    Q4ZHG4
    Secondary Accessions:
    • A6H8X2
    • B7ZBR4
    • B7ZBR5
    • B9EK49
    • Q5JPI0
    • Q5VU31
    • Q5VU32
    • Q5VXX4
    • Q70CQ6
    • Q96JG1

    Protein attributes for FNDC1 Gene

    Size:
    1894 amino acids
    Molecular mass:
    205558 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI46784.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI50608.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAY26234.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAE51894.1; Type=Frameshift; Positions=1487; Evidence={ECO:0000305}; Sequence=CAX14958.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FNDC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FNDC1 Gene

Proteomics data for FNDC1 Gene at MOPED

Selected DME Specific Peptides for FNDC1 Gene

Post-translational modifications for FNDC1 Gene

  • Glycosylation at Asn149, Ser713, Ser717, Thr732, Ser737, Ser738, Ser741, Ser759, Ser761, Thr762, Ser846, Ser847, Ser851, Thr852, Ser855, and Asn1661
  • Modification sites at PhosphoSitePlus

Other Protein References for FNDC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for FNDC1 Gene

Gene Families for FNDC1 Gene

HGNC:
  • FN3 :Fibronectin type III domain containing

Protein Domains for FNDC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FNDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4ZHG4

UniProtKB/Swiss-Prot:

FNDC1_HUMAN :
  • Q4ZHG4
Domain:
  • Contains 5 fibronectin type-III domains.
genes like me logo Genes that share domains with FNDC1: view

Function for FNDC1 Gene

Molecular function for FNDC1 Gene

UniProtKB/Swiss-Prot Function: May be an activator of G protein signaling.
UniProtKB/Swiss-Prot Induction: By TGFB1 present in the melanoma cell conditioned medium (MCCM).

Enzyme Numbers (IUBMB) for FNDC1 Gene

Gene Ontology (GO) - Molecular Function for FNDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FNDC1: view

Phenotypes for FNDC1 Gene

GenomeRNAi human phenotypes for FNDC1:
genes like me logo Genes that share phenotypes with FNDC1: view

Animal Model Products

CRISPR Products

miRNA for FNDC1 Gene

miRTarBase miRNAs that target FNDC1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for FNDC1 Gene

Localization for FNDC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNDC1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FNDC1 Gene COMPARTMENTS Subcellular localization image for FNDC1 gene
Compartment Confidence
extracellular 3
mitochondrion 2
plasma membrane 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FNDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with FNDC1: view

Pathways for FNDC1 Gene

SuperPathways for FNDC1 Gene

No Data Available

Interacting Proteins for FNDC1 Gene

Gene Ontology (GO) - Biological Process for FNDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0010666 positive regulation of cardiac muscle cell apoptotic process IEA --
GO:0051223 regulation of protein transport IEA --
GO:0071456 cellular response to hypoxia IEA --
genes like me logo Genes that share ontologies with FNDC1: view

No data available for Pathways by source for FNDC1 Gene

Transcripts for FNDC1 Gene

mRNA/cDNA for FNDC1 Gene

Unigene Clusters for FNDC1 Gene

Fibronectin type III domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FNDC1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FNDC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FNDC1 Gene

No ASD Table

Relevant External Links for FNDC1 Gene

GeneLoc Exon Structure for
FNDC1
ECgene alternative splicing isoforms for
FNDC1

Expression for FNDC1 Gene

mRNA expression in normal human tissues for FNDC1 Gene

mRNA differential expression in normal tissues according to GTEx for FNDC1 Gene

This gene is overexpressed in Thyroid (9.6) and Colon - Sigmoid (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FNDC1 Gene

SOURCE GeneReport for Unigene cluster for FNDC1 Gene Hs.520525

mRNA Expression by UniProt/SwissProt for FNDC1 Gene

Q4ZHG4-FNDC1_HUMAN
Tissue specificity: Almost absent from healthy skin; especially in epidermal keratinocytes, skin fibroblasts or endothelial cells and is barely detectable in benign melanocytic naevi. Expressed in the stroma close to skin tumors, in the tumor cells themselves and in the epidermis of psoriasis
genes like me logo Genes that share expressions with FNDC1: view

In Situ Assay Products

Orthologs for FNDC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FNDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FNDC1 35
  • 99.06 (n)
  • 98.48 (a)
FNDC1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FNDC1 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FNDC1 35
  • 80.57 (n)
  • 74.84 (a)
FNDC1 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fndc1 16
Fndc1 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FNDC1 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FNDC1 36
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fndc1 35
  • 76.51 (n)
  • 72.81 (a)
chicken
(Gallus gallus)
Aves FNDC1 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 92 (a)
OneToMany
-- 36
  • 37 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fndc1 36
  • 35 (a)
OneToOne
Species with no ortholog for FNDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FNDC1 Gene

ENSEMBL:
Gene Tree for FNDC1 (if available)
TreeFam:
Gene Tree for FNDC1 (if available)

Paralogs for FNDC1 Gene

Paralogs for FNDC1 Gene

genes like me logo Genes that share paralogs with FNDC1: view

Variants for FNDC1 Gene

Sequence variations from dbSNP and Humsavar for FNDC1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs172437 -- 159,205,711(-) CATAG(A/T)TTCAT intron-variant
rs186084 -- 159,199,478(-) TTTCA(C/T)AATAA intron-variant
rs188403 -- 159,250,252(-) AAATT(A/T)GTCTG intron-variant
rs211493 -- 159,254,349(-) atgaa(G/T)taaaa intron-variant
rs211494 -- 159,250,060(-) CTGCC(A/G)GGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FNDC1 Gene

Variant ID Type Subtype PubMed ID
nsv830850 CNV Gain 17160897
nsv886799 CNV Loss 21882294
nsv830851 CNV Gain 17160897
esv2733023 CNV Deletion 23290073
esv2287378 CNV Deletion 18987734
esv2733024 CNV Deletion 23290073
esv2665874 CNV Deletion 23128226
esv992188 CNV Deletion 20482838
esv1197817 CNV Deletion 17803354
esv2595923 CNV Deletion 19546169
esv2307373 CNV Deletion 18987734
esv4520 CNV Deletion 18987735
esv2733025 CNV Deletion 23290073
esv995554 CNV Deletion 20482838
esv2473194 CNV Deletion 19546169
esv1401887 CNV Deletion 17803354
esv22549 CNV Loss 19812545
nsv349266 CNV Loss 16902084

Relevant External Links for FNDC1 Gene

HapMap Linkage Disequilibrium report
FNDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNDC1 Gene

Disorders for FNDC1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for FNDC1 Gene including...

Search for FNDC1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for FNDC1 Gene

Relevant External Links for FNDC1

Genetic Association Database (GAD)
FNDC1
Human Genome Epidemiology (HuGE) Navigator
FNDC1
genes like me logo Genes that share disorders with FNDC1: view

No data available for UniProtKB/Swiss-Prot for FNDC1 Gene

Publications for FNDC1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. Use of differential subtraction method to identify genes that characterize the phenotype of cultured rheumatoid arthritis synoviocytes. (PMID: 9704633) Seki T. … Winchester R. (Arthritis Rheum. 1998) 3 4
  3. MEL4B3, a novel mRNA is induced in skin tumors and regulated by TGF- beta and pro-inflammatory cytokines. (PMID: 16098131) Anderegg U. … Saalbach A. (Exp. Dermatol. 2005) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease. (PMID: 21606135) Wild P.S. … Blankenberg S. (Circ Cardiovasc Genet 2011) 3 48

Products for FNDC1 Gene

Sources for FNDC1 Gene

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