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Aliases for FNBP4 Gene

Aliases for FNBP4 Gene

  • Formin Binding Protein 4 2 3
  • FBP30 3 4 6
  • Formin-Binding Protein 30 3 4
  • KIAA1014 4 6
  • Formin-Binding Protein 4 3

External Ids for FNBP4 Gene

Previous GeneCards Identifiers for FNBP4 Gene

  • GC11M048615
  • GC11M047769
  • GC11M047702
  • GC11M047694
  • GC11M047443
  • GC11M047805
  • GC11M048082
  • GC11M048805
  • GC11M049910

Summaries for FNBP4 Gene

GeneCards Summary for FNBP4 Gene

FNBP4 (Formin Binding Protein 4) is a Protein Coding gene. Diseases associated with FNBP4 include microphthalmia with limb anomalies.

Gene Wiki entry for FNBP4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNBP4 Gene

Genomics for FNBP4 Gene

Regulatory Elements for FNBP4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FNBP4 Gene

47,716,503 bp from pter
47,767,460 bp from pter
50,958 bases
Minus strand

Genomic View for FNBP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FNBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNBP4 Gene

Proteins for FNBP4 Gene

  • Protein details for FNBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Formin-binding protein 4
    Protein Accession:
    Secondary Accessions:
    • Q9H985
    • Q9NT81
    • Q9Y2L7

    Protein attributes for FNBP4 Gene

    1017 amino acids
    Molecular mass:
    110266 Da
    Quaternary structure:
    • Binds FMN1. Interacts with the Arg/Gly-rich-flanked Pro-rich of KHDRBS1/SAM68. Arginine methylation in these regions has no effect on this binding.
    • Sequence=BAA76858.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FNBP4 Gene


neXtProt entry for FNBP4 Gene

Proteomics data for FNBP4 Gene at MOPED

Post-translational modifications for FNBP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FNBP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FNBP4 Gene

Domains for FNBP4 Gene

Protein Domains for FNBP4 Gene


Suggested Antigen Peptide Sequences for FNBP4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8N3X1
  • These WW domains interact with Arg/Gly-rich-flanked Pro-rich domains found in several WW domain-binding proteins (WBPs). The N-terminal WW domain has the greater ligand-binding ability (By similarity).
  • Contains 2 WW domains.
genes like me logo Genes that share domains with FNBP4: view

No data available for Gene Families for FNBP4 Gene

Function for FNBP4 Gene

Gene Ontology (GO) - Molecular Function for FNBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17500595
genes like me logo Genes that share ontologies with FNBP4: view

Phenotypes for FNBP4 Gene

GenomeRNAi human phenotypes for FNBP4:
genes like me logo Genes that share phenotypes with FNBP4: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FNBP4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FNBP4 Gene

Localization for FNBP4 Gene

Subcellular locations from

Jensen Localization Image for FNBP4 Gene COMPARTMENTS Subcellular localization image for FNBP4 gene
Compartment Confidence
nucleus 4
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FNBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with FNBP4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FNBP4 Gene

Pathways for FNBP4 Gene

SuperPathways for FNBP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FNBP4 Gene


No data available for Pathways by source for FNBP4 Gene

Transcripts for FNBP4 Gene

Unigene Clusters for FNBP4 Gene

Formin binding protein 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FNBP4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FNBP4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^
SP1: - -
SP4: - - -
SP5: - -
SP8: - -
SP10: - - -
SP11: - -
SP12: -
SP17: -

ExUns: 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23
SP1: - - - - -
SP5: -
SP7: - - - -
SP9: - - - -
SP13: - - -
SP15: - -
SP18: -

Relevant External Links for FNBP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FNBP4 Gene

mRNA expression in normal human tissues for FNBP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for FNBP4 Gene

This gene is overexpressed in CD8 Tcells (12.9), Monocytes (11.9), and Testis (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FNBP4 Gene

SOURCE GeneReport for Unigene cluster for FNBP4 Gene Hs.6834

genes like me logo Genes that share expressions with FNBP4: view

Expression partners for FNBP4 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FNBP4 Gene

Orthologs for FNBP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FNBP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FNBP4 35
  • 88.16 (n)
  • 89.74 (a)
FNBP4 36
  • 88 (a)
(Canis familiaris)
Mammalia FNBP4 35
  • 91.2 (n)
  • 92.41 (a)
FNBP4 36
  • 93 (a)
(Mus musculus)
Mammalia Fnbp4 35
  • 83.81 (n)
  • 83.84 (a)
Fnbp4 16
Fnbp4 36
  • 82 (a)
(Pan troglodytes)
Mammalia FNBP4 35
  • 99.71 (n)
  • 99.71 (a)
FNBP4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fnbp4 35
  • 85.05 (n)
  • 85.91 (a)
(Monodelphis domestica)
Mammalia FNBP4 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia FNBP4 36
  • 80 (a)
(Gallus gallus)
Aves FNBP4 35
  • 65.12 (n)
  • 66.74 (a)
FNBP4 36
  • 61 (a)
(Anolis carolinensis)
Reptilia FNBP4 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC734003 35
  • 63.53 (n)
  • 63.28 (a)
Str.10228 35
African clawed frog
(Xenopus laevis)
Amphibia fnbp4-prov 35
(Danio rerio)
Actinopterygii Dr.15154 35
fnbp4 35
  • 59.03 (n)
  • 56.82 (a)
fnbp4 36
  • 55 (a)
Species with no ortholog for FNBP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FNBP4 Gene

Gene Tree for FNBP4 (if available)
Gene Tree for FNBP4 (if available)

Paralogs for FNBP4 Gene

Selected SIMAP similar genes for FNBP4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FNBP4: view

No data available for Paralogs for FNBP4 Gene

Variants for FNBP4 Gene

Sequence variations from dbSNP and Humsavar for FNBP4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1023895 -- 47,717,382(+) ACACA(A/C)AACAC utr-variant-3-prime
rs1123210 -- 47,743,122(+) ATCCA(C/T)AAAAG intron-variant
rs1563821 -- 47,735,016(+) CACAG(C/T)ATGGT intron-variant
rs1975856 -- 47,734,989(+) ccccc(A/C)aaaaa intron-variant
rs2045615 -- 47,717,934(+) ttttt(A/T)agtag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FNBP4 Gene

Variant ID Type Subtype PubMed ID
nsv469858 CNV Gain 16826518
nsv832143 CNV Loss 17160897
esv2676370 CNV Deletion 23128226

Relevant External Links for FNBP4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FNBP4 Gene

Disorders for FNBP4 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for FNBP4 Gene in MalaCards »

(1) Diseases for FNBP4 Gene including...

genes like me logo Genes that share disorders with FNBP4: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FNBP4 Gene

Publications for FNBP4 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains. (PMID: 10748127) Bedford M.T. … Richard S. (J. Biol. Chem. 2000) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  5. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 3

Products for FNBP4 Gene

Sources for FNBP4 Gene

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