Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FNBP1L Gene

Aliases for FNBP1L Gene

  • Formin Binding Protein 1 Like 2 3
  • Formin Binding Protein 1-Like 2 3 5
  • Transducer Of Cdc42-Dependent Actin Assembly Protein 1 3 4
  • C1orf39 3 4
  • Toca-1 3 4
  • TOCA1 3 4
  • Transducer Of Cdc42-Dependent Actin Assembly 1 3
  • Chromosome 1 Open Reading Frame 39 2

External Ids for FNBP1L Gene

Previous HGNC Symbols for FNBP1L Gene

  • C1orf39

Previous GeneCards Identifiers for FNBP1L Gene

  • GC01P093626
  • GC01P093737
  • GC01P093913
  • GC01P092035

Summaries for FNBP1L Gene

Entrez Gene Summary for FNBP1L Gene

  • The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for FNBP1L Gene

FNBP1L (Formin Binding Protein 1 Like) is a Protein Coding gene. Among its related pathways are Actin Nucleation by ARP-WASP Complex. GO annotations related to this gene include lipid binding. An important paralog of this gene is TRIP10.

UniProtKB/Swiss-Prot for FNBP1L Gene

  • Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.

Gene Wiki entry for FNBP1L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FNBP1L Gene

Genomics for FNBP1L Gene

Regulatory Elements for FNBP1L Gene

Enhancers for FNBP1L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FNBP1L on UCSC Golden Path with GeneCards custom track

Promoters for FNBP1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FNBP1L on UCSC Golden Path with GeneCards custom track

Genomic Location for FNBP1L Gene

Chromosome:
1
Start:
93,448,076 bp from pter
End:
93,570,905 bp from pter
Size:
122,830 bases
Orientation:
Plus strand

Genomic View for FNBP1L Gene

Genes around FNBP1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FNBP1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FNBP1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FNBP1L Gene

Proteins for FNBP1L Gene

  • Protein details for FNBP1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T0N5-FBP1L_HUMAN
    Recommended name:
    Formin-binding protein 1-like
    Protein Accession:
    Q5T0N5
    Secondary Accessions:
    • J3QSS4
    • Q5T0N6
    • Q6B097
    • Q6P653
    • Q6R4Q4
    • Q9NXG1

    Protein attributes for FNBP1L Gene

    Size:
    605 amino acids
    Molecular mass:
    70065 Da
    Quaternary structure:
    • Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures (By similarity). Interacts with GTP-bound CDC42. Interacts with DAAM1, DIAPH1, DIAPH2, DNM1, DNM2 and WASL/N-WASP. Interacts with ATG3.
    SequenceCaution:
    • Sequence=BAA91051.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FNBP1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FNBP1L Gene

Proteomics data for FNBP1L Gene at MOPED

Post-translational modifications for FNBP1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FNBP1L Gene

Antibody Products

No data available for DME Specific Peptides for FNBP1L Gene

Domains & Families for FNBP1L Gene

Suggested Antigen Peptide Sequences for FNBP1L Gene

Graphical View of Domain Structure for InterPro Entry

Q5T0N5

UniProtKB/Swiss-Prot:

FBP1L_HUMAN :
  • The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation (By similarity).
  • Belongs to the FNBP1 family.
  • Contains 1 REM (Hr1) repeat.
Domain:
  • The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation (By similarity).
  • Contains 1 F-BAR domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the FNBP1 family.
Similarity:
  • Contains 1 REM (Hr1) repeat.
genes like me logo Genes that share domains with FNBP1L: view

No data available for Gene Families for FNBP1L Gene

Function for FNBP1L Gene

Molecular function for FNBP1L Gene

UniProtKB/Swiss-Prot Function:
Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.
genes like me logo Genes that share phenotypes with FNBP1L: view

Animal Model Products

miRNA for FNBP1L Gene

miRTarBase miRNAs that target FNBP1L

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FNBP1L Gene

Localization for FNBP1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for FNBP1L Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FNBP1L Gene COMPARTMENTS Subcellular localization image for FNBP1L gene
Compartment Confidence
extracellular 5
cytoskeleton 4
golgi apparatus 4
plasma membrane 4
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FNBP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016023 cytoplasmic, membrane-bounded vesicle IDA 20730103
genes like me logo Genes that share ontologies with FNBP1L: view

Pathways & Interactions for FNBP1L Gene

SuperPathways for FNBP1L Gene

Superpath Contained pathways
1 Actin Nucleation by ARP-WASP Complex
genes like me logo Genes that share pathways with FNBP1L: view

Pathways by source for FNBP1L Gene

1 Qiagen pathway for FNBP1L Gene

Gene Ontology (GO) - Biological Process for FNBP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0016050 vesicle organization IDA 20730103
GO:0043547 positive regulation of GTPase activity IBA --
genes like me logo Genes that share ontologies with FNBP1L: view

No data available for SIGNOR curated interactions for FNBP1L Gene

Drugs & Compounds for FNBP1L Gene

(1) Drugs for FNBP1L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(124) Additional Compounds for FNBP1L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PS(14:0/14:0)
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(14:0/14:0)
  • PS(28:0)
PS(14:0/14:1(9Z))
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1w5)
  • Phosphatidylserine(28:1)
PS(14:0/16:0)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(14:0/16:0)
  • PS(30:0)
PS(14:0/16:1(9Z))
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1w7)
  • Phosphatidylserine(30:1)
PS(14:0/18:0)
  • 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/18:0)
  • Phosphatidylserine(32:0)
  • PS(14:0/18:0)
  • PS(32:0)
genes like me logo Genes that share compounds with FNBP1L: view

Transcripts for FNBP1L Gene

Unigene Clusters for FNBP1L Gene

Formin binding protein 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FNBP1L Gene

No ASD Table

Relevant External Links for FNBP1L Gene

GeneLoc Exon Structure for
FNBP1L
ECgene alternative splicing isoforms for
FNBP1L

Expression for FNBP1L Gene

mRNA expression in normal human tissues for FNBP1L Gene

Protein differential expression in normal tissues from HIPED for FNBP1L Gene

This gene is overexpressed in Fetal Brain (18.0), Peripheral blood mononuclear cells (8.7), Islet of Langerhans (7.2), and Platelet (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FNBP1L Gene



SOURCE GeneReport for Unigene cluster for FNBP1L Gene Hs.134060

genes like me logo Genes that share expression patterns with FNBP1L: view

Protein tissue co-expression partners for FNBP1L Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FNBP1L Gene

Orthologs for FNBP1L Gene

This gene was present in the common ancestor of animals.

Orthologs for FNBP1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FNBP1L 35
  • 99.82 (n)
  • 99.82 (a)
FNBP1L 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FNBP1L 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FNBP1L 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FNBP1L 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fnbp1l 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FNBP1L 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves FNBP1L 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FNBP1L 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fnbp1l 35
  • 77.39 (n)
  • 85.82 (a)
Str.20339 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.33887 35
zebrafish
(Danio rerio)
Actinopterygii fnbp1l 35
  • 70.74 (n)
  • 77.37 (a)
fnbp1l 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cip4 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea toca-1 36
  • 25 (a)
ManyToMany
toca-2 36
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for FNBP1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FNBP1L Gene

ENSEMBL:
Gene Tree for FNBP1L (if available)
TreeFam:
Gene Tree for FNBP1L (if available)

Paralogs for FNBP1L Gene

Paralogs for FNBP1L Gene

(4) SIMAP similar genes for FNBP1L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FNBP1L: view

Variants for FNBP1L Gene

Sequence variations from dbSNP and Humsavar for FNBP1L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3595 -- 93,554,544(+) AAAAT(A/C/G/T)ACCAA intron-variant, utr-variant-3-prime
rs142933 -- 93,549,007(-) TCACT(C/G)GGTCT intron-variant
rs237424 -- 93,545,258(-) atgtt(C/T)ctcat intron-variant
rs237425 -- 93,546,730(-) AGTCA(C/T)ATCTT intron-variant
rs237426 -- 93,546,822(-) GAACC(A/C)CAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FNBP1L Gene

Variant ID Type Subtype PubMed ID
nsv871640 CNV Loss 21882294

Variation tolerance for FNBP1L Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.14% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FNBP1L Gene

Disorders for FNBP1L Gene

Relevant External Links for FNBP1L

Genetic Association Database (GAD)
FNBP1L
Human Genome Epidemiology (HuGE) Navigator
FNBP1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FNBP1L

No disorders were found for FNBP1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FNBP1L Gene

Publications for FNBP1L Gene

  1. Identification and characterization of human FNBP1L gene in silico. (PMID: 14654988) Katoh M. … Katoh M. (Int. J. Mol. Med. 2004) 2 3 23 67
  2. The Toca-1-N-WASP complex links filopodial formation to endocytosis. (PMID: 19213734) Bu W. … Ahmed S. (J. Biol. Chem. 2009) 3 23
  3. A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy. (PMID: 19342671) Huett A. … Xavier R.J. (J. Immunol. 2009) 3 23
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for FNBP1L Gene

Sources for FNBP1L Gene

Content