Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FNBP1L Gene

protein-coding   GIFtS: 51
GCID: GC01P093913

formin binding protein 1-like

(Previous name: chromosome 1 open reading frame 39 )
(Previous symbol: C1orf39)
 Explore 1 disease affiliated with
FNBP1L via our new
 Human Malady Compendium 
Biological research products
for FNBP1L
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Formin Binding Protein 1-Like1 2     Chromosome 1 Open Reading Frame 391
C1orf391 2 3     Formin-Binding Protein 1-Like2
TOCA11 2 3     Toca-13
Transducer Of Cdc42-Dependent Actin Assembly Protein 12 3     Transducer Of Cdc42-Dependent Actin Assembly 12
FLJ202751     Toca-13

External Ids:    HGNC: 208511   Entrez Gene: 548742   Ensembl: ENSG000001379427   OMIM: 6088485   UniProtKB: Q5T0N53   

Export aliases for FNBP1L gene to outside databases

Previous GC identifers: GC01P093626 GC01P093737 GC01P092035


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FNBP1L:
The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin
polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface
signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different
isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FBP1L_HUMAN, Q5T0N5
Function: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis.
May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane
invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the
WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the
fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens

Gene Wiki entry for FNBP1L


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FNBP1L gene promoter:
         STAT5B   ISGF-3   p53   Nkx2-2   Ik-3   SRY   POU2F1   POU2F1a   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFNBP1L promoter sequence
   Search SABiosciences Chromatin IP Primers for FNBP1L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FNBP1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.1   Ensembl cytogenetic band:  1p22.1   HGNC cytogenetic band: 1p22.1

FNBP1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FNBP1L gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P093913:  view genomic region     (about GC identifiers)

Start:
93,913,658 bp from pter      End:
94,020,218 bp from pter
Size:
106,561 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FBP1L_HUMAN, Q5T0N5 (See protein sequence)
Recommended Name: Formin-binding protein 1-like  
Size: 605 amino acids; 69977 Da
Subunit: Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures (By similarity). Interacts
with GTP-bound CDC42. Interacts with DAAM1, DIAPH1, DIAPH2, DNM1, DNM2 and WASL/N-WASP. Interacts with ATG3
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cell cortex (By similarity).
Cytoplasmic vesicle (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity)
Sequence caution: Sequence=BAA91051.1; Type=Erroneous initiation; Sequence=CAI18954.1; Type=Erroneous gene model
prediction; Sequence=CAI18981.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5T0N6 Q6B097 Q6P653 Q6R4Q4 Q9NXG1
Alternative splicing: 5 isoforms:  Q5T0N5-1   Q5T0N5-2   Q5T0N5-3   Q5T0N5-4   Q5T0N5-5   (Gene prediction based on EST data. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FNBP1L: NX_Q5T0N5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5T0N5

  • FNBP1L Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001020119.1  NP_001157945.1  NP_060207.2  

    ENSEMBL proteins: 
     ENSP00000359278   ENSP00000359275   ENSP00000397451   ENSP00000271234   ENSP00000260506  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for FNBP1L 
    GenScript Custom Purified and Recombinant Proteins Services for FNBP1L
    Novus Biologicals FNBP1L Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FNBP1L

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane IEA--
    GO:0005938cell cortex IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle IDA--


    FNBP1L for ontologies           About GeneDecksing



    FNBP1L Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of FNBP1L
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 2): FNBP1L
    OriGene Custom Antibody Services for FNBP1L 
    GenScript Custom Superior Antibodies Services for FNBP1L
    Novus Biologicals FNBP1L Antibodies
    Search for Antibodies for FNBP1L at Abcam  
    Uscn Antibodies for FNBP1L
    ThermoFisher Antibodies for FNBP1L

    Assay Products for FNBP1L: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FNBP1L
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for FNBP1L


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FNBP1L for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001060 FCH
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q5T0N5

    ProtoNet protein and cluster: Q5T0N5

    2 Blocks protein families:
    IPB001060 Cdc15/Fes/CIP4
    IPB003016 2-oxo acid dehydrogenase


    UniProtKB/Swiss-Prot: FBP1L_HUMAN, Q5T0N5
    Domain: The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of
    dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive
    tubulation (By similarity)
    Similarity: Belongs to the FNBP1 family
    Similarity: Contains 1 FCH domain
    Similarity: Contains 1 REM (Hr1) repeat
    Similarity: Contains 1 SH3 domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: FBP1L_HUMAN, Q5T0N5
    Function: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis.
    May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane
    invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the
    WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the
    fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 3): FNBP1L
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FNBP1L
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate FNBP1L (see all 57):
    hsa-miR-411* hsa-miR-379* hsa-miR-106a hsa-miR-200a hsa-miR-4305 hsa-miR-519a hsa-miR-502-3p hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidFNBP1L 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FNBP1L (see all 7)
    OriGene shRNA RFP: FNBP1L
    OriGene siRNA: FNBP1L
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FNBP1L

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FNBP1L

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNBP1L (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNBP1L (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): FNBP1L (NM_017737)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FNBP1L
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FNBP1L 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FNBP1L
    Search LifeMap BioReagents cell lines for FNBP1L

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNBP1L

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008289lipid binding IEA--


    FNBP1L for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for FNBP1L:
     Decreased number of cells in m 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FNBP1L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/92 Interacting proteins for FNBP1L (Q5T0N52, 3 ENSP000002712344) via UniProtKB, MINT, STRING, and/or I2D (see all 92)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DAAM1Q9Y4D12, 3, ENSP000002471704MINT-7146145 MINT-7146222 I2D: score=1 STRING: ENSP00000247170
    USP13Q929952, 3MINT-65085 I2D: score=5 
    SGSM2O431472, 3, ENSP000002689894MINT-64873 I2D: score=5 STRING: ENSP00000268989
    CDC42P609533, ENSP000003144584I2D: score=1 STRING: ENSP00000314458
    WASLO004013, ENSP000002230234I2D: score=1 STRING: ENSP00000223023
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006900membrane budding IDA--
    GO:0006914autophagy IEA--
    GO:0010324membrane invagination IDA--
    GO:0016050vesicle organization IDA--
    GO:0030050vesicle transport along actin filament IDA--


    FNBP1L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FNBP1L

    10/125 HMDB Compounds for FNBP1L (see all 125)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    PS(14:0/14:0)Phosphatidylserine(14:0/14:0) (see all 7)----
    PS(14:0/14:1(9Z))Phosphatidylserine(14:0/14:1n5) (see all 13)----
    PS(14:0/16:0)1-myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine (see all 7)----
    PS(14:0/16:1(9Z))PS(14:0/16:1n7) (see all 13)----
    PS(14:0/18:0)Phosphatidylserine(32:0) (see all 7)----
    PS(14:0/18:1(9Z))PSer(14:0/18:1n9) (see all 13)----
    PS(14:0/18:2(9Z,12Z))PS(14:0/18:2) (see all 13)----
    PS(14:0/18:3(9Z,12Z,15Z))Phosphatidylserine(14:0/18:3) (see all 14)----
    PS(14:0/20:3(8Z,11Z,14Z))PSer(14:0/20:3) (see all 14)----
    Search CenterWatch for drugs/clinical trials and news about FNBP1L / FBP1L 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FNBP1L gene (3 alternative transcripts): 
    NM_001024948.2  NM_001164473.2  NM_017737.4  

    Unigene Cluster for FNBP1L:

    Formin binding protein 1-like
    Hs.743249  [show with all ESTs]
    Unigene Representative Sequence: NM_001024948
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370256(uc001dpv.3 uc010otl.2) ENST00000370253 ENST00000424449
    ENST00000271234(uc010otk.2) ENST00000260506(uc001dpw.3)

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 3): FNBP1L
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FNBP1L
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate FNBP1L (see all 57):
    hsa-miR-411* hsa-miR-379* hsa-miR-106a hsa-miR-200a hsa-miR-4305 hsa-miR-519a hsa-miR-502-3p hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidFNBP1L 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FNBP1L (see all 7)
    OriGene shRNA RFP: FNBP1L
    OriGene siRNA: FNBP1L
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FNBP1L
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNBP1L (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNBP1L (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): FNBP1L (NM_017737)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FNBP1L
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FNBP1L 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FNBP1L
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FNBP1L
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FNBP1L
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FNBP1L

    Additional cDNA sequence: 

    AK000282.1 AK025526.1 AK026988.1 AK296767.1 AK299760.1 AK299943.1 AK315981.1 AY514449.1 
    BC062477.1 BC074891.2 BC074892.2 

    9 DOTS entries:

    DT.451610  DT.100752116  DT.99982744  DT.121365406  DT.40132926  DT.97785346  DT.95214915  DT.121365381 
    DT.99990332 

    24/202 AceView cDNA sequences (see all 202):

    AW190720 BC062477 BX507269 AI949924 AI333211 BQ573837 BG261286 AI288494 
    BX478678 F09853 Z40709 CK430000 AA099176 CR612845 AA448857 BM790762 
    CB129032 AI672317 BU521959 BC074891 AK000282 BX418915 D58132 AI142290 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FNBP1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See FNBP1L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FNBP1L

    SOURCE GeneReport for Unigene cluster: Hs.743249
        SABiosciences Expression via Pathway-Focused PCR Array including FNBP1L: 
              Cytoskeleton Regulators in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FNBP1L
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FNBP1L
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FNBP1L
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FNBP1L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNBP1L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FNBP1L gene from 7/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves FNBP1L6
    Uncharacterized protein
    93(a)
    1 ↔ 1
    8(14564698-14593336)
    lizard
    (Anolis carolinensis)
    Reptilia FNBP1L6
    --
    89(a)
    1 ↔ 1
    4(88347813-88394480)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.338872 Xenopus laevis transcribed sequence with moderate similarity more 78.03(n)    BJ617609.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK030078.12   -- 75.75(n)    CK030078.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cip41 CG15015-PA 48.5(n)
    41.17(a)
      38534  NM_139636.3  NP_647893.2 
    worm
    (Caenorhabditis elegans)
    Secernentea toca-16
    toca-26
    TOCA (Transducer Of Cdc42-dependent Actin assembly...
    TOCA (Transducer Of Cdc42-dependent Actin assembly...
    24(a)
    19(a)
    many ↔ many
    many ↔ many
    X(1511063-1521482)
    III(13755841-13759350)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BZZ11 Bzz1p 39.2(n)
    21.8(a)
      856514   NP_011982.1 


    ENSEMBL Gene Tree for FNBP1L (if available)
    TreeFam Gene Tree for FNBP1L (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FNBP1L gene
    TRIP102  FNBP12  
    4 SIMAP similar genes for FNBP1L using alignment to 2 protein entries:     FBP1L_HUMAN (see all proteins):
    FNBP1    TRIP10    STP    NCKIPSD

    FNBP1L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1430 NCBI SNPs in FNBP1L are shown (see all 1430    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs341737351,2
    C--92111615(+) GATTC-/TTTTTT 1 -- int12Minor allele frequency- T:0.25NA 4
    rs348147651,2
    C,--92120116(+) AATAA-/TTATCT 1 -- int12Minor allele frequency- T:0.25NA 4
    rs1883428881,2
    --93911863(+) CTTGAG/TATCAG 3 -- us2k10--------
    rs1496916061,2
    --93911892(+) GCCAAC/TATGGT 3 -- us2k10--------
    rs1170542281,2
    F,--93911911(+) ATCTCC/TACTAA 3 -- us2k11Minor allele frequency- T:0.02EA 120
    rs1912361281,2
    --93911922(+) AAACAC/TAAAAT 3 -- us2k10--------
    rs75419841,2
    C,F,A,--93911952(+) ggcgcA/Ctgtaa 3 -- us2k16Minor allele frequency- C:0.40NA WA CSA 10
    rs1488791841,2
    --93911984(+) AGGCAA/GGAGAA 3 -- us2k10--------
    rs171099541,2
    C,F,H,--93912195(+) AGGTGA/TCATAA 3 -- us2k112Minor allele frequency- T:0.10NA NS EA WA 684
    rs1838267981,2
    --93912255(+) AAAGTA/GTTGTT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for FNBP1L (93913658 - 94020218 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FNBP1L: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FNBP1L
    DNA2.0 Custom Variant and Variant Library Synthesis for FNBP1L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FNBP1L for disorders           About GeneDecksing

    OMIM gene information: 608848    OMIM disorders: --

    1 disease for FNBP1L:    About MalaCards
    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: FNBP1L (1 document)

    Export disorders for FNBP1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FNBP1L gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with FNBP1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human FNBP1L gene in silico. (PubMed id 14654988)1, 3, 9 Katoh M. and Katoh M. (2004)
    2. A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy. (PubMed id 19342671)1, 2, 9 Huett A....Xavier R.J. (2009)
    3. Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis. (PubMed id 16418535)1, 2 Tsujita K....Takenawa T. (2006)
    4. The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics. (PubMed id 16630611)1, 2 Aspenstroem P.... Johansson A.-S. (2006)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. Tuba stimulates intracellular N-WASP-dependent actin assembly. (PubMed id 16757518)1, 2 Kovacs E.M.... Gertler F.B. (2006)
    7. Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins. (PubMed id 16326391)1, 2 Itoh T....De Camilli P. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Toca-1 mediates Cdc42-dependent actin nucleation by activating the N- WASP-WIP complex. (PubMed id 15260990)1, 2 Ho H.-Y.H....Kirschner M.W. (2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54874 HGNC: 20851 AceView: C1orf39 Ensembl:ENSG00000137942 euGenes: HUgn54874
    ECgene: FNBP1L H-InvDB: FNBP1L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FNBP1L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FNBP1L gene:
    Search GeneIP for patents involving FNBP1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of FNBP1L
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for FNBP1L   OriGene shRNA RFP for FNBP1L  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FNBP1L   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FNBP1L  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for FNBP1L   OriGene 3'-UTR Clone for FNBP1L  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FNBP1L   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FNBP1L  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FNBP1L   OriGene Custom Protein Services for FNBP1L  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FNBP1L
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FNBP1L
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FNBP1L
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FNBP1L
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FNBP1L
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FNBP1L
     GenScript Custom Purified and Recombinant Proteins Services for FNBP1L GenScript cDNA clones with any tag delivered in your preferred vector for FNBP1L
     GenScript Custom Assay Services for FNBP1L GenScript Custom Superior Antibodies Services for FNBP1L
     GenScript Custom overexpressing Cell Line Services for FNBP1L CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FNBP1L promoter
     Search Chromatin IP Primers for FNBP1L
     RT2 qPCR Primer Assay in human, mouse, rat FNBP1L
     GNC Network for FNBP1L
     SABiosciences PCR Arrays including human, mouse, rat FNBP1L
     Search Tocris compounds for FNBP1L
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FNBP1L antibodies
     FNBP1L proteins
     Search for Antibodies for FNBP1L at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for FNBP1L
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     FNBP1L Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for FNBP1L
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FNBP1L
     SwitchGear 3'UTR luciferase reporter plasmids for FNBP1L
     SwitchGear Promoter luciferase reporter plasmids for FNBP1L
     ThermoFisher Antibodies for FNBP1L
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FNBP1L
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FNBP1L gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4