Aliases for FNBP1 Gene
External Ids for FNBP1 Gene
Previous GeneCards Identifiers for FNBP1 Gene
The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. [provided by RefSeq, Jul 2008]
GeneCards Summary for FNBP1 Gene
FNBP1 (Formin Binding Protein 1) is a Protein Coding gene. Diseases associated with FNBP1 include Persistent Hyperplastic Primary Vitreous. GO annotations related to this gene include identical protein binding and structural constituent of ribosome. An important paralog of this gene is FNBP1L.
UniProtKB/Swiss-Prot for FNBP1 Gene
May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.