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Aliases for FN3KRP Gene

Aliases for FN3KRP Gene

  • Fructosamine 3 Kinase Related Protein 2 3
  • Fructosamine-3-Kinase-Related Protein 3 4
  • FN3K-Related Protein 3 4
  • FN3K-RP 3 4
  • Ketosamine-3-Kinase 3
  • EC 2.7.1.- 4
  • FN3KL 3

External Ids for FN3KRP Gene

Summaries for FN3KRP Gene

Entrez Gene Summary for FN3KRP Gene

  • A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

GeneCards Summary for FN3KRP Gene

FN3KRP (Fructosamine 3 Kinase Related Protein) is a Protein Coding gene. GO annotations related to this gene include kinase activity. An important paralog of this gene is FN3K.

UniProtKB/Swiss-Prot for FN3KRP Gene

  • Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein-bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation.

Gene Wiki entry for FN3KRP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FN3KRP Gene

Genomics for FN3KRP Gene

Genomic Location for FN3KRP Gene

Start:
82,716,683 bp from pter
End:
82,730,328 bp from pter
Size:
13,646 bases
Orientation:
Plus strand

Genomic View for FN3KRP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FN3KRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FN3KRP Gene

Regulatory Elements for FN3KRP Gene

Proteins for FN3KRP Gene

  • Protein details for FN3KRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HA64-KT3K_HUMAN
    Recommended name:
    Ketosamine-3-kinase
    Protein Accession:
    Q9HA64
    Secondary Accessions:
    • Q969F4
    • Q9H0U7

    Protein attributes for FN3KRP Gene

    Size:
    309 amino acids
    Molecular mass:
    34412 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB66566.1; Type=Erroneous termination; Positions=198; Note=Translated as Leu.; Evidence={ECO:0000305};

neXtProt entry for FN3KRP Gene

Proteomics data for FN3KRP Gene at MOPED

Post-translational modifications for FN3KRP Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys45

Other Protein References for FN3KRP Gene

No data available for DME Specific Peptides for FN3KRP Gene

Domains for FN3KRP Gene

UniProtKB/Swiss-Prot:

KT3K_HUMAN
Family:
  • Belongs to the fructosamine kinase family.:
    • Q9HA64
genes like me logo Genes that share domains with FN3KRP: view

No data available for Gene Families for FN3KRP Gene

Function for FN3KRP Gene

Molecular function for FN3KRP Gene

UniProtKB/Swiss-Prot Function: Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein-bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation.

Enzyme Numbers (IUBMB) for FN3KRP Gene

Gene Ontology (GO) - Molecular Function for FN3KRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016301 kinase activity IBA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with FN3KRP: view

Phenotypes for FN3KRP Gene

genes like me logo Genes that share phenotypes with FN3KRP: view

miRNA for FN3KRP Gene

miRTarBase miRNAs that target FN3KRP

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for FN3KRP Gene

Localization for FN3KRP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FN3KRP Gene COMPARTMENTS Subcellular localization image for FN3KRP gene
Compartment Confidence
chloroplast 2
cytosol 2
nucleus 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for FN3KRP Gene

Pathways for FN3KRP Gene

SuperPathways for FN3KRP Gene

No Data Available

Interacting Proteins for FN3KRP Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000269373%0d%0a9606.ENSP00000285199%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000384109%0d%0a
Selected Interacting proteins: ENSP00000269373 Q9HA64-KT3K_HUMAN for FN3KRP Gene via STRING I2D

Gene Ontology (GO) - Biological Process for FN3KRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0016310 phosphorylation IBA --
genes like me logo Genes that share ontologies with FN3KRP: view

No data available for Pathways by source for FN3KRP Gene

Compounds for FN3KRP Gene

(1) HMDB Compounds for FN3KRP Gene

Compound Synonyms Cas Number PubMed IDs
Fructosamine
  • 1-Amino-1-deoxy-D-fructose
4429-04-3

(5) Novoseek inferred chemical compound relationships for FN3KRP Gene

Compound -log(P) Hits PubMed IDs
1-deoxy-1-morpholinofructose 97.1 2
fructosamine 79.9 6
ribose 60.8 1
glucose 33.4 3
carbon 15.5 2
genes like me logo Genes that share compounds with FN3KRP: view

Transcripts for FN3KRP Gene

Unigene Clusters for FN3KRP Gene

Fructosamine 3 kinase related protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FN3KRP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2:
SP3: - - -

Relevant External Links for FN3KRP Gene

GeneLoc Exon Structure for
FN3KRP
ECgene alternative splicing isoforms for
FN3KRP

Expression for FN3KRP Gene

mRNA expression in normal human tissues for FN3KRP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FN3KRP Gene

SOURCE GeneReport for Unigene cluster for FN3KRP Gene Hs.31431

mRNA Expression by UniProt/SwissProt for FN3KRP Gene

Q9HA64-KT3K_HUMAN
Tissue specificity: Expressed in erythrocytes.
genes like me logo Genes that share expressions with FN3KRP: view

Orthologs for FN3KRP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FN3KRP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FN3KRP 36
  • 99.14 (n)
  • 98.71 (a)
FN3KRP 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FN3KRP 36
  • 86.58 (n)
  • 87.01 (a)
FN3KRP 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FN3KRP 36
  • 85.54 (n)
  • 86.73 (a)
FN3KRP 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fn3krp 36
  • 85.33 (n)
  • 89 (a)
Fn3krp 16
Fn3krp 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FN3KRP 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FN3KRP 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fn3krp 36
  • 84.47 (n)
  • 88.35 (a)
chicken
(Gallus gallus)
Aves FN3KRP 36
  • 72.92 (n)
  • 78.96 (a)
FN3KRP 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FN3KRP 37
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fn3krp 36
  • 69.26 (n)
  • 69.26 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11207 36
zebrafish
(Danio rerio)
Actinopterygii fn3krp 36
  • 66.56 (n)
  • 70.82 (a)
fn3krp 37
  • 70 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_Y116A8C.25 36
  • 45.83 (n)
  • 39.34 (a)
Y116A8C.25 37
  • 33 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G61080 36
  • 48.36 (n)
  • 41.9 (a)
rice
(Oryza sativa)
Liliopsida Os03g0117800 36
  • 50 (n)
  • 42.28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 48 (a)
OneToMany
Species with no ortholog for FN3KRP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FN3KRP Gene

ENSEMBL:
Gene Tree for FN3KRP (if available)
TreeFam:
Gene Tree for FN3KRP (if available)

Paralogs for FN3KRP Gene

Paralogs for FN3KRP Gene

Selected SIMAP similar genes for FN3KRP Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with FN3KRP: view

Variants for FN3KRP Gene

Sequence variations from dbSNP and Humsavar for FN3KRP Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs7794 -- 82,727,784(+) ATAGG(A/G)TGTCC utr-variant-3-prime, nc-transcript-variant
rs12296 -- 82,727,890(-) GCATG(C/T)ATTTT utr-variant-3-prime, nc-transcript-variant
rs13955 -- 82,726,978(+) TGAGC(C/T)GGCAA missense, reference, nc-transcript-variant
rs1046875 -- 82,727,550(+) TTTCC(A/G)CTGCC utr-variant-3-prime, nc-transcript-variant
rs1046889 -- 82,727,635(+) GTAGA(C/T)ATGAA utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for FN3KRP Gene

Variant ID Type Subtype PubMed ID
nsv428351 CNV Gain 18775914
esv21913 CNV Gain+Loss 19812545
nsv909240 CNV Loss 21882294
dgv3363n71 CNV Loss 21882294
nsv909243 CNV Loss 21882294
nsv833575 CNV Loss 17160897
nsv909244 CNV Loss 21882294
esv2716524 CNV Deletion 23290073

Relevant External Links for FN3KRP Gene

HapMap Linkage Disequilibrium report
FN3KRP
Human Gene Mutation Database (HGMD)
FN3KRP

Disorders for FN3KRP Gene

Relevant External Links for FN3KRP

Genetic Association Database (GAD)
FN3KRP
genes like me logo Genes that share disorders with FN3KRP: view

No data available for UniProtKB/Swiss-Prot for FN3KRP Gene

Publications for FN3KRP Gene

  1. A mammalian protein homologous to fructosamine-3-kinase is a ketosamine-3-kinase acting on psicosamines and ribulosamines but not on fructosamines. (PMID: 14633848) Collard F. … Van Schaftingen E. (Diabetes 2003) 2 3 4 23
  2. Fructosamine 3-kinase-related protein and deglycation in human erythrocytes. (PMID: 15137908) Collard F. … Van Schaftingen E. (Biochem. J. 2004) 3 4 23
  3. Fructosamine-6-phosphates are deglycated by phosphorylation to fructosamine-3,6-bisphosphates catalyzed by fructosamine-3-kinase (FN3K) and/or fructosamine-3-kinase-related-protein (FN3KRP). (PMID: 16920277) Szwergold B.S. (Med. Hypotheses 2007) 3 23
  4. Fructosamine-3-kinase-related-protein phosphorylates glucitolamines on the C-4 hydroxyl: novel substrate specificity of an enigmatic enzyme. (PMID: 17686456) Szwergold B. … Loomes K. (Biochem. Biophys. Res. Commun. 2007) 3 23
  5. Mapping of the ATP-binding domain of human fructosamine 3-kinase-related protein by affinity labelling with 5'-[p-(fluorosulfonyl)benzoyl]adenosine. (PMID: 18637789) Payne L.S. … Loomes K.M. (Biochem. J. 2008) 3 23

Products for FN3KRP Gene

Sources for FN3KRP Gene

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