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Aliases for FN3KRP Gene

Aliases for FN3KRP Gene

  • Fructosamine 3 Kinase Related Protein 2 3 5
  • Fructosamine-3-Kinase-Related Protein 3 4
  • FN3K-Related Protein 3 4
  • FN3K-RP 3 4
  • Testis Secretory Sperm-Binding Protein Li 211a 3
  • EC 2.7.1.- 4
  • FN3KL 3

External Ids for FN3KRP Gene

Previous GeneCards Identifiers for FN3KRP Gene

  • GC17P081353
  • GC17P078267
  • GC17P080674
  • GC17P076074

Summaries for FN3KRP Gene

Entrez Gene Summary for FN3KRP Gene

  • A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

GeneCards Summary for FN3KRP Gene

FN3KRP (Fructosamine 3 Kinase Related Protein) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Gamma carboxylation, hypusine formation and arylsulfatase activation. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and kinase activity. An important paralog of this gene is FN3K.

UniProtKB/Swiss-Prot for FN3KRP Gene

  • Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein-bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation.

Gene Wiki entry for FN3KRP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FN3KRP Gene

Genomics for FN3KRP Gene

Regulatory Elements for FN3KRP Gene

Promoters for FN3KRP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FN3KRP on UCSC Golden Path with GeneCards custom track

Genomic Location for FN3KRP Gene

Chromosome:
17
Start:
82,716,683 bp from pter
End:
82,730,328 bp from pter
Size:
13,646 bases
Orientation:
Plus strand

Genomic View for FN3KRP Gene

Genes around FN3KRP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FN3KRP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FN3KRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FN3KRP Gene

Proteins for FN3KRP Gene

  • Protein details for FN3KRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HA64-KT3K_HUMAN
    Recommended name:
    Ketosamine-3-kinase
    Protein Accession:
    Q9HA64
    Secondary Accessions:
    • Q969F4
    • Q9H0U7

    Protein attributes for FN3KRP Gene

    Size:
    309 amino acids
    Molecular mass:
    34412 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB66566.1; Type=Erroneous termination; Positions=198; Note=Translated as Leu.; Evidence={ECO:0000305};

neXtProt entry for FN3KRP Gene

Proteomics data for FN3KRP Gene at MOPED

Post-translational modifications for FN3KRP Gene

  • Ubiquitination at Lys 45
  • Modification sites at PhosphoSitePlus

Other Protein References for FN3KRP Gene

Antibody Products

No data available for DME Specific Peptides for FN3KRP Gene

Domains & Families for FN3KRP Gene

Suggested Antigen Peptide Sequences for FN3KRP Gene

Graphical View of Domain Structure for InterPro Entry

Q9HA64

UniProtKB/Swiss-Prot:

KT3K_HUMAN :
  • Belongs to the fructosamine kinase family.
Family:
  • Belongs to the fructosamine kinase family.
genes like me logo Genes that share domains with FN3KRP: view

No data available for Gene Families for FN3KRP Gene

Function for FN3KRP Gene

Molecular function for FN3KRP Gene

UniProtKB/Swiss-Prot Function:
Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein-bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation.

Enzyme Numbers (IUBMB) for FN3KRP Gene

genes like me logo Genes that share phenotypes with FN3KRP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FN3KRP

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FN3KRP Gene

Localization for FN3KRP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FN3KRP Gene COMPARTMENTS Subcellular localization image for FN3KRP gene
Compartment Confidence
cytosol 5
nucleus 3
chloroplast 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FN3KRP Gene

Pathways & Interactions for FN3KRP Gene

genes like me logo Genes that share pathways with FN3KRP: view

Interacting Proteins for FN3KRP Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000269373%0d%0a9606.ENSP00000285199%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000384109%0d%0a
Selected Interacting proteins: ENSP00000269373 Q9HA64-KT3K_HUMAN for FN3KRP Gene via STRING I2D

Gene Ontology (GO) - Biological Process for FN3KRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FN3KRP: view

No data available for SIGNOR curated interactions for FN3KRP Gene

Drugs & Compounds for FN3KRP Gene

(1) Drugs for FN3KRP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for FN3KRP Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fructosamine
  • 1-Amino-1-deoxy-D-fructose
  • D-Isoglucosamine
4429-04-3
genes like me logo Genes that share compounds with FN3KRP: view

Transcripts for FN3KRP Gene

Unigene Clusters for FN3KRP Gene

Fructosamine 3 kinase related protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FN3KRP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2:
SP3: - - -

Relevant External Links for FN3KRP Gene

GeneLoc Exon Structure for
FN3KRP
ECgene alternative splicing isoforms for
FN3KRP

Expression for FN3KRP Gene

mRNA expression in normal human tissues for FN3KRP Gene

Protein differential expression in normal tissues from HIPED for FN3KRP Gene

This gene is overexpressed in Uterus (8.6) and Lymph node (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FN3KRP Gene



SOURCE GeneReport for Unigene cluster for FN3KRP Gene Hs.31431

mRNA Expression by UniProt/SwissProt for FN3KRP Gene

Q9HA64-KT3K_HUMAN
Tissue specificity: Expressed in erythrocytes.
genes like me logo Genes that share expression patterns with FN3KRP: view

Protein tissue co-expression partners for FN3KRP Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FN3KRP Gene

Orthologs for FN3KRP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FN3KRP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FN3KRP 36
  • 99 (a)
OneToOne
FN3KRP 35
  • 99.14 (n)
  • 98.71 (a)
cow
(Bos Taurus)
Mammalia FN3KRP 35
  • 86.58 (n)
  • 87.01 (a)
FN3KRP 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FN3KRP 36
  • 84 (a)
OneToOne
FN3KRP 35
  • 85.54 (n)
  • 86.73 (a)
mouse
(Mus musculus)
Mammalia Fn3krp 16
Fn3krp 36
  • 89 (a)
OneToOne
Fn3krp 35
  • 85.33 (n)
  • 89 (a)
oppossum
(Monodelphis domestica)
Mammalia FN3KRP 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FN3KRP 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fn3krp 35
  • 84.47 (n)
  • 88.35 (a)
chicken
(Gallus gallus)
Aves FN3KRP 35
  • 72.92 (n)
  • 78.96 (a)
FN3KRP 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FN3KRP 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fn3krp 35
  • 69.26 (n)
  • 69.26 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11207 35
zebrafish
(Danio rerio)
Actinopterygii fn3krp 36
  • 70 (a)
OneToMany
fn3krp 35
  • 66.56 (n)
  • 70.82 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y116A8C.25 35
  • 45.83 (n)
  • 39.34 (a)
Y116A8C.25 36
  • 33 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G61080 35
  • 48.36 (n)
  • 41.9 (a)
rice
(Oryza sativa)
Liliopsida Os03g0117800 35
  • 50 (n)
  • 42.28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToMany
Species with no ortholog for FN3KRP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FN3KRP Gene

ENSEMBL:
Gene Tree for FN3KRP (if available)
TreeFam:
Gene Tree for FN3KRP (if available)

Paralogs for FN3KRP Gene

Paralogs for FN3KRP Gene

(1) SIMAP similar genes for FN3KRP Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with FN3KRP: view

Variants for FN3KRP Gene

Sequence variations from dbSNP and Humsavar for FN3KRP Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs3748811 - 82,718,934(+) GATGG(C/T)AAGTT nc-transcript-variant, reference, missense
rs2246103 -- 82,726,762(+) GGCGG(C/T)GGGGA intron-variant
rs2246226 -- 82,725,883(+) GAAAG(C/T)GGGAG intron-variant
rs2246558 -- 82,723,299(-) TCCTC(C/T)CGAGG intron-variant
rs2379357 -- 82,723,664(+) GTGTG(C/T)GCGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FN3KRP Gene

Variant ID Type Subtype PubMed ID
nsv428351 CNV Gain 18775914
esv21913 CNV Gain+Loss 19812545
nsv909240 CNV Loss 21882294
dgv3363n71 CNV Loss 21882294
nsv909243 CNV Loss 21882294
nsv833575 CNV Loss 17160897
nsv909244 CNV Loss 21882294
esv2716524 CNV Deletion 23290073

Variation tolerance for FN3KRP Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.68; 57.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FN3KRP Gene

HapMap Linkage Disequilibrium report
FN3KRP
Human Gene Mutation Database (HGMD)
FN3KRP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FN3KRP Gene

Disorders for FN3KRP Gene

Relevant External Links for FN3KRP

Genetic Association Database (GAD)
FN3KRP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FN3KRP

No disorders were found for FN3KRP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FN3KRP Gene

Publications for FN3KRP Gene

  1. A mammalian protein homologous to fructosamine-3-kinase is a ketosamine-3-kinase acting on psicosamines and ribulosamines but not on fructosamines. (PMID: 14633848) Collard F. … Van Schaftingen E. (Diabetes 2003) 2 3 4 23 67
  2. Mapping of the ATP-binding domain of human fructosamine 3-kinase-related protein by affinity labelling with 5'-[p-(fluorosulfonyl)benzoyl]adenosine. (PMID: 18637789) Payne L.S. … Loomes K.M. (Biochem. J. 2008) 3 23
  3. Fructosamine-6-phosphates are deglycated by phosphorylation to fructosamine-3,6-bisphosphates catalyzed by fructosamine-3-kinase (FN3K) and/or fructosamine-3-kinase-related-protein (FN3KRP). (PMID: 16920277) Szwergold B.S. (Med. Hypotheses 2007) 3 23
  4. Fructosamine-3-kinase-related-protein phosphorylates glucitolamines on the C-4 hydroxyl: novel substrate specificity of an enigmatic enzyme. (PMID: 17686456) Szwergold B. … Loomes K. (Biochem. Biophys. Res. Commun. 2007) 3 23
  5. Some clues as to the regulation, expression, function, and distribution of fructosamine-3-kinase and fructosamine-3-kinase-related protein. (PMID: 16037310) Conner J.R. … Szwergold B.S. (Ann. N. Y. Acad. Sci. 2005) 3 23

Products for FN3KRP Gene

Sources for FN3KRP Gene

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