FN3KRP Gene
protein-coding GIFtS: 51
GCID: GC17P080674
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|
fructosamine 3 kinase related protein
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Aliases
for FN3KRP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fructosamine 3 Kinase Related Protein1 2 | | FN3K-Related Protein2 3 | | FN3KL1 2 | | FLJ121711 | | Fructosamine-3-Kinase-Related Protein2 3 | | Ketosamine-3-Kinase1 | | FN3K-RP2 3 | | EC 2.7.1.-3 |
Export aliases for FN3KRP gene to outside databasesPrevious GC identifers: GC17P081353 GC17P078267 GC17P076074 |
Summaries
for FN3KRP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FN3KRP:
A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysineresidues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme whichcatalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes ahighly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymesmay result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcriptvariants. (provided by RefSeq, Mar 2012)
UniProtKB/Swiss-Prot: KT3K_HUMAN, Q9HA64Function: Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugarmoiety. Protein-bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose underphysiological conditions. Thus phosphorylation leads to deglycation
Gene Wiki entry for FN3KRP
|
Genomic Views
for FN3KRP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010663.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FN3KRP gene promoter:
Sp1 Olf-1 CBF-C PPAR-gamma1 CBF-A CBF-B CP1C CP1A PPAR-gamma2 CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for FN3KRP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FN3KRP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25FN3KRP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P080674: view genomic region
(about GC identifiers)
Start:
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80,674,559 bp from pter |
End:
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80,688,204 bp from pter |
Size:
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13,646 bases |
Orientation:
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plus strand |
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Proteins
for FN3KRP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KT3K_HUMAN, Q9HA64 (See
protein sequence)Recommended Name: Ketosamine-3-kinase Size: 309 amino acids; 34412 Da
Sequence caution: Sequence=CAB66566.1; Type=Erroneous termination; Positions=198; Note=Translated as Leu;
Secondary accessions: Q969F4 Q9H0U7Explore the universe of human proteins at neXtProt for FN3KRP: NX_Q9HA64
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HA64
FN3KRP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_078895.2
ENSEMBL proteins: ENSP00000269373 ENSP00000458869 ENSP00000460869 ENSP00000458550 ENSP00000460777 ENSP00000459653 ENSP00000460243 ENSP00000459751 ENSP00000444994
Human Recombinant Protein Products:
FN3KRP Antibody Products:
Assay Products for FN3KRP: |
Protein
Domains /
Families
for FN3KRP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FN3KRP for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9HA64ProtoNet protein and cluster: Q9HA64 2 Blocks protein families: IPB002575 Aminoglycoside phosphotransferase IPB005581 Fructosamine kinase
UniProtKB/Swiss-Prot: KT3K_HUMAN, Q9HA64Similarity: Belongs to the fructosamine kinase family |
Function
for FN3KRP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KT3K_HUMAN, Q9HA64Function: Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugarmoiety. Protein-bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose underphysiological conditions. Thus phosphorylation leads to deglycationEnzyme Number (IUBMB): EC 2.7.1.-1
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FN3KRP
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FN3KRP |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016301 | kinase activity |
IEA | -- | | GO:0016772 | transferase activity, transferring phosphorus-containing groups |
-- | -- |
FN3KRP for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for FN3KRP:
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Pathways & Interactions
for FN3KRP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FN3KRP
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/6 Interacting proteins for FN3KRP (Q9HA643 ENSP000002693734) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
|
Drugs & Compounds
for FN3KRP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
FN3KRP for compounds About GeneDecksing
 Browse Tocris compounds for FN3KRP
1 HMDB Compound for FN3KRP About this table
5 Novoseek chemical compound relationships for FN3KRP gene About this table
Search CenterWatch for drugs/clinical trials and news about FN3KRP / KT3K
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Transcripts
for FN3KRP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FN3KRP gene: NM_024619.3 Unigene Cluster for FN3KRP: Fructosamine 3 kinase related protein Hs.31431 [show with all ESTs]Unigene Representative Sequence: NR_04640811 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000269373(uc002kfu.3 uc010wvr.2) ENST00000575052 ENST00000574832
ENST00000574356 ENST00000574206 ENST00000577128 ENST00000573158 ENST00000571482
ENST00000576363 ENST00000571594 ENST00000535965
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FN3KRP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FN3KRP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FN3KRP (NM_024619) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FN3KRP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FN3KRP |
Additional cDNA sequence: AK022233.1 AK293523.1 AK301958.1 AK315373.1 AL136631.1 AY360465.1 BC001458.2 BC007611.1 BC014408.1 CR533461.1 NR_046408.1 9 DOTS entries: DT.214775 DT.100781256 DT.86852556 DT.91796926 DT.100781251 DT.101980368 DT.120900187 DT.95299659 DT.95299671 24/236 AceView cDNA sequences (see all 236): CR590236 CR592111 CR615772 CR618775 CR601595 BM746475 AA300642 BQ962918 BM055135 AI363888 CR608301 BQ924250 BQ436144 CR590234 CR590420 BQ936506 CR617786 BU632679 AK022233 AA282248 BF435556 BI822749 AI815663 BP368586
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for FN3KRP About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b |
|---|
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| SP1: | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for FN3KRP
|
Expression
for FN3KRP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FN3KRP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGGCATTG
About this image
See FN3KRP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FN3KRP
SOURCE GeneReport for Unigene cluster: Hs.31431
UniProtKB/Swiss-Prot: KT3K_HUMAN, Q9HA64Tissue specificity: Expressed in erythrocytes
SABiosciences Custom PCR Arrays for FN3KRP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FN3KRP
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FN3KRP |
Orthologs
for FN3KRP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for FN3KRP gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for FN3KRP (if available)
TreeFam Gene Tree for FN3KRP (if available) |
Paralogs
for FN3KRP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FN3KRP gene
- FN3K2
1 SIMAP similar gene for FN3KRP using alignment to 10 protein entries: KT3K_HUMAN (see all proteins):FN3K
FN3KRP for paralogs About GeneDecksing
|
Genomic Variants
for FN3KRP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FN3KRP (80674559 - 80688204 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FN3KRP
1 CNV: 73078 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FN3KRP |
|
Disorders
/ Diseases
for FN3KRP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 FN3KRP for disorders About MalaCards
FN3KRP for disorders About GeneDecksing
OMIM gene information: 611683
OMIM disorders: --
Export disorders for FN3KRP gene to outside databases
|
Publications
for FN3KRP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FN3KRP gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with FN3KRP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A mammalian protein homologous to fructosamine-3-kinase is a ketosamine-3-kinase acting on psicosamines and ribulosamines but not on fructosamines. (PubMed id 14633848)1, 2, 3, 9 Collard F....Van Schaftingen E. (2003)
- Fructosamine 3-kinase-related protein and deglycation in human erythrocytes. (PubMed id 15137908)1, 2, 9 Collard F.... Van Schaftingen E. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Some clues as to the regulation, expression, function, and distribution of fructosamine-3-kinase and fructosamine-3-kinase-related protein. (PubMed id 16037310)1, 9 Conner J.R....Szwergold B.S. (2005)
- Mapping of the ATP-binding domain of human fructosamine 3-kinase-related protein by affinity labelling with 5'-[p-(fluorosulfonyl)benzoyl]adenosine. (PubMed id 18637789)1, 9 Payne L.S....Loomes K.M. (2008)
- The expression of the genes for fructosamine-3-kinase and fructosamine-3-kinase-related protein appears to be constitutive and unaffected by environmental signals. (PubMed id 15381090)1, 9 Conner J.R....Szwergold B.S. (2004)
- Fructosamine-3-kinase-related-protein phosphorylates glucitolamines on the C-4 hydroxyl: novel substrate specificity of an enigmatic enzyme. (PubMed id 17686456)1, 9 Szwergold B....Loomes K. (2007)
- Fructosamine-6-phosphates are deglycated by phosphorylation to fructosamine-3,6-bisphosphates catalyzed by fructosamine-3-kinase (FN3K) and/or fructosamine-3-kinase-related-protein (FN3KRP). (PubMed id 16920277)1, 9 Szwergold B.S. (2007)
|
External Searches for FN3KRP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FN3KRP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FN3KRP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FN3KRP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FN3KRP | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FN3KRP gene:
Search GeneIP for patents involving FN3KRP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FN3KRP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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