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Aliases for FN3K Gene

Aliases for FN3K Gene

  • Fructosamine 3 Kinase 2 3 5
  • Fructosamine-3-Kinase 3
  • EC 2.7.1.- 4

External Ids for FN3K Gene

Previous GeneCards Identifiers for FN3K Gene

  • GC17P079820
  • GC17P083669
  • GC17P081223
  • GC17P081372
  • GC17P078286
  • GC17P080693
  • GC17P076093

Summaries for FN3K Gene

Entrez Gene Summary for FN3K Gene

  • A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way, fructosamines, are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of fructosamines which may result in deglycation. [provided by RefSeq, Feb 2012]

GeneCards Summary for FN3K Gene

FN3K (Fructosamine 3 Kinase) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Gamma carboxylation, hypusine formation and arylsulfatase activation. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and fructosamine-3-kinase activity. An important paralog of this gene is FN3KRP.

UniProtKB/Swiss-Prot for FN3K Gene

  • May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a role in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), fructoselysine, fructoseglycine, fructose and glycated lysozyme.

Gene Wiki entry for FN3K Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FN3K Gene

Genomics for FN3K Gene

Regulatory Elements for FN3K Gene

Enhancers for FN3K Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FN3K on UCSC Golden Path with GeneCards custom track

Promoters for FN3K Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FN3K on UCSC Golden Path with GeneCards custom track

Genomic Location for FN3K Gene

Chromosome:
17
Start:
82,735,575 bp from pter
End:
82,751,197 bp from pter
Size:
15,623 bases
Orientation:
Plus strand

Genomic View for FN3K Gene

Genes around FN3K on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FN3K Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FN3K Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FN3K Gene

Proteins for FN3K Gene

  • Protein details for FN3K Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H479-FN3K_HUMAN
    Recommended name:
    Fructosamine-3-kinase
    Protein Accession:
    Q9H479

    Protein attributes for FN3K Gene

    Size:
    309 amino acids
    Molecular mass:
    35171 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for FN3K Gene

Post-translational modifications for FN3K Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FN3K Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for FN3K

No data available for DME Specific Peptides for FN3K Gene

Domains & Families for FN3K Gene

Graphical View of Domain Structure for InterPro Entry

Q9H479

UniProtKB/Swiss-Prot:

FN3K_HUMAN :
  • Belongs to the fructosamine kinase family.
Family:
  • Belongs to the fructosamine kinase family.
genes like me logo Genes that share domains with FN3K: view

No data available for Gene Families for FN3K Gene

Function for FN3K Gene

Molecular function for FN3K Gene

UniProtKB/Swiss-Prot Function:
May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a role in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), fructoselysine, fructoseglycine, fructose and glycated lysozyme.

Enzyme Numbers (IUBMB) for FN3K Gene

Gene Ontology (GO) - Molecular Function for FN3K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016301 kinase activity TAS --
GO:0030387 fructosamine-3-kinase activity IEA,NAS 11016445
genes like me logo Genes that share ontologies with FN3K: view
genes like me logo Genes that share phenotypes with FN3K: view

Animal Models for FN3K Gene

MGI Knock Outs for FN3K:

Animal Model Products

  • Taconic Biosciences Mouse Models for FN3K

CRISPR Products

miRNA for FN3K Gene

miRTarBase miRNAs that target FN3K

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FN3K

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FN3K Gene

Localization for FN3K Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FN3K Gene COMPARTMENTS Subcellular localization image for FN3K gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FN3K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FN3K: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FN3K Gene

Pathways & Interactions for FN3K Gene

genes like me logo Genes that share pathways with FN3K: view

Interacting Proteins for FN3K Gene

Selected Interacting proteins: Q9H479-FN3K_HUMAN for FN3K Gene via IID

Gene Ontology (GO) - Biological Process for FN3K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016310 phosphorylation IEA --
GO:0030389 fructosamine metabolic process IEA,IBA --
GO:0030393 fructoselysine metabolic process NAS 11016445
GO:0030855 epithelial cell differentiation IEP 21492153
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FN3K: view

No data available for SIGNOR curated interactions for FN3K Gene

Drugs & Compounds for FN3K Gene

(4) Drugs for FN3K Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for FN3K Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fructosamine
  • 1-Amino-1-deoxy-D-fructose
  • D-Isoglucosamine
4429-04-3
genes like me logo Genes that share compounds with FN3K: view

Transcripts for FN3K Gene

Unigene Clusters for FN3K Gene

Fructosamine 3 kinase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FN3K

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FN3K Gene

No ASD Table

Relevant External Links for FN3K Gene

GeneLoc Exon Structure for
FN3K
ECgene alternative splicing isoforms for
FN3K

Expression for FN3K Gene

mRNA expression in normal human tissues for FN3K Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FN3K Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.1), Fetal gut (7.3), and Platelet (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FN3K Gene



Protein tissue co-expression partners for FN3K Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FN3K Gene:

FN3K

SOURCE GeneReport for Unigene cluster for FN3K Gene:

Hs.151135

mRNA Expression by UniProt/SwissProt for FN3K Gene:

Q9H479-FN3K_HUMAN
Tissue specificity: Expressed in erythrocytes.
genes like me logo Genes that share expression patterns with FN3K: view

Primer Products

No data available for mRNA differential expression in normal tissues for FN3K Gene

Orthologs for FN3K Gene

This gene was present in the common ancestor of animals.

Orthologs for FN3K Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FN3K 34
  • 88.13 (n)
  • 90.94 (a)
FN3K 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FN3K 34
  • 83.69 (n)
  • 85.46 (a)
FN3K 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fn3k 34
  • 84.03 (n)
  • 88.67 (a)
Fn3k 16
Fn3k 35
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FN3K 34
  • 99.57 (n)
  • 99.35 (a)
FN3K 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FN3K 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves FN3K 34
  • 68.82 (n)
  • 73.14 (a)
FN3K 35
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FN3K 35
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fn3krp 35
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y116A8C.25 36
  • 35 (a)
Y116A8C.25 35
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToMany
Species where no ortholog for FN3K was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FN3K Gene

ENSEMBL:
Gene Tree for FN3K (if available)
TreeFam:
Gene Tree for FN3K (if available)

Paralogs for FN3K Gene

Paralogs for FN3K Gene

(1) SIMAP similar genes for FN3K Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FN3K Gene

genes like me logo Genes that share paralogs with FN3K: view

Variants for FN3K Gene

Sequence variations from dbSNP and Humsavar for FN3K Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2243416 -- 82,749,052(-) TTTTA(C/T)AGATG intron-variant
rs2249113 -- 82,748,338(-) gaaac(G/T)ccatc intron-variant
rs2249116 -- 82,748,239(+) tgcct(C/G)tgggt intron-variant
rs2251989 -- 82,747,694(-) aggcc(A/G)ggcct intron-variant
rs2252766 -- 82,741,851(+) cattc(A/G)tgatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FN3K Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv2762577 CNV gain+loss 21179565
nsv1061637 CNV loss 25217958
nsv1067553 CNV loss 25217958
nsv1072765 CNV deletion 25765185
nsv428351 CNV gain 18775914
nsv833575 CNV loss 17160897
nsv952395 CNV deletion 24416366
nsv952396 CNV deletion 24416366
nsv978469 CNV duplication 23825009

Variation tolerance for FN3K Gene

Residual Variation Intolerance Score: 35.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.57; 77.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FN3K Gene

Human Gene Mutation Database (HGMD)
FN3K
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FN3K

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FN3K Gene

Disorders for FN3K Gene

Relevant External Links for FN3K

Genetic Association Database (GAD)
FN3K
Human Genome Epidemiology (HuGE) Navigator
FN3K
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FN3K

No disorders were found for FN3K Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FN3K Gene

Publications for FN3K Gene

  1. A polymorphism within the fructosamine-3-kinase gene is associated with HbA1c Levels and the onset of type 2 diabetes mellitus. (PMID: 19834870) MohA!s M. … Wittmann I. (Exp. Clin. Endocrinol. Diabetes 2010) 3 22 46 65
  2. Fructosamine 3-kinase, an enzyme involved in protein deglycation. (PMID: 14641062) Delpierre G. … Van Schaftingen E. (Biochem. Soc. Trans. 2003) 2 3 22 65
  3. Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo. (PMID: 11522682) Szwergold B.S. … Beisswenger P.J. (Diabetes 2001) 2 3 22 65
  4. Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase. (PMID: 11016445) Delpierre G. … Van Schaftingen E. (Diabetes 2000) 3 4 22 65
  5. Fructosamine-6-phosphates are deglycated by phosphorylation to fructosamine-3,6-bisphosphates catalyzed by fructosamine-3-kinase (FN3K) and/or fructosamine-3-kinase-related-protein (FN3KRP). (PMID: 16920277) Szwergold B.S. (Med. Hypotheses 2007) 3 22 65

Products for FN3K Gene

  • Cloud-Clone Corp. Antibodies for FN3K
  • Cloud-Clone Corp. Proteins for FN3K
  • Cloud-Clone Corp Assay Kits for FN3K

Sources for FN3K Gene

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