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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FN3K Gene

protein-coding   GIFtS: 50
GCID: GC17P080693

fructosamine 3 kinase

 Explore 4 diseases affiliated with
FN3K via our new
 Human Malady Compendium 
Biological research products
for FN3K
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Fructosamine 3 Kinase1 2
Fructosamine-3-Kinase1
EC 2.7.1.-3

External Ids:    HGNC: 248221   Entrez Gene: 641222   Ensembl: ENSG000001673637   OMIM: 6084255   UniProtKB: Q9H4793   

Export aliases for FN3K gene to outside databases

Previous GC identifers: GC17P079820 GC17P083669 GC17P081223 GC17P081372 GC17P078286 GC17P076093


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FN3K:
A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine
residues (glycation). Proteins modified in this way, fructosamines, are less active or functional. This gene encodes
an enzyme which catalyzes the phosphorylation of fructosamines which may result in deglycation. (provided by RefSeq,
Feb 2012)

UniProtKB/Swiss-Prot: FN3K_HUMAN, Q9H479
Function: May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a role
in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), fructoselysine, fructoseglycine, fructose and glycated
lysozyme

Gene Wiki entry for FN3K


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010663.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FN3K gene promoter:
         SRF   Tal-1   Sp1   SRF (504 AA)   MyoD   Olf-1   E47   PPAR-alpha   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFN3K promoter sequence
   Search SABiosciences Chromatin IP Primers for FN3K

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FN3K


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25

FN3K Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FN3K gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P080693:  view genomic region     (about GC identifiers)

Start:
80,693,451 bp from pter      End:
80,709,073 bp from pter
Size:
15,623 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FN3K_HUMAN, Q9H479 (See protein sequence)
Recommended Name: Fructosamine-3-kinase  
Size: 309 amino acids; 35171 Da
Subunit: Monomer (Probable)

Explore the universe of human proteins at neXtProt for FN3K: NX_Q9H479

FN3K Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_071441.1  
ENSEMBL proteins: 
 ENSP00000300784  

Human Recombinant Protein Products: 
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Uscn Proteins for FN3K

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--


FN3K for ontologies           About GeneDecksing



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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FN3K for domains           About GeneDecksing

2 InterPro domains/families:
 IPR011009 Kinase-like_dom
 IPR016477 Fructo-/Ketosamine-3-kinase

Graphical View of Domain Structure for InterPro Entry Q9H479

ProtoNet protein and cluster: Q9H479

2 Blocks protein families:
IPB002575 Aminoglycoside phosphotransferase
IPB005581 Fructosamine kinase


UniProtKB/Swiss-Prot: FN3K_HUMAN, Q9H479
Similarity: Belongs to the fructosamine kinase family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: FN3K_HUMAN, Q9H479
Function: May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a role
in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), fructoselysine, fructoseglycine, fructose and glycated
lysozyme

Enzyme Number (IUBMB): EC 2.7.1.-1

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0030387fructosamine-3-kinase activity NAS11016445


FN3K for ontologies           About GeneDecksing


1 GenomeRNAi human phenotype for FN3K:
 Increased apoptosis 

Animal Models:
     Mouse knock-out Fn3ktm1Mvdc for FN3K
     3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fn3k):
 cellular  homeostasis/metabolism  renal/urinary system 

FN3K for phenotypes           About GeneDecksing


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FN3K

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0030389fructosamine metabolic process ----
GO:0030393fructoselysine metabolic process NAS11016445


FN3K for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FN3K for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FN3K

1 HMDB Compound for FN3K    About this table
CompoundSynonyms CAS #PubMed Ids
Fructosamine1-Amino-1-deoxy-D-fructose (see all 2)4429-04-3--
7 Novoseek chemical compound relationships for FN3K gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
1-deoxy-1-morpholinofructose 98 11 15102834 (3), 15137908 (2), 14633848 (1)
fructosamine 87.6 30 14641062 (4), 15102834 (3), 15366734 (3), 16523184 (2) (see all 11)
lysine 47.4 5 15102834 (1), 11522682 (1), 17072594 (1)
glucose 44.8 15 15102834 (3), 16037310 (1), 14641081 (1), 14633848 (1) (see all 9)
glucose 6-phosphate 36 3 16670083 (3)
carbon 29.9 4 15366734 (1), 14641062 (1), 15137908 (1)
atp 12.7 3 15102834 (2)

Search CenterWatch for drugs/clinical trials and news about FN3K 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FN3K gene: 
NM_022158.3  

Unigene Cluster for FN3K:

Fructosamine 3 kinase
Hs.151135  [show with all ESTs]
Unigene Representative Sequence: AK054838
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000300784(uc010wvs.1) ENST00000574496 ENST00000573841 ENST00000572813
ENST00000570734(uc002kfw.1)

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Inhib. RNA
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Additional cDNA sequence: 

AJ404615.1 AK054838.1 AK294871.1 BC042680.1 

7 DOTS entries:

DT.426795  DT.95196052  DT.95341716  DT.120952214  DT.92334603  DT.40265547  DT.98084000 

24/58 AceView cDNA sequences (see all 58):

AA444040 CR625457 BQ188161 AK054838 BM715417 BU849250 BF876456 BU726179 
BQ648843 AJ404615 NM_022158 BU844827 BM817659 BU191500 BI754772 BM766754 
BF874303 BF876028 BM665193 BE159018 BQ685781 BQ185329 AA444010 BF874822 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FN3K expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGAAGGCTGC

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See FN3K Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FN3K

SOURCE GeneReport for Unigene cluster: Hs.151135

UniProtKB/Swiss-Prot: FN3K_HUMAN, Q9H479
Tissue specificity: Expressed in erythrocytes

    SABiosciences Custom PCR Arrays for FN3K
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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FN3K

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for FN3K gene from 8/19 species (see all 19)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fn3k1 , 5 fructosamine 3 kinase1, 5 84.03(n)1
88.67(a)1
  11 (85.38 cM)5
638281  NM_022014.41  NP_071297.11 
 1214349135 
chicken
(Gallus gallus)
Aves FN3K1 fructosamine 3 kinase 68.82(n)
73.14(a)
  417335  XM_415601.3  XP_415601.1 
lizard
(Anolis carolinensis)
Reptilia FN3K6
--
71(a)
1 ↔ 1
2(108419676-108434312)
zebrafish
(Danio rerio)
Actinopterygii fn3krp6
fructosamine-3-kinase-related protein
62(a)
1 → many
3(49381530-49390141)
worm
(Caenorhabditis elegans)
Secernentea Y116A8C.253   -- 35(a)   IV(17074731-17078902)   --
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G610806
protein kinase-like protein
33(a)
1 → many
3(22607130-22609099)
rice
(Oryza sativa)
Liliopsida --
methylthioribose kinase, putative, expressed
30(a)
1 → many
3(973602-977413)
E. coli
(Escherichia coli)
Gamma proteobacteria yniA6
predicted phosphotransferase/kinase
29(a)
1 → many
Chromosome(1805820-1806680)


ENSEMBL Gene Tree for FN3K (if available)
TreeFam Gene Tree for FN3K (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for FN3K gene
FN3KRP2  
1 SIMAP similar gene for FN3K using alignment to 1 protein entry:     FN3K_HUMAN:
FN3KRP

FN3K for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for FN3K
PGOHUM00000263067 PGOHUM00000246545


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/317 NCBI SNPs in FN3K are shown (see all 317    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1811510421,2
--80691474(+) AACTGA/GAGCTG 1 -- us2k10--------
rs348848451,2
C,F,--80691536(+) ATACCC/AAGCCA 1 -- us2k15Minor allele frequency- A:0.10NA 128
rs80818911,2
C,A,--80691741(+) tgtcaA/Cgaggt 1 -- us2k15Minor allele frequency- C:0.19CSA WA NA EA 361
rs1406836241,2
--80691800(+) AGGCAC/GGCGGA 1 -- us2k10--------
rs1504546611,2
--80691801(+) GGCAGG/TCGGAT 1 -- us2k10--------
rs1136995271,2
C,--80691802(+) GCAGGC/TGGATC 1 -- us2k11Minor allele frequency- T:0.50WA 2
rs1496295061,2
--80691883(+) ATTAGC/TGGGGC 1 -- us2k10--------
rs1442419761,2
--80691896(+) GGTGAC/TGCGTG 1 -- us2k10--------
rs1390062231,2
--80691897(+) GTGACA/GCGTGC 1 -- us2k10--------
rs1859928881,2
--80691952(+) GAACCC/TGGGAG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for FN3K (80693451 - 80709073 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FN3K
     1 CNV: 73078
Human Gene Mutation Database (HGMD): FN3K

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FN3K for disorders           About GeneDecksing

OMIM gene information: 608425    OMIM disorders: --

4 diseases for FN3K:    About MalaCards
type 2 diabetes mellitus    diabetes mellitus    hyperglycemia    colorectal cancer

1 Novoseek disease relationship for FN3K gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
hyperglycemia 39.4 2 15694695 (1), 16523184 (1)

Human Genome Epidemiology (HuGE) Navigator: FN3K (3 documents)

Export disorders for FN3K gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for FN3K gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with FN3K)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo. (PubMed id 11522682)1, 3, 9 Szwergold B.S....Beisswenger P.J. (2001)
  2. Fructosamine 3-kinase, an enzyme involved in protein deglycation. (PubMed id 14641062)1, 3, 9 Delpierre G. and Van Schaftingen E. (2003)
  3. Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase. (PubMed id 11016445)1, 2, 9 Delpierre G.... Van Schaftingen E. (2000)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. Variability in erythrocyte fructosamine 3-kinase activity in humans correlates with polymorphisms in the FN3K gene and impacts on haemoglobin glycation at specific sites. (PubMed id 16523184)1, 9 Delpierre G....Van Schaftingen E. (2006)
  6. Some clues as to the regulation, expression, function, and distribution of fructosamine-3-kinase and fructosamine-3-kinase-related protein. (PubMed id 16037310)1, 9 Conner J.R....Szwergold B.S. (2005)
  7. Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein. (PubMed id 15331600)1, 9 Delplanque J....Van Schaftingen E. (2004)
  8. Identification of fructosamine residues deglycated by fructosamine-3-kinase in human hemoglobin. (PubMed id 15102834)1, 9 Delpierrre G....Van Schaftingen E. (2004)
  9. The expression of the genes for fructosamine-3-kinase and fructosamine-3-kinase-related protein appears to be constitutive and unaffected by environmental signals. (PubMed id 15381090)1, 9 Conner J.R....Szwergold B.S. (2004)
  10. Fructosamine-6-phosphates are deglycated by phosphorylation to fructosamine-3,6-bisphosphates catalyzed by fructosamine-3-kinase (FN3K) and/or fructosamine-3-kinase-related-protein (FN3KRP). (PubMed id 16920277)1, 9 Szwergold B.S. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 64122 HGNC: 24822 AceView: FN3K Ensembl:ENSG00000167363 euGenes: HUgn64122
ECgene: FN3K H-InvDB: FN3K

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FN3K Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FN3K gene:
Search GeneIP for patents involving FN3K

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FN3K
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FN3K
       
GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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VWF
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von Willebrand factor
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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