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Aliases for FN3K Gene

Aliases for FN3K Gene

  • Fructosamine 3 Kinase 2 3
  • Fructosamine-3-Kinase 3
  • EC 2.7.1.- 4

External Ids for FN3K Gene

Summaries for FN3K Gene

Entrez Gene Summary for FN3K Gene

  • A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way, fructosamines, are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of fructosamines which may result in deglycation. [provided by RefSeq, Feb 2012]

GeneCards Summary for FN3K Gene

FN3K (Fructosamine 3 Kinase) is a Protein Coding gene. Diseases associated with FN3K include hyperglycemia. GO annotations related to this gene include fructosamine-3-kinase activity. An important paralog of this gene is FN3KRP.

UniProtKB/Swiss-Prot for FN3K Gene

  • May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a role in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), fructoselysine, fructoseglycine, fructose and glycated lysozyme

Gene Wiki entry for FN3K Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FN3K Gene

Genomics for FN3K Gene

Genomic Location for FN3K Gene

Start:
82,735,575 bp from pter
End:
82,751,197 bp from pter
Size:
15,623 bases
Orientation:
Plus strand

Genomic View for FN3K Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FN3K Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FN3K Gene

Regulatory Elements for FN3K Gene

Proteins for FN3K Gene

  • Protein details for FN3K Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H479-FN3K_HUMAN
    Recommended name:
    Fructosamine-3-kinase
    Protein Accession:
    Q9H479
    Secondary Accessions:

    Protein attributes for FN3K Gene

    Size:
    309 amino acids
    Molecular mass:
    35171 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for FN3K Gene

Proteomics data for FN3K Gene at MOPED

Post-translational modifications for FN3K Gene

No Post-translational modifications

Other Protein References for FN3K Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FN3K Gene

Domains for FN3K Gene

UniProtKB/Swiss-Prot:

FN3K_HUMAN
Family:
  • Belongs to the fructosamine kinase family.:
    • Q9H479
genes like me logo Genes that share domains with FN3K: view

No data available for Gene Families for FN3K Gene

Function for FN3K Gene

Molecular function for FN3K Gene

UniProtKB/Swiss-Prot Function: May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a role in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), fructoselysine, fructoseglycine, fructose and glycated lysozyme

Enzyme Numbers (IUBMB) for FN3K Gene

Gene Ontology (GO) - Molecular Function for FN3K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016772 transferase activity, transferring phosphorus-containing groups --
GO:0030387 fructosamine-3-kinase activity NAS 11016445
genes like me logo Genes that share ontologies with FN3K: view

Phenotypes for FN3K Gene

genes like me logo Genes that share phenotypes with FN3K: view

Animal Models for FN3K Gene

MGI Knock Outs for FN3K:

miRNA for FN3K Gene

miRTarBase miRNAs that target FN3K

No data available for Transcription Factor Targeting and HOMER Transcription for FN3K Gene

Localization for FN3K Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FN3K Gene COMPARTMENTS Subcellular localization image for FN3K gene
Compartment Confidence
cytosol 2
nucleus 2
chloroplast 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FN3K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with FN3K: view

Pathways for FN3K Gene

SuperPathways for FN3K Gene

No Data Available

Interacting Proteins for FN3K Gene

Gene Ontology (GO) - Biological Process for FN3K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016310 phosphorylation IBA --
GO:0030389 fructosamine metabolic process IBA --
GO:0030393 fructoselysine metabolic process NAS 11016445
GO:0030855 epithelial cell differentiation IEP 21492153
genes like me logo Genes that share ontologies with FN3K: view

No data available for Pathways by source for FN3K Gene

Compounds for FN3K Gene

(1) HMDB Compounds for FN3K Gene

Compound Synonyms Cas Number PubMed IDs
Fructosamine
  • 1-Amino-1-deoxy-D-fructose
4429-04-3

(7) Novoseek inferred chemical compound relationships for FN3K Gene

Compound -log(P) Hits PubMed IDs
1-deoxy-1-morpholinofructose 98 6
fructosamine 87.6 20
lysine 47.4 3
glucose 44.8 11
glucose 6-phosphate 36 3
genes like me logo Genes that share compounds with FN3K: view

Transcripts for FN3K Gene

Unigene Clusters for FN3K Gene

Fructosamine 3 kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FN3K Gene

No ASD Table

Relevant External Links for FN3K Gene

GeneLoc Exon Structure for
FN3K
ECgene alternative splicing isoforms for
FN3K

Expression for FN3K Gene

mRNA expression in normal human tissues for FN3K Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for FN3K Gene

SOURCE GeneReport for Unigene cluster for FN3K Gene Hs.151135

mRNA Expression by UniProt/SwissProt for FN3K Gene

Q9H479-FN3K_HUMAN
Tissue specificity: Expressed in erythrocytes
genes like me logo Genes that share expressions with FN3K: view

Orthologs for FN3K Gene

This gene was present in the common ancestor of animals.

Orthologs for FN3K Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FN3K 36
  • 99.57 (n)
  • 99.35 (a)
FN3K 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FN3K 36
  • 88.13 (n)
  • 90.94 (a)
FN3K 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FN3K 36
  • 83.69 (n)
  • 85.46 (a)
FN3K 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fn3k 36
  • 84.03 (n)
  • 88.67 (a)
Fn3k 16
Fn3k 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FN3K 37
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves FN3K 36
  • 68.82 (n)
  • 73.14 (a)
FN3K 37
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FN3K 37
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fn3krp 37
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y116A8C.25 37
  • 32 (a)
OneToMany
Y116A8C.25 38
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 46 (a)
OneToMany
Species with no ortholog for FN3K:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FN3K Gene

ENSEMBL:
Gene Tree for FN3K (if available)
TreeFam:
Gene Tree for FN3K (if available)

Paralogs for FN3K Gene

Paralogs for FN3K Gene

Selected SIMAP similar genes for FN3K Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FN3K Gene

genes like me logo Genes that share paralogs with FN3K: view

Variants for FN3K Gene

Sequence variations from dbSNP and Humsavar for FN3K Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1994553 -- 82,742,836(-) TCGAC(A/G)AGGAG intron-variant
rs1994554 -- 82,742,716(-) TCAAG(A/G)GAAGC intron-variant
rs2243416 -- 82,749,052(-) TTTTA(C/T)AGATG intron-variant
rs2249113 -- 82,748,338(-) gaaac(G/T)ccatc intron-variant
rs2249116 -- 82,748,239(+) tgcct(C/G)tgggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FN3K Gene

Variant ID Type Subtype PubMed ID
nsv428351 CNV Gain 18775914
esv21913 CNV Gain+Loss 19812545
dgv3363n71 CNV Loss 21882294
nsv833575 CNV Loss 17160897
nsv909244 CNV Loss 21882294

Relevant External Links for FN3K Gene

HapMap Linkage Disequilibrium report
FN3K
Human Gene Mutation Database (HGMD)
FN3K

Disorders for FN3K Gene

(1) MalaCards Diseases for FN3K Gene

Search for FN3K Gene in MalaCards »

(1) Novoseek inferred disease relationships for FN3K Gene

Disease -log(P) Hits PubMed IDs
hyperglycemia 39.4 2

Relevant External Links for FN3K

Genetic Association Database (GAD)
FN3K
Human Genome Epidemiology (HuGE) Navigator
FN3K
genes like me logo Genes that share disorders with FN3K: view

No data available for UniProtKB/Swiss-Prot for FN3K Gene

Publications for FN3K Gene

  1. Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase. (PMID: 11016445) Delpierre G. … Van Schaftingen E. (Diabetes 2000) 3 4 23
  2. Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo. (PMID: 11522682) Szwergold B.S. … Beisswenger P.J. (Diabetes 2001) 2 3 23
  3. Fructosamine 3-kinase, an enzyme involved in protein deglycation. (PMID: 14641062) Delpierre G. … Van Schaftingen E. (Biochem. Soc. Trans. 2003) 2 3 23
  4. A polymorphism within the fructosamine-3-kinase gene is associated with HbA1c Levels and the onset of type 2 diabetes mellitus. (PMID: 19834870) MohA!s M. … Wittmann I. (Exp. Clin. Endocrinol. Diabetes 2010) 3 23 49
  5. Variability in erythrocyte fructosamine 3-kinase activity in humans correlates with polymorphisms in the FN3K gene and impacts on haemoglobin glycation at specific sites. (PMID: 16523184) Delpierre G. … Van Schaftingen E. (Diabetes Metab. 2006) 3 23

Products for FN3K Gene

  • Addgene plasmids for FN3K

Sources for FN3K Gene

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