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FN3K Gene

protein-coding   GIFtS: 54
GCID: GC17P080693

Fructosamine 3 Kinase

  See FN3K-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fructosamine 3 Kinase1 2
fructosamine-3-kinase2
EC 2.7.1.-3

External Ids:    HGNC: 248221   Entrez Gene: 641222   Ensembl: ENSG000001673637   OMIM: 6084255   UniProtKB: Q9H4793   

Export aliases for FN3K gene to outside databases

Previous GC identifers: GC17P079820 GC17P083669 GC17P081223 GC17P081372 GC17P078286 GC17P076093


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FN3K Gene:
A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and
lysine residues (glycation). Proteins modified in this way, fructosamines, are less active or functional. This
gene encodes an enzyme which catalyzes the phosphorylation of fructosamines which may result in deglycation.
(provided by RefSeq, Feb 2012)

GeneCards Summary for FN3K Gene:
FN3K (fructosamine 3 kinase) is a protein-coding gene. Diseases associated with FN3K include hyperglycemia. GO annotations related to this gene include fructosamine-3-kinase activity. An important paralog of this gene is FN3KRP.

UniProtKB/Swiss-Prot: FN3K_HUMAN, Q9H479
Function: May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a
role in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), fructoselysine, fructoseglycine, fructose and
glycated lysozyme

Gene Wiki entry for FN3K Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010663.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the FN3K gene promoter:
         SRF   Tal-1   Sp1   SRF (504 AA)   MyoD   Olf-1   E47   PPAR-alpha   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFN3K promoter sequence
   Search Chromatin IP Primers for FN3K

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FN3K


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25

FN3K Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FN3K gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P080693:  view genomic region     (about GC identifiers)

Start:
80,693,451 bp from pter      End:
80,709,073 bp from pter
Size:
15,623 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FN3K_HUMAN, Q9H479 (See protein sequence)
Recommended Name: Fructosamine-3-kinase  
Size: 309 amino acids; 35171 Da
Subunit: Monomer (Probable)

Explore the universe of human proteins at neXtProt for FN3K: NX_Q9H479

Explore proteomics data for FN3K at MOPED


See FN3K Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_071441.1  
ENSEMBL proteins: 
 ENSP00000300784  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR011009 Kinase-like_dom
 IPR016477 Fructo-/Ketosamine-3-kinase

Graphical View of Domain Structure for InterPro Entry Q9H479

ProtoNet protein and cluster: Q9H479

2 Blocks protein domains:
IPB002575 Aminoglycoside phosphotransferase
IPB005581 Fructosamine kinase


UniProtKB/Swiss-Prot: FN3K_HUMAN, Q9H479
Similarity: Belongs to the fructosamine kinase family


Find genes that share domains with FN3K           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: FN3K_HUMAN, Q9H479
Function: May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a
role in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), fructoselysine, fructoseglycine, fructose and
glycated lysozyme

     Enzyme Number (IUBMB): EC 2.7.1.-1

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016772transferase activity, transferring phosphorus-containing groups ----
GO:0030387fructosamine-3-kinase activity NAS11016445
     
Find genes that share ontologies with FN3K           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for FN3K:
 Increased apoptosis 

     3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fn3k):
 cellular  homeostasis/metabolism  renal/urinary system 

Find genes that share phenotypes with FN3K           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Fn3ktm1Mvdc for FN3K

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FN3K
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FN3K
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FN3K

miRNA
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miRTarBase miRNAs that target FN3K:
hsa-mir-335-5p (MIRT016932)

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SwitchGear 3'UTR luciferase reporter plasmidFN3K 3' UTR sequence
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Predesigned siRNA for gene silencing in human, mouse, rat FN3K

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Addgene plasmids for FN3K 

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
nucleus2
chloroplast1
mitochondrion1
peroxisome1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FN3K
Interactions:

    Search GeneGlobe Interaction Network for FN3K

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for FN3K (ENSP000003007844) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
DPYDENSP000003592114STRING: ENSP00000359211
About this table

Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0030389fructosamine metabolic process ----
GO:0030393fructoselysine metabolic process NAS11016445
GO:0030855epithelial cell differentiation IEP--

Find genes that share ontologies with FN3K           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FN3K

1 HMDB Compound for FN3K    About this table
CompoundSynonyms CAS #PubMed Ids
Fructosamine1-Amino-1-deoxy-D-fructose (see all 2)4429-04-3--

7 Novoseek inferred chemical compound relationships for FN3K gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
1-deoxy-1-morpholinofructose 98 11 15102834 (3), 15137908 (2), 14633848 (1)
fructosamine 87.6 30 14641062 (4), 15102834 (3), 15366734 (3), 16523184 (2) (see all 11)
lysine 47.4 5 15102834 (1), 11522682 (1), 17072594 (1)
glucose 44.8 15 15102834 (3), 16037310 (1), 14641081 (1), 14633848 (1) (see all 9)
glucose 6-phosphate 36 3 16670083 (3)
carbon 29.9 4 15366734 (1), 14641062 (1), 15137908 (1)
atp 12.7 3 15102834 (2)



Find genes that share compounds with FN3K           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for FN3K gene: 
NM_022158.3  

Unigene Cluster for FN3K:

Fructosamine 3 kinase
Hs.151135  [show with all ESTs]
Unigene Representative Sequence: AK054838
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000300784(uc010wvs.1) ENST00000574496 ENST00000573841 ENST00000572813
ENST00000570734(uc002kfw.1)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for FN3K
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FN3K
Addgene plasmids for FN3K 
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FN3K
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  QuantiFast Probe-based Assays in human, mouse, rat FN3K

Additional mRNA sequence: 

AJ404615.1 AK054838.1 AK294871.1 BC042680.1 

7 DOTS entries:

DT.426795  DT.95196052  DT.95341716  DT.120952214  DT.92334603  DT.40265547  DT.98084000 

Selected AceView cDNA sequences (see all 58):

CR625457 AA444040 BQ188161 BF876456 BF876028 BU849250 BF874822 BU726179 
BM817659 BU844827 BE159018 BM665193 AK054838 BQ185329 BM766754 BI754772 
BC042680 BQ648843 CD671436 AJ404615 BF874303 NM_022158 BQ944203 BQ685781 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FN3K expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CGAAGGCTGC
FN3K Expression
About this image


FN3K expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Blood (Hematopoietic System)
         Proerythroblasts Hematopoietic Bone Marrow
 
 Brain (Nervous System)
         Myelinating Oligodendrocyte Cells Forebrain White Matter
 
 Kidney (Urinary System)
FN3K Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FN3K Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.151135

UniProtKB/Swiss-Prot: FN3K_HUMAN, Q9H479
Tissue specificity: Expressed in erythrocytes

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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for FN3K gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fn3k1 , 5 fructosamine 3 kinase1, 5 84.03(n)1
88.67(a)1
  11 (85.38 cM)5
638281  NM_022014.41  NP_071297.11 
 1214349135 
chicken
(Gallus gallus)
Aves FN3K1 fructosamine 3 kinase 68.82(n)
73.14(a)
  417335  XM_415601.4  XP_415601.1 
lizard
(Anolis carolinensis)
Reptilia FN3K6
fructosamine 3 kinase
71(a)
1 ↔ 1
2(108417166-108434964)
zebrafish
(Danio rerio)
Actinopterygii fn3krp6
fructosamine-3-kinase-related protein
62(a)
1 → many
3(49381530-49390141) ENSDARG00000025086
worm
(Caenorhabditis elegans)
Secernentea Y116A8C.253   -- 35(a)   IV(17074731-17078902)   --


ENSEMBL Gene Tree for FN3K (if available)
TreeFam Gene Tree for FN3K (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FN3K gene
FN3KRP2  
1 SIMAP similar gene for FN3K using alignment to 1 protein entry:     FN3K_HUMAN:
FN3KRP

Find genes that share paralogs with FN3K           About GenesLikeMe


2 Pseudogenes.org Pseudogenes for FN3K
PGOHUM00000263067 PGOHUM00000246545


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FN3K (see all 359)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1811510421,2
--80691474(+) AACTGA/GAGCTG 1 -- us2k10--------
rs348848451,2
C,F--80691536(+) ATACCC/AAGCCA 1 -- us2k15Minor allele frequency- A:0.10NA 128
rs80818911,2
C,F,A--80691741(+) tgtcaA/C/Tgaggt 1 -- us2k15CSA WA NA EA 361
rs1406836241,2
--80691800(+) AGGCAC/GGCGGA 1 -- us2k10--------
rs1504546611,2
--80691801(+) GGCAGG/TCGGAT 1 -- us2k10--------
rs1136995271,2
C,F--80691802(+) GCAGGC/TGGATC 1 -- us2k11Minor allele frequency- T:0.50WA 2
rs1496295061,2
--80691883(+) ATTAGC/TGGGGC 1 -- us2k10--------
rs1442419761,2
C--80691896(+) GGTGAC/TGCGTG 1 -- us2k10--------
rs1390062231,2
--80691897(+) GTGACA/GCGTGC 1 -- us2k10--------
rs1859928881,2
C--80691952(+) GAACCC/TGGGAG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for FN3K (80693451 - 80709073 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for FN3K:    About this table    
Variant IDTypeSubtypePubMed ID
nsv909244CNV Loss21882294
nsv833575CNV Loss17160897
dgv3363n71CNV Loss21882294
nsv428351CNV Gain18775914
esv21913CNV Gain+Loss19812545

Human Gene Mutation Database (HGMD): FN3K
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing FN3K
DNA2.0 Custom Variant and Variant Library Synthesis for FN3K

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608425    OMIM disorders: --

1 disease for FN3K:    
About MalaCards
hyperglycemia


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1 Novoseek inferred disease relationship for FN3K gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
hyperglycemia 39.4 2 15694695 (1), 16523184 (1)

Genetic Association Database (GAD): FN3K
Human Genome Epidemiology (HuGE) Navigator: FN3K (3 documents)

Export disorders for FN3K gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FN3K gene, integrated from 10 sources (see all 32):
(articles sorted by number of sources associating them with FN3K)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo. (PubMed id 11522682)1, 3, 9 Szwergold B.S....Beisswenger P.J. (Diabetes 2001)
  2. Fructosamine 3-kinase, an enzyme involved in protein deglycation. (PubMed id 14641062)1, 3, 9 Delpierre G. and Van Schaftingen E. (Biochem. Soc. Trans. 2003)
  3. A polymorphism within the fructosamine-3-kinase gene is associated with HbA1c Levels and the onset of type 2 diabetes mellitus. (PubMed id 19834870)1, 4, 9 MohA!s M....Wittmann I. (amp 2010)
  4. Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase. (PubMed id 11016445)1, 2, 9 Delpierre G.... Van Schaftingen E. (Diabetes 2000)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Variability in erythrocyte fructosamine 3-kinase activity in humans correlates with polymorphisms in the FN3K gene and impacts on haemoglobin glycation at specific sites. (PubMed id 16523184)1, 9 Delpierre G....Van Schaftingen E. (amp 2006)
  7. Some clues as to the regulation, expression, function, and distribution of fructosamine-3-kinase and fructosamine-3-kinase-related protein. (PubMed id 16037310)1, 9 Conner J.R....Szwergold B.S. (Ann. N. Y. Acad. Sci. 2005)
  8. Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein. (PubMed id 15331600)1, 9 Delplanque J....Van Schaftingen E. (J. Biol. Chem. 2004)
  9. Identification of fructosamine residues deglycated by fructosamine-3-kinase in human hemoglobin. (PubMed id 15102834)1, 9 Delpierrre G....Van Schaftingen E. (J. Biol. Chem. 2004)
  10. The expression of the genes for fructosamine-3-kinase and fructosamine-3-kinase-related protein appears to be constitutive and unaffected by environmental signals. (PubMed id 15381090)1, 9 Conner J.R....Szwergold B.S. (Biochem. Biophys. Res. Commun. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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Aliases
Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 64122 HGNC: 24822 AceView: FN3K Ensembl:ENSG00000167363 euGenes: HUgn64122
ECgene: FN3K H-InvDB: FN3K

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FN3K Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FN3K gene:
Search GeneIP for patents involving FN3K

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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