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FN1 Gene

protein-coding GIFtS: 69

GC02M215933

fibronectin 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CIG ^¹, ², ³
DKFZp686F10164 ^²
DKFZp686H0342 ^²
DKFZp686I1370 ^²
DKFZp686O13149 ^²
ED-B ^²
FINC ^¹, ²
FN ^², ³, ⁵
FNZ ^², ⁵
GFND ^²
GFND2 ^¹, ², ⁵
LETS ^¹, ², ⁵
MSF ^¹, ²

Descriptions
Cold-insoluble globulin ^², ³
fibronectin 1 ^²
migration-stimulating factor ^²

External Ids
HGNC: 3778¹
Entrez Gene: 2335²
UniProtKB: P02751³
Ensembl: ENSG00000115414⁷

Search outside databases for aliases for FN1 gene

Previous GC identifers: GC02M214388 GC02M214950 GC02M216189 GC02M216428 GC02M216050

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FN1:

This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a

dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is

involved in cell adhesion and migration processes including embryogenesis, wound healing, blood

coagulation, host defense, and metastasis. The gene has three regions subject to alternative

splicing, with the potential to produce 20 different transcript variants. However, the full-length

nature of some variants has not been determined. [provided by RefSeq]

UniProtKB/Swiss-Prot: FINC_HUMAN, P02751

Function: Fibronectins bind cell surfaces and various compounds including collagen, fibrin,

heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization,

wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of cell

adhesion and neurite outgrowth (By similarity)

Gene Wiki entry for FN1 (Fibronectin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FN1 gene

Entrez Gene cytogenetic band: 2q34 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q34

FN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M215933: (about GC identifiers)

Start:	215,933,422 bp from pter
End:	216,009,036 bp from pter
Size:	75,615 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_005403.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FINC_HUMAN, P02751 (See protein sequence)

Recommended Name: Fibronectin precursor

Size: 2386 amino acids; 262607 Da

Subunit: Mostly heterodimers or multimers of alternatively spliced variants, connected by 2

disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP,

TNR, LGALS3BP and COL13A1. Interacts with FBLN7 (By similarity)

Subcellular location: Secreted, extracellular space, extracellular matrix

Developmental stage: Ugl-Y1, Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age

Sequence caution: Sequence=AAX76513.1; Type=Erroneous gene model prediction;

PDB structures from and Proteopedia :

1E88 (3D)

1E8B (3D)

1FBR (3D)

1FNA (3D)

1FNF (3D)

1FNH (3D)

1J8K (3D)

1O9A (3D)

1OWW (3D)

1Q38 (3D)

1QGB (3D)

1QO6 (3D)

1TTF (3D)

1TTG (3D)

2CG6 (3D)

2CG7 (3D)

2CK2 (3D)

2CKU (3D)

2EC3 (3D)

2FN2 (3D)

2FNB (3D)

2H41 (3D)

2H45 (3D)

2HA1 (3D)

2OCF (3D)

2RKY (3D)

2RKZ (3D)

2RL0 (3D)

3CAL (3D)

3EJH (3D)

Secondary accessions: O95609 O95610 Q14312 Q14325 Q14326 Q17RV7 Q585T2 Q59EH1 Q60FE4 Q68DP8 Q68DP9

Q68DT4 Q6LDP6 Q6MZU5 Q6N025 Q6N0A6 Q86T27 Q8IVI8 Q96KP7 Q96KP8 Q96KP9 Q9H1B8 Q9HAP3 Q9UMK2

Alternative splicing: 15 isoforms: P02751-1 P02751-2 P02751-3 P02751-4 P02751-5 P02751-6 P02751-7 P02751-8

P02751-9 P02751-10 P02751-11 P02751-12 P02751-13 P02751-14 P02751-15 (Additional isoforms seem to exist)

Post-translational modifications:

Sulfated¹

It is not known whether both or only one of Thr-2064 and Thr-2065 are/is glycosylated¹

Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a

glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers

(e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (7 alternative transcripts):

NP_002017.1 NP_473375.2 NP_997639.1 NP_997640.1 NP_997641.1 NP_997643.1 NP_997647.1

ENSEMBL proteins:

ENSP00000346839 ENSP00000323534 ENSP00000265313 ENSP00000352696 ENSP00000338200 ENSP00000348285

ENSP00000265312 ENSP00000273049 ENSP00000350534 ENSP00000349509

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant FN1 Protein
	Sigma-Aldrich Proteins for FN1
	R&D Systems Recombinant & Natural Proteins for FN1 (Fibronectin)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Fibronectin Cell Binding Site , Fibronectin, Fibronectin Fragment III.1 )
	Human Recombinant Proteins from Abnova (FN1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574
GO:0005577	fibrinogen complex	IDA	3997886
GO:0005578	proteinaceous extracellular matrix	NAS	--
GO:0005793	ER-Golgi intermediate compartment	IDA	15308636
GO:0031093	platelet alpha granule lumen	EXP	444675

About this table

Antibodies for FN1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of FN1
	Sigma-Aldrich Antibody Arrays and Antibodies for FN1
	R&D Systems Antibodies for FN1 (Fibronectin)
	Antibodies from Abcam (Fibronectin Cell Binding Site , Fibronectin, Fibronectin Fragment III.1 ), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FN1)
	Novus Biologicals Antibodies for FN1

Assays for FN1:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of FN1
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P02751

ProtoNet protein and cluster: P02751

3 Blocks protein families:

IPB000083 Fibronectin

IPB000562 Type II fibronectin collagen-binding domain

IPB003962 Fibronectin type III repeat signature

UniProtKB/Swiss-Prot: FINC_HUMAN, P02751

Similarity: Contains 12 fibronectin type-I domains

Similarity: Contains 2 fibronectin type-II domains

Similarity: Contains 16 fibronectin type-III domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FN1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7): NM_212474

Applied Biosystems Silencer® siRNAs for FN1

Sigma-Aldrich siRNA and siRNA Panels for FN1

Sigma-Aldrich shRNA Panels and shRNA for FN1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 7): NM_002026
Myc/DDK tagged cDNA clones in CMV expression vector (see all 7): NM_002026
untagged cDNA clones in CMV expression vector (see all 7): NM_002026

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_212482

UniProtKB/Swiss-Prot: FINC_HUMAN, P02751

Function: Fibronectins bind cell surfaces and various compounds including collagen, fibrin,

heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization,

wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of cell

adhesion and neurite outgrowth (By similarity)

Genatlas biochemistry entry for FN1:

fibronectin 1,plasma,cell adhesion factor,playing a role in the susceptibility to lung fibrosing

alveolitis in systemic sclerosis,overexpressed in prostate cancer cells

15/17 MGI mutant phenotypes (inferred from 11 alleles) (MGI details for Fn1) (see all 17 ):

	cellular	embryogenesis	growth/size	hematopoietic system
homeostasis/metabolism	immune system	lethality-prenatal/perinatal	life span-post-weaning/aging	muscle
nervous system	normal	other	reproductive system	skeleton

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005201	extracellular matrix structural constituent	NAS	--
GO:0005518	collagen binding	NAS	3024962
GO:0008201	heparin binding	NAS	10075919

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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for FN1 (Your Favorite Gene powered by Ingenuity)

Hepatic Fibrosis / Hepatic Stellate Cell Activation
Acute Phase Response Signaling
Actin Cytoskeleton Signaling

GeneDecks FN1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for FN1

5/302 Interacting proteins for FN1 (P02751² ENSP00000323534³) via UniProtKB, MINT, and/or STRING (see all 302 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CTGF	P29279², ENSP00000356954³	MINT-1781130 MINT-1781181 MINT-1781150 MINT-1780780 MINT-1779933 STRING (score=.987)
SCGB1A1	P11684², ENSP00000278282³	MINT-6491137 MINT-6491111 MINT-6491129 STRING (score=.933)
VHL	P40337², ENSP00000256474³	MINT-6543105 MINT-6542668 STRING (score=.96)
ITGA5	P08648², ENSP00000293379³	MINT-1781205 STRING (score=.999)
CD79A	P11912², ENSP00000221972³	MINT-6491150 STRING (score=.948)

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006953	acute-phase response	IEA	--
GO:0007155	cell adhesion	NAS	1423622
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	NAS	15609325
GO:0008360	regulation of cell shape	IEA	--
GO:0009611	response to wounding	NAS	7989369

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FN1
10/45 Novoseek chemical compound relationships for FN1 gene (see all 45 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
grgdsp	73.18	11	1701798 (1), 15625681 (1), 8929455 (1), 7515098 (1) (see all 7)
grgesp	61.76	5	7544537 (1), 7515098 (1), 7563001 (1)
fibronectins	59.58	5	9502075 (2), 8635499 (1)
fibrinogen	56.91	189	8905624 (7), 9721590 (5), 9613806 (5), 1717474 (4) (see all 59)
ag957	56.15	2	9823945 (1), 11480565 (1)
dimethyldichlorosilane	48.07	1	10571906 (1)
tgf beta1	48.06	22	17347580 (5), 11887862 (3), 16686283 (3), 15668800 (2) (see all 10)
tyrosine	44.50	58	7843239 (3), 9351362 (3), 12361810 (2), 7691611 (2) (see all 35)
latex	43.64	63	12778079 (5), 14751515 (5), 18228272 (4), 7689568 (3) (see all 22)
thermolysin	38.73	11	2098103 (1), 9648240 (1), 19404402 (1), 2351703 (1) (see all 6)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FN1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7): NM_212474

Sigma-Aldrich siRNA and siRNA Panels for FN1

Sigma-Aldrich shRNA Panels and shRNA for FN1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002026 NM_054034 NM_212474 NM_212475 NM_212476 NM_212478 NM_212482

REFSEQ mRNAs for FN1 gene (7 alternative transcripts):

NM_002026.2 NM_054034.2 NM_212474.1 NM_212475.1 NM_212476.1 NM_212478.1 NM_212482.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002026 NM_054034 NM_212474 NM_212475 NM_212476 NM_212478 NM_212482

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 7): NM_002026
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 7): NM_002026
                                 untagged cDNA clones in CMV expression vector (see all 7): NM_002026

Additional cDNA sequence:

AB191261.1 AB209287.1 AB209840.1 AF312399.1 AJ276395.1 AJ320525.1 AJ320526.1 AJ320527.1

AJ535086.1 AJ849445.1 AK026737.1 AK094153.1 AK094277.1 AK297733.1 AK300216.1 AK300246.1

AK300458.1 AK316350.1 AL832202.1 AL832771.1 AY450391.1 BC005858.2 BC016875.2 BC078656.1

BC100030.1 BC117176.1 BC143754.1 BC143763.1 BT006856.1 BX537590.1 BX538017.1 BX538018.1

BX538045.1 BX640608.1 BX640638.1 BX640731.1 BX640802.1 BX640803.1 BX640875.1 BX640920.1

BX640999.1 BX649182.1 CR593359.1 CR598146.1 CR601543.1 CR602860.1 CR606847.1 CR611619.1

CR749281.1 CR749316.1 CR749317.1 CR749666.1 CR936623.1 EF550130.1 EF550131.1 EF550132.1

EF550133.1 EF550134.1 EF550135.1 M10905.1 M27589.1 M27590.1 U41724.1 U41850.1

U42404.1 U42455.1 U42456.1 U42457.1 U42458.1 U42592.1 U42593.1 U42594.1

U60067.1 U60068.1 X02761.1

24/170 DOTS entries (see all 170 ):

DT.100713754 DT.95155416 DT.95155376 DT.95228807 DT.100049467 DT.87077684 DT.100869613 DT.91874185

DT.101987447 DT.100713740 DT.100713757 DT.100713756 DT.92377155 DT.100713758 DT.100713727 DT.95098238

DT.100713746 DT.95079938 DT.100713783 DT.92476195 DT.92412233 DT.95155519 DT.100713781 DT.91804107

24/2170 AceView cDNA sequences (see all 2170 ):

BQ182815 BQ181808 AA359459 BQ008717 CA427900 AA565678 AI754778 BP364228

CA435480 AW771185 CA412999 BQ007633 BQ183185 BQ181220 AU120167 CO250183

AU135716 BQ181498 AA158272 CN482351 BU616067 BP337397 BX416961 M14059

highest scoring ESTs for FN1:

X02761 AJ535086 AL596503 AL603192 AL603224 AL603362 AL698351 AL698360 AL698361 AL698416

Unigene Cluster for FN1:

Fibronectin 1

Hs.203717 [show with all ESTs]

Unigene Representative Sequence: NM_212482

GeneLoc Exon Structure

5/19 Alternative Splicing Database (ASD) splice patterns (SP) for FN1 (see all 19 )

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14a	·	14b	^	15	^	16a	·	16b	^	17	^	18	^	19	^	20	^	21	^	22	^
SP1:																													-
SP2:																													-
SP3:																													-
SP4:																													-
SP5:																													-

ExUns:	23	^	24a	·	24b	^	25	^	26	^	27	^	28	^	29	^	30a	·	30b	^	31	^	32a	·	32b	^	33a	·	33b	^	34a	·	34b	·	34c	^	35	^	36	^	37a	·	37b	^	38	^	39	^	40	^	41a	·
SP1:																	-								-		-				-																				-
SP2:							-										-								-		-				-																				-
SP3:																	-								-		-				-																				-
SP4:							-										-								-		-				-																				-
SP5:							-										-								-		-		-		-																				-

ExUns:	41b	·	41c	^	42a	·	42b	^	43a	·	43b	·	43c	·	43d	^	44a	·	44b	^	45a	·	45b	·	45c	^	46a	·	46b	^	47a	·	47b	^	48a	·	48b
SP1:									-										-		-		-						-		-
SP2:									-										-		-		-						-		-
SP3:									-										-		-		-						-		-
SP4:	-								-										-		-		-						-		-
SP5:									-										-		-		-						-		-

About this scheme

ECgene alternative splicing isoforms for FN1

10 Ensembl transcripts including schematic representations:

ENST00000354785 ENST00000323926 ENST00000265313 ENST00000359671 ENST00000336916 ENST00000356005

ENST00000346544 ENST00000345488 ENST00000357867 ENST00000357009

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FN1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FN1

¹ / ² / ³

18 probe-sets matching FN1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31720_s_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.27	M10905	0.80	1.00	0.91	1
45557_r_at²^{, 3}	U95-B	1	1.00	1.00	0.86	0.84	AW021977	0.40	0.67	0.55	1
311_s_at²^{, 3}	U95-A	1	1.00	1.00	0.98	1.22	HG3044-HT3742	0.20	1.00	0.72	1
31719_at²^{, 3}	U95-A	1	1.00	1.00	0.98	1.36	X02761	1.00	1.00	1.00	1
64719_at²^{, 3}	U95-C	1	0.94	1.00	0.70	0.35	AI275123	0.60	1.00	0.82	1
211719_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC005858	0.60	1.00	0.82	1
216442_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK026737	0.60	1.00	0.82	1
214702_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AJ276395	0.60	1.00	0.82	1
210495_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF130095	0.20	1.00	0.72	1
214701_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AJ276395	0.60	1.00	0.82	1
212464_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	X02761	1.00	1.00	1.00	1
211719_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1558199_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216442_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214702_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210495_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214701_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212464_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks FN1 for binary patterns associated with the probe-sets selected above

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About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATCTTGTTAC

SOURCE GeneReport for Unigene cluster: Hs.203717
Expression variation in blood from EXPOLDB for FN1
UniProtKB/Swiss-Prot: FINC_HUMAN, P02751
Tissue specificity: Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN
(dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types,
is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FN1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FN1¹	--	fibronectin 1	90.93(n) 95.19(a)	403845 XM_536059.2 XP_536059.2
chimpanzee (Pan troglodytes)	FN1¹	--	fibronectin 1	99.37(n) 99.68(a)	459926 XM_516072.2 XP_516072.2
cow (Bos taurus)	FN1¹	--	fibronectin 1	90.44(n) 94.03(a)	280794 XM_874054.2 XP_879147.1
rat (Rattus norvegicus)	Fn1¹	--	fibronectin 1	87.29(n) 92.28(a)	25661 NM_019143.1 NP_062016.1
mouse (Mus musculus)	Fn1^{1, 5}	1 (36.10 cM)⁵	fibronectin 1^{1, 5}	87.52(n)¹ 92.2(a)¹	14268¹ NM_010233.1¹ NP_034363.1¹ AA600547⁵ AF095690⁵ (see all 40)

About this table Species with no ortholog for FN1

ENSEMBL Gene Tree for FN1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/551 NCBI SNPs in FN1 are shown (see all 551 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 210)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1250259^1,2	A,C,F,H	216008727(+)	`GGCACA/TGGACG`	7	Q/L	mis¹ ese³		6	EA EU WA NA	1974
	rs1263^1,2	A,C,F,H	215933588(+)	`TTTTAA/GTAAAT`	6	--	ut3¹		6	MN EU EA WA NA	1483
	rs17516906^1,2	C,F,H	215987518(+)	`TTATCA/GTTTCT`	7	--	int¹ ng5¹		7	NA EU EA WA	562
	rs6728999^1,2	C,F,H	215943291(+)	`CTTCCC/TGAACC`	6	R/Q	mis¹ ese³		9	EU EA WA NA	904
	rs17449032^1,2	C,F,H	215944957(+)	`TGAGAT/CGGTTG`	6	V/I	mis¹ ese³		12	NA EU EA WA	1040
	rs2577301^1,2	C,H	215981145(+)	`AGTCGG/TGTCAG`	6	P/T	mis¹ ese³		4	EU EA WA	416
	rs1250267^1,2	F,H	215987328(+)	`TAAATT/ACAGTG`	7	--	int¹ ng5¹ ese³		4	EU EA WA	420
	rs1250209^1,2	C,H	215943334(-)	`ACAACA/GTCATA`	6	I/V	mis¹ ese³		5	MN EU EA WA	602
	rs1058361^1,2	C,H	215945007(-)	`TCCGGG/TACTCA`	6	G/V	mis¹ int¹ ese³		8	EU EA WA	808
	rs1264^1,2	A,F	215933597(+)	`ATATTG/TGGGTC`	6	--	ut3¹ ese³		1	MN	184

About this table

HapMap Linkage Disequilibrium images for FN1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 135600 disorders: 601894

UniProtKB/Swiss-Prot: FINC_HUMAN, P02751

Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2)

[MIM:601894]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin

glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized

clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal

failure in the second to fifth decade of life

10/95 Novoseek disease relationships for FN1 gene (see all 95 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fibrosarcoma	39.22	16	17575686 (2), 7867715 (1), 12225805 (1), 17187346 (1) (see all 11)
tumors	37.30	151	1612776 (4), 10656615 (4), 1512857 (3), 8394677 (3) (see all 93)
ehlers-danlos syndrome	36.42	6	10651716 (1), 18405669 (1), 15054833 (1), 8186768 (1) (see all 5)
myeloma	36.18	17	7947265 (3), 10980607 (3), 9803879 (2), 8260708 (1) (see all 10)
malignant ascites	35.52	1	9428492 (1)
inflammation	33.04	42	11332203 (3), 15193149 (3), 10365576 (3), 1942612 (1) (see all 29)
nephropathy iga	32.48	9	2198363 (3), 12200800 (1), 8022108 (1), 10374298 (1) (see all 6)
renal fibrosis	32.34	2	19229829 (1)
vitreoretinopathy proliferative	31.92	4	7956309 (1), 7514582 (1), 11864408 (1)
epiretinal membrane	31.57	1	7514582 (1)

About this table

Human Gene Mutation Database: FN1
Genetic Association Database: FN1
Human Genome Epidemiology Navigator: FN1 (8 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1062 PubMed articles for FN1 gene (see all 1062 ):

Evolution of the fibronectin gene. Exon structure of cell attachment domain. (PubMed id 3003095)^{2, 3, 4} Oldberg A. and Ruoslahti E. (1986)
Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene. (PubMed id 2992939)^{2, 3, 4} Kornblihtt A.R.... Baralle F.E. (1985)
Mutations in FN1 cause glomerulopathy with fibronectin deposits. (PubMed id 18268355)^{1, 3, 4} Castelletti F.... Noris M. (2008)
Phenotypic and genetic alterations in mammary stroma: implications for tumour progression. (PubMed id 11737888)^{1, 3, 4} Schor S.L. and Schor A.M. (2001)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)
Vector-capping: a simple method for preparing a high-quality full- length cDNA library. (PubMed id 16106752)^{3, 4} Kato S.... Kimura T. (2005)
Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)^{3, 4} Bunkenborg J.... Wisniewski J.R. (2004)
Association study between the fibronectin gene and schizophrenia. (PubMed id 12497612)^{3, 6} Nakata K....Kuroda S. (2003)
Pathogenic bacteria attach to human fibronectin through a tandem beta-zipper. (PubMed id 12736686)^{3, 4} Schwarz-Linek U.... Potts J.R. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2335	HGNC: 3778	AceView: FN1	Ensembl:ENSG00000115414	euGenes: HUgn2335
ECgene: FN1	H-InvDB: FN1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for FN1	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Fibronectin

Licensable Technologies for FN1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for FN1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

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Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
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	Millipore Custom Antibody & Bulk Services
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Antibodies for FN1

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FN1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for FN1

Summaries
for FN1

Genomic Location
for FN1

Proteins
for FN1

Protein Domains/
Families
for FN1

Gene Function
for FN1

Pathways & Interactions
for FN1

Drugs & Compounds
for FN1

Transcripts
for FN1

Expression
for FN1

Orthologs
for FN1

Paralogs
for FN1

SNPs/Variants
for FN1

Disorders & Mutations
for FN1

Medical News
for FN1

Publications
for FN1

Search for FN1

Genome Databases showing FN1

Other Databases showing FN1

Specialized Databases showing FN1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FN1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor FN1

Summariesfor FN1

Genomic Locationfor FN1

Proteinsfor FN1

Protein Domains/Familiesfor FN1

Gene Functionfor FN1

Pathways & Interactionsfor FN1

Drugs & Compoundsfor FN1

Transcriptsfor FN1

Expression for FN1

Orthologsfor FN1

Paralogsfor FN1

SNPs/Variantsfor FN1

Disorders & Mutationsfor FN1

Medical Newsfor FN1

Publicationsfor FN1

Search for FN1

Genome Databases showing FN1

Other Databases showing FN1

Specialized Databases showing FN1

Licensable Technologiesfor FN1

Servicesfor FN1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FN1

Summaries
for FN1

Genomic Location
for FN1

Proteins
for FN1

Protein Domains/
Families
for FN1

Gene Function
for FN1

Pathways & Interactions
for FN1

Drugs & Compounds
for FN1

Transcripts
for FN1

Expression
for FN1

Orthologs
for FN1

Paralogs
for FN1

SNPs/Variants
for FN1

Disorders & Mutations
for FN1

Medical News
for FN1

Publications
for FN1

Licensable Technologies
for FN1

Services
for FN1