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Aliases for FN1 Gene

Aliases for FN1 Gene

  • Fibronectin 1 2 3 5
  • Cold-Insoluble Globulin 2 3 4
  • Migration-Stimulating Factor 2 3
  • CIG 3 4
  • FN 3 4
  • GFND2 3
  • ED-B 3
  • FINC 3
  • GFND 3
  • LETS 3
  • FNZ 3
  • MSF 3

External Ids for FN1 Gene

Previous GeneCards Identifiers for FN1 Gene

  • GC02M214388
  • GC02M214950
  • GC02M216189
  • GC02M216428
  • GC02M216050
  • GC02M215933
  • GC02M216225
  • GC02M208082

Summaries for FN1 Gene

Entrez Gene Summary for FN1 Gene

  • This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]

GeneCards Summary for FN1 Gene

FN1 (Fibronectin 1) is a Protein Coding gene. Diseases associated with FN1 include glomerulopathy with fibronectin deposits 2 and plasma fibronectin deficiency. Among its related pathways are Platelet activation, signaling and aggregation and Degradation of the extracellular matrix. GO annotations related to this gene include heparin binding and protease binding. An important paralog of this gene is FCN2.

UniProtKB/Swiss-Prot for FN1 Gene

  • Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.

  • Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.

Gene Wiki entry for FN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FN1 Gene

Genomics for FN1 Gene

Regulatory Elements for FN1 Gene

Promoters for FN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FN1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FN1 gene promoter:

Genomic Location for FN1 Gene

Chromosome:
2
Start:
215,360,440 bp from pter
End:
215,436,172 bp from pter
Size:
75,733 bases
Orientation:
Minus strand

Genomic View for FN1 Gene

Genes around FN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FN1 Gene

Proteins for FN1 Gene

  • Protein details for FN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02751-FINC_HUMAN
    Recommended name:
    Fibronectin
    Protein Accession:
    P02751
    Secondary Accessions:
    • B7ZLF0
    • E9PE77
    • E9PG29
    • O95609
    • O95610
    • Q14312
    • Q14325
    • Q14326
    • Q17RV7
    • Q564H7
    • Q585T2
    • Q59EH1
    • Q60FE4
    • Q68DP8
    • Q68DP9
    • Q68DT4
    • Q6LDP6
    • Q6MZS0
    • Q6MZU5
    • Q6N025
    • Q6N0A6
    • Q7Z391
    • Q86T27
    • Q8IVI8
    • Q96KP7
    • Q96KP8
    • Q96KP9
    • Q9H1B8
    • Q9HAP3
    • Q9UMK2

    Protein attributes for FN1 Gene

    Size:
    2386 amino acids
    Molecular mass:
    262625 Da
    Quaternary structure:
    • Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1. Interacts with FBLN7 (By similarity). Interacts with COMP. Interacts with S.aureus fnbA. Interacts with TNR; the interaction inhibits cell adhesion and neurite outgrowth (By similarity). Interacts with FST3 and MYOC.
    SequenceCaution:
    • Sequence=AAX76513.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAD93077.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD91166.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD97964.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD97965.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD97984.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH18136.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FN1 Gene

neXtProt entry for FN1 Gene

Proteomics data for FN1 Gene at MOPED

Post-translational modifications for FN1 Gene

  • Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers).
  • It is not known whether both or only one of Thr-2064 and Thr-2065 are/is glycosylated.
  • Phosphorylated by FAM20C in the extracellular medium.
  • Proteolytic processing produces the C-terminal NC1 peptide, anastellin.
  • Sulfated.
  • Ubiquitination at Lys 1050
  • Glycosylation at Thr 278, Thr 279, Ser 280, Ser 281, Ser 283, Thr 287, Asn 430, Asn 528, Asn 542, Asn 877, Asn 1007, Asn 1244, Thr 1276, Ser 1566, Thr 1641, Thr 1999, Thr 2061, Thr 2064, Thr 2065, Thr 2067, Asn 2108, Ser 2341, Thr 2345, Thr 2346, and Ser 2349
  • Modification sites at PhosphoSitePlus

Protein Products

Assay Products

  • Enzo Life Sciences assays for FN1

No data available for DME Specific Peptides for FN1 Gene

Domains & Families for FN1 Gene

Graphical View of Domain Structure for InterPro Entry

P02751

UniProtKB/Swiss-Prot:

FINC_HUMAN :
  • Contains 12 fibronectin type-I domains.
Domain:
  • Contains 12 fibronectin type-I domains.
  • Contains 2 fibronectin type-II domains.
  • Contains 16 fibronectin type-III domains.
genes like me logo Genes that share domains with FN1: view

Function for FN1 Gene

Molecular function for FN1 Gene

GENATLAS Biochemistry:
fibronectin 1,plasma,cell adhesion factor,playing a role in the susceptibility to lung fibrosing alveolitis in systemic sclerosis,overexpressed in prostate cancer cells
UniProtKB/Swiss-Prot Function:
Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.
UniProtKB/Swiss-Prot Function:
Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.

LifeMap Function Summary for FN1 Gene

FN1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for FN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IPI 11792823
genes like me logo Genes that share ontologies with FN1: view
genes like me logo Genes that share phenotypes with FN1: view

Human Phenotype Ontology for FN1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FN1 Gene

MGI Knock Outs for FN1:

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FN1 Gene

Localization for FN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FN1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FN1 Gene COMPARTMENTS Subcellular localization image for FN1 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 3
nucleus 3
cytosol 2
endoplasmic reticulum 2
golgi apparatus 2
lysosome 2
mitochondrion 2
vacuole 2
endosome 1

Gene Ontology (GO) - Cellular Components for FN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005604 basement membrane IEA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with FN1: view

Pathways & Interactions for FN1 Gene

SuperPathways for FN1 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Integrin Pathway
3 ERK Signaling
4 Platelet activation, signaling and aggregation
5 Integrin alphaIIb beta3 signaling
genes like me logo Genes that share pathways with FN1: view

SIGNOR curated interactions for FN1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for FN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001775 cell activation IEA --
GO:0002576 platelet degranulation TAS --
GO:0002931 response to ischemia IEA --
GO:0006953 acute-phase response IEA --
genes like me logo Genes that share ontologies with FN1: view

Drugs & Compounds for FN1 Gene

(52) Drugs for FN1 Gene - From: Novoseek, HMDB, DGIdb, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist 719,239
Ocriplasmin Approved Pharma Target, cleavage 0
Aldosterone Experimental Pharma Agonist 0
AS1409 Investigational Pharma binder 0
1311-L19SIP Pharma Antibody Others 0

(71) Additional Compounds for FN1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FN1: view

Transcripts for FN1 Gene

Unigene Clusters for FN1 Gene

Fibronectin 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FN1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

ExUns: 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b ^ 33a · 33b ^ 34a · 34b · 34c ^ 35 ^ 36 ^ 37a · 37b ^ 38 ^ 39 ^ 40 ^ 41a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8:
SP9:
SP10: -
SP11: -
SP12:
SP13:
SP14:
SP15: -
SP16:
SP17:
SP18:
SP19:

ExUns: 41b · 41c ^ 42a · 42b ^ 43a · 43b · 43c · 43d ^ 44a · 44b ^ 45a · 45b · 45c ^ 46a · 46b ^ 47a · 47b ^ 48a · 48b
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - -
SP8:
SP9:
SP10: -
SP11: - -
SP12: - -
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:
SP19:

Relevant External Links for FN1 Gene

GeneLoc Exon Structure for
FN1
ECgene alternative splicing isoforms for
FN1

Expression for FN1 Gene

mRNA expression in normal human tissues for FN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FN1 Gene

This gene is overexpressed in Artery - Coronary (x5.5) and Artery - Aorta (x5.4).

Protein differential expression in normal tissues from HIPED for FN1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (40.8) and Amniocyte (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FN1 Gene



SOURCE GeneReport for Unigene cluster for FN1 Gene Hs.203717

mRNA Expression by UniProt/SwissProt for FN1 Gene

P02751-FINC_HUMAN
Tissue specificity: Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.
genes like me logo Genes that share expression patterns with FN1: view

Protein tissue co-expression partners for FN1 Gene

Primer Products

In Situ Assay Products

Orthologs for FN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FN1 36
  • 100 (a)
OneToOne
FN1 35
  • 99.37 (n)
  • 99.68 (a)
cow
(Bos Taurus)
Mammalia FN1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FN1 36
  • 95 (a)
OneToOne
FN1 35
  • 90.91 (n)
  • 95.07 (a)
mouse
(Mus musculus)
Mammalia Fn1 36
  • 92 (a)
OneToOne
Fn1 35
  • 87.33 (n)
  • 91.84 (a)
Fn1 16
oppossum
(Monodelphis domestica)
Mammalia FN1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FN1 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fn1 35
  • 87.18 (n)
  • 92.16 (a)
chicken
(Gallus gallus)
Aves FN1 35
  • 77.72 (n)
  • 82 (a)
FN1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FN1 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia fibronectin 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fn1 35
  • 69.77 (n)
  • 72.28 (a)
Str.6682 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3745 35
zebrafish
(Danio rerio)
Actinopterygii col12a1b 36
  • 15 (a)
OneToMany
FN1 (4 of 4) 36
  • 20 (a)
OneToMany
fn1a 36
  • 58 (a)
OneToMany
fn1b 36
  • 55 (a)
OneToMany
fn1 35
fn1a 35
  • 61.76 (n)
  • 59.79 (a)
worm
(Caenorhabditis elegans)
Secernentea D1009.3 36
  • 11 (a)
OneToOne
Species with no ortholog for FN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FN1 Gene

ENSEMBL:
Gene Tree for FN1 (if available)
TreeFam:
Gene Tree for FN1 (if available)

Paralogs for FN1 Gene

Paralogs for FN1 Gene

genes like me logo Genes that share paralogs with FN1: view

Variants for FN1 Gene

Sequence variations from dbSNP and Humsavar for FN1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs724617 -- 215,417,758(+) TAGGA(A/G)TAAGG intron-variant
rs1053238 -- 215,404,486(-) TACCC(A/C)CTGAG reference, synonymous-codon
rs1058361 -- 215,372,039(-) TCCGG(A/G/T)ACTCA intron-variant, reference, missense
rs1313044 -- 215,370,665(-) GCACG(C/T)AGGTA intron-variant
rs1250201 -- 215,385,096(-) TACAC(A/G)TAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FN1 Gene

Variant ID Type Subtype PubMed ID
esv33472 CNV Loss 17666407
dgv1288e1 CNV Complex 17122850

Variation tolerance for FN1 Gene

Residual Variation Intolerance Score: 13.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.63; 72.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FN1 Gene

HapMap Linkage Disequilibrium report
FN1
Human Gene Mutation Database (HGMD)
FN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FN1 Gene

Disorders for FN1 Gene

MalaCards: The human disease database

(70) MalaCards diseases for FN1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
glomerulopathy with fibronectin deposits 2
  • fibronectin glomerulopathy
plasma fibronectin deficiency
mycobacterium kansasii
  • m. kansasii
secondary syphilis
  • secondary syphilis of viscera or bone
vitreous disease
  • disorder of vitreous body
- elite association - COSMIC cancer census association via MalaCards
Search FN1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FINC_HUMAN
  • Glomerulopathy with fibronectin deposits 2 (GFND2) [MIM:601894]: Genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. {ECO:0000269 PubMed:18268355}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FN1

Genetic Association Database (GAD)
FN1
Human Genome Epidemiology (HuGE) Navigator
FN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FN1
genes like me logo Genes that share disorders with FN1: view

No data available for Genatlas for FN1 Gene

Publications for FN1 Gene

  1. Evolution of the fibronectin gene. Exon structure of cell attachment domain. (PMID: 3003095) Oldberg A. … Ruoslahti E. (J. Biol. Chem. 1986) 2 3 4 67
  2. A novel fibronectin binding motif in MSCRAMMs targets F3 modules. (PMID: 19404402) Prabhakaran S. … HAPAPk M. (PLoS ONE 2009) 3 23
  3. Coordinate regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by the G protein-coupled receptor, GPR30. (PMID: 19342448) Quinn J.A. … Filardo E.J. (Mol. Endocrinol. 2009) 3 23
  4. Interleukin-18 stimulates fibronectin expression in primary human cardiac fibroblasts via PI3K-Akt-dependent NF-kappaB activation. (PMID: 18064631) Reddy V.S. … Chandrasekar B. (J. Cell. Physiol. 2008) 3 23
  5. Interactions of the streptococcal C5a peptidase with human fibronectin. (PMID: 18313373) Hull J.R. … Castner D.G. (Acta Biomater 2008) 3 23

Products for FN1 Gene

  • Addgene plasmids for FN1

Sources for FN1 Gene

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