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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FN1 Gene

protein-coding GIFtS: 72
GCID: GC02M216225

fibronectin 1

Explore 185 diseases affiliated with
FN1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Fibronectin 1¹ ²		Cold-Insoluble Globulin² ³
CIG¹ ² ³		FNZ² ⁵
GFND2¹ ² ⁵		ED-B²
LETS¹ ² ⁵		GFND²
FN² ³ ⁵		Fibronectin¹
FINC¹ ²		Migration-Stimulating Factor²
MSF¹ ²

External Ids:	HGNC: 3778¹	Entrez Gene: 2335²	Ensembl: ENSG00000115414⁷	OMIM: 135600⁵	UniProtKB: P02751³

Export aliases for FN1 gene to outside databases

Previous GC identifers: GC02M214388 GC02M214950 GC02M216189 GC02M216428 GC02M216050 GC02M215933 GC02M208082

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FN1:

This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or

multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and

migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene

has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants.

However, the full-length nature of some variants has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FINC_HUMAN, P02751

Function: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin.

Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape

Function: Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin,

exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and

metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling

Gene Wiki entry for FN1 (Fibronectin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FN1 gene promoter:
AP-1 STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): FN1 promoter sequence

Search SABiosciences Chromatin IP Primers for FN1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FN1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q34 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q34

FN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FN1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M216225: view genomic region (about GC identifiers)

Start:	216,225,163 bp from pter	End:	216,300,895 bp from pter
Size:	75,733 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FINC_HUMAN, P02751 (See protein sequence)

Recommended Name: Fibronectin precursor

Size: 2386 amino acids; 262625 Da

Subunit: Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the

carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1. Interacts with

FBLN7 (By similarity). Interacts with COMP. Interacts with S.aureus fnbA. Interacts with TNR; the interaction inhibits

cell adhesion and neurite outgrowth (By similarity). Interacts with FST3

Subcellular location: Secreted, extracellular space, extracellular matrix

Developmental stage: Ugl-Y1, Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age

Sequence caution: Sequence=AAX76513.1; Type=Erroneous gene model prediction; Sequence=BAD93077.1; Type=Erroneous

initiation; Note=Translation N-terminally shortened; Sequence=CAD91166.1; Type=Erroneous initiation; Note=Translation

N-terminally shortened; Sequence=CAD97964.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Sequence=CAD97965.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAH18136.1;

Type=Erroneous initiation; Note=Translation N-terminally shortened;

6/37 PDB 3D structures from and Proteopedia for FN1 (see all 37):

1E88 (3D)

1E8B (3D)

1FBR (3D)

1FNA (3D)

1FNF (3D)

1FNH (3D)

Secondary accessions: O95609 O95610 Q14312 Q14325 Q14326 Q17RV7 Q585T2 Q59EH1 Q60FE4 Q68DP8 Q68DP9

Q68DT4 Q6LDP6 Q6MZS0 Q6MZU5 Q6N025 Q6N0A6 Q86T27 Q8IVI8 Q96KP7 Q96KP8 Q96KP9 Q9H1B8 Q9HAP3 Q9UMK2

Alternative splicing: 15 isoforms: P02751-1 P02751-2 P02751-3 P02751-4 P02751-5 P02751-6 P02751-7 P02751-8

P02751-9 P02751-10 P02751-11 P02751-12 P02751-13 P02751-14 P02751-15 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FN1: NX_P02751

Post-translational modifications:

Sulfated¹

It is not known whether both or only one of Thr-2064 and Thr-2065 are/is glycosylated¹

Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the

epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin,

collagen-fibronectin heteropolymers)¹

Phosphorylation sites are present in the extracellular medium¹

Proteolytic processing produces the C-terminal NC1 peptide, anastellin¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P02751

FN1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_002017.1 NP_473375.2 NP_997639.1 NP_997641.1 NP_997643.1 NP_997647.1

ENSEMBL proteins:

ENSP00000394423 ENSP00000323534 ENSP00000338200 ENSP00000350534 ENSP00000346839

ENSP00000410422 ENSP00000415018 ENSP00000399538 ENSP00000348285 ENSP00000416139

ENSP00000392565 ENSP00000398907 ENSP00000352696 ENSP00000265312 ENSP00000273049

ENSP00000349509

Reactome Protein details: P02751
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant FN1 Protein
	R&D Systems Recombinant & Natural Proteins for FN1 (Fibronectin)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): FN1 OriGene Custom Protein Services for FN1
	GenScript Custom Purified and Recombinant Proteins Services for FN1
	Novus Biologicals FN1 Proteins Novus Biologicals FN1 Lysates
	Sino Biological Recombinant Protein for FN1
	ProSpec Recombinant Protein for FN1
	Uscn Proteins for FN1

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005577	fibrinogen complex	IDA	3997886
GO:0005578	proteinaceous extracellular matrix	NAS	--
GO:0005604	basement membrane	IEA	--
GO:0005615	extracellular space	IDA	--

FN1 for ontologies About GeneDecksing

FN1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of FN1
	R&D Systems Antibodies for FN1 (Fibronectin)
	OriGene Antibodies (see all 2): FN1 OriGene Custom Antibody Services for FN1
	GenScript Custom Superior Antibodies Services for FN1
	Novus Biologicals FN1 Antibodies
	Abcam antibodies for FN1
	Uscn Antibodies for FN1
	ThermoFisher Antibody for FN1

Assay Products for FN1:

	EMD Millipore Kits and Assays for the Analysis of FN1
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FN1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FN1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FN1 for domains About GeneDecksing

5 InterPro domains/families:

IPR000083 Fibronectin_type1

IPR003961 Fibronectin_type3

IPR013783 Ig-like_fold

IPR013806 Kringle-like

IPR000562 FN_type2_col-bd

Graphical View of Domain Structure for InterPro Entry P02751

ProtoNet protein and cluster: P02751

3 Blocks protein families:

IPB000083 Fibronectin

IPB000562 Type II fibronectin collagen-binding domain

IPB003962 Fibronectin type III repeat signature

UniProtKB/Swiss-Prot: FINC_HUMAN, P02751

Similarity: Contains 12 fibronectin type-I domains

Similarity: Contains 2 fibronectin type-II domains

Similarity: Contains 16 fibronectin type-III domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FINC_HUMAN, P02751

Function: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin.

Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape

Function: Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin,

exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and

metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling

Genatlas biochemistry entry for FN1:

fibronectin 1,plasma,cell adhesion factor,playing a role in the susceptibility to lung fibrosing alveolitis in systemic

sclerosis,overexpressed in prostate cancer cells

Summary:

FN1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Neuronal progenitor cells

miRNA Products:		miRTarBase miRNAs that target FN1: hsa-mir-200b (MIRT004009), hsa-mir-200c (MIRT003959)

		OriGene 3'-UTR Clone (see all 7): FN1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FN1
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate FN1 (see all 23):
		hsa-miR-219-1-3p hsa-miR-199b-3p hsa-miR-429 hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-1271 hsa-miR-3692 hsa-miR-511

		SwitchGear 3'UTR luciferase reporter plasmid: FN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FN1 (see all 6) OriGene shRNA RFP: FN1 OriGene siRNA: FN1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FN1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for FN1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FN1 (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FN1 (see all 7) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): FN1 (NM_054034)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FN1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FN1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FN1
		LifeMap BioReagents: cell lines associated with FN1: PureStem 7SMOO32, NCr-fac & Meso Progenitor, PureStem SK11, NCr-fac & Meso-prx Progenitor

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FN1

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002020	protease binding	--	--
GO:0005201	extracellular matrix structural constituent	NAS	--
GO:0005515	protein binding	IPI	2531657
GO:0005518	collagen binding	NAS	3024962
GO:0008201	heparin binding	NAS	10075919

FN1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for FN1: Fn1^tm2Feb Fn1^tm1Hyn Fn1^tm1Bwg Fn1^tm2Hyn Fn1^tm1Ksek Fn1^tm4Hyn
     15/18 MGI mutant phenotypes (inferred from 12 alleles) (MGI details for Fn1) (see all 18):

cardiovascular system	cellular	craniofacial	embryogenesis	growth/size
hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail
mortality/aging	muscle	nervous system	normal	other

FN1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/38 super-pathways (see all 38) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion_Integrin-mediated cell adhesion and migration

Cell adhesion_Integrin-mediated cell adhesion and migration	1.00	Cytoskeleton remodeling Fibronectin-binding integrins in cell motility	0.32
Cell adhesion Integrin-mediated cell adhesion and migration	1.00	Cytoskeleton remodeling_Fibronectin-binding integrins in cell motility	0.32
Cytoskeleton remodeling_Integrin outside-in signaling	0.37	Cell adhesion_Endothelial cell contacts by non-junctional mechanisms	0.21
Cytoskeleton remodeling Integrin outside-in signaling	0.37	Cell adhesion Endothelial cell contacts by non-junctional mechanisms	0.21

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56	Inhibition of Angiogenesis by TSP1	0.37

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Cell adhesion_ECM remodeling

	Cell adhesion ECM remodeling	1.00			Metalloproteases in connective tissue degradation	0.31
	Cell adhesion_ECM remodeling	1.00

Cell adhesion_Integrin inside-out signaling

Cell adhesion_Integrin inside-out signaling

1.00

Cell adhesion Integrin inside-out signaling

0.99

Pathway sources
See GeneCards unified pathways
Show all pathways

5/12 EMD Millipore Pathways for FN1 (see all 12)

	Cytoskeleton remodeling Integrin outside-in signaling
	Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
	Cytoskeleton remodeling FAK signaling
	Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways
	Cell adhesion Plasmin signaling

1 R&D Systems Pathway for FN1

Articular Cartilage Extracellular Matrix

5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FN1 (see all 14)

	MAPK Signaling
	Molecular Mechanisms of Cancer
	PTEN Pathway
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway

5/11 GeneGo (Thomson Reuters) Pathways for FN1 (see all 11)

	Cell adhesion Integrin inside-out signaling
	Immune response TLR signaling pathways
	Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
	Cell adhesion Endothelial cell contacts by non-junctional mechanisms
	Development VEGF-family signaling

5/10 BioSystems Pathways for FN1 (see all 10)

	Senescence and Autophagy
	Focal Adhesion
	Regulation of Actin Cytoskeleton
	Angiopoietin receptor Tie2-mediated signaling
	Integrins in angiogenesis

5/16 Reactome Pathways for FN1 (see all 16)

	FN1 aggregation
	Elastic fibre formation
	Response to elevated platelet cytosolic Ca2+
	GRB2:SOS provides linkage to MAPK signaling for Intergrins
	Molecules associated with elastic fibres

5/7 Kegg Pathways (Kegg details for FN1) (see all 7):

	Focal adhesion
	ECM-receptor interaction
	Regulation of actin cytoskeleton
	Bacterial invasion of epithelial cells
	Amoebiasis

FN1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FN1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/205 Interacting proteins for FN1 (P02751^{2, 3} ENSP00000346839⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 205)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CD79A	P11912²^,³, ENSP00000221972⁴	MINT-6491150 I2D: score=1 STRING: ENSP00000221972
CTGF	P29279²^,³, ENSP00000356954⁴	MINT-1781150 MINT-1780780 MINT-1779933 MINT-1781181 MINT-1781130 I2D: score=1 STRING: ENSP00000356954
SCGB1A1	P11684²^,³, ENSP00000278282⁴	MINT-6491137 MINT-6491129 MINT-6491111 I2D: score=2 STRING: ENSP00000278282
VHL	P40337²^,³, ENSP00000256474⁴	MINT-6543105 MINT-6542668 I2D: score=5 STRING: ENSP00000256474
ITGA5	P08648²^,³, ENSP00000293379⁴	MINT-1781205 I2D: score=5 STRING: ENSP00000293379

About this table

Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0002576	platelet degranulation	TAS	--
GO:0006953	acute-phase response	IEA	--
GO:0007044	cell-substrate junction assembly	IEA	--
GO:0007155	cell adhesion	NAS	1423622

FN1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FN1 for compounds About GeneDecksing

EMD Millipore small molecules for FN1:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FN1

2 HMDB Compounds for FN1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Aldosterone	(+)-Aldosterone (see all 22)	52-39-1	16876110
Heparin	Arteven (see all 17)	9005-49-6	--

10/119 Novoseek chemical compound relationships for FN1 gene (see all 119) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
grgdsp	73.7	11	1701798 (1), 15625681 (1), 8929455 (1), 7515098 (1) (see all 7)
grgds	64.6	16	15480781 (5), 1612122 (1), 12619935 (1), 10471033 (1) (see all 7)
grgesp	61.2	5	7544537 (1), 7515098 (1), 7563001 (1)
fibronectins	59	5	9502075 (2), 8635499 (1)
fibrinogen	56.3	194	8905624 (7), 9721590 (5), 9613806 (5), 1717474 (4) (see all 61)
rgd peptide	56.3	3	8260708 (1), 9013333 (1)
ag957	55.5	2	9823945 (1), 11480565 (1)
tgf beta1	48.3	29	19565476 (6), 17347580 (5), 11887862 (3), 16686283 (3) (see all 11)
dimethyldichlorosilane	46	1	10571906 (1)
heparin	43.5	109	1688801 (4), 16622186 (4), 10992473 (3), 1607927 (3) (see all 41)

Search CenterWatch for drugs/clinical trials and news about FN1 / FINC

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FN1 gene (7 alternative transcripts):

NM_002026.2 NM_054034.2 NM_212474.1 NM_212476.1 NM_212478.1 NM_212482.1 NM_212475.1

Unigene Cluster for FN1:

Fibronectin 1

Hs.203717 [show with all ESTs]

Unigene Representative Sequence: NM_212482

18/30 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):

ENST00000421182 ENST00000323926(uc002vfi.3 uc002vfj.3) ENST00000336916(uc002vfc.3 uc002vfe.3 uc002vff.3 uc002vfb.3)

ENST00000357867(uc002vfh.3) ENST00000354785(uc010zjp.2 uc002vfa.3 uc002vfg.3)

ENST00000492816(uc002vez.3) ENST00000446046 ENST00000443816 ENST00000432072

ENST00000498719 ENST00000356005 ENST00000456923(uc010fvd.1) ENST00000494446

ENST00000469569 ENST00000473614 ENST00000480024 ENST00000461974 ENST00000485567

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FN1
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate FN1 (see all 23):
		hsa-miR-219-1-3p hsa-miR-199b-3p hsa-miR-429 hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-1271 hsa-miR-3692 hsa-miR-511

		SwitchGear 3'UTR luciferase reporter plasmid: FN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FN1 (see all 6) OriGene shRNA RFP: FN1 OriGene siRNA: FN1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FN1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FN1 (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FN1 (see all 7) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): FN1 (NM_054034)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FN1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FN1

Additional cDNA sequence:

AB191261.1 AB209287.1 AB209840.1 AF312399.1 AJ276395.1 AJ320525.1 AJ320526.1 AJ320527.1

AJ535086.1 AJ849445.1 AK026737.1 AK094153.1 AK094277.1 AK297733.1 AK300216.1 AK300246.1

AK300458.1 AK316350.1 AL832202.1 AL832771.1 AY450391.1 BC005858.2 BC016875.2 BC078656.1

BC100030.1 BC117176.1 BC143754.1 BC143763.1 BT006856.1 BX537590.1 BX538017.1 BX538018.1

BX538045.1 BX640608.1 BX640638.1 BX640731.1 BX640802.1 BX640803.1 BX640875.1 BX640920.1

BX640999.1 BX649182.1 CR749281.1 CR749316.1 CR749317.1 CR749666.1 CR936623.1 EF550130.1

EF550131.1 EF550132.1 EF550133.1 EF550134.1 EF550135.1 M10905.1 M27589.1 M27590.1

U41724.1 U41850.1 U42404.1 U42455.1 U42456.1 U42457.1 U42458.1 U42592.1

U42593.1 U42594.1 U60067.1 U60068.1 X02761.1

24/168 DOTS entries (see all 168):

DT.100713754 DT.95155416 DT.95155376 DT.95228807 DT.100049467 DT.87077684 DT.100869613 DT.91874185

DT.101987447 DT.100713740 DT.100713757 DT.100713756 DT.92377155 DT.100713727 DT.100713758 DT.95098238

DT.95079938 DT.100713783 DT.100713746 DT.92476195 DT.92412233 DT.95155519 DT.100713781 DT.91804107

24/2170 AceView cDNA sequences (see all 2170):

AW498688 BI870576 BU617195 BP346441 BU616330 CA415086 BP345466 BM887662

BQ045024 BQ183057 NM_002026 BQ181941 CN481412 BQ026822 CN483914 BU625738

AA564348 AL548168 AA449862 BQ181021 CA411722 CN480374 AA374771 BP346206

GeneLoc Exon Structure

5/19 Alternative Splicing Database (ASD) splice patterns (SP) for FN1 (see all 19) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14a	·	14b	^	15	^	16a	·	16b	^	17	^	18	^	19	^	20	^	21	^	22	^
SP1:																													-
SP2:																													-
SP3:																													-
SP4:																													-
SP5:																													-

ExUns:	23	^	24a	·	24b	^	25	^	26	^	27	^	28	^	29	^	30a	·	30b	^	31	^	32a	·	32b	^	33a	·	33b	^	34a	·	34b	·	34c	^	35	^	36	^	37a	·	37b	^	38	^	39	^	40	^	41a	·
SP1:																	-								-		-				-																				-
SP2:							-										-								-		-				-																				-
SP3:																	-								-		-				-																				-
SP4:							-										-								-		-				-																				-
SP5:							-										-								-		-		-		-																				-

ExUns:	41b	·	41c	^	42a	·	42b	^	43a	·	43b	·	43c	·	43d	^	44a	·	44b	^	45a	·	45b	·	45c	^	46a	·	46b	^	47a	·	47b	^	48a	·	48b
SP1:									-										-		-		-						-		-
SP2:									-										-		-		-						-		-
SP3:									-										-		-		-						-		-
SP4:	-								-										-		-		-						-		-
SP5:									-										-		-		-						-		-

ECgene alternative splicing isoforms for FN1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCTTGTTAC

About this image

FN1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/48 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 48)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Epicardium

Axial Tendons and Ligamnets

Tenocytes

Tendons & Ligaments

Limb Tendons and Ligamnets

Tenocytes

Tendons & Ligaments

Bone

Autopod Epiphyseal End

Prechondrocytes

Bone, Cartilage

Bone

Stylopod Epiphyseal End

Prechondrocytes

Bone, Cartilage

Bone

Zeugopod Epiphyseal End

Bone, Cartilage

Bone, Cartilage

Endochondral Osteocytes

Bone

Autopod Periosteum

Immature Endochondral Osteoblasts

Bone

Caudal Endochondral Bones

Endochondral Osteoblasts

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

mK4 (Cell line)

Kidney

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Connective tissue progenitor cells (Generation of connec...)

HyStem+TGF?3+GDF5-induced SK11 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

HyStem+TGF?3+GDF5-induced 4D20.8 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

See FN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FN1

SOURCE GeneReport for Unigene cluster: Hs.203717

UniProtKB/Swiss-Prot: FINC_HUMAN, P02751

Tissue specificity: Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked

multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular

matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine

SABiosciences Expression via Pathway-Focused PCR Arrays including FN1 (see all 17):

Parkinson's Disease in human mouse rat

Extracellular Matrix & Adhesion Molecules in human mouse rat

Multiple Sclerosis in human mouse rat

Endothelial Cell Biology in human mouse rat

WNT Signaling Targets in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FN1 Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FN1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FN1 gene from 6/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FN1¹	fibronectin 1	77.89(n) 82.36(a)		396133 NM_001198712.1 NP_001185641.1
lizard (Anolis carolinensis)	Reptilia	FN1⁶	--	78(a)	1 ↔ 1	1(116843692-116943691)
African clawed frog (Xenopus laevis)	Amphibia	fibronectin²	fibronectin protein	76.56(n)		M77820.1
zebrafish (Danio rerio)	Actinopterygii	fn1²	fibronectin 1	73.7(n)		58034 AF081128.1
fruit fly (Drosophila melanogaster)	Insecta	CG7668⁶ CG8642⁶	--	8(a) 10(a)	1 ↔ 1 possible ortholog	3L(19995836-19997934) 2R(4499189-4501660)
worm (Caenorhabditis elegans)	Secernentea	C49C8.5⁶ Y43C5A.2⁶ (see all 3)	Protein Y43C5A.2 (see all 3)	9(a) 11(a) (see all 3)	possible ortholog possible ortholog (see all 3)	IV(8648652-8653664) IV(10269859-10272676)

ENSEMBL Gene Tree for FN1 (if available)
TreeFam Gene Tree for FN1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FN1 gene

TNR² FIBCD1² FCN3² FCN1² FCN2² TNXB² TNN² MFAP4²

TNC² ANGPTL5²

8 SIMAP similar genes for FN1 using alignment to 21 protein entries: FINC_HUMAN (see all proteins):

DKFZp686B18150 DKFZp686K139 DKFZp686I1370 DKFZp686O12165 DKFZp686L11144 DKFZp686O13149

BSPH1 TNN

FN1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77078919^1,2		--	208082247(+)	`AGGCAA/CTCTCT`	5	--	ut3¹		1		NA	120
rs73089347^1,2	C,F,	--	208082249(+)	`GCAATC/GTCTTT`	5	--	ut3¹		3		WA	122
rs1264^1,2	C,F,A,	--	208082384(+)	`ATATTG/TGGGTC`	5	--	ut3¹ ese³		7		MN NA WA	430
rs73089349^1,2	C,F,	--	208082424(+)	`AAGCTG/ATCTCC`	5	--	ut3¹		2		WA	4
rs6782^1,2	C,F,	--	208082758(-)	`AAAAAA/GTTGTA`	5	--	ut3¹		5		WA NA CSA	125
rs141470685^1,2	C,	--	208083180(+)	`AAGCTA/GGAGAA`	5	--	ut3¹		0	--	--	--	--
rs55953250^1,2	C	--	208083617(+)	`AGTTG-/TTTTTT`	5	--	int¹		0	--	--	--	--
rs73987859^1,2	C,	--	208083985(+)	`TTCATG/ACATTT`	5	--	int¹		2		WA	120
rs114284140^1,2	C,F,	--	208084165(+)	`GAAAAG/AGTTTT`	5	--	int¹		1		WA	118
rs74716589^1,2	C,	--	208084218(+)	`AAGAAA/GCGTTC`	5	--	int¹		3		WA NA	240

HapMap Linkage Disequilibrium report for FN1 (216225163 - 216300895 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FN1
2 CNVs: 3406 7246
Human Gene Mutation Database (HGMD): FN1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FN1

DNA2.0 Custom Variant and Variant Library Synthesis for FN1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FN1 for disorders           About GeneDecksing

OMIM gene information: 135600
OMIM disorders: 601894
UniProtKB/Swiss-Prot: FINC_HUMAN, P02751

Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:601894]; also

known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically

heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and

hypertension that leads to end-stage renal failure in the second to fifth decade of life

20/185 diseases for FN1 (see all 185): About MalaCards

ehlers-danlos syndrome disseminated intravascular coagulation sturge-weber syndrome glomerulopathy with fibronectin deposits 2

glanzmann's thrombasthenia pre-eclampsia end stage renal failure hypersensitivity reaction type ii disease

severe pre-eclampsia vitreous detachment arterial tortuosity syndrome myocardial infarction

weber syndrome acute myocardial infarction familial combined hyperlipidemia thrombasthenia

diabetic angiopathy bacterial vaginosis waardenburg's syndrome secondary syphilis

20/28 diseases from the University of Copenhagen DISEASES database for FN1 (see all 28):

Kidney disease Lung disease Proliferative vitreoretinopathy Endocarditis

Carcinoma Ureteral disease Melanoma Hypertension

Arthritis Bacterial vaginosis Diabetes mellitus Hypersensitivity reaction type II disease

Malignant glioma Connective tissue disease Skin disease Breast cancer

Glaucoma Periodontal disease Liver disease Atherosclerosis

10/95 Novoseek disease relationships for FN1 gene (see all 95) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fibrosarcoma	37.8	16	17575686 (2), 7867715 (1), 12225805 (1), 17187346 (1) (see all 11)
tumors	37.1	159	1612776 (4), 10656615 (4), 1512857 (3), 8394677 (3) (see all 99)
ehlers-danlos syndrome	34.8	6	10651716 (1), 18405669 (1), 15054833 (1), 8186768 (1) (see all 5)
myeloma	34.6	17	7947265 (3), 10980607 (3), 9803879 (2), 8260708 (1) (see all 10)
vitreoretinopathy proliferative	34.5	4	7956309 (1), 11864408 (1), 7514582 (1)
malignant ascites	33.8	1	9428492 (1)
nephropathy iga	33.5	9	2198363 (3), 12200800 (1), 8022108 (1), 10374298 (1) (see all 6)
inflammation	31.7	42	11332203 (3), 15193149 (3), 10365576 (3), 1942612 (1) (see all 29)
metastasis	30.5	43	16148991 (4), 20359090 (3), 10072172 (3), 11244970 (3) (see all 25)
renal fibrosis	29.6	2	19229829 (1)

Genetic Association Database (GAD): FN1
Human Genome Epidemiology (HuGE) Navigator: FN1 (20 documents)

Export disorders for FN1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FN1 gene, integrated from 9 sources (see all 1341):
(articles sorted by number of sources associating them with FN1)

Utopia: connect your pdf to the dynamic
world of online information

Evolution of the fibronectin gene. Exon structure of cell attachment domain. (PubMed id 3003095)^{1, 2, 3} Oldberg A. and Ruoslahti E. (1986)
Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene. (PubMed id 2992939)^{1, 2, 3} Kornblihtt A.R.... Baralle F.E. (1985)
Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of fibronectin. (PubMed id 1400330)^{1, 2, 9} Balbona K....Argraves W.S. (1992)
Mutations in FN1 cause glomerulopathy with fibronectin deposits. (PubMed id 18268355)^{1, 2, 9} Castelletti F.... Noris M. (2008)
Phenotypic and genetic alterations in mammary stroma: implications for tumour progression. (PubMed id 11737888)^{1, 2, 9} Schor S.L. and Schor A.M. (2001)
Crystal structure of a heparin- and integrin-binding segment of human fibronectin. (PubMed id 10075919)^{1, 2, 9} Sharma A.... Stuart D.I. (1999)
Identification and structural analysis of type I collagen sites in complex with fibronectin fragments. (PubMed id 19251642)^{1, 2} Erat M.C.... Vakonakis I. (2009)
Crystal structures of fibronectin-binding sites from Staphylococcus aureus FnBPA in complex with fibronectin domains. (PubMed id 18713862)^{1, 2} Bingham R.J....Potts J.R. (2008)
A novel role for fibronectin type I domain in the regulation of human hematopoietic cell adhesiveness through binding to follistatin domains of FLRG and follistatin. (PubMed id 16336961)^{1, 2} Maguer-Satta V....Rimokh R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2335	HGNC: 3778	AceView: FN1	Ensembl:ENSG00000115414	euGenes: HUgn2335
ECgene: FN1	Kegg: 2335	H-InvDB: FN1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FN1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FN1	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Fibronectin

Intellectual Property for FN1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FN1 gene:
Search GeneIP for patents involving FN1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

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fibronectin 1

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Nephritis
Myelofibrosis
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LUNG CARCINOMA
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cell damage
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GLOMERULONEPHRITIS MESANGIAL PROLIFERATIVE
Disseminated Intravascular Coagulation
Collagen fibril
Preeclampsia
Gingival Hyperplasia
Myeloid Leukemia
Melanoma
Autoimmune Diseases
bladder cancer
Colon Cancer
Critically Ill
HEMATURIA MICROSCOPIC
Vasculitis
Glioma
Chronic glomerulonephritis
Liver Fibrosis
Diabetic Angiopathies
Carcinoma
Osteoarthritis
INFARCT
Myeloid Leukemia Chronic
Leukemia
Alzheimers Disease
Renal fibrosis
Heart Failure Congestive
HEPATOCELLULAR CARCINOMA
Calcification
THYROID PAPILLARY CARCINOMA
metastatic melanoma
Epiretinal Membrane
Papilloma Intraductal
Hypersensitivity Delayed
Myocardial Infarction
Coronary Artery Disease
MENINGEAL CARCINOMATOSIS
HIV Infections
Bleeding
OVARIAN CARCINOMA
Carcinoma Squamous Cell
Carcinoma Intraductal
Glanzmann Thrombasthenia
Chromosomal Aberrations
plasma cell myeloma
Lupus Nephritis
liver metastases
Glomerulonephritis

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FN1 Gene

fibronectin 1

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Aliases
for FN1 gene

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for FN1 gene

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for FN1 gene

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for FN1 gene

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Families
for FN1 gene

Function
for FN1 gene

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for FN1 gene

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for FN1 gene

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for FN1 gene

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for FN1 gene

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for FN1 gene

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for FN1 gene

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for FN1 gene

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for FN1 gene

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for FN1 gene

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for FN1 gene

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for FN1 gene