Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FN1 Gene

protein-coding   GIFtS: 72
GCID: GC02M216225

Fibronectin 1

  See FN1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Fibronectin 11 2     LETS2 5
Cold-Insoluble Globulin1 2 3     ED-B2
FN2 3 5     FINC2
Migration-Stimulating Factor1 2     GFND2
CIG2 3     MSF2
FNZ2 5     fibronectin2
GFND22 5     

External Ids:    HGNC: 37781   Entrez Gene: 23352   Ensembl: ENSG000001154147   OMIM: 1356005   UniProtKB: P027513   

Export aliases for FN1 gene to outside databases

Previous GC identifers: GC02M214388 GC02M214950 GC02M216189 GC02M216428 GC02M216050 GC02M215933 GC02M208082


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FN1 Gene:
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or
multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and
migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The
gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript
variants. However, the full-length nature of some variants has not been determined. (provided by RefSeq, Jul
2008)

GeneCards Summary for FN1 Gene:
FN1 (fibronectin 1) is a protein-coding gene. Diseases associated with FN1 include glomerulopathy with fibronectin deposits 2, and plasma fibronectin deficiency. GO annotations related to this gene include heparin binding and collagen binding. An important paralog of this gene is TNXB.

UniProtKB/Swiss-Prot: FINC_HUMAN, P02751
Function: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and
actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of
cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix
assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen
deposition by osteoblasts
Function: Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named
superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor
growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling

Gene Wiki entry for FN1 (Fibronectin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FN1 gene promoter:
         AP-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): FN1 promoter sequence
   Search Chromatin IP Primers for FN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q34   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q34

FN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FN1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M216225:  view genomic region     (about GC identifiers)

Start:
216,225,163 bp from pter      End:
216,300,895 bp from pter
Size:
75,733 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FINC_HUMAN, P02751 (See protein sequence)
Recommended Name: Fibronectin precursor  
Size: 2386 amino acids; 262625 Da
Subunit: Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near
the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1.
Interacts with FBLN7 (By similarity). Interacts with COMP. Interacts with S.aureus fnbA. Interacts with TNR; the
interaction inhibits cell adhesion and neurite outgrowth (By similarity). Interacts with FST3
Developmental stage: Ugl-Y1, Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age
Sequence caution: Sequence=AAX76513.1; Type=Erroneous gene model prediction; Sequence=BAD93077.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened; Sequence=CAD91166.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened; Sequence=CAD97964.1; Type=Erroneous initiation; Note=Translation
N-terminally shortened; Sequence=CAD97965.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAH18136.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Selected PDB 3D structures from and Proteopedia for FN1 (see all 40):
1E88 (3D)        1E8B (3D)        1FBR (3D)        1FNA (3D)        1FNF (3D)        1FNH (3D)    
Secondary accessions: B7ZLF0 E9PE77 E9PG29 O95609 O95610 Q14312 Q14325 Q14326 Q17RV7 Q564H7
Q585T2 Q59EH1 Q60FE4 Q68DP8 Q68DP9 Q68DT4 Q6LDP6 Q6MZS0 Q6MZU5 Q6N025 Q6N0A6 Q86T27 Q8IVI8
Q96KP7 Q96KP8 Q96KP9 Q9H1B8 Q9HAP3 Q9UMK2
Alternative splicing: 17 isoforms:  P02751-1   P02751-2   P02751-3   P02751-4   P02751-5   P02751-6   P02751-7   P02751-8   
P02751-9   P02751-10   P02751-11   P02751-12   P02751-13   P02751-14   P02751-15   P02751-16   
P02751-17   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for FN1: NX_P02751

Explore proteomics data for FN1 at MOPED

Post-translational modifications: 

  • Sulfated1
  • It is not known whether both or only one of Thr-2064 and Thr-2065 are/is glycosylated1
  • Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the
    epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin,
    collagen-fibronectin heteropolymers)1
  • Phosphorylation sites are present in the extracellular medium1
  • Proteolytic processing produces the C-terminal NC1 peptide, anastellin1
  • Ubiquitination2 at Lys1050
  • Glycosylation2 at Thr278, Thr279, Ser280, Ser281, Ser283, Thr287, Asn430, Asn528, Asn542, Asn877,
                                 Asn1007, Asn1244, Thr1276, Ser1565, Ser1566, Ser1567, Thr1570, Thr1641, Thr1999, Thr2060 (see all 29)
  • Modification sites at PhosphoSitePlus

  • See FN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_002017.1  NP_473375.2  NP_997639.1  NP_997641.1  NP_997643.1  NP_997647.1  

    ENSEMBL proteins: 
     ENSP00000394423   ENSP00000323534   ENSP00000338200   ENSP00000350534   ENSP00000346839  
     ENSP00000410422   ENSP00000415018   ENSP00000399538   ENSP00000348285   ENSP00000416139  
     ENSP00000392565   ENSP00000398907   ENSP00000352696   ENSP00000265312   ENSP00000273049  
     ENSP00000349509  
    Reactome Protein details: P02751

    FN1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant FN1 Protein
    R&D Systems Recombinant & Natural Proteins for FN1 (Fibronectin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FN1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FN1
    GenScript Custom Purified and Recombinant Proteins Services for FN1
    Novus Biologicals FN1 Proteins
    Novus Biologicals FN1 Lysates
    Sino Biological Recombinant Protein for FN1
    Sino Biological Cell Lysate for FN1
    ProSpec Recombinant Protein for FN1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for FN1 

    FN1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FN1
    R&D Systems Antibodies for FN1 (Fibronectin)
    OriGene Antibodies for FN1
    OriGene Custom Antibody Services for FN1
    Novus Biologicals FN1 Antibodies
    Abcam antibodies for FN1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for FN1
    LSBio Antibodies in human, mouse, rat for FN1

    FN1 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of FN1
    OriGene Custom Assay Services for FN1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FN1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    eBioscience ELISAs for FN1:  
                        Human Fibronectin Platinum ELISA 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    ENDOLIG: Endogenous ligands

    5 InterPro protein domains:
     IPR000083 Fibronectin_type1
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold
     IPR013806 Kringle-like
     IPR000562 FN_type2_col-bd

    Graphical View of Domain Structure for InterPro Entry P02751

    ProtoNet protein and cluster: P02751

    3 Blocks protein domains:
    IPB000083 Fibronectin
    IPB000562 Type II fibronectin collagen-binding domain
    IPB003962 Fibronectin type III repeat signature


    UniProtKB/Swiss-Prot: FINC_HUMAN, P02751
    Similarity: Contains 12 fibronectin type-I domains
    Similarity: Contains 2 fibronectin type-II domains
    Similarity: Contains 16 fibronectin type-III domains


    Find genes that share domains with FN1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FINC_HUMAN, P02751
    Function: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and
    actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of
    cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix
    assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen
    deposition by osteoblasts
    Function: Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named
    superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor
    growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling

         Genatlas biochemistry entry for FN1:
    fibronectin 1,plasma,cell adhesion factor,playing a role in the susceptibility to lung fibrosing alveolitis in
    systemic sclerosis,overexpressed in prostate cancer cells

         Summary: 
    FN1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
          selected tissues (see all 3)      
    Endothelium: Endothelial-like cells, Endothelial-like cells
    Head Mesenchyme: Melanocytes-like cells , Melanocytes-like cells

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI--
    GO:0005178integrin binding IDA19738201
    GO:0005201extracellular matrix structural constituent ----
    GO:0005515protein binding IPI10627046
    GO:0005518collagen binding NAS3024962
         
    Find genes that share ontologies with FN1           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 12 alleles(MGI details for Fn1) (see all 18):
     cardiovascular system  cellular  craniofacial  embryogenesis  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 
     mortality/aging  muscle  nervous system  normal  other 

    Find genes that share phenotypes with FN1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FN1: Fn1tm2Feb Fn1tm1Hyn Fn1tm1Bwg Fn1tm2Hyn Fn1tm1Ksek Fn1tm4Hyn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FN1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FN1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FN1

    miRNA
    Products:
        
    miRTarBase miRNAs that target FN1:
    hsa-mir-200b-3p (MIRT004009), hsa-mir-1 (MIRT006132), hsa-mir-200c-3p (MIRT003959), hsa-mir-26b-5p (MIRT029079), hsa-mir-615-3p (MIRT040254)

    Block miRNA regulation of human, mouse, rat FN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FN1 (see all 23):
    hsa-miR-219-1-3p hsa-miR-199b-3p hsa-miR-429 hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-1271 hsa-miR-3692 hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmidFN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FN1
    Predesigned siRNA for gene silencing in human, mouse, rat FN1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FN1

    Clone
    Products:
         
    OriGene clones in human, mouse for FN1 (see all 29)
    OriGene ORF clones in mouse, rat for FN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): FN1 (NM_054034)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FN1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FN1
    ESI BIO PureStem Progenitors for FN1: 
    PureStem 7SMOO32, NCr-fac & Meso Progenitor, PureStem SK11, NCr-fac & Meso-prx Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FN1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA6-11243) for FN1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FINC_HUMAN, P02751: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton4
    plasma membrane3
    endoplasmic reticulum2
    golgi apparatus2
    mitochondrion2
    nucleus2
    cytosol1
    endosome1
    lysosome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005577fibrinogen complex IDA3997886
    GO:0005578proteinaceous extracellular matrix ----
    GO:0005604basement membrane IEA--
    GO:0005615extracellular space IDA--

    Find genes that share ontologies with FN1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FN1 About   (see all 37)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    ECM-receptor interaction0.31
    Focal Adhesion0.65
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    3Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31
    Cell adhesion ECM remodeling0.31
    4VEGFR3 signaling in lymphatic endothelium
    VEGFR3 signaling in lymphatic endothelium
    Fibronectin matrix formation0.00
    5Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38


    Find genes that share SuperPaths with FN1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for FN1
        Articular Cartilage Extracellular Matrix

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FN1 (see all 14)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway

    Selected GeneGo (Thomson Reuters) Pathways for FN1 (see all 11)
        Cell adhesion Integrin inside-out signaling
    Immune response TLR signaling pathways
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Development VEGF-family signaling

    Selected BioSystems Pathways for FN1 (see all 10)
        Focal Adhesion
    Senescence and Autophagy
    Regulation of Actin Cytoskeleton
    Integrins in angiogenesis
    amb2 Integrin signaling


    Selected Reactome Pathways for FN1 (see all 13)
        Integrin cell surface interactions
    p130Cas linkage to MAPK signaling for integrins
    GRB2:SOS provides linkage to MAPK signaling for Integrins
    ECM proteoglycans
    Molecules associated with elastic fibres


    Selected Kegg Pathways  (Kegg details for FN1) (see all 9):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Regulation of actin cytoskeleton
    Bacterial invasion of epithelial cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FN1 (see all 17): 
              Parkinson's Disease in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Multiple Sclerosis in human mouse rat
              Endothelial Cell Biology in human mouse rat
              WNT Signaling Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FN1 (P027511, 2, 3 ENSP000003468394) via UniProtKB, MINT, STRING, and/or I2D (see all 210)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    fnbBQ536821, 2EBI-1220319,EBI-8398005 MINT-7991577 MINT-8173367 MINT-8173347 MINT-7991114 MINT-8173300 MINT-7991177 MINT-7991390 MINT-7991103 MINT-7991165 MINT-7991321 MINT-7991153 MINT-7991345 MINT-7991405 MINT-7991375 MINT-7991594 MINT-7991138 MINT-7991420 MINT-7991360 MINT-7991126
    fnbAP147381, 2EBI-1220319,EBI-8398157 MINT-7991507 MINT-7991522 MINT-7991462 MINT-7991253 MINT-7991447 MINT-7991227 MINT-7991477 MINT-7991558 MINT-7991636 MINT-7991292 MINT-7991435 MINT-7991540 MINT-7991266 MINT-7991622 MINT-7991189 MINT-7991305 MINT-7991492 MINT-7991279
    CTGFP292791, 2, 3, ENSP000003569544EBI-1220319,EBI-2835375 MINT-1781150 MINT-1780780 MINT-1779933 MINT-1781181 MINT-1781130 I2D: score=1 STRING: ENSP00000356954
    ITGB1P055562, 3, ENSP000003640944MINT-8208428 I2D: score=2 STRING: ENSP00000364094
    CD79AP119122, 3, ENSP000002219724MINT-6491150 I2D: score=1 STRING: ENSP00000221972
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0002576platelet degranulation TAS--
    GO:0006953acute-phase response IEA--
    GO:0007044cell-substrate junction assembly IEA--
    GO:0007155cell adhesion NAS1423622

    Find genes that share ontologies with FN1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FN1 (FINC)

    2 HMDB Compounds for FN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Aldosterone(+)-Aldosterone (see all 22)52-39-116876110
    HeparinArteven (see all 17)9005-49-6--

    1 DrugBank Compound for FN1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Ocriplasmin -- 1048016-9-6targetcleavage23193358

    Selected Novoseek inferred chemical compound relationships for FN1 gene (see all 119)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    grgdsp 73.7 11 1701798 (1), 15625681 (1), 8929455 (1), 7515098 (1) (see all 7)
    grgds 64.6 16 15480781 (5), 1612122 (1), 12619935 (1), 10471033 (1) (see all 7)
    grgesp 61.2 5 7544537 (1), 7515098 (1), 7563001 (1)
    fibronectins 59 5 9502075 (2), 8635499 (1)
    fibrinogen 56.3 194 8905624 (7), 9721590 (5), 9613806 (5), 1717474 (4) (see all 61)
    rgd peptide 56.3 3 8260708 (1), 9013333 (1)
    ag957 55.5 2 9823945 (1), 11480565 (1)
    tgf beta1 48.3 29 19565476 (6), 17347580 (5), 11887862 (3), 16686283 (3) (see all 11)
    dimethyldichlorosilane 46 1 10571906 (1)
    heparin 43.5 109 1688801 (4), 16622186 (4), 10992473 (3), 1607927 (3) (see all 41)



    Find genes that share compounds with FN1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FN1 gene (7 alternative transcripts): 
    NM_002026.2  NM_054034.2  NM_212474.1  NM_212476.1  NM_212478.1  NM_212482.1  NM_212475.1  

    Unigene Cluster for FN1:

    Fibronectin 1
    Hs.203717  [show with all ESTs]
    Unigene Representative Sequence: NM_212482
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000421182 ENST00000323926(uc002vfi.3 uc002vfj.3) ENST00000336916(uc002vfc.3 uc002vfe.3 uc002vff.3 uc002vfb.3)
    ENST00000357867(uc002vfh.3) ENST00000354785(uc010zjp.2 uc002vfa.3 uc002vfg.3)
    ENST00000492816(uc002vez.3) ENST00000446046 ENST00000443816 ENST00000432072
    ENST00000498719 ENST00000356005 ENST00000456923(uc010fvd.1) ENST00000494446
    ENST00000469569 ENST00000473614 ENST00000480024 ENST00000461974 ENST00000485567

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FN1 (see all 23):
    hsa-miR-219-1-3p hsa-miR-199b-3p hsa-miR-429 hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-1271 hsa-miR-3692 hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmidFN1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FN1
    Predesigned siRNA for gene silencing in human, mouse, rat FN1
    Clone
    Products:
         
    OriGene clones in human, mouse for FN1 (see all 29)
    OriGene ORF clones in mouse, rat for FN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): FN1 (NM_054034)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FN1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FN1
      QuantiTect SYBR Green Assays in human, mouse, rat FN1
      QuantiFast Probe-based Assays in human, mouse, rat FN1
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA6-11243) for FN1 

    Additional mRNA sequence: 

    AB191261.1 AB209287.1 AB209840.1 AF312399.1 AJ276395.1 AJ320525.1 AJ320526.1 AJ320527.1 
    AJ535086.1 AJ849445.1 AK026737.1 AK094153.1 AK094277.1 AK297733.1 AK300216.1 AK300246.1 
    AK300458.1 AK316350.1 AL832202.1 AL832771.1 AY450391.1 BC005858.2 BC016875.2 BC078656.1 
    BC100030.1 BC117176.1 BC143754.1 BC143763.1 BT006856.1 BX537590.1 BX538017.1 BX538018.1 
    BX538045.1 BX640608.1 BX640638.1 BX640731.1 BX640802.1 BX640803.1 BX640875.1 BX640920.1 
    BX640999.1 BX649182.1 CR749281.1 CR749316.1 CR749317.1 CR749666.1 CR936623.1 EF550130.1 
    EF550131.1 EF550132.1 EF550133.1 EF550134.1 EF550135.1 M10905.1 M27589.1 M27590.1 
    U41724.1 U41850.1 U42404.1 U42455.1 U42456.1 U42457.1 U42458.1 U42592.1 
    U42593.1 U42594.1 U60067.1 U60068.1 X02761.1 

    Selected DOTS entries (see all 166):

    DT.100713754  DT.95155416  DT.95155376  DT.95228807  DT.100049467  DT.87077684  DT.100869613  DT.91874185 
    DT.101987447  DT.100713740  DT.100713757  DT.100713756  DT.92377155  DT.100713727  DT.100713758  DT.95098238 
    DT.95079938  DT.100713783  DT.100713746  DT.92476195  DT.92412233  DT.95155519  DT.100713781  DT.91804107 

    Selected AceView cDNA sequences (see all 2170):

    BU626307 AI755147 BQ180911 CN482442 AI755100 AA295522 CA428131 BM997017 
    AA670055 BQ183617 CA421021 CN479689 AA304632 CA413792 CA414780 AU140688 
    AL701644 BU677644 NM_002026 BF987968 CA412458 AW069283 AW662115 BX472804 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FN1 (see all 19)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                                                                                      -                                                                     
    SP2:                                                                                      -                                                                     
    SP3:                                                                                      -                                                                     
    SP4:                                                                                      -                                                                     
    SP5:                                                                                      -                                                                     

    ExUns: 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b ^ 33a · 33b ^ 34a · 34b · 34c ^ 35 ^ 36 ^ 37a · 37b ^ 38 ^ 39 ^ 40 ^ 41a ·
    SP1:                                                  -                       -     -           -                                                           -   
    SP2:                    -                             -                       -     -           -                                                           -   
    SP3:                                                  -                       -     -           -                                                           -   
    SP4:                    -                             -                       -     -           -                                                           -   
    SP5:                    -                             -                       -     -     -     -                                                           -   

    ExUns: 41b · 41c ^ 42a · 42b ^ 43a · 43b · 43c · 43d ^ 44a · 44b ^ 45a · 45b · 45c ^ 46a · 46b ^ 47a · 47b ^ 48a · 48b
    SP1:                          -                             -     -     -                 -     -                     
    SP2:                          -                             -     -     -                 -     -                     
    SP3:                          -                             -     -     -                 -     -                     
    SP4:  -                       -                             -     -     -                 -     -                     
    SP5:                          -                             -     -     -                 -     -                     


    ECgene alternative splicing isoforms for FN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCTTGTTAC
    FN1 Expression
    About this image


    FN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 36) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 27 entries
             Prechondrocytes Autopod Epiphyseal End
             Notch-transfected mesenchymal stromal cells (SB623)
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 6 entries
             Prechondrocytes Autopod Epiphyseal End
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Tendon & Ligament (Muscoskeletal System)    fully expand to see all 2 entries
             Tenocytes Axial Tendons and Ligamnets
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Subepicardial Cells Epicardium
     
     Tooth (Integumentary System)    fully expand to see all 5 entries
             Dental Papilla Cells Dental Papilla
             Dentin
             Stem cells from human exfoliated deciduous teeth (family)
    FN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.203717

    UniProtKB/Swiss-Prot: FINC_HUMAN, P02751
    Tissue specificity: Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or
    cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in
    the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FN1 (see all 17): 
              Parkinson's Disease in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Multiple Sclerosis in human mouse rat
              Endothelial Cell Biology in human mouse rat
              WNT Signaling Targets in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FN1
    QuantiTect SYBR Green Assays in human, mouse, rat FN1
    QuantiFast Probe-based Assays in human, mouse, rat FN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for FN1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fn11 , 5 fibronectin 11, 5 87.33(n)1
    91.84(a)1
      1 (36.05 cM)5
    142681  NM_010233.21  NP_034363.11 
     715855235 
    chicken
    (Gallus gallus)
    Aves FN11 fibronectin 1 77.72(n)
    82(a)
      396133  NM_001198712.1  NP_001185641.1 
    lizard
    (Anolis carolinensis)
    Reptilia FN16
    fibronectin 1
    79(a)
    1 ↔ 1
    1(116842931-116943930)
    African clawed frog
    (Xenopus laevis)
    Amphibia fibronectin2 fibronectin protein 76.56(n)    M77820.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fn12 fibronectin 1 73.7(n)   58034  AF081128.1 
    worm
    (Caenorhabditis elegans)
    Secernentea D1009.36
    Protein D1009.3, isoform a (D1009.3) mRNA, complet...
    11(a)
    1 ↔ 1
    X(8908050-8910828) WBGene00017013


    ENSEMBL Gene Tree for FN1 (if available)
    TreeFam Gene Tree for FN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FN1 gene
    TNXB2  ANGPTL32  TNR2  FGA2  TNN2  ANGPTL42  ANGPTL52  TNC2  
    6 SIMAP similar genes for FN1 using alignment to 17 protein entries:     FINC_HUMAN (see all proteins):
    DKFZp686I1370    DKFZp686O12165    DKFZp686B18150    DKFZp686K139    DKFZp686L11144    DKFZp686O13149

    Find genes that share paralogs with FN1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FN1 (see all 2037)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360194
    A breast cancer sample4--see VAR_0360192 R P mis40--------
    VAR_0439184
    Glomerulopathy with fibronectin deposits 2 (GFND2)4--see VAR_0439182 Y C mis40--------
    VAR_0360204
    A colorectal cancer sample4--see VAR_0360202 D N mis40--------
    VAR_0439194
    Glomerulopathy with fibronectin deposits 2 (GFND2)4--see VAR_0439192 W R mis40--------
    VAR_0439204
    Glomerulopathy with fibronectin deposits 2 (GFND2)4--see VAR_0439202 L R mis40--------
    VAR_0360184
    A breast cancer sample4--see VAR_0360182 D N mis40--------
    rs58385011,2
    C--208086092(+) GCCATG/-GGGAC 5 -- int13Minor allele frequency- -:0.00NA CSA 6
    rs713991951,2
    C--208093219(+) GAATATCTT/-  
            
    ATCTT
    5 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs352339971,2
    C--208095981(+) TCTGCT/-TTCTA 5 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs667416171,2
    C--208098774(+) AATTTTG/-TGTGT 5 -- int11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for FN1 (216225163 - 216300895 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33472CNV Loss17666407
    dgv1288e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): FN1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FN1
    DNA2.0 Custom Variant and Variant Library Synthesis for FN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 135600   
    OMIM disorders: 601894  614101  
    UniProtKB/Swiss-Prot: FINC_HUMAN, P02751
  • Glomerulopathy with fibronectin deposits 2 (GFND2) [MIM:601894]: Genetically heterogeneous autosomal
    dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to
    end-stage renal failure in the second to fifth decade of life. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 15 diseases for FN1:    
    About MalaCards
    glomerulopathy with fibronectin deposits 2    plasma fibronectin deficiency    arterial tortuosity syndrome    mycobacterium kansasii
    cryofibrinogenemia    sturge-weber syndrome    secondary syphilis    vitreous detachment
    weber syndrome    type ii mixed cryoglobulinemia    secretory meningioma    calciphylaxis
    ureteral disease    myeloma    colorectal cancer

    Selected diseases from the University of Copenhagen DISEASES database for FN1 (see all 30):
    Kidney disease     Lung disease     Proliferative vitreoretinopathy     Ureteral disease
    Endocarditis     Carcinoma     Melanoma     Hypertension
    Bacterial vaginosis     Arthritis     Diabetes mellitus     Hypersensitivity reaction type II disease
    Connective tissue disease     Malignant glioma     Glaucoma     Skin disease
    Breast cancer     Periodontal disease     Liver disease     Atherosclerosis

    Find genes that share disorders with FN1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FN1 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrosarcoma 37.8 16 17575686 (2), 7867715 (1), 12225805 (1), 17187346 (1) (see all 11)
    tumors 37.1 159 1612776 (4), 10656615 (4), 1512857 (3), 8394677 (3) (see all 99)
    ehlers-danlos syndrome 34.8 6 10651716 (1), 18405669 (1), 15054833 (1), 8186768 (1) (see all 5)
    myeloma 34.6 17 7947265 (3), 10980607 (3), 9803879 (2), 8260708 (1) (see all 10)
    vitreoretinopathy proliferative 34.5 4 7956309 (1), 11864408 (1), 7514582 (1)
    malignant ascites 33.8 1 9428492 (1)
    nephropathy iga 33.5 9 2198363 (3), 12200800 (1), 8022108 (1), 10374298 (1) (see all 6)
    inflammation 31.7 42 11332203 (3), 15193149 (3), 10365576 (3), 1942612 (1) (see all 29)
    metastasis 30.5 43 16148991 (4), 20359090 (3), 10072172 (3), 11244970 (3) (see all 25)
    renal fibrosis 29.6 2 19229829 (1)

    Genetic Association Database (GAD): FN1
    Human Genome Epidemiology (HuGE) Navigator: FN1 (20 documents)

    Export disorders for FN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FN1 gene, integrated from 10 sources (see all 1395):
    (articles sorted by number of sources associating them with FN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evolution of the fibronectin gene. Exon structure of cell attachment domain. (PubMed id 3003095)1, 2, 3 Oldberg A. and Ruoslahti E. (J. Biol. Chem. 1986)
    2. Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene. (PubMed id 2992939)1, 2, 3 Kornblihtt A.R.... Baralle F.E. (EMBO J. 1985)
    3. The expression of migration stimulating factor, a potent oncofetal cytokine, is uniquely controlled by 3'-untranslated region-dependent nuclear sequestration of its precursor messenger RNA. (PubMed id 16322219)1, 2, 9 Kay R.A.... Schor S.L. (Cancer Res. 2005)
    4. Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of fibronectin. (PubMed id 1400330)1, 2, 9 Balbona K....Argraves W.S. (J. Biol. Chem. 1992)
    5. Mutations in FN1 cause glomerulopathy with fibronectin deposits. (PubMed id 18268355)1, 2, 9 Castelletti F.... Noris M. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    6. Phenotypic and genetic alterations in mammary stroma: implications for tumour progression. (PubMed id 11737888)1, 2, 9 Schor S.L. and Schor A.M. (Breast Cancer Res. 2001)
    7. Crystal structure of a heparin- and integrin-binding segment of human fibronectin. (PubMed id 10075919)1, 2, 9 Sharma A.... Stuart D.I. (EMBO J. 1999)
    8. A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. (PubMed id 22319020)1, 4 Davies R.W....McPherson R. (Circ Cardiovasc Genet 2012)
    9. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    10. Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate. (PubMed id 20672350)1, 4 Nikopensius T....Metspalu A. (Birth Defects Res. Part A Clin. Mol. Teratol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2335 HGNC: 3778 AceView: FN1 Ensembl:ENSG00000115414 euGenes: HUgn2335
    ECgene: FN1 Kegg: 2335 H-InvDB: FN1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FN1 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Fibronectin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FN1 gene:
    Search GeneIP for patents involving FN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Purified and/or Recombinant FN1 Protein
     EMD Millipore Kits and Assays for the Analysis of FN1
     EMD Millipore Mono- and Polyclonal Antibodies for the study of FN1
     
     EMD Millipore genomic analysis products

      
     Antibodies for FN1 (Fibronectin)   Cell Culture Products for FN1 (Fibronectin)  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for FN1 (Fibronectin)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FN1   OriGene RNAi products in human, mouse, rat for FN1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for FN1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FN1  
     OriGene qSTAR qPCR primer pairs in human, mouse for FN1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FN1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FN1   OriGene Custom Protein Services for FN1  

     
     
     Block miRNA regulation of human, mouse, rat FN1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FN1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FN1 Predesigned siRNA for gene silencing in human, mouse, rat FN1
     QuantiFast Probe-based Assays in human, mouse, rat FN1 QuantiTect SYBR Green Assays in human, mouse, rat FN1
     PCR Arrays including human, mouse, rat FN1 Search Chromatin IP Primers for FN1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FN1  GeneGlobe Interaction Network for FN1
     Regulatory tfbs in FN1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FN1 GenScript cDNA clones with any tag delivered in your preferred vector for FN1
     GenScript Custom Assay Services for FN1 GenScript Custom overexpressing Cell Line Services for FN1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FN1 (FINC)
     Proteins for FN1
     Cell Lysates for FN1
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FN1 antibodies
     FN1 proteins
     FN1 lysates
     Antibodies for FN1
     See all of Abcam's Antibodies, Kits and Proteins for FN1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for FN1
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     PureStem Progenitors for FN1: PureStem 7SMOO32, NCr-fac & Meso Progenitor, PureStem SK11, NCr-fac & Meso-prx Progenitor
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FN1
     SwitchGear 3'UTR luciferase reporter plasmids for FN1
     SwitchGear Promoter luciferase reporter plasmids for FN1
     ThermoFisher Antibody for FN1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FN1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FN1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FN1
     LSBio Antibodies in human, mouse, rat for FN1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for FN1
      Search eBioscience for proteins for FN1
     eBioscience elisas for FN1 (Human Fibronectin Platinum ELISA 96 tests)
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FN1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4