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Aliases for FN1 Gene

Aliases for FN1 Gene

  • Fibronectin 1 2 3
  • Cold-Insoluble Globulin 2 3 4
  • FN 3 4 6
  • Migration-Stimulating Factor 2 3
  • GFND2 3 6
  • LETS 3 6
  • FNZ 3 6
  • CIG 3 4
  • Fibronectin 3
  • ED-B 3
  • FINC 3
  • GFND 3
  • MSF 3

External Ids for FN1 Gene

Summaries for FN1 Gene

Entrez Gene Summary for FN1 Gene

  • This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for FN1 Gene

FN1 (Fibronectin 1) is a Protein Coding gene. Diseases associated with FN1 include glomerulopathy with fibronectin deposits 2 and plasma fibronectin deficiency. Among its related pathways are PI3K-Akt signaling pathway and Signaling by GPCR. GO annotations related to this gene include heparin binding and collagen binding. An important paralog of this gene is TNC.

UniProtKB/Swiss-Prot for FN1 Gene

  • Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts

  • Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling

Gene Wiki entry for FN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FN1 Gene

Genomics for FN1 Gene

Genomic Location for FN1 Gene

Start:
215,360,440 bp from pter
End:
215,436,172 bp from pter
Size:
75,733 bases
Orientation:
Minus strand

Genomic View for FN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FN1 Gene

Regulatory Elements for FN1 Gene

Transcription factor binding sites by QIAGEN in the FN1 gene promoter:

Proteins for FN1 Gene

  • Protein details for FN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02751-FINC_HUMAN
    Recommended name:
    Fibronectin
    Protein Accession:
    P02751
    Secondary Accessions:
    • B7ZLF0
    • E9PE77
    • E9PG29
    • O95609
    • O95610
    • Q14312
    • Q14325
    • Q14326
    • Q17RV7
    • Q564H7
    • Q585T2
    • Q59EH1
    • Q60FE4
    • Q68DP8
    • Q68DP9
    • Q68DT4
    • Q6LDP6
    • Q6MZS0
    • Q6MZU5
    • Q6N025
    • Q6N0A6
    • Q7Z391
    • Q86T27
    • Q8IVI8
    • Q96KP7
    • Q96KP8
    • Q96KP9
    • Q9H1B8
    • Q9HAP3
    • Q9UMK2

    Protein attributes for FN1 Gene

    Size:
    2386 amino acids
    Molecular mass:
    262625 Da
    Quaternary structure:
    • Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1. Interacts with FBLN7 (By similarity). Interacts with COMP. Interacts with S.aureus fnbA. Interacts with TNR; the interaction inhibits cell adhesion and neurite outgrowth (By similarity). Interacts with FST3 and MYOC.
    SequenceCaution:
    • Sequence=AAX76513.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAD93077.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD91166.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD97964.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD97965.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD97984.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH18136.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FN1 Gene

neXtProt entry for FN1 Gene

Proteomics data for FN1 Gene at MOPED

Post-translational modifications for FN1 Gene

  • Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers)
  • It is not known whether both or only one of Thr-2064 and Thr-2065 are/is glycosylated.
  • Phosphorylation sites are present in the extracellular medium
  • Proteolytic processing produces the C-terminal NC1 peptide, anastellin
  • Sulfated.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys1050
  • Glycosylation at Thr278, Thr279, Ser280, Ser281, Ser283, Thr287, Asn430, Asn528, Asn542, Asn877, Asn1007, Asn1244, Thr1276, Ser1565, Ser1566, Ser1567, Thr1570, Thr1641, Thr1999, Thr2060, Thr2061, Thr2064, Thr2065, Thr2067, Asn2108, Ser2341, Thr2345, Thr2346, and Ser2349

No data available for DME Specific Peptides for FN1 Gene

Domains for FN1 Gene

Gene Families for FN1 Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • FN3 :Fibronectin type III domain containing

UniProtKB/Swiss-Prot:

FINC_HUMAN
Domain:
  • Contains 12 fibronectin type-I domains.:
    • P02751
  • Contains 2 fibronectin type-II domains.:
    • P02751
  • Contains 16 fibronectin type-III domains.:
    • P02751
genes like me logo Genes that share domains with FN1: view

Function for FN1 Gene

Molecular function for FN1 Gene

GENATLAS Biochemistry: fibronectin 1,plasma,cell adhesion factor,playing a role in the susceptibility to lung fibrosing alveolitis in systemic sclerosis,overexpressed in prostate cancer cells
UniProtKB/Swiss-Prot Function: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts
UniProtKB/Swiss-Prot Function: Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling

LifeMap Function Summary for FN1 Gene

FN1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for FN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 22952693
GO:0005178 integrin binding IMP 24658351
GO:0005515 protein binding IPI 10627046
GO:0005518 collagen binding NAS 3024962
GO:0008201 heparin binding NAS 10075919
genes like me logo Genes that share ontologies with FN1: view
genes like me logo Genes that share phenotypes with FN1: view

Animal Models for FN1 Gene

MGI Knock Outs for FN1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FN1 Gene

Localization for FN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FN1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FN1 Gene COMPARTMENTS Subcellular localization image for FN1 gene
Compartment Confidence
extracellular 5
cytoskeleton 4
plasma membrane 3
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 2
nucleus 2
cytosol 1
endosome 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005577 fibrinogen complex IDA 3997886
GO:0005604 basement membrane --
GO:0005605 basal lamina IEA --
GO:0005615 extracellular space IDA 20551380
genes like me logo Genes that share ontologies with FN1: view

Pathways for FN1 Gene

genes like me logo Genes that share pathways with FN1: view

Gene Ontology (GO) - Biological Process for FN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0002576 platelet degranulation TAS --
GO:0006953 acute-phase response IEA --
GO:0007044 cell-substrate junction assembly IEA --
GO:0007155 cell adhesion NAS 1423622
genes like me logo Genes that share ontologies with FN1: view

Compounds for FN1 Gene

(2) HMDB Compounds for FN1 Gene

Compound Synonyms Cas Number PubMed IDs
Aldosterone
  • (+)-Aldosterone
52-39-1
Heparin
  • Arteven
9005-49-6

(1) Drugbank Compounds for FN1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Ocriplasmin
1048016-9-6 target cleavage

(119) Novoseek inferred chemical compound relationships for FN1 Gene

Compound -log(P) Hits PubMed IDs
grgdsp 73.7 7
grgds 64.6 11
grgesp 61.2 3
fibronectins 59 3
fibrinogen 56.3 127
genes like me logo Genes that share compounds with FN1: view

Transcripts for FN1 Gene

Unigene Clusters for FN1 Gene

Fibronectin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FN1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

ExUns: 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b ^ 33a · 33b ^ 34a · 34b · 34c ^ 35 ^ 36 ^ 37a · 37b ^ 38 ^ 39 ^ 40 ^ 41a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8:
SP9:
SP10: -
SP11: -
SP12:
SP13:
SP14:
SP15: -
SP16:
SP17:
SP18:
SP19:

ExUns: 41b · 41c ^ 42a · 42b ^ 43a · 43b · 43c · 43d ^ 44a · 44b ^ 45a · 45b · 45c ^ 46a · 46b ^ 47a · 47b ^ 48a · 48b
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - -
SP8:
SP9:
SP10: -
SP11: - -
SP12: - -
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:
SP19:

Relevant External Links for FN1 Gene

GeneLoc Exon Structure for
FN1
ECgene alternative splicing isoforms for
FN1

Expression for FN1 Gene

mRNA expression in normal human tissues for FN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FN1 Gene

This gene is overexpressed in Artery - Coronary (5.5) and Artery - Aorta (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FN1 Gene

SOURCE GeneReport for Unigene cluster for FN1 Gene Hs.203717

mRNA Expression by UniProt/SwissProt for FN1 Gene

P02751-FINC_HUMAN
Tissue specificity: Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.
genes like me logo Genes that share expressions with FN1: view

Orthologs for FN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FN1 36
  • 99.37 (n)
  • 99.68 (a)
FN1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FN1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FN1 36
  • 90.91 (n)
  • 95.07 (a)
FN1 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fn1 36
  • 87.33 (n)
  • 91.84 (a)
Fn1 16
Fn1 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FN1 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FN1 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fn1 36
  • 87.18 (n)
  • 92.16 (a)
chicken
(Gallus gallus)
Aves FN1 36
  • 77.72 (n)
  • 82 (a)
FN1 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FN1 37
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia fibronectin 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fn1 36
  • 69.77 (n)
  • 72.28 (a)
Str.6682 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3745 36
zebrafish
(Danio rerio)
Actinopterygii col12a1b 37
  • 15 (a)
OneToMany
fn1 36
FN1 (4 of 4) 37
  • 20 (a)
OneToMany
fn1a 36
  • 61.76 (n)
  • 59.79 (a)
fn1a 37
  • 58 (a)
OneToMany
fn1b 37
  • 55 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea D1009.3 37
  • 11 (a)
OneToOne
Species with no ortholog for FN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FN1 Gene

ENSEMBL:
Gene Tree for FN1 (if available)
TreeFam:
Gene Tree for FN1 (if available)

Paralogs for FN1 Gene

Paralogs for FN1 Gene

genes like me logo Genes that share paralogs with FN1: view

Variants for FN1 Gene

Sequence variations from dbSNP and Humsavar for FN1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1263 -- 215,360,620(+) TTTTA(A/G)TAAAT utr-variant-3-prime, downstream-variant-500B
rs1264 -- 215,360,629(+) ATATT(G/T)GGGTC utr-variant-3-prime, downstream-variant-500B
rs6782 -- 215,361,003(-) AAAAA(A/G)TTGTA utr-variant-3-prime
rs11651 -- 215,364,969(-) TGTTA(C/T)GATGA synonymous-codon, reference
rs13652 -- 215,384,864(-) GGAGA(A/G)ACAGG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for FN1 Gene

Variant ID Type Subtype PubMed ID
esv33472 CNV Loss 17666407
dgv1288e1 CNV Complex 17122850

Relevant External Links for FN1 Gene

HapMap Linkage Disequilibrium report
FN1
Human Gene Mutation Database (HGMD)
FN1

Disorders for FN1 Gene

(2) OMIM Diseases for FN1 Gene (135600)

UniProtKB/Swiss-Prot

FINC_HUMAN
  • Glomerulopathy with fibronectin deposits 2 (GFND2) [MIM:601894]: Genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. {ECO:0000269 PubMed:18268355}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(95) Novoseek inferred disease relationships for FN1 Gene

Disease -log(P) Hits PubMed IDs
fibrosarcoma 37.8 12
tumors 37.1 130
ehlers-danlos syndrome 34.8 5
myeloma 34.6 15
vitreoretinopathy proliferative 34.5 3

Relevant External Links for FN1

Genetic Association Database (GAD)
FN1
Human Genome Epidemiology (HuGE) Navigator
FN1
genes like me logo Genes that share disorders with FN1: view

Publications for FN1 Gene

  1. Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of fibronectin. (PMID: 1400330) Balbona K. … Argraves W.S. (J. Biol. Chem. 1992) 3 4 23
  2. Crystal structure of a heparin- and integrin-binding segment of human fibronectin. (PMID: 10075919) Sharma A. … Stuart D.I. (EMBO J. 1999) 3 4 23
  3. Phenotypic and genetic alterations in mammary stroma: implications for tumour progression. (PMID: 11737888) Schor S.L. … Schor A.M. (Breast Cancer Res. 2001) 3 4 23
  4. The expression of migration stimulating factor, a potent oncofetal cytokine, is uniquely controlled by 3'-untranslated region-dependent nuclear sequestration of its precursor messenger RNA. (PMID: 16322219) Kay R.A. … Schor S.L. (Cancer Res. 2005) 3 4 23
  5. Mutations in FN1 cause glomerulopathy with fibronectin deposits. (PMID: 18268355) Castelletti F. … Noris M. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 23

Products for FN1 Gene

Sources for FN1 Gene

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