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Aliases for FMOD Gene

Aliases for FMOD Gene

  • Fibromodulin 2 3
  • Keratan Sulfate Proteoglycan Fibromodulin 3 4
  • Collagen-Binding 59 KDa Protein 3 4
  • KSPG Fibromodulin 3 4
  • SLRR2E 3 4
  • FM 3 4
  • Fibromodulin Proteoglycan 2

External Ids for FMOD Gene

Previous GeneCards Identifiers for FMOD Gene

  • GC01M200989
  • GC01M198747
  • GC01M199776
  • GC01M200598
  • GC01M200041
  • GC01M201576
  • GC01M203311
  • GC01M174474

Summaries for FMOD Gene

Entrez Gene Summary for FMOD Gene

  • Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

GeneCards Summary for FMOD Gene

FMOD (Fibromodulin) is a Protein Coding gene. Diseases associated with FMOD include myopia and pseudoachondroplasia. Among its related pathways are Disease and Degradation of the extracellular matrix. An important paralog of this gene is ECM2.

UniProtKB/Swiss-Prot for FMOD Gene

  • Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity).

Gene Wiki entry for FMOD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FMOD Gene

Genomics for FMOD Gene

Regulatory Elements for FMOD Gene

Genomic Location for FMOD Gene

Start:
203,340,621 bp from pter
End:
203,351,489 bp from pter
Size:
10,869 bases
Orientation:
Minus strand

Genomic View for FMOD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FMOD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMOD Gene

Proteins for FMOD Gene

  • Protein details for FMOD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06828-FMOD_HUMAN
    Recommended name:
    Fibromodulin
    Protein Accession:
    Q06828
    Secondary Accessions:
    • Q15331
    • Q8IV47

    Protein attributes for FMOD Gene

    Size:
    376 amino acids
    Molecular mass:
    43179 Da
    Quaternary structure:
    • Binds to type I and type II collagen.

neXtProt entry for FMOD Gene

Proteomics data for FMOD Gene at MOPED

Post-translational modifications for FMOD Gene

  • Binds keratan sulfate chains.
  • Glycosylation at Asn127, Asn166, Asn201, Asn291, and Asn341
  • Modification sites at PhosphoSitePlus

Other Protein References for FMOD Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for FMOD (Fibromodulin/FMOD)

No data available for DME Specific Peptides for FMOD Gene

Domains for FMOD Gene

Gene Families for FMOD Gene

HGNC:
  • SLRR :Proteoglycans / Extracellular Matrix : Small leucine-rich repeats

Suggested Antigen Peptide Sequences for FMOD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q06828

UniProtKB/Swiss-Prot:

FMOD_HUMAN :
  • Q06828
Domain:
  • Contains 1 LRRNT domain.
Family:
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
Similarity:
  • Contains 11 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FMOD: view

Function for FMOD Gene

Molecular function for FMOD Gene

GENATLAS Biochemistry:
fibromodulin,small collagen-binding proteoglycan of the extra-cellular matrix,mainly expressed in articular cartilage,tendon,ligament,leucine-rich repeat (LRR) family
UniProtKB/Swiss-Prot Function:
Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for FMOD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FMOD: view
genes like me logo Genes that share phenotypes with FMOD: view

Animal Models for FMOD Gene

MGI Knock Outs for FMOD:

miRNA for FMOD Gene

miRTarBase miRNAs that target FMOD

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FMOD Gene

Localization for FMOD Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMOD Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FMOD Gene COMPARTMENTS Subcellular localization image for FMOD gene
Compartment Confidence
extracellular 5
golgi apparatus 4
lysosome 4
vacuole 4

Gene Ontology (GO) - Cellular Components for FMOD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 20551380
GO:0005796 Golgi lumen TAS --
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
genes like me logo Genes that share ontologies with FMOD: view

Pathways for FMOD Gene

genes like me logo Genes that share pathways with FMOD: view

Pathways by source for FMOD Gene

Gene Ontology (GO) - Biological Process for FMOD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0007181 transforming growth factor beta receptor complex assembly TAS 8093006
GO:0018146 keratan sulfate biosynthetic process TAS --
GO:0030198 extracellular matrix organization TAS --
GO:0030203 glycosaminoglycan metabolic process TAS --
genes like me logo Genes that share ontologies with FMOD: view

Compounds for FMOD Gene

(1) HMDB Compounds for FMOD Gene

Compound Synonyms Cas Number PubMed IDs
Keratan
  • Kerato sulfate
69992-87-6

(12) Novoseek inferred chemical compound relationships for FMOD Gene

Compound -log(P) Hits PubMed IDs
keratan sulfate 85.5 11
chondroitin sulfate 65.1 6
glycosaminoglycan 62.7 2
polylactosamine 53.8 3
chondroitin 53.2 2
genes like me logo Genes that share compounds with FMOD: view

Transcripts for FMOD Gene

mRNA/cDNA for FMOD Gene

Unigene Clusters for FMOD Gene

Fibromodulin:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FMOD

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FMOD Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - -
SP2: - - - - - -
SP3: - -
SP4: -
SP5: - - - - - -
SP6: -
SP7: - - - - -

Relevant External Links for FMOD Gene

GeneLoc Exon Structure for
FMOD
ECgene alternative splicing isoforms for
FMOD

Expression for FMOD Gene

mRNA expression in normal human tissues for FMOD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FMOD Gene

This gene is overexpressed in Artery - Aorta (7.8), Artery - Coronary (7.5), and Artery - Tibial (5.2).

Protein differential expression in normal tissues for FMOD Gene

This gene is overexpressed in Cerebral cortex (12.6), Ovary (7.3), Uterus (7.1), and Spinal cord (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FMOD Gene

SOURCE GeneReport for Unigene cluster for FMOD Gene Hs.519168

genes like me logo Genes that share expressions with FMOD: view

Expression partners for FMOD Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FMOD Gene

Orthologs for FMOD Gene

This gene was present in the common ancestor of chordates.

Orthologs for FMOD Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FMOD 35
  • 90.84 (n)
  • 92 (a)
FMOD 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FMOD 35
  • 91.67 (n)
  • 94.15 (a)
FMOD 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fmod 35
  • 88.74 (n)
  • 92.55 (a)
Fmod 16
Fmod 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FMOD 35
  • 99.73 (n)
  • 100 (a)
FMOD 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fmod 35
  • 88.56 (n)
  • 92.29 (a)
oppossum
(Monodelphis domestica)
Mammalia FMOD 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves FMOD 35
  • 73.24 (n)
  • 70.96 (a)
FMOD 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FMOD 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fmod 35
  • 65.09 (n)
  • 66.57 (a)
zebrafish
(Danio rerio)
Actinopterygii fmodb 35
  • 60.57 (n)
  • 57.19 (a)
fmoda 36
  • 55 (a)
OneToMany
fmodb 36
  • 46 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToMany
Species with no ortholog for FMOD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FMOD Gene

ENSEMBL:
Gene Tree for FMOD (if available)
TreeFam:
Gene Tree for FMOD (if available)

Paralogs for FMOD Gene

Paralogs for FMOD Gene

Selected SIMAP similar genes for FMOD Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FMOD: view

Variants for FMOD Gene

Sequence variations from dbSNP and Humsavar for FMOD Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4605 -- 203,340,838(+) AGAAC(C/G)TAGTC utr-variant-3-prime, nc-transcript-variant
rs7208 -- 203,340,752(-) TGCCC(C/T)CTGCC utr-variant-3-prime, nc-transcript-variant
rs883151 -- 203,346,232(-) AACCG(C/T)ACCAT intron-variant
rs1126423 -- 203,348,259(-) TGGAC(C/G)TCCCT reference, synonymous-codon, intron-variant
rs1891180 -- 203,342,608(+) GGGGA(C/T)GGAGG intron-variant

Relevant External Links for FMOD Gene

HapMap Linkage Disequilibrium report
FMOD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FMOD Gene

Disorders for FMOD Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for FMOD Gene in MalaCards »

(3) Diseases for FMOD Gene including...

(1) University of Copenhagen DISEASES for FMOD Gene

(11) Novoseek inferred disease relationships for FMOD Gene

Disease -log(P) Hits PubMed IDs
collagen fibril 76.1 14
psach 60.5 2
lymphocytic leukemia chronic b-cell 57.5 1
arthritis 36.7 1
refractive errors 27.1 1

Relevant External Links for FMOD

Genetic Association Database (GAD)
FMOD
Human Genome Epidemiology (HuGE) Navigator
FMOD
genes like me logo Genes that share disorders with FMOD: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for FMOD Gene

Publications for FMOD Gene

  1. Localization of the human fibromodulin gene (FMOD) to chromosome 1q32 and completion of the cDNA sequence. (PMID: 7851907) Sztrolovics R. … Korenberg J.R. (Genomics 1994) 2 3 23
  2. Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. (PMID: 8093006) Hildebrand A. … Ruoslahti E. (Biochem. J. 1994) 3 4 23
  3. Structure and deduced amino acid sequence of the human fibromodulin gene. (PMID: 8357838) Antonsson P. … Oldberg A. (Biochim. Biophys. Acta 1993) 3 4 23
  4. Sclera-related gene polymorphisms in high myopia. (PMID: 19710942) Lin H.J. … Tsai F.J. (Mol. Vis. 2009) 3 23 48
  5. Ultraviolet B and A irradiation induces fibromodulin expression in human fibroblasts in vitro. (PMID: 19041686) Iovine B. … Monfrecola G. (Biochimie 2009) 3 23

Products for FMOD Gene

Sources for FMOD Gene

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