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Aliases for FMOD Gene

Aliases for FMOD Gene

  • Fibromodulin 2 3 3 5
  • Keratan Sulfate Proteoglycan Fibromodulin 3 4
  • Collagen-Binding 59 KDa Protein 3 4
  • KSPG Fibromodulin 3 4
  • SLRR2E 3 4
  • FM 3 4
  • Fibromodulin Proteoglycan 2

External Ids for FMOD Gene

Previous GeneCards Identifiers for FMOD Gene

  • GC01M200989
  • GC01M198747
  • GC01M199776
  • GC01M200598
  • GC01M200041
  • GC01M201576
  • GC01M203311
  • GC01M174474

Summaries for FMOD Gene

Entrez Gene Summary for FMOD Gene

  • Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

GeneCards Summary for FMOD Gene

FMOD (Fibromodulin) is a Protein Coding gene. Diseases associated with FMOD include Myopia and Achondrogenesis, Type Ii Or Hypochondrogenesis. Among its related pathways are Keratan sulfate/keratin metabolism and Chondroitin sulfate/dermatan sulfate metabolism. An important paralog of this gene is LUM.

UniProtKB/Swiss-Prot for FMOD Gene

  • Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity).

Gene Wiki entry for FMOD Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FMOD Gene

Genomics for FMOD Gene

Regulatory Elements for FMOD Gene

Enhancers for FMOD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G203319 2.1 FANTOM5 Ensembl ENCODE dbSUPER 17.2 +27.1 27096 9.8 HDGF FOXA2 PKNOX1 CREB3L1 ARNT ZFP64 WRNIP1 SIN3A FEZF1 YBX1 FMOD LOC100131747 BTG2 TMEM183A RABIF KLHL12 LAX1 ZBED6 GC01M203320 RNU6-487P
GH01G203349 1.1 Ensembl ENCODE 20.6 +0.7 708 2.5 HDGF PKNOX1 TCF12 ZNF143 RELB CREM IKZF2 EGR2 USF2 GATAD2B FMOD RNU6-487P GC01M203320
GH01G203284 2.1 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +62.9 62893 8.4 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A YBX1 ZNF766 BTG2 RNU6-487P PRELP FMOD LOC100131747 LINC01353 RABIF ADIPOR1 KLHL12 LINC01136
GH01G203272 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +77.1 77111 3.6 HDGF FOXA2 CREB3L1 ARNT WRNIP1 SIN3A FEZF1 ZNF2 ZBTB7B YY1 BTG2 LINC01136 RNU6-487P FMOD LOC100131747 OPTC PRELP CHIT1 LINC01353
GH01G203276 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +71.1 71102 7.9 HDGF PKNOX1 FOXA2 FEZF1 ZNF48 ZNF121 GLIS2 TSHZ1 ZNF518A ZNF579 BTG2 LINC01136 RNU6-487P FMOD LOC100131747 OPTC PRELP LINC01353 RABIF TMEM183A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FMOD on UCSC Golden Path with GeneCards custom track

Genomic Location for FMOD Gene

Chromosome:
1
Start:
203,340,621 bp from pter
End:
203,351,489 bp from pter
Size:
10,869 bases
Orientation:
Minus strand

Genomic View for FMOD Gene

Genes around FMOD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FMOD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FMOD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMOD Gene

Proteins for FMOD Gene

  • Protein details for FMOD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06828-FMOD_HUMAN
    Recommended name:
    Fibromodulin
    Protein Accession:
    Q06828
    Secondary Accessions:
    • Q15331
    • Q8IV47

    Protein attributes for FMOD Gene

    Size:
    376 amino acids
    Molecular mass:
    43179 Da
    Quaternary structure:
    • Binds to type I and type II collagen.

    Three dimensional structures from OCA and Proteopedia for FMOD Gene

neXtProt entry for FMOD Gene

Post-translational modifications for FMOD Gene

  • Binds keratan sulfate chains.
  • Glycosylation at isoforms=127, Asn166, Asn201, Asn291, and isoforms=341
  • Modification sites at PhosphoSitePlus

Other Protein References for FMOD Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for FMOD (Fibromodulin/FMOD)

No data available for DME Specific Peptides for FMOD Gene

Domains & Families for FMOD Gene

Gene Families for FMOD Gene

Suggested Antigen Peptide Sequences for FMOD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q06828

UniProtKB/Swiss-Prot:

FMOD_HUMAN :
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
Family:
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
genes like me logo Genes that share domains with FMOD: view

Function for FMOD Gene

Molecular function for FMOD Gene

GENATLAS Biochemistry:
fibromodulin,small collagen-binding proteoglycan of the extra-cellular matrix,mainly expressed in articular cartilage,tendon,ligament,leucine-rich repeat (LRR) family
UniProtKB/Swiss-Prot Function:
Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity).
genes like me logo Genes that share phenotypes with FMOD: view

Animal Models for FMOD Gene

MGI Knock Outs for FMOD:

Animal Model Products

CRISPR Products

miRNA for FMOD Gene

miRTarBase miRNAs that target FMOD

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FMOD

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FMOD Gene

Localization for FMOD Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMOD Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FMOD gene
Compartment Confidence
extracellular 5
lysosome 5
golgi apparatus 4
plasma membrane 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FMOD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix TAS,IBA --
GO:0005615 extracellular space IDA 20551380
GO:0005796 Golgi lumen TAS --
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
genes like me logo Genes that share ontologies with FMOD: view

Pathways & Interactions for FMOD Gene

genes like me logo Genes that share pathways with FMOD: view

Gene Ontology (GO) - Biological Process for FMOD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007181 transforming growth factor beta receptor complex assembly TAS 8093006
GO:0007409 NOT axonogenesis IBA --
GO:0018146 keratan sulfate biosynthetic process TAS --
GO:0030199 collagen fibril organization IEA --
GO:0042340 keratan sulfate catabolic process TAS --
genes like me logo Genes that share ontologies with FMOD: view

No data available for SIGNOR curated interactions for FMOD Gene

Drugs & Compounds for FMOD Gene

(7) Drugs for FMOD Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for FMOD Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Keratan
  • Keratan 6'-sulfate
  • Keratan 6'-sulphate
  • Keratan sulfate
  • Keratan sulphate
  • Kerato 6'-sulfate
69992-87-6
genes like me logo Genes that share compounds with FMOD: view

Transcripts for FMOD Gene

mRNA/cDNA for FMOD Gene

Unigene Clusters for FMOD Gene

Fibromodulin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FMOD

Alternative Splicing Database (ASD) splice patterns (SP) for FMOD Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - -
SP2: - - - - - -
SP3: - -
SP4: -
SP5: - - - - - -
SP6: -
SP7: - - - - -

Relevant External Links for FMOD Gene

GeneLoc Exon Structure for
FMOD
ECgene alternative splicing isoforms for
FMOD

Expression for FMOD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FMOD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FMOD Gene

This gene is overexpressed in Artery - Aorta (x7.8), Artery - Coronary (x7.5), and Artery - Tibial (x5.2).

Protein differential expression in normal tissues from HIPED for FMOD Gene

This gene is overexpressed in Cerebral cortex (12.6), Ovary (7.3), Uterus (7.1), and Spinal cord (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FMOD Gene



Protein tissue co-expression partners for FMOD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FMOD Gene:

FMOD

SOURCE GeneReport for Unigene cluster for FMOD Gene:

Hs.519168

Evidence on tissue expression from TISSUES for FMOD Gene

  • Nervous system(4.5)
  • Liver(4.1)
  • Bone(3.3)
  • Intestine(3)
  • Lung(2.7)
  • Eye(2.4)
  • Muscle(2.3)
  • Stomach(2.2)
  • Heart(2.1)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with FMOD: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FMOD Gene

Orthologs for FMOD Gene

This gene was present in the common ancestor of chordates.

Orthologs for FMOD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FMOD 34 35
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia FMOD 34 35
  • 91.67 (n)
oppossum
(Monodelphis domestica)
Mammalia FMOD 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FMOD 34 35
  • 90.84 (n)
mouse
(Mus musculus)
Mammalia Fmod 34 16 35
  • 88.74 (n)
rat
(Rattus norvegicus)
Mammalia Fmod 34
  • 88.56 (n)
chicken
(Gallus gallus)
Aves FMOD 34 35
  • 73.24 (n)
lizard
(Anolis carolinensis)
Reptilia FMOD 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fmod 34
  • 65.09 (n)
zebrafish
(Danio rerio)
Actinopterygii fmodb 34 35
  • 60.57 (n)
fmoda 35
  • 55 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
OneToMany
Species where no ortholog for FMOD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FMOD Gene

ENSEMBL:
Gene Tree for FMOD (if available)
TreeFam:
Gene Tree for FMOD (if available)

Paralogs for FMOD Gene

Paralogs for FMOD Gene

(5) SIMAP similar genes for FMOD Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FMOD: view

Variants for FMOD Gene

Sequence variations from dbSNP and Humsavar for FMOD Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000142454 -- 203,346,234(+) GGTGC(A/G)GTTCT intron-variant
rs1000880403 -- 203,351,974(+) GATTT(A/G)GTTTT upstream-variant-2KB
rs1001082272 -- 203,342,689(+) ACTGT(A/G)CCTGC intron-variant
rs1001150789 -- 203,345,060(+) CAAAG(C/T)ACTTT intron-variant
rs1001163160 -- 203,352,890(+) GTGGG(C/T)CACAC upstream-variant-2KB

Variation tolerance for FMOD Gene

Residual Variation Intolerance Score: 68.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FMOD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FMOD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FMOD Gene

Disorders for FMOD Gene

MalaCards: The human disease database

(9) MalaCards diseases for FMOD Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myopia
  • near vision
achondrogenesis, type ii or hypochondrogenesis
  • achondrogenesis, type ii
corneal dystrophy, congenital stromal
  • congenital stromal corneal dystrophy
pilocytic astrocytoma
  • grade i astrocytic tumor
chronic lymphocytic leukemia
  • cll
- elite association - COSMIC cancer census association via MalaCards
Search FMOD in MalaCards View complete list of genes associated with diseases

Relevant External Links for FMOD

Genetic Association Database (GAD)
FMOD
Human Genome Epidemiology (HuGE) Navigator
FMOD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FMOD
genes like me logo Genes that share disorders with FMOD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FMOD Gene

Publications for FMOD Gene

  1. Sclera-related gene polymorphisms in high myopia. (PMID: 19710942) Lin H.J. … Tsai F.J. (Mol. Vis. 2009) 3 22 46 64
  2. Localization of the human fibromodulin gene (FMOD) to chromosome 1q32 and completion of the cDNA sequence. (PMID: 7851907) Sztrolovics R. … Korenberg J.R. (Genomics 1994) 2 3 22 64
  3. Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. (PMID: 8093006) Hildebrand A. … Ruoslahti E. (Biochem. J. 1994) 3 4 22 64
  4. Structure and deduced amino acid sequence of the human fibromodulin gene. (PMID: 8357838) Antonsson P. … Oldberg A. (Biochim. Biophys. Acta 1993) 3 4 22 64
  5. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 3 46 64

Products for FMOD Gene

Sources for FMOD Gene

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