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Aliases for FMOD Gene

Aliases for FMOD Gene

  • Fibromodulin 2 3 5
  • Keratan Sulfate Proteoglycan Fibromodulin 3 4
  • Collagen-Binding 59 KDa Protein 3 4
  • KSPG Fibromodulin 3 4
  • SLRR2E 3 4
  • FM 3 4
  • Fibromodulin Proteoglycan 2

External Ids for FMOD Gene

Previous GeneCards Identifiers for FMOD Gene

  • GC01M200989
  • GC01M198747
  • GC01M199776
  • GC01M200598
  • GC01M200041
  • GC01M201576
  • GC01M203311
  • GC01M174474

Summaries for FMOD Gene

Entrez Gene Summary for FMOD Gene

  • Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

GeneCards Summary for FMOD Gene

FMOD (Fibromodulin) is a Protein Coding gene. Diseases associated with FMOD include Pseudoachondroplasia and Myopia. Among its related pathways are Glycosaminoglycan metabolism and Defective B3GAT3 causes JDSSDHD. An important paralog of this gene is ECM2.

UniProtKB/Swiss-Prot for FMOD Gene

  • Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity).

Gene Wiki entry for FMOD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FMOD Gene

Genomics for FMOD Gene

Regulatory Elements for FMOD Gene

Enhancers for FMOD Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FMOD on UCSC Golden Path with GeneCards custom track

Promoters for FMOD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FMOD on UCSC Golden Path with GeneCards custom track

Genomic Location for FMOD Gene

203,340,621 bp from pter
203,351,489 bp from pter
10,869 bases
Minus strand

Genomic View for FMOD Gene

Genes around FMOD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FMOD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FMOD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMOD Gene

Proteins for FMOD Gene

  • Protein details for FMOD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q15331
    • Q8IV47

    Protein attributes for FMOD Gene

    376 amino acids
    Molecular mass:
    43179 Da
    Quaternary structure:
    • Binds to type I and type II collagen.

neXtProt entry for FMOD Gene

Proteomics data for FMOD Gene at MOPED

Post-translational modifications for FMOD Gene

  • Binds keratan sulfate chains.
  • Glycosylation at Asn 127, Asn 166, Asn 201, Asn 291, and Asn 341
  • Modification sites at PhosphoSitePlus

Other Protein References for FMOD Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for FMOD (Fibromodulin/FMOD)

No data available for DME Specific Peptides for FMOD Gene

Domains & Families for FMOD Gene

Gene Families for FMOD Gene

Suggested Antigen Peptide Sequences for FMOD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 LRRNT domain.
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
  • Contains 11 LRR (leucine-rich) repeats.
  • Contains 1 LRRNT domain.
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
  • Contains 11 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FMOD: view

Function for FMOD Gene

Molecular function for FMOD Gene

GENATLAS Biochemistry:
fibromodulin,small collagen-binding proteoglycan of the extra-cellular matrix,mainly expressed in articular cartilage,tendon,ligament,leucine-rich repeat (LRR) family
UniProtKB/Swiss-Prot Function:
Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity).
genes like me logo Genes that share phenotypes with FMOD: view

Animal Models for FMOD Gene

MGI Knock Outs for FMOD:

Animal Model Products

miRNA for FMOD Gene

miRTarBase miRNAs that target FMOD

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FMOD Gene

Localization for FMOD Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMOD Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for FMOD Gene COMPARTMENTS Subcellular localization image for FMOD gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
golgi apparatus 4
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FMOD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with FMOD: view

Pathways & Interactions for FMOD Gene

genes like me logo Genes that share pathways with FMOD: view

Gene Ontology (GO) - Biological Process for FMOD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018146 keratan sulfate biosynthetic process TAS --
GO:0030199 collagen fibril organization IEA --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0035385 NOT Roundabout signaling pathway IBA --
GO:0042339 keratan sulfate metabolic process TAS --
genes like me logo Genes that share ontologies with FMOD: view

No data available for SIGNOR curated interactions for FMOD Gene

Drugs & Compounds for FMOD Gene

(5) Drugs for FMOD Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(8) Additional Compounds for FMOD Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Keratan 6'-sulfate
  • Keratan 6'-sulphate
  • Keratan sulfate
  • Keratan sulphate
  • Kerato 6'-sulfate
genes like me logo Genes that share compounds with FMOD: view

Transcripts for FMOD Gene

mRNA/cDNA for FMOD Gene

Unigene Clusters for FMOD Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FMOD Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - -
SP2: - - - - - -
SP3: - -
SP4: -
SP5: - - - - - -
SP6: -
SP7: - - - - -

Relevant External Links for FMOD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FMOD Gene

mRNA expression in normal human tissues for FMOD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FMOD Gene

This gene is overexpressed in Artery - Aorta (x7.8), Artery - Coronary (x7.5), and Artery - Tibial (x5.2).

Protein differential expression in normal tissues from HIPED for FMOD Gene

This gene is overexpressed in Cerebral cortex (12.6), Ovary (7.3), Uterus (7.1), and Spinal cord (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FMOD Gene

SOURCE GeneReport for Unigene cluster for FMOD Gene Hs.519168

genes like me logo Genes that share expression patterns with FMOD: view

Protein tissue co-expression partners for FMOD Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FMOD Gene

Orthologs for FMOD Gene

This gene was present in the common ancestor of chordates.

Orthologs for FMOD Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FMOD 35
  • 90.84 (n)
  • 92 (a)
  • 92 (a)
(Canis familiaris)
Mammalia FMOD 35
  • 91.67 (n)
  • 94.15 (a)
  • 94 (a)
(Mus musculus)
Mammalia Fmod 35
  • 88.74 (n)
  • 92.55 (a)
Fmod 16
Fmod 36
  • 93 (a)
(Pan troglodytes)
Mammalia FMOD 35
  • 99.73 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Fmod 35
  • 88.56 (n)
  • 92.29 (a)
(Monodelphis domestica)
Mammalia FMOD 36
  • 91 (a)
(Gallus gallus)
Aves FMOD 35
  • 73.24 (n)
  • 70.96 (a)
  • 69 (a)
(Anolis carolinensis)
Reptilia FMOD 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fmod 35
  • 65.09 (n)
  • 66.57 (a)
(Danio rerio)
Actinopterygii fmodb 35
  • 60.57 (n)
  • 57.19 (a)
fmoda 36
  • 55 (a)
fmodb 36
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
Species with no ortholog for FMOD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FMOD Gene

Gene Tree for FMOD (if available)
Gene Tree for FMOD (if available)

Paralogs for FMOD Gene

Paralogs for FMOD Gene

(5) SIMAP similar genes for FMOD Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FMOD: view

Variants for FMOD Gene

Sequence variations from dbSNP and Humsavar for FMOD Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4605 -- 203,340,838(+) AGAAC(C/G)TAGTC nc-transcript-variant, utr-variant-3-prime
rs7208 -- 203,340,752(-) TGCCC(C/T)CTGCC nc-transcript-variant, utr-variant-3-prime
rs883151 -- 203,346,232(-) AACCG(C/T)ACCAT intron-variant
rs1126423 -- 203,348,259(-) TGGAC(C/G/T)TCCCT intron-variant, reference, synonymous-codon
rs1891180 -- 203,342,608(+) GGGGA(C/T)GGAGG intron-variant

Variation tolerance for FMOD Gene

Residual Variation Intolerance Score: 68.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for FMOD Gene

Disorders for FMOD Gene

MalaCards: The human disease database

(8) MalaCards diseases for FMOD Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • pseudoachondroplastic dysplasia
  • near vision
chronic lymphocytic leukemia
  • cll
corneal dystrophy, congenital stromal
  • congenital stromal corneal dystrophy
achondrogenesis, type ii or hypochondrogenesis
  • achondrogenesis type ii
- elite association - COSMIC cancer census association via MalaCards
Search FMOD in MalaCards View complete list of genes associated with diseases

Relevant External Links for FMOD

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FMOD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FMOD Gene

Publications for FMOD Gene

  1. Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. (PMID: 8093006) Hildebrand A. … Ruoslahti E. (Biochem. J. 1994) 3 4 23 67
  2. Localization of the human fibromodulin gene (FMOD) to chromosome 1q32 and completion of the cDNA sequence. (PMID: 7851907) Sztrolovics R. … Korenberg J.R. (Genomics 1994) 2 3 23
  3. Ultraviolet B and A irradiation induces fibromodulin expression in human fibroblasts in vitro. (PMID: 19041686) Iovine B. … Monfrecola G. (Biochimie 2009) 3 23
  4. Adenovirus-mediated gene transfer of fibromodulin inhibits neointimal hyperplasia in an organ culture model of human saphenous vein graft disease. (PMID: 19474808) Ranjzad P. … Kingston P.A. (Gene Ther. 2009) 3 23
  5. The tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of heparin-binding proteins, including bioactive factors. (PMID: 19700767) Tillgren V. … HeinegAYrd D. (J. Biol. Chem. 2009) 3 23

Products for FMOD Gene

Sources for FMOD Gene