Aliases for FMOD Gene
External Ids for FMOD Gene
Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
GeneCards Summary for FMOD Gene
FMOD (Fibromodulin) is a Protein Coding gene. Diseases associated with FMOD include myopia and chronic lymphocytic leukemia. Among its related pathways are Disease and Degradation of the extracellular matrix. An important paralog of this gene is ECM2.
UniProtKB/Swiss-Prot for FMOD Gene
Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity).