Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FMOD Gene

protein-coding   GIFtS: 65
GCID: GC01M203311

Fibromodulin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
fibromodulin1 2     SLRR2E2 3
Collagen-Binding 59 KDa Protein2 3     KSPG Fibromodulin2 3
Keratan Sulfate Proteoglycan Fibromodulin2 3     Fibromodulin Proteoglycan1
FM2 3     

External Ids:    HGNC: 37741   Entrez Gene: 23312   Ensembl: ENSG000001221767   OMIM: 6002455   UniProtKB: Q068283   
ORGUL members:         

Export aliases for FMOD gene to outside databases

Previous GC identifers: GC01M200989 GC01M198747 GC01M199776 GC01M200598 GC01M200041 GC01M201576 GC01M174474


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FMOD Gene:
Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central
region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing
disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of
fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also
regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this
gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Jun 2013)

GeneCards Summary for FMOD Gene:
FMOD (fibromodulin) is a protein-coding gene. Diseases associated with FMOD include kniest dysplasia, and hypochondrogenesis. An important paralog of this gene is PODN.

UniProtKB/Swiss-Prot: FMOD_HUMAN, Q06828
Function: Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By
similarity)

Gene Wiki entry for FMOD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the FMOD gene promoter:
         HFH-3   STAT1   STAT1beta   C/EBPalpha   GATA-2   STAT1alpha   FOXI1   c-Rel   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFMOD promoter sequence
   Search Chromatin IP Primers for FMOD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FMOD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

FMOD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FMOD gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M203311:  view genomic region     (about GC identifiers)

Start:
203,309,752 bp from pter      End:
203,320,617 bp from pter
Size:
10,866 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FMOD_HUMAN, Q06828 (See protein sequence)
Recommended Name: Fibromodulin precursor  
Size: 376 amino acids; 43179 Da
Subunit: Binds to type I and type II collagen (By similarity)
Secondary accessions: Q15331 Q8IV47

Explore the universe of human proteins at neXtProt for FMOD: NX_Q06828

Explore proteomics data for FMOD at MOPED

Post-translational modifications: 

  • Binds keratan sulfate chains1
  • Glycosylation2 at Asn127, Asn166, Asn201, Asn291, Asn341

  • See FMOD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002014.2  
    ENSEMBL proteins: 
     ENSP00000347041  
    Reactome Protein details: Q06828

    FMOD Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for FMOD
    OriGene Protein Over-expression Lysate for FMOD
    OriGene MassSpec for FMOD
    OriGene Custom Protein Services for FMOD
    GenScript Custom Purified and Recombinant Proteins Services for FMOD
    Novus Biologicals FMOD Protein
    Novus Biologicals FMOD Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FMOD

    FMOD Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FMOD
    R&D Systems Antibodies for FMOD (Fibromodulin/FMOD)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FMOD
    Novus Biologicals FMOD Antibodies
    Abcam antibodies for FMOD
    Cloud-Clone Corp. Antibodies for FMOD
    ThermoFisher Antibody for FMOD
    LSBio Antibodies in human, mouse, rat for FMOD

    FMOD Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FMOD
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FMOD
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FMOD
    Cloud-Clone Corp. CLIAs for FMOD


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SLRR: Proteoglycans / Extracellular Matrix : Small leucine-rich repeats

    4 InterPro protein domains:
     IPR027215 Fibromodulin
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR000372 LRR-contain_N

    Graphical View of Domain Structure for InterPro Entry Q06828

    ProtoNet protein and cluster: Q06828

    1 Blocks protein domain: IPB000372 Cysteine-rich flanking region

    UniProtKB/Swiss-Prot: FMOD_HUMAN, Q06828
    Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily
    Similarity: Contains 11 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRNT domain


    FMOD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FMOD_HUMAN, Q06828
    Function: Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By
    similarity)

         Genatlas biochemistry entry for FMOD:
    fibromodulin,small collagen-binding proteoglycan of the extra-cellular matrix,mainly expressed in articular
    cartilage,tendon,ligament,leucine-rich repeat (LRR) family

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    FMOD for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fmod):
     behavior/neurological  cardiovascular system  growth/size/body  immune system  integument 
     limbs/digits/tail  muscle  skeleton  vision/eye 

    FMOD for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fmodtm1Aol for FMOD

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FMOD
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FMOD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FMOD
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FMOD

    miRNA
    Products:
        
    miRTarBase miRNAs that target FMOD:
    hsa-mir-21-5p (MIRT001188), hsa-mir-124-3p (MIRT022505)

    Block miRNA regulation of human, mouse, rat FMOD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FMOD (see all 17):
    hsa-miR-202 hsa-miR-29b-1* hsa-miR-105 hsa-miR-558 hsa-miR-3119 hsa-miR-2113 hsa-miR-203 hsa-miR-548p
    SwitchGear 3'UTR luciferase reporter plasmidFMOD 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FMOD
    Predesigned siRNA for gene silencing in human, mouse, rat FMOD

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FMOD

    Clone
    Products:
         
    OriGene clones in human, mouse for FMOD (see all 6)
    OriGene ORF clones in mouse, rat for FMOD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FMOD (NM_002023)
    Sino Biological Human cDNA Clone for FMOD
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FMOD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FMOD

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FMOD
    Browse ESI BIO Cell Lines and PureStem Progenitors for FMOD 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMOD


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FMOD_HUMAN, Q06828: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus4
    lysosome4
    vacuole4

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA--
    GO:0005796Golgi lumen TAS--
    GO:0031012colocalizes with extracellular matrix IDA--

    FMOD for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FMOD About   (see all 8)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    2Keratan sulfate/keratin metabolism
    Keratan sulfate/keratin metabolism0.85
    Keratan sulfate degradation0.00
    Keratan sulfate biosynthesis0.85
    3Metabolism
    Metabolism0.38
    4Degradation of the extracellular matrix
    Extracellular matrix organization0.34
    5Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for FMOD
        Articular Cartilage Extracellular Matrix



    3 Reactome Pathways for FMOD
        ECM proteoglycans
    Keratan sulfate biosynthesis
    Keratan sulfate degradation



    FMOD for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FMOD
    Interactions:

        GeneGlobe Interaction Network for FMOD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for FMOD (Q068282, 3 ENSP000003470414) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TGFB1P011373, ENSP000002219304I2D: score=3 STRING: ENSP00000221930
    TGFB2P618123, ENSP000003558964I2D: score=1 STRING: ENSP00000355896
    TGFB3P106003, ENSP000002386824I2D: score=2 STRING: ENSP00000238682
    KERAENSP000002667194STRING: ENSP00000266719
    LUMENSP000002667184STRING: ENSP00000266718
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0007181transforming growth factor beta receptor complex assembly TAS8093006
    GO:0018146keratan sulfate biosynthetic process TAS--
    GO:0030198extracellular matrix organization TAS--
    GO:0030203glycosaminoglycan metabolic process TAS--

    FMOD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FMOD

    1 HMDB Compound for FMOD    About this table
    CompoundSynonyms CAS #PubMed Ids
    KeratanKerato sulfate (see all 4)69992-87-6--

    Selected Novoseek inferred chemical compound relationships for FMOD gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    keratan sulfate 85.5 12 8895216 (2), 9782536 (1), 16046396 (1), 10488504 (1) (see all 10)
    chondroitin sulfate 65.1 6 10207837 (1), 9688269 (1), 11603505 (1), 15982861 (1) (see all 6)
    glycosaminoglycan 62.7 2 8093006 (1), 17293598 (1)
    polylactosamine 53.8 3 8253794 (2), 8895216 (1)
    chondroitin 53.2 2 8093006 (1), 11012890 (1)
    dermatan sulfate 39.1 3 8093006 (1), 9688269 (1), 2287949 (1)
    hyaluronic acid 36.1 4 11991580 (1), 17071473 (1), 11800374 (1), 18300448 (1)
    procollagen 25.6 2 15613083 (1), 15987500 (1)
    leucine 21.5 4 19358237 (2), 17093390 (1), 12704803 (1)
    proline 19.2 3 19155499 (1), 14551531 (1), 15970583 (1)



    FMOD for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FMOD gene: 
    NM_002023.4  

    Unigene Cluster for FMOD:

    Fibromodulin
    Hs.519168  [show with all ESTs]
    Unigene Representative Sequence: NM_002023
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354955(uc001gzr.3) ENST00000493296 ENST00000461936
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FMOD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FMOD (see all 17):
    hsa-miR-202 hsa-miR-29b-1* hsa-miR-105 hsa-miR-558 hsa-miR-3119 hsa-miR-2113 hsa-miR-203 hsa-miR-548p
    SwitchGear 3'UTR luciferase reporter plasmidFMOD 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FMOD
    Predesigned siRNA for gene silencing in human, mouse, rat FMOD
    Clone
    Products:
         
    OriGene clones in human, mouse for FMOD (see all 6)
    OriGene ORF clones in mouse, rat for FMOD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FMOD (NM_002023)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FMOD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FMOD
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FMOD
    OriGene qSTAR qPCR primer pairs in human, mouse for FMOD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FMOD
      QuantiTect SYBR Green Assays in human, mouse, rat FMOD
      QuantiFast Probe-based Assays in human, mouse, rat FMOD

    Additional mRNA sequence: 

    AK092899.1 AK098322.1 AK172740.1 AK291632.1 AK303866.1 BC035281.1 U05291.1 X75546.1 

    23 DOTS entries:

    DT.97798133  DT.100043388  DT.92439944  DT.318027  DT.95166122  DT.121379318  DT.99951357  DT.100039707 
    DT.100039711  DT.92439942  DT.95107399  DT.97860146  DT.99945028  DT.100030965  DT.121379317  DT.121379330 
    DT.121379334  DT.121379342  DT.40105845  DT.100795190  DT.121379320  DT.121379341  DT.95284231 

    Selected AceView cDNA sequences (see all 434):

    BQ181214 BF589721 BM694863 BQ180872 CN479937 AA336865 BQ183871 BM679462 
    BQ181256 BQ183079 BQ181192 BQ181001 BQ183756 BI836713 AI346002 BQ182821 
    CR599949 U05291 AA501983 AI304378 BP345374 AI520874 AI061052 AA336463 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FMOD (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
    SP1:              -     -           -                                       
    SP2:              -     -                 -     -     -     -               
    SP3:              -     -                                                   
    SP4:                    -                                                   
    SP5:              -     -     -     -     -           -                     


    ECgene alternative splicing isoforms for FMOD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FMOD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTGGTGGCT
    FMOD Expression
    About this image


    FMOD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 10 entries
             Intervertebral Disc Annulus Fibrosus Cells Annulus Fibrosus
             Intervertebral disc (IVD) annulus fibrosus (AF) cells
     
     Tendon & Ligament (Muscoskeletal System)    fully expand to see all 4 entries
             Early Tenocyte Cells Limb Tendon Primordia
     
     Bone (Muscoskeletal System)    fully expand to see all 14 entries
             Endochondral Facial Bones
             HyStem+BMP4-induced 4D20.8 cells
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Interzone Cells Stylopod Synovial Joint
             Autopod
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Endoderm progenitor-like cells
    FMOD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FMOD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.519168
        Custom PCR Arrays for FMOD
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FMOD
    OriGene qSTAR qPCR primer pairs in human, mouse for FMOD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FMOD
    QuantiTect SYBR Green Assays in human, mouse, rat FMOD
    QuantiFast Probe-based Assays in human, mouse, rat FMOD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMOD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for FMOD gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fmod1 , 5 fibromodulin1, 5 88.74(n)1
    92.55(a)1
      1 (58.09 cM)5
    142641  NM_021355.31  NP_067330.11 
     1340372545 
    chicken
    (Gallus gallus)
    Aves FMOD1 fibromodulin 73.24(n)
    70.96(a)
      395814  NM_204967.1  NP_990298.1 
    lizard
    (Anolis carolinensis)
    Reptilia FMOD6
    fibromodulin
    69(a)
    1 ↔ 1
    4(118742803-118768180)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fmod1 fibromodulin 65.09(n)
    66.57(a)
      100491938  XM_002932992.2  XP_002933038.2 
    zebrafish
    (Danio rerio)
    Actinopterygii fmodb1 fibromodulin b 60.57(n)
    57.19(a)
      797559  XM_001337991.2  XP_001338027.1 


    ENSEMBL Gene Tree for FMOD (if available)
    TreeFam Gene Tree for FMOD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FMOD gene
    PODN2  FLRT12  PODNL12  KERA2  PRELP2  FLRT32  OMD2  ASPN2  
    BGN2  DCN2  FLRT22  ECM22  LOC1005090912  LUM2  
    5 SIMAP similar genes for FMOD using alignment to 1 protein entry:     FMOD_HUMAN:
    LUM    MST161    KERA    PRELP    OMD

    FMOD for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FMOD (see all 394)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1479322901,2
    --174487242(+) ATGAAA/GCCTAA 1 -- us2k10--------
    rs66829961,2
    C,A--174487305(+) ATCAAT/AGATAA 1 -- us2k1 tfbs312Minor allele frequency- A:0.24NA WA CSA EA 374
    rs66587261,2
    C,A--174487377(+) GTGAGA/CCCCAC 1 -- us2k111Minor allele frequency- C:0.24NA WA CSA EA 372
    rs66716501,2
    C,F,A--174487415(+) TAACCC/TCCCAC 1 -- us2k111Minor allele frequency- T:0.24NA WA CSA EA 373
    rs1466517491,2
    --203309262(+) TCACGA/GTATGA 1 -- int10--------
    rs1484158371,2
    --203309287(+) AGAAAA/GCAAAT 1 -- int10--------
    rs1928789251,2
    --203309308(+) GGTTTA/GTTTTC 1 -- int10--------
    rs1426831291,2
    --203309318(+) CCTCTA/TCCAGG 1 -- int10--------
    rs1510195211,2
    --203309319(+) CTCTTA/CCAGGG 1 -- int10--------
    rs1408177941,2
    --203309407(+) ATACCC/TAGGAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for FMOD (203309752 - 203320617 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FMOD: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FMOD
    DNA2.0 Custom Variant and Variant Library Synthesis for FMOD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600245    OMIM disorders: --

    Selected diseases for FMOD (see all 34):    
    About MalaCards
    kniest dysplasia    hypochondrogenesis    myopia    refractive error
    pseudoachondroplasia    tendinopathy    b-cell chronic lymphocytic leukemia    chronic lymphocytic leukemia
    morquio syndrome b    sly syndrome    chondrodysplasia    mucopolysaccharidoses
    macroglobulinemia    mantle cell lymphoma    vaginitis    age related macular degeneration
    cleft lip    leiomyoma    gingivitis    diabetic nephropathy

    1 disease from the University of Copenhagen DISEASES database for FMOD:
    Osteoarthritis

    FMOD for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for FMOD gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    collagen fibril 76.1 17 15966909 (2), 15592176 (1), 16979885 (1), 10488504 (1) (see all 13)
    psach 60.5 2 8030664 (1), 11691584 (1)
    lymphocytic leukemia chronic b-cell 57.5 1 15741214 (1)
    arthritis 36.7 1 19765101 (1)
    refractive errors 27.1 1 17117407 (1)
    myopia 26.7 7 15592176 (3), 19710942 (2), 17117407 (1)
    scar 0 4 17219096 (2), 11800374 (1)
    renal disease 0 1 11012890 (1)
    inflammation 0 2 16046396 (2)
    tumors 0 1 17071473 (1)

    Genetic Association Database (GAD): FMOD
    Human Genome Epidemiology (HuGE) Navigator: FMOD (2 documents)

    Export disorders for FMOD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FMOD gene, integrated from 10 sources (see all 166):
    (articles sorted by number of sources associating them with FMOD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. (PubMed id 8093006)1, 2, 9 Hildebrand A.... Ruoslahti E. (Biochem. J. 1994)
    2. Sclera-related gene polymorphisms in high myopia. (PubMed id 19710942)1, 4, 9 Lin H.J....Tsai F.J. (Mol. Vis. 2009)
    3. Localization of the human fibromodulin gene (FMOD) to chromosome 1q32 and completion of the cDNA sequence. (PubMed id 7851907)1, 3, 9 Sztrolovics R....Korenberg J.R. (Genomics 1994)
    4. Structure and deduced amino acid sequence of the human fibromodulin gene. (PubMed id 8357838)1, 2, 9 Antonsson P.... Oldberg A. (Biochim. Biophys. Acta 1993)
    5. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Fibromodulin is expressed in leiomyoma and myometrium and regulated by gonadotropin-releasing hormone analogue therapy and TGF-beta through Smad and MAPK-mediated signalling. (PubMed id 16123076)1, 9 Levens E....Chegini N. (Mol. Hum. Reprod. 2005)
    8. The extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q. (PubMed id 16046396)1, 9 SjAPberg A....Blom A.M. (J. Biol. Chem. 2005)
    9. Structural requirements for fibromodulin binding to collagen and the control of type I collagen fibrillogenesis--critical roles for disulphide bonding and the C-terminal region. (PubMed id 9688269)1, 9 Font B....Hulmes D.J. (Eur. J. Biochem. 1998)
    10. Fibromodulin, an extracellular matrix protein: characterization of its unique gene and protein expression in B-cell chronic lymphocytic leukemia and mantle cell lymphoma. (PubMed id 15741214)1, 9 Mikaelsson E....Rabbani H. (Blood 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2331 HGNC: 3774 AceView: FMOD Ensembl:ENSG00000122176 euGenes: HUgn2331
    ECgene: FMOD H-InvDB: FMOD

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FMOD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FMOD Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FMOD gene:
    Search GeneIP for patents involving FMOD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of FMOD
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for FMOD (Fibromodulin/FMOD)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FMOD  
     OriGene qPCR primer pairs and template standards for FMOD   OriGene Protein Over-expression Lysate for FMOD  
     OriGene MassSpec something-or-other for FMOD   OriGene clones in human, mouse for FMOD  
     OriGene qSTAR qPCR primer pairs in human, mouse for FMOD   OriGene Purified Protein for FMOD  
     OriGene ORF clones in mouse, rat for FMOD   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FMOD   OriGene Custom Protein Services for FMOD  

     
     
     Block miRNA regulation of human, mouse, rat FMOD using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FMOD
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FMOD Predesigned siRNA for gene silencing in human, mouse, rat FMOD
     QuantiFast Probe-based Assays in human, mouse, rat FMOD QuantiTect SYBR Green Assays in human, mouse, rat FMOD
     Custom PCR Arrays for FMOD Search Chromatin IP Primers for FMOD
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FMOD  GeneGlobe Interaction Network for FMOD
     Regulatory tfbs in FMOD promoter
     GenScript Custom Purified and Recombinant Proteins Services for FMOD GenScript cDNA clones with any tag delivered in your preferred vector for FMOD
     GenScript Custom Assay Services for FMOD GenScript Custom overexpressing Cell Line Services for FMOD
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FMOD
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for FMOD
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FMOD antibodies
     FMOD proteins
     FMOD lysates
     Antibodies for FMOD
     See all of Abcam's Antibodies, Kits and Proteins for FMOD
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FMOD
     Antibodies for FMOD
     ELISAs for FMOD
     CLIAs for FMOD



     Browse ESI BIO Cell Lines and PureStem Progenitors for FMOD
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMOD
     SwitchGear 3'UTR luciferase reporter plasmids for FMOD
     SwitchGear Promoter luciferase reporter plasmids for FMOD
     ThermoFisher Antibody for FMOD
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FMOD
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FMOD
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FMOD
     LSBio Antibodies in human, mouse, rat for FMOD
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FMOD gene at Home site.
    Version: 3.12.164 25 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4