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FMO9P Gene

pseudogene GIFtS: 25
GCID: GC01P166572

Flavin Containing Monooxygenase 9 Pseudogene

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Flavin Containing Monooxygenase 9 Pseudogene¹ ²

External Ids:	HGNC: 32210¹	Entrez Gene: 116123²	Ensembl: ENSG00000215834⁷

Export aliases for FMO9P gene to outside databases

Previous GC identifers: GC00U921653 GC01P164840 GC01P137820

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FMO9P Gene:

FMO9P (flavin containing monooxygenase 9 pseudogene) is a pseudogene.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000001.10 NC_018912.2 NT_004487.20

Regulatory elements:

Regulatory transcription factor binding sites in the FMO9P gene promoter:
TBP LHX3b/Lhx3b E47 Arnt PPAR-gamma1 S8 FAC1 LHX3a/Lhx3a Cart-1 PPAR-gamma2
Other transcription factors

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Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FMO9P

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.1 Ensembl cytogenetic band: 1q24.1 HGNC cytogenetic band: 1q24.1

FMO9P Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FMO9P gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P166572: view genomic region (about GC identifiers)

Start:	166,572,912 bp from pter	End:	166,600,637 bp from pter
Size:	27,726 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB: --

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	2
endoplasmic reticulum	1
extracellular	1
mitochondrion	1
nucleus	1
peroxisome	1

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for FMO9P gene:

NM_138784.1

Unigene Cluster for FMO9P:

Flavin containing monooxygenase 9 pseudogene

Hs.348539 [show with all ESTs]

Unigene Representative Sequence: BC014341

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000477875(uc010pld.2) ENST00000488458

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Additional mRNA sequence:

BC014341.1 NR_002925.2

1 DOTS entry:

DT.92042066

5 AceView cDNA sequences:

BC014341 BX283830 BF028231 NM_138784 BE566078

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FMO9P expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCGACCACTG

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FMO9P Protein expression data from MOPED¹, PaxDb² and MaxQB³:

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FMO9P Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.348539

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for FMO9P gene from 1 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Fmo9⁵	flavin containing monooxygenase 9	--		1 (74.03 cM) 166662055

ENSEMBL Gene Tree for FMO9P (if available)
TreeFam Gene Tree for FMO9P (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs137862895^1,2		--	166571162(+)	`TTCTTC/TGAATG`	1	--	us2k¹		0	--	--	--	--
rs190086824^1,2		--	166571180(+)	`TGAGAC/TTAAGT`	1	--	us2k¹		0	--	--	--	--
rs182590228^1,2		--	166571194(+)	`TAATTC/TGTAGT`	1	--	us2k¹		0	--	--	--	--
rs185977254^1,2		--	166571227(+)	`TTAGCC/TCAATT`	1	--	us2k¹		0	--	--	--	--
rs474189^1,2	C,F,O,H	--	166571230(-)	`CAGAAT/CTGGGC`	1	--	us2k¹		30		MN NS EA NA WA	3340
rs114132054^1,2	F	--	166571251(+)	`TCAACC/TGTGAT`	1	--	us2k¹		1		WA	118
rs539246^1,2	C,F,O,H	--	166571256(-)	`GCAGTA/GTCACG`	1	--	us2k¹		21		NA EA NS WA	1600
rs192021532^1,2		--	166571287(+)	`ATGCAA/GATTTC`	1	--	us2k¹		0	--	--	--	--
rs73019630^1,2	C,F	--	166571295(+)	`TTCCAC/TGACTG`	1	--	us2k¹		1		WA	2
rs141685702^1,2	C	--	166571303(+)	`CTGTGA/TCAGAC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FMO9P (166572912 - 166600637 bp)

Structural Variations
Database of Genomic Variants (DGV) 10 variations for FMO9P: About this table

Variant ID	Type	Subtype	PubMed ID
esv2674242	CNV	Deletion	23128226
dgv401n71	CNV	Loss	21882294
dgv403n71	CNV	Loss	21882294
dgv402n71	CNV	Loss	21882294
nsv872511	CNV	Loss	21882294
nsv872520	CNV	Loss	21882294
esv34401	CNV	Loss	17911159
essv5010	CNV	CNV	17122850
essv5848	CNV	CNV	17122850
dgv145e1	CNV	Complex	17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with FMO9P About GenesLikeMe

Genetic Association Database (GAD): FMO9P

Export disorders for FMO9P gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FMO9P gene integrated from 10 sources:
(articles sorted by number of sources associating them with FMO9P)

Utopia: connect your pdf to the dynamic
world of online information

Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters. (PubMed id 15077013)^{1, 3} Hernandez D....Shephard E.A. (Pharmacogenetics 2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 116123	HGNC: 32210	AceView: LOC116123	Ensembl:ENSG00000215834	euGenes: HUgn116123
ECgene: FMO9P	H-InvDB: FMO9P

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for FMO9P	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FMO9P gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FMO9P gene:
Search GeneIP for patents involving FMO9P

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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FMO9P Gene

Flavin Containing Monooxygenase 9 Pseudogene

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FMO9P Gene

Flavin Containing Monooxygenase 9 Pseudogene

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