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Aliases for FMO6P Gene

Aliases for FMO6P Gene

  • Flavin Containing Monooxygenase 6 Pseudogene 2 3 5
  • EC 1.14.13.8 4 58
  • FMO6 3 4
  • Novel Flavin Containing Monooxygenase 3
  • Flavin Containing Monooxygenase 6 2
  • Flavin-Containing Monooxygenase 6 4
  • Dimethylaniline Oxidase 6 4
  • FMO 6 4

External Ids for FMO6P Gene

Previous HGNC Symbols for FMO6P Gene

  • FMO6

Previous GeneCards Identifiers for FMO6P Gene

  • GC01P169375
  • GC01P142330

Summaries for FMO6P Gene

GeneCards Summary for FMO6P Gene

FMO6P (Flavin Containing Monooxygenase 6 Pseudogene) is a Pseudogene. GO annotations related to this gene include oxidoreductase activity and NADP binding.

UniProtKB/Swiss-Prot for FMO6P Gene

  • It is probable that this protein is only produced in very small quantity or not at all as the gene coding for it seems to be unable to produce full length transcripts.

Additional gene information for FMO6P Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FMO6P Gene

Genomics for FMO6P Gene

Regulatory Elements for FMO6P Gene

Enhancers for FMO6P Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H171110 0.5 ENCODE dbSUPER 10.8 -26.6 -26592 1 FMO6P FMO3 MIR1295A
GH01H172117 0.5 ENCODE 4.6 +980.2 980226 0 ZNF687 IKZF1 RUNX3 RELA FMO6P GC01P172124 GC01M171926
GH01H171138 1.7 FANTOM5 Ensembl ENCODE dbSUPER 0.7 +3.6 3585 5 NFIB INSM2 FEZF1 THRB ZSCAN9 RAD21 YY1 ZSCAN5C ZNF362 OVOL3 FMO3 MIR1295A FMO6P FMO2
GH01H171126 0.6 ENCODE dbSUPER 0.4 -10.2 -10191 1 ZFX FMO3 MIR1295A FMO6P
GH01H171157 0.8 ENCODE 0.3 +22.4 22423 4 MAX CEBPG ZNF644 RAD21 RARA YY1 TEAD3 HNF4G CREM MAFK FMO3 MIR1295A FMO2 ENSG00000231424 FMO6P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FMO6P on UCSC Golden Path with GeneCards custom track

Genomic Location for FMO6P Gene

Chromosome:
1
Start:
171,137,740 bp from pter
End:
171,161,568 bp from pter
Size:
23,829 bases
Orientation:
Plus strand

Genomic View for FMO6P Gene

Genes around FMO6P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FMO6P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FMO6P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMO6P Gene

Proteins for FMO6P Gene

  • Protein details for FMO6P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60774-FMO6_HUMAN
    Recommended name:
    Putative dimethylaniline monooxygenase [N-oxide-forming] 6
    Protein Accession:
    O60774

    Protein attributes for FMO6P Gene

    Size:
    539 amino acids
    Molecular mass:
    61291 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

neXtProt entry for FMO6P Gene

Selected DME Specific Peptides for FMO6P Gene

O60774:
  • EEGRASIY
  • IGAKPNIP
  • CFERSDD
  • LRKEPVFND
  • GGLWKFSDH
  • EVYFGPC
  • CLEEGLEPTCFE
  • QSQTLQT
  • GARNAILTQW
  • GRASIYQSV
  • TLFKGIFPP
  • EFTETSA
  • GNSGSDIAVELS
  • FGPCSPYQFRL
  • SKEMMCF
  • NIPWLFLTDP
  • GKWDGAR

Post-translational modifications for FMO6P Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for FMO6P Gene

Suggested Antigen Peptide Sequences for FMO6P Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60774

UniProtKB/Swiss-Prot:

FMO6_HUMAN :
  • Belongs to the FMO family.
Family:
  • Belongs to the FMO family.
genes like me logo Genes that share domains with FMO6P: view

No data available for Gene Families for FMO6P Gene

Function for FMO6P Gene

Molecular function for FMO6P Gene

UniProtKB/Swiss-Prot CatalyticActivity:
N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot Function:
It is probable that this protein is only produced in very small quantity or not at all as the gene coding for it seems to be unable to produce full length transcripts.

Enzyme Numbers (IUBMB) for FMO6P Gene

Phenotypes From GWAS Catalog for FMO6P Gene

genes like me logo Genes that share phenotypes with FMO6P: view

Animal Model Products

CRISPR Products

miRNA for FMO6P Gene

miRTarBase miRNAs that target FMO6P

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FMO6P
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FMO6P Gene

Localization for FMO6P Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMO6P Gene

Microsome membrane. Endoplasmic reticulum membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FMO6P gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 2
peroxisome 2
mitochondrion 1
lysosome 1

No data available for Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FMO6P Gene

Pathways & Interactions for FMO6P Gene

SuperPathways for FMO6P Gene

No Data Available

Interacting Proteins for FMO6P Gene

Gene Ontology (GO) - Biological Process for FMO6P Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FMO6P Gene

Drugs & Compounds for FMO6P Gene

(3) Drugs for FMO6P Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0

(4) Additional Compounds for FMO6P Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dimethylaniline-N-oxide
  • Dimethyl(phenyl)amine oxide
  • Dimethylaniline N-oxide
  • N,N-Dimethylaniline N-oxide
  • Nn-dimethylaniline-N-oxide
874-52-2
N,N-Dimethylaniline
  • Dimethylaminobenzene
  • Dimethylaniline
  • Dimethylphenylamine
  • N,N-(Dimethylamino)benzene
  • N,N-Dimethyl-Benzenamine
121-69-7
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with FMO6P: view

Transcripts for FMO6P Gene

mRNA/cDNA for FMO6P Gene

(2) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FMO6P Gene

Flavin containing monooxygenase 6 pseudogene:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FMO6P
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FMO6P Gene

No ASD Table

Relevant External Links for FMO6P Gene

GeneLoc Exon Structure for
FMO6P
ECgene alternative splicing isoforms for
FMO6P

Expression for FMO6P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FMO6P Gene

mRNA differential expression in normal tissues according to GTEx for FMO6P Gene

This gene is overexpressed in Minor Salivary Gland (x16.7), Stomach (x12.4), and Cervix - Endocervix (x7.4).

NURSA nuclear receptor signaling pathways regulating expression of FMO6P Gene:

FMO6P

SOURCE GeneReport for Unigene cluster for FMO6P Gene:

Hs.448988
genes like me logo Genes that share expression patterns with FMO6P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FMO6P Gene

Orthologs for FMO6P Gene

This gene was present in the common ancestor of chordates.

Orthologs for FMO6P Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FMO6P 34
  • 76 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FMO6P 34
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FMO6P 34
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fmo6 34
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FMO6P 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 58 (a)
OneToMany
chicken
(Gallus gallus)
Aves FMO3 34
  • 50 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 72 (a)
ManyToMany
-- 34
  • 56 (a)
ManyToMany
Species where no ortholog for FMO6P was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FMO6P Gene

ENSEMBL:
Gene Tree for FMO6P (if available)
TreeFam:
Gene Tree for FMO6P (if available)

Paralogs for FMO6P Gene

(6) SIMAP similar genes for FMO6P Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FMO6P: view

No data available for Paralogs for FMO6P Gene

Variants for FMO6P Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FMO6P Gene

FMO6_HUMAN-O60774
There are two alleles; one major, FMO6X105 (truncated form) and one minor, FMO6Q105, (shown here) (full-length form similar to the protein found in other mammals) (PubMed:12527699). A nonsense mutation transforms the Gln-105 into a premature stop codon (PubMed:12527699). The truncated protein is catalytically inactive (PubMed:12527699).

Sequence variations from dbSNP and Humsavar for FMO6P Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000049031 -- 171,136,579(+) AGCCT(C/T)CAGGT intron-variant, upstream-variant-2KB
rs1000160082 -- 171,146,905(+) CACAA(C/T)TTGCA intron-variant
rs1000247885 -- 171,138,649(+) GGTAA(A/G)TGAAA intron-variant
rs1000284805 -- 171,159,704(+) AGGCT(A/G)GATTT intron-variant
rs1000332021 -- 171,161,789(+) TGACA(G/T)TAAAT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FMO6P Gene

Variant ID Type Subtype PubMed ID
esv28731 CNV gain+loss 19812545
nsv1144415 CNV deletion 24896259

Variation tolerance for FMO6P Gene

Gene Damage Index Score: 4.88; 67.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FMO6P Gene

Human Gene Mutation Database (HGMD)
FMO6P
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FMO6P

Disorders for FMO6P Gene

Relevant External Links for FMO6P

Genetic Association Database (GAD)
FMO6P
Human Genome Epidemiology (HuGE) Navigator
FMO6P
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FMO6P

No disorders were found for FMO6P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FMO6P Gene

Publications for FMO6P Gene

  1. Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters. (PMID: 15077013) Hernandez D … Shephard EA (Pharmacogenetics 2004) 2 3 22 60
  2. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PMID: 19898482) Ross CJ … CPNDS Consortium (Nature genetics 2009) 3 45 60
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  4. Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. (PMID: 12527699) Furnes B … Schlenk D (Drug metabolism and disposition: the biological fate of chemicals 2003) 3 4 60
  5. Alternative processing of the human FMO6 gene renders transcripts incapable of encoding a functional flavin-containing monooxygenase. (PMID: 12130684) Hines RN … Begun FP (Molecular pharmacology 2002) 3 4 60

Products for FMO6P Gene

Sources for FMO6P Gene

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