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flavin containing monooxygenase 6 pseudogene(Previous name: flavin containing monooxygenase 6 )
(Previous symbol: FMO6)
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Aliases
for FMO6P gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Flavin Containing Monooxygenase 6 Pseudogene1 2 | | Dimethylaniline Oxidase 63 | | FMO61 2 3 | | Flavin-Containing Monooxygenase 63 | | EC 1.14.13.83 8 | | FMO 63 | | Flavin Containing Monooxygenase 61 | | |
| External Ids: | HGNC: 240241 | Entrez Gene: 3887142 | Ensembl: ENSG000001175077 | UniProtKB: O607743 | | ORGUL members: | |
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| NONCODE:n405552 | |
Export aliases for FMO6P gene to outside databasesPrevious GC identifers: GC01P169375 GC01P142330
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Summaries
for FMO6P gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FMO6_HUMAN, O60774Function: It is probable that this protein is only produced in very small quantity or not at all as the gene coding forit seems to be unable to produce full length transcripts
|
Genomic Views
for FMO6P gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FMO6P gene promoter:
p53 NF-YA CBF-C CBF-A CBF-B HSF2 CP1A CP1C NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for FMO6P
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FMO6P |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q24.3 Ensembl cytogenetic band: 1q24.3 HGNC cytogenetic band: 1q24.3FMO6P Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P171106: view genomic region
(about GC identifiers)
Start:
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171,106,879 bp from pter |
End:
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171,130,707 bp from pter |
Size:
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23,829 bases |
Orientation:
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plus strand |
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Proteins
for FMO6P gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FMO6_HUMAN, O60774 (See
protein sequence)Recommended Name: Putative dimethylaniline monooxygenase [N-oxide-forming] 6 Size: 539 amino acids; 61291 Da
Cofactor: FAD (By similarity)
Subcellular location: Microsome membrane (By similarity). Endoplasmic reticulum membrane (By similarity)
Caution: Could be the product of a pseudogeneExplore the universe of human proteins at neXtProt for FMO6P: NX_O60774
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60774
4/17 DME Specific Peptides for FMO6P (O60774) (see all 17)
FMO6P Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000356728 ENSP00000236166
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005792 | microsome |
-- | -- | | GO:0016021 | integral to membrane |
-- | -- | | GO:0031227 | intrinsic to endoplasmic reticulum membrane |
-- | -- |
FMO6P for ontologies About GeneDecksing
FMO6P Antibody Products:
Assay Products for FMO6P: |
Protein
Domains /
Families
for FMO6P gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FMO6P for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O60774ProtoNet protein and cluster: O60774 4 Blocks protein families: IPB000759 Adrenodoxin reductase family signature IPB000960 Flavin-containing monooxygenase (FMO) signature IPB001327 Pyridine nucleotide-disulphide oxidoreductase IPB002255 Flavin-containing monooxygenase (FMO) 3 signature
UniProtKB/Swiss-Prot: FMO6_HUMAN, O60774Similarity: Belongs to the FMO family |
Function
for FMO6P gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FMO6_HUMAN, O60774Function: It is probable that this protein is only produced in very small quantity or not at all as the gene coding forit seems to be unable to produce full length transcriptsCatalytic activity: N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)OEnzyme Number (IUBMB): EC 1.14.13.81 2
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMO6P |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004499 | N,N-dimethylaniline monooxygenase activity |
-- | -- | | GO:0050660 | flavin adenine dinucleotide binding |
-- | -- | | GO:0050661 | NADP binding |
-- | -- |
FMO6P for ontologies About GeneDecksing
|
Pathways & Interactions
for FMO6P gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FMO6P
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/18 Interacting proteins for FMO6P (O607743 ENSP000002361664) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
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Drugs & Compounds
for FMO6P gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FMO6P
5 HMDB Compounds for FMO6P About this table
Search CenterWatch for drugs/clinical trials and news about FMO6P 
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Transcripts
for FMO6P gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
Unigene Cluster for FMO6P: Flavin containing monooxygenase 6 pseudogene Hs.448988 [show with all ESTs]Unigene Representative Sequence: AK1305113 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367754(uc001ghj.1) ENST00000236166 ENST00000529822
Additional cDNA sequence: AK130511.1 NR_002601.1 2 DOTS entries: DT.75112621 DT.121330956 9 AceView cDNA sequences: CB853631 BX282694 AK130511 AI978664 CA944858 BU684072 AI904082 AI904089 AW369695
GeneLoc Exon Structure
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Expression
for FMO6P gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FMO6P expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FMO6P Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FMO6P
SOURCE GeneReport for Unigene cluster: Hs.448988
SABiosciences Custom PCR Arrays for FMO6P
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FMO6P | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FMO6P | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FMO6P | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMO6P |
Orthologs
for FMO6P gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for FMO6P gene from 7/21 species (see all 21) About this table
ENSEMBL Gene Tree for FMO6P (if available)
TreeFam Gene Tree for FMO6P (if available) |
Paralogs
for FMO6P gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FMO6P gene
- FMO22 FMO42 FMO32 FMO52 FMO12
6 SIMAP similar genes for FMO6P using alignment to 2 protein entries: FMO6_HUMAN (see all proteins):FMO3 FMO5 DKFZp667E137 FMO2 FMO1 FMO4
FMO6P for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for FMO6P
PGOHUM00000245064 PGOHUM00000258103 PGOHUM00000258104
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Genomic Variants
for FMO6P gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: FMO6_HUMAN, O60774Polymorphism: There are two alleles; one major, FMO6X105 (truncated form) and one minor, FMO6Q105, (shown here)(full-length form similar to the protein found in other mammals). A nonsense mutation transforms the Gln-105 into apremature stop codon. The truncated protein is catalytically inactive
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FMO6P (171106879 - 171130707 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FMO6P
2 CNVs: 70415 70417
Human Gene Mutation Database (HGMD): FMO6P
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for FMO6P gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FMO6P for disorders About GeneDecksing
2  diseases for FMO6P: About MalaCardstrimethylaminuria hearing loss
Human Genome Epidemiology (HuGE) Navigator: FMO6P (2 documents)
Export disorders for FMO6P gene to outside databases
|
Publications
for FMO6P gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FMO6P gene integrated from 9 sources:
(articles sorted by number of sources associating them with FMO6P) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters. (PubMed id 15077013)1, 3, 9 Hernandez D....Shephard E.A. (2004)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. (PubMed id 12527699)1, 2 Furnes B.... Schlenk D. (2003)
- Alternative processing of the human FMO6 gene renders transcripts incapable of encoding a functional flavin-containing monooxygenase. (PubMed id 12130684)1, 2 Hines R.N.... Begun F.P. (2002)
- Genome-wide association identifies genetic variants as sociated with lentiform nucleus volume in N = 1345 young and elderly subjects. (PubMed id 22903471)1 Hibar D.P....Thompson P.M. (2012)
- Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1 Ross C.J....Hayden M.R. (2009)
- Osmotic regulation of a novel flavin-containing monoo xygenase in primary cultured cells from rainbow trout (Oncorhynchus mykiss). (PubMed id 18372402)9 RodrA-guez-Fuentes G....Schlenk D. (2008)
- A novel flavin-containing monooxygenase from Methylophaga sp strain SK1 and its indigo synthesis in Escherichia coli. (PubMed id 12821131)9 Choi H.S....Kim S.W. (2003)
|
External Searches for FMO6P gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FMO6P gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FMO6P gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FMO6P gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FMO6P | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FMO6P gene:
Search GeneIP for patents involving FMO6P
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FMO6P gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 |
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FMO6P | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FMO6P | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FMO6P | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FMO6P | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FMO6P | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FMO6P |
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 |  |  |  | |
| | | | Search Tocris compounds for FMO6P |
| |  |  |  |  | | | | |
 |
 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMO6P |
|  |  |  | | | | Search ThermoFisher Antibodies for FMO6P |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FMO6P |
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