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Aliases for FMO6P Gene

Aliases for FMO6P Gene

  • Flavin Containing Monooxygenase 6 Pseudogene 2 3
  • EC 1.14.13.8 4 63
  • FMO6 3 4
  • Novel Flavin Containing Monooxygenase 3
  • Flavin Containing Monooxygenase 6 2
  • Flavin-Containing Monooxygenase 6 4
  • Dimethylaniline Oxidase 6 4
  • FMO 6 4

External Ids for FMO6P Gene

Previous HGNC Symbols for FMO6P Gene

  • FMO6

Previous GeneCards Identifiers for FMO6P Gene

  • GC01P169375
  • GC01P142330

Summaries for FMO6P Gene

GeneCards Summary for FMO6P Gene

FMO6P (Flavin Containing Monooxygenase 6 Pseudogene) is a Pseudogene. An important paralog of this gene is FMO4.

UniProtKB/Swiss-Prot for FMO6P Gene

  • It is probable that this protein is only produced in very small quantity or not at all as the gene coding for it seems to be unable to produce full length transcripts

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FMO6P Gene

Genomics for FMO6P Gene

Regulatory Elements for FMO6P Gene

Genomic Location for FMO6P Gene

Start:
171,137,740 bp from pter
End:
171,161,568 bp from pter
Size:
23,829 bases
Orientation:
Plus strand

Genomic View for FMO6P Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FMO6P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMO6P Gene

Proteins for FMO6P Gene

  • Protein details for FMO6P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60774-FMO6_HUMAN
    Recommended name:
    Putative dimethylaniline monooxygenase [N-oxide-forming] 6
    Protein Accession:
    O60774
    Secondary Accessions:

    Protein attributes for FMO6P Gene

    Size:
    539 amino acids
    Molecular mass:
    61291 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

neXtProt entry for FMO6P Gene

Proteomics data for FMO6P Gene at MOPED

Post-translational modifications for FMO6P Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FMO6P Gene

ENSEMBL proteins:

Domains for FMO6P Gene

Suggested Antigen Peptide Sequences for FMO6P Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60774

UniProtKB/Swiss-Prot:

FMO6_HUMAN :
  • O60774
Family:
  • Belongs to the FMO family.
genes like me logo Genes that share domains with FMO6P: view

No data available for Gene Families for FMO6P Gene

Function for FMO6P Gene

Molecular function for FMO6P Gene

UniProtKB/Swiss-Prot CatalyticActivity: N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O
UniProtKB/Swiss-Prot Function: It is probable that this protein is only produced in very small quantity or not at all as the gene coding for it seems to be unable to produce full length transcripts

Enzyme Numbers (IUBMB) for FMO6P Gene

Gene Ontology (GO) - Molecular Function for FMO6P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004499 N,N-dimethylaniline monooxygenase activity --
GO:0016491 oxidoreductase activity --
GO:0050660 flavin adenine dinucleotide binding --
GO:0050661 NADP binding --
genes like me logo Genes that share ontologies with FMO6P: view

miRNA for FMO6P Gene

miRTarBase miRNAs that target FMO6P

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FMO6P Gene

Localization for FMO6P Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMO6P Gene

Microsome membrane. Endoplasmic reticulum membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FMO6P Gene COMPARTMENTS Subcellular localization image for FMO6P gene
Compartment Confidence
endoplasmic reticulum 2
peroxisome 2
plasma membrane 2
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FMO6P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with FMO6P: view

Pathways for FMO6P Gene

SuperPathways for FMO6P Gene

No Data Available

Gene Ontology (GO) - Biological Process for FMO6P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process --
genes like me logo Genes that share ontologies with FMO6P: view

No data available for Pathways by source for FMO6P Gene

Compounds for FMO6P Gene

(5) HMDB Compounds for FMO6P Gene

Compound Synonyms Cas Number PubMed IDs
Dimethylaniline-N-oxide
  • Dimethylaniline N-oxide
874-52-2
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
N,N-Dimethylaniline
  • Dimethylaminobenzene
121-69-7
NADP
  • Adenine-nicotinamide dinucleotide phosphate
53-59-8
NADPH
  • 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
53-57-6
genes like me logo Genes that share compounds with FMO6P: view

Transcripts for FMO6P Gene

mRNA/cDNA for FMO6P Gene

(2) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FMO6P Gene

Flavin containing monooxygenase 6 pseudogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FMO6P Gene

No ASD Table

Relevant External Links for FMO6P Gene

GeneLoc Exon Structure for
FMO6P
ECgene alternative splicing isoforms for
FMO6P

Expression for FMO6P Gene

mRNA expression in normal human tissues for FMO6P Gene

mRNA differential expression in normal tissues according to GTEx for FMO6P Gene

This gene is overexpressed in Minor Salivary Gland (16.7), Stomach (12.4), and Cervix - Endocervix (7.4).

SOURCE GeneReport for Unigene cluster for FMO6P Gene Hs.448988

genes like me logo Genes that share expressions with FMO6P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for FMO6P Gene

Orthologs for FMO6P Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FMO6P Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FMO6P 36
  • 76 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FMO6P 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FMO6P 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fmo6 16
Fmo6 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FMO6P 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
OneToMany
chicken
(Gallus gallus)
Aves FMO3 36
  • 50 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMO1 38
Species with no ortholog for FMO6P:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FMO6P Gene

ENSEMBL:
Gene Tree for FMO6P (if available)
TreeFam:
Gene Tree for FMO6P (if available)

Paralogs for FMO6P Gene

Paralogs for FMO6P Gene

Selected SIMAP similar genes for FMO6P Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for FMO6P Gene

genes like me logo Genes that share paralogs with FMO6P: view

Variants for FMO6P Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FMO6P Gene

O60774-FMO6_HUMAN
There are two alleles; one major, FMO6X105 (truncated form) and one minor, FMO6Q105, (shown here) (full-length form similar to the protein found in other mammals). A nonsense mutation transforms the Gln-105 into a premature stop codon. The truncated protein is catalytically inactive

Sequence variations from dbSNP and Humsavar for FMO6P Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1736564 -- 171,140,916(+) CAGAT(C/T)ATGCC intron-variant
rs1736565 -- 171,143,351(+) ACATA(C/T)AGTTT intron-variant
rs1736567 -- 171,150,061(+) CTGAA(C/G)AAACT intron-variant
rs1736568 -- 171,157,264(+) gacag(G/T)ttcca intron-variant
rs1795241 -- 171,142,226(+) GGAGA(G/T)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FMO6P Gene

Variant ID Type Subtype PubMed ID
esv28731 CNV Gain+Loss 19812545

Relevant External Links for FMO6P Gene

HapMap Linkage Disequilibrium report
FMO6P
Human Gene Mutation Database (HGMD)
FMO6P

Disorders for FMO6P Gene

Relevant External Links for FMO6P

Genetic Association Database (GAD)
FMO6P
Human Genome Epidemiology (HuGE) Navigator
FMO6P
genes like me logo Genes that share disorders with FMO6P: view

No data available for UniProtKB/Swiss-Prot for FMO6P Gene

Publications for FMO6P Gene

  1. Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters. (PMID: 15077013) Hernandez D. … Shephard E.A. (Pharmacogenetics 2004) 2 3 23
  2. Alternative processing of the human FMO6 gene renders transcripts incapable of encoding a functional flavin-containing monooxygenase. (PMID: 12130684) Hines R.N. … Begun F.P. (Mol. Pharmacol. 2002) 3 4
  3. Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. (PMID: 12527699) Furnes B. … Schlenk D. (Drug Metab. Dispos. 2003) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PMID: 19898482) Ross C.J. … Hayden M.R. (Nat. Genet. 2009) 3 48

Products for FMO6P Gene

Sources for FMO6P Gene

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