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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FMO5 Gene

protein-coding GIFtS: 60
GCID: GC01M146655

flavin containing monooxygenase 5

Explore 4 diseases affiliated with
FMO5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Flavin Containing Monooxygenase 5¹ ²
Dimethylaniline Oxidase 5² ³
Hepatic Flavin-Containing Monooxygenase 5² ³
FMO 5² ³
EC 1.14.13.8³ ⁸
Dimethylaniline Monooxygenase [N-Oxide-Forming] 5²

External Ids:	HGNC: 3773¹	Entrez Gene: 2330²	Ensembl: ENSG00000131781⁷	OMIM: 603957⁵	UniProtKB: P49326³

Export aliases for FMO5 gene to outside databases

Previous GC identifers: GC01M144872 GC01M143383 GC01M144001 GC01M144164 GC01M143882 GC01M145124 GC01M120068

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FMO5:

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and

is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation

capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2

found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases

are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs,

pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jan

2009)

UniProtKB/Swiss-Prot: FMO5_HUMAN, P49326

Function: In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme

Gene Wiki entry for FMO5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_167185.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FMO5 gene promoter:
AML1a MyoD NF-kappaB AREB6 Nkx6-1 POU2F1 POU2F1a NF-kappaB2 Pax-4a NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FMO5 promoter sequence

Search SABiosciences Chromatin IP Primers for FMO5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FMO5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.1 Ensembl cytogenetic band: 1q21.1 HGNC cytogenetic band: 1q21.1

FMO5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FMO5 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M146655: view genomic region (about GC identifiers)

Start:	146,646,930 bp from pter	End:	146,714,700 bp from pter
Size:	67,771 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FMO5_HUMAN, P49326 (See protein sequence)

Recommended Name: Dimethylaniline monooxygenase [N-oxide-forming] 5

Size: 533 amino acids; 60221 Da

Cofactor: FAD

Subcellular location: Microsome membrane. Endoplasmic reticulum membrane

Secondary accessions: B2RBG1 C9JJD1 Q8IV22

Alternative splicing: 3 isoforms: P49326-1 P49326-2 P49326-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FMO5: NX_P49326

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P49326

4/13 DME Specific Peptides for FMO5 (P49326) (see all 13)

GKWDGAR

FDLLKYI

GLIQPLG

FATGYSF

FMO5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001138301.1 NP_001138302.1 NP_001452.2

ENSEMBL proteins:

ENSP00000433742 ENSP00000416011 ENSP00000254090 ENSP00000358277 ENSP00000436429

ENSP00000432569

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	Uscn Proteins for FMO5

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005792	microsome	--	--
GO:0016021	integral to membrane	IEA	--
GO:0031227	intrinsic to endoplasmic reticulum membrane	IEA	--
GO:0043231	intracellular membrane-bounded organelle	NAS	--

FMO5 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FMO5 for domains About GeneDecksing

5 InterPro domains/families:

IPR020946 Flavin_mOase-like

IPR012143 DiMe-aniline_mOase

IPR000960 Flavin_mOase

IPR002257 Flavin_mOase_5

IPR016040 NAD(P)-bd_dom

Graphical View of Domain Structure for InterPro Entry P49326

ProtoNet protein and cluster: P49326

3 Blocks protein families:

IPB000960 Flavin-containing monooxygenase (FMO) signature

IPB001327 Pyridine nucleotide-disulphide oxidoreductase

IPB002257 Flavin-containing monooxygenase (FMO) 5 signature

UniProtKB/Swiss-Prot: FMO5_HUMAN, P49326

Similarity: Belongs to the FMO family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FMO5_HUMAN, P49326

Function: In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme

Catalytic activity: N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O

Genatlas biochemistry entry for FMO5:

flavin containing monooxygenase 5,microsomal

Enzyme Number (IUBMB): EC 1.14.13.8¹ ²

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMO5

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004499	N,N-dimethylaniline monooxygenase activity	NAS	--
GO:0050660	flavin adenine dinucleotide binding	IEA	--
GO:0050661	NADP binding	IEA	--

FMO5 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Busulfan Pathway, Pharmacodynamics

Busulfan Pathway, Pharmacodynamics

1.00

Drug metabolism - cytochrome P450

Drug metabolism - cytochrome P450

1.00

Catalytic cycle of mammalian FMOs

Catalytic cycle of mammalian FMOs

1.00

nicotine degradation III

nicotine degradation IV

0.62

Biological oxidations

metapathway biotransformation

0.41

Pathway sources
See GeneCards unified pathways
Show all pathways

3 BioSystems Pathways for FMO5

	Catalytic cycle of mammalian FMOs
	nicotine degradation IV
	metapathway biotransformation

1 PharmGKB Pathway for FMO5

Busulfan Pathway, Pharmacodynamics

1 Kegg Pathway (Kegg details for FMO5):

Drug metabolism - cytochrome P450

FMO5 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FMO5

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for FMO5 (ENSP00000254090⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CYP2D6	ENSP00000353820⁴	STRING: ENSP00000353820
CYP3A4	ENSP00000337915⁴	STRING: ENSP00000337915
CYP3A43	ENSP00000222382⁴	STRING: ENSP00000222382
CYP3A5	ENSP00000222982⁴	STRING: ENSP00000222982
CYP3A7	ENSP00000337450⁴	STRING: ENSP00000337450

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

FMO5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FMO5 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FMO5

7 HMDB Compounds for FMO5 About this table

Compound	Synonyms	CAS #	PubMed Ids
Dimethylaniline-N-oxide	Dimethylaniline N-oxide (see all 4)	874-52-2	--
FAD	1H-Purin-6-amine flavin dinucleotide (see all 21)	146-14-5	--
N,N-Dimethylaniline	Dimethylaminobenzene (see all 9)	121-69-7	--
NADP	Adenine-nicotinamide dinucleotide phosphate (see all 18)	53-59-8	--
NADPH	2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)	53-57-6	--
Oxygen	Oxygen (see all 5)	7782-44-7	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

4 Novoseek chemical compound relationships for FMO5 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
n-octylamine	82.2	1	9580872 (1)
benzydamine	80	3	11012553 (2), 11136294 (1)
methimazole	77	1	9580872 (1)
pyrophosphate	60	3	9580872 (1), 10950853 (1)

Search CenterWatch for drugs/clinical trials and news about FMO5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FMO5 gene (3 alternative transcripts):

NM_001144829.1 NM_001144830.1 NM_001461.2

Unigene Cluster for FMO5:

Flavin containing monooxygenase 5

Hs.642706 [show with all ESTs]

Unigene Representative Sequence: NM_001461

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000527849 ENST00000441068(uc001eph.4) ENST00000254090(uc001epi.2 uc001epj.2)

ENST00000369272 ENST00000465173(uc001epk.4) ENST00000533174 ENST00000533848

ENST00000478432

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Additional cDNA sequence:

AK022172.1 AK222728.1 AK225739.1 AK314647.1 BC020872.1 BC035687.1 L37080.1 Z47553.1

12 DOTS entries:

DT.313560 DT.121342571 DT.40286524 DT.86859079 DT.40111755 DT.121342703 DT.121639372 DT.121342691

DT.121342611 DT.40227180 DT.91757753 DT.91703881

24/93 AceView cDNA sequences (see all 93):

BX090104 CK904173 AI651087 R96387 BM979853 AA633639 CD723762 AI659442

BC035687 AA971542 CB269986 AW300981 AI796533 AA628113 CD724005 Z47553

AW269324 BF435833 AI122949 AA343168 AI081541 AV655236 L37080 BX496153

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for FMO5 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b
SP1:																	-
SP2:																	-		-
SP3:

ECgene alternative splicing isoforms for FMO5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FMO5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

FMO5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Definitive endoderm-like cells (Generation and expan...)

Endoderm progenitor-like cells (Generation and expan...)

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FMO5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FMO5

SOURCE GeneReport for Unigene cluster: Hs.642706

UniProtKB/Swiss-Prot: FMO5_HUMAN, P49326

Tissue specificity: Expressed in fetal and adult liver

SABiosciences Expression via Pathway-Focused PCR Arrays including FMO5:

Drug Metabolism: Phase I Enzymes in human mouse rat

Cellular Stress Responses in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMO5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for FMO5 gene from 8/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC100857724¹	dimethylaniline monooxygenase [N-oxide-forming] 5-like	65.97(n) 67.81(a)		100857724 XM_003641673.1 XP_003641721.1
lizard (Anolis carolinensis)	Reptilia	-- --	--	69(a) 64(a)	1 ↔ many 1 ↔ many	4(73767385-73779701) 4(73758517-73764472)
African clawed frog (Xenopus laevis)	Amphibia	BC059977.1²	--	77.91(n)		BC059977.1
zebrafish (Danio rerio)	Actinopterygii	fmo5²	flavin containing monooxygenase 5	74.18(n)		334666 NM_198910.1
fruit fly (Drosophila melanogaster)	Insecta	Fmo-2³	dimethylaniline monooxygenase (N-oxide forming)	36(a)		42C2 --
worm (Caenorhabditis elegans)	Secernentea	fmo-13³ fmo-3¹	DIMETHYLANILINE MONOOXYGENASE (N-OXIDE FORMING) more³ Protein FMO-3¹	44(a) (best of 6)³ 51.6(n)¹ 45.62(a)¹		III(10766342-10770439)³ 176491¹ NM_066955.4¹ NP_499356.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G62600⁶ AT1G12200⁶ (see all 18)	dimethylaniline monooxygenase (N-oxide forming) (see all 18)	26(a) 26(a) (see all 18)	possible ortholog possible ortholog (see all 18)	1(23179477-23181519) 1(4137533-4140028)
rice (Oryza sativa)	Liliopsida	-- -- (see all 19)	flavin-containing monooxygenase family protein, pu... flavin-containing monooxygenase family protein, pu... (see all 19)	25(a) 25(a) (see all 19)	possible ortholog possible ortholog (see all 19)	10(21652892-21655657) 10(21702686-21705008)

ENSEMBL Gene Tree for FMO5 (if available)
TreeFam Gene Tree for FMO5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FMO5 gene

FMO2² FMO4² FMO3² FMO6P² FMO1²

6 SIMAP similar genes for FMO5 using alignment to 5 protein entries: FMO5_HUMAN (see all proteins):

FMO2 DKFZp667E137 FMO6P FMO4 FMO1 FMO3

FMO5 for paralogs About GeneDecksing

4 Pseudogenes.org Pseudogenes for FMO5
PGOHUM00000245063 PGOHUM00000251139 PGOHUM00000245065 PGOHUM00000251140

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs148651759^1,2		--	146655414(+)	`TAACAA/GAAGTA`	1	--	ds500¹		0	--	--	--	--
rs17355740^1,2	C,F,	--	146655525(+)	`TTCAAT/GAAAGA`	1	--	ds500¹		5		NA CSA WA	258
rs115516920^1,2	F,	--	146655720(+)	`CTTGTA/GCTAGC`	1	--	ds500¹		1		NA	120
rs17359865^1,2	C,F,	--	146655754(+)	`TCTGCC/TAGACC`	1	--	ds500¹		6		NA CSA WA	380
rs189484425^1,2		--	146655836(+)	`TATAAA/GAGTTT`	1	--	ds500¹		0	--	--	--	--
rs72708553^1,2	C,	--	146656040(+)	`AGGAGT/CCCATC`	1	--	ut3¹		3		CSA WA NA	240
rs72708554^1,2	C,	--	146656097(+)	`TATTCC/TGGGAC`	2	R G	mis¹		3		CSA WA NA	240
rs180716493^1,2		--	146656164(+)	`TGTAGA/GATATT`	2	I	syn¹		0	--	--	--	--
rs142231929^1,2		--	146656179(+)	`AACTTA/GGGTTT`	2	P	syn¹		0	--	--	--	--
rs4950385^1,2	C,F,A,H,	--	146656292(+)	`TATCAG/ATGTGA`	1	--	int¹		21		NS EA NA WA CSA	1705

HapMap Linkage Disequilibrium report for FMO5 (146646930 - 146714700 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for FMO5
3 CNVs: 48116 1326 3312
1 Inversion: 29494
Human Gene Mutation Database (HGMD): FMO5

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FMO5 for disorders           About GeneDecksing

OMIM gene information: 603957    OMIM disorders: --

4 diseases for FMO5:    About MalaCards

trimethylaminuria atrioventricular septal defect hearing loss hepatitis

1 disease from the University of Copenhagen DISEASES database for FMO5:

Atrioventricular septal defect

Human Genome Epidemiology (HuGE) Navigator: FMO5 (4 documents)

Export disorders for FMO5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FMO5 gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with FMO5)

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Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog. (PubMed id 7872795)^{1, 2, 9} Overby L.H.... Philpot R.M. (1995)
Localization of human flavin-containing monooxygenase genes FMO2 and FMO5 to chromosome 1q. (PubMed id 8786146)^{1, 3, 9} McCombie R.R....Shephard E.A. (1996)
Physical mapping of the human connexin 40 (GJA5), flavin-containing monooxygenase 5, and natriuretic peptide receptor a genes on 1q21. (PubMed id 9119381)^{1, 3, 9} Gelb B.D....Desnick R.J. (1997)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. (PubMed id 12527699)^{1, 2} Furnes B.... Schlenk D. (2003)
Quantitative analysis of FMO gene mRNA levels in human tissues. (PubMed id 16183778)^{1, 9} Zhang J. and Cashman J.R. (2006)
Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450. (PubMed id 11551524)^{1, 9} Janmohamed A....Shephard E.A. (2001)
Oxidation of ranitidine by isozymes of flavin-containing monooxygenase and cytochrome P450. (PubMed id 11128045)^{1, 9} Chung W.G....Cha Y.N. (2000)
A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities. (PubMed id 8311461)^{1, 9} Lawton M.P....Phillips I.R. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2330	HGNC: 3773	AceView: FMO5	Ensembl:ENSG00000131781	euGenes: HUgn2330
ECgene: FMO5	Kegg: 2330	H-InvDB: FMO5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FMO5	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FMO5	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/fmo5/

Intellectual Property for FMO5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FMO5 gene:
Search GeneIP for patents involving FMO5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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flavin containing monooxygenase 5

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flavin containing monooxygenase 5

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