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FMO5 Gene

protein-coding   GIFtS: 61
GCID: GC01M146655

Flavin Containing Monooxygenase 5

  See FMO5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Flavin Containing Monooxygenase 51 2
Dimethylaniline Oxidase 52 3
Hepatic Flavin-Containing Monooxygenase 52 3
FMO 52 3
EC 1.14.13.83 8
Dimethylaniline Monooxygenase [N-Oxide-Forming] 52

External Ids:    HGNC: 37731   Entrez Gene: 23302   Ensembl: ENSG000001317817   OMIM: 6039575   UniProtKB: P493263   

Export aliases for FMO5 gene to outside databases

Previous GC identifers: GC01M144872 GC01M143383 GC01M144001 GC01M144164 GC01M143882 GC01M145124 GC01M120068


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FMO5 Gene:
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing
monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with
reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme,
FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25
region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft
nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Jan 2009)

GeneCards Summary for FMO5 Gene:
FMO5 (flavin containing monooxygenase 5) is a protein-coding gene. Diseases associated with FMO5 include trimethylaminuria. GO annotations related to this gene include flavin adenine dinucleotide binding and N,N-dimethylaniline monooxygenase activity. An important paralog of this gene is FMO2.

UniProtKB/Swiss-Prot: FMO5_HUMAN, P49326
Function: In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme

Gene Wiki entry for FMO5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FMO5 gene promoter:
         AML1a   MyoD   NF-kappaB   AREB6   Nkx6-1   POU2F1   POU2F1a   NF-kappaB2   Pax-4a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFMO5 promoter sequence
   Search Chromatin IP Primers for FMO5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FMO5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.1   Ensembl cytogenetic band:  1q21.1   HGNC cytogenetic band: 1q21.1

FMO5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FMO5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M146655:  view genomic region     (about GC identifiers)

Start:
146,646,930 bp from pter      End:
146,714,700 bp from pter
Size:
67,771 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FMO5_HUMAN, P49326 (See protein sequence)
Recommended Name: Dimethylaniline monooxygenase [N-oxide-forming] 5  
Size: 533 amino acids; 60221 Da
Cofactor: FAD
Secondary accessions: B2RBG1 C9JJD1 Q8IV22
Alternative splicing: 3 isoforms:  P49326-1   P49326-2   P49326-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FMO5: NX_P49326

Explore proteomics data for FMO5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FMO5 (P49326) (see all 13)
     GKWDGAR  FDLLKYI  GLIQPLG  FATGYSF 


    See FMO5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001138301.1  NP_001138302.1  NP_001452.2  

    ENSEMBL proteins: 
     ENSP00000433742   ENSP00000416011   ENSP00000254090   ENSP00000358277   ENSP00000436429  
     ENSP00000432569  

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    antibodies-online proteins for FMO5 (5 products) 

     
    antibodies-online peptides for FMO5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR020946 Flavin_mOase-like
     IPR012143 DiMe-aniline_mOase
     IPR000960 Flavin_mOase
     IPR002257 Flavin_mOase_5
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry P49326

    ProtoNet protein and cluster: P49326

    3 Blocks protein domains:
    IPB000960 Flavin-containing monooxygenase (FMO) signature
    IPB001327 Pyridine nucleotide-disulphide oxidoreductase
    IPB002257 Flavin-containing monooxygenase (FMO) 5 signature


    UniProtKB/Swiss-Prot: FMO5_HUMAN, P49326
    Similarity: Belongs to the FMO family


    Find genes that share domains with FMO5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FMO5_HUMAN, P49326
    Function: In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme
    Catalytic activity: N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O

         Genatlas biochemistry entry for FMO5:
    flavin containing monooxygenase 5,microsomal

         Enzyme Number (IUBMB): EC 1.14.13.81 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004499N,N-dimethylaniline monooxygenase activity IEA--
    GO:0016491oxidoreductase activity ----
    GO:0050660flavin adenine dinucleotide binding IEA--
    GO:0050661NADP binding IEA--
         
    Find genes that share ontologies with FMO5           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FMO5

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FMO5_HUMAN, P49326: Microsome membrane. Endoplasmic reticulum membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol2
    peroxisome2
    plasma membrane2
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0043231intracellular membrane-bounded organelle ----

    Find genes that share ontologies with FMO5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FMO5 About    
    See pathways by source

    SuperPathContained pathways About
    1Busulfan Pathway, Pharmacodynamics
    Busulfan Pathway, Pharmacodynamics
    Catalytic cycle of mammalian FMOs0.00
    2Chemical carcinogenesis
    Drug metabolism - cytochrome P4500.69
    3Biological oxidations
    metapathway biotransformation0.42
    4acetone degradation I (to methylglyoxal)
    nicotine degradation IV0.33


    Find genes that share SuperPaths with FMO5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for FMO5
        Catalytic cycle of mammalian FMOs
    nicotine degradation IV
    metapathway biotransformation

    1 PharmGKB Pathway for FMO5
        Busulfan Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for FMO5):
        Drug metabolism - cytochrome P450

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FMO5: 
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FMO5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for FMO5 (ENSP000002540904) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYP2D6ENSP000003538204STRING: ENSP00000353820
    CYP3A43ENSP000002223824STRING: ENSP00000222382
    EDEM1ENSP000002564974STRING: ENSP00000256497
    EDEM2ENSP000003636164STRING: ENSP00000363616
    EDEM3ENSP000003181474STRING: ENSP00000318147
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with FMO5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FMO5

    7 HMDB Compounds for FMO5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dimethylaniline-N-oxideDimethylaniline N-oxide (see all 4)874-52-2--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    N,N-DimethylanilineDimethylaminobenzene (see all 9)121-69-7--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    4 Novoseek inferred chemical compound relationships for FMO5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-octylamine 82.2 1 9580872 (1)
    benzydamine 80 3 11012553 (2), 11136294 (1)
    methimazole 77 1 9580872 (1)
    pyrophosphate 60 3 9580872 (1), 10950853 (1)



    Find genes that share compounds with FMO5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FMO5 gene (3 alternative transcripts): 
    NM_001144829.2  NM_001144830.2  NM_001461.3  

    Unigene Cluster for FMO5:

    Flavin containing monooxygenase 5
    Hs.642706  [show with all ESTs]
    Unigene Representative Sequence: NM_001461
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527849 ENST00000441068(uc001eph.4) ENST00000254090(uc001epi.2 uc001epj.2)
    ENST00000369272 ENST00000465173(uc001epk.4) ENST00000533174 ENST00000533848
    ENST00000478432
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    Additional mRNA sequence: 

    AK022172.1 AK222728.1 AK225739.1 AK314647.1 BC020872.1 BC035687.1 L37080.1 Z47553.1 

    12 DOTS entries:

    DT.313560  DT.121342571  DT.40286524  DT.86859079  DT.40111755  DT.121342703  DT.121639372  DT.121342691 
    DT.121342611  DT.40227180  DT.91757753  DT.91703881 

    Selected AceView cDNA sequences (see all 93):

    AA971542 BC035687 AI796533 BX090104 AI659442 AI651087 CD724005 AA633639 
    CB269986 AA628113 CD723762 BM979853 AW300981 R96387 CK904173 BX496153 
    AV655236 AI122949 AW827304 BM021856 AI081541 AI168146 CK904174 CB132895 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FMO5    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                                  -                           
    SP2:                                                  -     -                     
    SP3:                                                                              


    ECgene alternative splicing isoforms for FMO5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FMO5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FMO5 Expression
    About this image


    FMO5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Definitive endoderm-like cells
    FMO5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FMO5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.642706

    UniProtKB/Swiss-Prot: FMO5_HUMAN, P49326
    Tissue specificity: Expressed in fetal and adult liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FMO5: 
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMO5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FMO5 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fmo51 , 5 flavin containing monooxygenase 51, 5 84.24(n)1
    84.05(a)1
      3 (42.23 cM)5
    142631  NM_001161765.11  NP_001155237.11 
     976288045 
    chicken
    (Gallus gallus)
    Aves LOC1008577241 dimethylaniline monooxygenase [N-oxide-forming] 5-like 65.91(n)
    67.68(a)
      100857724  XM_003641673.2  XP_003641721.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    69(a)
    64(a)
    1 ↔ many
    1 ↔ many
    4(73767385-73791723)
    4(73758517-73764472)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC059977.12   -- 77.91(n)    BC059977.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fmo52 flavin containing monooxygenase 5 74.18(n)   334666  NM_198910.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fmo-23 dimethylaniline monooxygenase (N-oxide
    forming)
    36(a)   42C2   --
    worm
    (Caenorhabditis elegans)
    Secernentea fmo-133
    fmo-51
    DIMETHYLANILINE MONOOXYGENASE (N-OXIDE
    FORMING) more3
    fmo-51
    44(a)
    (best of 6)3
    51.68(n)1
    44.75(a)1
      III(10766342-10770439)3
    1785961  NM_070951.41  NP_503352.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FMO16
    Flavin-containing monooxygenase, localized to the ...
    28(a)
    1 → many
    VIII(454229-455527) YHR176W


    ENSEMBL Gene Tree for FMO5 (if available)
    TreeFam Gene Tree for FMO5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FMO5 gene
    FMO22  FMO42  FMO32  FMO6P2  FMO12  
    6 SIMAP similar genes for FMO5 using alignment to 5 protein entries:     FMO5_HUMAN (see all proteins):
    FMO2    DKFZp667E137    FMO6P    FMO4    FMO1    FMO3

    Find genes that share paralogs with FMO5           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for FMO5
    PGOHUM00000245063 PGOHUM00000251139 PGOHUM00000245065 PGOHUM00000251140


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FMO5 (see all 81)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs8944691,2
    C,F,A,H--146672906(-) TTTCCA/GTTTCT 5 P syn1 int1 ese360Minor allele frequency- C:0.00NA EA MN NS WA CSA EU 11949
    rs2000279741,2
    C--146674691(+) AGGTT-/TCCTTCTT 3 -- cds10--------
    rs75433311,2
    C,F,A,H--146674693(+) GGTTTC/TCTTTT 3 -- int1 trp38Minor allele frequency- T:0.12NA WA CSA 16
    rs2007094531,2
    C--146674694(+) GTTTTC/TTTTTT 3 -- int10--------
    rs1423199901,2
    C--146674695(+) TTTTT-/T/TT  
            
    TGACA
    3 -- int10--------
    rs1909583631,2
    C--146674794(+) CATCAC/TGCGAT 3 -- int10--------
    rs1824617291,2
    --146674796(+) TCACGC/GGATTC 3 -- int10--------
    rs564008741,2
    C,F--146674937(+) CCTGAC/TCCACT 3 -- int14Minor allele frequency- T:0.08CSA WA NA 242
    rs560478161,2
    C--146675019(+) ACCAGC/TTTCCA 3 -- int13Minor allele frequency- T:0.07CSA WA NA 240
    rs1879860941,2
    --146675038(+) GTTACA/CGCAGG 3 -- int10--------

    HapMap Linkage Disequilibrium report for FMO5 (146646930 - 146714700 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FMO5 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv67e199CNV Deletion23128226
    esv2717518CNV Deletion23290073
    nsv159869CNV Insertion16902084
    esv273693CNV Insertion20981092
    esv270836CNV Insertion20981092
    nsv437047CNV Loss16327808
    nsv872259CNV Loss21882294
    nsv872258CNV Loss21882294
    nsv872257CNV Gain21882294
    nsv872255CNV Gain21882294

    Human Gene Mutation Database (HGMD): FMO5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FMO5
    DNA2.0 Custom Variant and Variant Library Synthesis for FMO5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603957    OMIM disorders: --

    1 disease for FMO5:    
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    trimethylaminuria


    Find genes that share disorders with FMO5           About GenesLikeMe

    Genetic Association Database (GAD): FMO5
    Human Genome Epidemiology (HuGE) Navigator: FMO5 (4 documents)

    Export disorders for FMO5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FMO5 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with FMO5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog. (PubMed id 7872795)1, 2, 9 Overby L.H.... Philpot R.M. (Arch. Biochem. Biophys. 1995)
    2. Localization of human flavin-containing monooxygenase genes FMO2 and FMO5 to chromosome 1q. (PubMed id 8786146)1, 3, 9 McCombie R.R....Shephard E.A. (Genomics 1996)
    3. Physical mapping of the human connexin 40 (GJA5), flavin-containing monooxygenase 5, and natriuretic peptide receptor a genes on 1q21. (PubMed id 9119381)1, 3, 9 Gelb B.D....Desnick R.J. (Genomics 1997)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    6. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1, 4 Ross C.J....Hayden M.R. (Nat. Genet. 2009)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. (PubMed id 12527699)1, 2 Furnes B.... Schlenk D. (Drug Metab. Dispos. 2003)
    10. Quantitative analysis of FMO gene mRNA levels in human tissues. (PubMed id 16183778)1, 9 Zhang J. and Cashman J.R. (Drug Metab. Dispos. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2330 HGNC: 3773 AceView: FMO5 Ensembl:ENSG00000131781 euGenes: HUgn2330
    ECgene: FMO5 Kegg: 2330 H-InvDB: FMO5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FMO5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FMO5 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fmo5/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FMO5 gene:
    Search GeneIP for patents involving FMO5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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