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Aliases for FMO5 Gene

Aliases for FMO5 Gene

  • Flavin Containing Monooxygenase 5 2 3 5
  • EC 1.14.13.8 4 63
  • Hepatic Flavin-Containing Monooxygenase 5 4
  • Dimethylaniline Oxidase 5 4
  • FMO 5 4

External Ids for FMO5 Gene

Previous GeneCards Identifiers for FMO5 Gene

  • GC01M144872
  • GC01M143383
  • GC01M144001
  • GC01M144164
  • GC01M143882
  • GC01M145124
  • GC01M146655
  • GC01M120068

Summaries for FMO5 Gene

Entrez Gene Summary for FMO5 Gene

  • Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

GeneCards Summary for FMO5 Gene

FMO5 (Flavin Containing Monooxygenase 5) is a Protein Coding gene. Diseases associated with FMO5 include trimethylaminuria and atrioventricular septal defect. Among its related pathways are Metabolism of xenobiotics by cytochrome P450 and Phase II conjugation. GO annotations related to this gene include oxidoreductase activity and NADP binding. An important paralog of this gene is FMO2.

UniProtKB/Swiss-Prot for FMO5 Gene

  • In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.

Gene Wiki entry for FMO5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FMO5 Gene

Genomics for FMO5 Gene

Regulatory Elements for FMO5 Gene

Promoters for FMO5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FMO5 on UCSC Golden Path with GeneCards custom track

Genomic Location for FMO5 Gene

Chromosome:
1
Start:
147,175,351 bp from pter
End:
147,243,050 bp from pter
Size:
67,700 bases
Orientation:
Minus strand

Genomic View for FMO5 Gene

Genes around FMO5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FMO5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FMO5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMO5 Gene

Proteins for FMO5 Gene

  • Protein details for FMO5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49326-FMO5_HUMAN
    Recommended name:
    Dimethylaniline monooxygenase [N-oxide-forming] 5
    Protein Accession:
    P49326
    Secondary Accessions:
    • B2RBG1
    • C9JJD1
    • Q8IV22

    Protein attributes for FMO5 Gene

    Size:
    533 amino acids
    Molecular mass:
    60221 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FMO5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FMO5 Gene

Proteomics data for FMO5 Gene at MOPED

Post-translational modifications for FMO5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for FMO5 Gene

Graphical View of Domain Structure for InterPro Entry

P49326

UniProtKB/Swiss-Prot:

FMO5_HUMAN :
  • Belongs to the FMO family.
Family:
  • Belongs to the FMO family.
genes like me logo Genes that share domains with FMO5: view

No data available for Gene Families for FMO5 Gene

Function for FMO5 Gene

Molecular function for FMO5 Gene

GENATLAS Biochemistry:
flavin containing monooxygenase 5,microsomal
UniProtKB/Swiss-Prot CatalyticActivity:
N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot Function:
In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.

Enzyme Numbers (IUBMB) for FMO5 Gene

Gene Ontology (GO) - Molecular Function for FMO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050661 NADP binding IEA --
genes like me logo Genes that share ontologies with FMO5: view
genes like me logo Genes that share phenotypes with FMO5: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FMO5 Gene

Localization for FMO5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMO5 Gene

Microsome membrane. Endoplasmic reticulum membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FMO5 Gene COMPARTMENTS Subcellular localization image for FMO5 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
peroxisome 2
plasma membrane 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for FMO5 Gene

Pathways & Interactions for FMO5 Gene

genes like me logo Genes that share pathways with FMO5: view

Pathways by source for FMO5 Gene

1 KEGG pathway for FMO5 Gene

Interacting Proteins for FMO5 Gene

Gene Ontology (GO) - Biological Process for FMO5 Gene

None

No data available for SIGNOR curated interactions for FMO5 Gene

Drugs & Compounds for FMO5 Gene

(6) Drugs for FMO5 Gene - From: Novoseek, PharmGKB, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Metformin Approved Pharma AMP-activated protein kinase (AMPK) activator 1645
FAD Approved Pharma 0
Tamoxifen Approved Pharma Antagonist ER antagonist, Anti-Estrogens 350

(11) Additional Compounds for FMO5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dimethylaniline-N-oxide
  • Dimethyl(phenyl)amine oxide
  • Dimethylaniline N-oxide
  • N,N-Dimethylaniline N-oxide
  • Nn-dimethylaniline-N-oxide
874-52-2
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
N,N-Dimethylaniline
  • Dimethylaminobenzene
  • Dimethylaniline
  • Dimethylphenylamine
  • N,N-(Dimethylamino)benzene
  • N,N-Dimethyl-Benzenamine
121-69-7
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with FMO5: view

Transcripts for FMO5 Gene

Unigene Clusters for FMO5 Gene

Flavin containing monooxygenase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FMO5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - -
SP3:

Relevant External Links for FMO5 Gene

GeneLoc Exon Structure for
FMO5
ECgene alternative splicing isoforms for
FMO5

Expression for FMO5 Gene

mRNA expression in normal human tissues for FMO5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FMO5 Gene

This gene is overexpressed in Liver (x12.5) and Stomach (x11.3).

Protein differential expression in normal tissues from HIPED for FMO5 Gene

This gene is overexpressed in Liver (30.9) and Gallbladder (28.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FMO5 Gene



SOURCE GeneReport for Unigene cluster for FMO5 Gene Hs.642706

mRNA Expression by UniProt/SwissProt for FMO5 Gene

P49326-FMO5_HUMAN
Tissue specificity: Expressed in fetal and adult liver.
genes like me logo Genes that share expression patterns with FMO5: view

Protein tissue co-expression partners for FMO5 Gene

Primer Products

In Situ Assay Products

Orthologs for FMO5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FMO5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FMO5 35
  • 87.55 (n)
  • 85.18 (a)
FMO5 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FMO5 35
  • 89.49 (n)
  • 88.74 (a)
FMO5 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fmo5 35
  • 84.24 (n)
  • 84.05 (a)
Fmo5 16
Fmo5 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FMO5 35
  • 99.62 (n)
  • 99.44 (a)
FMO5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fmo5 35
  • 83.99 (n)
  • 84.24 (a)
oppossum
(Monodelphis domestica)
Mammalia FMO5 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FMO5 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857724 35
  • 65.91 (n)
  • 67.68 (a)
-- 36
  • 62 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fmo5 35
fmo5 35
  • 63.65 (n)
  • 63.19 (a)
fmo5 36
  • 58 (a)
ManyToMany
si:dkey-239i20.2 36
  • 56 (a)
ManyToMany
si:dkey-239i20.4 36
  • 50 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Fmo-2 37
  • 36 (a)
Fmo-2 36
  • 31 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C01H6.4 37
  • 32 (a)
fmo-11 37
  • 43 (a)
fmo-12 37
  • 43 (a)
fmo-13 37
  • 44 (a)
fmo-14 37
  • 42 (a)
fmo-15 37
  • 44 (a)
fmo-5 35
  • 51.68 (n)
  • 44.75 (a)
fmo-1 36
  • 41 (a)
ManyToMany
fmo-2 36
  • 42 (a)
ManyToMany
fmo-3 36
  • 44 (a)
ManyToMany
fmo-4 36
  • 37 (a)
ManyToMany
fmo-5 36
  • 43 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMO1 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
Species with no ortholog for FMO5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FMO5 Gene

ENSEMBL:
Gene Tree for FMO5 (if available)
TreeFam:
Gene Tree for FMO5 (if available)

Paralogs for FMO5 Gene

Paralogs for FMO5 Gene

(6) SIMAP similar genes for FMO5 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for FMO5 Gene

genes like me logo Genes that share paralogs with FMO5: view

Variants for FMO5 Gene

Sequence variations from dbSNP and Humsavar for FMO5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_015370 -
rs28381218 - 147,190,235(+) CATTG(C/G)CCTCA reference, missense
rs28381223 - 147,186,984(-) GAAAG(G/T)AGTAG intron-variant, reference, missense, utr-variant-3-prime
rs718369 -- 147,197,315(+) TCTCA(C/T)GGCAG intron-variant
rs894467 -- 147,190,439(+) TCTAC(C/T)TATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FMO5 Gene

Variant ID Type Subtype PubMed ID
nsv7181 OTHER Inversion 18451855
esv529 CNV CNV 17122850
dgv114e1 CNV Complex 17122850
nsv872251 CNV Gain 21882294
nsv872255 CNV Gain 21882294
nsv872257 CNV Gain 21882294
nsv437047 CNV Loss 16327808
esv270836 CNV Insertion 20981092
esv273693 CNV Insertion 20981092
nsv159869 CNV Insertion 16902084
dgv67e199 CNV Deletion 23128226
nsv872258 CNV Loss 21882294
esv2717518 CNV Deletion 23290073
nsv872259 CNV Loss 21882294

Variation tolerance for FMO5 Gene

Residual Variation Intolerance Score: 82.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FMO5 Gene

HapMap Linkage Disequilibrium report
FMO5
Human Gene Mutation Database (HGMD)
FMO5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FMO5 Gene

Disorders for FMO5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FMO5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
trimethylaminuria
  • fish odor syndrome
atrioventricular septal defect
  • atrioventricular canal defect
- elite association - COSMIC cancer census association via MalaCards
Search FMO5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FMO5

Genetic Association Database (GAD)
FMO5
Human Genome Epidemiology (HuGE) Navigator
FMO5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FMO5
genes like me logo Genes that share disorders with FMO5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FMO5 Gene

Publications for FMO5 Gene

  1. Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog. (PMID: 7872795) Overby L.H. … Philpot R.M. (Arch. Biochem. Biophys. 1995) 3 4 23 67
  2. Physical mapping of the human connexin 40 (GJA5), flavin-containing monooxygenase 5, and natriuretic peptide receptor a genes on 1q21. (PMID: 9119381) Gelb B.D. … Desnick R.J. (Genomics 1997) 2 3 23
  3. Localization of human flavin-containing monooxygenase genes FMO2 and FMO5 to chromosome 1q. (PMID: 8786146) McCombie R.R. … Shephard E.A. (Genomics 1996) 2 3 23
  4. Quantitative analysis of FMO gene mRNA levels in human tissues. (PMID: 16183778) Zhang J. … Cashman J.R. (Drug Metab. Dispos. 2006) 3 23
  5. Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450. (PMID: 11551524) Janmohamed A. … Shephard E.A. (Biochem. Pharmacol. 2001) 3 23

Products for FMO5 Gene

Sources for FMO5 Gene

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