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Aliases for FMO5 Gene

Aliases for FMO5 Gene

  • Flavin Containing Monooxygenase 5 2 3 5
  • EC 1.14.13.8 4 61
  • Hepatic Flavin-Containing Monooxygenase 5 4
  • Dimethylaniline Oxidase 5 4
  • FMO 5 4

External Ids for FMO5 Gene

Previous GeneCards Identifiers for FMO5 Gene

  • GC01M144872
  • GC01M143383
  • GC01M144001
  • GC01M144164
  • GC01M143882
  • GC01M145124
  • GC01M146655
  • GC01M120068

Summaries for FMO5 Gene

Entrez Gene Summary for FMO5 Gene

  • Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

GeneCards Summary for FMO5 Gene

FMO5 (Flavin Containing Monooxygenase 5) is a Protein Coding gene. Diseases associated with FMO5 include Trimethylaminuria and Atrioventricular Septal Defect. Among its related pathways are nicotine degradation IV and Drug metabolism - cytochrome P450. GO annotations related to this gene include oxidoreductase activity and NADP binding. An important paralog of this gene is FMO2.

UniProtKB/Swiss-Prot for FMO5 Gene

  • In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.

Gene Wiki entry for FMO5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FMO5 Gene

Genomics for FMO5 Gene

Regulatory Elements for FMO5 Gene

Enhancers for FMO5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G147165 1.7 Ensembl ENCODE dbSUPER 16 +72.9 72943 8.3 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 SSRP1 ZNF610 GLIS1 PRKAB2 CHD1L FMO5 BCL9 ACP6 GC01P147160
GH01G147235 1 ENCODE 12.6 +4.6 4627 5.0 HNRNPUL1 PKNOX1 FOXA2 ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 PRKAB2 CHD1L FMO5 PDIA3P1 ENSG00000237188 GC01P147224
GH01G147272 1 Ensembl ENCODE 12.3 -31.1 -31082 2.7 CTCF NFIB JUN MAX CEBPG RAD21 FOSL1 GATA2 FOXK2 SMC3 ENSG00000237188 CHD1L FMO5 PDIA3P1 PRKAB2 PIR40868 PIR61684
GH01G147224 0.9 ENCODE 12.7 +17.5 17480 1.6 HDAC1 ELF3 ARID4B SIN3A ZBTB40 RAD21 RARA YY1 EGR1 SCRT2 CHD1L FMO5 PDIA3P1 ENSG00000237188 PRKAB2 PDE4DIPP1 GC01P147224
GH01G147161 0.5 dbSUPER 17.4 +80.8 80783 1.9 JUND FOS ZNF7 FMO5 CHD1L PRKAB2 GC01P147160
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FMO5 on UCSC Golden Path with GeneCards custom track

Promoters for FMO5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000013086 -350 2001 HDGF PKNOX1 MLX CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B

Genomic Location for FMO5 Gene

Chromosome:
1
Start:
147,175,351 bp from pter
End:
147,243,050 bp from pter
Size:
67,700 bases
Orientation:
Minus strand

Genomic View for FMO5 Gene

Genes around FMO5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FMO5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FMO5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMO5 Gene

Proteins for FMO5 Gene

  • Protein details for FMO5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49326-FMO5_HUMAN
    Recommended name:
    Dimethylaniline monooxygenase [N-oxide-forming] 5
    Protein Accession:
    P49326
    Secondary Accessions:
    • B2RBG1
    • C9JJD1
    • Q8IV22

    Protein attributes for FMO5 Gene

    Size:
    533 amino acids
    Molecular mass:
    60221 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FMO5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FMO5 Gene

Selected DME Specific Peptides for FMO5 Gene

P49326:
  • EEGRASIY
  • FPFLEDSVKVV
  • SFPGIEKFKG
  • LPLESFPGI
  • EEGLEPVCFER
  • SKEMMCF
  • IGIGNSGGDLAVEIS
  • FDLLKYI
  • FATGYSF
  • SQRHTIQGDYI
  • SLYKKVFPPNLE
  • GKWDGAR
  • GLIQPLG

Post-translational modifications for FMO5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for FMO5 Gene

Graphical View of Domain Structure for InterPro Entry

P49326

UniProtKB/Swiss-Prot:

FMO5_HUMAN :
  • Belongs to the FMO family.
Family:
  • Belongs to the FMO family.
genes like me logo Genes that share domains with FMO5: view

No data available for Gene Families for FMO5 Gene

Function for FMO5 Gene

Molecular function for FMO5 Gene

GENATLAS Biochemistry:
flavin containing monooxygenase 5,microsomal
UniProtKB/Swiss-Prot CatalyticActivity:
N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot Function:
In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.

Enzyme Numbers (IUBMB) for FMO5 Gene

Gene Ontology (GO) - Molecular Function for FMO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004499 N,N-dimethylaniline monooxygenase activity IBA --
GO:0016491 oxidoreductase activity IEA --
GO:0050660 flavin adenine dinucleotide binding IEA --
GO:0050661 NADP binding IEA --
genes like me logo Genes that share ontologies with FMO5: view
genes like me logo Genes that share phenotypes with FMO5: view

Animal Models for FMO5 Gene

MGI Knock Outs for FMO5:

Animal Model Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FMO5 Gene

Localization for FMO5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMO5 Gene

Microsome membrane. Endoplasmic reticulum membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FMO5 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 5
plasma membrane 2
peroxisome 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FMO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FMO5: view

Pathways & Interactions for FMO5 Gene

genes like me logo Genes that share pathways with FMO5: view

Gene Ontology (GO) - Biological Process for FMO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with FMO5: view

No data available for SIGNOR curated interactions for FMO5 Gene

Drugs & Compounds for FMO5 Gene

(7) Drugs for FMO5 Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Metformin Approved Pharma AMP-activated protein kinase (AMPK) activator 1803
FAD Approved Pharma 0
Oxygen Approved, Vet_approved Pharma 0
Tamoxifen Approved Pharma Antagonist TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 390
Water Approved Pharma 0

(10) Additional Compounds for FMO5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dimethylaniline-N-oxide
  • Dimethyl(phenyl)amine oxide
  • Dimethylaniline N-oxide
  • N,N-Dimethylaniline N-oxide
  • Nn-dimethylaniline-N-oxide
874-52-2
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
N,N-Dimethylaniline
  • Dimethylaminobenzene
  • Dimethylaniline
  • Dimethylphenylamine
  • N,N-(Dimethylamino)benzene
  • N,N-Dimethyl-Benzenamine
121-69-7
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with FMO5: view

Transcripts for FMO5 Gene

Unigene Clusters for FMO5 Gene

Flavin containing monooxygenase 5:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FMO5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - -
SP3:

Relevant External Links for FMO5 Gene

GeneLoc Exon Structure for
FMO5
ECgene alternative splicing isoforms for
FMO5

Expression for FMO5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FMO5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FMO5 Gene

This gene is overexpressed in Liver (x12.5) and Stomach (x11.3).

Protein differential expression in normal tissues from HIPED for FMO5 Gene

This gene is overexpressed in Liver (30.9) and Gallbladder (28.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FMO5 Gene



Protein tissue co-expression partners for FMO5 Gene

NURSA nuclear receptor signaling pathways regulating expression of FMO5 Gene:

FMO5

SOURCE GeneReport for Unigene cluster for FMO5 Gene:

Hs.642706

mRNA Expression by UniProt/SwissProt for FMO5 Gene:

P49326-FMO5_HUMAN
Tissue specificity: Expressed in fetal and adult liver.

Evidence on tissue expression from TISSUES for FMO5 Gene

  • Liver(4.6)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FMO5: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FMO5 Gene

Orthologs for FMO5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FMO5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FMO5 34 35
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia FMO5 34 35
  • 89.49 (n)
cow
(Bos Taurus)
Mammalia FMO5 34 35
  • 87.55 (n)
mouse
(Mus musculus)
Mammalia Fmo5 34 16 35
  • 84.24 (n)
rat
(Rattus norvegicus)
Mammalia Fmo5 34
  • 83.99 (n)
oppossum
(Monodelphis domestica)
Mammalia FMO5 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FMO5 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 67 (a)
OneToMany
LOC100857724 34
  • 65.91 (n)
-- 35
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 69 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fmo5 34 34 35
  • 63.65 (n)
si:dkey-239i20.2 35
  • 56 (a)
ManyToMany
si:dkey-239i20.4 35
  • 50 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Fmo-2 36 35
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea fmo-5 34 35
  • 51.68 (n)
fmo-13 36
  • 44 (a)
fmo-15 36
  • 44 (a)
fmo-3 35
  • 44 (a)
ManyToMany
fmo-11 36
  • 43 (a)
fmo-12 36
  • 43 (a)
fmo-14 36
  • 42 (a)
fmo-2 35
  • 42 (a)
ManyToMany
fmo-1 35
  • 41 (a)
ManyToMany
fmo-4 35
  • 37 (a)
ManyToMany
C01H6.4 36
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMO1 35
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
Species where no ortholog for FMO5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FMO5 Gene

ENSEMBL:
Gene Tree for FMO5 (if available)
TreeFam:
Gene Tree for FMO5 (if available)

Paralogs for FMO5 Gene

Paralogs for FMO5 Gene

(6) SIMAP similar genes for FMO5 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for FMO5 Gene

genes like me logo Genes that share paralogs with FMO5: view

Variants for FMO5 Gene

Sequence variations from dbSNP and Humsavar for FMO5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000027603 -- 147,195,799(+) TTTAC(C/G)TGATA intron-variant
rs1000169204 -- 147,200,794(+) GAAAT(A/G)TATGC intron-variant
rs1000336950 -- 147,214,706(+) TCCTC(C/T)GAGCT intron-variant
rs1000389533 -- 147,214,387(+) TGGAG(G/T)TTGCA intron-variant
rs1000683397 -- 147,207,956(+) TTCTA(A/C)GAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FMO5 Gene

Variant ID Type Subtype PubMed ID
dgv327n100 CNV gain 25217958
dgv66e199 CNV deletion 23128226
dgv67e199 CNV deletion 23128226
esv2761299 CNV gain+loss 21179565
esv3587435 CNV loss 21293372
nsv1003688 CNV gain 25217958
nsv1005055 CNV loss 25217958
nsv1077657 CNV deletion 25765185
nsv1121713 CNV deletion 24896259
nsv1132304 CNV duplication 24896259
nsv159869 CNV insertion 16902084
nsv437047 CNV loss 16327808
nsv509457 CNV insertion 20534489
nsv510962 OTHER complex 20534489
nsv547676 CNV gain 21841781
nsv946304 CNV duplication 23825009

Variation tolerance for FMO5 Gene

Residual Variation Intolerance Score: 82.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FMO5 Gene

Human Gene Mutation Database (HGMD)
FMO5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FMO5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FMO5 Gene

Disorders for FMO5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FMO5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
trimethylaminuria
  • fish malodor syndrome
atrioventricular septal defect
  • atrioventricular canal defect
- elite association - COSMIC cancer census association via MalaCards
Search FMO5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FMO5

Genetic Association Database (GAD)
FMO5
Human Genome Epidemiology (HuGE) Navigator
FMO5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FMO5
genes like me logo Genes that share disorders with FMO5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FMO5 Gene

Publications for FMO5 Gene

  1. Physical mapping of the human connexin 40 (GJA5), flavin-containing monooxygenase 5, and natriuretic peptide receptor a genes on 1q21. (PMID: 9119381) Gelb B.D. … Desnick R.J. (Genomics 1997) 2 3 22 64
  2. Localization of human flavin-containing monooxygenase genes FMO2 and FMO5 to chromosome 1q. (PMID: 8786146) McCombie R.R. … Shephard E.A. (Genomics 1996) 2 3 22 64
  3. Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog. (PMID: 7872795) Overby L.H. … Philpot R.M. (Arch. Biochem. Biophys. 1995) 3 4 22 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PMID: 19898482) Ross C.J. … Hayden M.R. (Nat. Genet. 2009) 3 46 64

Products for FMO5 Gene

Sources for FMO5 Gene

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