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Aliases for FMO4 Gene

Aliases for FMO4 Gene

  • Flavin Containing Monooxygenase 4 2 3 5
  • Hepatic Flavin-Containing Monooxygenase 4 3 4
  • Dimethylaniline Oxidase 4 3 4
  • EC 1.14.13.8 4 63
  • FMO 4 3 4
  • FMO2 3 4

External Ids for FMO4 Gene

Previous HGNC Symbols for FMO4 Gene

  • FMO2

Previous GeneCards Identifiers for FMO4 Gene

  • GC01P168847
  • GC01P166912
  • GC01P167864
  • GC01P168522
  • GC01P168015
  • GC01P169549
  • GC01P142506

Summaries for FMO4 Gene

Entrez Gene Summary for FMO4 Gene

  • Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]

GeneCards Summary for FMO4 Gene

FMO4 (Flavin Containing Monooxygenase 4) is a Protein Coding gene. Diseases associated with FMO4 include trimethylaminuria. Among its related pathways are Metabolism of xenobiotics by cytochrome P450 and Busulfan Pathway, Pharmacodynamics. GO annotations related to this gene include oxidoreductase activity and NADP binding. An important paralog of this gene is FMO2.

UniProtKB/Swiss-Prot for FMO4 Gene

  • This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.

Gene Wiki entry for FMO4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FMO4 Gene

Genomics for FMO4 Gene

Regulatory Elements for FMO4 Gene

Enhancers for FMO4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FMO4 on UCSC Golden Path with GeneCards custom track

Promoters for FMO4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FMO4 on UCSC Golden Path with GeneCards custom track

Genomic Location for FMO4 Gene

Chromosome:
1
Start:
171,314,137 bp from pter
End:
171,342,084 bp from pter
Size:
27,948 bases
Orientation:
Plus strand

Genomic View for FMO4 Gene

Genes around FMO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FMO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FMO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMO4 Gene

Proteins for FMO4 Gene

  • Protein details for FMO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31512-FMO4_HUMAN
    Recommended name:
    Dimethylaniline monooxygenase [N-oxide-forming] 4
    Protein Accession:
    P31512
    Secondary Accessions:
    • Q53XR0

    Protein attributes for FMO4 Gene

    Size:
    558 amino acids
    Molecular mass:
    63343 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

neXtProt entry for FMO4 Gene

Proteomics data for FMO4 Gene at MOPED

Post-translational modifications for FMO4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FMO4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for FMO4 Gene

Suggested Antigen Peptide Sequences for FMO4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31512

UniProtKB/Swiss-Prot:

FMO4_HUMAN :
  • Belongs to the FMO family.
Family:
  • Belongs to the FMO family.
genes like me logo Genes that share domains with FMO4: view

No data available for Gene Families for FMO4 Gene

Function for FMO4 Gene

Molecular function for FMO4 Gene

GENATLAS Biochemistry:
flavin containing monooxygenase 4,microsomal
UniProtKB/Swiss-Prot CatalyticActivity:
N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot Function:
This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.

Enzyme Numbers (IUBMB) for FMO4 Gene

Gene Ontology (GO) - Molecular Function for FMO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050661 NADP binding IEA --
genes like me logo Genes that share ontologies with FMO4: view
genes like me logo Genes that share phenotypes with FMO4: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FMO4 Gene

Localization for FMO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMO4 Gene

Microsome membrane. Endoplasmic reticulum membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FMO4 Gene COMPARTMENTS Subcellular localization image for FMO4 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
peroxisome 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for FMO4 Gene

Pathways & Interactions for FMO4 Gene

genes like me logo Genes that share pathways with FMO4: view

Pathways by source for FMO4 Gene

1 PharmGKB pathway for FMO4 Gene
1 KEGG pathway for FMO4 Gene

Gene Ontology (GO) - Biological Process for FMO4 Gene

None

No data available for SIGNOR curated interactions for FMO4 Gene

Drugs & Compounds for FMO4 Gene

(2) Drugs for FMO4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Tamoxifen Approved Pharma Antagonist ER antagonist, Anti-Estrogens 364

(10) Additional Compounds for FMO4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dimethylaniline-N-oxide
  • Dimethyl(phenyl)amine oxide
  • Dimethylaniline N-oxide
  • N,N-Dimethylaniline N-oxide
  • Nn-dimethylaniline-N-oxide
874-52-2
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
N,N-Dimethylaniline
  • Dimethylaminobenzene
  • Dimethylaniline
  • Dimethylphenylamine
  • N,N-(Dimethylamino)benzene
  • N,N-Dimethyl-Benzenamine
121-69-7
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with FMO4: view

Transcripts for FMO4 Gene

Unigene Clusters for FMO4 Gene

Flavin containing monooxygenase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FMO4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - - - - -
SP2: -
SP3:

Relevant External Links for FMO4 Gene

GeneLoc Exon Structure for
FMO4
ECgene alternative splicing isoforms for
FMO4

Expression for FMO4 Gene

mRNA expression in normal human tissues for FMO4 Gene

mRNA differential expression in normal tissues according to GTEx for FMO4 Gene

This gene is overexpressed in Liver (x6.7).

Protein differential expression in normal tissues from HIPED for FMO4 Gene

This gene is overexpressed in Gallbladder (42.3), Liver (19.2), and Kidney (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FMO4 Gene



SOURCE GeneReport for Unigene cluster for FMO4 Gene Hs.386502

mRNA Expression by UniProt/SwissProt for FMO4 Gene

P31512-FMO4_HUMAN
Tissue specificity: Liver.
genes like me logo Genes that share expression patterns with FMO4: view

Protein tissue co-expression partners for FMO4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FMO4 Gene

Orthologs for FMO4 Gene

This gene was present in the common ancestor of animals.

Orthologs for FMO4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FMO4 35
  • 87.76 (n)
  • 86 (a)
FMO4 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FMO4 35
  • 88.05 (n)
  • 86.49 (a)
FMO4 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fmo4 35
  • 83.21 (n)
  • 80.69 (a)
Fmo4 16
Fmo4 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FMO4 35
  • 99.52 (n)
  • 99.46 (a)
FMO4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fmo4 35
  • 82.61 (n)
  • 80.87 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia FMO4 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves FMO4 35
  • 59.31 (n)
  • 55.66 (a)
FMO4 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FMO4 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fmo1 35
  • 59.81 (n)
  • 52.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fmo-1 37
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea C01H6.4 37
  • 35 (a)
fmo-11 37
  • 39 (a)
fmo-13 37
  • 40 (a)
fmo-15 37
  • 42 (a)
Species with no ortholog for FMO4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for FMO4 Gene

ENSEMBL:
Gene Tree for FMO4 (if available)
TreeFam:
Gene Tree for FMO4 (if available)

Paralogs for FMO4 Gene

Paralogs for FMO4 Gene

(6) SIMAP similar genes for FMO4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FMO4 Gene

genes like me logo Genes that share paralogs with FMO4: view

Variants for FMO4 Gene

Sequence variations from dbSNP and Humsavar for FMO4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_015367 -
rs1042767 - 171,334,551(+) TGATG(C/T)TGTGA intron-variant, reference, missense
rs61342270 - 171,334,598(+) TTGAA(C/G)AACCT intron-variant, reference, missense, splice-acceptor-variant
rs45599742 - 171,334,697(+) TTATC(A/G)GCCTT intron-variant, downstream-variant-500B, reference, missense
VAR_022306 -

Structural Variations from Database of Genomic Variants (DGV) for FMO4 Gene

Variant ID Type Subtype PubMed ID
esv28731 CNV Gain+Loss 19812545
nsv831882 CNV Loss 17160897
nsv527149 CNV Gain 19592680

Variation tolerance for FMO4 Gene

Residual Variation Intolerance Score: 83.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FMO4 Gene

HapMap Linkage Disequilibrium report
FMO4
Human Gene Mutation Database (HGMD)
FMO4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FMO4 Gene

Disorders for FMO4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FMO4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
trimethylaminuria
  • fish odor syndrome
- elite association - COSMIC cancer census association via MalaCards
Search FMO4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FMO4

Genetic Association Database (GAD)
FMO4
Human Genome Epidemiology (HuGE) Navigator
FMO4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FMO4
genes like me logo Genes that share disorders with FMO4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FMO4 Gene

Publications for FMO4 Gene

  1. Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family. (PMID: 1417778) Dolphin C.T. … Phillips I.R. (Biochem. J. 1992) 3 4 23 67
  2. A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities. (PMID: 8311461) Lawton M.P. … Phillips I.R. (Arch. Biochem. Biophys. 1994) 2 3 23
  3. Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes. (PMID: 19307449) Novick R.M. … Elfarra A.A. (J. Pharmacol. Exp. Ther. 2009) 3 23
  4. Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. (PMID: 12527699) Furnes B. … Schlenk D. (Drug Metab. Dispos. 2003) 3 23
  5. Expression and characterization of a modified flavin-containing monooxygenase 4 from humans. (PMID: 8702731) Itagaki K. … Philpot R.M. (J. Biol. Chem. 1996) 3 23

Products for FMO4 Gene

Sources for FMO4 Gene

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