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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FMO4 Gene

protein-coding   GIFtS: 60
GCID: GC01P171283

Flavin Containing Monooxygenase 4


(Previous symbol: FMO2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Flavin Containing Monooxygenase 41 2     FMO 42 3
FMO21 2 3     EC 1.14.13.83 8
Dimethylaniline Oxidase 42 3     Dimethylaniline Monooxygenase [N-Oxide-Forming] 42
Hepatic Flavin-Containing Monooxygenase 42 3     

External Ids:    HGNC: 37721   Entrez Gene: 23292   Ensembl: ENSG000000762587   OMIM: 1361315   UniProtKB: P315123   

Export aliases for FMO4 gene to outside databases

Previous GC identifers: GC01P168847 GC01P166912 GC01P167864 GC01P168522 GC01P168015 GC01P169549 GC01P142506


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FMO4 Gene:
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing
monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with
reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme,
FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25
region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft
nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. (provided by RefSeq, Sep 2013)

GeneCards Summary for FMO4 Gene: 
FMO4 (flavin containing monooxygenase 4) is a protein-coding gene. Diseases associated with FMO4 include plasma cell neoplasm, and trimethylaminuria, and among its related super-pathways are Metabolism of xenobiotics by cytochrome P450 and FMO oxidizes nucleophiles. GO annotations related to this gene include flavin adenine dinucleotide binding and N,N-dimethylaniline monooxygenase activity. An important paralog of this gene is FMO2.

UniProtKB/Swiss-Prot: FMO4_HUMAN, P31512
Function: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and
pesticides

Gene Wiki entry for FMO4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FMO4 gene promoter:
         Pbx1a   HTF   POU3F1   HNF-4alpha2   STAT5A   GATA-1   Evi-1   POU2F1   COMP1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFMO4 promoter sequence
   Search SABiosciences Chromatin IP Primers for FMO4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FMO4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.3   Ensembl cytogenetic band:  1q24.3   HGNC cytogenetic band: 1q24.3

FMO4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FMO4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P171283:  view genomic region     (about GC identifiers)

Start:
171,283,347 bp from pter      End:
171,311,223 bp from pter
Size:
27,877 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FMO4_HUMAN, P31512 (See protein sequence)
Recommended Name: Dimethylaniline monooxygenase [N-oxide-forming] 4  
Size: 558 amino acids; 63343 Da
Cofactor: FAD
Subcellular location: Microsome membrane. Endoplasmic reticulum membrane
Caution: Was originally (PubMed:1417778) termed FMO2
Secondary accessions: Q53XR0

Explore the universe of human proteins at neXtProt for FMO4: NX_P31512

Explore proteomics data for FMO4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P31512

  • 4/17 DME Specific Peptides for FMO4 (P31512) (see all 17)
     EFTETSA  FDLLKYI  CFERSDD  AVFDAVM 

    FMO4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FMO4 Protein Expression
    REFSEQ proteins: NP_002013.1  
    ENSEMBL proteins: 
     ENSP00000356723  

    Human Recombinant Protein Products for FMO4: 
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    Cloud-Clone Corp. Proteins for FMO4 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--
    GO:0031227intrinsic to endoplasmic reticulum membrane ----
    GO:0043231intracellular membrane-bounded organelle NAS--

    FMO4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR020946 Flavin_mOase-like
     IPR012143 DiMe-aniline_mOase
     IPR000960 Flavin_mOase
     IPR002256 Flavin_mOase_4

    Graphical View of Domain Structure for InterPro Entry P31512

    ProtoNet protein and cluster: P31512

    3 Blocks protein domains:
    IPB000960 Flavin-containing monooxygenase (FMO) signature
    IPB001327 Pyridine nucleotide-disulphide oxidoreductase
    IPB002256 Flavin-containing monooxygenase (FMO) 4 signature


    UniProtKB/Swiss-Prot: FMO4_HUMAN, P31512
    Similarity: Belongs to the FMO family


    FMO4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FMO4_HUMAN, P31512
    Function: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and
    pesticides
    Catalytic activity: N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O

         Genatlas biochemistry entry for FMO4:
    flavin containing monooxygenase 4,microsomal

         Enzyme Number (IUBMB): EC 1.14.13.81 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004499N,N-dimethylaniline monooxygenase activity NAS1417778
    GO:0016491oxidoreductase activity ----
    GO:0050660flavin adenine dinucleotide binding IEA--
    GO:0050661NADP binding IEA--
         
    FMO4 for ontologies           About GeneDecksing


    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FMO4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Drug metabolism - cytochrome P450
    Drug metabolism - cytochrome P4500.73
    2Catalytic cycle of mammalian FMOs
    Catalytic cycle of mammalian FMOs0.60
    3Biological oxidations
    metapathway biotransformation0.41
    4Busulfan Pathway, Pharmacodynamics
    Busulfan Pathway, Pharmacodynamics

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for FMO4
        Catalytic cycle of mammalian FMOs
    metapathway biotransformation

    1 PharmGKB Pathway for FMO4
        Busulfan Pathway, Pharmacodynamics

    1         Kegg Pathway  (Kegg details for FMO4):
        Drug metabolism - cytochrome P450


    FMO4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FMO4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/11 Interacting proteins for FMO4 (P315123 ENSP000003567234) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TLN1Q9Y4903I2D: score=1 
    CYP2D6ENSP000003538204STRING: ENSP00000353820
    CYP3A4ENSP000003379154STRING: ENSP00000337915
    CYP3A43ENSP000002223824STRING: ENSP00000222382
    CYP3A5ENSP000002229824STRING: ENSP00000222982
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process NAS--
    GO:0055114oxidation-reduction process ----

    FMO4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FMO4

    7 HMDB Compounds for FMO4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dimethylaniline-N-oxideDimethylaniline N-oxide (see all 4)874-52-2--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    N,N-DimethylanilineDimethylaminobenzene (see all 9)121-69-7--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about FMO4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FMO4 gene: 
    NM_002022.1  

    Unigene Cluster for FMO4:

    Flavin containing monooxygenase 4
    Hs.386502  [show with all ESTs]
    Unigene Representative Sequence: BC002780
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497228 ENST00000475780 ENST00000367749(uc001gho.3) ENST00000462992
    ENST00000480136
    miRNA
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    hsa-miR-1270 hsa-miR-620
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    Inhib. RNA
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    Additional mRNA sequence: 

    BC002780.2 BT007444.1 Z11737.1 

    3 DOTS entries:

    DT.308646  DT.95360330  DT.91742494 

    24/35 AceView cDNA sequences (see all 35):

    BQ722317 BE218037 BM980825 BU741690 BE218261 H40148 BC002780 NM_002022 
    Z11737 BF114975 BX110484 N42801 BF431685 AI291725 BX481672 BG568174 
    BX495448 BG036813 CA306589 BT007444 BG573059 BM724433 BM979122 AW340441 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FMO4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:                          -     -     -     -     -               
    SP2:                                            -                     
    SP3:                                                                  


    ECgene alternative splicing isoforms for FMO4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FMO4 expression in normal human tissues (normalized intensities)      FMO4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAATTCTAT
    FMO4 Expression
    About this image


    FMO4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Primitive gut tube-like cells ( A scalable, suspension protocol for derivation of...
     
     Liver (Hepatobiliary System)
     
     Kidney (Urinary System)

    See FMO4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FMO4

    SOURCE GeneReport for Unigene cluster: Hs.386502

    UniProtKB/Swiss-Prot: FMO4_HUMAN, P31512
    Tissue specificity: Liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including FMO4: 
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              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMO4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FMO4 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fmo41 , 5 flavin containing monooxygenase 41, 5 83.21(n)1
    80.69(a)1
      1 (70.34 cM)5
    2265641  NM_144878.11  NP_659127.11 
     1627938835 
    chicken
    (Gallus gallus)
    Aves FMO41 flavin containing monooxygenase 4 59.73(n)
    56.11(a)
      770587  XM_001233923.2  XP_001233924.2 
    lizard
    (Anolis carolinensis)
    Reptilia FMO46
    Dimethylaniline monooxygenase [N-oxide-forming]
    54(a)
    1 ↔ 1
    GL343959.1(53352-72644)
    zebrafish
    (Danio rerio)
    Actinopterygii fmo56
    si:dkey-239i20.26
    (see all 3)
    si:dkey-239i20.2
    (see all 3)
    51(a)
    50(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    20(15099468-15110570)
    20(15090312-15096721)
    worm
    (Caenorhabditis elegans)
    Secernentea fmo-153 flavin-containing monooxygenase 42(a)
    (best of 4)
      V(899210-903377)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FMO16
    Flavin-containing monooxygenase, localized to the ...
    27(a)
    1 → many
    VIII(454229-455527)


    ENSEMBL Gene Tree for FMO4 (if available)
    TreeFam Gene Tree for FMO4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FMO4 gene
    FMO22  FMO32  FMO52  FMO6P2  FMO12  
    6 SIMAP similar genes for FMO4 using alignment to 1 protein entry:     FMO4_HUMAN:
    FMO5    DKFZp667E137    FMO2    FMO6P    FMO1    FMO3

    FMO4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FMO4
    PGOHUM00000251141


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/610 SNPs in FMO4 are shown (see all 610)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0153674
    ----see VAR_0153672 I T mis40--------
    VAR_0223074
    ----see VAR_0223072 L R mis40--------
    rs1143097871,2
    F--142504634(+) CATTGC/TGCAAT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1827488071,2
    --142504651(+) AAGCAA/GTTGGG 1 -- us2k10--------
    rs1875157721,2
    C--142504659(+) GGGGTA/GTCCTG 1 -- us2k10--------
    rs1929475241,2
    --142504672(+) TAAAGG/TGGGTA 1 -- us2k10--------
    rs1828180911,2
    --142504907(+) CAATCG/TTGGGG 1 -- us2k10--------
    rs1873962991,2
    --142504936(+) TTCTGA/GTAAGA 1 -- us2k10--------
    rs454831051,2
    C,F--142504992(+) CCCAGC/ACAGCG 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs455475351,2
    C--142505134(+) CCGCAG/TCTCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FMO4 (171283347 - 171311223 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FMO4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831882CNV Loss17160897
    nsv527149CNV Gain19592680
    esv28731CNV Gain+Loss19812545


    Human Gene Mutation Database (HGMD): FMO4
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 136131    OMIM disorders: --

    5 diseases for FMO4:    About MalaCards
    plasma cell neoplasm    trimethylaminuria    hepatitis    prader-willi syndrome
    cytochrome p450


    FMO4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FMO4
    Human Genome Epidemiology (HuGE) Navigator: FMO4 (2 documents)

    Export disorders for FMO4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FMO4 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with FMO4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family. (PubMed id 1417778)1, 2, 9 Dolphin C.T.... Phillips I.R. (1992)
    2. A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities. (PubMed id 8311461)1, 3, 9 Lawton M.P....Phillips I.R. (1994)
    3. Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. (PubMed id 12527699)1, 2, 9 Furnes B.... Schlenk D. (2003)
    4. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1, 4 Ross C.J....Hayden M.R. (2009)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Expression and characterization of a modified flavin-containing monooxygenase 4 from humans. (PubMed id 8702731)1, 9 Itagaki K....Philpot R.M. (1996)
    8. Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes. (PubMed id 19307449)1, 9 Novick R.M....Elfarra A.A. (2009)
    9. Evaluation of candidate genes for cholinesterase acti vity in farmworkers exposed to organophosphorus pesticides: association of sing le nucleotide polymorphisms in BCHE. (PubMed id 20529763)1 Howard T.D....Arcury T.A. (2010)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2329 HGNC: 3772 AceView: FMO4 Ensembl:ENSG00000076258 euGenes: HUgn2329
    ECgene: FMO4 Kegg: 2329 H-InvDB: FMO4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FMO4 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fmo4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FMO4 gene:
    Search GeneIP for patents involving FMO4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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