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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FMO3 Gene

protein-coding   GIFtS: 68
GCID: GC01P171060

Flavin Containing Monooxygenase 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Flavin Containing Monooxygenase 31 2     EC 1.14.13.83 8
Dimethylaniline Oxidase 32 3     TMAU2 5
Hepatic Flavin-Containing Monooxygenase 32 3     FMOII2
Trimethylamine Monooxygenase2 3     dJ127D3.12
FMO 32 3     Dimethylaniline Monooxygenase [N-Oxide-Forming] 32
FMO Form 22 3     Hepatic Flavin-Containing Monooxygenase-32
FMO II2 3     EC 1.14.13.1483

External Ids:    HGNC: 37711   Entrez Gene: 23282   Ensembl: ENSG000000079337   OMIM: 1361325   UniProtKB: P315133   

Export aliases for FMO3 gene to outside databases

Previous GC identifers: GC01P168623 GC01P166689 GC0XP9N0049 GC01P168299 GC01P167791 GC01P169326 GC01P142283


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FMO3 Gene:
Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the
NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as
therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is
composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific
expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to
20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have
significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest
to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many
tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.
Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and
excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is
primarily converted to the non odorous trimethylamine N-oxide.(provided by RefSeq, Aug 2009)

GeneCards Summary for FMO3 Gene: 
FMO3 (flavin containing monooxygenase 3) is a protein-coding gene. Diseases associated with FMO3 include trimethylaminuria, and hepatitis, and among its related super-pathways are Tamoxifen Pathway, Pharmacokinetics and Nicotine metabolism. GO annotations related to this gene include amino acid binding and flavin adenine dinucleotide binding. An important paralog of this gene is FMO2.

UniProtKB/Swiss-Prot: FMO3_HUMAN, P31513
Function: Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It
N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in
the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform
S-oxidation when acting on sulfide compounds

Gene Wiki entry for FMO3 (Flavin containing monooxygenase 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FMO3 gene promoter:
         Max1   USF1   Pbx1a   HNF-1A   C/EBPalpha   RORalpha2   Gfi-1   HNF-1   USF-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFMO3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FMO3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FMO3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.3   Ensembl cytogenetic band:  1q24.3   HGNC cytogenetic band: 1q24.3

FMO3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FMO3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P171060:  view genomic region     (about GC identifiers)

Start:
171,060,018 bp from pter      End:
171,086,959 bp from pter
Size:
26,942 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FMO3_HUMAN, P31513 (See protein sequence)
Recommended Name: Dimethylaniline monooxygenase [N-oxide-forming] 3  
Size: 532 amino acids; 60033 Da
Cofactor: FAD
Subcellular location: Microsome membrane. Endoplasmic reticulum membrane
Secondary accessions: B2R816 Q14854 Q8N5N5

Explore the universe of human proteins at neXtProt for FMO3: NX_P31513

Explore proteomics data for FMO3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P31513

  • 4/23 DME Specific Peptides for FMO3 (P31513) (see all 23)
     EFTETSA  FATGYSF  AVFDAVM  SKEMMCF 

    FMO3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FMO3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001002294.1  NP_008825.4  

    ENSEMBL proteins: 
     ENSP00000356729   ENSP00000375935   ENSP00000439500   ENSP00000444073  
    Reactome Protein details: P31513
    Human Recombinant Protein Products for FMO3: 
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    Novus Biologicals FMO3 Protein
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FMO3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0031227intrinsic to endoplasmic reticulum membrane ----
    GO:0043231intracellular membrane-bounded organelle TAS9207220

    FMO3 for ontologies           About GeneDecksing



    FMO3 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR020946 Flavin_mOase-like
     IPR012143 DiMe-aniline_mOase
     IPR002255 Flavin_mOase_3
     IPR000960 Flavin_mOase

    Graphical View of Domain Structure for InterPro Entry P31513

    ProtoNet protein and cluster: P31513

    3 Blocks protein domains:
    IPB000960 Flavin-containing monooxygenase (FMO) signature
    IPB001327 Pyridine nucleotide-disulphide oxidoreductase
    IPB002255 Flavin-containing monooxygenase (FMO) 3 signature


    UniProtKB/Swiss-Prot: FMO3_HUMAN, P31513
    Similarity: Belongs to the FMO family


    FMO3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FMO3_HUMAN, P31513
    Function: Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It
    N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in
    the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform
    S-oxidation when acting on sulfide compounds
    Catalytic activity: N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O
    Catalytic activity: N,N,N-trimethylamine + NADPH + O(2) = N,N,N-trimethylamine N-oxide + NADP(+) + H(2)O
    Biophysicochemical properties: Kinetic parameters: KM=21 uM for trimethylamine (at pH 8.5); KM=31 uM for
    trimethylamine (at pH 7.4 and 37 degrees Celsius); KM=43 uM for benzydamine (at pH 7.4 and 37 degrees Celsius);
    KM=55.7 uM for ethylenethiourea (at pH 8.5); KM=71.8 uM for methimazole (at pH 8.5); KM=150.1 uM for sulindac (at
    pH 8.5); KM=248 uM for methyl p-tolyl sulfide (at pH 7.4 and 37 degrees Celsius);

         Genatlas biochemistry entry for FMO3:
    flavin containing monooxygenase 3,microsomal,major hepatic form

         Enzyme Numbers (IUBMB): EC 1.14.13.81 2 EC 1.14.13.1481

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004499N,N-dimethylaniline monooxygenase activity TAS--
    GO:0016491oxidoreductase activity ----
    GO:0016597amino acid binding IEA--
    GO:0034899trimethylamine monooxygenase activity IEA--
    GO:0050660flavin adenine dinucleotide binding IEA--
         
    FMO3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FMO3:
     Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FMO3 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FMO3 
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate FMO3:
    hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidFMO3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FMO3 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Tamoxifen metabolism
    Tamoxifen metabolism0.68
    Tamoxifen Pathway, Pharmacokinetics0.68
    2Nicotine Pathway, Pharmacokinetics
    Nicotine Pathway, Pharmacokinetics0.60
    Nicotine metabolism0.60
    3Catalytic cycle of mammalian FMOs
    FMO oxidizes nucleophiles0.60
    Catalytic cycle of mammalian FMOs0.60
    4Biological oxidations
    Biological oxidations0.55
    metapathway biotransformation0.41
    5Cytochrome P450 - arranged by substrate type
    Phase 1 - Functionalization of compounds0.74

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/6 BioSystems Pathways for FMO3 (see all 6)
        Catalytic cycle of mammalian FMOs
    SIDS Susceptibility Pathways
    nicotine degradation IV
    Tamoxifen metabolism
    Nicotine metabolism


    4        Reactome Pathways for FMO3
        Metabolism
    Biological oxidations
    Phase 1 - Functionalization of compounds
    FMO oxidizes nucleophiles

    3 PharmGKB Pathways for FMO3
        Busulfan Pathway, Pharmacodynamics
    Nicotine Pathway, Pharmacokinetics
    Tamoxifen Pathway, Pharmacokinetics

    1         Kegg Pathway  (Kegg details for FMO3):
        Drug metabolism - cytochrome P450


    FMO3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FMO3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/10 Interacting proteins for FMO3 (ENSP000003567294) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYP2D6ENSP000003538204STRING: ENSP00000353820
    CYP3A4ENSP000003379154STRING: ENSP00000337915
    CYP3A43ENSP000002223824STRING: ENSP00000222382
    CYP3A5ENSP000002229824STRING: ENSP00000222982
    CYP3A7ENSP000003374504STRING: ENSP00000337450
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0017144drug metabolic process IEA--
    GO:0044281small molecule metabolic process TAS--
    GO:0055114oxidation-reduction process ----

    FMO3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FMO3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FMO3

    9 HMDB Compounds for FMO3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dimethylaniline-N-oxideDimethylaniline N-oxide (see all 4)874-52-2--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    N,N-DimethylanilineDimethylaminobenzene (see all 9)121-69-7--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    OxygenOxygen (see all 5)7782-44-7--
    SulfideSulfide (see all 4)18496-25-8--
    TrimethylamineDimethylmethaneamine (see all 6)75-50-3--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    9 DrugBank Compounds for FMO3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cimetidine-- 51481-61-9enzymesubstrate19283698 11465082 7720103
    Almotriptan-- 181183-52-8enzymesubstrate12642466
    Clozapine-- 5786-21-0enzymesubstrate19515014
    Dapsone1,1'-Sulfonylbis[4-aminobenzene] (see all 8)80-08-0enzymesubstrate19515014
    Dasatinib-- 302962-49-8enzymesubstrate18556438
    Olanzapine-- 132539-06-1enzymesubstrate10511917
    TamoxifenICI-46474 (see all 3)10540-29-1enzymesubstrate19515014
    Voriconazole-- 137234-62-9enzymesubstrate19515014
    Vandetanib4-quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]- (see all 4)443913-73-3enzymesubstrate--

    10/30 Novoseek inferred chemical compound relationships for FMO3 gene (see all 30)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methyl p-tolyl sulfide 90.2 6 17942081 (1), 12695352 (1), 17142560 (1), 19571433 (1)
    benzydamine 85.7 9 11012553 (4), 15564885 (2), 17142560 (1), 19571433 (1)
    sulindac sulfide 83.7 8 10807940 (1), 17559352 (1), 16214918 (1), 19321370 (1) (see all 5)
    tmao 83 16 9776311 (2), 17531949 (1), 19881207 (1), 11465082 (1) (see all 9)
    methimazole 81.7 7 12814961 (2), 11414682 (1), 9344459 (1), 17942081 (1)
    thiobenzamide 80.4 1 15363661 (1)
    s-(1,2-dichlorovinyl)-l-cysteine 73.1 2 17892265 (1), 9884308 (1)
    n-octylamine 72.7 2 9750169 (1)
    flavin 71.4 14 15623613 (1), 17302959 (1), 14709624 (1), 16214918 (1) (see all 12)
    bufuralol 66.3 1 11038163 (1)

    Search CenterWatch for drugs/clinical trials and news about FMO3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FMO3 gene (2 alternative transcripts): 
    NM_001002294.2  NM_006894.5  

    Unigene Cluster for FMO3:

    Flavin containing monooxygenase 3
    Hs.445350  [show with all ESTs]
    Unigene Representative Sequence: AK223166
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367755(uc001ghi.3 uc001ghh.3 uc010pmb.2 uc010pmc.2)
    ENST00000530212(uc010pma.1) ENST00000534514 ENST00000472784 ENST00000479749
    ENST00000478457 ENST00000392085 ENST00000538429 ENST00000542847
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FMO3

    Additional mRNA sequence: 

    AK223166.1 AK296105.1 AK298406.1 AK298456.1 AK310785.1 AK313197.1 BC032016.1 M83772.1 
    Z47552.1 

    12 DOTS entries:

    DT.95166654  DT.413620  DT.92431685  DT.95166656  DT.92431687  DT.92431683  DT.99972987  DT.92042899 
    DT.92431692  DT.100767373  DT.92431689  DT.95166657 

    24/86 AceView cDNA sequences (see all 86):

    H71848 NM_006894 BU625130 BM989135 BI758833 AV688561 AV654417 NM_001002294 
    T95250 AU100084 CA395462 BC032016 AV648086 AU107182 AI052149 AV699326 
    AV652829 AV648072 H37985 BI756793 BI819385 AI300119 AV697859 AV654003 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FMO3    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
    SP1:                                -     -                                   -                     
    SP2:                    -           -     -                                   -                     
    SP3:                    -                                                                           
    SP4:                                                                                                


    ECgene alternative splicing isoforms for FMO3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FMO3 expression in normal human tissues (normalized intensities)      FMO3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTCCTTTTT
    FMO3 Expression
    About this image


    FMO3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
             Human Trabecular Meshwork Cells (HTMC)   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Human Annulus Fibrosus Cells (HAFC)   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem Progenitor EN7
     
     Smooth Muscle (Muscoskeletal System)
             Human Tracheal Smooth Muscle Cells (HTSMC)   
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor

    See FMO3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FMO3

    SOURCE GeneReport for Unigene cluster: Hs.445350

    UniProtKB/Swiss-Prot: FMO3_HUMAN, P31513
    Tissue specificity: Liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including FMO3: 
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              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FMO3 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fmo31 , 5 flavin containing monooxygenase 31, 5 83.11(n)1
    79.66(a)1
      1 (70.34 cM)5
    142621  NM_008030.11  NP_032056.11 
     1629538025 
    chicken
    (Gallus gallus)
    Aves FMO6P6
    flavin containing monooxygenase 6 pseudogene
    61(a)
    1 → many
    8(4792393-4800086)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Dimethylaniline monooxygenase [N-oxide-forming]
    74(a)
    69(a)
    many ↔ many
    many ↔ many
    AAWZ02037914(2376-13155)
    GL343300.1(1575512-1596183)
    zebrafish
    (Danio rerio)
    Actinopterygii fmo56
    si:dkey-239i20.26
    (see all 3)
    si:dkey-239i20.2
    (see all 3)
    50(a)
    49(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    20(15099468-15110570)
    20(15090312-15096721)
    worm
    (Caenorhabditis elegans)
    Secernentea fmo-133 DIMETHYLANILINE MONOOXYGENASE (N-OXIDE
    FORMING) more
    42(a)
    (best of 6)
      III(10766342-10770439)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FMO16
    Flavin-containing monooxygenase, localized to the ...
    27(a)
    1 → many
    VIII(454229-455527)


    ENSEMBL Gene Tree for FMO3 (if available)
    TreeFam Gene Tree for FMO3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FMO3 gene
    FMO22  FMO42  FMO52  FMO6P2  FMO12  
    6 SIMAP similar genes for FMO3 using alignment to 3 protein entries:     FMO3_HUMAN (see all proteins):
    FMO6P    DKFZp667E137    FMO2    FMO1    FMO4    FMO5

    FMO3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/807 SNPs in FMO3 are shown (see all 807)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0373084
    Trimethylaminuria (TMAU)4--see VAR_0373082 M I mis40--------
    VAR_0081454
    Trimethylaminuria (TMAU)4--see VAR_0081452 R W mis40--------
    VAR_0373064
    Trimethylaminuria (TMAU)4--see VAR_0373062 E K mis40--------
    VAR_0373074
    Trimethylaminuria (TMAU)4--see VAR_0373072 N S mis40--------
    VAR_0081464
    Trimethylaminuria (TMAU)4--see VAR_0081462 A T mis40--------
    VAR_0024234
    Trimethylaminuria (TMAU)4--see VAR_0024232 M I mis40--------
    VAR_0024244
    Trimethylaminuria (TMAU)4--see VAR_0024242 P L mis40--------
    rs725493311,2,4
    CTrimethylaminuria (TMAU)4 pathogenic1177636044(+) GTCCCA/G/TCTGGG 4 R L mis11NA 3560
    rs725493201,2
    Cpathogenic1177614455(+) GCTTTA/GAGAAG 4 K E mis10--------
    rs725493211,2
    Cpathogenic1177625511(+) GCAGGA/GCTAGC 4 T A mis10--------

    HapMap Linkage Disequilibrium report for FMO3 (171060018 - 171086959 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FMO3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv28731CNV Gain+Loss19812545


    Human Gene Mutation Database (HGMD): FMO3

    Locus Specific Mutation Databases (LSDB): FMO3
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 136132   
    OMIM disorders: 602079  
    UniProtKB/Swiss-Prot: FMO3_HUMAN, P31513
  • Trimethylaminuria (TMAU) [MIM:602079]: Inborn error of metabolism associated with an offensive body odor
    and caused by deficiency of FMO-mediated N-oxidation of amino-trimethylamine (TMA) derived from foodstuffs. Such
    individuals excrete relatively large amounts of TMA in their urine, sweat, and breath, and exhibit a fishy body
    odor characteristic of the malodorous free amine. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 12 diseases for FMO3:    About MalaCards
    trimethylaminuria    hepatitis    familial adenomatous polyposis    patent ductus arteriosus
    sudden infant death syndrome    metabolic disorders    cytochrome p450    essential hypertension
    hypertension    adenoma    schizophrenia    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for FMO3:
    Lymphocytic choriomeningitis

    FMO3 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for FMO3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trimethylaminuria 98.2 85 17584019 (4), 9282831 (4), 19881207 (3), 16601883 (3) (see all 31)
    metabolic disorder 40.6 6 17584019 (1), 17531949 (1), 17142560 (1)
    familial adenomatous polyposis 27.1 2 17559352 (1)
    polyposis 25.4 3 15623613 (2), 16214918 (1)
    adenoma 0 1 16214918 (1)

    GeneTests: FMO3
    GeneReviews: FMO3
    Genetic Association Database (GAD): FMO3
    Human Genome Epidemiology (HuGE) Navigator: FMO3 (23 documents)

    Export disorders for FMO3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FMO3 gene, integrated from 9 sources (see all 169):
    (articles sorted by number of sources associating them with FMO3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural organization of the human flavin-containing monooxygenase 3 gene (FMO3), the favored candidate for fish-odor syndrome, determined directly from genomic DNA. (PubMed id 9417913)1, 2, 3, 9 Dolphin C.T.... Phillips I.R. (1997)
    2. Genetic polymorphism of the flavin-containing monooxygenase 3 (FMO3) associated with trimethylaminuria (fish odor syndrome): observations from Japanese patients. (PubMed id 17584019)1, 4, 9 Yamazaki H. and Shimizu M. (2007)
    3. Two new polymorphisms of the FMO3 gene in Caucasian and African-American populations: comparative genetic and functional studies. (PubMed id 12814961)1, 4, 9 Lattard V....Cashman J.R. (2003)
    4. Population distribution of human flavin-containing monooxygenase form 3: gene polymorphisms. (PubMed id 11717182)1, 4, 9 Cashman J.R....Braun A. (2001)
    5. Compound heterozygosity for missense mutations in the flavin- containing monooxygenase 3 (FM03) gene in patients with fish-odour syndrome. (PubMed id 11191884)1, 2, 9 Dolphin C.T.... Phillips I.R. (2000)
    6. Analysis of flavin-containing monooxygenase 3 genotype data in populations administered the anti-schizophrenia agent olanzapine. (PubMed id 19356079)1, 4, 9 Cashman J.R....Braun A. (2008)
    7. Two novel single nucleotide polymorphisms (SNPs) of the FMO3 gene in Japanese. (PubMed id 15618753)1, 2, 9 Fujieda M.... Kamataki T. (2003)
    8. Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians. (PubMed id 16324215)1, 4, 9 Dolan C....Treacy E.P. (2005)
    9. [The frequency distribution of flavin-containing monooxygenase 3 mutant alleles in 28 populations from Yunnan] (PubMed id 12903042)1, 4, 9 Zeng W.M....Xiao C.J. (2003)
    10. Functional characterization of genetic variants of human FMO3 associated with trimethylaminuria. (PubMed id 17531949)1, 2, 9 Yeung C.K....Rettie A.E. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2328 HGNC: 3771 AceView: FMO3 Ensembl:ENSG00000007933 euGenes: HUgn2328
    ECgene: FMO3 Kegg: 2328 H-InvDB: FMO3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FMO3 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FMO3
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fmo3/
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt149.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FMO3 gene:
    Search GeneIP for patents involving FMO3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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