Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FMO3 Gene

protein-coding   GIFtS: 68
GCID: GC01P171060

Flavin Containing Monooxygenase 3

  See FMO3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Flavin Containing Monooxygenase 31 2     EC 1.14.13.83 8
Dimethylaniline Oxidase 32 3     TMAU2 5
Hepatic Flavin-Containing Monooxygenase 32 3     FMOII2
Trimethylamine Monooxygenase2 3     dJ127D3.12
FMO 32 3     Dimethylaniline Monooxygenase [N-Oxide-Forming] 32
FMO Form 22 3     Hepatic Flavin-Containing Monooxygenase-32
FMO II2 3     EC 1.14.13.1483

External Ids:    HGNC: 37711   Entrez Gene: 23282   Ensembl: ENSG000000079337   OMIM: 1361325   UniProtKB: P315133   

Export aliases for FMO3 gene to outside databases

Previous GC identifers: GC01P168623 GC01P166689 GC0XP9N0049 GC01P168299 GC01P167791 GC01P169326 GC01P142283


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FMO3 Gene:
Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the
NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as
therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is
composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific
expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to
20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have
significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest
to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many
tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.
Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and
excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is
primarily converted to the non odorous trimethylamine N-oxide.(provided by RefSeq, Aug 2009)

GeneCards Summary for FMO3 Gene:
FMO3 (flavin containing monooxygenase 3) is a protein-coding gene. Diseases associated with FMO3 include trimethylaminuria, and lymphocytic choriomeningitis. GO annotations related to this gene include amino acid binding and flavin adenine dinucleotide binding. An important paralog of this gene is FMO2.

UniProtKB/Swiss-Prot: FMO3_HUMAN, P31513
Function: Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It
N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in
the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform
S-oxidation when acting on sulfide compounds

Gene Wiki entry for FMO3 (Flavin containing monooxygenase 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FMO3 gene promoter:
         Max1   USF1   Pbx1a   HNF-1A   C/EBPalpha   RORalpha2   Gfi-1   HNF-1   USF-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFMO3 promoter sequence
   Search Chromatin IP Primers for FMO3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FMO3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.3   Ensembl cytogenetic band:  1q24.3   HGNC cytogenetic band: 1q24.3

FMO3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FMO3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P171060:  view genomic region     (about GC identifiers)

Start:
171,060,018 bp from pter      End:
171,086,959 bp from pter
Size:
26,942 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FMO3_HUMAN, P31513 (See protein sequence)
Recommended Name: Dimethylaniline monooxygenase [N-oxide-forming] 3  
Size: 532 amino acids; 60033 Da
Cofactor: FAD
Secondary accessions: B2R816 Q14854 Q8N5N5

Explore the universe of human proteins at neXtProt for FMO3: NX_P31513

Explore proteomics data for FMO3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FMO3 (P31513) (see all 23)
     EFTETSA  FATGYSF  AVFDAVM  SKEMMCF 


    See FMO3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001002294.1  NP_008825.4  

    ENSEMBL proteins: 
     ENSP00000356729   ENSP00000476963   ENSP00000477451   ENSP00000375935   ENSP00000439500  
     ENSP00000444073  
    Reactome Protein details: P31513

    FMO3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for FMO3
    OriGene Protein Over-expression Lysate for FMO3
    OriGene MassSpec for FMO3
    OriGene Custom Protein Services for FMO3
    GenScript Custom Purified and Recombinant Proteins Services for FMO3
    Novus Biologicals FMO3 Protein
    Novus Biologicals FMO3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FMO3

     
    Search eBioscience for Proteins for FMO3 

    FMO3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for FMO3
    OriGene Custom Antibody Services for FMO3
    Novus Biologicals FMO3 Antibodies
    Abcam antibodies for FMO3
    Cloud-Clone Corp. Antibodies for FMO3
    ThermoFisher Antibody for FMO3
    LSBio Antibodies in human, mouse, rat for FMO3

    FMO3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FMO3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FMO3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FMO3
    Cloud-Clone Corp. CLIAs for FMO3
    Search eBioscience for ELISAs for FMO3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR020946 Flavin_mOase-like
     IPR012143 DiMe-aniline_mOase
     IPR002255 Flavin_mOase_3
     IPR000960 Flavin_mOase

    Graphical View of Domain Structure for InterPro Entry P31513

    ProtoNet protein and cluster: P31513

    3 Blocks protein domains:
    IPB000960 Flavin-containing monooxygenase (FMO) signature
    IPB001327 Pyridine nucleotide-disulphide oxidoreductase
    IPB002255 Flavin-containing monooxygenase (FMO) 3 signature


    UniProtKB/Swiss-Prot: FMO3_HUMAN, P31513
    Similarity: Belongs to the FMO family


    Find genes that share domains with FMO3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FMO3_HUMAN, P31513
    Function: Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It
    N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in
    the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform
    S-oxidation when acting on sulfide compounds
    Catalytic activity: N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O
    Catalytic activity: N,N,N-trimethylamine + NADPH + O(2) = N,N,N-trimethylamine N-oxide + NADP(+) + H(2)O
    Biophysicochemical properties: Kinetic parameters: KM=21 uM for trimethylamine (at pH 8.5); KM=31 uM for
    trimethylamine (at pH 7.4 and 37 degrees Celsius); KM=43 uM for benzydamine (at pH 7.4 and 37 degrees Celsius);
    KM=55.7 uM for ethylenethiourea (at pH 8.5); KM=71.8 uM for methimazole (at pH 8.5); KM=150.1 uM for sulindac (at
    pH 8.5); KM=248 uM for methyl p-tolyl sulfide (at pH 7.4 and 37 degrees Celsius);

         Genatlas biochemistry entry for FMO3:
    flavin containing monooxygenase 3,microsomal,major hepatic form

         Enzyme Numbers (IUBMB): EC 1.14.13.81 2 EC 1.14.13.1481

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004499N,N-dimethylaniline monooxygenase activity TAS--
    GO:0016491oxidoreductase activity ----
    GO:0016597amino acid binding IEA--
    GO:0034899trimethylamine monooxygenase activity IEA--
    GO:0050660flavin adenine dinucleotide binding IEA--
         
    Find genes that share ontologies with FMO3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FMO3:
     Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FMO3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FMO3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FMO3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FMO3

    miRNA
    Products:
        
    miRTarBase miRNAs that target FMO3:
    hsa-mir-26b-5p (MIRT030320)

    Block miRNA regulation of human, mouse, rat FMO3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate FMO3:
    hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidFMO3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FMO3
    Predesigned siRNA for gene silencing in human, mouse, rat FMO3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FMO3

    Clone
    Products:
         
    OriGene clones in human, mouse for FMO3 (see all 11)
    OriGene ORF clones in mouse, rat for FMO3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FMO3 (NM_001002294)
    Sino Biological Human cDNA Clone for FMO3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FMO3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FMO3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FMO3
    Browse ESI BIO Cell Lines and PureStem Progenitors for FMO3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMO3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FMO3_HUMAN, P31513: Microsome membrane. Endoplasmic reticulum membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol3
    plasma membrane3
    cytoskeleton1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0043231intracellular membrane-bounded organelle TAS9207220

    Find genes that share ontologies with FMO3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FMO3 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    Biological oxidations0.56
    Tamoxifen metabolism0.00
    metapathway biotransformation0.42
    Tamoxifen Pathway, Pharmacokinetics0.00
    2Busulfan Pathway, Pharmacodynamics
    Busulfan Pathway, Pharmacodynamics
    FMO oxidizes nucleophiles0.00
    Catalytic cycle of mammalian FMOs0.00
    3Nicotine Pathway, Pharmacokinetics
    Nicotine Pathway, Pharmacokinetics
    Nicotine metabolism0.00
    4Cytochrome P450 - arranged by substrate type
    Phase 1 - Functionalization of compounds0.75
    5Chemical carcinogenesis
    Drug metabolism - cytochrome P4500.69


    Find genes that share SuperPaths with FMO3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected BioSystems Pathways for FMO3 (see all 6)
        SIDS Susceptibility Pathways
    Catalytic cycle of mammalian FMOs
    nicotine degradation IV
    Tamoxifen metabolism
    Nicotine metabolism


    1 Reactome Pathway for FMO3
        FMO oxidizes nucleophiles

    3 PharmGKB Pathways for FMO3
        Busulfan Pathway, Pharmacodynamics
    Nicotine Pathway, Pharmacokinetics
    Tamoxifen Pathway, Pharmacokinetics

    1 Kegg Pathway  (Kegg details for FMO3):
        Drug metabolism - cytochrome P450

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FMO3: 
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FMO3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for FMO3 (ENSP000003567294) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYP2D6ENSP000003538204STRING: ENSP00000353820
    CYP3A4ENSP000003379154STRING: ENSP00000337915
    CYP3A43ENSP000002223824STRING: ENSP00000222382
    CYP3A5ENSP000002229824STRING: ENSP00000222982
    CYP3A7ENSP000003374504STRING: ENSP00000337450
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0017144drug metabolic process IEA--
    GO:0044281small molecule metabolic process TAS--
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with FMO3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FMO3

    9 HMDB Compounds for FMO3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dimethylaniline-N-oxideDimethylaniline N-oxide (see all 4)874-52-2--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    N,N-DimethylanilineDimethylaminobenzene (see all 9)121-69-7--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    OxygenOxygen (see all 5)7782-44-7--
    SulfideSulfide (see all 4)18496-25-8--
    TrimethylamineDimethylmethaneamine (see all 6)75-50-3--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    9 DrugBank Compounds for FMO3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cimetidine-- 51481-61-9enzymesubstrate19283698 11465082 7720103
    Almotriptan-- 181183-52-8enzymesubstrate12642466
    Clozapine-- 5786-21-0enzymesubstrate19515014
    Dapsone1,1'-Sulfonylbis[4-aminobenzene] (see all 8)80-08-0enzymesubstrate19515014
    Dasatinib-- 302962-49-8enzymesubstrate18556438
    Olanzapine-- 132539-06-1enzymesubstrate10511917
    TamoxifenICI-46474 (see all 3)10540-29-1enzymesubstrate19515014
    Voriconazole-- 137234-62-9enzymesubstrate19515014
    Vandetanib4-quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]- (see all 4)443913-73-3enzymesubstrate--

    Selected Novoseek inferred chemical compound relationships for FMO3 gene (see all 30)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methyl p-tolyl sulfide 90.2 6 17942081 (1), 12695352 (1), 17142560 (1), 19571433 (1)
    benzydamine 85.7 9 11012553 (4), 15564885 (2), 17142560 (1), 19571433 (1)
    sulindac sulfide 83.7 8 10807940 (1), 17559352 (1), 16214918 (1), 19321370 (1) (see all 5)
    tmao 83 16 9776311 (2), 17531949 (1), 19881207 (1), 11465082 (1) (see all 9)
    methimazole 81.7 7 12814961 (2), 11414682 (1), 9344459 (1), 17942081 (1)
    thiobenzamide 80.4 1 15363661 (1)
    s-(1,2-dichlorovinyl)-l-cysteine 73.1 2 17892265 (1), 9884308 (1)
    n-octylamine 72.7 2 9750169 (1)
    flavin 71.4 14 15623613 (1), 17302959 (1), 14709624 (1), 16214918 (1) (see all 12)
    bufuralol 66.3 1 11038163 (1)

    4 PharmGKB related drug/compound annotations for FMO3 gene    About this table
    Drug/compound PharmGKB Annotation
    afatinib
    anthracyclines and related substancesCA  
    dasatinib
    olanzapineCA  



    Find genes that share compounds with FMO3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FMO3 gene (2 alternative transcripts): 
    NM_001002294.2  NM_006894.5  

    Unigene Cluster for FMO3:

    Flavin containing monooxygenase 3
    Hs.445350  [show with all ESTs]
    Unigene Representative Sequence: AK223166
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367755(uc001ghi.3 uc001ghh.3 uc010pmb.2 uc010pmc.2)
    ENST00000530212(uc010pma.1) ENST00000534514 ENST00000472784 ENST00000479749
    ENST00000478457 ENST00000392085 ENST00000538429 ENST00000542847
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FMO3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate FMO3:
    hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidFMO3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FMO3
    Predesigned siRNA for gene silencing in human, mouse, rat FMO3
    Clone
    Products:
         
    OriGene clones in human, mouse for FMO3 (see all 11)
    OriGene ORF clones in mouse, rat for FMO3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FMO3 (NM_001002294)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FMO3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FMO3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FMO3
    OriGene qSTAR qPCR primer pairs in human, mouse for FMO3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FMO3
      QuantiTect SYBR Green Assays in human, mouse, rat FMO3
      QuantiFast Probe-based Assays in human, mouse, rat FMO3

    Additional mRNA sequence: 

    AK223166.1 AK296105.1 AK298406.1 AK298456.1 AK310785.1 AK313197.1 BC032016.1 M83772.1 
    Z47552.1 

    12 DOTS entries:

    DT.95166654  DT.413620  DT.92431685  DT.95166656  DT.92431687  DT.92431683  DT.99972987  DT.92042899 
    DT.92431692  DT.100767373  DT.92431689  DT.95166657 

    Selected AceView cDNA sequences (see all 86):

    AV648086 NM_001002294 H71848 T95250 AV688561 BC032016 BI758833 AU107182 
    BM989135 AV654417 AU100084 AI052149 BU625130 NM_006894 CA395462 AV699326 
    Z47552 AV697859 R91525 BI756793 CB164094 AW303651 BM920762 AV682767 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FMO3    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
    SP1:                                -     -                                   -                     
    SP2:                    -           -     -                                   -                     
    SP3:                    -                                                                           
    SP4:                                                                                                


    ECgene alternative splicing isoforms for FMO3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FMO3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTCCTTTTT
    FMO3 Expression
    About this image


    FMO3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    FMO3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FMO3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445350

    UniProtKB/Swiss-Prot: FMO3_HUMAN, P31513
    Tissue specificity: Liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FMO3: 
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FMO3
    OriGene qSTAR qPCR primer pairs in human, mouse for FMO3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FMO3
    QuantiTect SYBR Green Assays in human, mouse, rat FMO3
    QuantiFast Probe-based Assays in human, mouse, rat FMO3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMO3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for FMO3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fmo31 , 5 flavin containing monooxygenase 31, 5 83.11(n)1
    79.66(a)1
      1 (70.34 cM)5
    142621  NM_008030.11  NP_032056.11 
     1629538025 
    chicken
    (Gallus gallus)
    Aves FMO36
    Gallus gallus flavin containing monooxygenase 6 ps...
    61(a)
    1 → many
    8(4792393-4800086)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Dimethylaniline monooxygenase [N-oxide-forming]
    74(a)
    70(a)
    many ↔ many
    many ↔ many
    AAWZ02037914(2376-13155)
    GL343300.1(1575512-1596183)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fmo31 flavin containing monooxygenase 3 63.26(n)
    60.98(a)
      548424  NM_001015707.1  NP_001015707.1 


    ENSEMBL Gene Tree for FMO3 (if available)
    TreeFam Gene Tree for FMO3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FMO3 gene
    FMO22  FMO42  FMO52  FMO6P2  FMO12  
    6 SIMAP similar genes for FMO3 using alignment to 5 protein entries:     FMO3_HUMAN (see all proteins):
    FMO6P    DKFZp667E137    FMO2    FMO1    FMO4    FMO5

    Find genes that share paralogs with FMO3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FMO3 (see all 807)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs725493311,2,,4
    CTrimethylaminuria (TMAU)4 pathogenic1177636044(+) GTCCCA/G/TCTGGG 4 R L mis11NA 3560
    VAR_0373084
    Trimethylaminuria (TMAU)4--see VAR_0373082 M I mis40--------
    VAR_0081454
    Trimethylaminuria (TMAU)4--see VAR_0081452 R W mis40--------
    VAR_0373064
    Trimethylaminuria (TMAU)4--see VAR_0373062 E K mis40--------
    VAR_0373074
    Trimethylaminuria (TMAU)4--see VAR_0373072 N S mis40--------
    VAR_0081464
    Trimethylaminuria (TMAU)4--see VAR_0081462 A T mis40--------
    VAR_0024234
    Trimethylaminuria (TMAU)4--see VAR_0024232 M I mis40--------
    VAR_0024244
    Trimethylaminuria (TMAU)4--see VAR_0024242 P L mis40--------
    rs725493201,2
    Cpathogenic1177614455(+) GCTTTA/GAGAAG 4 K E mis10--------
    rs725493211,2
    Cpathogenic1177625511(+) GCAGGA/GCTAGC 4 T A mis10--------

    HapMap Linkage Disequilibrium report for FMO3 (171060018 - 171086959 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FMO3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv28731CNV Gain+Loss19812545

    Human Gene Mutation Database (HGMD): FMO3
    Locus Specific Mutation Databases (LSDB): FMO3

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FMO3
    DNA2.0 Custom Variant and Variant Library Synthesis for FMO3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 136132   
    OMIM disorders: 602079  
    UniProtKB/Swiss-Prot: FMO3_HUMAN, P31513
  • Trimethylaminuria (TMAU) [MIM:602079]: Inborn error of metabolism associated with an offensive body odor
    and caused by deficiency of FMO-mediated N-oxidation of amino-trimethylamine (TMA) derived from foodstuffs.
    Affected individuals excrete relatively large amounts of TMA in their urine, sweat, and breath, and exhibit a
    fishy body odor characteristic of the malodorous free amine. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 3 diseases for FMO3:    
    About MalaCards
    trimethylaminuria    lymphocytic choriomeningitis    familial adenomatous polyposis

    1 disease from the University of Copenhagen DISEASES database for FMO3:
    Lymphocytic choriomeningitis

    Find genes that share disorders with FMO3           About GenesLikeMe

    5 Novoseek inferred disease relationships for FMO3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trimethylaminuria 98.2 85 17584019 (4), 9282831 (4), 19881207 (3), 16601883 (3) (see all 31)
    metabolic disorder 40.6 6 17584019 (1), 17531949 (1), 17142560 (1)
    familial adenomatous polyposis 27.1 2 17559352 (1)
    polyposis 25.4 3 15623613 (2), 16214918 (1)
    adenoma 0 1 16214918 (1)

    GeneTests: FMO3
    GeneReviews: FMO3
    Genetic Association Database (GAD): FMO3
    Human Genome Epidemiology (HuGE) Navigator: FMO3 (23 documents)

    Export disorders for FMO3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FMO3 gene, integrated from 10 sources (see all 171):
    (articles sorted by number of sources associating them with FMO3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural organization of the human flavin-containing monooxygenase 3 gene (FMO3), the favored candidate for fish-odor syndrome, determined directly from genomic DNA. (PubMed id 9417913)1, 2, 3, 9 Dolphin C.T.... Phillips I.R. (Genomics 1997)
    2. Genetic polymorphism of the flavin-containing monooxygenase 3 (FMO3) associated with trimethylaminuria (fish odor syndrome): observations from Japanese patients. (PubMed id 17584019)1, 4, 9 Yamazaki H. and Shimizu M. (Curr. Drug Metab. 2007)
    3. Two new polymorphisms of the FMO3 gene in Caucasian and African-American populations: comparative genetic and functional studies. (PubMed id 12814961)1, 4, 9 Lattard V....Cashman J.R. (Drug Metab. Dispos. 2003)
    4. Population distribution of human flavin-containing monooxygenase form 3: gene polymorphisms. (PubMed id 11717182)1, 4, 9 Cashman J.R....Braun A. (Drug Metab. Dispos. 2001)
    5. Compound heterozygosity for missense mutations in the flavin- containing monooxygenase 3 (FM03) gene in patients with fish-odour syndrome. (PubMed id 11191884)1, 2, 9 Dolphin C.T.... Phillips I.R. (Pharmacogenetics 2000)
    6. Analysis of flavin-containing monooxygenase 3 genotype data in populations administered the anti-schizophrenia agent olanzapine. (PubMed id 19356079)1, 4, 9 Cashman J.R....Braun A. (Drug Metab Lett 2008)
    7. Two novel single nucleotide polymorphisms (SNPs) of the FMO3 gene in Japanese. (PubMed id 15618753)1, 2, 9 Fujieda M.... Kamataki T. (Drug Metab. Pharmacokinet. 2003)
    8. Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians. (PubMed id 16324215)1, 4, 9 Dolan C....Treacy E.P. (BMC Med. Genet. 2005)
    9. [The frequency distribution of flavin-containing monooxygenase 3 mutant alleles in 28 populations from Yunnan]. (PubMed id 12903042)1, 4, 9 Zeng W.M....Xiao C.J. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2003)
    10. Functional characterization of genetic variants of human FMO3 associated with trimethylaminuria. (PubMed id 17531949)1, 2, 9 Yeung C.K.... Rettie A.E. (Arch. Biochem. Biophys. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2328 HGNC: 3771 AceView: FMO3 Ensembl:ENSG00000007933 euGenes: HUgn2328
    ECgene: FMO3 Kegg: 2328 H-InvDB: FMO3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FMO3 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=FMO3[genesymbol]
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fmo3/
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/149

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FMO3 gene:
    Search GeneIP for patents involving FMO3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FMO3   OriGene RNAi products in human, mouse, rat for FMO3  
     OriGene qPCR primer pairs and template standards for FMO3   OriGene Protein Over-expression Lysate for FMO3  
     OriGene MassSpec something-or-other for FMO3   OriGene clones in human, mouse for FMO3  
     OriGene qSTAR qPCR primer pairs in human, mouse for FMO3   OriGene Purified Protein for FMO3  
     OriGene ORF clones in mouse, rat for FMO3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FMO3   OriGene Custom Protein Services for FMO3  

     
     
     Block miRNA regulation of human, mouse, rat FMO3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FMO3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FMO3 Predesigned siRNA for gene silencing in human, mouse, rat FMO3
     QuantiFast Probe-based Assays in human, mouse, rat FMO3 QuantiTect SYBR Green Assays in human, mouse, rat FMO3
     PCR Arrays including human, mouse, rat FMO3 Search Chromatin IP Primers for FMO3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FMO3  Search GeneGlobe Interaction Network for FMO3
     Regulatory tfbs in FMO3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FMO3 GenScript cDNA clones with any tag delivered in your preferred vector for FMO3
     GenScript Custom Assay Services for FMO3 GenScript Custom overexpressing Cell Line Services for FMO3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FMO3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for FMO3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FMO3 antibodies
     FMO3 proteins
     FMO3 lysates
     Antibodies for FMO3
     See all of Abcam's Antibodies, Kits and Proteins for FMO3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FMO3
     Antibodies for FMO3
     ELISAs for FMO3
     CLIAs for FMO3



     Browse ESI BIO Cell Lines and PureStem Progenitors for FMO3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMO3
     SwitchGear 3'UTR luciferase reporter plasmids for FMO3
     SwitchGear Promoter luciferase reporter plasmids for FMO3
     ThermoFisher Antibody for FMO3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FMO3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FMO3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FMO3
     LSBio Antibodies in human, mouse, rat for FMO3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for FMO3
      Search eBioscience for proteins for FMO3
      Search eBioscience for elisas for FMO3
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FMO3 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4