Aliases for FMO2 Gene
External Ids for FMO2 Gene
Previous GeneCards Identifiers for FMO2 Gene
This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
GeneCards Summary for FMO2 Gene
FMO2 (Flavin Containing Monooxygenase 2) is a Protein Coding gene. Diseases associated with FMO2 include Trimethylaminuria and Kabuki Syndrome 1. Among its related pathways are cytochrome P450 and Busulfan Pathway, Pharmacodynamics. GO annotations related to this gene include oxidoreductase activity and monooxygenase activity. An important paralog of this gene is FMO3.
UniProtKB/Swiss-Prot for FMO2 Gene
Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of methimazole. The truncated form is catalytically inactive.