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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FMO2 Gene

protein-coding GIFtS: 62
GCID: GC01P171154

flavin containing monooxygenase 2 (non-functional)

(Previous name: flavin containing monooxygenase 2 )

Explore 4 diseases affiliated with
FMO2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Flavin Containing Monooxygenase 2 (Non-Functional)¹ ²		EC 1.14.13.8³ ⁸
Dimethylaniline Oxidase 2² ³		Flavin Containing Monooxygenase 2¹
Pulmonary Flavin-Containing Monooxygenase 2² ³		FMO1B1²
FMO 1B1² ³		Dimethylaniline Monooxygenase [N-Oxide-Forming] 2²
FMO 2² ³		FMO, Pulmonary²

External Ids:	HGNC: 3770¹	Entrez Gene: 2327²	Ensembl: ENSG00000094963⁷	OMIM: 603955⁵	UniProtKB: Q99518³

Export aliases for FMO2 gene to outside databases

Previous GC identifers: GC01P168718 GC01P166783 GC01P167735 GC01P168393 GC01P167886 GC01P169420 GC01P142377

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FMO2:

The flavin-containing monooxygenases are NADPH-dependent enzymes that catalyze the oxidation of many drugs and

xenobiotics. In most mammals, there is a flavin-containing monooxygenase that catalyzes the N-oxidation of some

primary alkylamines through an N-hydroxylamine intermediate. However, in humans, this enzyme is truncated and is

probably rapidly degraded. The protein encoded by this gene represents the truncated form and apparently has no

catalytic activity. A functional allele found in African Americans has been reported, but no sequence evidence has

been deposited to support the finding. This gene is found in a cluster with the FMO1, FMO3, and FMO4 genes on

chromosome 1. (provided by RefSeq, Jul 2009)

UniProtKB/Swiss-Prot: FMO2_HUMAN, Q99518

Function: Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate.

Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of

methimazole. The truncated form is catalytically inactive

Gene Wiki entry for FMO2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FMO2 gene promoter:
C/EBPbeta p53 Pax-6 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 E2F-1 E2F FOXJ2 (long isoform) FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FMO2 promoter sequence

Search SABiosciences Chromatin IP Primers for FMO2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FMO2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.3 Ensembl cytogenetic band: 1q24.3 HGNC cytogenetic band: 1q24.3

FMO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FMO2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P171154: view genomic region (about GC identifiers)

Start:	171,154,347 bp from pter	End:	171,181,822 bp from pter
Size:	27,476 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FMO2_HUMAN, Q99518 (See protein sequence)

Recommended Name: Dimethylaniline monooxygenase [N-oxide-forming] 2

Size: 471 amino acids; 53644 Da

Cofactor: FAD

Cofactor: Magnesium

Subcellular location: Microsome membrane. Endoplasmic reticulum membrane

Secondary accessions: Q5EBX4 Q86U73 Q9BRX1

Explore the universe of human proteins at neXtProt for FMO2: NX_Q99518

Post-translational modifications:

The truncated form is probably unable to fold correctly and is rapidly degraded¹

FMO2*1 is sumoylated at 'Lys-492'¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q99518

4/34 DME Specific Peptides for FMO2 (Q99518) (see all 34)

DIIKRNE

FDLLKYI

FATGYSF

QSQTLQT

FMO2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001451.1

ENSEMBL proteins:

ENSP00000209929 ENSP00000405905

Reactome Protein details: Q99518
Human Recombinant Protein Products:

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	Uscn Proteins for FMO2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005792	microsome	--	--
GO:0016020	membrane	IDA	9804831
GO:0016021	integral to membrane	IEA	--

FMO2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FMO2 for domains About GeneDecksing

3 InterPro domains/families:

IPR002254 Flavin_mOase_2

IPR020946 Flavin_mOase-like

IPR000960 Flavin_mOase

Graphical View of Domain Structure for InterPro Entry Q99518

ProtoNet protein and cluster: Q99518

3 Blocks protein families:

IPB000960 Flavin-containing monooxygenase (FMO) signature

IPB001327 Pyridine nucleotide-disulphide oxidoreductase

IPB002254 Flavin-containing monooxygenase (FMO) 2 signature

UniProtKB/Swiss-Prot: FMO2_HUMAN, Q99518

Similarity: Belongs to the FMO family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FMO2_HUMAN, Q99518

Function: Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate.

Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of

methimazole. The truncated form is catalytically inactive

Catalytic activity: N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O

Genatlas biochemistry entry for FMO2:

flavin containing monooxygenase 2,microsomal,pulmonary,protein catalyzing the N-oxidation of primary alkylamines

Enzyme Number (IUBMB): EC 1.14.13.8¹ ²

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		hsa-miR-1290 hsa-miR-452* hsa-miR-4282 hsa-miR-1911* hsa-miR-1262 hsa-miR-3667-3p hsa-miR-146a* hsa-miR-4314

		SwitchGear 3'UTR luciferase reporter plasmid: FMO2 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMO2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004497	monooxygenase activity	TAS	--
GO:0004499	N,N-dimethylaniline monooxygenase activity	IDA	11744609
GO:0050660	flavin adenine dinucleotide binding	IEA	--
GO:0050661	NADP binding	IEA	--

FMO2 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Catalytic cycle of mammalian FMOs

Catalytic cycle of mammalian FMOs

1.00

FMO oxidizes nucleophiles

0.60

Biological oxidations

Biological oxidations

1.00

metapathway biotransformation

0.41

Metabolism

Metabolism

1.00

Busulfan Pathway, Pharmacodynamics

Busulfan Pathway, Pharmacodynamics

1.00

Drug metabolism - cytochrome P450

Drug metabolism - cytochrome P450

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 BioSystems Pathways for FMO2

	Catalytic cycle of mammalian FMOs
	nicotine degradation IV
	metapathway biotransformation

4 Reactome Pathways for FMO2

	Metabolism
	Biological oxidations
	Phase 1 - Functionalization of compounds
	FMO oxidizes nucleophiles

1 PharmGKB Pathway for FMO2

Busulfan Pathway, Pharmacodynamics

1 Kegg Pathway (Kegg details for FMO2):

Drug metabolism - cytochrome P450

FMO2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FMO2

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for FMO2 (ENSP00000209929⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CYP2D6	ENSP00000353820⁴	STRING: ENSP00000353820
CYP3A4	ENSP00000337915⁴	STRING: ENSP00000337915
CYP3A43	ENSP00000222382⁴	STRING: ENSP00000222382
CYP3A5	ENSP00000222982⁴	STRING: ENSP00000222982
CYP3A7	ENSP00000337450⁴	STRING: ENSP00000337450

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006082	organic acid metabolic process	IDA	11744609
GO:0006739	NADP metabolic process	IDA	11744609
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0009404	toxin metabolic process	IDA	11744609
GO:0017144	drug metabolic process	IDA	11744609

FMO2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FMO2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FMO2

9 HMDB Compounds for FMO2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Dimethylaniline-N-oxide	Dimethylaniline N-oxide (see all 4)	874-52-2	--
FAD	1H-Purin-6-amine flavin dinucleotide (see all 21)	146-14-5	--
Imipramine	Antideprin (see all 27)	50-49-7	--
Magnesium	Magnesium (see all 2)	7439-95-4	--
N,N-Dimethylaniline	Dimethylaminobenzene (see all 9)	121-69-7	--
NADP	Adenine-nicotinamide dinucleotide phosphate (see all 18)	53-59-8	--
NADPH	2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)	53-57-6	--
Oxygen	Oxygen (see all 5)	7782-44-7	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

2 Novoseek chemical compound relationships for FMO2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
methimazole	78.5	1	17942081 (1)
thimet	77.6	1	15294458 (1)

Search CenterWatch for drugs/clinical trials and news about FMO2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FMO2 gene:

NM_001460.2

Unigene Cluster for FMO2:

Flavin containing monooxygenase 2 (non-functional)

Hs.144912 [show with all ESTs]

Unigene Representative Sequence: NM_001460

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000209929(uc010pmd.1) ENST00000462643 ENST00000489354 ENST00000529935

ENST00000493513 ENST00000483192 ENST00000488431 ENST00000441535(uc001ghk.1)

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		hsa-miR-1290 hsa-miR-452* hsa-miR-4282 hsa-miR-1911* hsa-miR-1262 hsa-miR-3667-3p hsa-miR-146a* hsa-miR-4314

		SwitchGear 3'UTR luciferase reporter plasmid: FMO2 3' UTR sequence

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Additional cDNA sequence:

AK098145.1 AK304385.1 AK312877.1 AL833218.1 BC005894.1 BT006979.1 Y09267.1

7 DOTS entries:

DT.120587 DT.121453402 DT.100010038 DT.100010037 DT.100665132 DT.121453424 DT.91708801

24/101 AceView cDNA sequences (see all 101):

AK098145 BF432999 AW301644 AI820530 BQ016071 BQ002500 CA447599 BE464168

NM_001460 Y09267 BQ004808 CB321742 BM978911 CD678723 AI375922 BX501690

BQ045419 AA485450 CA390431 CA444972 BM979138 BU683843 CD677670 BC005894

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for FMO2 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7	^	8	^	9
SP1:					-				-
SP2:					-				-
SP3:					-		-		-				-		-		-
SP4:									-
SP5:					-

ECgene alternative splicing isoforms for FMO2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FMO2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAAGATTAA

About this image

FMO2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Adult Endothelial Cells

Blood Brain Barrier, Endothelium

Kidney

Proximal Tubule

Proximal Tubule Cells

Kidney

Kidney

Kidney

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FMO2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FMO2

SOURCE GeneReport for Unigene cluster: Hs.144912

UniProtKB/Swiss-Prot: FMO2_HUMAN, Q99518

Tissue specificity: Expressed in lung (at protein level). Expressed predominantly in lung, and at a much lesser extent

in kidney. Also expressed in fetal lung, but not in liver, kidney and brain

SABiosciences Expression via Pathway-Focused PCR Arrays including FMO2:

Nephrotoxicity in human mouse rat

Oxidative Stress in human mouse rat

Drug Metabolism: Phase I Enzymes in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FMO2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMO2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for FMO2 gene from 7/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	FMO2⁶	--	56(a)	1 ↔ 1	GL343300.1(1612228-1630249)
African clawed frog (Xenopus laevis)	Amphibia	BC060427.1²	--	71.71(n)		BC060427.1
zebrafish (Danio rerio)	Actinopterygii	fmo5⁶ si:dkey-239i20.2⁶ (see all 5)	si:dkey-239i20.2 (see all 5)	46(a) 44(a) (see all 5)	many ↔ many many ↔ many (see all 5)	20(15099468-15110570) 20(15090312-15096721)
fruit fly (Drosophila melanogaster)	Insecta	Fmo-2⁶ Fmo-1⁶	Flavin-containing monooxygenase 1	27(a) 27(a)	possible ortholog possible ortholog	2R(2529923-2532600) 2R(19850498-19852164)
worm (Caenorhabditis elegans)	Secernentea	fmo-11³	flavin-containing monoxygenase	42(a) (best of 6)		IV(10662222-10664313) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G12200⁶ FMO GS-OX1⁶ (see all 18)	flavin-containing monooxygenase FMO GS-OX1 (see all 18)	27(a) 27(a) (see all 18)	possible ortholog possible ortholog (see all 18)	1(4137533-4140028) 1(24499066-24502745)
rice (Oryza sativa)	Liliopsida	-- -- (see all 19)	flavin-containing monooxygenase family protein, pu... flavin-containing monooxygenase family protein, pu... (see all 19)	25(a) 25(a) (see all 19)	possible ortholog possible ortholog (see all 19)	10(21652892-21655657) 7(676501-677907)

ENSEMBL Gene Tree for FMO2 (if available)
TreeFam Gene Tree for FMO2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FMO2 gene

FMO4² FMO3² FMO5² FMO6P² FMO1²

6 SIMAP similar genes for FMO2 using alignment to 1 protein entry: FMO2_HUMAN:

DKFZp667E137 FMO5 FMO6P FMO4 FMO1 FMO3

FMO2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: FMO2_HUMAN, Q99518

Polymorphism: The sequence shown is that of the allele FMO2*2A. There are two alleles; one major, FMO2*2A (truncated

form) and one minor, FMO2*1 (full-length form similar to the protein found in other mammals). A nonsense mutation

transforms the Gln-472 of FMO2*1 in a premature stop codon. FMO2*2A occurs in essentially 100% of Caucasians and

Asians. FMO2*1 is present at a frequency of approximately 4% to 13% in the sample of population of African descent.

FMO2*2A is catalytically inactive

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs41272517^1,2	C	--	142403401(+)	`TCTGTG/AGTTAA`	1	--	ut3¹		2		WA NA	4
rs6673781^1,2	C,A,	--	142403483(+)	`TCTGTG/AGTTAA`	1	--	ut3¹ ese³		3		WA CSA	5
rs140081179^1,2		--	171152446(+)	`CACATA/CAGTTA`	1	--	us2k¹		0	--	--	--	--
rs74547254^1,2	C,F,	--	171152551(+)	`CTGTAT/GGTTGG`	1	--	us2k¹		4		NA CSA WA	242
rs149625470^1,2		--	171152674(+)	`CAACTA/GCCAAT`	1	--	us2k¹		0	--	--	--	--
rs74808462^1,2	C,,	--	171152699(+)	`TTTTTC/TTTTTT`	1	--	us2k¹		1		WA	2
rs3754493^1,2	C,F,	--	171152759(+)	`GACACG/AGTCTC`	1	--	us2k¹		8		NA WA EA	368
rs182180738^1,2		--	171152818(+)	`AGTCTC/TGACCT`	1	--	us2k¹		0	--	--	--	--
rs187154466^1,2		--	171152984(+)	`GCCTCC/TCAAAC`	1	--	us2k¹		0	--	--	--	--
rs191601943^1,2		--	171153001(+)	`GATTAC/TAGGCA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FMO2 (171154347 - 171181822 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for FMO2
2 CNVs: 70415 70417
1 Indel: 44468
Human Gene Mutation Database (HGMD): FMO2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FMO2 for disorders           About GeneDecksing

OMIM gene information: 603955    OMIM disorders: --

4 diseases for FMO2:    About MalaCards

prader-willi syndrome trimethylaminuria hearing loss hepatitis

Genetic Association Database (GAD): FMO2
Human Genome Epidemiology (HuGE) Navigator: FMO2 (8 documents)

Export disorders for FMO2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FMO2 gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with FMO2)

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world of online information

Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-Americans. (PubMed id 11042094)^{1, 2, 4, 9} Whetstine J.R....Hines R.N. (2000)
The flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional protein. (PubMed id 9804831)^{1, 2, 3, 9} Dolphin C.T.... Phillips I.R. (1998)
Haplotype and functional analysis of four flavin-containing monooxygenase isoform 2 (FMO2) polymorphisms in Hispanics. (PubMed id 15864117)^{1, 4, 9} Krueger S.K....Williams D.E. (2005)
The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa. (PubMed id 18794725)^{1, 2, 9} Veeramah K.R....Phillips I.R. (2008)
Differences in FMO2*1 allelic frequency between Hispanics of Puerto Rican and Mexican descent. (PubMed id 15355885)^{1, 4, 9} Krueger S.K....Williams D.E. (2004)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. (PubMed id 12527699)^{1, 2} Furnes B.... Schlenk D. (2003)
Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family. (PubMed id 1417778)^{1, 3} Dolphin C.T.... Phillips I.R. (1992)
Characterization of sulfoxygenation and structural im plications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413K. (PubMed id 19420133)^{1, 9} Krueger S.K....Williams D.E. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2327	HGNC: 3770	AceView: FMO2	Ensembl:ENSG00000094963	euGenes: HUgn2327
ECgene: FMO2	Kegg: 2327	H-InvDB: FMO2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FMO2	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/fmo2/

Intellectual Property for FMO2 gene
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Patent Information for FMO2 gene:
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flavin containing monooxygenase 2 (non-functional)

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flavin containing monooxygenase 2 (non-functional)

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