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FMO1 Gene

protein-coding   GIFtS: 65
GCID: GC01P171217

Flavin Containing Monooxygenase 1

  See FMO1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Flavin Containing Monooxygenase 11 2     EC 1.14.13.83 8
Dimethylaniline Oxidase 12 3     Dimethylaniline Monooxygenase [N-Oxide-Forming] 12
Fetal Hepatic Flavin-Containing Monooxygenase 12 3     Flavin-Containing Monooxygenase 1 (Fetal Liver)2
FMO 12 3     

External Ids:    HGNC: 37691   Entrez Gene: 23262   Ensembl: ENSG000000109327   OMIM: 1361305   UniProtKB: Q017403   

Export aliases for FMO1 gene to outside databases

Previous GC identifers: GC01P168781 GC01P166846 GC01P167798 GC01P168457 GC01P167949 GC01P169484 GC01P142440


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FMO1 Gene:
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing
monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with
reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme,
FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25
region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft
nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Sep 2013)

GeneCards Summary for FMO1 Gene:
FMO1 (flavin containing monooxygenase 1) is a protein-coding gene. Diseases associated with FMO1 include trimethylaminuria. GO annotations related to this gene include monooxygenase activity and flavin adenine dinucleotide binding. An important paralog of this gene is FMO2.

UniProtKB/Swiss-Prot: FMO1_HUMAN, Q01740
Function: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and
pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines

Gene Wiki entry for FMO1 (Flavin containing monooxygenase 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FMO1 gene promoter:
         HFH-3   AP-1   AML1a   AP-4   Nkx5-1   Arnt   Evi-1   C/EBPalpha   HEN1   FOXI1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFMO1 promoter sequence
   Search Chromatin IP Primers for FMO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FMO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.3   Ensembl cytogenetic band:  1q24.3   HGNC cytogenetic band: 1q24.3

FMO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FMO1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P171217:  view genomic region     (about GC identifiers)

Start:
171,217,638 bp from pter      End:
171,255,117 bp from pter
Size:
37,480 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FMO1_HUMAN, Q01740 (See protein sequence)
Recommended Name: Dimethylaniline monooxygenase [N-oxide-forming] 1  
Size: 532 amino acids; 60311 Da
Cofactor: FAD
Secondary accessions: A8K248 Q5QPT2 Q9UJC2

Explore the universe of human proteins at neXtProt for FMO1: NX_Q01740

Explore proteomics data for FMO1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FMO1 (Q01740) (see all 14)
     CFERSDD  WEGARNAI  SLYKYIFP  FDAVMVCTG 


    See FMO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001269621.1  NP_001269622.1  NP_001269623.1  NP_002012.1  

    ENSEMBL proteins: 
     ENSP00000406982   ENSP00000356724   ENSP00000346901   ENSP00000385543  
    Reactome Protein details: Q01740

    FMO1 Human Recombinant Protein Products:

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    Novus Biologicals FMO1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FMO1

     
    Search eBioscience for Proteins for FMO1 

    FMO1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    FMO1 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FMO1
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    Search eBioscience for ELISAs for FMO1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR020946 Flavin_mOase-like
     IPR012143 DiMe-aniline_mOase
     IPR002253 Flavin_mOase_1
     IPR000960 Flavin_mOase
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q01740

    ProtoNet protein and cluster: Q01740

    5 Blocks protein domains:
    IPB000759 Adrenodoxin reductase family signature
    IPB000960 Flavin-containing monooxygenase (FMO) signature
    IPB001327 Pyridine nucleotide-disulphide oxidoreductase
    IPB002253 Flavin-containing monooxygenase (FMO) 1 signature
    IPB002345 Lipocalin signature


    UniProtKB/Swiss-Prot: FMO1_HUMAN, Q01740
    Similarity: Belongs to the FMO family


    Find genes that share domains with FMO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FMO1_HUMAN, Q01740
    Function: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and
    pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines
    Catalytic activity: N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O

         Genatlas biochemistry entry for FMO1:
    flavin containing monooxygenase 1,microsomal,expressed in fetal liver

         Enzyme Number (IUBMB): EC 1.14.13.81 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity IDA19262426
    GO:0004499N,N-dimethylaniline monooxygenase activity TAS--
    GO:0016491oxidoreductase activity ----
    GO:0050660flavin adenine dinucleotide binding IEA--
    GO:0050661NADP binding IEA--
         
    Find genes that share ontologies with FMO1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FMO1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FMO1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FMO1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FMO1

    miRNA
    Products:
        
    miRTarBase miRNAs that target FMO1:
    hsa-mir-320a (MIRT044436)

    Block miRNA regulation of human, mouse, rat FMO1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate FMO1:
    hsa-miR-30c-2* hsa-miR-3664-5p hsa-miR-30c-1* hsa-miR-759 hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidFMO1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FMO1
    Predesigned siRNA for gene silencing in human, mouse, rat FMO1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FMO1

    Clone
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    OriGene ORF clones in mouse, rat for FMO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FMO1 (NM_002021)
    Sino Biological Human cDNA Clone for FMO1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FMO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FMO1

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMO1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FMO1_HUMAN, Q01740: Microsome membrane. Endoplasmic reticulum membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    peroxisome3
    cytosol2
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0043231intracellular membrane-bounded organelle ----

    Find genes that share ontologies with FMO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FMO1 About    
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    Biological oxidations0.56
    Tamoxifen metabolism0.00
    metapathway biotransformation0.42
    Tamoxifen Pathway, Pharmacokinetics0.00
    2Busulfan Pathway, Pharmacodynamics
    Busulfan Pathway, Pharmacodynamics
    FMO oxidizes nucleophiles0.00
    Catalytic cycle of mammalian FMOs0.00
    3Cytochrome P450 - arranged by substrate type
    Phase 1 - Functionalization of compounds0.75
    4Chemical carcinogenesis
    Drug metabolism - cytochrome P4500.69
    5Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with FMO1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for FMO1
        Catalytic cycle of mammalian FMOs
    Tamoxifen metabolism
    metapathway biotransformation


    1 Reactome Pathway for FMO1
        FMO oxidizes nucleophiles

    2 PharmGKB Pathways for FMO1
        Busulfan Pathway, Pharmacodynamics
    Tamoxifen Pathway, Pharmacokinetics

    1 Kegg Pathway  (Kegg details for FMO1):
        Drug metabolism - cytochrome P450

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FMO1: 
              Hepatotoxicity in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FMO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for FMO1 (ENSP000003469014) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYP2D6ENSP000003538204STRING: ENSP00000353820
    CYP3A4ENSP000003379154STRING: ENSP00000337915
    CYP3A43ENSP000002223824STRING: ENSP00000222382
    CYP3A5ENSP000002229824STRING: ENSP00000222982
    CYP3A7ENSP000003374504STRING: ENSP00000337450
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006082organic acid metabolic process IDA15144220
    GO:0006805xenobiotic metabolic process TAS--
    GO:0006970response to osmotic stress IEA--
    GO:0009404toxin metabolic process IDA15144220
    GO:0032496response to lipopolysaccharide IEA--

    Find genes that share ontologies with FMO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FMO1

    7 HMDB Compounds for FMO1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dimethylaniline-N-oxideDimethylaniline N-oxide (see all 4)874-52-2--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    N,N-DimethylanilineDimethylaminobenzene (see all 9)121-69-7--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    6 DrugBank Compounds for FMO1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    CevimelineCevimeline hydrochloride (see all 3)107233-08-9enzymesubstrate11725960 12608011
    Cimetidine-- 51481-61-9enzymesubstrate19283698 11465082
    LorcaserinAPD-356 (see all 2)846589-98-8enzymesubstrate22266842
    TamoxifenICI-46474 (see all 3)10540-29-1enzymesubstrate19515014
    Voriconazole-- 137234-62-9enzymesubstrate19515014
    Vandetanib4-quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]- (see all 4)443913-73-3enzymesubstrate--

    Selected Novoseek inferred chemical compound relationships for FMO1 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methyl p-tolyl sulfide 91.7 5 14976351 (2), 10950857 (1), 17942081 (1)
    thiobenzamide 80.3 1 9076656 (1)
    methimazole 80.2 4 10901713 (1), 9580872 (1), 17942081 (1), 14976351 (1)
    n-octylamine 72.5 1 9580872 (1)
    imipramine 66.6 4 12527797 (1), 19262426 (1), 9076656 (1)
    sulfoxide 66.6 6 12490590 (1), 12642475 (1), 14976351 (1)
    nn-dimethylaniline 66.5 1 9076656 (1)
    fenthion 64.6 5 17253727 (2), 14976351 (2)
    indole-3-carbinol 58.2 6 8886600 (2), 11489435 (2)
    chlorpromazine 53 2 16985102 (1), 9076656 (1)

    1 PharmGKB related drug/compound annotation for FMO1 gene    About this table
    Drug/compound PharmGKB Annotation
    olanzapineCA  



    Find genes that share compounds with FMO1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FMO1 gene (4 alternative transcripts): 
    NM_001282692.1  NM_001282693.1  NM_001282694.1  NM_002021.2  

    Unigene Cluster for FMO1:

    Flavin containing monooxygenase 1
    Hs.1424  [show with all ESTs]
    Unigene Representative Sequence: AK097039
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000433267 ENST00000367750(uc009wvz.3 uc010pme.2 uc001ghl.3)
    ENST00000469112 ENST00000354841(uc001ghm.3) ENST00000459868 ENST00000472893
    ENST00000469711 ENST00000402921
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate FMO1:
    hsa-miR-30c-2* hsa-miR-3664-5p hsa-miR-30c-1* hsa-miR-759 hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidFMO1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FMO1
    Clone
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    OriGene ORF clones in mouse, rat for FMO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FMO1 (NM_002021)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FMO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FMO1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FMO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FMO1
      QuantiTect SYBR Green Assays in human, mouse, rat FMO1
      QuantiFast Probe-based Assays in human, mouse, rat FMO1

    Additional mRNA sequence: 

    AK097039.1 AK290113.1 AK296198.1 AK315100.1 BC047129.1 M64082.1 

    9 DOTS entries:

    DT.452339  DT.121400992  DT.40106093  DT.95335256  DT.100755252  DT.100717139  DT.75181202  DT.95160913 
    DT.92026409 

    Selected AceView cDNA sequences (see all 102):

    AI743988 BC047129 AI460325 BX105070 R94540 AI373298 CR619998 AL544898 
    AK097039 AA863111 M64082 AI373066 AI734238 BI765199 NM_002021 AI138264 
    AI566029 T28483 AI261683 BQ011599 AA935153 AA923069 BG402243 BX390294 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FMO1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
    SP1:              -     -     -     -                 -                                                                           
    SP2:                                                  -                                                                           
    SP3:                                                                                                  -                           
    SP4:                    -     -     -                 -                                                                           
    SP5:                    -     -     -                                                                                             


    ECgene alternative splicing isoforms for FMO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    FMO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCCAGTGGG
    FMO1 Expression
    About this image


    FMO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Primitive Heart Tube Cells Primitive Heart Tube
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
    FMO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FMO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1424

    UniProtKB/Swiss-Prot: FMO1_HUMAN, Q01740
    Tissue specificity: Expressed mainly in fetal liver, adult kidney and, to a lesser extent, the intestine

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FMO1: 
              Hepatotoxicity in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FMO1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fmo11 , 5 flavin containing monooxygenase 11, 5 84.71(n)1
    83.27(a)1
      1 (70.34 cM)5
    142611  NM_010231.21  NP_034361.11 
     1628295615 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    62(a)
    many ↔ many
    GL343300.1(1636634-1660289)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fmo21 flavin containing monooxygenase 2 (non-functional) 59.23(n)
    50.66(a)
      594983  NM_001030424.1  NP_001025595.1 


    ENSEMBL Gene Tree for FMO1 (if available)
    TreeFam Gene Tree for FMO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FMO1 gene
    FMO22  FMO42  FMO32  FMO52  FMO6P2  
    6 SIMAP similar genes for FMO1 using alignment to 4 protein entries:     FMO1_HUMAN (see all proteins):
    DKFZp667E137    FMO2    FMO6P    FMO5    FMO3    FMO4

    Find genes that share paralogs with FMO1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FMO1 (see all 932)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1447559061,2
    C--171215656(+) TGGTC-/CAACAATGA
    CAGCATCATCAT
    CATCA
    1 -- int10--------
    rs670509431,2
    C--171215658(+) GTCCA-/ACAATGACA
    GCATCATCATCA
    TCATC
    1 -- int10--------
    rs1870148431,2
    --171215971(+) CCCCCA/CACTCC 1 -- int10--------
    rs1929841841,2
    --171216199(+) TACCAC/TGAATT 1 -- int10--------
    rs1836008541,2
    --171216226(+) ATTGAC/TGGGCA 1 -- int10--------
    rs1888925141,2
    --171216439(+) GTTCAC/GCTGGA 1 -- int10--------
    rs1932759561,2
    --171216494(+) CTCCTA/CAAGGA 1 -- int10--------
    rs1847506471,2
    --171216507(+) CCTGTC/GAGATA 1 -- int10--------
    rs1148656901,2
    F--171216672(+) GTTTGC/TGTGTT 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1395969141,2
    --171216703(+) CACTCA/GCACTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for FMO1 (171217638 - 171255117 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FMO1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831882CNV Loss17160897
    esv28731CNV Gain+Loss19812545

    Human Gene Mutation Database (HGMD): FMO1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FMO1
    DNA2.0 Custom Variant and Variant Library Synthesis for FMO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 136130    OMIM disorders: --

    1 disease for FMO1:    
    About MalaCards
    trimethylaminuria


    Find genes that share disorders with FMO1           About GenesLikeMe

    1 Novoseek inferred disease relationship for FMO1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trimethylaminuria 75.8 1 12678693 (1)

    Genetic Association Database (GAD): FMO1
    Human Genome Epidemiology (HuGE) Navigator: FMO1 (7 documents)

    Export disorders for FMO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FMO1 gene, integrated from 10 sources (see all 84):
    (articles sorted by number of sources associating them with FMO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, primary sequence, and chromosomal mapping of a human flavin- containing monooxygenase (FMO1). (PubMed id 1712018)1, 2, 9 Dolphin C.T.... Phillips I.R. (J. Biol. Chem. 1991)
    2. Increased incidence of FMO1 gene single nucleotide polymorphisms in sporadic amyotrophic lateral sclerosis. (PubMed id 17127561)1, 4, 9 Cereda C....Ceroni M. (Amyotroph Lateral Scler 2006)
    3. Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. (PubMed id 12527699)1, 2, 9 Furnes B.... Schlenk D. (Drug Metab. Dispos. 2003)
    4. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PubMed id 21658281)1, 4 Aouizerat B.E....Tseng Z.H. (BMC Cardiovasc Disord 2011)
    5. Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes. (PubMed id 20056567)1, 4 Searles Nielsen S....Mueller B.A. (Environ. Health Perspect. 2010)
    6. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    7. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1, 4 Ross C.J....Hayden M.R. (Nat. Genet. 2009)
    8. Determination of genetic predisposition to patent ductus arteriosus in preterm infants. (PubMed id 19336370)1, 4 Dagle J.M....Murray J.C. (Pediatrics 2009)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2326 HGNC: 3769 AceView: FMO1 Ensembl:ENSG00000010932 euGenes: HUgn2326
    ECgene: FMO1 Kegg: 2326 H-InvDB: FMO1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FMO1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FMO1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fmo1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FMO1 gene:
    Search GeneIP for patents involving FMO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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