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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FMO1 Gene

protein-coding GIFtS: 63
GCID: GC01P171217

flavin containing monooxygenase 1

Explore 6 diseases affiliated with
FMO1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Flavin Containing Monooxygenase 1¹ ²		EC 1.14.13.8³ ⁸
Dimethylaniline Oxidase 1² ³		Dimethylaniline Monooxygenase [N-Oxide-Forming] 1²
Fetal Hepatic Flavin-Containing Monooxygenase 1² ³		Flavin-Containing Monooxygenase 1 (Fetal Liver)²
FMO 1² ³

External Ids:	HGNC: 3769¹	Entrez Gene: 2326²	Ensembl: ENSG00000010932⁷	OMIM: 136130⁵	UniProtKB: Q01740³

Export aliases for FMO1 gene to outside databases

Previous GC identifers: GC01P168781 GC01P166846 GC01P167798 GC01P168457 GC01P167949 GC01P169484 GC01P142440

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FMO1:

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and

is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation

capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2

found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases

are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs,

pesticides, and xenobiotics. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FMO1_HUMAN, Q01740

Function: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and

pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines

Gene Wiki entry for FMO1 (Flavin containing monooxygenase 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FMO1 gene promoter:
HFH-3 AP-1 AML1a AP-4 Nkx5-1 Arnt Evi-1 C/EBPalpha HEN1 FOXI1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FMO1 promoter sequence

Search SABiosciences Chromatin IP Primers for FMO1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FMO1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.3 Ensembl cytogenetic band: 1q24.3 HGNC cytogenetic band: 1q24.3

FMO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FMO1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P171217: view genomic region (about GC identifiers)

Start:	171,217,638 bp from pter	End:	171,255,117 bp from pter
Size:	37,480 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FMO1_HUMAN, Q01740 (See protein sequence)

Recommended Name: Dimethylaniline monooxygenase [N-oxide-forming] 1

Size: 532 amino acids; 60311 Da

Cofactor: FAD

Subcellular location: Microsome membrane. Endoplasmic reticulum membrane

Secondary accessions: A8K248 Q5QPT2 Q9UJC2

Explore the universe of human proteins at neXtProt for FMO1: NX_Q01740

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q01740

4/14 DME Specific Peptides for FMO1 (Q01740) (see all 14)

CFERSDD

WEGARNAI

SLYKYIFP

FDAVMVCTG

FMO1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002012.1

ENSEMBL proteins:

ENSP00000356724 ENSP00000406982 ENSP00000346901 ENSP00000385543

Reactome Protein details: Q01740
Human Recombinant Protein Products for FMO1:

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	Uscn Proteins for FMO1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005788	endoplasmic reticulum lumen	TAS	--
GO:0005792	microsome	--	--
GO:0016021	integral to membrane	IEA	--
GO:0031227	intrinsic to endoplasmic reticulum membrane	IEA	--

FMO1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for FMO1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FMO1 for domains About GeneDecksing

5 InterPro domains/families:

IPR020946 Flavin_mOase-like

IPR012143 DiMe-aniline_mOase

IPR002253 Flavin_mOase_1

IPR000960 Flavin_mOase

IPR016040 NAD(P)-bd_dom

Graphical View of Domain Structure for InterPro Entry Q01740

ProtoNet protein and cluster: Q01740

5 Blocks protein families:

IPB000759 Adrenodoxin reductase family signature

IPB000960 Flavin-containing monooxygenase (FMO) signature

IPB001327 Pyridine nucleotide-disulphide oxidoreductase

IPB002253 Flavin-containing monooxygenase (FMO) 1 signature

IPB002345 Lipocalin signature

UniProtKB/Swiss-Prot: FMO1_HUMAN, Q01740

Similarity: Belongs to the FMO family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: FMO1_HUMAN, Q01740

Function: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and

pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines

Catalytic activity: N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O

Genatlas biochemistry entry for FMO1:

flavin containing monooxygenase 1,microsomal,expressed in fetal liver

Enzyme Number (IUBMB): EC 1.14.13.8¹ ²

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004497	monooxygenase activity	TAS	1712018
GO:0004499	N,N-dimethylaniline monooxygenase activity	TAS	--
GO:0050660	flavin adenine dinucleotide binding	IEA	--
GO:0050661	NADP binding	IEA	--

FMO1 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FMO1

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMO1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Catalytic cycle of mammalian FMOs

Catalytic cycle of mammalian FMOs

1.00

FMO oxidizes nucleophiles

0.60

Tamoxifen metabolism

Tamoxifen metabolism

1.00

Tamoxifen Pathway, Pharmacokinetics

0.68

Biological oxidations

Biological oxidations

1.00

metapathway biotransformation

0.41

Metabolism

Metabolism

1.00

Busulfan Pathway, Pharmacodynamics

Busulfan Pathway, Pharmacodynamics

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 BioSystems Pathways for FMO1

	Catalytic cycle of mammalian FMOs
	Tamoxifen metabolism
	metapathway biotransformation

4 Reactome Pathways for FMO1

	Metabolism
	Biological oxidations
	Phase 1 - Functionalization of compounds
	FMO oxidizes nucleophiles

2 PharmGKB Pathways for FMO1

	Busulfan Pathway, Pharmacodynamics
	Tamoxifen Pathway, Pharmacokinetics

1 Kegg Pathway (Kegg details for FMO1):

Drug metabolism - cytochrome P450

FMO1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FMO1

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/13 Interacting proteins for FMO1 (ENSP00000346901⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CYP2D6	ENSP00000353820⁴	STRING: ENSP00000353820
CYP3A4	ENSP00000337915⁴	STRING: ENSP00000337915
CYP3A43	ENSP00000222382⁴	STRING: ENSP00000222382
CYP3A5	ENSP00000222982⁴	STRING: ENSP00000222982
CYP3A7	ENSP00000337450⁴	STRING: ENSP00000337450

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006082	organic acid metabolic process	IDA	15144220
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0006970	response to osmotic stress	IEA	--
GO:0009404	toxin metabolic process	IDA	15144220
GO:0032496	response to lipopolysaccharide	IEA	--

FMO1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FMO1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FMO1

7 HMDB Compounds for FMO1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Dimethylaniline-N-oxide	Dimethylaniline N-oxide (see all 4)	874-52-2	--
FAD	1H-Purin-6-amine flavin dinucleotide (see all 21)	146-14-5	--
N,N-Dimethylaniline	Dimethylaminobenzene (see all 9)	121-69-7	--
NADP	Adenine-nicotinamide dinucleotide phosphate (see all 18)	53-59-8	--
NADPH	2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)	53-57-6	--
Oxygen	Oxygen (see all 5)	7782-44-7	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

4 DrugBank Compounds for FMO1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Cevimeline	Cevimeline hydrochloride (see all 3)	107233-08-9	enzyme	substrate	11725960 12608011
Cimetidine	--	51481-61-9	enzyme	substrate	19283698 11465082
Tamoxifen	Tamoxifen Citrate (see all 5)	10540-29-1	enzyme	substrate	19515014
Voriconazole	--	137234-62-9	enzyme	substrate	19515014

10/18 Novoseek chemical compound relationships for FMO1 gene (see all 18) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
methyl p-tolyl sulfide	91.7	5	14976351 (2), 10950857 (1), 17942081 (1)
thiobenzamide	80.3	1	9076656 (1)
methimazole	80.2	4	10901713 (1), 9580872 (1), 17942081 (1), 14976351 (1)
n-octylamine	72.5	1	9580872 (1)
imipramine	66.6	4	12527797 (1), 19262426 (1), 9076656 (1)
sulfoxide	66.6	6	12490590 (1), 12642475 (1), 14976351 (1)
nn-dimethylaniline	66.5	1	9076656 (1)
fenthion	64.6	5	17253727 (2), 14976351 (2)
indole-3-carbinol	58.2	6	8886600 (2), 11489435 (2)
chlorpromazine	53	2	16985102 (1), 9076656 (1)

Search CenterWatch for drugs/clinical trials and news about FMO1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FMO1 gene:

NM_002021.1

Unigene Cluster for FMO1:

Flavin containing monooxygenase 1

Hs.1424 [show with all ESTs]

Unigene Representative Sequence: AK097039

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367750(uc009wvz.3 uc010pme.2 uc001ghl.3) ENST00000433267

ENST00000469112 ENST00000354841(uc001ghm.3) ENST00000459868 ENST00000472893

ENST00000469711 ENST00000402921

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Additional cDNA sequence:

AK097039.1 AK290113.1 AK296198.1 AK315100.1 BC047129.1 M64082.1

9 DOTS entries:

DT.452339 DT.121400992 DT.40106093 DT.95335256 DT.100755252 DT.100717139 DT.75181202 DT.95160913

DT.92026409

24/102 AceView cDNA sequences (see all 102):

BX105070 T28483 AI373298 AI261683 AA923069 BQ011599 AK097039 BC047129

CR619998 AI138264 BI765199 AI743988 AI734238 AI460325 M64082 AA863111

R94540 NM_002021 AL544898 AI373066 AA935153 AI566029 AW299273 AI052507

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FMO1 (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b
SP1:					-		-		-		-						-
SP2:																	-
SP3:																																	-
SP4:							-		-		-						-
SP5:							-		-		-

ECgene alternative splicing isoforms for FMO1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FMO1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCCAGTGGG

About this image

FMO1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Adult Endothelial Cells

Blood Brain Barrier, Endothelium

Extraembryonic Mesoderm

Extraembryonic Capillary Plexus

Extraembryonic Angioblasts

Endothelium

Heart

Primitive Heart Tube

Primitive Heart Tube Cells

Myocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Primitive gut tube-like cells (A scalable, suspensi...)

See FMO1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FMO1

SOURCE GeneReport for Unigene cluster: Hs.1424

UniProtKB/Swiss-Prot: FMO1_HUMAN, Q01740

Tissue specificity: Expressed mainly in fetal liver, adult kidney and, to a lesser extent, the intestine

SABiosciences Expression via Pathway-Focused PCR Arrays including FMO1:

Hepatotoxicity in human mouse rat

Drug Metabolism: Phase I Enzymes in human mouse rat

Cellular Stress Responses in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMO1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for FMO1 gene from 5/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	si:dkey-239i20.4⁶ fmo5⁶ (see all 5)	flavin containing monooxygenase 5 (see all 5)	47(a) 47(a) (see all 5)	many ↔ many many ↔ many (see all 5)	20(15120813-15138010) 20(15099468-15110570)
fruit fly (Drosophila melanogaster)	Insecta	Fmo-2³	dimethylaniline monooxygenase (N-oxide forming)	36(a)		42C2 --
worm (Caenorhabditis elegans)	Secernentea	fmo-12³	flavin-containing monoxygenase	41(a) (best of 3)		IV(10682727-10684501) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G12160⁶ AT1G63370⁶ (see all 18)	flavin-containing monooxygenase-like protein (see all 18)	26(a) 25(a) (see all 18)	possible ortholog possible ortholog (see all 18)	1(4126066-4128310) 1(23503205-23505358)
rice (Oryza sativa)	Liliopsida	-- -- (see all 19)	flavin-containing monooxygenase family protein, pu... flavin-containing monooxygenase family protein, pu... (see all 19)	24(a) 24(a) (see all 19)	possible ortholog possible ortholog (see all 19)	7(663612-666146) 6(19618926-19620613)

ENSEMBL Gene Tree for FMO1 (if available)
TreeFam Gene Tree for FMO1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FMO1 gene

FMO2² FMO4² FMO3² FMO5² FMO6P²

6 SIMAP similar genes for FMO1 using alignment to 4 protein entries: FMO1_HUMAN (see all proteins):

DKFZp667E137 FMO2 FMO6P FMO5 FMO3 FMO4

FMO1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs144755906^1,2	C	--	171215656(+)	`TGGTC-/CAACAATGA CAGCATCATCATCATCA`	1	--	int¹		0	--	--	--	--
rs187014843^1,2		--	171215971(+)	`CCCCCA/CACTCC`	1	--	int¹		0	--	--	--	--
rs192984184^1,2		--	171216199(+)	`TACCAC/TGAATT`	1	--	int¹		0	--	--	--	--
rs183600854^1,2		--	171216226(+)	`ATTGAC/TGGGCA`	1	--	int¹		0	--	--	--	--
rs188892514^1,2		--	171216439(+)	`GTTCAC/GCTGGA`	1	--	int¹		0	--	--	--	--
rs193275956^1,2		--	171216494(+)	`CTCCTA/CAAGGA`	1	--	int¹		0	--	--	--	--
rs184750647^1,2		--	171216507(+)	`CCTGTC/GAGATA`	1	--	int¹		0	--	--	--	--
rs114865690^1,2		--	171216672(+)	`GTTTGC/TGTGTT`	1	--	int¹		1		WA	118
rs139596914^1,2		--	171216703(+)	`CACTCA/GCACTT`	1	--	int¹		0	--	--	--	--
rs7520777^1,2	C,F,A	--	171216717(+)	`GCACTG/CACAGT`	1	--	int¹		9		NA WA CSA EA	369

HapMap Linkage Disequilibrium report for FMO1 (171217638 - 171255117 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FMO1
2 CNVs: 70415 70417
Human Gene Mutation Database (HGMD): FMO1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FMO1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FMO1 for disorders           About GeneDecksing

OMIM gene information: 136130    OMIM disorders: --

6 diseases for FMO1:    About MalaCards

trimethylaminuria patent ductus arteriosus amyotrophic lateral sclerosis lateral sclerosis

hearing loss hepatitis

1 Novoseek disease relationship for FMO1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
trimethylaminuria	75.8	1	12678693 (1)

Human Genome Epidemiology (HuGE) Navigator: FMO1 (7 documents)

Export disorders for FMO1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FMO1 gene, integrated from 9 sources (see all 81):
(articles sorted by number of sources associating them with FMO1)

Utopia: connect your pdf to the dynamic
world of online information

Cloning, primary sequence, and chromosomal mapping of a human flavin- containing monooxygenase (FMO1). (PubMed id 1712018)^{1, 2, 9} Dolphin C.T.... Phillips I.R. (1991)
Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. (PubMed id 12527699)^{1, 2, 9} Furnes B.... Schlenk D. (2003)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification of human drug-metabolizing enzymes involved in the metabolism of SNI-2011. (PubMed id 11725960)^{1, 7} Washio T....Yasuda H. (2001)
Immunoquantitation of FMO1 in human liver, kidney, and intestine. (PubMed id 10950857)^{1, 9} Yeung C.K....Rettie A.E. (2000)
Human hepatic flavin-containing monooxygenases 1 (FMO1) and 3 (FMO3) developmental expression. (PubMed id 11809920)^{1, 9} Koukouritaki S.B....Hines R.N. (2002)
Genetic variability at the human FMO1 locus: significance of a basal promoter yin yang 1 element polymorphism (FMO1*6). (PubMed id 12829732)^{1, 9} Hines R.N....McCarver D.G. (2003)
Quantitative analysis of FMO gene mRNA levels in human tissues. (PubMed id 16183778)^{1, 9} Zhang J. and Cashman J.R. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2326	HGNC: 3769	AceView: FMO1	Ensembl:ENSG00000010932	euGenes: HUgn2326
ECgene: FMO1	Kegg: 2326	H-InvDB: FMO1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FMO1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FMO1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/fmo1/

Intellectual Property for FMO1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FMO1 gene:
Search GeneIP for patents involving FMO1

GeneCards and IP:
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flavin containing monooxygenase 1

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FMO1 Gene

flavin containing monooxygenase 1

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