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Aliases for FMO1 Gene

Aliases for FMO1 Gene

  • Flavin Containing Monooxygenase 1 2 3 5
  • EC 1.14.13.8 4 61
  • Fetal Hepatic Flavin-Containing Monooxygenase 1 4
  • Dimethylaniline Oxidase 1 4
  • FMO 1 4

External Ids for FMO1 Gene

Previous GeneCards Identifiers for FMO1 Gene

  • GC01P168781
  • GC01P166846
  • GC01P167798
  • GC01P168457
  • GC01P167949
  • GC01P169484
  • GC01P142440

Summaries for FMO1 Gene

Entrez Gene Summary for FMO1 Gene

  • Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for FMO1 Gene

FMO1 (Flavin Containing Monooxygenase 1) is a Protein Coding gene. Diseases associated with FMO1 include Trimethylaminuria and Kabuki Syndrome 1. Among its related pathways are Tamoxifen Pathway, Pharmacokinetics and Drug metabolism - cytochrome P450. GO annotations related to this gene include oxidoreductase activity and monooxygenase activity. An important paralog of this gene is FMO2.

UniProtKB/Swiss-Prot for FMO1 Gene

  • This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.

Gene Wiki entry for FMO1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FMO1 Gene

Genomics for FMO1 Gene

Regulatory Elements for FMO1 Gene

Enhancers for FMO1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G171247 1.4 Ensembl ENCODE dbSUPER 10.5 +5.1 5065 11.9 NFIB ZSCAN4 BMI1 RAD21 GLIS2 SCRT2 FOS MIXL1 EGR2 ZNF654 FMO2 FMO4 FMO1 ENSG00000231424 GC01M171253 LOC105371611 ENSG00000206692
GH01G171284 1.1 FANTOM5 ENCODE 8.8 +37.7 37726 2.4 JUNB DPF2 FOXA1 ZNF579 GATA3 JUND IKZF1 EED FOSL2 FOS FMO4 FMO1 PRRC2C HMGB1P11
GH01G171263 0.5 ENCODE 10.8 +15.6 15589 2.0 SRF ZFP3 ZNF133 FMO4 FMO1 GC01P171270 GC01M171253 ENSG00000206692
GH01G171295 0.2 ENCODE 8.8 +47.6 47612 0.3 FMO4 FMO1 HMGB1P11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FMO1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FMO1 Gene

Chromosome:
1
Start:
171,248,471 bp from pter
End:
171,285,978 bp from pter
Size:
37,508 bases
Orientation:
Plus strand

Genomic View for FMO1 Gene

Genes around FMO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FMO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FMO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMO1 Gene

Proteins for FMO1 Gene

  • Protein details for FMO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01740-FMO1_HUMAN
    Recommended name:
    Dimethylaniline monooxygenase [N-oxide-forming] 1
    Protein Accession:
    Q01740
    Secondary Accessions:
    • A8K248
    • B7Z3P4
    • Q5QPT2
    • Q9UJC2

    Protein attributes for FMO1 Gene

    Size:
    532 amino acids
    Molecular mass:
    60311 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FMO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FMO1 Gene

Selected DME Specific Peptides for FMO1 Gene

Q01740:
  • FKGQYFHSRQYKHP
  • DFPFPEDYPN
  • PSIKEVKENSV
  • KEMSCYSDFPF
  • WEGARNAI
  • CFERSDD
  • IVFATGYTF
  • DLGGLWRFTEHVEEGRASLY
  • GMGNSGTDIAVE
  • CLEEGLEPTCFE
  • LPLDSFPGI
  • FGPCSPYQFRL
  • FDAVMVCTG
  • SLYKYIFP

Post-translational modifications for FMO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for FMO1 Gene

Suggested Antigen Peptide Sequences for FMO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q01740

UniProtKB/Swiss-Prot:

FMO1_HUMAN :
  • Belongs to the FMO family.
Family:
  • Belongs to the FMO family.
genes like me logo Genes that share domains with FMO1: view

No data available for Gene Families for FMO1 Gene

Function for FMO1 Gene

Molecular function for FMO1 Gene

GENATLAS Biochemistry:
flavin containing monooxygenase 1,microsomal,expressed in fetal liver
UniProtKB/Swiss-Prot CatalyticActivity:
N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot Function:
This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.

Enzyme Numbers (IUBMB) for FMO1 Gene

Gene Ontology (GO) - Molecular Function for FMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IDA 19262426
GO:0004499 N,N-dimethylaniline monooxygenase activity TAS --
GO:0005515 protein binding IPI 25910212
GO:0016491 oxidoreductase activity IEA --
GO:0050660 flavin adenine dinucleotide binding IEA --
genes like me logo Genes that share ontologies with FMO1: view

Animal Model Products

CRISPR Products

miRNA for FMO1 Gene

miRTarBase miRNAs that target FMO1

Inhibitory RNA Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FMO1 Gene

Localization for FMO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMO1 Gene

Microsome membrane. Endoplasmic reticulum membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FMO1 gene
Compartment Confidence
endoplasmic reticulum 5
peroxisome 3
cytosol 2
plasma membrane 1
extracellular 1

Gene Ontology (GO) - Cellular Components for FMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FMO1: view

Pathways & Interactions for FMO1 Gene

genes like me logo Genes that share pathways with FMO1: view

Gene Ontology (GO) - Biological Process for FMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006082 organic acid metabolic process IDA 15144220
GO:0006805 xenobiotic metabolic process TAS --
GO:0006970 response to osmotic stress IEA --
GO:0009404 toxin metabolic process IDA 15144220
GO:0017144 drug metabolic process IEA --
genes like me logo Genes that share ontologies with FMO1: view

No data available for SIGNOR curated interactions for FMO1 Gene

Drugs & Compounds for FMO1 Gene

(17) Drugs for FMO1 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tamoxifen Approved Pharma Antagonist, Enzyme, substrate TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 390
Vandetanib Approved April 2011 Pharma Enzyme, substrate VEGFR, EGFR, and RET inhibitor, EGFR Inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Cevimeline Approved Pharma Enzyme, substrate Muscarinic receptor agonist 5
Cimetidine Approved Pharma Inhibition, Inhibitor, Enzyme, substrate H2 receptor antagonist, H2 antagonist, I1 agonist 75
Voriconazole Approved, Investigational Pharma Enzyme, substrate CYP51 inhibitor 131

(19) Additional Compounds for FMO1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
Dimethylaniline-N-oxide
  • Dimethyl(phenyl)amine oxide
  • Dimethylaniline N-oxide
  • N,N-Dimethylaniline N-oxide
  • Nn-dimethylaniline-N-oxide
874-52-2
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
N,N-Dimethylaniline
  • Dimethylaminobenzene
  • Dimethylaniline
  • Dimethylphenylamine
  • N,N-(Dimethylamino)benzene
  • N,N-Dimethyl-Benzenamine
121-69-7
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
genes like me logo Genes that share compounds with FMO1: view

Transcripts for FMO1 Gene

Unigene Clusters for FMO1 Gene

Flavin containing monooxygenase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FMO1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
SP1: - - - - -
SP2: -
SP3: -
SP4: - - - -
SP5: - - -
SP6: - -
SP7: - -
SP8: - -

Relevant External Links for FMO1 Gene

GeneLoc Exon Structure for
FMO1
ECgene alternative splicing isoforms for
FMO1

Expression for FMO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FMO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FMO1 Gene

This gene is overexpressed in Kidney - Cortex (x14.5) and Minor Salivary Gland (x4.8).

Protein differential expression in normal tissues from HIPED for FMO1 Gene

This gene is overexpressed in Kidney (37.7), Fetal Liver (11.6), and Fetal gut (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FMO1 Gene



NURSA nuclear receptor signaling pathways regulating expression of FMO1 Gene:

FMO1

SOURCE GeneReport for Unigene cluster for FMO1 Gene:

Hs.1424

mRNA Expression by UniProt/SwissProt for FMO1 Gene:

Q01740-FMO1_HUMAN
Tissue specificity: Expressed mainly in fetal liver, adult kidney and, to a lesser extent, the intestine.

Evidence on tissue expression from TISSUES for FMO1 Gene

  • Liver(4.5)
  • Intestine(4.2)
  • Kidney(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FMO1: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FMO1 Gene

Orthologs for FMO1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FMO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FMO1 34 35
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia FMO1 34 35
  • 89.6 (n)
cow
(Bos Taurus)
Mammalia FMO1 34 35
  • 88.1 (n)
mouse
(Mus musculus)
Mammalia Fmo1 34 16 35
  • 84.71 (n)
rat
(Rattus norvegicus)
Mammalia Fmo1 34
  • 84.02 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 75 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 54 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 62 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fmo2 34
  • 59.23 (n)
fruit fly
(Drosophila melanogaster)
Insecta Fmo-2 36
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea fmo-12 36
  • 41 (a)
fmo-15 36
  • 39 (a)
fmo-13 36
  • 38 (a)
Species where no ortholog for FMO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for FMO1 Gene

ENSEMBL:
Gene Tree for FMO1 (if available)
TreeFam:
Gene Tree for FMO1 (if available)

Paralogs for FMO1 Gene

Paralogs for FMO1 Gene

(6) SIMAP similar genes for FMO1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FMO1: view

Variants for FMO1 Gene

Sequence variations from dbSNP and Humsavar for FMO1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000024256 -- 171,263,734(+) ACTCG(G/T)AGTTC intron-variant
rs1000268684 -- 171,247,516(+) TTTAG(A/G)TTCCC intron-variant, upstream-variant-2KB
rs1000421411 -- 171,277,849(+) TTGTA(A/T)TGCCA intron-variant
rs1000451140 -- 171,261,600(+) GCATT(G/T)TGGCC intron-variant
rs1000473138 -- 171,264,569(+) GCCAG(C/T)AGCGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FMO1 Gene

Variant ID Type Subtype PubMed ID
dgv117e212 CNV loss 25503493
esv28731 CNV gain+loss 19812545
esv3578269 CNV loss 25503493
nsv1144416 CNV deletion 24896259
nsv831882 CNV loss 17160897
nsv946500 CNV duplication 23825009

Variation tolerance for FMO1 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.18; 61.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FMO1 Gene

Human Gene Mutation Database (HGMD)
FMO1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FMO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FMO1 Gene

Disorders for FMO1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FMO1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
trimethylaminuria
  • fish malodor syndrome
kabuki syndrome 1
  • kabuki syndrome
- elite association - COSMIC cancer census association via MalaCards
Search FMO1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FMO1

Genetic Association Database (GAD)
FMO1
Human Genome Epidemiology (HuGE) Navigator
FMO1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FMO1
genes like me logo Genes that share disorders with FMO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FMO1 Gene

Publications for FMO1 Gene

  1. Increased incidence of FMO1 gene single nucleotide polymorphisms in sporadic amyotrophic lateral sclerosis. (PMID: 17127561) Cereda C. … Ceroni M. (Amyotroph Lateral Scler 2006) 3 22 46 64
  2. Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. (PMID: 12527699) Furnes B. … Schlenk D. (Drug Metab. Dispos. 2003) 3 4 22 64
  3. Cloning, primary sequence, and chromosomal mapping of a human flavin- containing monooxygenase (FMO1). (PMID: 1712018) Dolphin C.T. … Phillips I.R. (J. Biol. Chem. 1991) 3 4 22 64
  4. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat B.E. … Tseng Z.H. (BMC Cardiovasc Disord 2011) 3 46 64
  5. Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes. (PMID: 20056567) Searles Nielsen S. … Mueller B.A. (Environ. Health Perspect. 2010) 3 46 64

Products for FMO1 Gene

Sources for FMO1 Gene

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