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Aliases for FMNL3 Gene

Aliases for FMNL3 Gene

  • Formin Like 3 2 3 5
  • Formin Homology 2 Domain-Containing Protein 3 3 4
  • Formin-Like 3 2 3
  • FHOD3 3 4
  • WBP-3 3 4
  • FRL2 3 4
  • WBP3 3 4
  • WW Domain Binding Protein 3 3
  • WW Domain-Binding Protein 3 4
  • KIAA2014 4

External Ids for FMNL3 Gene

Previous GeneCards Identifiers for FMNL3 Gene

  • GC12M048317
  • GC12M050031
  • GC12M047063

Summaries for FMNL3 Gene

Entrez Gene Summary for FMNL3 Gene

  • The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for FMNL3 Gene

FMNL3 (Formin Like 3) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and Mitotic Prometaphase. GO annotations related to this gene include binding and Rho GTPase binding. An important paralog of this gene is FMNL2.

UniProtKB/Swiss-Prot for FMNL3 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement.

Gene Wiki entry for FMNL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FMNL3 Gene

Genomics for FMNL3 Gene

Regulatory Elements for FMNL3 Gene

Enhancers for FMNL3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FMNL3 on UCSC Golden Path with GeneCards custom track

Promoters for FMNL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FMNL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for FMNL3 Gene

Chromosome:
12
Start:
49,636,499 bp from pter
End:
49,708,165 bp from pter
Size:
71,667 bases
Orientation:
Minus strand

Genomic View for FMNL3 Gene

Genes around FMNL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FMNL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FMNL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMNL3 Gene

Proteins for FMNL3 Gene

  • Protein details for FMNL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVF7-FMNL3_HUMAN
    Recommended name:
    Formin-like protein 3
    Protein Accession:
    Q8IVF7
    Secondary Accessions:
    • B0JZA7
    • Q6ZRJ1

    Protein attributes for FMNL3 Gene

    Size:
    1028 amino acids
    Molecular mass:
    117213 Da
    Quaternary structure:
    • Interacts with SRGAP2 (via SH3 domain).
    SequenceCaution:
    • Sequence=BAC23110.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FMNL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FMNL3 Gene

Proteomics data for FMNL3 Gene at MOPED

Post-translational modifications for FMNL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FMNL3 Gene

No data available for DME Specific Peptides for FMNL3 Gene

Domains & Families for FMNL3 Gene

Protein Domains for FMNL3 Gene

Suggested Antigen Peptide Sequences for FMNL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IVF7

UniProtKB/Swiss-Prot:

FMNL3_HUMAN :
  • The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
  • Belongs to the formin homology family.
Domain:
  • The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
  • Contains 1 DAD (diaphanous autoregulatory) domain.
  • Contains 1 FH2 (formin homology 2) domain.
  • Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
Family:
  • Belongs to the formin homology family.
genes like me logo Genes that share domains with FMNL3: view

No data available for Gene Families for FMNL3 Gene

Function for FMNL3 Gene

Molecular function for FMNL3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement.

Gene Ontology (GO) - Molecular Function for FMNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with FMNL3: view
genes like me logo Genes that share phenotypes with FMNL3: view

Animal Models for FMNL3 Gene

MGI Knock Outs for FMNL3:

Animal Model Products

miRNA for FMNL3 Gene

miRTarBase miRNAs that target FMNL3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FMNL3 Gene

Localization for FMNL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMNL3 Gene

Cytoplasm. Cell membrane; Lipid-anchor. Note=Enriched in lamellipodia.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FMNL3 Gene COMPARTMENTS Subcellular localization image for FMNL3 gene
Compartment Confidence
cytosol 5
plasma membrane 4
mitochondrion 3
golgi apparatus 2
nucleus 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for FMNL3 Gene

Pathways & Interactions for FMNL3 Gene

genes like me logo Genes that share pathways with FMNL3: view

Pathways by source for FMNL3 Gene

Gene Ontology (GO) - Biological Process for FMNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0016477 cell migration IMP 21834987
GO:0030036 actin cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with FMNL3: view

No data available for SIGNOR curated interactions for FMNL3 Gene

Drugs & Compounds for FMNL3 Gene

No Compound Related Data Available

Transcripts for FMNL3 Gene

Unigene Clusters for FMNL3 Gene

Formin-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FMNL3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - -
SP2:
SP3:
SP4: -

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for FMNL3 Gene

GeneLoc Exon Structure for
FMNL3
ECgene alternative splicing isoforms for
FMNL3

Expression for FMNL3 Gene

mRNA expression in normal human tissues for FMNL3 Gene

Protein differential expression in normal tissues from HIPED for FMNL3 Gene

This gene is overexpressed in Bone (13.1), Fetal gut (12.1), Pancreas (10.5), Placenta (6.4), and Fetal heart (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FMNL3 Gene



SOURCE GeneReport for Unigene cluster for FMNL3 Gene Hs.179838

mRNA Expression by UniProt/SwissProt for FMNL3 Gene

Q8IVF7-FMNL3_HUMAN
Tissue specificity: Expressed in endothelial cells.
genes like me logo Genes that share expression patterns with FMNL3: view

Protein tissue co-expression partners for FMNL3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FMNL3 Gene

Orthologs for FMNL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FMNL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FMNL3 35
  • 91.89 (n)
  • 98.02 (a)
FMNL3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FMNL3 35
  • 92.17 (n)
  • 98.36 (a)
FMNL3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fmnl3 35
  • 89.72 (n)
  • 96.68 (a)
Fmnl3 16
Fmnl3 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FMNL3 35
  • 98.52 (n)
  • 98.59 (a)
FMNL3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fmnl3 35
  • 89.93 (n)
  • 96.37 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia FMNL3 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FMNL3 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fmnl3 35
  • 74.15 (n)
  • 81.74 (a)
Str.12987 35
zebrafish
(Danio rerio)
Actinopterygii wufa31c06 35
fmnl3 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG32138 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea frl-1 36
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BNR1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2508 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for FMNL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FMNL3 Gene

ENSEMBL:
Gene Tree for FMNL3 (if available)
TreeFam:
Gene Tree for FMNL3 (if available)

Paralogs for FMNL3 Gene

Paralogs for FMNL3 Gene

(4) SIMAP similar genes for FMNL3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FMNL3: view

Variants for FMNL3 Gene

Sequence variations from dbSNP and Humsavar for FMNL3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7137976 -- 49,705,284(+) CCCCC(A/G)TTTGA intron-variant
rs7299002 -- 49,701,676(+) cagca(C/T)tttgg intron-variant
rs7299820 -- 49,654,139(+) TGATA(C/T)GGCTA intron-variant
rs7300582 -- 49,654,592(+) ACCTA(A/G)CCAAA intron-variant
rs10875964 -- 49,687,127(+) TCTCA(C/T)TCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FMNL3 Gene

Variant ID Type Subtype PubMed ID
nsv832406 CNV Loss 17160897
esv2745865 CNV Deletion 23290073
esv2674876 CNV Deletion 23128226
esv25495 CNV Loss 19812545

Variation tolerance for FMNL3 Gene

Residual Variation Intolerance Score: 7.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FMNL3 Gene

Disorders for FMNL3 Gene

Relevant External Links for FMNL3

Genetic Association Database (GAD)
FMNL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FMNL3

No disorders were found for FMNL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FMNL3 Gene

Publications for FMNL3 Gene

  1. Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico. (PMID: 12684686) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 4 23 67
  2. The formin FMNL3 assembles plasma membrane protrusions that participate in cell-cell adhesion. (PMID: 25428984) Gauvin T.J. … Higgs H.N. (Mol. Biol. Cell 2015) 3
  3. Increased expression of formin-like 3 contributes to metastasis and poor prognosis in colorectal carcinoma. (PMID: 25758200) Zeng Y.F. … Xin H.B. (Exp. Mol. Pathol. 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for FMNL3 Gene

Sources for FMNL3 Gene

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