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FMNL3 Gene

protein-coding   GIFtS: 52
GCID: GC12M050031

Formin-Like 3

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Formin-Like 31 2     Formin-Like Protein 32
Formin Homology 2 Domain-Containing Protein 32 3     WW Domain Binding Protein 32
FHOD32 3     KIAA20143
WBP-32 3     WW Domain-Binding Protein 33
WBP32 3     

External Ids:    HGNC: 236981   Entrez Gene: 910102   Ensembl: ENSG000001617917   UniProtKB: Q8IVF73   

Export aliases for FMNL3 gene to outside databases

Previous GC identifers: GC12M048317 GC12M047063


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FMNL3 Gene:
The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse
Wbp3 protein. Two alternative transcripts encoding different isoforms have been described. (provided by RefSeq,
Jul 2008)

GeneCards Summary for FMNL3 Gene:
FMNL3 (formin-like 3) is a protein-coding gene. Diseases associated with FMNL3 include chondrosarcoma. GO annotations related to this gene include actin binding and GTPase activating protein binding. An important paralog of this gene is DAAM1.

UniProtKB/Swiss-Prot: FMNL3_HUMAN, Q8IVF7
Function: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control
of cell shape and migration

Gene Wiki entry for FMNL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FMNL3 gene promoter:
         AML1a   SREBP-1c   CUTL1   NF-E2 p45   Evi-1   SREBP-1b   CREB   SREBP-1a   deltaCREB   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFMNL3 promoter sequence
   Search Chromatin IP Primers for FMNL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FMNL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.12   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13.12

FMNL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FMNL3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M050031:  view genomic region     (about GC identifiers)

Start:
50,031,724 bp from pter      End:
50,101,948 bp from pter
Size:
70,225 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FMNL3_HUMAN, Q8IVF7 (See protein sequence)
Recommended Name: Formin-like protein 3  
Size: 1028 amino acids; 117213 Da
Subunit: Interacts with SRGAP2 (via SH3 domain)
Sequence caution: Sequence=BAC23110.2; Type=Erroneous initiation;
Secondary accessions: B0JZA7 Q6ZRJ1
Alternative splicing: 3 isoforms:  Q8IVF7-1   Q8IVF7-2   Q8IVF7-3   

Explore the universe of human proteins at neXtProt for FMNL3: NX_Q8IVF7

Explore proteomics data for FMNL3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FMNL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_783863.4  NP_944489.2  

    ENSEMBL proteins: 
     ENSP00000335655   ENSP00000447479   ENSP00000344311   ENSP00000448939   ENSP00000293590  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR010473 GTPase-bd
     IPR010472 FH3_dom
     IPR015425 FH2_Formin
     IPR027655 Fmnl3
     IPR014768 GTPase-bd/formin_homology_3

    Graphical View of Domain Structure for InterPro Entry Q8IVF7

    ProtoNet protein and cluster: Q8IVF7

    2 Blocks protein domains:
    IPB003104 Actin-binding FH2
    IPB010472 Diaphanous FH3


    UniProtKB/Swiss-Prot: FMNL3_HUMAN, Q8IVF7
    Domain: The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This
    autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2
    domain to then nucleate and elongate nonbranched actin filaments (By similarity)
    Similarity: Belongs to the formin homology family
    Similarity: Contains 1 DAD (diaphanous autoregulatory) domain
    Similarity: Contains 1 FH2 (formin homology 2) domain
    Similarity: Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain


    FMNL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FMNL3_HUMAN, Q8IVF7
    Function: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control
    of cell shape and migration

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005488binding ----
    GO:0005515protein binding ----
    GO:0017048Rho GTPase binding IEA--
    GO:0032794GTPase activating protein binding ISS--
         
    FMNL3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FMNL3:
     Increased cell number in G1, s 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FMNL3
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    miRTarBase miRNAs that target FMNL3:
    hsa-mir-155-5p (MIRT020759), hsa-mir-125b-5p (MIRT046050), hsa-mir-1 (MIRT023798), hsa-mir-182-5p (MIRT047179)

    Block miRNA regulation of human, mouse, rat FMNL3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FMNL3 (see all 118):
    hsa-miR-124* hsa-miR-642a hsa-miR-520e hsa-miR-520f hsa-miR-1914* hsa-miR-15a hsa-miR-106a hsa-miR-1258
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FMNL3_HUMAN, Q8IVF7: Cytoplasm. Note=Enriched in lamellipodia
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    cytoskeleton1
    golgi apparatus1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--

    FMNL3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FMNL3
    Interactions:

        Search GeneGlobe Interaction Network for FMNL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FMNL3 (Q8IVF72, 3 ENSP000003356554) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF40AO754002, 3MINT-61862 I2D: score=4 
    YWHABP319463I2D: score=1 
    SPRY2ENSP000003663064STRING: ENSP00000366306
    FMNL1ENSP000003292194STRING: ENSP00000329219
    LAPTM4AENSP000001750914STRING: ENSP00000175091
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization IMP--
    GO:0008360regulation of cell shape IMP--
    GO:0016043cellular component organization ----
    GO:0016477cell migration IMP--
    GO:0030036actin cytoskeleton organization IEA--

    FMNL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FMNL3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FMNL3 gene (2 alternative transcripts): 
    NM_175736.4  NM_198900.2  

    Unigene Cluster for FMNL3:

    Formin-like 3
    Hs.179838  [show with all ESTs]
    Unigene Representative Sequence: BC159100
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335154(uc001rut.1 uc001ruu.1 uc001ruv.1 uc001ruw.1)
    ENST00000550668 ENST00000550488 ENST00000549137 ENST00000352151 ENST00000550970
    ENST00000550424 ENST00000293590
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FMNL3 (see all 118):
    hsa-miR-124* hsa-miR-642a hsa-miR-520e hsa-miR-520f hsa-miR-1914* hsa-miR-15a hsa-miR-106a hsa-miR-1258
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FMNL3
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      QuantiFast Probe-based Assays in human, mouse, rat FMNL3

    Additional mRNA sequence: 

    AB095934.2 AK095874.1 AK127200.1 AK128195.1 AL162062.1 BC033181.1 BC090955.1 BC159100.1 

    17 DOTS entries:

    DT.97766348  DT.101983531  DT.100746293  DT.111068  DT.101967800  DT.40297212  DT.100738140  DT.100746292 
    DT.214095  DT.95147860  DT.100701599  DT.100763219  DT.108331  DT.408801  DT.91759955  DT.95074705 
    DT.95151344 

    Selected AceView cDNA sequences (see all 156):

    NM_175736 CA433961 AI417122 AI423232 NM_198900 CR596925 BM726881 AI586934 
    BX379914 CF147437 BF929239 BM918131 AI216096 AW024256 AK128195 BM821657 
    BX092766 BQ425280 AI022391 BG035846 BE551357 BQ378216 BC033181 BX644656 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FMNL3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:              -                                                                             -                                                               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:        -                                                                                                                                                   

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28
    SP1:                    -         
    SP2:                    -         
    SP3:                              
    SP4:                              


    ECgene alternative splicing isoforms for FMNL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FMNL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FMNL3 Expression
    About this image

    FMNL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FMNL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.179838
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMNL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FMNL3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fmnl31 , 5 formin-like 31, 5 89.72(n)1
    96.68(a)1
      15 (56.13 cM)5
    223791  NM_011711.11  NP_035841.11 
     993172255 
    lizard
    (Anolis carolinensis)
    Reptilia FMNL36
    formin-like 3
    84(a)
    1 ↔ 1
    2(94694702-94811311)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.129872 Transcribed sequence with moderate similarity to protein more 74.47(n)    BX774708.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa31c062 Transcribed sequence with moderate similarity to protein more 75.08(n)    57045631 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG321386
    --
    39(a)
    1 → many
    3L(14046796-14064683)
    worm
    (Caenorhabditis elegans)
    Secernentea frl-16
    Protein FRL-1 (frl-1) mRNA, complete cds
    32(a)
    1 → many
    III(2134475-2151554) WBGene00021698


    ENSEMBL Gene Tree for FMNL3 (if available)
    TreeFam Gene Tree for FMNL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FMNL3 gene
    DAAM12  DIAPH12  FHDC12  FMNL12  DAAM22  INF22  FMNL22  GRID2IP2  
    FMN12  DIAPH22  FMN22  DIAPH32  
    4 SIMAP similar genes for FMNL3 using alignment to 4 protein entries:     FMNL3_HUMAN (see all proteins):
    DKFZp762B245    FMNL2    FLJ00304    FMNL1

    FMNL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FMNL3 (see all 1154)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs111690961,2
    C,F--50039209(+) CAGAGC/TTGACC 2 -- ut313Minor allele frequency- T:0.01NA WA 122
    rs1509532661,2
    C--50039246(+) AAAAAG/TAAAGA 2 -- ut310--------
    rs1407363991,2
    C--50039310(+) CCCTGC/TTTAGG 2 -- ut310--------
    rs617435411,2
    F--50039319(+) GGCTAA/GGGCTG 2 -- ut311Minor allele frequency- G:0.02NS 62
    rs1386700441,2
    --50039397(+) GGGGCA/CAAGTG 2 -- ut310--------
    rs771512101,2
    C,F--50039479(+) GAGCTG/AGGGCG 2 -- ut312Minor allele frequency- A:0.07WA NA 238
    rs1913255361,2
    --50039506(+) CAACAC/TAGCCC 2 -- ut310--------
    rs2008716171,2
    C--50039634(+) CTGGGC/TGGTGC 4 P syn10--------
    rs2016546751,2
    C--50039668(+) CAACCA/GTAGGC 4 T M mis10--------
    rs769590171,2
    C,F--50039821(+) GGCTTG/CAGGGG 2 -- int11Minor allele frequency- C:0.02EA 120

    HapMap Linkage Disequilibrium report for FMNL3 (50031724 - 50101948 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FMNL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674876CNV Deletion23128226
    esv2745865CNV Deletion23290073
    esv25495CNV Loss19812545
    nsv832406CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for FMNL3:    
    About MalaCards
    chondrosarcoma

    1 disease from the University of Copenhagen DISEASES database for FMNL3:
    Chondrosarcoma

    FMNL3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for FMNL3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondrosarcoma 67.3 1 12684686 (1)
    glioblastoma 56.4 1 12684686 (1)

    Genetic Association Database (GAD): FMNL3

    Export disorders for FMNL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FMNL3 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with FMNL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico. (PubMed id 12684686)1, 2, 3, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2003)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The formin FMNL3 is a cytoskeletal regulator of angiogenesis. (PubMed id 22275430)1 Hetheridge C....Mellor H. (J. Cell. Sci. 2012)
    4. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O.... Lill R. (Science 2012)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Protein N-myristoylation is required for cellular morphological changes induced by two formin family proteins, FMNL2 and FMNL3. (PubMed id 22790947)1 Moriya K....Utsumi T. (Biosci. Biotechnol. Biochem. 2012)
    7. Bi-modal regulation of a formin by srGAP2. (PubMed id 21148482)2 Mason F.M.... Soderling S.H. (J. Biol. Chem. 2011)
    8. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PubMed id 21834987)2 Bai S.W.... Ridley A.J. (BMC Biol. 2011)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 91010 HGNC: 23698 AceView: FMNL3 Ensembl:ENSG00000161791 euGenes: HUgn91010
    ECgene: FMNL3 H-InvDB: FMNL3

    (According to HUGE)
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    HUGE: KIAA2014

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FMNL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FMNL3 gene:
    Search GeneIP for patents involving FMNL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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