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Aliases for FMNL3 Gene

Aliases for FMNL3 Gene

  • Formin-Like 3 2 3
  • Formin Homology 2 Domain-Containing Protein 3 3 4
  • FHOD3 3 4
  • WBP-3 3 4
  • WBP3 3 4
  • WW Domain Binding Protein 3 3
  • WW Domain-Binding Protein 3 4
  • Formin-Like Protein 3 3
  • KIAA2014 4
  • FRL2 3

External Ids for FMNL3 Gene

Previous GeneCards Identifiers for FMNL3 Gene

  • GC12M048317
  • GC12M050031
  • GC12M047063

Summaries for FMNL3 Gene

Entrez Gene Summary for FMNL3 Gene

  • The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for FMNL3 Gene

FMNL3 (Formin-Like 3) is a Protein Coding gene. GO annotations related to this gene include actin binding and GTPase activating protein binding. An important paralog of this gene is FMN2.

UniProtKB/Swiss-Prot for FMNL3 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration.

Gene Wiki entry for FMNL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FMNL3 Gene

Genomics for FMNL3 Gene

Regulatory Elements for FMNL3 Gene

Genomic Location for FMNL3 Gene

Start:
49,636,499 bp from pter
End:
49,708,165 bp from pter
Size:
71,667 bases
Orientation:
Minus strand

Genomic View for FMNL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FMNL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMNL3 Gene

Proteins for FMNL3 Gene

  • Protein details for FMNL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVF7-FMNL3_HUMAN
    Recommended name:
    Formin-like protein 3
    Protein Accession:
    Q8IVF7
    Secondary Accessions:
    • B0JZA7
    • Q6ZRJ1

    Protein attributes for FMNL3 Gene

    Size:
    1028 amino acids
    Molecular mass:
    117213 Da
    Quaternary structure:
    • Interacts with SRGAP2 (via SH3 domain).
    SequenceCaution:
    • Sequence=BAC23110.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FMNL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FMNL3 Gene

Proteomics data for FMNL3 Gene at MOPED

Post-translational modifications for FMNL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FMNL3 Gene

No data available for DME Specific Peptides for FMNL3 Gene

Domains for FMNL3 Gene

Suggested Antigen Peptide Sequences for FMNL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IVF7

UniProtKB/Swiss-Prot:

FMNL3_HUMAN :
  • Q8IVF7
Domain:
  • The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
  • Contains 1 DAD (diaphanous autoregulatory) domain.
  • Contains 1 FH2 (formin homology 2) domain.
  • Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
Family:
  • Belongs to the formin homology family.
genes like me logo Genes that share domains with FMNL3: view

No data available for Gene Families for FMNL3 Gene

Function for FMNL3 Gene

Molecular function for FMNL3 Gene

UniProtKB/Swiss-Prot Function: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration.

Gene Ontology (GO) - Molecular Function for FMNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005488 binding --
GO:0005515 protein binding --
GO:0017048 Rho GTPase binding IEA --
GO:0032794 GTPase activating protein binding ISS --
genes like me logo Genes that share ontologies with FMNL3: view

Phenotypes for FMNL3 Gene

GenomeRNAi human phenotypes for FMNL3:
genes like me logo Genes that share phenotypes with FMNL3: view

miRNA for FMNL3 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FMNL3 Gene

Localization for FMNL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMNL3 Gene

Cytoplasm. Note=Enriched in lamellipodia.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FMNL3 Gene COMPARTMENTS Subcellular localization image for FMNL3 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FMNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21834987
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FMNL3: view

Pathways for FMNL3 Gene

SuperPathways for FMNL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FMNL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IMP 21834987
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0008360 regulation of cell shape IMP 21834987
GO:0016043 cellular component organization --
GO:0016477 cell migration IMP 21834987
genes like me logo Genes that share ontologies with FMNL3: view

No data available for Pathways by source for FMNL3 Gene

Transcripts for FMNL3 Gene

Unigene Clusters for FMNL3 Gene

Formin-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FMNL3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - -
SP2:
SP3:
SP4: -

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for FMNL3 Gene

GeneLoc Exon Structure for
FMNL3
ECgene alternative splicing isoforms for
FMNL3

Expression for FMNL3 Gene

mRNA expression in normal human tissues for FMNL3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FMNL3 Gene

SOURCE GeneReport for Unigene cluster for FMNL3 Gene Hs.179838

genes like me logo Genes that share expressions with FMNL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FMNL3 Gene

Orthologs for FMNL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FMNL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FMNL3 35
  • 98.52 (n)
  • 98.59 (a)
FMNL3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FMNL3 35
  • 91.89 (n)
  • 98.02 (a)
FMNL3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FMNL3 35
  • 92.17 (n)
  • 98.36 (a)
FMNL3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fmnl3 35
  • 89.72 (n)
  • 96.68 (a)
Fmnl3 16
Fmnl3 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FMNL3 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fmnl3 35
  • 89.93 (n)
  • 96.37 (a)
lizard
(Anolis carolinensis)
Reptilia FMNL3 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fmnl3 35
  • 74.15 (n)
  • 81.74 (a)
Str.12987 35
zebrafish
(Danio rerio)
Actinopterygii fmnl3 36
  • 75 (a)
OneToOne
wufa31c06 35
fruit fly
(Drosophila melanogaster)
Insecta CG32138 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea frl-1 36
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BNR1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2508 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for FMNL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FMNL3 Gene

ENSEMBL:
Gene Tree for FMNL3 (if available)
TreeFam:
Gene Tree for FMNL3 (if available)

Paralogs for FMNL3 Gene

Selected SIMAP similar genes for FMNL3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FMNL3: view

Variants for FMNL3 Gene

Sequence variations from dbSNP and Humsavar for FMNL3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1317663 -- 49,657,265(-) TGTCC(A/G)GGTGA intron-variant
rs1574326 -- 49,696,760(+) TATCT(C/T)CCTCT intron-variant
rs2336058 -- 49,697,097(+) AGATT(C/G)AGAAC intron-variant
rs2878532 -- 49,657,836(-) GGTCC(C/G)ATGGC intron-variant
rs3841320 -- 49,647,028(-) TCCCC(-/C)TCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FMNL3 Gene

Variant ID Type Subtype PubMed ID
nsv832406 CNV Loss 17160897
esv2745865 CNV Deletion 23290073
esv2674876 CNV Deletion 23128226
esv25495 CNV Loss 19812545

Relevant External Links for FMNL3 Gene

HapMap Linkage Disequilibrium report
FMNL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FMNL3 Gene

Disorders for FMNL3 Gene

(1) University of Copenhagen DISEASES for FMNL3 Gene

(2) Novoseek inferred disease relationships for FMNL3 Gene

Disease -log(P) Hits PubMed IDs
chondrosarcoma 67.3 1
glioblastoma 56.4 1

Relevant External Links for FMNL3

Genetic Association Database (GAD)
FMNL3
genes like me logo Genes that share disorders with FMNL3: view

No data available for UniProtKB/Swiss-Prot for FMNL3 Gene

Publications for FMNL3 Gene

  1. Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico. (PMID: 12684686) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PMID: 21834987) Bai S.W. … Ridley A.J. (BMC Biol. 2011) 3 4
  4. The formin FMNL3 is a cytoskeletal regulator of angiogenesis. (PMID: 22275430) Hetheridge C. … Mellor H. (J. Cell. Sci. 2012) 3
  5. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PMID: 22678362) Stehling O. … Lill R. (Science 2012) 3

Products for FMNL3 Gene

Sources for FMNL3 Gene

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