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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FMNL2 Gene

protein-coding   GIFtS: 56
GCID: GC02P153191

Formin-Like 2

(Previous name: formin homology 2 domain containing 2)
(Previous symbol: FHOD2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Formin-Like 21 2
FHOD21 2 3
Formin Homology 2 Domain Containing 21 2
Formin Homology 2 Domain-Containing Protein 22 3
Formin-Like Protein 22
KIAA19023

External Ids:    HGNC: 182671   Entrez Gene: 1147932   Ensembl: ENSG000001578277   UniProtKB: Q96PY53   

Export aliases for FMNL2 gene to outside databases

Previous GC identifers: GC02U900457 GC02P153395 GC02P153017 GC02P152899 GC02P145077


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FMNL2 Gene:
This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis,
cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been
described but their full-length nature has yet to be determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for FMNL2 Gene: 
FMNL2 (formin-like 2) is a protein-coding gene. Diseases associated with FMNL2 include chondrosarcoma, and colorectal cancer. GO annotations related to this gene include Rho GTPase binding and actin binding. An important paralog of this gene is DAAM1.

UniProtKB/Swiss-Prot: FMNL2_HUMAN, Q96PY5
Function: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the
cortical actin filament dynamics

Gene Wiki entry for FMNL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FMNL2 gene promoter:
         AML1a   p53   Pax-6   HNF-3beta   POU3F2   FOXL1   AREB6   S8   Zic1   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFMNL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FMNL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FMNL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q23.3   Ensembl cytogenetic band:  2q23.3   HGNC cytogenetic band: 2q23.3

FMNL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FMNL2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P153191:  view genomic region     (about GC identifiers)

Start:
153,191,751 bp from pter      End:
153,506,348 bp from pter
Size:
314,598 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FMNL2_HUMAN, Q96PY5 (See protein sequence)
Recommended Name: Formin-like protein 2  
Size: 1086 amino acids; 123321 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAI13879.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Sequence=AAI14439.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=AAX88959.1; Type=Erroneous
gene model prediction; Sequence=BAB67795.1; Type=Erroneous initiation;
Secondary accessions: B2RZH5 Q14CC9 Q4ZG52 Q8N3E0
Alternative splicing: 2 isoforms:  Q96PY5-1   Q96PY5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FMNL2: NX_Q96PY5

Explore proteomics data for FMNL2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96PY5

  • FMNL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FMNL2 Protein Expression
    REFSEQ proteins: NP_443137.2  
    ENSEMBL proteins: 
     ENSP00000288670   ENSP00000418959  

    Human Recombinant Protein Products for FMNL2: 
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    Novus Biologicals FMNL2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FMNL2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    FMNL2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for FMNL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/8 InterPro protein domains (see all 8):
     IPR010473 Drf_GTPase-bd
     IPR010472 Drf_FH3
     IPR015425 FH2_actin-bd
     IPR014767 Diaphanous_autoregulatory
     IPR003104 Actin-bd_FH2/DRF_autoreg

    Graphical View of Domain Structure for InterPro Entry Q96PY5

    ProtoNet protein and cluster: Q96PY5

    3 Blocks protein domains:
    IPB001950 Translation initiation factor SUI1
    IPB003104 Actin-binding FH2
    IPB010472 Diaphanous FH3


    UniProtKB/Swiss-Prot: FMNL2_HUMAN, Q96PY5
    Domain: The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This
    autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2
    domain to then nucleate and elongate nonbranched actin filaments (By similarity)
    Similarity: Belongs to the formin homology family
    Similarity: Contains 1 DAD (diaphanous autoregulatory) domain
    Similarity: Contains 1 FH2 (formin homology 2) domain
    Similarity: Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain


    FMNL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FMNL2_HUMAN, Q96PY5
    Function: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the
    cortical actin filament dynamics

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005488binding ----
    GO:0017048Rho GTPase binding IEA--
         
    FMNL2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FMNL2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FMNL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FMNL2 
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    miRNA
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    miRTarBase miRNAs that target FMNL2:
    hsa-mir-155 (MIRT001547)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FMNL2
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate FMNL2 (see all 45):
    hsa-miR-548j hsa-miR-3607-3p hsa-miR-300 hsa-miR-3653 hsa-miR-508-3p hsa-miR-124 hsa-miR-548a-5p hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidFMNL2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMNL2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FMNL2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for FMNL2 (Q96PY52, 3 ENSP000002886704) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF40AO754002, 3MINT-61867 I2D: score=3 
    CDC42P609533, ENSP000003144584I2D: score=3 STRING: ENSP00000314458
    UBCENSP000003448184STRING: ENSP00000344818
    --ENSP000004020944STRING: ENSP00000402094
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization IMP--
    GO:0016043cellular component organization ----
    GO:0022604regulation of cell morphogenesis IMP--
    GO:0030036actin cytoskeleton organization ----
    GO:0030866cortical actin cytoskeleton organization IMP--

    FMNL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FMNL2

    Search CenterWatch for drugs/clinical trials and news about FMNL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FMNL2 gene (4 alternative transcripts): 
    NM_052905.3  NM_001004417.1  NM_001004421.1  NM_001004422.1  

    Unigene Cluster for FMNL2:

    Formin-like 2
    Hs.654630  [show with all ESTs]
    Unigene Representative Sequence: NM_052905
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000288670(uc002tye.3 uc002tyf.3) ENST00000492942 ENST00000475377(uc010fob.3)
    ENST00000497192
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FMNL2
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate FMNL2 (see all 45):
    hsa-miR-548j hsa-miR-3607-3p hsa-miR-300 hsa-miR-3653 hsa-miR-508-3p hsa-miR-124 hsa-miR-548a-5p hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidFMNL2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: FMNL2 (NM_052905)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FMNL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FMNL2
    Sirion Biotech Customized lentivirus for stable overexpression of FMNL2 
                         Customized lentivirus expression plasmids for stable overexpression of FMNL2 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FMNL2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FMNL2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FMNL2

    Additional mRNA sequence: 

    AB067489.1 AK094865.1 AK131316.1 AL834396.1 BC014343.1 BC036492.2 BC113878.1 BC114438.1 
    BC126995.1 BC127621.1 BC128084.1 BC167159.1 

    11 DOTS entries:

    DT.99961199  DT.91966515  DT.95275492  DT.100782348  DT.100011998  DT.120999787  DT.95275494  DT.120999784 
    DT.40201963  DT.91920142  DT.40110934 

    24/147 AceView cDNA sequences (see all 147):

    BM557338 AW303881 AV727666 BM726119 NM_001004421 AA605038 AI370547 CA389003 
    BM768089 BM682552 NM_001004417 AA449419 AW589866 AI984743 BU631977 AA022985 
    NM_052905 AK131316 BM785610 AI867578 AA421752 BF512402 AI656379 AI923431 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FMNL2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^
    SP1:                                      -                       -                                                                                             
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c
    SP1:                    -     -     -                     
    SP2:                    -                                 
    SP3:                          -     -                     
    SP4:                                                      
    SP5:                    -           -                     


    ECgene alternative splicing isoforms for FMNL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FMNL2 expression in normal human tissues (normalized intensities)      FMNL2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCATATGAGC
    FMNL2 Expression
    About this image


    FMNL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See FMNL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FMNL2

    SOURCE GeneReport for Unigene cluster: Hs.654630
        SABiosciences Custom PCR Arrays for FMNL2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FMNL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMNL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FMNL2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fmnl21 , 5 formin-like 21, 5 90.16(n)1
    96.22(a)1
      2 (30.69 cM)5
    714091  NM_172409.21  NP_765997.21 
     528578605 
    chicken
    (Gallus gallus)
    Aves FMNL21 formin-like 2 81.85(n)
    93.98(a)
      771739  XM_001234980.2  XP_001234981.2 
    lizard
    (Anolis carolinensis)
    Reptilia FMNL26
    formin-like 2
    87(a)
    1 ↔ 1
    GL343296.1(1051750-1282751)
    zebrafish
    (Danio rerio)
    Actinopterygii fmnl2a1 formin-like 2a 73.91(n)
    83.16(a)
      100006456  XM_001345159.4  XP_001345195.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG321381 CG32138 53.51(n)
    48.93(a)
      39561  NM_168575.2  NP_729954.2 
    worm
    (Caenorhabditis elegans)
    Secernentea frl-11 Protein FRL-1 46.89(n)
    36.9(a)
      175346  NM_065104.5  NP_497505.3 


    ENSEMBL Gene Tree for FMNL2 (if available)
    TreeFam Gene Tree for FMNL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FMNL2 gene
    DAAM12  DIAPH12  FMNL32  FHDC12  FMNL12  DAAM22  INF22  GRID2IP2  
    FMN12  DIAPH22  FMN22  DIAPH32  
    3 SIMAP similar genes for FMNL2 using alignment to 3 protein entries:     FMNL2_HUMAN (see all proteins):
    DKFZp762B245    FMNL3    FMNL1

    FMNL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6376 SNPs in FMNL2 are shown (see all 6376)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs722815631,2
    C--145096991(+) TCTGT-/TTGA  
            
    TTAAC
    1 -- int10--------
    rs347356741,2
    C--145385768(+) TGTCT-/GTAATCC 1 -- int11Minor allele frequency- GT:0.00NA 2
    rs359533681,2
    C,F--153189893(+) AAGACG/ATAAGG 1 -- us2k19Minor allele frequency- A:0.34WA NA CSA EA 370
    rs1444304241,2
    --153189899(+) TAAGGA/GGAGAA 1 -- us2k10--------
    rs46641001,2
    C,F,A,H--153190223(+) CTTTGG/ATACAA 1 -- us2k1 tfbs322Minor allele frequency- A:0.46NS EA NA WA CSA 2350
    rs1451185571,2
    C--153190265(+) CAGAAC/TTTTAA 1 -- us2k10--------
    rs1484120021,2
    --153190277(+) TTGAAA/TTTATT 1 -- us2k10--------
    rs621795251,2
    F--153190340(+) ATGTAC/TTTGTG 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1450419131,2
    --153190361(+) TCATAC/TGCTTT 1 -- us2k10--------
    rs1929437431,2
    --153190408(+) TGGGCA/GTCTAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FMNL2 (153191751 - 153441751 bp, first 250kb of FMNL2)

    Structural Variations
         Database of Genomic Variants (DGV) 10/25 variations for FMNL2 (see all 25):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2720970CNV Deletion23290073
    esv2665352CNV Deletion23128226
    esv2720969CNV Deletion23290073
    esv1998324CNV Deletion18987734
    esv2671971CNV Deletion23128226
    esv1351588CNV Deletion17803354
    esv2720968CNV Deletion23290073
    esv2436407CNV Deletion19546169
    esv1007811CNV Deletion20482838
    esv2720967CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for FMNL2:    About MalaCards
    chondrosarcoma    colorectal cancer    hepatocellular carcinoma

    1 disease from the University of Copenhagen DISEASES database for FMNL2:
    Chondrosarcoma

    FMNL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FMNL2
    Human Genome Epidemiology (HuGE) Navigator: FMNL2 (2 documents)

    Export disorders for FMNL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FMNL2 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with FMNL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico. (PubMed id 12684686)1, 2, 9 Katoh M. and Katoh M. (2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PubMed id 19401682)1, 4 Maestrini E....Monaco A.P. (2009)
    4. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2 Nagase T....Ohara O. (2001)
    5. Overexpression of FMNL2 is closely related to metastasis of colorectal cancer. (PubMed id 18665374)1, 9 Zhu X.L....Ding Y.Q. (2008)
    6. Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC. (PubMed id 20101212)1, 9 Kitzing T.M....Grosse R. (2010)
    7. Loci associated with N-glycosylation of human immunogl obulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (2013)
    8. MicroRNA-137, an HMGA1 target, suppresses colorectal c ancer cell invasion and metastasis in mice by directly targeting FMNL2. (PubMed id 23201162)1 Liang L....Ding Y. (2013)
    9. Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
    10. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O....Lill R. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 114793 HGNC: 18267 AceView: FMNL2 Ensembl:ENSG00000157827 euGenes: HUgn114793
    ECgene: FMNL2 H-InvDB: FMNL2

    (According to HUGE)
    About This Section
    HUGE: KIAA1902

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FMNL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FMNL2 gene:
    Search GeneIP for patents involving FMNL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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