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Aliases for FMNL2 Gene

Aliases for FMNL2 Gene

  • Formin Like 2 2 3 5
  • Formin Homology 2 Domain-Containing Protein 2 3 4
  • Formin Homology 2 Domain Containing 2 2 3
  • FHOD2 3 4
  • Formin-Like Protein 2 3
  • Formin-Like 2 2
  • KIAA1902 4

External Ids for FMNL2 Gene

Previous HGNC Symbols for FMNL2 Gene

  • FHOD2

Previous GeneCards Identifiers for FMNL2 Gene

  • GC02U900457
  • GC02P153395
  • GC02P153017
  • GC02P152899
  • GC02P153191
  • GC02P145077

Summaries for FMNL2 Gene

Entrez Gene Summary for FMNL2 Gene

  • This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for FMNL2 Gene

FMNL2 (Formin Like 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Mitotic Prometaphase. GO annotations related to this gene include binding and Rho GTPase binding. An important paralog of this gene is FMNL3.

UniProtKB/Swiss-Prot for FMNL2 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics.

Gene Wiki entry for FMNL2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FMNL2 Gene

Genomics for FMNL2 Gene

Regulatory Elements for FMNL2 Gene

Enhancers for FMNL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G152464 1.4 Ensembl ENCODE dbSUPER 16 +131.8 131806 6.1 FEZF1 RAD21 RARA GLIS2 EGR1 ZSCAN5C SCRT2 FOS RELB IKZF2 FMNL2 ENSG00000270776 NUDCP1
GH02G152462 0.9 FANTOM5 ENCODE dbSUPER 22.8 +127.8 127770 0.3 TGIF2 FMNL2 ARL6IP6 CACNB4 NUDCP1 ENSG00000270776
GH02G152485 1.5 Ensembl ENCODE dbSUPER 10.5 +151.3 151326 2.2 HNRNPUL1 FOXA2 ATF1 MLX ARID4B DMAP1 SLC30A9 SP5 ZHX2 MXD4 FMNL2 ENSG00000270776 NUDCP1
GH02G152452 1.2 FANTOM5 ENCODE dbSUPER 12 +118.5 118476 3.0 SOX5 ZNF263 SOX13 CHD7 ATF2 SMARCA4 POLR2A HOMEZ FMNL2 ARL6IP6 CACNB4 NUDCP1 ENSG00000270776
GH02G152383 0.8 dbSUPER 17.4 +50.1 50050 2.6 SOX13 PKNOX1 ARID4B CEBPG TEAD3 NCOR1 NR2F6 ZNF652 HOMEZ MIXL1 FMNL2 NUDCP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FMNL2 on UCSC Golden Path with GeneCards custom track

Promoters for FMNL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000124712 830 2801 FOXA2 MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for FMNL2 Gene

Chromosome:
2
Start:
152,335,170 bp from pter
End:
152,649,834 bp from pter
Size:
314,665 bases
Orientation:
Plus strand

Genomic View for FMNL2 Gene

Genes around FMNL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FMNL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FMNL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMNL2 Gene

Proteins for FMNL2 Gene

  • Protein details for FMNL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PY5-FMNL2_HUMAN
    Recommended name:
    Formin-like protein 2
    Protein Accession:
    Q96PY5
    Secondary Accessions:
    • B2RZH5
    • Q14CC9
    • Q4ZG52
    • Q8N3E0

    Protein attributes for FMNL2 Gene

    Size:
    1086 amino acids
    Molecular mass:
    123321 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI13879.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=AAI14439.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=AAX88959.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB67795.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FMNL2 Gene

    Alternative splice isoforms for FMNL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FMNL2 Gene

Post-translational modifications for FMNL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FMNL2 Gene

Domains & Families for FMNL2 Gene

Suggested Antigen Peptide Sequences for FMNL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96PY5

UniProtKB/Swiss-Prot:

FMNL2_HUMAN :
  • The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
  • Belongs to the formin homology family.
Domain:
  • The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
Family:
  • Belongs to the formin homology family.
genes like me logo Genes that share domains with FMNL2: view

No data available for Gene Families for FMNL2 Gene

Function for FMNL2 Gene

Molecular function for FMNL2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics.

Gene Ontology (GO) - Molecular Function for FMNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0017048 Rho GTPase binding IEA --
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with FMNL2: view

Phenotypes for FMNL2 Gene

genes like me logo Genes that share phenotypes with FMNL2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FMNL2 Gene

Localization for FMNL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMNL2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FMNL2 gene
Compartment Confidence
cytosol 5
plasma membrane 2
cytoskeleton 2
nucleus 2
golgi apparatus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FMNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FMNL2: view

Pathways & Interactions for FMNL2 Gene

genes like me logo Genes that share pathways with FMNL2: view

Pathways by source for FMNL2 Gene

Gene Ontology (GO) - Biological Process for FMNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IMP,IEA 21834987
GO:0016043 cellular component organization IEA --
GO:0022604 regulation of cell morphogenesis IMP,IEA 21834987
GO:0030036 actin cytoskeleton organization IEA --
GO:0030866 cortical actin cytoskeleton organization IMP 21834987
genes like me logo Genes that share ontologies with FMNL2: view

No data available for SIGNOR curated interactions for FMNL2 Gene

Transcripts for FMNL2 Gene

Unigene Clusters for FMNL2 Gene

Formin-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FMNL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^
SP1: - -
SP2:
SP3:
SP4:
SP5:

ExUns: 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c
SP1: - - -
SP2: -
SP3: - -
SP4:
SP5: - -

Relevant External Links for FMNL2 Gene

GeneLoc Exon Structure for
FMNL2
ECgene alternative splicing isoforms for
FMNL2

Expression for FMNL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FMNL2 Gene

mRNA differential expression in normal tissues according to GTEx for FMNL2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.2).

Protein differential expression in normal tissues from HIPED for FMNL2 Gene

This gene is overexpressed in Spinal cord (29.2) and Frontal cortex (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FMNL2 Gene



Protein tissue co-expression partners for FMNL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FMNL2 Gene:

FMNL2

SOURCE GeneReport for Unigene cluster for FMNL2 Gene:

Hs.654630

Evidence on tissue expression from TISSUES for FMNL2 Gene

  • Nervous system(4.8)
  • Liver(2.5)
  • Skin(2)
genes like me logo Genes that share expression patterns with FMNL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FMNL2 Gene

Orthologs for FMNL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FMNL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FMNL2 34 35
  • 99.27 (n)
cow
(Bos Taurus)
Mammalia FMNL2 34 35
  • 92.09 (n)
oppossum
(Monodelphis domestica)
Mammalia FMNL2 35
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1560248 34
  • 90.4 (n)
mouse
(Mus musculus)
Mammalia Fmnl2 34 16 35
  • 90.16 (n)
dog
(Canis familiaris)
Mammalia FMNL2 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FMNL2 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves FMNL2 34 35
  • 81.61 (n)
lizard
(Anolis carolinensis)
Reptilia FMNL2 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fmnl2 34
  • 78.56 (n)
zebrafish
(Danio rerio)
Actinopterygii fmnl2a 34 35
  • 74.22 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32138 34 35
  • 53.74 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004805 34
  • 51.83 (n)
worm
(Caenorhabditis elegans)
Secernentea frl-1 35
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 58 (a)
OneToMany
Species where no ortholog for FMNL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FMNL2 Gene

ENSEMBL:
Gene Tree for FMNL2 (if available)
TreeFam:
Gene Tree for FMNL2 (if available)

Paralogs for FMNL2 Gene

Paralogs for FMNL2 Gene

(3) SIMAP similar genes for FMNL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FMNL2: view

Variants for FMNL2 Gene

Sequence variations from dbSNP and Humsavar for FMNL2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000004689 -- 152,476,450(+) AGGAT(C/T)TCTTG intron-variant
rs1000005390 -- 152,606,007(+) GGAAC(G/T)TACAA intron-variant
rs1000012199 -- 152,346,026(+) TTTTT(A/T)TTCTT intron-variant
rs1000017496 -- 152,555,161(+) TTGAA(A/G)ACAAC intron-variant
rs1000024772 -- 152,387,408(+) GTTGA(A/G)TACGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FMNL2 Gene

Variant ID Type Subtype PubMed ID
dgv2062n106 CNV deletion 24896259
dgv253e215 CNV deletion 23714750
esv1007811 CNV deletion 20482838
esv1351588 CNV deletion 17803354
esv1998324 CNV deletion 18987734
esv2436407 CNV deletion 19546169
esv2665352 CNV deletion 23128226
esv2671971 CNV deletion 23128226
esv2720967 CNV deletion 23290073
esv2720968 CNV deletion 23290073
esv2720969 CNV deletion 23290073
esv2720970 CNV deletion 23290073
esv2841570 CNV deletion 24192839
esv3338698 CNV insertion 20981092
esv3341551 CNV insertion 20981092
esv3402420 CNV insertion 20981092
esv34659 CNV loss 17911159
esv3592922 CNV loss 21293372
esv3592934 CNV loss 21293372
esv3592935 CNV loss 21293372
esv3592937 CNV loss 21293372
nsv1005012 CNV gain 25217958
nsv1127772 CNV deletion 24896259
nsv2979 CNV insertion 18451855
nsv511817 CNV loss 21212237
nsv513645 OTHER inversion 21212237
nsv7331 OTHER inversion 18451855
nsv819333 CNV loss 19587683
nsv821758 CNV loss 20364138
nsv834419 CNV gain+loss 17160897
nsv834420 CNV loss 17160897
nsv834421 CNV loss 17160897
nsv979137 CNV duplication 23825009

Variation tolerance for FMNL2 Gene

Residual Variation Intolerance Score: 14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FMNL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FMNL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FMNL2 Gene

Disorders for FMNL2 Gene

Relevant External Links for FMNL2

Genetic Association Database (GAD)
FMNL2
Human Genome Epidemiology (HuGE) Navigator
FMNL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FMNL2

No disorders were found for FMNL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FMNL2 Gene

Publications for FMNL2 Gene

  1. Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico. (PMID: 12684686) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 4 22 64
  2. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PMID: 21834987) Bai S.W. … Ridley A.J. (BMC Biol. 2011) 3 4 64
  3. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PMID: 19401682) Maestrini E. … Monaco A.P. (Mol. Psychiatry 2010) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC. (PMID: 20101212) Kitzing T.M. … Grosse R. (Oncogene 2010) 3 22 64

Products for FMNL2 Gene

Sources for FMNL2 Gene

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