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Aliases for FMNL2 Gene

Aliases for FMNL2 Gene

  • Formin Like 2 2 3 5
  • Formin Homology 2 Domain-Containing Protein 2 3 4
  • Formin Homology 2 Domain Containing 2 2 3
  • Formin-Like 2 2 3
  • FHOD2 3 4
  • KIAA1902 4

External Ids for FMNL2 Gene

Previous HGNC Symbols for FMNL2 Gene

  • FHOD2

Previous GeneCards Identifiers for FMNL2 Gene

  • GC02U900457
  • GC02P153395
  • GC02P153017
  • GC02P152899
  • GC02P153191
  • GC02P145077

Summaries for FMNL2 Gene

Entrez Gene Summary for FMNL2 Gene

  • This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for FMNL2 Gene

FMNL2 (Formin Like 2) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and Mitotic Prometaphase. GO annotations related to this gene include binding and Rho GTPase binding. An important paralog of this gene is DIAPH3.

UniProtKB/Swiss-Prot for FMNL2 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics.

Gene Wiki entry for FMNL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FMNL2 Gene

Genomics for FMNL2 Gene

Regulatory Elements for FMNL2 Gene

Enhancers for FMNL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FMNL2 on UCSC Golden Path with GeneCards custom track

Promoters for FMNL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FMNL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FMNL2 Gene

Chromosome:
2
Start:
152,335,170 bp from pter
End:
152,649,834 bp from pter
Size:
314,665 bases
Orientation:
Plus strand

Genomic View for FMNL2 Gene

Genes around FMNL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FMNL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FMNL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMNL2 Gene

Proteins for FMNL2 Gene

  • Protein details for FMNL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PY5-FMNL2_HUMAN
    Recommended name:
    Formin-like protein 2
    Protein Accession:
    Q96PY5
    Secondary Accessions:
    • B2RZH5
    • Q14CC9
    • Q4ZG52
    • Q8N3E0

    Protein attributes for FMNL2 Gene

    Size:
    1086 amino acids
    Molecular mass:
    123321 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI13879.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=AAI14439.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=AAX88959.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB67795.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FMNL2 Gene

    Alternative splice isoforms for FMNL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FMNL2 Gene

Proteomics data for FMNL2 Gene at MOPED

Post-translational modifications for FMNL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FMNL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FMNL2 Gene

Domains & Families for FMNL2 Gene

Suggested Antigen Peptide Sequences for FMNL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96PY5

UniProtKB/Swiss-Prot:

FMNL2_HUMAN :
  • The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
  • Belongs to the formin homology family.
Domain:
  • The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
  • Contains 1 DAD (diaphanous autoregulatory) domain.
  • Contains 1 FH2 (formin homology 2) domain.
  • Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
Family:
  • Belongs to the formin homology family.
genes like me logo Genes that share domains with FMNL2: view

No data available for Gene Families for FMNL2 Gene

Function for FMNL2 Gene

Molecular function for FMNL2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics.

Phenotypes for FMNL2 Gene

genes like me logo Genes that share phenotypes with FMNL2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FMNL2 Gene

Localization for FMNL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMNL2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FMNL2 Gene COMPARTMENTS Subcellular localization image for FMNL2 gene
Compartment Confidence
cytosol 5
cytoskeleton 2
golgi apparatus 2
nucleus 2
plasma membrane 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for FMNL2 Gene

Pathways & Interactions for FMNL2 Gene

genes like me logo Genes that share pathways with FMNL2: view

Pathways by source for FMNL2 Gene

Gene Ontology (GO) - Biological Process for FMNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0016043 cellular component organization IEA --
genes like me logo Genes that share ontologies with FMNL2: view

No data available for SIGNOR curated interactions for FMNL2 Gene

Drugs & Compounds for FMNL2 Gene

No Compound Related Data Available

Transcripts for FMNL2 Gene

Unigene Clusters for FMNL2 Gene

Formin-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FMNL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^
SP1: - -
SP2:
SP3:
SP4:
SP5:

ExUns: 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c
SP1: - - -
SP2: -
SP3: - -
SP4:
SP5: - -

Relevant External Links for FMNL2 Gene

GeneLoc Exon Structure for
FMNL2
ECgene alternative splicing isoforms for
FMNL2

Expression for FMNL2 Gene

mRNA expression in normal human tissues for FMNL2 Gene

mRNA differential expression in normal tissues according to GTEx for FMNL2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.2).

Protein differential expression in normal tissues from HIPED for FMNL2 Gene

This gene is overexpressed in Spinal cord (29.2) and Frontal cortex (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FMNL2 Gene



SOURCE GeneReport for Unigene cluster for FMNL2 Gene Hs.654630

genes like me logo Genes that share expression patterns with FMNL2: view

Protein tissue co-expression partners for FMNL2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FMNL2 Gene

Orthologs for FMNL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FMNL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FMNL2 35
  • 92.09 (n)
  • 97.53 (a)
FMNL2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fmnl2 35
  • 90.16 (n)
  • 96.12 (a)
Fmnl2 16
Fmnl2 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FMNL2 35
  • 99.27 (n)
  • 99.73 (a)
FMNL2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1560248 35
  • 90.4 (n)
  • 97.13 (a)
dog
(Canis familiaris)
Mammalia FMNL2 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FMNL2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FMNL2 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves FMNL2 35
  • 81.61 (n)
  • 93.16 (a)
FMNL2 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FMNL2 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fmnl2 35
  • 78.56 (n)
  • 89.14 (a)
zebrafish
(Danio rerio)
Actinopterygii fmnl2a 35
  • 74.22 (n)
  • 83.94 (a)
fmnl2a 36
  • 82 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004805 35
  • 51.83 (n)
  • 44.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32138 35
  • 53.74 (n)
  • 49.47 (a)
CG32138 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea frl-1 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToMany
Species with no ortholog for FMNL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FMNL2 Gene

ENSEMBL:
Gene Tree for FMNL2 (if available)
TreeFam:
Gene Tree for FMNL2 (if available)

Paralogs for FMNL2 Gene

Paralogs for FMNL2 Gene

(3) SIMAP similar genes for FMNL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FMNL2: view

Variants for FMNL2 Gene

Sequence variations from dbSNP and Humsavar for FMNL2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs34119671 - 152,611,598(-) CCAAG(C/T)ATTCG nc-transcript-variant, reference, missense
rs11897929 - 152,619,042(+) GTCCA(C/T)GGGGT nc-transcript-variant, reference, missense
rs727326 -- 152,608,066(-) AGATT(A/G)AGATT intron-variant
rs727327 -- 152,607,985(-) GAACC(A/G)CATGT intron-variant
rs734541 -- 152,588,795(-) CACTA(C/T)GAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FMNL2 Gene

Variant ID Type Subtype PubMed ID
esv34659 CNV Loss 17911159
nsv7331 OTHER Inversion 18451855
nsv834419 CNV Gain+Loss 17160897
esv2436407 CNV Deletion 19546169
esv2720967 CNV Deletion 23290073
esv1998324 CNV Deletion 18987734
esv2671971 CNV Deletion 23128226
esv1007811 CNV Deletion 20482838
esv2720968 CNV Deletion 23290073
esv2720969 CNV Deletion 23290073
esv1351588 CNV Deletion 17803354
esv273110 CNV Insertion 20981092
esv271267 CNV Insertion 20981092
nsv875291 CNV Loss 21882294
nsv875292 CNV Loss 21882294
esv2720970 CNV Deletion 23290073
nsv2979 CNV Insertion 18451855
nsv834420 CNV Loss 17160897
esv270266 CNV Insertion 20981092
nsv513645 OTHER Inversion 21212237
nsv511817 CNV Loss 21212237
nsv819333 CNV Loss 19587683
nsv821758 CNV Loss 20364138
esv2665352 CNV Deletion 23128226
nsv834421 CNV Loss 17160897

Variation tolerance for FMNL2 Gene

Residual Variation Intolerance Score: 14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FMNL2 Gene

Disorders for FMNL2 Gene

Relevant External Links for FMNL2

Genetic Association Database (GAD)
FMNL2
Human Genome Epidemiology (HuGE) Navigator
FMNL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FMNL2

No disorders were found for FMNL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FMNL2 Gene

Publications for FMNL2 Gene

  1. Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico. (PMID: 12684686) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 4 23 67
  2. Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC. (PMID: 20101212) Kitzing T.M. … Grosse R. (Oncogene 2010) 3 23
  3. Overexpression of FMNL2 is closely related to metastasis of colorectal cancer. (PMID: 18665374) Zhu X.L. … Ding Y.Q. (Int J Colorectal Dis 2008) 3 23
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. Junctional actin assembly is mediated by Formin-like 2 downstream of Rac1. (PMID: 25963818) Grikscheit K. … Grosse R. (J. Cell Biol. 2015) 3

Products for FMNL2 Gene

Sources for FMNL2 Gene

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