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FMNL2 Gene

protein-coding   GIFtS: 55
GCID: GC02P153191

Formin-Like 2

(Previous name: formin homology 2 domain containing 2)
(Previous symbol: FHOD2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Formin-Like 21 2
FHOD21 2 3
Formin Homology 2 Domain Containing 21 2
Formin Homology 2 Domain-Containing Protein 22 3
Formin-Like Protein 22
KIAA19023

External Ids:    HGNC: 182671   Entrez Gene: 1147932   Ensembl: ENSG000001578277   UniProtKB: Q96PY53   

Export aliases for FMNL2 gene to outside databases

Previous GC identifers: GC02U900457 GC02P153395 GC02P153017 GC02P152899 GC02P145077


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FMNL2 Gene:
This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis,
cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been
described but their full-length nature has yet to be determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for FMNL2 Gene:
FMNL2 (formin-like 2) is a protein-coding gene. GO annotations related to this gene include Rho GTPase binding and actin binding. An important paralog of this gene is DAAM1.

UniProtKB/Swiss-Prot: FMNL2_HUMAN, Q96PY5
Function: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the
cortical actin filament dynamics

Gene Wiki entry for FMNL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FMNL2 gene promoter:
         AML1a   p53   Pax-6   HNF-3beta   POU3F2   FOXL1   AREB6   S8   Zic1   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFMNL2 promoter sequence
   Search Chromatin IP Primers for FMNL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FMNL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q23.3   Ensembl cytogenetic band:  2q23.3   HGNC cytogenetic band: 2q23.3

FMNL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FMNL2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P153191:  view genomic region     (about GC identifiers)

Start:
153,191,751 bp from pter      End:
153,506,348 bp from pter
Size:
314,598 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FMNL2_HUMAN, Q96PY5 (See protein sequence)
Recommended Name: Formin-like protein 2  
Size: 1086 amino acids; 123321 Da
Sequence caution: Sequence=AAI13879.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Sequence=AAI14439.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=AAX88959.1; Type=Erroneous
gene model prediction; Sequence=BAB67795.1; Type=Erroneous initiation;
Secondary accessions: B2RZH5 Q14CC9 Q4ZG52 Q8N3E0
Alternative splicing: 2 isoforms:  Q96PY5-1   Q96PY5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FMNL2: NX_Q96PY5

Explore proteomics data for FMNL2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FMNL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_443137.2  
    ENSEMBL proteins: 
     ENSP00000288670   ENSP00000418959  

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    antibodies-online proteins for FMNL2 (2 products) 

     
    antibodies-online peptides for FMNL2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 8):
     IPR010473 GTPase-bd
     IPR010472 FH3_dom
     IPR015425 FH2_Formin
     IPR014767 Diaphanous_autoregulatory
     IPR014768 GTPase-bd/formin_homology_3

    Graphical View of Domain Structure for InterPro Entry Q96PY5

    ProtoNet protein and cluster: Q96PY5

    3 Blocks protein domains:
    IPB001950 Translation initiation factor SUI1
    IPB003104 Actin-binding FH2
    IPB010472 Diaphanous FH3


    UniProtKB/Swiss-Prot: FMNL2_HUMAN, Q96PY5
    Domain: The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This
    autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2
    domain to then nucleate and elongate nonbranched actin filaments (By similarity)
    Similarity: Belongs to the formin homology family
    Similarity: Contains 1 DAD (diaphanous autoregulatory) domain
    Similarity: Contains 1 FH2 (formin homology 2) domain
    Similarity: Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain


    Find genes that share domains with FMNL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FMNL2_HUMAN, Q96PY5
    Function: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the
    cortical actin filament dynamics

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005488binding ----
    GO:0017048Rho GTPase binding IEA--
         
    Find genes that share ontologies with FMNL2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FMNL2

    miRNA
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    miRTarBase miRNAs that target FMNL2:
    hsa-mir-1229-3p (MIRT036331), hsa-mir-124-3p (MIRT022700), hsa-mir-93-5p (MIRT027997), hsa-mir-155-5p (MIRT001547), hsa-mir-1 (MIRT023863)

    Block miRNA regulation of human, mouse, rat FMNL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FMNL2 (see all 45):
    hsa-miR-548j hsa-miR-3607-3p hsa-miR-300 hsa-miR-3653 hsa-miR-508-3p hsa-miR-124 hsa-miR-548a-5p hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidFMNL2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FMNL2_HUMAN, Q96PY5: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    cytoskeleton1
    golgi apparatus1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with FMNL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FMNL2
    Interactions:

        Search GeneGlobe Interaction Network for FMNL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FMNL2 (Q96PY52, 3 ENSP000002886704) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF40AO754002, 3MINT-61867 I2D: score=3 
    CDC42P609533, ENSP000003144584I2D: score=3 STRING: ENSP00000314458
    SPRY2ENSP000003663064STRING: ENSP00000366306
    LAPTM4AENSP000001750914STRING: ENSP00000175091
    TMEM184AENSP000002974774STRING: ENSP00000297477
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization IMP--
    GO:0016043cellular component organization ----
    GO:0022604regulation of cell morphogenesis IMP--
    GO:0030036actin cytoskeleton organization ----
    GO:0030866cortical actin cytoskeleton organization IMP--

    Find genes that share ontologies with FMNL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for FMNL2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FMNL2 gene (4 alternative transcripts): 
    NM_052905.3  NM_001004417.1  NM_001004421.1  NM_001004422.1  

    Unigene Cluster for FMNL2:

    Formin-like 2
    Hs.654630  [show with all ESTs]
    Unigene Representative Sequence: NM_052905
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000288670(uc002tye.3 uc002tyf.3) ENST00000492942 ENST00000475377(uc010fob.3)
    ENST00000497192
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FMNL2 (see all 45):
    hsa-miR-548j hsa-miR-3607-3p hsa-miR-300 hsa-miR-3653 hsa-miR-508-3p hsa-miR-124 hsa-miR-548a-5p hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidFMNL2 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat FMNL2

    Additional mRNA sequence: 

    AB067489.1 AK094865.1 AK131316.1 AL834396.1 BC014343.1 BC036492.2 BC113878.1 BC114438.1 
    BC126995.1 BC127621.1 BC128084.1 BC167159.1 

    11 DOTS entries:

    DT.99961199  DT.91966515  DT.95275492  DT.100782348  DT.100011998  DT.120999787  DT.95275494  DT.120999784 
    DT.40201963  DT.91920142  DT.40110934 

    Selected AceView cDNA sequences (see all 147):

    AW589866 BU631977 AA421752 AA605038 BF512402 AI370547 AI867578 AI656379 
    BM785610 NM_052905 AK131316 AA449419 NM_001004421 AA022985 AI984743 CA389003 
    BM768089 BM682552 NM_001004417 AI923431 AK094865 BU784967 BI766246 BM726119 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FMNL2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^
    SP1:                                      -                       -                                                                                             
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c
    SP1:                    -     -     -                     
    SP2:                    -                                 
    SP3:                          -     -                     
    SP4:                                                      
    SP5:                    -           -                     


    ECgene alternative splicing isoforms for FMNL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FMNL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCATATGAGC
    FMNL2 Expression
    About this image


    FMNL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Common Dendritic Cell Precursors Hematopoietic Bone Marrow
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    FMNL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FMNL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654630
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMNL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FMNL2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fmnl21 , 5 formin-like 21, 5 90.16(n)1
    96.12(a)1
      2 (30.69 cM)5
    714091  NM_172409.21  NP_765997.21 
     528578605 
    chicken
    (Gallus gallus)
    Aves FMNL21 formin-like 2 81.61(n)
    93.16(a)
      771739  XM_001234980.3  XP_001234981.3 
    lizard
    (Anolis carolinensis)
    Reptilia FMNL26
    formin-like 2
    87(a)
    1 ↔ 1
    GL343296.1(1051750-1282751)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fmnl21 formin-like 2 78.56(n)
    89.14(a)
      100491499  XM_004917684.1  XP_004917741.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fmnl2a1 formin-like 2a 74.22(n)
    83.94(a)
      100006456  XM_005167947.1  XP_005168004.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG321381 CG32138 53.74(n)
    49.47(a)
      39561  NM_168575.3  NP_729954.2 
    worm
    (Caenorhabditis elegans)
    Secernentea frl-16
    Protein FRL-1 (frl-1) mRNA, complete cds
    33(a)
    1 → many
    III(2134475-2151554) WBGene00021698


    ENSEMBL Gene Tree for FMNL2 (if available)
    TreeFam Gene Tree for FMNL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FMNL2 gene
    DAAM12  DIAPH12  FMNL32  FHDC12  FMNL12  DAAM22  INF22  GRID2IP2  
    FMN12  DIAPH22  FMN22  DIAPH32  
    3 SIMAP similar genes for FMNL2 using alignment to 3 protein entries:     FMNL2_HUMAN (see all proteins):
    DKFZp762B245    FMNL3    FMNL1

    Find genes that share paralogs with FMNL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FMNL2 (see all 6376)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs722815631,2
    C--145096991(+) TCTGT-/TTGA  
            
    TTAAC
    1 -- int10--------
    rs347356741,2
    C--145385768(+) TGTCT-/GTAATCC 1 -- int11Minor allele frequency- GT:0.00NA 2
    rs359533681,2
    C,F--153189893(+) AAGACG/ATAAGG 1 -- us2k19Minor allele frequency- A:0.34WA NA CSA EA 370
    rs1444304241,2
    --153189899(+) TAAGGA/GGAGAA 1 -- us2k10--------
    rs46641001,2
    C,F,A,H--153190223(+) CTTTGG/ATACAA 1 -- us2k1 tfbs322Minor allele frequency- A:0.46NS EA NA WA CSA 2350
    rs1451185571,2
    C--153190265(+) CAGAAC/TTTTAA 1 -- us2k10--------
    rs1484120021,2
    --153190277(+) TTGAAA/TTTATT 1 -- us2k10--------
    rs621795251,2
    F--153190340(+) ATGTAC/TTTGTG 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1450419131,2
    --153190361(+) TCATAC/TGCTTT 1 -- us2k10--------
    rs1929437431,2
    --153190408(+) TGGGCA/GTCTAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FMNL2 (153191751 - 153441751 bp, first 250kb of FMNL2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FMNL2 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2720970CNV Deletion23290073
    esv2665352CNV Deletion23128226
    esv2720969CNV Deletion23290073
    esv1998324CNV Deletion18987734
    esv2671971CNV Deletion23128226
    esv1351588CNV Deletion17803354
    esv2720968CNV Deletion23290073
    esv2436407CNV Deletion19546169
    esv1007811CNV Deletion20482838
    esv2720967CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    1 disease from the University of Copenhagen DISEASES database for FMNL2:
    Chondrosarcoma

    Find genes that share disorders with FMNL2           About GenesLikeMe

    Genetic Association Database (GAD): FMNL2
    Human Genome Epidemiology (HuGE) Navigator: FMNL2 (2 documents)

    Export disorders for FMNL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FMNL2 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with FMNL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico. (PubMed id 12684686)1, 2, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PubMed id 19401682)1, 4 Maestrini E....Monaco A.P. (Mol. Psychiatry 2010)
    4. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    5. Overexpression of FMNL2 is closely related to metastasis of colorectal cancer. (PubMed id 18665374)1, 9 Zhu X.L....Ding Y.Q. (Int J Colorectal Dis 2008)
    6. Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC. (PubMed id 20101212)1, 9 Kitzing T.M....Grosse R. (Oncogene 2010)
    7. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    8. MicroRNA-137, an HMGA1 target, suppresses colorectal cancer cell invasion and metastasis in mice by directly targeting FMNL2. (PubMed id 23201162)1 Liang L....Ding Y. (Gastroenterology 2013)
    9. Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (PLoS ONE 2012)
    10. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O.... Lill R. (Science 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 114793 HGNC: 18267 AceView: FMNL2 Ensembl:ENSG00000157827 euGenes: HUgn114793
    ECgene: FMNL2 H-InvDB: FMNL2

    (According to HUGE)
    About This Section

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    HUGE: KIAA1902

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FMNL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FMNL2 gene:
    Search GeneIP for patents involving FMNL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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