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Aliases for FMNL2 Gene

Aliases for FMNL2 Gene

  • Formin-Like 2 2 3
  • Formin Homology 2 Domain-Containing Protein 2 3 4
  • Formin Homology 2 Domain Containing 2 2 3
  • FHOD2 3 4
  • Formin-Like Protein 2 3
  • KIAA1902 4

External Ids for FMNL2 Gene

Previous Symbols for FMNL2 Gene

  • FHOD2

Summaries for FMNL2 Gene

Entrez Gene Summary for FMNL2 Gene

  • This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for FMNL2 Gene

FMNL2 (Formin-Like 2) is a Protein Coding gene. GO annotations related to this gene include actin binding and Rho GTPase binding. An important paralog of this gene is FMN2.

UniProtKB/Swiss-Prot for FMNL2 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics.

Gene Wiki entry for FMNL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FMNL2 Gene

Genomics for FMNL2 Gene

Genomic Location for FMNL2 Gene

Start:
152,335,170 bp from pter
End:
152,649,834 bp from pter
Size:
314,665 bases
Orientation:
Plus strand

Genomic View for FMNL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FMNL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMNL2 Gene

Regulatory Elements for FMNL2 Gene

Proteins for FMNL2 Gene

  • Protein details for FMNL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PY5-FMNL2_HUMAN
    Recommended name:
    Formin-like protein 2
    Protein Accession:
    Q96PY5
    Secondary Accessions:
    • B2RZH5
    • Q14CC9
    • Q4ZG52
    • Q8N3E0

    Protein attributes for FMNL2 Gene

    Size:
    1086 amino acids
    Molecular mass:
    123321 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI13879.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=AAI14439.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=AAX88959.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB67795.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FMNL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FMNL2 Gene

Proteomics data for FMNL2 Gene at MOPED

Post-translational modifications for FMNL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FMNL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FMNL2 Gene

Domains for FMNL2 Gene

UniProtKB/Swiss-Prot:

FMNL2_HUMAN
Domain:
  • The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).:
    • Q96PY5
  • Contains 1 DAD (diaphanous autoregulatory) domain.:
    • Q96PY5
  • Contains 1 FH2 (formin homology 2) domain.:
    • Q96PY5
  • Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.:
    • Q96PY5
Family:
  • Belongs to the formin homology family.:
    • Q96PY5
genes like me logo Genes that share domains with FMNL2: view

No data available for Gene Families for FMNL2 Gene

Function for FMNL2 Gene

Molecular function for FMNL2 Gene

UniProtKB/Swiss-Prot Function: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics.

Gene Ontology (GO) - Molecular Function for FMNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005488 binding --
GO:0017048 Rho GTPase binding IEA --
genes like me logo Genes that share ontologies with FMNL2: view

miRNA for FMNL2 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FMNL2 Gene

Localization for FMNL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMNL2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FMNL2 Gene COMPARTMENTS Subcellular localization image for FMNL2 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FMNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FMNL2: view

Pathways for FMNL2 Gene

SuperPathways for FMNL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FMNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IMP 21834987
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0016043 cellular component organization --
GO:0022604 regulation of cell morphogenesis IMP 21834987
GO:0030036 actin cytoskeleton organization --
genes like me logo Genes that share ontologies with FMNL2: view

No data available for Pathways by source for FMNL2 Gene

Transcripts for FMNL2 Gene

Unigene Clusters for FMNL2 Gene

Formin-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FMNL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^
SP1: - -
SP2:
SP3:
SP4:
SP5:

ExUns: 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c
SP1: - - -
SP2: -
SP3: - -
SP4:
SP5: - -

Relevant External Links for FMNL2 Gene

GeneLoc Exon Structure for
FMNL2
ECgene alternative splicing isoforms for
FMNL2

Expression for FMNL2 Gene

mRNA expression in normal human tissues for FMNL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FMNL2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FMNL2 Gene

SOURCE GeneReport for Unigene cluster for FMNL2 Gene Hs.654630

genes like me logo Genes that share expressions with FMNL2: view

Orthologs for FMNL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FMNL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FMNL2 36
  • 99.27 (n)
  • 99.73 (a)
FMNL2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FMNL2 36
  • 92.09 (n)
  • 97.53 (a)
FMNL2 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FMNL2 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fmnl2 36
  • 90.16 (n)
  • 96.12 (a)
Fmnl2 16
Fmnl2 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FMNL2 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FMNL2 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1560248 36
  • 90.4 (n)
  • 97.13 (a)
chicken
(Gallus gallus)
Aves FMNL2 36
  • 81.61 (n)
  • 93.16 (a)
FMNL2 37
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FMNL2 37
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fmnl2 36
  • 78.56 (n)
  • 89.14 (a)
zebrafish
(Danio rerio)
Actinopterygii fmnl2a 36
  • 74.22 (n)
  • 83.94 (a)
fmnl2a 37
  • 82 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004805 36
  • 51.83 (n)
  • 44.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32138 36
  • 53.74 (n)
  • 49.47 (a)
CG32138 37
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea frl-1 37
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 58 (a)
OneToMany
Species with no ortholog for FMNL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FMNL2 Gene

ENSEMBL:
Gene Tree for FMNL2 (if available)
TreeFam:
Gene Tree for FMNL2 (if available)

Paralogs for FMNL2 Gene

Selected SIMAP similar genes for FMNL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FMNL2: view

Variants for FMNL2 Gene

Sequence variations from dbSNP and Humsavar for FMNL2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2463 -- 152,648,862(+) AGTTT(C/T)TCATG utr-variant-3-prime
rs715046 -- 152,646,289(-) GTAGT(A/G)GTGAT intron-variant
rs715047 -- 152,646,214(-) GCTGG(A/G)CTACA intron-variant
rs727326 -- 152,608,066(-) AGATT(A/G)AGATT intron-variant
rs727327 -- 152,607,985(-) GAACC(A/G)CATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FMNL2 Gene

Variant ID Type Subtype PubMed ID
esv34659 CNV Loss 17911159
nsv7331 OTHER Inversion 18451855
nsv834419 CNV Gain+Loss 17160897
esv2436407 CNV Deletion 19546169
esv2720967 CNV Deletion 23290073
esv1998324 CNV Deletion 18987734
esv2671971 CNV Deletion 23128226
esv1007811 CNV Deletion 20482838
esv2720968 CNV Deletion 23290073
esv2720969 CNV Deletion 23290073
esv1351588 CNV Deletion 17803354
esv273110 CNV Insertion 20981092
esv271267 CNV Insertion 20981092
nsv875291 CNV Loss 21882294
nsv875292 CNV Loss 21882294
esv2720970 CNV Deletion 23290073
nsv2979 CNV Insertion 18451855
nsv834420 CNV Loss 17160897
esv270266 CNV Insertion 20981092
nsv513645 OTHER Inversion 21212237
nsv511817 CNV Loss 21212237
nsv819333 CNV Loss 19587683
nsv821758 CNV Loss 20364138
esv2665352 CNV Deletion 23128226
nsv834421 CNV Loss 17160897

Relevant External Links for FMNL2 Gene

HapMap Linkage Disequilibrium report
FMNL2

Disorders for FMNL2 Gene

(1) University of Copenhagen DISEASES for FMNL2 Gene

Relevant External Links for FMNL2

Genetic Association Database (GAD)
FMNL2
Human Genome Epidemiology (HuGE) Navigator
FMNL2
genes like me logo Genes that share disorders with FMNL2: view

No data available for UniProtKB/Swiss-Prot for FMNL2 Gene

Publications for FMNL2 Gene

  1. Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico. (PMID: 12684686) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 3 4 23
  2. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PMID: 19401682) Maestrini E. … Monaco A.P. (Mol. Psychiatry 2010) 3 49
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Overexpression of FMNL2 is closely related to metastasis of colorectal cancer. (PMID: 18665374) Zhu X.L. … Ding Y.Q. (Int J Colorectal Dis 2008) 3 23
  5. Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC. (PMID: 20101212) Kitzing T.M. … Grosse R. (Oncogene 2010) 3 23

Products for FMNL2 Gene

Sources for FMNL2 Gene

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