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FMNL1 Gene

protein-coding   GIFtS: 54
GCID: GC17P043299

Formin-Like 1

(Previous name: formin-like)
(Previous symbols: C17orf1B, FMNL)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Formin-Like 11 2     CLL-Associated Antigen KW-132 3
C17orf1B1 2 3 5     formin-like1
FMNL1 2 3 5     FHOD42
Leukocyte Formin2 3     KW-132
C17orf12 3     Formin-Like Protein 12

External Ids:    HGNC: 12121   Entrez Gene: 7522   Ensembl: ENSG000001849227   OMIM: 6046565   UniProtKB: O954663   
ORGUL members:         

Export aliases for FMNL1 gene to outside databases

Previous GC identifers: GC17P043774 GC17P040656 GC17P039060


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FMNL1 Gene:
This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis,
cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has
not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for FMNL1 Gene:
FMNL1 (formin-like 1) is a protein-coding gene. GO annotations related to this gene include actin filament binding and GTPase activating protein binding. An important paralog of this gene is DAAM1.

UniProtKB/Swiss-Prot: FMNL_HUMAN, O95466
Function: May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a
role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament
dynamics and cell shape

Gene Wiki entry for FMNL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FMNL1 gene promoter:
         c-Fos   ISGF-3   AP-1   MAZR   JunB   Fra-1   FosB   JunD   HSF2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFMNL1 promoter sequence
   Search Chromatin IP Primers for FMNL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FMNL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

FMNL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FMNL1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P043299:  view genomic region     (about GC identifiers)

Start:
43,298,811 bp from pter      End:
43,324,687 bp from pter
Size:
25,877 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FMNL_HUMAN, O95466 (See protein sequence)
Recommended Name: Formin-like protein 1  
Size: 1100 amino acids; 121854 Da
Subunit: Interacts with RAC1, PFN1 and PFN2 (By similarity). Interacts (activated by RAC1) with SRGAP2 (via SH3
domain); regulates the actin filament severing activity of FMNL1
Sequence caution: Sequence=AAH21906.1; Type=Erroneous initiation; Sequence=CAA07870.1; Type=Erroneous initiation;
Secondary accessions: D2DGW2 Q6DKG5 Q6IBP3 Q86UH1 Q8N671 Q8TDH1 Q96H10
Alternative splicing: 3 isoforms:  O95466-1   O95466-2   O95466-3   (Due to intron retention. Constitutively activated form, probably due to alterations in the DAD domain)

Explore the universe of human proteins at neXtProt for FMNL1: NX_O95466

Explore proteomics data for FMNL1 at MOPED

Post-translational modifications: 

  • Myristoylation mediates membrane localization and blebbing1
  • Ubiquitination2 at Lys111
  • Modification sites at PhosphoSitePlus

  • See FMNL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005883.2  
    ENSEMBL proteins: 
     ENSP00000329219   ENSP00000465474   ENSP00000465137   ENSP00000466711   ENSP00000468301  
     ENSP00000327442  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR010473 GTPase-bd
     IPR010472 FH3_dom
     IPR015425 FH2_Formin
     IPR014767 Diaphanous_autoregulatory
     IPR014768 GTPase-bd/formin_homology_3

    Graphical View of Domain Structure for InterPro Entry O95466

    ProtoNet protein and cluster: O95466

    2 Blocks protein domains:
    IPB003104 Actin-binding FH2
    IPB010472 Diaphanous FH3


    UniProtKB/Swiss-Prot: FMNL_HUMAN, O95466
    Domain: The DAD domain regulates activation via by an autoinhibitory interaction with the N-terminus. This
    autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2
    domain to then nucleate and elongate nonbranched actin filaments (By similarity)
    Similarity: Belongs to the formin homology family
    Similarity: Contains 1 DAD (diaphanous autoregulatory) domain
    Similarity: Contains 1 FH2 (formin homology 2) domain
    Similarity: Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain


    Find genes that share domains with FMNL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FMNL_HUMAN, O95466
    Function: May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a
    role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament
    dynamics and cell shape

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003779actin binding ----
    GO:0005488binding ----
    GO:0005515protein binding IPI--
    GO:0005522profilin binding IEA--
         
    Find genes that share ontologies with FMNL1           About GenesLikeMe


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidFMNL1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FMNL_HUMAN, O95466: Cytoplasm (By similarity). Cell membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome (By
    similarity). Note=Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane
    upon activation by RAC1 (By similarity)
    FMNL_HUMAN, O95466: Isoform 3: Cytoplasm, cell cortex. Cell projection, bleb. Note=Colocalized with F-actin in
    bleb protrusions
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    cytoskeleton2
    nucleus2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol ISS--
    GO:0005886plasma membrane ISS--
    GO:0005938cell cortex IEA--
    GO:0032059bleb IEA--
    GO:0045335phagocytic vesicle ISS--

    Find genes that share ontologies with FMNL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FMNL1
    Interactions:

        Search GeneGlobe Interaction Network for FMNL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FMNL1 (O954661, 2, 3 ENSP000003292194) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRCC6P129562, 3, ENSP000003522574MINT-63311 I2D: score=5 STRING: ENSP00000352257
    GAS7O608612, 3, ENSP000003226084MINT-72916 I2D: score=3 STRING: ENSP00000322608
    PRPF40AO754002, 3MINT-61850 I2D: score=5 
    PFN1P077373, ENSP000002256554I2D: score=3 STRING: ENSP00000225655
    PFN2P350803, ENSP000002399404I2D: score=1 STRING: ENSP00000239940
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006929substrate-dependent cell migration IEA--
    GO:0007010cytoskeleton organization ----
    GO:0008360regulation of cell shape IMP--
    GO:0009987cellular process ----
    GO:0016043cellular component organization ----

    Find genes that share ontologies with FMNL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FMNL1 (FMNL)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FMNL1 gene: 
    NM_005892.3  

    Unigene Cluster for FMNL1:

    Formin-like 1
    Hs.100217  [show with all ESTs]
    Unigene Representative Sequence: AK131091
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592415 ENST00000331495(uc002iin.3 uc021tyj.1) ENST00000585852
    ENST00000592006 ENST00000592527 ENST00000587856 ENST00000591434 ENST00000587489
    ENST00000586643 ENST00000589911 ENST00000586092 ENST00000328118(uc002iio.3 uc002iip.1 uc002iiq.3 uc010dag.3)

    miRNA
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    hsa-miR-105* hsa-miR-3163 hsa-miR-218-1* hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidFMNL1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat FMNL1

    Additional mRNA sequence: 

    AF432213.1 AJ008112.1 AJ008113.1 AJ008114.1 AJ008115.1 AJ008116.1 AJ008117.1 AJ008118.1 
    AJ008119.1 AJ008120.1 AJ008121.1 AJ008122.1 AJ008123.1 AJ008124.1 AJ008126.1 AJ008127.1 
    AJ008128.1 AJ008129.1 AJ008130.1 AJ008131.1 AJ008132.1 AJ008133.1 AK131091.1 AY278319.1 
    BC001710.1 BC009000.2 BC021906.1 BC042925.1 BC064572.1 BC073988.1 CR456759.1 FJ534522.1 

    23 DOTS entries:

    DT.305475  DT.95294122  DT.97844663  DT.96086455  DT.99951976  DT.100718200  DT.100839865  DT.120945533 
    DT.75139817  DT.120945560  DT.99953217  DT.75188035  DT.95294135  DT.120945631  DT.91749549  DT.97815418 
    DT.100820826  DT.97801671  DT.91785298  DT.95070943  DT.99965614  DT.120945688  DT.97813760 

    Selected AceView cDNA sequences (see all 213):

    BU148461 AJ008125 CA427251 BU529060 AJ008133 BU195430 BI907951 BM726985 
    AA381887 BG744467 BM917028 AJ008117 BQ878623 AJ008114 AW440875 BU617825 
    AJ008118 CA419185 BI028593 BU616265 BU186638 BQ054225 CD369856 AJ008124 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FMNL1 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^
    SP1:                                                                                                                                                            
    SP2:                                                        -           -                                         -                                             
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                              -                                             

    ExUns: 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b · 23c ^ 24 ^ 25 ^ 26a · 26b ^ 27
    SP1:                                                                                -         
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for FMNL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FMNL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCTTATTT
    FMNL1 Expression
    About this image

    FMNL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FMNL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.100217

    UniProtKB/Swiss-Prot: FMNL_HUMAN, O95466
    Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMNL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FMNL1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fmnl15 formin-like 1   --   11 (66.71 cM) 103171107 
    chicken
    (Gallus gallus)
    Aves FMNL16
    Uncharacterized protein
    73(a)
    1 ↔ 1
    27(1387803-1407128)
    lizard
    (Anolis carolinensis)
    Reptilia FMNL16
    formin-like 1
    70(a)
    1 ↔ 1
    6(65313918-65408923)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.57622 Transcribed sequence with weak similarity to protein more 77.53(n)    BQ526413.1 
    zebrafish
    (Danio rerio)
    Actinopterygii FMNL1 (2 of 2)6
    fmnl1a6
    formin-like 1a
    57(a)
    55(a)
    1 ↔ many
    1 ↔ many
    24(38080714-38110063) ENSDARG00000075519
    3(37192468-37230082) ENSDARG00000055713
    fruit fly
    (Drosophila melanogaster)
    Insecta CG321386
    --
    38(a)
    1 → many
    3L(14046796-14064683)
    worm
    (Caenorhabditis elegans)
    Secernentea frl-16
    Protein FRL-1 (frl-1) mRNA, complete cds
    32(a)
    1 → many
    III(2134475-2151554) WBGene00021698


    ENSEMBL Gene Tree for FMNL1 (if available)
    TreeFam Gene Tree for FMNL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FMNL1 gene
    DAAM12  DIAPH12  FMNL32  FHDC12  DAAM22  INF22  FMNL22  GRID2IP2  
    FMN12  DIAPH22  FMN22  DIAPH32  
    4 SIMAP similar genes for FMNL1 using alignment to 6 protein entries:     FMNL_HUMAN (see all proteins):
    FLJ00304    DKFZp762B245    FMNL2    FMNL3

    Find genes that share paralogs with FMNL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FMNL1 (see all 574)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1851522321,2
    --39062263(+) GGAACA/CCCAGT 1 -- int10--------
    rs72213881,2
    C,F,H--39062290(+) CCCGGG/CGTGGC 1 -- int19Minor allele frequency- C:0.03NS EA NA WA 674
    rs1168406481,2
    C,F--39062376(+) CATTCC/TCCACC 1 -- int11Minor allele frequency- T:0.04WA 118
    rs1512100491,2
    C--39062485(+) GTATCA/GCAGAG 1 -- int10--------
    rs754683471,2
    C,F--39062621(+) CCAGTC/ATCAAT 1 -- int12Minor allele frequency- A:0.14NA EA 240
    rs780889341,2
    F--39062684(+) CTCTTC/GCTTCC 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1403920581,2
    --39062897(+) AAATGA/GGGGTG 1 -- int10--------
    rs1503871731,2
    --39062899(+) ATGGGG/TGTGGA 1 -- int10--------
    rs80653871,2
    C,F,H--39063010(+) ACCAGC/TCAGCG 1 -- int16Minor allele frequency- T:0.02NS EA CSA WA 538
    rs1380983281,2
    C--39063014(+) GCCAGC/TGGGGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for FMNL1 (43298811 - 43324687 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FMNL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1004857CNV Deletion20482838
    nsv908302CNV Loss21882294
    nsv527788CNV Loss19592680
    nsv908303CNV Loss21882294
    nsv908300CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FMNL1
    DNA2.0 Custom Variant and Variant Library Synthesis for FMNL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604656    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for FMNL1:
    Chondrosarcoma

    Find genes that share disorders with FMNL1           About GenesLikeMe

    3 Novoseek inferred disease relationships for FMNL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondrosarcoma 61.2 1 12684686 (1)
    glioblastoma 49.4 1 12684686 (1)
    melanoma 26.5 1 12684686 (1)


    Export disorders for FMNL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FMNL1 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with FMNL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17. (PubMed id 9799091)1, 2, 3 Aronsson F.C.... Brookes A.J. (Hum. Genet. 1998)
    2. Formin-like 1 (FMNL1) is regulated by N-terminal myristoylation and induces polarized membrane blebbing. (PubMed id 19815554)1, 2, 9 Han Y.... Krackhardt A.M. (J. Biol. Chem. 2009)
    3. Bi-modal regulation of a formin by srGAP2. (PubMed id 21148482)1, 2 Mason F.M.... Soderling S.H. (J. Biol. Chem. 2011)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico. (PubMed id 12684686)1, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2003)
    7. Human leukocyte formin: a novel protein expressed in lymphoid malignancies and associated with Akt. (PubMed id 14592423)1, 9 Favaro P.M....Saad S.T. (Biochem. Biophys. Res. Commun. 2003)
    8. Identification and characterization of human DAAM2 gene in silico. (PubMed id 12632087)1, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2003)
    9. FMNL1 promotes proliferation and migration of leukemia cells. (PubMed id 23801653)1 Favaro P....Saad S.T. (J. Leukoc. Biol. 2013)
    10. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 752 HGNC: 1212 AceView: FMNL1 Ensembl:ENSG00000184922 euGenes: HUgn752
    ECgene: FMNL1 H-InvDB: FMNL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FMNL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FMNL1 gene:
    Search GeneIP for patents involving FMNL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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