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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FMNL1 Gene

protein-coding   GIFtS: 54
GCID: GC17P043299

Formin-Like 1

(Previous name: formin-like)
(Previous symbols: C17orf1B, FMNL)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Formin-Like 11 2     CLL-Associated Antigen KW-132 3
C17orf1B1 2 3 5     formin-like1
FMNL1 2 3 5     FHOD42
Leukocyte Formin2 3     KW-132
C17orf12 3     Formin-Like Protein 12

External Ids:    HGNC: 12121   Entrez Gene: 7522   Ensembl: ENSG000001849227   OMIM: 6046565   UniProtKB: O954663   

Export aliases for FMNL1 gene to outside databases

Previous GC identifers: GC17P043774 GC17P040656 GC17P039060


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FMNL1 Gene:
This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis,
cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has
not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for FMNL1 Gene: 
FMNL1 (formin-like 1) is a protein-coding gene. Diseases associated with FMNL1 include frontotemporal dementia, and chondrosarcoma. GO annotations related to this gene include Rac GTPase binding and molecular_function. An important paralog of this gene is DAAM1.

UniProtKB/Swiss-Prot: FMNL_HUMAN, O95466
Function: May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a
role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament
dynamics and cell shape

Gene Wiki entry for FMNL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FMNL1 gene promoter:
         c-Fos   ISGF-3   AP-1   MAZR   JunB   Fra-1   FosB   JunD   HSF2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFMNL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FMNL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FMNL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

FMNL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FMNL1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P043299:  view genomic region     (about GC identifiers)

Start:
43,298,811 bp from pter      End:
43,324,687 bp from pter
Size:
25,877 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FMNL_HUMAN, O95466 (See protein sequence)
Recommended Name: Formin-like protein 1  
Size: 1100 amino acids; 121854 Da
Subunit: Interacts with RAC1, PFN1 and PFN2 (By similarity). Interacts (activated by RAC1) with SRGAP2 (via SH3
domain); regulates the actin filament severing activity of FMNL1
Subcellular location: Cytoplasm (By similarity). Cell membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome (By
similarity). Note=Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane
upon activation by RAC1 (By similarity)
Subcellular location: Isoform 3: Cytoplasm, cell cortex. Cell projection, bleb. Note=Colocalized with F-actin in
bleb protrusions
Sequence caution: Sequence=AAH21906.1; Type=Erroneous initiation; Sequence=CAA07870.1; Type=Erroneous initiation;
Secondary accessions: D2DGW2 Q6DKG5 Q6IBP3 Q86UH1 Q8N671 Q8TDH1 Q96H10
Alternative splicing: 3 isoforms:  O95466-1   O95466-2   O95466-3   (Due to intron retention. Constitutively activated form, probably due to alterations in the DAD domain)

Explore the universe of human proteins at neXtProt for FMNL1: NX_O95466

Explore proteomics data for FMNL1 at MOPED 

Post-translational modifications:

  • UniProtKB: Myristoylation mediates membrane localization and blebbing
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95466

  • FMNL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FMNL1 Protein Expression
    REFSEQ proteins: NP_005883.2  
    ENSEMBL proteins: 
     ENSP00000329219   ENSP00000465474   ENSP00000465137   ENSP00000466711   ENSP00000468301  
     ENSP00000327442  

    Human Recombinant Protein Products for FMNL1: 
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    Cloud-Clone Corp. Proteins for FMNL1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol ISS--
    GO:0005886plasma membrane ISS--
    GO:0005938cell cortex IEA--
    GO:0032059bleb IEA--
    GO:0045335phagocytic vesicle ISS--

    FMNL1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR010473 Drf_GTPase-bd
     IPR010472 Drf_FH3
     IPR015425 FH2_actin-bd
     IPR014767 Diaphanous_autoregulatory
     IPR003104 Actin-bd_FH2/DRF_autoreg

    Graphical View of Domain Structure for InterPro Entry O95466

    ProtoNet protein and cluster: O95466

    2 Blocks protein domains:
    IPB003104 Actin-binding FH2
    IPB010472 Diaphanous FH3


    UniProtKB/Swiss-Prot: FMNL_HUMAN, O95466
    Domain: The DAD domain regulates activation via by an autoinhibitory interaction with the N-terminus. This
    autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2
    domain to then nucleate and elongate nonbranched actin filaments (By similarity)
    Similarity: Belongs to the formin homology family
    Similarity: Contains 1 DAD (diaphanous autoregulatory) domain
    Similarity: Contains 1 FH2 (formin homology 2) domain
    Similarity: Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain


    FMNL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FMNL_HUMAN, O95466
    Function: May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a
    role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament
    dynamics and cell shape

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003779actin binding ----
    GO:0005488binding ----
    GO:0005515protein binding IPI--
    GO:0005522profilin binding IEA--
         
    FMNL1 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FMNL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/12 Interacting proteins for FMNL1 (O954661, 2, 3 ENSP000003292194) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRCC6P129562, 3, ENSP000003522574MINT-63311 I2D: score=5 STRING: ENSP00000352257
    GAS7O608612, 3, ENSP000003226084MINT-72916 I2D: score=3 STRING: ENSP00000322608
    PRPF40AO754002, 3MINT-61850 I2D: score=5 
    PFN1P077373, ENSP000002256554I2D: score=3 STRING: ENSP00000225655
    PFN2P350803, ENSP000002399404I2D: score=1 STRING: ENSP00000239940
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006929substrate-dependent cell migration IEA--
    GO:0008360regulation of cell shape IMP--
    GO:0009987cellular process ----
    GO:0016043cellular component organization ----
    GO:0030036actin cytoskeleton organization ----

    FMNL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FMNL1 (FMNL)

    Search CenterWatch for drugs/clinical trials and news about FMNL1 / FMNL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FMNL1 gene: 
    NM_005892.3  

    Unigene Cluster for FMNL1:

    Formin-like 1
    Hs.100217  [show with all ESTs]
    Unigene Representative Sequence: AK131091
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592415 ENST00000331495(uc002iin.3 uc021tyj.1) ENST00000585852
    ENST00000592006 ENST00000592527 ENST00000587856 ENST00000591434 ENST00000587489
    ENST00000586643 ENST00000589911 ENST00000586092 ENST00000328118(uc002iio.3 uc002iip.1 uc002iiq.3 uc010dag.3)


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    hsa-miR-105* hsa-miR-3163 hsa-miR-218-1* hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidFMNL1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF432213.1 AJ008112.1 AJ008113.1 AJ008114.1 AJ008115.1 AJ008116.1 AJ008117.1 AJ008118.1 
    AJ008119.1 AJ008120.1 AJ008121.1 AJ008122.1 AJ008123.1 AJ008124.1 AJ008126.1 AJ008127.1 
    AJ008128.1 AJ008129.1 AJ008130.1 AJ008131.1 AJ008132.1 AJ008133.1 AK131091.1 AY278319.1 
    BC001710.1 BC009000.2 BC021906.1 BC042925.1 BC064572.1 BC073988.1 CR456759.1 FJ534522.1 

    23 DOTS entries:

    DT.305475  DT.95294122  DT.97844663  DT.96086455  DT.99951976  DT.100718200  DT.100839865  DT.120945533 
    DT.75139817  DT.120945560  DT.99953217  DT.75188035  DT.95294135  DT.120945631  DT.91749549  DT.97815418 
    DT.100820826  DT.97801671  DT.91785298  DT.95070943  DT.99965614  DT.120945688  DT.97813760 

    24/213 AceView cDNA sequences (see all 213):

    BU145332 AJ008117 AJ008113 BU529060 AJ008130 BQ109528 BC001710 BG235961 
    BC042925 CR616114 BI868449 AJ008119 AI336008 BQ054225 AF432213 CA427251 
    BG744467 BI907951 BI028593 BQ918146 AY278319 CA308198 CD368295 NM_005892 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for FMNL1 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^
    SP1:                                                                                                                                                            
    SP2:                                                        -           -                                         -                                             
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                              -                                             

    ExUns: 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b · 23c ^ 24 ^ 25 ^ 26a · 26b ^ 27
    SP1:                                                                                -         
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for FMNL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FMNL1 expression in normal human tissues (normalized intensities)      FMNL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCTTATTT
    FMNL1 Expression
    About this image


    FMNL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             bone marrow   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; non-germinal center cells   
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             lymph node ; non-germinal center cells   
     
     Spleen (Hematopoietic System)    fully expand to see all 2 entries
             spleen ; cells in white pulp   
     
     Lung (Respiratory System)
             lung ; macrophages   

    See FMNL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FMNL1

    SOURCE GeneReport for Unigene cluster: Hs.100217

    UniProtKB/Swiss-Prot: FMNL_HUMAN, O95466
    Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMNL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FMNL1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fmnl11 , 5 formin-like 11, 5 85.78(n)1
    89.87(a)1
      11 (66.71 cM)5
    577781  NM_001077698.11  NP_001071166.11 
     1031711075 
    chicken
    (Gallus gallus)
    Aves FMNL11 formin-like 1 77.79(n)
    77.38(a)
      419965  XM_001234504.2  XP_001234505.2 
    lizard
    (Anolis carolinensis)
    Reptilia FMNL16
    Uncharacterized protein
    71(a)
    1 ↔ 1
    6(65313918-65408923)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.57622 Transcribed sequence with weak similarity to protein more 77.53(n)    BQ526413.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5570621 uncharacterized LOC557062 64.34(n)
    63.74(a)
      557062  XM_680041.3  XP_685133.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG321386
    --
    36(a)
    1 → many
    3L(14046796-14064683)
    worm
    (Caenorhabditis elegans)
    Secernentea frl-16
    Protein FRL-1
    31(a)
    1 → many
    III(2134475-2151554)


    ENSEMBL Gene Tree for FMNL1 (if available)
    TreeFam Gene Tree for FMNL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FMNL1 gene
    DAAM12  DIAPH12  FMNL32  FHDC12  DAAM22  INF22  FMNL22  GRID2IP2  
    FMN12  DIAPH22  FMN22  DIAPH32  
    4 SIMAP similar genes for FMNL1 using alignment to 6 protein entries:     FMNL_HUMAN (see all proteins):
    FLJ00304    DKFZp762B245    FMNL2    FMNL3

    FMNL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/574 SNPs in FMNL1 are shown (see all 574)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1851522321,2
    --39062263(+) GGAACA/CCCAGT 1 -- int10--------
    rs72213881,2
    C,F,H--39062290(+) CCCGGG/CGTGGC 1 -- int19Minor allele frequency- C:0.03NS EA NA WA 674
    rs1168406481,2
    C,F--39062376(+) CATTCC/TCCACC 1 -- int11Minor allele frequency- T:0.04WA 118
    rs1512100491,2
    C--39062485(+) GTATCA/GCAGAG 1 -- int10--------
    rs754683471,2
    C,F--39062621(+) CCAGTC/ATCAAT 1 -- int12Minor allele frequency- A:0.14NA EA 240
    rs780889341,2
    F--39062684(+) CTCTTC/GCTTCC 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1403920581,2
    --39062897(+) AAATGA/GGGGTG 1 -- int10--------
    rs1503871731,2
    --39062899(+) ATGGGG/TGTGGA 1 -- int10--------
    rs80653871,2
    C,F,H--39063010(+) ACCAGC/TCAGCG 1 -- int16Minor allele frequency- T:0.02NS EA CSA WA 538
    rs1380983281,2
    C--39063014(+) GCCAGC/TGGGGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for FMNL1 (43298811 - 43324687 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FMNL1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1004857CNV Deletion20482838
    nsv908302CNV Loss21882294
    nsv527788CNV Loss19592680
    nsv908303CNV Loss21882294
    nsv908300CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604656    OMIM disorders: --

    5 diseases for FMNL1:    About MalaCards
    frontotemporal dementia    chondrosarcoma    dementia    non-hodgkin lymphoma
    hodgkin's lymphoma

    1 disease from the University of Copenhagen DISEASES database for FMNL1:
    Chondrosarcoma

    FMNL1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for FMNL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondrosarcoma 61.2 1 12684686 (1)
    glioblastoma 49.4 1 12684686 (1)
    melanoma 26.5 1 12684686 (1)


    Export disorders for FMNL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FMNL1 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with FMNL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17. (PubMed id 9799091)1, 2, 3 Aronsson F.C.... Brookes A.J. (1998)
    2. Formin-like 1 (FMNL1) is regulated by N-terminal myristoylation and induces polarized membrane blebbing. (PubMed id 19815554)1, 2, 9 Han Y.... Krackhardt A.M. (2009)
    3. Bi-modal regulation of a formin by srGAP2. (PubMed id 21148482)1, 2 Mason F.M....Soderling S.H. (2011)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico. (PubMed id 12684686)1, 9 Katoh M. and Katoh M. (2003)
    7. Human leukocyte formin: a novel protein expressed in lymphoid malignancies and associated with Akt. (PubMed id 14592423)1, 9 Favaro P.M....Saad S.T. (2003)
    8. Identification and characterization of human DAAM2 gene in silico. (PubMed id 12632087)1, 9 Katoh M. and Katoh M. (2003)
    9. Proteomic investigation of the interactome of FMNL1 in hematopoietic cells unveils a role in calcium-dependent membrane plasticity. (PubMed id 23182705)1 Han Y....Krackhardt A.M. (2013)
    10. The formins FMNL1 and mDia1 regulate coiling phagocyto sis of Borrelia burgdorferi by primary human macrophages. (PubMed id 23460512)1 Naj X....Linder S. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 752 HGNC: 1212 AceView: FMNL1 Ensembl:ENSG00000184922 euGenes: HUgn752
    ECgene: FMNL1 H-InvDB: FMNL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FMNL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FMNL1 gene:
    Search GeneIP for patents involving FMNL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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